Aliases & Classifications for Transsexualism

MalaCards integrated aliases for Transsexualism:

Name: Transsexualism 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10919
ICD9CM 35 302.50
SNOMED-CT 68 191782007
ICD10 33 F64.0
UMLS 73 C0040630

Summaries for Transsexualism

Disease Ontology : 12 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards based summary : Transsexualism is related to vaginitis and hyperandrogenism. An important gene associated with Transsexualism is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are TGF-beta Signaling Pathways and Nuclear Receptor transcription pathway. The drugs Cyproterone Acetate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and brain, and related phenotypes are adipose tissue and growth/size/body region

Related Diseases for Transsexualism

Diseases related to Transsexualism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 vaginitis 30.1 AR ESR2
2 hyperandrogenism 29.0 CYP17A1 CYP19A1 CYP21A2
3 polycystic ovary syndrome 29.0 CYP17A1 CYP19A1 CYP21A2
4 osteoporosis 28.9 AR CYP19A1 ESR2
5 hypospadias 28.8 AR CYP17A1
6 prostate cancer 27.8 AR CYP17A1 CYP19A1 ESR2
7 gender identity disorder 27.7 AR CYP19A1 ESR2 RFX6 RPGRIP1L
8 transsexuality 12.2
9 postmenopausal atrophic vaginitis 10.5 AR ESR2
10 testicular germ cell cancer 10.5 AR ESR2
11 androgen insensitivity, partial 10.4 AR CYP19A1
12 progesterone-receptor positive breast cancer 10.4 CYP19A1 ESR2
13 prostatic hyperplasia, benign 10.4 AR CYP19A1
14 androgenic alopecia 10.4 AR CYP19A1
15 estrogen excess 10.4 CYP19A1 ESR2
16 complete androgen insensitivity syndrome 10.4 AR CYP19A1
17 penis agenesis 10.3 AR CYP17A1
18 endometriosis of ovary 10.3 CYP19A1 ESR2
19 prostatic hypertrophy 10.3 AR CYP19A1
20 gynecomastia 10.3 AR CYP19A1
21 mammographic density 10.2 CYP17A1 CYP19A1
22 transvestism 10.2
23 ductal carcinoma in situ 10.2 AR CYP19A1
24 endocrine gland cancer 10.2 AR CYP19A1
25 mycetoma 10.2 CYP17A1 CYP19A1
26 luteoma 10.1 CYP19A1 CYP21A2
27 endometriosis 10.1 CYP19A1 ESR2
28 stuttering 10.1 CYP17A1 CYP19A1
29 cryptorchidism, unilateral or bilateral 10.1 AR CYP19A1
30 cytochrome p450 oxidoreductase deficiency 10.1 CYP17A1 CYP21A2
31 testicular leydig cell tumor 10.0 CYP17A1 CYP21A2
32 steroid inherited metabolic disorder 10.0 CYP17A1 CYP21A2
33 precocious puberty 10.0 CYP19A1 CYP21A2
34 leiomyoma 10.0 CYP19A1 ESR2
35 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 10.0 CYP17A1 CYP21A2
36 reproductive system disease 10.0 AR CYP19A1 ESR2
37 schizophrenia 10.0
38 prostatitis 10.0
39 adrenal cortical adenoma 9.9 CYP17A1 CYP21A2
40 adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete 9.9 CYP17A1 CYP21A2
41 male reproductive organ cancer 9.9 AR CYP17A1 ESR2
42 adrenal adenoma 9.9 CYP17A1 CYP21A2
43 adrenal carcinoma 9.9 CYP17A1 CYP21A2
44 pseudohermaphroditism 9.9 AR CYP17A1 CYP19A1
45 female reproductive system disease 9.8 CYP17A1 CYP19A1 ESR2
46 thrombophilia due to thrombin defect 9.8
47 thrombosis 9.8
48 hypogonadotropic hypogonadism 9.8
49 ovarian disease 9.8
50 fetishism 9.8

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to Transsexualism

Symptoms & Phenotypes for Transsexualism

MGI Mouse Phenotypes related to Transsexualism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.85 CYP19A1 ESR2 AR RPGRIP1L CYP17A1
2 growth/size/body region MP:0005378 9.85 CYP17A1 RPGRIP1L CYP19A1 ESR2 AR RFX6
3 digestive/alimentary MP:0005381 9.83 RPGRIP1L CYP19A1 ESR2 AR RFX6
4 endocrine/exocrine gland MP:0005379 9.8 RPGRIP1L CYP19A1 ESR2 AR RFX6
5 homeostasis/metabolism MP:0005376 9.8 CYP17A1 RPGRIP1L CYP19A1 ESR2 RFX6 AR
6 liver/biliary system MP:0005370 9.56 RPGRIP1L CYP19A1 ESR2 AR
7 renal/urinary system MP:0005367 9.55 RPGRIP1L CYP17A1 CYP19A1 ESR2 AR
8 reproductive system MP:0005389 9.35 CYP17A1 RPGRIP1L CYP19A1 ESR2 AR
9 skeleton MP:0005390 9.02 CYP17A1 RPGRIP1L CYP19A1 ESR2 AR

Drugs & Therapeutics for Transsexualism

Drugs for Transsexualism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
3 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3 979-32-8
4 Lynestrenol Approved, Investigational Phase 4 52-76-6
5
Methyltestosterone Approved Phase 4,Phase 3 58-18-4 6010
6
Polyestradiol phosphate Approved Phase 4,Phase 3 28014-46-2
7
Testolactone Approved, Investigational Phase 4 968-93-4 13769
8
Testosterone Approved, Investigational Phase 4,Phase 3 58-22-0 6013
9
Testosterone enanthate Approved Phase 4,Phase 3 315-37-7 9416
10
Testosterone undecanoate Approved, Investigational Phase 4,Phase 3 5949-44-0
11 5-alpha Reductase Inhibitors Phase 4,Phase 3
12 Androgen Antagonists Phase 4
13 Androgens Phase 4,Phase 3
14 Antineoplastic Agents, Hormonal Phase 4,Phase 3
15 Contraceptive Agents Phase 4
16 Contraceptive Agents, Male Phase 4
17 Contraceptives, Oral Phase 4
18
Cyproterone Phase 4 2098-66-0 5284537
19 Estradiol 17 beta-cypionate Phase 4,Phase 3
20 Estradiol 3-benzoate Phase 4,Phase 3
21 Estrogens Phase 4,Phase 3
22 Hormone Antagonists Phase 4,Phase 3
23 Hormones Phase 4,Phase 3
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
25 Neurotransmitter Agents Phase 4
26 Serotonin Agents Phase 4
27 Steroid Synthesis Inhibitors Phase 4,Phase 3
28 Testosterone 17 beta-cypionate Phase 4,Phase 3
29
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
30
Dutasteride Approved, Investigational Phase 3 164656-23-9 152945 6918296
31
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
32
Dihydrotestosterone Illicit, Investigational Phase 3 521-18-6 10635
33 Anabolic Agents Phase 3
34 Aromatase Inhibitors Phase 3
35 Estrogen Antagonists Phase 3
36
Hydrocortisone Approved, Vet_approved 50-23-7 5754
37
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
38 Cortisol succinate
39 Hydrocortisone 17-butyrate 21-propionate
40 Hydrocortisone acetate
41 Vitamins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sex Steroids and the Serotonin Transporter Completed NCT01065220 Phase 4 Testolactone undecanoate;Lynestrenol;Cyproterone Acetate;Estradiol;5-alpha reductase inhibitor
2 Testosterone and Its Metabolites in GID Completed NCT00146146 Phase 3 testosterone undecanoate alone;testosterone undecanoate plus letrozole;testosterone undecanoate plus dutasteride
3 A Common Polymorphism of the SRD5A2 Gene is Not Associated With Male-to-Female and Female-to-Male Transsexualism Completed NCT00435513
4 First Australian National Trans Mental Health Study Completed NCT02119377
5 Decrease of Libido of Post-Operative Male-Female Transsexuals and a Healthy Female Control Group Completed NCT00135148
6 Observational Study on Metabolism and Psychopathology in Transsexual Patients Recruiting NCT02185274
7 GEnder Dysphoria Treatment in Sweden Recruiting NCT02518009
8 A European Network for the Investigation of Gender Incongruence Recruiting NCT01072825

Search NIH Clinical Center for Transsexualism

Genetic Tests for Transsexualism

Anatomical Context for Transsexualism

MalaCards organs/tissues related to Transsexualism:

41
Bone, Testes, Brain, Prostate, Ovary, Breast, Pituitary

Publications for Transsexualism

Articles related to Transsexualism:

(show top 50) (show all 361)
# Title Authors Year
1
Transsexualism: A Different Viewpoint to Brain Changes. ( 29739126 )
2018
2
Prevalence, Incidence, and Sex Ratio of Transsexualism in the Autonomous Region of Madrid (Spain) According to Healthcare Demand. ( 28224311 )
2017
3
The Pattern of Sexual Interest of Female-to-Male Transsexual Persons With Gender Identity Disorder Does Not Resemble That of Biological Men: An Eye-Tracking Study. ( 28823313 )
2017
4
BIRTH ORDER AND ANDROPHILIC MALE-TO-FEMALE TRANSSEXUALISM IN BRAZIL. ( 27817755 )
2016
5
Clinical Management of Gender in Egypt: Intersexuality and Transsexualism. ( 27649696 )
2016
6
Clinical dimensions of a 'biological concept': transsexualism and the interplay between etiological theory and clinical therapy. ( 27578416 )
2016
7
Reduced serum concentrations of brain-derived neurotrophic factor (BDNF) in transsexual Brazilian men. ( 27473941 )
2016
8
A Review of the Status of Brain Structure Research in Transsexualism. ( 27255307 )
2016
9
Sociodemographic Study of Danish Individuals Diagnosed with Transsexualism. ( 26185676 )
2015
10
The transsexual brain - A review of findings on the neural basis of transsexualism. ( 26429593 )
2015
11
"Living in a Shell of Something I'm Not": Transsexuality, Medical Ethics, and the Judeo-Christian Culture. ( 26156704 )
2015
12
Systematic review and meta-analysis of prevalence studies in transsexualism. ( 26021270 )
2015
13
AntimA1llerian hormone levels decrease in female-to-male transsexuals using testosterone as cross-sex therapy. ( 25772768 )
2015
14
Robotic single site hysterectomy with bilateral salpingo-oophorectomy in female to male transsexualism. ( 24134805 )
2014
15
Diagnosis of prolactinoma in two male-to-female transsexual subjects following high-dose cross-sex hormone therapy. ( 25059808 )
2014
16
The invisibility of gender diversity: understanding transgender and transsexuality in nursing literature. ( 24387331 )
2014
17
Association Study of ERI^, AR, and CYP19A1 Genes and MtF Transsexualism. ( 25124466 )
2014
18
Treatment of anorexia nervosa in the context of transsexuality: A case report. ( 24323528 )
2014
19
Bilateral Non-arteritic Ischemic Optic Neuropathy in a Transsexual Woman Using Excessive Estrogen Dosage. ( 24057212 )
2014
20
Discordant transsexualism in male monozygotic twins: neuroanatomical and psychological differences. ( 23857518 )
2014
21
Challenges in the diagnosis and treatment of transsexualism in contemporary China. ( 25114481 )
2014
22
Prevalence of hyperandrogenism and polycystic ovary syndrome in female to male transsexuals. ( 24680383 )
2014
23
Hypogonadism in a male-to-female transsexual with super obesity. ( 22783836 )
2013
24
The (CA)n Polymorphism of ERI^ Gene is Associated with FtM Transsexualism. ( 24274329 )
2013
25
The "Auto" (Self) in Autogynephilic Transsexualism Men Trapped in Men's Bodies: Narratives of Autogynephilic Transsexualism. By Anne A. Lawrence. New York, NY: Springer, 2013, 242 pages. Cloth, $129.00. ( 24171550 )
2013
26
Symptomatic meningioma induced by cross-sex hormone treatment in a male-to-female transsexual. ( 23022362 )
2013
27
[The social background of male to female transsexuals]. ( 23970400 )
2013
28
On the quest for a biomechanism of transsexualism: is there a role for BDNF? ( 24070909 )
2013
29
Hysterectomy and bilateral adnexectomy by laparoscopic single port access for female to male transsexualism. ( 23433319 )
2013
30
Psycho-medical care of transsexuals in Spain in the era of depathologization of transsexualism as a mental disorder. An overall review. ( 23916699 )
2013
31
HIV, hepatitis B/C and syphilis prevalence and risk behaviors among gay, transsexuals and men who have sex with men, Dominican Republic. ( 23970664 )
2013
32
Twenty years of endocrinologic treatment in transsexualism: analyzing the role of chromosomal analysis and hormonal profiling in the diagnostic work-up. ( 23809495 )
2013
33
More evidence that societal individualism predicts prevalence of nonhomosexual orientation in male-to-female transsexualism. ( 23377823 )
2013
34
Prostate cancer incidence in orchidectomised male-to-female transsexual persons treated with oestrogens. ( 24329588 )
2013
35
Development of systemic lupus erythematosus in a male-to-female transsexual: the role of sex hormones revisited. ( 23897544 )
2013
36
First Transsexualism European Meeting : Psychological, Medical and Surgical management in gender identity disorder. An international highlight 17 (th) -18 (th) May 2012 Dental School, Turin, Italy. ( 27517686 )
2012
37
Increased Cortical Thickness in Male-to-Female Transsexualism. ( 23724358 )
2012
38
Human papilloma virus genotype diversity of anal infection among trans (male to female transvestites, transsexuals or transgender) sex workers in Argentina. ( 21511521 )
2011
39
The health and well-being of prostate cancer patients and male-to-female transsexuals on androgen deprivation therapy: a qualitative study with comments on expectations and estrogen. ( 21218363 )
2011
40
Dysfunctional core beliefs, perceived parenting behavior and psychopathology in gender identity disorder: A comparison of male-to-female, female-to-male transsexual and nontranssexual control subjects. ( 21074005 )
2011
41
Transsexualism ("gender identity disorder") - a CNS-limited form of intersexuality? ( 21691959 )
2011
42
Karyotyping, is it worthwhile in transsexualism? ( 21114769 )
2011
43
New MRI studies support the Blanchard typology of male-to-female transsexualism. ( 21739338 )
2011
44
Distinctive features of female-to-male transsexualism and prevalence of gender identity disorder in Japan. ( 21477021 )
2011
45
Glottoplasty for male-to-female transsexualism: voice results. ( 20171832 )
2011
46
Relationship challenges and relationship maintenance activities following disclosure of transsexualism. ( 21078006 )
2010
47
Transsexualism--diagnostic and therapeutic aspects. ( 20806188 )
2010
48
Transsexualism. ( 20642030 )
2010
49
Incidence of thrombophilia and venous thrombosis in transsexuals under cross-sex hormone therapy. ( 19200981 )
2010
50
Contribution of androgen receptor sensitivity to the relation between testosterone and sexual desire: An exploration in male-to-female transsexuals. ( 19620824 )
2010

Variations for Transsexualism

Expression for Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for Transsexualism

GO Terms for Transsexualism

Biological processes related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.37 AR ESR2
2 sex differentiation GO:0007548 9.32 AR CYP17A1
3 glucocorticoid biosynthetic process GO:0006704 9.26 CYP17A1 CYP21A2
4 prostate gland growth GO:0060736 9.16 AR CYP19A1
5 steroid biosynthetic process GO:0006694 9.13 CYP17A1 CYP19A1 CYP21A2
6 sterol metabolic process GO:0016125 8.8 CYP17A1 CYP19A1 CYP21A2

Molecular functions related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.54 AR CYP21A2 ESR2
2 steroid hormone receptor activity GO:0003707 9.46 AR ESR2
3 oxygen binding GO:0019825 9.43 CYP17A1 CYP19A1
4 iron ion binding GO:0005506 9.43 CYP17A1 CYP19A1 CYP21A2
5 nuclear receptor activity GO:0004879 9.4 AR ESR2
6 heme binding GO:0020037 9.33 CYP17A1 CYP19A1 CYP21A2
7 steroid hydroxylase activity GO:0008395 9.32 CYP19A1 CYP21A2
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP17A1 CYP19A1 CYP21A2
9 steroid binding GO:0005496 8.8 AR CYP21A2 ESR2

Sources for Transsexualism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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