MCID: TRN013
MIFTS: 16

Transient Neonatal Thrombocytopenia

Categories: Blood diseases, Fetal diseases

Aliases & Classifications for Transient Neonatal Thrombocytopenia

MalaCards integrated aliases for Transient Neonatal Thrombocytopenia:

Name: Transient Neonatal Thrombocytopenia 12 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9771
ICD9CM 34 776.1
SNOMED-CT 67 23205009
ICD10 32 P61.0
UMLS 70 C0158991

Summaries for Transient Neonatal Thrombocytopenia

MalaCards based summary : Transient Neonatal Thrombocytopenia is related to fetal and neonatal alloimmune thrombocytopenia and chromosome 3q29 duplication syndrome. An important gene associated with Transient Neonatal Thrombocytopenia is COX20 (Cytochrome C Oxidase Assembly Factor COX20), and among its related pathways/superpathways is TP53 Regulates Metabolic Genes. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Transient Neonatal Thrombocytopenia

Diseases related to Transient Neonatal Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 fetal and neonatal alloimmune thrombocytopenia 10.3
2 chromosome 3q29 duplication syndrome 9.7 ZBTB18 COX20
3 transient neonatal neutropenia 8.7 ZBTB18 TRIM21 HNRNPU COX20 AKT3

Symptoms & Phenotypes for Transient Neonatal Thrombocytopenia

GenomeRNAi Phenotypes related to Transient Neonatal Thrombocytopenia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.28 ZBTB18
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.28 AKT3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.28 AKT3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.28 ZBTB18
5 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.28 ZBTB18
6 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.28 AKT3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.28 AKT3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.28 ZBTB18
9 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.28 AKT3
10 Decreased interferon-beta reporter expression GR00307-A 8.96 HNRNPU TRIM21

MGI Mouse Phenotypes related to Transient Neonatal Thrombocytopenia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.02 AKT3 COX20 HNRNPU TRIM21 ZBTB18

Drugs & Therapeutics for Transient Neonatal Thrombocytopenia

Search Clinical Trials , NIH Clinical Center for Transient Neonatal Thrombocytopenia

Genetic Tests for Transient Neonatal Thrombocytopenia

Anatomical Context for Transient Neonatal Thrombocytopenia

Publications for Transient Neonatal Thrombocytopenia

Articles related to Transient Neonatal Thrombocytopenia:

# Title Authors PMID Year
1
A child with complementary mosaic trisomy 8 and mosaic trisomy 21; clinical description of Warkany-Down syndrome and mechanism of origin. 61
32240827 2020
2
Spontaneous intrauterine umbilical artery thrombosis leading to severe fetal growth restriction. 61
18289672 2008
3
von Voss-Cherstvoy syndrome with transient thrombocytopenia and normal psychomotor development. 61
15054846 2004
4
Thrombocytopenia in the neonatal lupus syndrome. 61
3258497 1988
5
Studies by enzyme-linked immunosorbent assay (ELISA) of antiplatelet antibody and transient neonatal thrombocytopenic purpura. 61
6683939 1983
6
Elution of granulocyte and platelet antibodies. 61
6182693 1982
7
[Caesarean section with splenectomy in a patient with idiopathic thrombocytopenic purpura (author's transl)]. 61
7191242 1980

Variations for Transient Neonatal Thrombocytopenia

Expression for Transient Neonatal Thrombocytopenia

Search GEO for disease gene expression data for Transient Neonatal Thrombocytopenia.

Pathways for Transient Neonatal Thrombocytopenia

Pathways related to Transient Neonatal Thrombocytopenia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 COX20 AKT3

GO Terms for Transient Neonatal Thrombocytopenia

Cellular components related to Transient Neonatal Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ribonucleoprotein complex GO:1990904 8.62 TRIM21 HNRNPU

Sources for Transient Neonatal Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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