MCID: TRN018
MIFTS: 56

Transitional Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Transitional Cell Carcinoma

MalaCards integrated aliases for Transitional Cell Carcinoma:

Name: Transitional Cell Carcinoma 12 73 20 15 17
Carcinoma, Transitional Cell 44 70
Transitional Cell Neoplasm 12 70
Transitional Cell Carcinoma of Bladder 70
Carcinoma Transitional Cell 54
Urothelial Cell Carcinoma 12
Transitional Cell Tumor 12
Transitional Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2671
MeSH 44 D002295
NCIt 50 C2930 C6783
SNOMED-CT 67 118287003 27090000
UMLS 70 C0007138 C0279680 C0334265

Summaries for Transitional Cell Carcinoma

Disease Ontology : 12 A carcinoma that derives from transitional epithelial cells.

MalaCards based summary : Transitional Cell Carcinoma, also known as carcinoma, transitional cell, is related to sarcomatoid transitional cell carcinoma and urethra transitional cell carcinoma. An important gene associated with Transitional Cell Carcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Vitamin D and Vitamin D3 have been mentioned in the context of this disorder. Affiliated tissues include prostate, kidney and lymph node, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 Transitional cell carcinoma, also called urothelial carcinoma, is a type of cancer that typically occurs... more...

Related Diseases for Transitional Cell Carcinoma

Diseases related to Transitional Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 783)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid transitional cell carcinoma 33.3 TP53 CDH1
2 urethra transitional cell carcinoma 32.9 UPK3A TP53
3 bladder urothelial carcinoma 32.9 UPK3A TP53 PTEN KRT20 HRAS FGFR3
4 renal pelvis transitional cell carcinoma 32.6 UPK3A KRT7
5 fallopian tube carcinoma 32.5 TP53 PTEN ERBB2
6 papillary transitional carcinoma 32.3 UPK3A TP53 KRT7 KRT20 BRINP1
7 in situ carcinoma 32.1 TP53 PTEN HRAS ERBB2 EGFR CDKN2A
8 bladder papillary transitional cell neoplasm 32.0 UPK3A TP53 KRT20 FGFR3 BRINP1
9 prostate cancer 31.9 TP53 PTEN MKI67 HRAS FGFR3 ERBB3
10 squamous cell papilloma 31.8 TP53 HRAS CDKN2A
11 urinary tract papillary transitional cell benign neoplasm 31.8 UPK3A TP53 KRT20 FGFR3 BRINP1
12 hydronephrosis 31.5 UPK3A UPK2 UPK1B KRT7
13 bladder cancer 31.3 UPK3A UPK2 UPK1A TP53 PTEN MKI67
14 cystitis 31.3 UPK3A UPK1A TP53 KRT7 KRT20 CDH1
15 papilloma 31.2 TP53 PTEN KRT7 KRT20 FGFR3 ERBB2
16 renal cell carcinoma, nonpapillary 31.2 TP53 PTEN MKI67 KRT7 KRT20 HRAS
17 ureteral benign neoplasm 31.1 UPK3A KRT7
18 papillary carcinoma 31.1 KRT7 KRT20 ERBB2 CDH1 BRAF
19 inverted papilloma 31.1 TP53 MKI67 KRT7 KRT20 EGFR CDKN2A
20 ovarian brenner tumor 31.1 UPK3A KRT7 KRT20 CDKN2A
21 exanthem 31.1 HRAS ERBB2 EGFR
22 serous cystadenocarcinoma 31.1 TP53 PTEN HRAS ERBB2 BRAF
23 appendix adenocarcinoma 31.0 KRT7 KRT20 HRAS
24 human papillomavirus infectious disease 31.0 TP53 CDKN2A
25 vesicoureteral reflux 1 31.0 UPK3A UPK2 UPK1B UPK1A
26 mammary paget's disease 31.0 KRT7 KRT20 ERBB2 EGFR
27 small cell carcinoma 31.0 TP53 PTEN KRT7 KRT20 ERBB2 EGFR
28 lynch syndrome 31.0 TP53 PTEN HRAS FGFR3 EGFR CDKN2A
29 horseshoe kidney 30.9 KRT7 KRT20 EGFR
30 suppression of tumorigenicity 12 30.9 TP53 PTEN HRAS ERBB2 EGFR CDKN2A
31 peripheral nervous system disease 30.9 TP53 PTEN HRAS ERBB2 EGFR CDKN2A
32 neurogenic bladder 30.9 UPK3A UPK1A ERBB3
33 mucinous adenocarcinoma 30.9 TP53 KRT7 KRT20 ERBB2 EGFR CDKN2A
34 interstitial cystitis 30.9 UPK3A UPK1A CDH1
35 adenocarcinoma 30.8 TP53 PTEN KRT7 KRT20 HRAS FGFR3
36 polycystic kidney disease 30.7 TP53 ERBB2 EGFR CDH1 BRAF
37 urethral diverticulum 30.7 UPK3A KRT7
38 clear cell adenocarcinoma 30.7 TP53 KRT7 KRT20
39 myeloma, multiple 30.7 TP53 PTEN HRAS FGFR3 ERBB2 EGFR
40 kidney cancer 30.7 TP53 PTEN EGFR CDKN2A
41 melanoma 30.7 TP53 PTEN HRAS ERBB2 EGFR CDKN2A
42 muir-torre syndrome 30.7 TP53 KRT7 CDKN2A
43 carcinosarcoma 30.7 TP53 PTEN KRT7 HRAS ERBB2 EGFR
44 papillary adenocarcinoma 30.6 TP53 KRT7 ERBB2 CDH1
45 keratosis 30.6 TP53 HRAS FGFR3 CDKN2A
46 paget disease, extramammary 30.6 KRT7 KRT20 ERBB2
47 cystadenocarcinoma 30.6 TP53 KRT7 HRAS ERBB2 BRAF
48 benign mesothelioma 30.6 KRT7 KRT20 CDKN2A
49 signet ring cell adenocarcinoma 30.6 TP53 KRT7 KRT20 HRAS ERBB2 CDH1
50 adenoma 30.6 TP53 MKI67 KRT7 KRT20 CDKN2A CDH1

Graphical network of the top 20 diseases related to Transitional Cell Carcinoma:



Diseases related to Transitional Cell Carcinoma

Symptoms & Phenotypes for Transitional Cell Carcinoma

GenomeRNAi Phenotypes related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.41 EGFR HRAS BRAF
2 Decreased viability GR00055-A-2 10.41 EGFR HRAS BRAF
3 Decreased viability GR00106-A-0 10.41 ERBB3
4 Decreased viability GR00221-A-1 10.41 CDH1 CDKN2A EGFR FGFR3 HRAS
5 Decreased viability GR00221-A-2 10.41 FGFR3 HRAS ERBB3 EPHB2
6 Decreased viability GR00221-A-3 10.41 CDKN2A FGFR3 HRAS ERBB2 EPHB2
7 Decreased viability GR00221-A-4 10.41 CDKN2A EGFR BRAF ERBB2 ERBB3
8 Decreased viability GR00249-S 10.41 FGFR3 BRAF
9 Decreased viability GR00301-A 10.41 CDH1 BRAF ERBB3
10 Decreased viability GR00342-S-1 10.41 EPHB2
11 Decreased viability GR00381-A-1 10.41 BRAF
12 Decreased viability GR00386-A-1 10.41 EPHB2
13 Decreased viability GR00402-S-2 10.41 CDH1 EPHB2
14 Decreased cell migration GR00055-A-1 9.55 EPHB2 FGFR3
15 Decreased cell migration GR00055-A-3 9.55 BRAF EGFR HRAS
16 Reduced mammosphere formation GR00396-S 9.23 BRAF BRINP1 CDH1 EGFR ERBB3 HRAS

MGI Mouse Phenotypes related to Transitional Cell Carcinoma:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.38 BRAF BRINP1 CDH1 CDKN2A EGFR ERBB2
2 cellular MP:0005384 10.36 BRAF BRINP1 CDH1 CDKN2A EGFR EPHB2
3 growth/size/body region MP:0005378 10.34 BRAF BRINP1 CDH1 CDKN2A EGFR EPHB2
4 digestive/alimentary MP:0005381 10.28 BRAF CDH1 CDKN2A EGFR EPHB2 ERBB2
5 mortality/aging MP:0010768 10.28 BRAF BRINP1 CDH1 CDKN2A EGFR EPHB2
6 endocrine/exocrine gland MP:0005379 10.21 BRAF CDH1 CDKN2A EGFR EPHB2 ERBB2
7 embryo MP:0005380 10.18 BRAF CDH1 CDKN2A EGFR ERBB2 ERBB3
8 integument MP:0010771 10.16 BRAF CDH1 CDKN2A EGFR ERBB2 ERBB3
9 neoplasm MP:0002006 10.07 BRAF CDH1 CDKN2A EGFR ERBB2 ERBB3
10 muscle MP:0005369 10.01 BRAF CDKN2A EGFR ERBB2 ERBB3 HRAS
11 normal MP:0002873 10 BRAF CDH1 EGFR ERBB2 ERBB3 FGFR3
12 no phenotypic analysis MP:0003012 9.92 BRINP1 CDH1 CDKN2A EGFR FGFR3 HRAS
13 renal/urinary system MP:0005367 9.65 BRAF EGFR EPHB2 FGFR3 HRAS KRT7
14 pigmentation MP:0001186 9.63 BRAF CDKN2A EGFR ERBB3 PTEN TP53
15 respiratory system MP:0005388 9.28 BRAF CDKN2A EGFR ERBB2 ERBB3 FGFR3

Drugs & Therapeutics for Transitional Cell Carcinoma

Drugs for Transitional Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 238)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
2
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
3 Calciferol Phase 4
4
Methylcobalamin Approved, Investigational Phase 3 13422-55-4
5
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
7
Aminolevulinic acid Approved Phase 3 106-60-5 137
8
Panitumumab Approved, Investigational Phase 3 339177-26-3 50070211
9
Topotecan Approved, Investigational Phase 2, Phase 3 123948-87-8, 119413-54-6 60700
10
Lenvatinib Approved, Investigational Phase 3 417716-92-8
11
ramucirumab Approved, Investigational Phase 3 947687-13-0
12
Tranexamic Acid Approved Phase 2, Phase 3 1197-18-8 5526
13
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
14
Gemcitabine Approved Phase 3 95058-81-4 60750
15
Valrubicin Approved Phase 2, Phase 3 56124-62-0 41744
16
Gefitinib Approved, Investigational Phase 3 184475-35-2 123631
17
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
18
Cephalexin Approved, Investigational, Vet_approved Phase 3 15686-71-2 27447
19
Levulinic acid Experimental Phase 3 123-76-2 11579
20
Paclitaxel poliglumex Experimental, Investigational Phase 3 263351-82-2
21
Cediranib Investigational Phase 3 288383-20-0 9933475
22
Maleic acid Experimental Phase 3 110-16-7 444266
23 Nutrients Phase 3
24 Trace Elements Phase 3
25 Micronutrients Phase 3
26 Hematinics Phase 3
27 Antiemetics Phase 3
28 Antineoplastic Agents, Hormonal Phase 3
29 Anti-Inflammatory Agents Phase 3
30 Gastrointestinal Agents Phase 3
31 glucocorticoids Phase 3
32 BB 1101 Phase 3
33 Carotenoids Phase 3
34 Vitamins Phase 3
35 Photosensitizing Agents Phase 3
36 Mitogens Phase 3
37 topoisomerase I inhibitors Phase 2, Phase 3
38 Halichondrin B Phase 3
39 Anesthetics Phase 3
40 Fibrinolytic Agents Phase 2, Phase 3
41 Antifibrinolytic Agents Phase 2, Phase 3
42 Hemostatics Phase 2, Phase 3
43 Coagulants Phase 2, Phase 3
44 taxane Phase 3
45 Pharmaceutical Solutions Phase 3
46 Immunosuppressive Agents Phase 3
47 Immunologic Factors Phase 3
48 Antiviral Agents Phase 3
49 Antimetabolites Phase 3
50 Anti-Infective Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 474)
# Name Status NCT ID Phase Drugs
1 Pilot Study of the Biological Effects of Vitamin D in Patients With Resectable Urinary Tract Urothelial Carcinoma Recruiting NCT04197089 Phase 4 Vitamin D
2 A Randomised Phase II/III Study of Cabazitaxel Versus Vinflunine in Metastatic or Locally Advanced Transitional Cell Carcinoma of the Urothelium Unknown status NCT01830231 Phase 2, Phase 3 Cabazitaxel;Vinflunine
3 Adjuvant vs. Progression-Triggered Treatment With Gemcitabine After Radical Cystectomy for Locally Advanced Transitional Cell Carcinoma of the Bladder in Patients Not Suitable for Cisplatin-Based Chemotherapy - A Phase 3 Study Unknown status NCT00146276 Phase 3 gemcitabine
4 A Prospective Randomized Phase III Trial of Maintenance Pemetrexed Versus Observation in Patients With Recurrent or Metastatic Urothelial Carcinoma Who Completed First Line Platinum-based Chemotherapy Without Disease Progression Unknown status NCT03193788 Phase 3 pemetrexed;Folic Acid;Vitamin B12 Injection;Dexamethasone
5 Can Diet and Physical Activity Modulate Ovarian, Fallopian Tube and Primary Peritoneal Cancer Progression-Free Survival? Unknown status NCT00719303 Phase 3
6 A Randomised Trial of Radical Chemo/Radiotherapy vs Radiotherapy Alone in the Definitive Management of Localised Muscle Invasive TCC of the Urinary Bladder Completed NCT00330499 Phase 3 Cisplatin
7 Prospective, Randomized Phase III Trial of I.V. Vinflunine Plus Best Supportive Care as Second Line Therapy Versus Best Supportive Care After a Platinum-containing Regimen, in Patients With Advanced Transitional Cell Carcinoma of Urothelial Tract Completed NCT00315237 Phase 3 vinflunine and best supportive care
8 A Laser Detection for Bladder Cancer by (Photodynamic) Spectra of Urine Completed NCT02101931 Phase 3 Amino levulinic Acid
9 Cabazitaxel in Platinum Pre-treated Patients With Locally Advanced or Metastatic Transitional Cell Carcinoma Who Developed Disease Progression Within 12 Months of Platinum Based Chemotherapy. Completed NCT01668459 Phase 2, Phase 3 Cabazitaxel
10 A Multicenter, Randomized Double-Blind Phase II/III Study in the First-Line Treatment of Advanced Transitional Cell Carcinoma (TCC) of the Urothelium Comparing Vinflunine/Gemcitabine to Placebo/Gemcitabine in Patients Who Are Ineligible to Receive Cisplatin-Based Therapy Completed NCT00389155 Phase 2, Phase 3 Vinflunine;Gemcitabine
11 Randomized Phase III Trial Comparing Immediate Versus Deferred Chemotherapy After Radical Cystectomy in Patients With pT3-pT4, and/or N+M0 Transitional Cell Carcinoma (TCC) of the Bladder Completed NCT00028756 Phase 3 doxorubicin hydrochloride;gemcitabine hydrochloride;vinblastine sulfate;methotrexate;cisplatin
12 A Phase 3 Multicenter Trial Evaluating the Efficacy and Safety of UGN-101 on Ablation of Upper Urinary Tract Urothelial Carcinoma Completed NCT02793128 Phase 3 UGN-101 instillations
13 A Randomized, Open Label, Multicenter Phase 2/3 Study to Evaluate the Efficacy and Safety of Rogaratinib (BAY1163877) Compared to Chemotherapy in Patients With FGFR-positive Locally Advanced or Metastatic Urothelial Carcinoma Who Have Received Prior Platinum-containing Chemotherapy Completed NCT03410693 Phase 2, Phase 3 Rogaratinib (BAY1163877);Chemotherapy
14 A Phase 3 Randomized, Double-Blind Trial of Pembrolizumab (MK-3475) in Combination With Epacadostat (INCB024360) or Placebo in Participants With Cisplatin-ineligible Urothelial Carcinoma (KEYNOTE-672/ECHO-307) Completed NCT03361865 Phase 3 Pembrolizumab;Epacadostat;Placebo
15 Randomized Phase III Study Comparing Paclitaxel/Cisplatin/Gemcitabine and Cisplatin/Gemcitabine in Patients With Metastatic or Locally Advanced Urothelial Cancer Without Prior Systemic Therapy Completed NCT00022191 Phase 3 cisplatin;gemcitabine hydrochloride;paclitaxel
16 Randomized Phase II/III Study Assessing Gemcitabine/Carboplatin And Methotrexate/Carboplatin/Vinblastine In Previously Untreated Patients With Advanced Urothelial Cancer Ineligible For Cisplatin Based Chemotherapy Completed NCT00014274 Phase 2, Phase 3 carboplatin;gemcitabine hydrochloride;methotrexate;vinblastine sulfate
17 A Phase III Trial of Carboplatin and Paclitaxel Plus Placebo Versus Carboplatin and Paclitaxel Plus Concurrent Bevacizumab (NSC # 704865) Followed by Placebo, Versus Carboplatin and Paclitaxel Plus Concurrent and Extended Bevacizumab, in Women With Newly Diagnosed, Previously Untreated, Stage III or IV Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancer Completed NCT00262847 Phase 3 Carboplatin;Paclitaxel
18 Phase III Trial of Methotrexate, Vinblastine, Doxorubicin and Cisplatin vs Carboplatin and Paclitaxel in Advanced Carcinoma of the Urothelium Completed NCT00003376 Phase 3 carboplatin;cisplatin;doxorubicin hydrochloride;methotrexate;paclitaxel;vinblastine
19 Intensified Methotrexate, Vinblastine, Doxorubicin and Cisplatin +/-Panitumumab as First-line Treatment of Advanced Urothelial Carcinoma in Patients Without Harvey Nor Kirsten Rat Sarcoma Viral Oncogene Homolog Mutations. Phase II Study Completed NCT02818725 Phase 3 Chemotherapy;Panitumumab
20 A Phase 3 Randomized, Double-Blind Clinical Study of Pembrolizumab + Epacadostat vs Pembrolizumab + Placebo as a Treatment for Recurrent or Progressive Metastatic Urothelial Carcinoma in Patients Who Have Failed a First-Line Platinum-containing Chemotherapy Regimen for Advanced/Metastatic Disease (KEYNOTE-698/ECHO-303) Completed NCT03374488 Phase 3 Pembrolizumab;Epacadostat;Placebo
21 Phase III Study Comparing Sequential Chemotherapy (AG-ITP) To Cisplatin And Gemcitabine As Adjuvant Treatment After Cystectomy For Transitional Cell Carcinoma Of The Bladder Completed NCT00014534 Phase 3 cisplatin;doxorubicin hydrochloride;gemcitabine hydrochloride
22 A Phase III Randomized Trial of Either M-VAC or Paclitaxel + Carboplatin as Postoperative Adjuvant Therapy in Patients With Muscle-Invasive Transitional Cell Carcinoma of the Bladder at High-Risk for Relapse Completed NCT00003701 Phase 3 carboplatin;cisplatin;doxorubicin hydrochloride;methotrexate;paclitaxel;vinblastine sulfate
23 Megadose Vitamins as Chemoprevention of Transitional Cell Carcinoma of the Bladder Completed NCT00003623 Phase 3
24 Randomised Trial of Selective Bladder Preservation Against Radical Excision (Cystectomy) in Muscle Invasive T2/T3 Transitional Cell Carcinoma of the Bladder - Feasibility Study Completed NCT00867347 Phase 3
25 A Randomized Phase II/III Study of the Combination of Cediranib and Olaparib Compared to Cediranib or Olaparib Alone, or Standard of Care Chemotherapy in Women With Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (COCOS) Recruiting NCT02502266 Phase 2, Phase 3 Cediranib;Cediranib Maleate;Olaparib;Paclitaxel;Pegylated Liposomal Doxorubicin Hydrochloride;Topotecan;Topotecan Hydrochloride
26 A Randomized, Controlled, Open-Label Study of the Efficacy, Durability, and Safety of UGN-102 With or Without TURBT in Patients With Low Grade Intermediate Risk Non-Muscle-Invasive Bladder Cancer (LG IR NMIBC) Recruiting NCT04688931 Phase 3 UGN-102
27 A Phase 3, Randomized, Double-blind Study to Compare the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Lenvatinib (E7080/MK-7902) Versus Pembrolizumab and Placebo as First Line Treatment for Locally Advanced or Metastatic Urothelial Carcinoma in Cisplatin-ineligible Participants Whose Tumors Express PD-L1, and in Participants Ineligible for Any Platinum-containing Chemotherapy Regardless of PD-L1 Expression (LEAP-011) Recruiting NCT03898180 Phase 3 Lenvatinib;Placebo for lenvatinib
28 Duration of Immune Checkpoint Therapy in Locally Advanced or Metastatic Urothelial Carcinoma: A Randomized Phase 3 Non-Inferiority Trial Recruiting NCT04637594 Phase 3 Pembrolizumab;Nivolumab;Atezolizumab;Durvalumab;Avelumab
29 A Phase 3, Multi-center, Randomized, Double-Blind, Placebo-Controlled Study of Either Cisplatin or Carboplatin +Gemcitabine + Tislelizumab Compared With Either Cisplatin or Carboplatin + Gemcitabine + Placebo as First-line Treatment for Patients With Locally Advanced or Metastatic Urothelial Carcinoma Recruiting NCT03967977 Phase 3 Tislelizumab;Placebo;Cisplatin;Gemcitabine Hydrochloride;Carboplatin
30 A Phase III Randomized Trial of Eribulin (NSC #707389) With or Without Gemcitabine Versus Standard of Care (Physician's Choice) for Treatment of Metastatic Urothelial Carcinoma Refractory to, or Ineligible for, Anti PD1/PDL1 Therapy Recruiting NCT04579224 Phase 3 Docetaxel;Eribulin Mesylate;Gemcitabine Hydrochloride;Paclitaxel
31 Neoadjuvant Chemotherapy in Upper Tract Urothelial Cancer: A Multicentre, Feasibility Pilot Trial Recruiting NCT04574960 Phase 3 Gemcitabine;Cisplatin;Carboplatin
32 Laparoscopic Cytoreduction After Neoadjuvant Chemotherapy Recruiting NCT04575935 Phase 3 Chemotherapy
33 Four Cycles of Cisplatin-Based Chemotherapy in Metastatic Urothelial Carcinoma Compared to Six Cycles: Randomized Phase III Trial - FOCUS Study - Recruiting NCT03296306 Phase 3 Treatment duration of cisplatin based chemotherapy
34 A Randomized Open-Label Phase III Study of Sacituzumab Govitecan Versus Treatment of Physician's Choice in Subjects With Metastatic or Locally Advanced Unresectable Urothelial Cancer (TROPiCS-04) Recruiting NCT04527991 Phase 3 sacituzumab govitecan 10 mg/kg IV q21 day dosing;Treatment of Physician's Choice of either paclitaxel 175 mg/m2, docetaxel 75 mg/m2 or vinflunine 320 mg/m2
35 Phase III Randomized Adjuvant Study of Pembrolizumab in Muscle InvaSive and Locally Advanced Urothelial CaRcinoma (AMBASSADOR) Versus Observation Recruiting NCT03244384 Phase 3
36 Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial of Infigratinib for the Adjuvant Treatment of Subjects With Invasive Urothelial Carcinoma With Susceptible FGFR3 Genetic Alterations (PROOF 302) Recruiting NCT04197986 Phase 3 Infigratinib;Placebo
37 A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Ramucirumab Plus Docetaxel Versus Placebo Plus Docetaxel in Patients With Locally Advanced or Unresectable or Metastatic Urothelial Carcinoma Who Progressed on or After Platinum-Based Therapy Active, not recruiting NCT02426125 Phase 3 Ramucirumab;Docetaxel;Placebo
38 Tranexamic Acid During Cystectomy Trial (TACT) Active, not recruiting NCT01869413 Phase 2, Phase 3 Tranexamic Acid;Placebo
39 A Phase III Randomised Trial of Peri-Operative Chemotherapy Versus sUrveillance in Upper Tract Urothelial Cancer Active, not recruiting NCT01993979 Phase 3 Chemotherapy
40 A Randomized Double-Blinded Phase III Study Comparing Gemcitabine, Cisplatin, and Bevacizumab to Gemcitabine, Cisplatin, and Placebo in Patients With Advanced Transitional Cell Carcinoma Active, not recruiting NCT00942331 Phase 3 Cisplatin;Gemcitabine Hydrochloride
41 A Phase III, Open-Label, Multicenter, Randomized Study of Atezolizumab (Anti-PD-L1 Antibody) Versus Observation as Adjuvant Therapy in Patients With High-Risk Muscle-Invasive Urothelial Carcinoma After Surgical Resection Active, not recruiting NCT02450331 Phase 3 Atezolizumab
42 GOG-0262: A Phase III Trial of Every-3-Weeks Paclitaxel Versus Dose Dense Weekly Paclitaxel in Combination With Carboplatin With or Without Concurrent and Consolidation Bevacizumab (NSC #704865) in the Treatment of Primary Stage II, III or IV Epithelial Ovarian, Peritoneal or Fallopian Tube Cancer and ACRIN 6695: Perfusion CT Imaging to Evaluate Treatment Response in Patients Participating in GOG-0262 Active, not recruiting NCT01167712 Phase 3 Carboplatin;Paclitaxel
43 A Randomized Phase III Trial of Maintenance Chemotherapy Comparing 12, Monthly Cycles of Single Agent Paclitaxel or CT-2103 Versus No Treatment Until Documented Relapse in Women With Advanced Ovarian, Primary Peritoneal or Fallopian Tube Cancer Who Achieve a Complete Clinical Response to Primary Platinum/Taxane Chemotherapy Active, not recruiting NCT00108745 Phase 3 Paclitaxel;Paclitaxel Poliglumex
44 A Phase III, Multicenter, Randomized, Placebo-Controlled Study of Atezolizumab (Anti-PD-L1 Antibody) as Monotherapy and in Combination With Platinum-Based Chemotherapy in Patients With Untreated Locally Advanced or Metastatic Urothelial Carcinoma Active, not recruiting NCT02807636 Phase 3 Atezolizumab;Carboplatin;Gemcitabine;Cisplatin
45 S1602, A Phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming With Intradermal BCG Before Intravesical Therapy for BCG-Naive High-Grade Non-muscle Invasive Bladder Cancer Active, not recruiting NCT03091660 Phase 3
46 A Phase III Randomized, Controlled Clinical Trial of Pembrolizumab With or Without Platinum-Based Combination Chemotherapy Versus Chemotherapy in Subjects With Advanced or Metastatic Urothelial Carcinoma Active, not recruiting NCT02853305 Phase 3 Cisplatin;Carboplatin;Gemcitabine
47 A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel (or Gemcitabine) Alone or in Combination With Bevacizumab (NSC #704865) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer. NCI-Supplied Agents: Bevacizumab (NSC #704865) Active, not recruiting NCT00565851 Phase 3 Carboplatin;Docetaxel;Gemcitabine Hydrochloride;Paclitaxel
48 A Phase III Study Comparing Single-Agent Olaparib or the Combination of Cediranib and Olaparib to Standard Platinum-Based Chemotherapy in Women With Recurrent Platinum-Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Active, not recruiting NCT02446600 Phase 3 Carboplatin;Cediranib Maleate;Gemcitabine;Gemcitabine Hydrochloride;Olaparib;Paclitaxel;Pegylated Liposomal Doxorubicin Hydrochloride
49 A Phase III Clinical Trial of Bevacizumab With IV Versus IP Chemotherapy in Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma Active, not recruiting NCT00951496 Phase 3 Carboplatin;Carboplatin;Cisplatin;Paclitaxel;Paclitaxel
50 A Phase III, Randomized, Double-blind, Placebo-controlled, Multi-center Clinical Study to Evaluate the Efficacy and Safety of Toripalimab Injection (JS001) in Combination With Standard Chemotherapy Versus Placebo in Combination With Standard Chemotherapy as the 1st-line Therapy for Treatment-naive Subjects With PD-L1-positive Locally Advanced or Metastatic Urothelial Carcinoma Not yet recruiting NCT04568304 Phase 3 Gemcitabine Hydrochloride for Injection;Cisplatin for Injection / Carboplatin Injection;Placebo

Search NIH Clinical Center for Transitional Cell Carcinoma

Cochrane evidence based reviews: carcinoma, transitional cell

Genetic Tests for Transitional Cell Carcinoma

Anatomical Context for Transitional Cell Carcinoma

MalaCards organs/tissues related to Transitional Cell Carcinoma:

40
Prostate, Kidney, Lymph Node, Ovary, Endothelial, Lung, Bone

Publications for Transitional Cell Carcinoma

Articles related to Transitional Cell Carcinoma:

(show top 50) (show all 8656)
# Title Authors PMID Year
1
Potential of molecular targeted therapy of HER-2 and Cox-2 for invasive transitional cell carcinoma of the urinary bladder. 61 54
20428812 2010
2
Sarcomatoid carcinoma of the urinary bladder: a case report with immunohistochemical and molecular genetic analysis. 61 54
19521796 2010
3
Isoenzyme profile of glutathione transferases in transitional cell carcinoma of upper urinary tract. 61 54
20403581 2010
4
Results of the Southwest Oncology Group phase II evaluation (study S0031) of ZD1839 for advanced transitional cell carcinoma of the urothelium. 54 61
19888985 2010
5
p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. 61 54
20068172 2010
6
[Expressions of survivin and the splice variants survivin-2B and survivin-DeltaEx3 in bladder cancer and their clinical significance]. 54 61
19895744 2009
7
Role of polysomy 17 in transitional cell carcinoma of the bladder: immunohistochemical study of HER2/neu expression and fish analysis of c-erbB-2 gene and chromosome 17. 61 54
19443884 2009
8
Selection of optimal antisense accessible sites of uroplakin II mRNA for bladder urothelium. 54 61
19513619 2009
9
[Expression and clinical significance of nuclear matrix protein 22 and cytokeratin 18 in transitional cell carcinoma of the bladder]. 54 61
19615282 2009
10
A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells. 54 61
19115207 2009
11
Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells. 54 61
19287971 2009
12
Differential expression of survivin and its splice variants, survivin-DeltaEx3 and survivin-2B, in bladder cancer. 54 61
19186007 2009
13
Soluble form of carbonic anhydrase IX (CAIX) in transitional cell carcinoma of urinary tract. 54 61
19473055 2009
14
Implications of p53 gene mutations on patient survival in transitional cell carcinoma of the bladder: a long-term study. 61 54
18367096 2008
15
Identification of survivin, an inhibitor of apoptosis, in canine urinary bladder transitional cell carcinoma. 54 61
19178674 2008
16
Systemic therapy for unresectable and metastatic transitional cell carcinoma of the urothelium: first-line and beyond. 61 54
18685414 2008
17
Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situ. 61 54
18547617 2008
18
p63 expression in ovarian tumours: immunopositivity in metastatic transitional cell carcinoma of the ovary. 61 54
18518899 2008
19
DNA polymorphisms in exon 1 and promoter of the CDH1 gene and relevant risk of transitional cell carcinoma of the urinary bladder. 61 54
18384629 2008
20
RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. 54 61
18676844 2008
21
The role of carbonic anhydrase IX as a molecular marker for transitional cell carcinoma of the bladder. 61 54
18430124 2008
22
Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of bladder transitional cell carcinoma to Cisplatin. 61 54
18538698 2008
23
Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin. 54 61
18355860 2008
24
SNPs of GSTM1, T1, P1, epoxide hydrolase and DNA repair enzyme XRCC1 and risk of urinary transitional cell carcinoma in southwestern Taiwan. 54 61
18199464 2008
25
Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer. 61 54
18449376 2008
26
Survivin: a promising biomarker for detection and prognosis of bladder cancer. 61 54
17962949 2008
27
Inhibition of thromboxane synthase activity modulates bladder cancer cell responses to chemotherapeutic agents. 54 61
17603559 2008
28
Expression of vascular endothelial growth factor, receptor KDR and p53 protein in transitional cell carcinoma of the bladder. 61 54
18645275 2008
29
Downregulation of survivin is associated with reductions in TNF receptors' mRNA and protein and alterations in nuclear factor kappa B signaling in urothelial cancer cells. 61 54
18058462 2007
30
Expression of CD44s and CD44v6 in transitional cell carcinomas of the urinary bladder: comparison with tumour grade, proliferative activity and p53 immunoreactivity of tumour cells. 61 54
18092951 2007
31
Expression of cyclooxygenase-2, P-glycoprotein and multi-drug resistance-associated protein in canine transitional cell carcinoma. 54 61
17316722 2007
32
Expression of prostate-specific membrane antigen in tumor-associated neovasculature of renal neoplasms. 54 61
17826525 2007
33
Bacillus Calmette-Guérin induces p21 expression in human transitional carcinoma cell lines via an immediate early, p53 independent pathway. 61 54
17483019 2007
34
Predictive value of p53 and pRb expression in superficial bladder cancer patients treated with BCG and interferon-alpha. 61 54
17311305 2007
35
Expression of p63 in thymomas and normal thymus. 54 61
17276940 2007
36
Cyclooxygenase-2 in transitional cell carcinoma--a legitimate target? 61 54
17296349 2007
37
Expression of cyclooxygenase-2 in normal urothelium, and superficial and advanced transitional cell carcinoma of bladder. 61 54
17296438 2007
38
Prospective evaluation of p53 as a prognostic marker in T1 transitional cell carcinoma of the bladder. 61 54
17155984 2007
39
Predictive value of cell cycle biomarkers in nonmuscle invasive bladder transitional cell carcinoma. 54 61
17222615 2007
40
EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder. 54 61
17541304 2007
41
Overexpression of HER-2/neu oncogene and transitional cell carcinoma of bladder. 61 54
17987577 2007
42
Urinary cytokeratin 20 mRNA expression has the potential to predict recurrence in superficial transitional cell carcinoma of the bladder. 54 61
16473461 2007
43
P53 overexpression in bladder urothelial neoplasms: new aspect of World Health Organization/International Society of Urological Pathology classification. 54 61
18270948 2007
44
Correlation of cyclin D1 and E1 expression with bladder cancer presence, invasion, progression, and metastasis. 61 54
16949911 2006
45
Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer. 54 61
17133271 2006
46
Assessing interactions between mdm-2, p53, and bcl-2 as prognostic variables in muscle-invasive bladder cancer treated with neo-adjuvant chemotherapy followed by locoregional surgical treatment. 61 54
16984978 2006
47
Overexpression of PAX5 in oral carcinogenesis. 61 54
17016584 2006
48
The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder. 54 61
17024120 2006
49
The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population. 61 54
17381051 2006
50
Regularly methylated novel pro-apoptotic genes associated with recurrence in transitional cell carcinoma of the bladder. 61 54
16642478 2006

Variations for Transitional Cell Carcinoma

Copy number variations for Transitional Cell Carcinoma from CNVD:

7 (show top 50) (show all 92)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 26136 1 197500000 205300000 Amplification LRRN2 Urothelial cell carcinoma
2 26141 1 197500000 205300000 Amplification MDM4 Urothelial cell carcinoma
3 26154 1 197500000 205300000 Loss Urothelial cell carcinoma
4 42679 10 3800000 6700000 Amplification PFKFB3 Urothelial cell carcinoma
5 49670 11 110000000 115400000 Loss ANKK1 Urothelial cell carcinoma
6 49671 11 110000000 115400000 Loss DRD2 Urothelial cell carcinoma
7 49672 11 110000000 115400000 Loss NCAM1 Urothelial cell carcinoma
8 49673 11 110000000 115400000 Loss TTC12 Urothelial cell carcinoma
9 52333 11 16100000 21600000 Loss PLEKHA7 Urothelial cell carcinoma
10 58688 11 69200000 70700000 Amplification CCND1 Urothelial cell carcinoma
11 58689 11 69200000 70700000 Amplification FGF19 Urothelial cell carcinoma
12 58690 11 69200000 70700000 Amplification FGF3 Urothelial cell carcinoma
13 58692 11 69200000 70700000 Amplification FGF4 Urothelial cell carcinoma
14 58694 11 69200000 70700000 Amplification LTO1 Urothelial cell carcinoma
15 58695 11 69200000 70700000 Amplification TPCN2 Urothelial cell carcinoma
16 58889 11 70700000 74900000 Amplification Urothelial cell carcinoma
17 58890 11 70700000 74900000 Amplification SHANK2-AS3 Urothelial cell carcinoma
18 58891 11 70700000 74900000 Amplification SHANK2 Urothelial cell carcinoma
19 64483 12 128700000 132349534 Loss FZD10 Urothelial cell carcinoma
20 69470 12 55200000 56300000 Amplification ARHGAP9 Urothelial cell carcinoma
21 69471 12 55200000 56300000 Amplification DCTN2 Urothelial cell carcinoma
22 69472 12 55200000 56300000 Amplification GLI1 Urothelial cell carcinoma
23 69473 12 55200000 56300000 Amplification INHBC Urothelial cell carcinoma
24 69474 12 55200000 56300000 Amplification KIF5A Urothelial cell carcinoma
25 69475 12 55200000 61400000 Amplification CDK4 Urothelial cell carcinoma
26 69476 12 55200000 61400000 Amplification METTL1 Urothelial cell carcinoma
27 69477 12 55200000 61400000 Amplification TSFM Urothelial cell carcinoma
28 69795 12 56300000 61400000 Amplification TAFA2 Urothelial cell carcinoma
29 69796 12 56300000 61400000 Amplification SLC16A7 Urothelial cell carcinoma
30 70900 12 66000000 69800000 Amplification CNOT2 Urothelial cell carcinoma
31 70901 12 66000000 69800000 Amplification CPM Urothelial cell carcinoma
32 70902 12 66000000 69800000 Amplification IFNG Urothelial cell carcinoma
33 70903 12 66000000 69800000 Amplification IL22 Urothelial cell carcinoma
34 70904 12 66000000 69800000 Amplification IL26 Urothelial cell carcinoma
35 70910 12 66000000 69800000 Amplification MDM2 Urothelial cell carcinoma
36 70911 12 66000000 69800000 Amplification TSPAN8 Urothelial cell carcinoma
37 71411 12 69800000 74100000 Amplification LGR5 Urothelial cell carcinoma
38 71412 12 69800000 74100000 Amplification THAP2 Urothelial cell carcinoma
39 71413 12 69800000 74100000 Amplification TMEM19 Urothelial cell carcinoma
40 71414 12 69800000 74100000 Amplification TPH2 Urothelial cell carcinoma
41 71668 12 74100000 78700000 Amplification NAV3 Urothelial cell carcinoma
42 72907 12 87500000 91200000 Amplification KITLG Urothelial cell carcinoma
43 73109 12 91200000 94800000 Amplification PLXNC1 Urothelial cell carcinoma
44 79797 13 77800000 86500000 Loss Urothelial cell carcinoma
45 94764 15 70400000 73100000 Loss NPTN Urothelial cell carcinoma
46 109762 17 28800000 35600000 Amplification ERBB2 Urothelial cell carcinoma
47 109763 17 28800000 35600000 Amplification TCAP Urothelial cell carcinoma
48 123109 18 66900000 71300000 Loss Urothelial cell carcinoma
49 123110 18 66900000 71300000 Loss TSHZ1 Urothelial cell carcinoma
50 123111 18 66900000 71300000 Loss ZADH2 Urothelial cell carcinoma

Expression for Transitional Cell Carcinoma

Search GEO for disease gene expression data for Transitional Cell Carcinoma.

Pathways for Transitional Cell Carcinoma

Pathways related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 TP53 PTEN HRAS FGFR3 ERBB3 ERBB2
2
Show member pathways
13.74 TP53 HRAS FGFR3 ERBB3 ERBB2 EPHB2
3
Show member pathways
13.58 TP53 HRAS FGFR3 ERBB3 ERBB2 EPHB2
4
Show member pathways
13.54 KRT7 KRT20 HRAS FGFR3 ERBB3 ERBB2
5
Show member pathways
13.49 TP53 PTEN HRAS FGFR3 ERBB3 ERBB2
6
Show member pathways
13.45 TP53 PTEN HRAS FGFR3 ERBB3 ERBB2
7
Show member pathways
13.39 TP53 HRAS FGFR3 ERBB3 ERBB2 EGFR
8
Show member pathways
13.35 PTEN HRAS FGFR3 ERBB3 ERBB2 EPHB2
9
Show member pathways
13.32 HRAS FGFR3 ERBB3 ERBB2 EPHB2 EGFR
10
Show member pathways
13.25 TP53 PTEN HRAS ERBB3 ERBB2 EGFR
11
Show member pathways
13.14 TP53 PTEN FGFR3 ERBB3 ERBB2 EGFR
12
Show member pathways
13.1 TP53 PTEN HRAS FGFR3 EGFR BRAF
13
Show member pathways
13.05 TP53 PTEN HRAS FGFR3 ERBB3 ERBB2
14
Show member pathways
12.99 FGFR3 ERBB3 ERBB2 EPHB2 EGFR CDH1
15
Show member pathways
12.94 PTEN HRAS ERBB3 ERBB2 EGFR BRAF
16
Show member pathways
12.93 PTEN HRAS FGFR3 ERBB3 ERBB2 EGFR
17
Show member pathways
12.89 TP53 PTEN HRAS ERBB2 EGFR CDKN2A
18 12.81 TP53 PTEN HRAS FGFR3 ERBB2 EGFR
19 12.8 TP53 HRAS FGFR3 ERBB3 ERBB2 EGFR
20
Show member pathways
12.76 HRAS FGFR3 EGFR CDH1 BRAF
21
Show member pathways
12.76 TP53 PTEN HRAS FGFR3 ERBB3 ERBB2
22
Show member pathways
12.76 TP53 PTEN HRAS ERBB2 EGFR CDKN2A
23
Show member pathways
12.74 TP53 PTEN HRAS ERBB3 ERBB2 CDH1
24
Show member pathways
12.61 TP53 PTEN HRAS FGFR3 ERBB3 ERBB2
25
Show member pathways
12.57 TP53 PTEN HRAS FGFR3 EGFR CDH1
26
Show member pathways
12.51 TP53 HRAS FGFR3 ERBB3 ERBB2 EGFR
27 12.46 TP53 PTEN HRAS FGFR3 ERBB3 ERBB2
28 12.42 FGFR3 ERBB3 ERBB2 EGFR
29
Show member pathways
12.41 HRAS FGFR3 ERBB3 ERBB2 EPHB2 EGFR
30
Show member pathways
12.38 TP53 PTEN HRAS ERBB2 EGFR
31 12.37 TP53 PTEN HRAS CDKN2A
32
Show member pathways
12.37 HRAS ERBB3 ERBB2 EGFR CDH1 BRAF
33
Show member pathways
12.35 HRAS ERBB3 ERBB2 EGFR
34 12.34 TP53 HRAS ERBB3 ERBB2 EGFR BRAF
35
Show member pathways
12.33 TP53 HRAS EGFR BRAF
36
Show member pathways
12.33 TP53 PTEN HRAS FGFR3 ERBB3 ERBB2
37
Show member pathways
12.32 HRAS ERBB3 ERBB2 EGFR
38 12.26 PTEN HRAS ERBB2 EGFR BRAF
39 12.22 TP53 EGFR CDH1 BRAF
40 12.22 TP53 PTEN EGFR CDH1 BRAF
41
Show member pathways
12.21 TP53 PTEN HRAS ERBB3 ERBB2 EGFR
42 12.2 TP53 PTEN HRAS CDKN2A
43 12.2 FGFR3 ERBB3 ERBB2 EPHB2 EGFR
44
Show member pathways
12.19 TP53 PTEN HRAS FGFR3 ERBB3 ERBB2
45
Show member pathways
12.18 PTEN HRAS ERBB2 EGFR
46
Show member pathways
12.13 PTEN HRAS EGFR BRAF
47
Show member pathways
12.11 HRAS ERBB3 ERBB2 EGFR
48
Show member pathways
12.09 TP53 ERBB3 ERBB2 EGFR BRAF
49 12.04 TP53 PTEN HRAS ERBB2 CDKN2A
50
Show member pathways
12.01 HRAS ERBB3 ERBB2 EGFR

GO Terms for Transitional Cell Carcinoma

Cellular components related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.92 UPK2 UPK1B UPK1A FGFR3 ERBB3 ERBB2
2 receptor complex GO:0043235 9.55 FGFR3 ERBB3 ERBB2 EPHB2 EGFR
3 basal plasma membrane GO:0009925 9.54 ERBB3 ERBB2 EGFR
4 ERBB3:ERBB2 complex GO:0038143 9.26 ERBB3 ERBB2
5 apical plasma membrane GO:0016324 9.23 UPK3A UPK2 UPK1B UPK1A PTEN ERBB3
6 apical plasma membrane urothelial plaque GO:0120001 9.13 UPK3A UPK1B UPK1A

Biological processes related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 10.04 TP53 PTEN KRT20 HRAS FGFR3 CDKN2A
2 protein phosphorylation GO:0006468 10.02 FGFR3 ERBB3 ERBB2 EPHB2 EGFR BRAF
3 positive regulation of cell proliferation GO:0008284 9.97 PTEN HRAS FGFR3 ERBB3 ERBB2 EGFR
4 phosphorylation GO:0016310 9.95 FGFR3 ERBB3 ERBB2 EPHB2 EGFR CDKN2A
5 heart development GO:0007507 9.93 TP53 PTEN ERBB3 ERBB2
6 positive regulation of protein kinase B signaling GO:0051897 9.88 FGFR3 ERBB3 ERBB2 EGFR
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 PTEN HRAS FGFR3 EGFR BRAF
8 cell cycle arrest GO:0007050 9.81 TP53 HRAS CDKN2A BRINP1
9 Ras protein signal transduction GO:0007265 9.8 TP53 HRAS CDKN2A
10 MAPK cascade GO:0000165 9.8 HRAS FGFR3 ERBB3 ERBB2 EGFR BRAF
11 cellular response to drug GO:0035690 9.79 TP53 EGFR BRAF
12 learning or memory GO:0007611 9.79 PTEN EPHB2 EGFR
13 positive regulation of epithelial cell proliferation GO:0050679 9.78 HRAS ERBB2 EGFR
14 positive regulation of MAP kinase activity GO:0043406 9.77 HRAS ERBB2 EGFR
15 phosphatidylinositol 3-kinase signaling GO:0014065 9.71 PTEN ERBB3 ERBB2
16 negative regulation of mitotic cell cycle GO:0045930 9.7 TP53 EGFR BRINP1
17 epithelial cell differentiation GO:0030855 9.67 UPK3A UPK2 UPK1B UPK1A
18 regulation of cell motility GO:2000145 9.65 ERBB3 ERBB2 EGFR
19 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.65 FGFR3 ERBB3 ERBB2 EPHB2 EGFR
20 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.64 TP53 EGFR
21 maternal behavior GO:0042711 9.63 PTEN BRINP1
22 ERBB2 signaling pathway GO:0038128 9.63 ERBB3 ERBB2 EGFR
23 regulation of axon regeneration GO:0048679 9.6 PTEN BRAF
24 negative regulation of ERBB signaling pathway GO:1901185 9.58 ERBB2 EGFR
25 negative regulation of immature T cell proliferation in thymus GO:0033088 9.56 ERBB2 CDKN2A
26 positive regulation of gene expression GO:0010628 9.56 TP53 PTEN HRAS ERBB3 ERBB2 EPHB2
27 positive regulation of kinase activity GO:0033674 9.55 FGFR3 ERBB3 ERBB2 EPHB2 EGFR
28 peptidyl-tyrosine phosphorylation GO:0018108 9.1 FGFR3 ERBB3 ERBB2 EPHB2 EGFR BRAF

Molecular functions related to Transitional Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.37 UPK3A UPK2 UPK1B UPK1A UBIAD1 TP53
2 nucleotide binding GO:0000166 10.08 MKI67 HRAS FGFR3 ERBB3 ERBB2 EPHB2
3 ATP binding GO:0005524 10.03 TP53 MKI67 FGFR3 ERBB3 ERBB2 EPHB2
4 identical protein binding GO:0042802 9.91 TP53 PTEN FGFR3 ERBB3 ERBB2 EPHB2
5 protein kinase activity GO:0004672 9.8 FGFR3 ERBB3 ERBB2 EPHB2 EGFR BRAF
6 kinase activity GO:0016301 9.7 FGFR3 ERBB3 ERBB2 EPHB2 EGFR CDKN2A
7 MDM2/MDM4 family protein binding GO:0097371 9.46 TP53 CDKN2A
8 ErbB-3 class receptor binding GO:0043125 9.4 ERBB3 ERBB2
9 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.35 FGFR3 ERBB3 ERBB2 EPHB2 EGFR
10 protein tyrosine kinase activity GO:0004713 9.1 FGFR3 ERBB3 ERBB2 EPHB2 EGFR BRAF

Sources for Transitional Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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