MCID: TRN007
MIFTS: 43

Transsexualism

Categories: Mental diseases

Aliases & Classifications for Transsexualism

MalaCards integrated aliases for Transsexualism:

Name: Transsexualism 12 44 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10919
ICD9CM 35 302.50
MeSH 44 D014189
ICD10 33 F64.0
UMLS 73 C0040630

Summaries for Transsexualism

Disease Ontology : 12 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards based summary : Transsexualism is related to hypospadias and polycystic ovary syndrome. An important gene associated with Transsexualism is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are TGF-beta Signaling Pathways and Nuclear Receptor transcription pathway. The drugs Estradiol and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and adipocyte, and related phenotypes are adipose tissue and growth/size/body region

Related Diseases for Transsexualism

Diseases related to Transsexualism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 hypospadias 29.8 CYP17A1 AR
2 polycystic ovary syndrome 29.8 CYP21A2 CYP19A1 CYP17A1
3 gender identity disorder 29.6 RPGRIP1L RFX6 ESR2 CYP19A1 AR
4 hyperandrogenism 29.5 CYP21A2 CYP19A1 CYP17A1
5 osteoporosis 29.5 ESR2 CYP19A1 AR
6 prostate cancer 29.2 ESR2 CYP19A1 CYP17A1 AR
7 transsexuality 12.2
8 transvestism 10.4
9 postmenopausal atrophic vaginitis 10.2 ESR2 AR
10 vaginitis 10.2 ESR2 AR
11 testicular germ cell cancer 10.1 ESR2 AR
12 germ cell cancer 10.1 ESR2 AR
13 androgen insensitivity, partial 10.1 CYP19A1 AR
14 progesterone-receptor positive breast cancer 10.1 ESR2 CYP19A1
15 estrogen excess 10.1 ESR2 CYP19A1
16 complete androgen insensitivity syndrome 10.1 CYP19A1 AR
17 androgenic alopecia 10.1 CYP19A1 AR
18 endometriosis of ovary 10.1 ESR2 CYP19A1
19 prostatic hypertrophy 10.1 CYP19A1 AR
20 endometriosis 10.1 ESR2 CYP19A1
21 pseudovaginal perineoscrotal hypospadias 10.1 CYP17A1 AR
22 schizophrenia 10.1
23 gynecomastia 10.1 CYP19A1 AR
24 mammographic density 10.1 CYP19A1 CYP17A1
25 primary pigmented nodular adrenocortical disease 10.1 ESR2 CYP19A1
26 ductal carcinoma in situ 10.1 CYP19A1 AR
27 mycetoma 10.1 CYP19A1 CYP17A1
28 luteoma 10.0 CYP21A2 CYP19A1
29 gonadal disease 10.0 CYP19A1 AR
30 female reproductive system disease 10.0 ESR2 CYP19A1
31 cryptorchidism, unilateral or bilateral 10.0 CYP19A1 AR
32 cytochrome p450 oxidoreductase deficiency 10.0 CYP21A2 CYP17A1
33 testicular leydig cell tumor 10.0 CYP21A2 CYP17A1
34 precocious puberty 10.0 CYP21A2 CYP19A1
35 steroid inherited metabolic disorder 10.0 CYP21A2 CYP17A1
36 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.0 CYP21A2 CYP17A1
37 adrenal cortical adenoma 10.0 CYP21A2 CYP17A1
38 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 10.0 CYP21A2 CYP17A1
39 prostatic hyperplasia, benign 10.0 ESR2 CYP17A1 AR
40 leiomyoma 10.0 ESR2 CYP19A1
41 male reproductive organ cancer 10.0 ESR2 CYP17A1 AR
42 male reproductive system disease 10.0 ESR2 CYP17A1 AR
43 cortisone reductase deficiency 10.0 CYP21A2 CYP17A1
44 adrenal adenoma 10.0 CYP21A2 CYP17A1
45 pseudohermaphroditism 10.0 CYP19A1 CYP17A1 AR
46 adrenal carcinoma 9.9 CYP21A2 CYP17A1
47 prostate disease 9.9 CYP19A1 CYP17A1 AR
48 thrombophilia due to thrombin defect 9.9
49 thrombosis 9.9
50 hypogonadotropic hypogonadism 9.9

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to Transsexualism

Symptoms & Phenotypes for Transsexualism

MGI Mouse Phenotypes related to Transsexualism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.85 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L
2 growth/size/body region MP:0005378 9.85 AR CYP17A1 CYP19A1 ESR2 RFX6 RPGRIP1L
3 digestive/alimentary MP:0005381 9.83 AR CYP19A1 ESR2 RFX6 RPGRIP1L
4 endocrine/exocrine gland MP:0005379 9.8 AR CYP19A1 ESR2 RFX6 RPGRIP1L
5 homeostasis/metabolism MP:0005376 9.8 AR CYP17A1 CYP19A1 ESR2 RFX6 RPGRIP1L
6 liver/biliary system MP:0005370 9.56 AR CYP19A1 ESR2 RPGRIP1L
7 renal/urinary system MP:0005367 9.55 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L
8 reproductive system MP:0005389 9.35 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L
9 skeleton MP:0005390 9.02 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L

Drugs & Therapeutics for Transsexualism

Drugs for Transsexualism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
2 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3 979-32-8
3
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
4 Lynestrenol Approved, Investigational Phase 4 52-76-6
5
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3 5949-44-0
6
Methyltestosterone Approved Phase 4,Phase 3 58-18-4 6010
7
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
8
Testosterone Approved, Investigational Phase 4,Phase 3 58-22-0 6013
9
Testosterone enanthate Approved Phase 4,Phase 3 315-37-7 9416
10
Testolactone Approved, Investigational Phase 4 968-93-4 13769
11 Hormones Phase 4,Phase 3
12
Cyproterone Phase 4 2098-66-0 5284537
13 Serotonin Agents Phase 4
14 Antineoplastic Agents, Hormonal Phase 4,Phase 3
15 Estrogens Phase 4,Phase 3
16 Androgen Antagonists Phase 4
17 Androgens Phase 4,Phase 3
18 Steroid Synthesis Inhibitors Phase 4,Phase 3
19 Estradiol 3-benzoate Phase 4,Phase 3
20 Testosterone 17 beta-cypionate Phase 4,Phase 3
21 Contraceptives, Oral Phase 4
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
23 Hormone Antagonists Phase 4,Phase 3
24 Estradiol 17 beta-cypionate Phase 4,Phase 3
25 5-alpha Reductase Inhibitors Phase 4,Phase 3
26 Neurotransmitter Agents Phase 4
27 Contraceptive Agents, Male Phase 4
28 Contraceptive Agents Phase 4
29
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
30
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
31
Dutasteride Approved, Investigational Phase 3 164656-23-9 6918296 152945
32
Dihydrotestosterone Illicit, Investigational Phase 3 521-18-6 10635
33 Estrogen Antagonists Phase 3
34 Estrogen Receptor Antagonists Phase 3
35 Aromatase Inhibitors Phase 3
36 Anabolic Agents Phase 3
37
Hydrocortisone acetate Approved, Vet_approved 50-03-3
38
Hydrocortisone Approved, Vet_approved 50-23-7 5754
39
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
40 Mitoguazone Investigational 459-86-9
41 Cortisol succinate
42 Hydrocortisone 17-butyrate 21-propionate
43 Vitamins
44 Calciferol

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sex Steroids and the Serotonin Transporter Completed NCT01065220 Phase 4 Testolactone undecanoate;Lynestrenol;Cyproterone Acetate;Estradiol;5-alpha reductase inhibitor
2 Testosterone and Its Metabolites in GID Completed NCT00146146 Phase 3 testosterone undecanoate alone;testosterone undecanoate plus letrozole;testosterone undecanoate plus dutasteride
3 A Common Polymorphism of the SRD5A2 Gene is Not Associated With Male-to-Female and Female-to-Male Transsexualism Completed NCT00435513
4 First Australian National Trans Mental Health Study Completed NCT02119377
5 Decrease of Libido of Post-Operative Male-Female Transsexuals and a Healthy Female Control Group Completed NCT00135148
6 Observational Study on Metabolism and Psychopathology in Transsexual Patients Recruiting NCT02185274
7 GEnder Dysphoria Treatment in Sweden Recruiting NCT02518009
8 A European Network for the Investigation of Gender Incongruence Recruiting NCT01072825
9 Sexuality in Transmen During Hormone and Operative Treatment Recruiting NCT03637920
10 Transgender Cohort Study of Gender Affirmation and HIV-related Health Not yet recruiting NCT03595956

Search NIH Clinical Center for Transsexualism

Cochrane evidence based reviews: transsexualism

Genetic Tests for Transsexualism

Anatomical Context for Transsexualism

MalaCards organs/tissues related to Transsexualism:

41
Brain, Testes, Adipocyte, Ovary, Pituitary, Prostate

Publications for Transsexualism

Articles related to Transsexualism:

(show top 50) (show all 288)
# Title Authors Year
1
Transsexualism: A Different Viewpoint to Brain Changes. ( 29739126 )
2018
2
Prevalence, Incidence, and Sex Ratio of Transsexualism in the Autonomous Region of Madrid (Spain) According to Healthcare Demand. ( 28224311 )
2017
3
BIRTH ORDER AND ANDROPHILIC MALE-TO-FEMALE TRANSSEXUALISM IN BRAZIL. ( 27817755 )
2016
4
Clinical Management of Gender in Egypt: Intersexuality and Transsexualism. ( 27649696 )
2016
5
Clinical dimensions of a 'biological concept': transsexualism and the interplay between etiological theory and clinical therapy. ( 27578416 )
2016
6
A Review of the Status of Brain Structure Research in Transsexualism. ( 27255307 )
2016
7
Sociodemographic Study of Danish Individuals Diagnosed with Transsexualism. ( 26185676 )
2015
8
The transsexual brain - A review of findings on the neural basis of transsexualism. ( 26429593 )
2015
9
Systematic review and meta-analysis of prevalence studies in transsexualism. ( 26021270 )
2015
10
Robotic single site hysterectomy with bilateral salpingo-oophorectomy in female to male transsexualism. ( 24134805 )
2014
11
Association Study of ERI^, AR, and CYP19A1 Genes and MtF Transsexualism. ( 25124466 )
2014
12
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. ( 23857518 )
2014
13
Challenges in the diagnosis and treatment of transsexualism in contemporary China. ( 25114481 )
2014
14
The (CA)n Polymorphism of ERI^ Gene is Associated with FtM Transsexualism. ( 24274329 )
2013
15
The "Auto" (Self) in Autogynephilic Transsexualism Men Trapped in Men's Bodies: Narratives of Autogynephilic Transsexualism. By Anne A. Lawrence. New York, NY: Springer, 2013, 242 pages. Cloth, $129.00. ( 24171550 )
2013
16
On the quest for a biomechanism of transsexualism: is there a role for BDNF? ( 24070909 )
2013
17
Hysterectomy and bilateral adnexectomy by laparoscopic single port access for female to male transsexualism. ( 23433319 )
2013
18
Psycho-medical care of transsexuals in Spain in the era of depathologization of transsexualism as a mental disorder. An overall review. ( 23916699 )
2013
19
Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. ( 23809495 )
2013
20
More evidence that societal individualism predicts prevalence of nonhomosexual orientation in male-to-female transsexualism. ( 23377823 )
2013
21
First Transsexualism European Meeting : Psychological, Medical and Surgical management in gender identity disorder. An international highlight 17 (th) -18 (th) May 2012 Dental School, Turin, Italy. ( 27517686 )
2012
22
Increased Cortical Thickness in Male-to-Female Transsexualism. ( 23724358 )
2012
23
Transsexualism ("gender identity disorder") - a CNS-limited form of intersexuality? ( 21691959 )
2011
24
Karyotyping, is it worthwhile in transsexualism? ( 21114769 )
2011
25
New MRI studies support the Blanchard typology of male-to-female transsexualism. ( 21739338 )
2011
26
Distinctive features of female-to-male transsexualism and prevalence of gender identity disorder in Japan. ( 21477021 )
2011
27
Glottoplasty for male-to-female transsexualism: voice results. ( 20171832 )
2011
28
Relationship challenges and relationship maintenance activities following disclosure of transsexualism. ( 21078006 )
2010
29
Transsexualism--diagnostic and therapeutic aspects. ( 20806188 )
2010
30
Transsexualism. ( 20642030 )
2010
31
Male-to-female transsexualism: technique, results and 3-year follow-up in 50 patients. ( 20389165 )
2010
32
Transsexualism - attitudes in general practice. ( 20372674 )
2010
33
Societal individualism predicts prevalence of nonhomosexual orientation in male-to-female transsexualism. ( 19067152 )
2010
34
Transsexualism in Serbia: a twenty-year follow-up study. ( 18331254 )
2009
35
Gender reassignment surgery in male-to-female transsexualism: A retrospective 3-month follow-up study with anatomical remarks. ( 19473463 )
2009
36
Transsexualism in Australia: a further statistic. ( 19227577 )
2009
37
Androgen receptor repeat length polymorphism associated with male-to-female transsexualism. ( 18962445 )
2009
38
Quality of life 15 years after sex reassignment surgery for transsexualism. ( 18990387 )
2009
39
Regional gray matter variation in male-to-female transsexualism. ( 19341803 )
2009
40
Shame and narcissistic rage in autogynephilic transsexualism. ( 18431633 )
2008
41
Long-term outcome of forearm flee-flap phalloplasty in the treatment of transsexualism. ( 18190640 )
2008
42
Body image and transsexualism. ( 18033979 )
2008
43
Prevalence of transsexualism among New Zealand passport holders. ( 18777233 )
2008
44
A polymorphism of the CYP17 gene related to sex steroid metabolism is associated with female-to-male but not male-to-female transsexualism. ( 17765230 )
2008
45
Becoming what we love: autogynephilic transsexualism conceptualized as an expression of romantic love. ( 17951885 )
2007
46
Psychotherapy and transsexualism. ( 18076425 )
2007
47
A common polymorphism of the SRD5A2 gene and transsexualism. ( 18000232 )
2007
48
Twins and transsexualism: an update and a preview; research reviews: conjoined twins, angiographic lesions, single versus double embryo transfer; headlines: school placement legislation, Junior Taekwondo Olympics, prosthetic ears, murder victim. ( 18179403 )
2007
49
Prevalence and demography of transsexualism in Belgium. ( 17188846 )
2007
50
Monozygotic twins concordant for female-to-male transsexualism: a case report. ( 17235675 )
2007

Variations for Transsexualism

Expression for Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for Transsexualism

GO Terms for Transsexualism

Biological processes related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sex differentiation GO:0007548 9.32 AR CYP17A1
2 glucocorticoid biosynthetic process GO:0006704 9.26 CYP17A1 CYP21A2
3 prostate gland growth GO:0060736 9.16 AR CYP19A1
4 steroid biosynthetic process GO:0006694 9.13 CYP17A1 CYP19A1 CYP21A2
5 sterol metabolic process GO:0016125 8.8 CYP17A1 CYP19A1 CYP21A2

Molecular functions related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.65 AR ESR2 RFX6
2 lipid binding GO:0008289 9.58 AR CYP21A2 ESR2
3 steroid hormone receptor activity GO:0003707 9.46 AR ESR2
4 nuclear receptor activity GO:0004879 9.43 AR ESR2
5 heme binding GO:0020037 9.43 CYP17A1 CYP19A1 CYP21A2
6 oxygen binding GO:0019825 9.37 CYP17A1 CYP19A1
7 iron ion binding GO:0005506 9.33 CYP17A1 CYP19A1 CYP21A2
8 steroid hydroxylase activity GO:0008395 9.32 CYP19A1 CYP21A2
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP17A1 CYP19A1 CYP21A2
10 steroid binding GO:0005496 8.8 AR CYP21A2 ESR2

Sources for Transsexualism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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