TPHA
MCID: TRN053
MIFTS: 25

Transient Pseudohypoaldosteronism (TPHA)

Categories: Blood diseases, Cardiovascular diseases, Endocrine diseases, Genetic diseases, Metabolic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Transient Pseudohypoaldosteronism

MalaCards integrated aliases for Transient Pseudohypoaldosteronism:

Name: Transient Pseudohypoaldosteronism 58
Secondary Pseudohypoaldosteronism 58
Tpha 58

Classifications:

Orphanet: 58  
Rare renal diseases


External Ids:

ICD10 via Orphanet 33 N15.8
Orphanet 58 ORPHA93164

Summaries for Transient Pseudohypoaldosteronism

MalaCards based summary : Transient Pseudohypoaldosteronism, also known as secondary pseudohypoaldosteronism, is related to syphilis and pseudohypoaldosteronism. The drugs Azithromycin and carbamide peroxide have been mentioned in the context of this disorder. Affiliated tissues include testes, whole blood and liver.

Related Diseases for Transient Pseudohypoaldosteronism

Diseases in the Pseudohypoaldosteronism family:

Pseudohypoaldosteronism, Type Iia Pseudohypoaldosteronism, Type I, Autosomal Dominant
Pseudohypoaldosteronism, Type I, Autosomal Recessive Pseudohypoaldosteronism, Type Iib
Pseudohypoaldosteronism, Type Iic Pseudohypoaldosteronism, Type Iid
Pseudohypoaldosteronism, Type Iie Transient Pseudohypoaldosteronism

Diseases related to Transient Pseudohypoaldosteronism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 syphilis 11.0
2 pseudohypoaldosteronism 10.7
3 acute cystitis 10.5
4 primary syphilis 10.5
5 lipoid congenital adrenal hyperplasia 10.5
6 urinary tract obstruction 10.4
7 secondary syphilis 10.3
8 hydronephrosis 10.3
9 pyelonephritis 10.3
10 asymptomatic neurosyphilis 10.2
11 yaws 10.2
12 neurosyphilis 10.2
13 vesicoureteral reflux 1 10.2
14 metabolic acidosis 10.2
15 posterior urethral valves 10.2
16 acute pyelonephritis 10.1
17 leprosy 3 10.1
18 late congenital syphilis 10.1
19 lepromatous leprosy 10.1
20 tertiary syphilis 10.1
21 latent syphilis 10.1
22 congenital syphilis 10.1
23 hansen's disease 10.1
24 congenital anomalies of kidney and urinary tract 2 10.0
25 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.0
26 pyloric stenosis 10.0
27 renal tubular acidosis 10.0
28 pneumothorax 10.0
29 acute kidney failure 10.0
30 kidney disease 10.0
31 thrombophilia due to thrombin defect 10.0
32 cardiac arrest 10.0
33 thrombosis 10.0
34 cholelithiasis 10.0
35 thrombocytopenia 10.0
36 phimosis 10.0
37 hypotonia 10.0

Graphical network of the top 20 diseases related to Transient Pseudohypoaldosteronism:



Diseases related to Transient Pseudohypoaldosteronism

Symptoms & Phenotypes for Transient Pseudohypoaldosteronism

Drugs & Therapeutics for Transient Pseudohypoaldosteronism

Drugs for Transient Pseudohypoaldosteronism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 3 83905-01-5 447043 55185
2
carbamide peroxide Approved Phase 3 124-43-6
3
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
4
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
5 Antibiotics, Antitubercular Phase 3
6 Anti-Bacterial Agents Phase 3
7 Anti-Infective Agents Phase 3
8 Penicillin G Procaine Phase 3
9 Penicillin G Benzathine Phase 3
10 penicillins Phase 3
11 Dermatologic Agents Phase 3
12
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
13
Lenograstim Approved, Investigational Phase 2 135968-09-1
14 Adjuvants, Immunologic Phase 2
15 Immunologic Factors Phase 2
16 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Single-dose Azithromycin Versus Penicillin G Benzathine for the Treatment of Yaws in Children Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
2 Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea Completed NCT01955252 Phase 3 Azithromycin
3 A Open-label, No-treatment-controlled, Parallel, Pilot Phase Ⅱ Study to Evaluate the Efficacy and Safety/Tolerability Profiles of G-CSF in Subjects With Mild to Moderate Alzheimer's Disease Completed NCT03656042 Phase 2 Filgrastim (75mcg/0.3ml)
4 Xijing HOSPITAL, Fourth Military Medical University, China Completed NCT00921648
5 Regional Multicenter Study to Evaluate Tolerability and Efficacy of TAF/FTC/RPV Combination (ODEFSEY ®) in Prevention of Sexual or Blood Exposure to HIV Completed NCT03451032
6 Evaluation of a Rapid Dual Point-of-care Assay for Targeting Antibiotic Treatment for Yaws Eradication: a Prospective Descriptive Study Completed NCT01841203
7 2000 HIV Human Functional Genomics Partnership Program Not yet recruiting NCT03994835
8 Qualitative Evaluation of the DPP Syphilis Screen and Confirm Rapid Test to Detect the Presence of Antibodies Against Non-Treponemal and Treponema Pallidum Antigens in Fingerstick Whole Blood, Venous Whole Blood, Serum and Plasma Specimens. Withdrawn NCT01543295

Search NIH Clinical Center for Transient Pseudohypoaldosteronism

Genetic Tests for Transient Pseudohypoaldosteronism

Anatomical Context for Transient Pseudohypoaldosteronism

MalaCards organs/tissues related to Transient Pseudohypoaldosteronism:

40
Testes, Whole Blood, Liver, T Cells, Bone, Eye, Skin

Publications for Transient Pseudohypoaldosteronism

Articles related to Transient Pseudohypoaldosteronism:

(show top 50) (show all 654)
# Title Authors PMID Year
1
Time preference of headache attack and chronotype in migraine and tension-type headache. 61
31456434 2019
2
Neurosyphilis cerebrospinal fluid findings in patients with ocular syphilis. 61
31647700 2019
3
Syphilitic meningomyelitis misdiagnosed as spinal cord tumor: Case and review. 61
31603731 2019
4
Miliary Retinal Lesions in Ocular Syphilis: Imaging Characteristics and Outcomes. 61
31580177 2019
5
First report of hare treponematosis seroprevalence of European brown hares (Lepus europaeus) in the Czech Republic: seroprevalence negatively correlates with altitude of sampling areas. 61
31627750 2019
6
Performance of a Dual Human Immunodeficiency Virus/Syphilis Rapid Test Compared With Conventional Serological Testing for Syphilis and Human Immunodeficiency Virus in a Laboratory Setting: Results From the Zimbabwe STI Etiology Study. 61
31181033 2019
7
Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient. 61
31406542 2019
8
Clinical features of syphilitic myelitis with longitudinally extensive myelopathy on spinal magnetic resonance imaging. 61
31236392 2019
9
Transient pseudohypoaldosteronism: a potentially severe condition affecting infants with urinary tract malformation. 61
30962012 2019
10
[SOME PECULIARITIES OF SYPHILIS MORPHOLOGY AND PATHOLOGY (REVIEW)]. 61
31101787 2019
11
Limited efficacy of nontreponemal test combined with treponemal test in the initial syphilis screening algorithm. 61
30570479 2019
12
Performance evaluation of nine different syphilis serological tests in comparison with the FTA-abs test. 61
30138611 2019
13
Genital Herpes Zoster as Possible Indicator of HIV Infection. 61
30665486 2018
14
Evaluation of Treponema pallidum Hemagglutination Assay among Varying Titers of the Venereal Disease Research Laboratory Test. 61
30504976 2018
15
An infant presenting with failure to thrive and hyperkalaemia owing to transient pseudohypoaldosteronism: case report. 61
28557682 2018
16
The prevalence of transfusion-transmitted infections and nucleic acid testing among blood donors in Majmaah, Saudi Arabia. 61
29703711 2018
17
Features of syphilis seropositive pregnant women raising alarms in Hungary, 2013-2016. 61
30053759 2018
18
LATE DIAGNOSIS OF CONGENITAL SYPHILIS: A RECURRING REALITY IN WOMEN AND CHILDREN HEALTH CARE IN BRAZIL. 61
30066818 2018
19
[Transient Pseudohypoaldosteronism - an Important Differential Diagnosis to Congenital Adrenal Hyperplasia]. 61
29564839 2018
20
Unusual Manifestations of Secondary Syphilis: Case Presentations. 61
29989879 2018
21
Serological Diagnosis of Syphilis: Preliminary Study Searching for an Algorhitm in Turkey. 61
29989871 2018
22
[Multiple Spinal Intradural and Extradural Syphilis Granuloma Mimicking Lumbar Dumbbell Type Neurinoma:A Case Report]. 61
29794319 2018
23
Stroke and syphilis: A retrospective study of 53 patients. 61
29631855 2018
24
Trends and Predictors of Syphilis Prevalence in the General Population: Global Pooled Analyses of 1103 Prevalence Measures Including 136 Million Syphilis Tests. 61
29136161 2018
25
High seroprevalence of syphilis infection among pregnant women in Yiregalem hospital southern Ethiopia. 61
29510664 2018
26
Transient Pseudohypoaldosteronism Caused by Intestinal Abnormalities. 61
29237184 2018
27
Correlation between Venereal Diseases Research Laboratory titers and CD4 T-lymphocyte count determined by flow cytometry in HIV-infected adults: A 5-year study. 61
30187020 2018
28
Clinic-based evaluation study of the diagnostic accuracy of a dual rapid test for the screening of HIV and syphilis in pregnant women in Nigeria. 61
29990336 2018
29
Hidden dangers-prevalence of blood borne pathogens, hepatitis B, C, HIV and syphilis, among blood donors in Sierra Leone in 2016: opportunities for improvement: a retrospective, cross-sectional study. 61
30167071 2018
30
A retrospective study of the prevalence and outcomes of syphilis in pregnancy in a 5-year period. 61
28980302 2018
31
Comparison of RPR and ELISA with TPHA for the Diagnosis of Syphilis: Implication for Updating Syphilis Point-of-Care Tests in Ethiopia. 61
30069486 2018
32
Rapid Response to Syphilis Outbreak among Female Sex Workers. 61
29184321 2017
33
The big imitator strikes again: a case report of neurosyphilis in a patient with newly diagnosed HIV. 61
28220718 2017
34
Syphilis testing practices in the Americas. 61
28653418 2017
35
Congenital Jejunal Membrane Causing Transient Pseudohypoaldosteronism and Hypoprothrombinemia in a 7-Week-Old Infant. 61
28806843 2017
36
Tertiary syphilis in the lumbar spine: a case report. 61
28738852 2017
37
Cerebrospinal Fluid Treponema pallidum Particle Agglutination Assay for Neurosyphilis Diagnosis. 61
28381602 2017
38
Non-malarial infectious diseases of antenatal care in pregnant women in Franceville, Gabon. 61
28606185 2017
39
Transient pseudohypoaldosteronism in infancy secondary to urinary tract infection. 61
28233358 2017
40
Gastric syphilis. 61
28507905 2017
41
Prevalence and risk factors associated with sexually transmitted infections (STIs) among women of reproductive age in Swaziland. 61
28559923 2017
42
Syphilis and HIV infections among pregnant women attending antenatal clinics in Republic of Congo. 61
29138654 2017
43
[Skin and mucosal erosions revealing secondary syphilis with otologic and eye disorders]. 61
27646571 2016
44
[The role of reflectance confocal microscopy in the diagnosis of secondary syphilis of the vulva and anus: A first case report]. 61
27567281 2016
45
Utility of Laboratory Diagnosis for Confirmation of the Syndromic Case Management in Married Indian Women with Vaginal Discharge. 61
27833516 2016
46
Clinical Evaluation of 2 Point-of-Care Lateral Flow Tests for the Diagnosis of Syphilis. 61
27631356 2016
47
Secondary or Transient Pseudohypoaldosteronism Associated With Urinary Tract Anomaly and Urinary Infection: A Case Report. 61
27516976 2016
48
Sexually transmitted infections and HIV in self reporting men who have sex with men: A two-year study from India. 61
26776704 2016
49
Congenital primary adrenal insufficiency and selective aldosterone defects presenting as salt-wasting in infancy: a single center 10-year experience. 61
27485500 2016
50
Reducing risks of Transfusion-transmitted infections in a resource-limited hospital-based blood bank: the case of the Yaoundé University Teaching Hospital, Cameroon. 61
28484511 2016

Variations for Transient Pseudohypoaldosteronism

Expression for Transient Pseudohypoaldosteronism

Search GEO for disease gene expression data for Transient Pseudohypoaldosteronism.

Pathways for Transient Pseudohypoaldosteronism

GO Terms for Transient Pseudohypoaldosteronism

Sources for Transient Pseudohypoaldosteronism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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