MCID: TRN011
MIFTS: 27

Transient Refractive Change

Categories: Neuronal diseases

Aliases & Classifications for Transient Refractive Change

MalaCards integrated aliases for Transient Refractive Change:

Name: Transient Refractive Change 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11850
ICD9CM 34 367.81
SNOMED-CT 67 81519008
UMLS 70 C0155000

Summaries for Transient Refractive Change

MalaCards based summary : Transient Refractive Change is related to lateral displacement of eye and aniseikonia. An important gene associated with Transient Refractive Change is ADGRL4 (Adhesion G Protein-Coupled Receptor L4), and among its related pathways/superpathways are Oxytocin signaling pathway and cGMP-PKG signaling pathway. Affiliated tissues include pituitary, kidney and eye, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Transient Refractive Change

Diseases related to Transient Refractive Change via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 lateral displacement of eye 10.3 IRX6 IRX3
2 aniseikonia 10.3 IRX6 IRX3
3 cycloplegia 10.3 IRX6 IRX3
4 functional colonic disease 10.3 SST KCNMA1
5 colonic pseudo-obstruction 10.3 SST KCNMA1
6 eye accommodation disease 10.3 IRX6 IRX3
7 acidophil adenoma 10.2 SST INS
8 postgastrectomy syndrome 10.2 SST INS
9 duodenal somatostatinoma 10.2 SST INS
10 pituitary infarct 10.2 SST INS
11 pituitary apoplexy 10.2 SST INS
12 hyperpituitarism 10.2 SST INS
13 esophageal varix 10.2 SST INS
14 pulmonary arterial hypertension associated with connective tissue disease 10.2 EDNRB EDNRA
15 bullous impetigo 10.1 EDNRB EDNRA
16 impetigo 10.1 EDNRB EDNRA
17 retinal microaneurysm 10.1 INS AKR1B1
18 radiation proctitis 10.1 EDNRB EDNRA
19 ocular hyperemia 10.1 MYLK EDN1
20 chronic mountain sickness 10.1 SST EDN1
21 idiopathic edema 10.1 INS EDN1
22 severe nonproliferative diabetic retinopathy 10.1 INS AKR1B1
23 pancreatic endocrine carcinoma 10.1 SST INS
24 ritter's disease 10.1 EDNRB EDNRA
25 malignant renovascular hypertension 10.1 EDNRA EDN1
26 scarlet fever 10.1 EDNRB EDNRA
27 mandibulofacial dysostosis with alopecia 10.1 EDNRA EDN1
28 anhidrosis, isolated, with normal sweat glands 10.1 EDNRA EDN1
29 waardenburg syndrome, type 4b 10.0 EDNRB EDNRA
30 malignant secondary hypertension 10.0 EDNRA EDN1
31 nephrogenic systemic fibrosis 10.0 EDNRA EDN1
32 dumping syndrome 10.0 SST INS
33 pituitary tumors 10.0
34 diabetic neuropathy 10.0 SORD INS AKR1B1
35 sexual disorder 10.0 KCNMA1 INS EDN1
36 intestinal pseudo-obstruction 10.0 SST MYLK EDNRB
37 appendix lymphoma 10.0 TAC1 SST
38 algoneurodystrophy 10.0 TAC1 INS
39 hepatic vascular disease 10.0 SST INS EDN1
40 vein disease 10.0 SST INS EDN1
41 neurogenic arthropathy 10.0 TAC1 INS
42 paralytic ileus 9.9 TAC1 INS
43 persistent fetal circulation syndrome 9.9 INS EDNRA EDN1
44 diabetic autonomic neuropathy 9.9 INS AKR1B1
45 prurigo nodularis 9.9 TAC1 EDN1
46 acquired color blindness 9.9 EDNRB EDNRA EDN1
47 perinephritis 9.9 EDNRB EDNRA EDN1
48 raynaud disease 9.9 EDNRB EDNRA EDN1
49 patent foramen ovale 9.9 SST EDNRA EDN1
50 chronic pulmonary heart disease 9.9 EDNRB EDNRA EDN1

Graphical network of the top 20 diseases related to Transient Refractive Change:



Diseases related to Transient Refractive Change

Symptoms & Phenotypes for Transient Refractive Change

MGI Mouse Phenotypes related to Transient Refractive Change:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 EDN1 EDNRA EDNRB INS IRX3 KCNMA1
2 homeostasis/metabolism MP:0005376 10.11 AKR1B1 EDN1 EDNRA EDNRB INS IRX3
3 digestive/alimentary MP:0005381 9.95 EDN1 EDNRA EDNRB INS KCNMA1 MYLK
4 muscle MP:0005369 9.87 EDN1 EDNRA EDNRB INS KCNMA1 MYLK
5 normal MP:0002873 9.86 ADGRL4 EDN1 EDNRA INS MYLK SORD
6 renal/urinary system MP:0005367 9.76 AKR1B1 EDN1 EDNRA EDNRB INS KCNMA1
7 skeleton MP:0005390 9.56 AKR1B1 EDN1 EDNRA EDNRB INS IRX3
8 vision/eye MP:0005391 9.28 AKR1B1 EDNRA EDNRB INS IRX3 IRX6

Drugs & Therapeutics for Transient Refractive Change

Search Clinical Trials , NIH Clinical Center for Transient Refractive Change

Genetic Tests for Transient Refractive Change

Anatomical Context for Transient Refractive Change

MalaCards organs/tissues related to Transient Refractive Change:

40
Pituitary, Kidney, Eye, Heart, Liver, Appendix

Publications for Transient Refractive Change

Articles related to Transient Refractive Change:

# Title Authors PMID Year
1
A case with transient refractive change after removal of pituitary tumor. 61
24180221 2013
2
Diabetic myopia--is it lens-induced? An oculometric study comprising ultrasound measurements. 61
3310510 1987
3
Refractive change in diabetes mellitus around onset or when poorly controlled. A clinical study. 61
3554882 1987
4
Transient refractive change following healing of corneal abrasions. 61
5726541 1968

Variations for Transient Refractive Change

Expression for Transient Refractive Change

Search GEO for disease gene expression data for Transient Refractive Change.

Pathways for Transient Refractive Change

GO Terms for Transient Refractive Change

Biological processes related to Transient Refractive Change according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.86 TAC1 SST RHO INS EDNRB EDNRA
2 cell surface receptor signaling pathway GO:0007166 9.85 SST EDNRB EDN1 ADGRL4
3 cell-cell signaling GO:0007267 9.81 TAC1 SST INS EDN1
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.71 TAC1 EDNRB EDNRA EDN1
5 sensory perception of pain GO:0019233 9.65 TAC1 EDNRB EDN1
6 positive regulation of mitotic nuclear division GO:0045840 9.61 INS EDN1
7 neural crest cell development GO:0014032 9.61 EDNRA EDN1
8 response to osmotic stress GO:0006970 9.6 SORD KCNMA1
9 regulation of pH GO:0006885 9.59 EDNRB EDN1
10 response to pain GO:0048265 9.58 TAC1 EDNRB
11 enteric nervous system development GO:0048484 9.58 EDNRB EDNRA
12 smooth muscle contraction GO:0006939 9.57 MYLK EDNRA
13 positive regulation of urine volume GO:0035810 9.56 EDNRB EDN1
14 artery smooth muscle contraction GO:0014824 9.54 EDNRA EDN1
15 regulation of glucose transmembrane transport GO:0010827 9.52 EDNRA EDN1
16 vasoconstriction GO:0042310 9.5 EDNRB EDNRA EDN1
17 epithelial fluid transport GO:0042045 9.49 EDNRB EDN1
18 negative regulation of cellular protein metabolic process GO:0032269 9.46 EDNRB EDN1
19 vein smooth muscle contraction GO:0014826 9.43 EDNRB EDN1
20 fructose biosynthetic process GO:0046370 9.37 SORD AKR1B1
21 positive regulation of renal sodium excretion GO:0035815 9.33 TAC1 EDNRB EDN1
22 regulation of blood pressure GO:0008217 9.26 TAC1 EDNRB EDNRA EDN1
23 endothelin receptor signaling pathway GO:0086100 8.8 EDNRB EDNRA EDN1

Molecular functions related to Transient Refractive Change according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 SST INS EDN1
2 endothelin receptor activity GO:0004962 8.62 EDNRB EDNRA

Sources for Transient Refractive Change

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....