MCID: TRN007
MIFTS: 43

Transsexualism

Categories: Mental diseases

Aliases & Classifications for Transsexualism

MalaCards integrated aliases for Transsexualism:

Name: Transsexualism 12 45 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10919
ICD9CM 36 302.50
MeSH 45 D014189
ICD10 34 F64.0
UMLS 74 C0040630

Summaries for Transsexualism

Disease Ontology : 12 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards based summary : Transsexualism is related to hyperandrogenism and osteoporosis. An important gene associated with Transsexualism is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are TGF-beta Signaling Pathways and Nuclear Receptor transcription pathway. The drugs Testolactone and Lynestrenol have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and ovary, and related phenotypes are endocrine/exocrine gland and adipose tissue

Related Diseases for Transsexualism

Diseases related to Transsexualism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 hyperandrogenism 29.6 CYP17A1 CYP19A1
2 osteoporosis 29.5 AR CYP19A1 ESR2
3 hypospadias 29.4 AR CYP17A1 SRD5A2
4 gender identity disorder 29.2 AR CYP19A1 ESR2 RFX6 RPGRIP1L
5 prostate cancer 29.0 AR CYP17A1 CYP19A1 ESR2 SRD5A2
6 transsexuality 12.3
7 transvestism 10.4
8 postmenopausal atrophic vaginitis 10.2 AR ESR2
9 vaginitis 10.2 AR ESR2
10 testicular germ cell cancer 10.2 AR ESR2
11 germ cell cancer 10.2 AR ESR2
12 androgen insensitivity, partial 10.2 AR CYP19A1
13 hermaphroditism 10.2 AR SRD5A2
14 progesterone-receptor positive breast cancer 10.2 CYP19A1 ESR2
15 estrogen excess 10.2 CYP19A1 ESR2
16 androgenic alopecia 10.2 AR CYP19A1
17 complete androgen insensitivity syndrome 10.2 AR CYP19A1
18 endometriosis 10.1 CYP19A1 ESR2
19 endometriosis of ovary 10.1 CYP19A1 ESR2
20 prostatic hypertrophy 10.1 AR CYP19A1
21 schizophrenia 10.1
22 gynecomastia 10.1 AR CYP19A1
23 androgen insensitivity syndrome 10.1 AR SRD5A2
24 ductal carcinoma in situ 10.1 AR CYP19A1
25 pituitary adenoma, prolactin-secreting 10.1
26 meningioma, familial 10.1
27 polycystic ovary syndrome 10.1
28 spinal meningioma 10.1
29 personality disorder 10.1
30 secretory meningioma 10.1
31 mammographic density 10.0 CYP17A1 CYP19A1
32 female reproductive system disease 10.0 CYP19A1 ESR2
33 gonadal disease 10.0 AR CYP19A1
34 mycetoma 10.0 CYP17A1 CYP19A1
35 antley-bixler syndrome 10.0 CYP17A1 CYP19A1
36 leydig cell tumor 10.0 CYP17A1 CYP19A1
37 cryptorchidism, unilateral or bilateral 10.0 AR CYP19A1
38 thrombophilia due to thrombin defect 10.0
39 prostate cancer, hereditary, 8 10.0
40 prostate cancer, hereditary, 6 10.0
41 thrombosis 10.0
42 hypogonadotropic hypogonadism 10.0
43 ovarian disease 10.0
44 fetishism 10.0
45 urethritis 10.0
46 breast fibroadenoma 10.0
47 syphilis 10.0
48 homocystinuria 10.0
49 lipoid congenital adrenal hyperplasia 9.9 CYP17A1 CYP19A1
50 alopecia, androgenetic, 1 9.9 AR CYP19A1 SRD5A2

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to Transsexualism

Symptoms & Phenotypes for Transsexualism

MGI Mouse Phenotypes related to Transsexualism:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.88 AR CYP19A1 ESR2 RFX6 RPGRIP1L SRD5A2
2 adipose tissue MP:0005375 9.85 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L
3 growth/size/body region MP:0005378 9.85 AR CYP17A1 CYP19A1 ESR2 RFX6 RPGRIP1L
4 digestive/alimentary MP:0005381 9.83 AR CYP19A1 ESR2 RFX6 RPGRIP1L
5 homeostasis/metabolism MP:0005376 9.8 AR CYP17A1 CYP19A1 ESR2 RFX6 RPGRIP1L
6 liver/biliary system MP:0005370 9.56 AR CYP19A1 ESR2 RPGRIP1L
7 renal/urinary system MP:0005367 9.46 AR CYP19A1 ESR2 RPGRIP1L
8 reproductive system MP:0005389 9.43 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L SRD5A2
9 skeleton MP:0005390 9.02 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L

Drugs & Therapeutics for Transsexualism

Drugs for Transsexualism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testolactone Approved, Investigational Phase 4 968-93-4 13769
2 Lynestrenol Approved, Investigational Phase 4 52-76-6
3
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3 5949-44-0
4
Testosterone enanthate Approved Phase 4,Phase 3 315-37-7 9416
5
Methyltestosterone Approved Phase 4,Phase 3 58-18-4 6010
6
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
7
Testosterone Approved, Experimental, Investigational Phase 4,Phase 3 58-22-0, 481-30-1 10204 6013
8
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
9
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
10 5-alpha Reductase Inhibitors Phase 4,Phase 3
11 Androgen Antagonists Phase 4
12 Hormone Antagonists Phase 4,Phase 3
13 Steroid Synthesis Inhibitors Phase 4,Phase 3
14 Testosterone 17 beta-cypionate Phase 4,Phase 3
15 Estradiol 3-benzoate Phase 4,Phase 3
16 Hormones Phase 4,Phase 3
17 Neurotransmitter Agents Phase 4
18 Contraceptives, Oral Phase 4
19 Serotonin Agents Phase 4
20 Contraceptive Agents Phase 4
21 Contraceptive Agents, Male Phase 4
22 Estradiol 17 beta-cypionate Phase 4,Phase 3
23
Cyproterone Phase 4 2098-66-0 5284537
24 Estrogens Phase 4,Phase 3
25 Serotonin Receptor Agonists Phase 4
26 Androgens Phase 4,Phase 3
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
28 Antineoplastic Agents, Hormonal Phase 4,Phase 3
29
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
30
Dutasteride Approved, Investigational Phase 3 164656-23-9 6918296 152945
31
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
32
Dihydrotestosterone Illicit, Investigational Phase 3 521-18-6 10635
33 Estrogen Antagonists Phase 3
34 Anabolic Agents Phase 3
35 Aromatase Inhibitors Phase 3
36 Estrogen Receptor Antagonists Phase 3
37
Hydrocortisone Approved, Vet_approved 50-23-7 5754
38
Hydrocortisone acetate Approved, Vet_approved 50-03-3
39
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
40 Mitoguazone Investigational 459-86-9
41 Calciferol
42 Vitamins
43 Hydrocortisone 17-butyrate 21-propionate
44 Hydrocortisone hemisuccinate

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Sex Steroids and the Serotonin Transporter Completed NCT01065220 Phase 4 Testolactone undecanoate;Lynestrenol;Cyproterone Acetate;Estradiol;5-alpha reductase inhibitor
2 Testosterone and Its Metabolites in GID Completed NCT00146146 Phase 3 testosterone undecanoate alone;testosterone undecanoate plus letrozole;testosterone undecanoate plus dutasteride
3 A Common Polymorphism of the SRD5A2 Gene is Not Associated With Male-to-Female and Female-to-Male Transsexualism Completed NCT00435513
4 First Australian National Trans Mental Health Study Completed NCT02119377
5 Decrease of Libido of Post-Operative Male-Female Transsexuals and a Healthy Female Control Group Completed NCT00135148
6 GEnder Dysphoria Treatment in Sweden Recruiting NCT02518009
7 TransCare - Genital Surgery for Trans Women in Centralized vs. Decentralized Healthcare Settings Recruiting NCT03872648
8 A European Network for the Investigation of Gender Incongruence Recruiting NCT01072825
9 Sexuality in Transmen During Hormone and Operative Treatment Recruiting NCT03637920
10 Observational Study on Metabolism and Psychopathology in Transsexual Patients Active, not recruiting NCT02185274
11 Transgender Cohort Study of Gender Affirmation and HIV-related Health Enrolling by invitation NCT03595956
12 Use of an External Erectile Device in Transgender Man Following Phalloplasty Not yet recruiting NCT03823014 Not Applicable

Search NIH Clinical Center for Transsexualism

Cochrane evidence based reviews: transsexualism

Genetic Tests for Transsexualism

Anatomical Context for Transsexualism

MalaCards organs/tissues related to Transsexualism:

42
Brain, Testes, Ovary, Pituitary, Adipocyte, T Cells

Publications for Transsexualism

Articles related to Transsexualism:

(show top 50) (show all 287)
# Title Authors Year
1
Transsexualism: A Different Viewpoint to Brain Changes. ( 29739126 )
2018
2
Prevalence, Incidence, and Sex Ratio of Transsexualism in the Autonomous Region of Madrid (Spain) According to Healthcare Demand. ( 28224311 )
2017
3
BIRTH ORDER AND ANDROPHILIC MALE-TO-FEMALE TRANSSEXUALISM IN BRAZIL. ( 27817755 )
2017
4
Clinical Management of Gender in Egypt: Intersexuality and Transsexualism. ( 27649696 )
2017
5
Clinical dimensions of a 'biological concept': transsexualism and the interplay between etiological theory and clinical therapy. ( 27578416 )
2016
6
A Review of the Status of Brain Structure Research in Transsexualism. ( 27255307 )
2016
7
The transsexual brain--A review of findings on the neural basis of transsexualism. ( 26429593 )
2015
8
Sociodemographic Study of Danish Individuals Diagnosed with Transsexualism. ( 26185676 )
2015
9
Systematic review and meta-analysis of prevalence studies in transsexualism. ( 26021270 )
2015
10
Association study of ERβ, AR, and CYP19A1 genes and MtF transsexualism. ( 25124466 )
2014
11
Challenges in the diagnosis and treatment of transsexualism in contemporary China. ( 25114481 )
2014
12
The (CA)n polymorphism of ERβ gene is associated with FtM transsexualism. ( 24274329 )
2014
13
Robotic single site hysterectomy with bilateral salpingo-oophorectomy in female to male transsexualism. ( 24134805 )
2014
14
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. ( 23857518 )
2014
15
[Psycho-medical care of transsexuals in Spain in the era of depathologization of transsexualism as a mental disorder. An overall review]. ( 23916699 )
2013
16
On the quest for a biomechanism of transsexualism: is there a role for BDNF? ( 24070909 )
2013
17
Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. ( 23809495 )
2013
18
Hysterectomy and bilateral adnexectomy by laparoscopic single port access for female to male transsexualism. ( 23433319 )
2013
19
More evidence that societal individualism predicts prevalence of nonhomosexual orientation in male-to-female transsexualism. ( 23377823 )
2013
20
Increased Cortical Thickness in Male-to-Female Transsexualism. ( 23724358 )
2012
21
First Transsexualism European Meeting : Psychological, Medical and Surgical management in gender identity disorder. An international highlight 17 (th) -18 (th) May 2012 Dental School, Turin, Italy. ( 27517686 )
2012
22
New MRI studies support the Blanchard typology of male-to-female transsexualism. ( 21739338 )
2011
23
Karyotyping, is it worthwhile in transsexualism? ( 21114769 )
2011
24
Glottoplasty for male-to-female transsexualism: voice results. ( 20171832 )
2011
25
Transsexualism ("gender identity disorder") - a CNS-limited form of intersexuality? ( 21691959 )
2011
26
Distinctive features of female-to-male transsexualism and prevalence of gender identity disorder in Japan. ( 21477021 )
2011
27
Relationship challenges and relationship maintenance activities following disclosure of transsexualism. ( 21078006 )
2010
28
Transsexualism--diagnostic and therapeutic aspects. ( 20806188 )
2010
29
Transsexualism. ( 20642030 )
2010
30
Male-to-female transsexualism: technique, results and 3-year follow-up in 50 patients. ( 20389165 )
2010
31
Transsexualism - attitudes in general practice. ( 20372674 )
2010
32
Societal individualism predicts prevalence of nonhomosexual orientation in male-to-female transsexualism. ( 19067152 )
2010
33
Gender reassignment surgery in male-to-female transsexualism: A retrospective 3-month follow-up study with anatomical remarks. ( 19473463 )
2009
34
Regional gray matter variation in male-to-female transsexualism. ( 19341803 )
2009
35
Transsexualism in Australia: a further statistic. ( 19227577 )
2009
36
Quality of life 15 years after sex reassignment surgery for transsexualism. ( 18990387 )
2009
37
Androgen receptor repeat length polymorphism associated with male-to-female transsexualism. ( 18962445 )
2009
38
Transsexualism in Serbia: a twenty-year follow-up study. ( 18331254 )
2009
39
Prevalence of transsexualism among New Zealand passport holders. ( 18777233 )
2008
40
Shame and narcissistic rage in autogynephilic transsexualism. ( 18431633 )
2008
41
Long-term outcome of forearm flee-flap phalloplasty in the treatment of transsexualism. ( 18190640 )
2008
42
Body image and transsexualism. ( 18033979 )
2008
43
A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism. ( 17765230 )
2008
44
Twins and transsexualism: an update and a preview; research reviews: conjoined twins, angiographic lesions, single versus double embryo transfer; headlines: school placement legislation, Junior Taekwondo Olympics, prosthetic ears, murder victim. ( 18179403 )
2007
45
Psychotherapy and transsexualism. ( 18076425 )
2007
46
A common polymorphism of the SRD5A2 gene and transsexualism. ( 18000232 )
2007
47
Becoming what we love: autogynephilic transsexualism conceptualized as an expression of romantic love. ( 17951885 )
2007
48
Monozygotic twins concordant for female-to-male transsexualism: a case report. ( 17235675 )
2007
49
Prevalence and demography of transsexualism in Belgium. ( 17188846 )
2007
50
Two monozygotic twin pairs discordant for female-to-male transsexualism. ( 16802182 )
2006

Variations for Transsexualism

Expression for Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for Transsexualism

GO Terms for Transsexualism

Biological processes related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.63 AR ESR2 SRD5A2
2 androgen metabolic process GO:0008209 9.4 CYP19A1 SRD5A2
3 androgen biosynthetic process GO:0006702 9.37 CYP17A1 SRD5A2
4 prostate gland growth GO:0060736 9.32 AR CYP19A1
5 testosterone biosynthetic process GO:0061370 9.16 CYP19A1 SRD5A2
6 sterol metabolic process GO:0016125 9.13 CYP19A1
7 steroid biosynthetic process GO:0006694 9.13 CYP17A1 CYP19A1 SRD5A2
8 female genitalia development GO:0030540 8.96 CYP19A1
9 sex differentiation GO:0007548 8.8 AR CYP17A1 SRD5A2

Molecular functions related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.54 AR ESR2 RFX6
2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.32 CYP17A1 CYP19A1
3 steroid hormone receptor activity GO:0003707 9.26 AR ESR2
4 nuclear receptor activity GO:0004879 9.16 AR ESR2
5 oxygen binding GO:0019825 8.96 CYP17A1 CYP19A1
6 steroid binding GO:0005496 8.62 AR ESR2

Sources for Transsexualism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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