MCID: TRN007
MIFTS: 38

Transsexualism

Categories: Mental diseases

Aliases & Classifications for Transsexualism

MalaCards integrated aliases for Transsexualism:

Name: Transsexualism 12 15 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10919
ICD9CM 34 302.50
SNOMED-CT 67 191782007
ICD10 32 F64.0
UMLS 70 C0040630

Summaries for Transsexualism

Disease Ontology : 12 A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

MalaCards based summary : Transsexualism is related to transvestism and hermaphroditism. An important gene associated with Transsexualism is CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1), and among its related pathways/superpathways are Androstenedione and testosterone biosynthesis and metabolism p.1 and Metabolism of steroid hormones. The drugs Methyltestosterone and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include breast, ovary and bone, and related phenotypes are growth/size/body region and adipose tissue

Related Diseases for Transsexualism

Diseases related to Transsexualism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 transvestism 30.9 ESR2 CYP17A1
2 hermaphroditism 30.3 SRD5A2 AR
3 gender identity disorder 29.8 RPGRIP1L ESR2 CYP19A1 CYP17A1 AR
4 ovarian disease 29.2 ESR2 CYP19A1 CYP17A1 AR
5 lipoid congenital adrenal hyperplasia 29.2 CYP21A2 CYP19A1 CYP17A1
6 osteoporosis 29.2 ESR2 CYP19A1 CYP17A1 AR
7 hypospadias 29.1 SRD5A2 ESR2 CYP17A1 AR
8 polycystic ovary syndrome 29.1 CYP21A2 CYP19A1 CYP17A1 AR
9 infertility 29.0 ESR2 CYP21A2 CYP19A1 AR
10 pseudohermaphroditism 28.6 SRD5A2 CYP21A2 CYP19A1 CYP17A1 AR
11 gynecomastia 28.5 SRD5A2 ESR2 CYP21A2 CYP19A1 AR
12 transsexuality 10.3
13 personality disorder 10.2
14 vaginal adenoma 10.2 ESR2 CYP19A1
15 vaginal benign neoplasm 10.2 ESR2 CYP19A1
16 vaginitis 10.2 ESR2 AR
17 progesterone-receptor positive breast cancer 10.1 ESR2 CYP19A1
18 estrogen excess 10.1 ESR2 CYP19A1
19 ovarian endometrioid stromal sarcoma 10.1 CYP19A1 AR
20 androgen insensitivity, partial 10.1 CYP19A1 AR
21 endometriosis of ovary 10.1 ESR2 CYP19A1
22 ovarian cyst 10.1 ESR2 CYP19A1
23 premature ejaculation 10.1 CYP19A1 AR
24 complete androgen insensitivity syndrome 10.1 CYP19A1 AR
25 uterine benign neoplasm 10.1 ESR2 CYP19A1
26 bronchiectasis 3 10.1 CYP17A1 AR
27 reproductive organ benign neoplasm 10.1 ESR2 CYP19A1
28 hypogonadotropic hypogonadism 10.1
29 sertoli cell tumor 10.1 CYP19A1 AR
30 adenomyosis 10.1 ESR2 CYP19A1
31 testicular germ cell cancer 10.1 ESR2 AR
32 mammographic density 10.1 CYP19A1 CYP17A1
33 mycetoma 10.1 CYP19A1 CYP17A1
34 breast fibroadenoma 10.1 CYP19A1 AR
35 estrogen-receptor negative breast cancer 10.1 CYP19A1 AR
36 female breast cancer 10.1 CYP19A1 AR
37 prostatic hyperplasia, benign 10.0 SRD5A2 AR
38 avoidant personality disorder 10.0
39 47,xyy 10.0
40 premature ovarian failure 1 10.0 CYP19A1 CYP17A1
41 testicular germ cell tumor 10.0 CYP19A1 AR
42 sporadic breast cancer 10.0 ESR2 CYP19A1
43 primary pigmented nodular adrenocortical disease 10.0 ESR2 CYP19A1
44 smith-lemli-opitz syndrome 10.0 CYP19A1 CYP17A1
45 hypogonadism 10.0
46 psychotic disorder 10.0
47 severe combined immunodeficiency 10.0
48 homocystinuria 10.0
49 teeth hard tissue disease 10.0 ESR2 CYP19A1 AR
50 estrogen-receptor positive breast cancer 9.9 ESR2 CYP19A1 AR

Graphical network of the top 20 diseases related to Transsexualism:



Diseases related to Transsexualism

Symptoms & Phenotypes for Transsexualism

MGI Mouse Phenotypes related to Transsexualism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 AR CYP17A1 CYP19A1 CYP21A2 ESR2 RPGRIP1L
2 adipose tissue MP:0005375 9.83 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L
3 endocrine/exocrine gland MP:0005379 9.8 AR CYP19A1 ESR2 RPGRIP1L SRD5A2
4 hematopoietic system MP:0005397 9.73 AR CYP19A1 CYP21A2 ESR2 RPGRIP1L SRD5A2
5 immune system MP:0005387 9.63 AR CYP19A1 CYP21A2 ESR2 RPGRIP1L SRD5A2
6 hearing/vestibular/ear MP:0005377 9.62 CYP17A1 CYP19A1 ESR2 RPGRIP1L
7 integument MP:0010771 9.43 AR CYP19A1 CYP21A2 ESR2 RPGRIP1L SRD5A2
8 reproductive system MP:0005389 9.1 AR CYP17A1 CYP19A1 ESR2 RPGRIP1L SRD5A2

Drugs & Therapeutics for Transsexualism

Drugs for Transsexualism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4 58-18-4 6010
2
Polyestradiol phosphate Approved Phase 4 28014-46-2
3
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
4
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
5
Testosterone enanthate Approved Phase 4 315-37-7 9416
6
Testosterone Approved, Investigational Phase 4 58-22-0 6013
7
Lynestrenol Approved, Investigational Phase 4 52-76-6
8
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
9
Testolactone Approved, Investigational Phase 4 968-93-4 13769
10 5-alpha Reductase Inhibitors Phase 4
11 Estradiol 3-benzoate Phase 4
12 Estradiol 17 beta-cypionate Phase 4
13 Hormone Antagonists Phase 4
14 Estrogens Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Testosterone 17 beta-cypionate Phase 4
17 Androgens Phase 4
18 Contraceptive Agents Phase 4
19 Contraceptive Agents, Male Phase 4
20 Contraceptives, Oral Phase 4
21
Cyproterone Phase 4 2098-66-0 5284537
22 Androgen Antagonists Phase 4
23
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
24
Dutasteride Approved, Investigational Phase 3 164656-23-9 152945 6918296
25
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
26
Dihydrotestosterone Illicit, Investigational Phase 3 521-18-6 10635
27 Estrogen Antagonists Phase 3
28 Estrogen Receptor Antagonists Phase 3
29 Aromatase Inhibitors Phase 3
30 Anabolic Agents Phase 3
31
Hydrocortisone Approved, Vet_approved 50-23-7 5754
32
Hydrocortisone acetate Approved, Vet_approved 50-03-3
33
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
34 Calciferol
35 Vitamins
36 Acidophilus
37 Hydrocortisone hemisuccinate
38 Hydrocortisone 17-butyrate 21-propionate
39 Hormones

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 The Influence of Sex Steroid Hormones on Serotonin Transporter Binding in the Human Brain Investigated by Positron Emission Tomography Completed NCT01065220 Phase 4 Testolactone undecanoate;Lynestrenol;Cyproterone Acetate;Estradiol;5-alpha reductase inhibitor
2 Role of Testosterone and Its Metabolites Regarding Different Physiological Functions in Subjects Affected by Gender Identity Disorder (FtM Transsexuals) Completed NCT00146146 Phase 3 testosterone undecanoate alone;testosterone undecanoate plus letrozole;testosterone undecanoate plus dutasteride
3 Testing of Vitrification Protocols for Ovarian Tissue Harvesting in Female to Male Transsexuals Unknown status NCT03649087
4 A European Network for the Investigation of Gender Incongruence Unknown status NCT01072825
5 Association Study of a SRD5A2 SNP and Transsexualism. Completed NCT00435513
6 Oral Administration of Four Lactobacillus Species Preparation to Improve the Quality of the Neovaginal Flora in Male to Female Transsexual Patients Completed NCT01708148
7 Decrease of Libido of Post-Operative Male-Female Transsexuals and a Healthy Female Control Group Completed NCT00135148
8 Observational Study on the Short- and Long-term Effects of Cross-sex-hormone Treatment on Metabolism and Psychopathology in Transsexuals Patients. Completed NCT02185274
9 A Mixed-Methods Study of Mental Health and Associated Factors in Transgender and Transsexual (Trans) People Completed NCT02119377
10 ZEPHYR: A Prospective Study Evaluating Surgical Outcome After Implantation of the Zephyr ZSI 475 FTM Inflatable Penile Implant in the Neophallus After Female-to-male Sex Reassignment Surgery Recruiting NCT04064671
11 Use of an External Erectile Device in Transgender Man Following Phalloplasty Recruiting NCT03823014
12 Phenotype Modulations Following Treatment With Contrary Sex Hormones Recruiting NCT02518009
13 Transgender In Transition: Metabolism, Behaviour and Psychopathology in Transsexual Patients Following Hormonal Treatment Recruiting NCT04028219

Search NIH Clinical Center for Transsexualism

Genetic Tests for Transsexualism

Anatomical Context for Transsexualism

MalaCards organs/tissues related to Transsexualism:

40
Breast, Ovary, Bone, Brain, Testes, Colon, Testis

Publications for Transsexualism

Articles related to Transsexualism:

(show top 50) (show all 781)
# Title Authors PMID Year
1
[Feminizing Genital Gender-affirmative Surgery in Centralized and Decentralized Health Care Settings - The Hamburg TransCare study]. 61
33063307 2021
2
The ICD-11 classification of gender incongruence of adolescence and adulthood: adequacy among transgender people in Lebanon. 61
32031503 2021
3
[Gender dysphoria in the structure of psychosis]. 61
33728857 2021
4
Hormonal Gender Reassignment Treatment for Gender Dysphoria. 61
33559593 2020
5
Reduction in Mental Health Treatment Utilization Among Transgender Individuals After Gender-Affirming Surgeries: A Total Population Study. 61
31581798 2020
6
[Transsexualism and transgender medicine - what every internal specialist should know about]. 61
32791546 2020
7
Urethral complications after gender reassignment surgery: a systematic review. 61
32488213 2020
8
Transsexualism in Hindu Mythology. 61
33083261 2020
9
Adolescent development and psychosocial functioning after starting cross-sex hormones for gender dysphoria. 61
31762394 2020
10
Does the status quo have to remain? The current legal issues of transsexualism in Poland. 61
32233126 2020
11
Psychiatric disorders in individuals diagnosed with gender dysphoria: A systematic review. 61
31642568 2020
12
Transsexualism hos barn, ungdomar och unga vuxna, del 2 - Utredning och behandling kan ge bättre livskvalitet och psykisk hälsa. 61
31613371 2019
13
Transsexualism hos barn, ungdomar och unga vuxna, del 1 - Multidisciplinärt samarbete har gett bättre kunskapsläge. 61
31613370 2019
14
Psychosocial Resources and Quality of Life in Transgender Women following Gender-Affirming Surgery. 61
31570138 2019
15
Public, health professional and legislator perspectives on the concept of psychiatric disease: a population-based survey. 61
31167856 2019
16
[Chapter 3. Human Rights, Gender and Protection of Family and Private Life]. 61
31210527 2019
17
The Right to Trans-Specific Healthcare in Norway: Understanding the Health Needs of Transgender People. 61
30102359 2019
18
Gender Identity: The Human Right of Depathologization. 61
30889934 2019
19
Genetic Link Between Gender Dysphoria and Sex Hormone Signaling. 61
30247609 2019
20
Sex reassignement with or without surgery. New ethical and juridical pathways. 61
31182698 2019
21
Molecular basis of Gender Dysphoria: androgen and estrogen receptor interaction. 61
30165284 2018
22
Psychiatry's ethical involvement in gender-affirming care. 61
29783857 2018
23
[Assessment of the suppression of puberty in children with gender identity problems]. 61
30380899 2018
24
Temporal Trends in Gender-Affirming Surgery Among Transgender Patients in the United States. 61
29490365 2018
25
Application of embryonic equivalents in male-to-female sex reassignment surgery. 61
30505085 2018
26
Transsexualism: A Different Viewpoint to Brain Changes. 61
29739126 2018
27
[Transsexuality and the process of sexual reassignment from the perspective of male transsex: A qualitative study]. 61
30300126 2018
28
[THE MEDICAL CARE OF TRANSGENDER PEOPLE]. 61
29688644 2018
29
Step by step male to female transsexual surgery. 61
29039892 2018
30
The Clinic of Identifications in the Different Processes of Metamorphosis Into Woman. 61
30459662 2018
31
Transgender Medicare Beneficiaries and Chronic Conditions: Exploring Fee-for-Service Claims Data. 61
29125908 2017
32
Transgender Associations and Possible Etiology: A Literature Review. 61
29503778 2017
33
[Is Sexual Identity Optional? A Study of The Genetics of Transsexuality]. 61
28964001 2017
34
[In-patient hospital care of selected sexual disorders : An analysis of data from the German Federal Statistical Office from 2000 to 2014]. 61
28762121 2017
35
Prevalence, Incidence, and Sex Ratio of Transsexualism in the Autonomous Region of Madrid (Spain) According to Healthcare Demand. 61
28224311 2017
36
BIRTH ORDER AND ANDROPHILIC MALE-TO-FEMALE TRANSSEXUALISM IN BRAZIL. 61
27817755 2017
37
[Trans healthcare : Between depsychopathologization and a needs-based treatment of accompanying mental disorders]. 61
28289794 2017
38
[Dramatic increase of gender dysphoria in youth]. 61
28245038 2017
39
Clinical Management of Gender in Egypt: Intersexuality and Transsexualism. 61
27649696 2017
40
Serum concentrations of brain-derived neurotrophic factor in patients diagnosed with gender dysphoria undergoing sex reassignment surgery. 61
28403322 2017
41
Strange Bedfellows: Anachronisms, Identity Politics, and the Queer Case of Trans. 61
27892825 2017
42
[Psychiatric comorbidities in transsexualism: Study of a Lebanese transgender population]. 61
27017319 2016
43
[Patient Satisfaction after Pitch Elevation and Development of a Therapy Algorithm]. 61
27128640 2016
44
Effects on Voice Fundamental Frequency and Satisfaction with Voice in Trans Men during Testosterone Treatment-A Longitudinal Study. 61
26678122 2016
45
Surgical Outcomes of Erectile Implants After Phalloplasty: Retrospective Analysis of 95 Procedures. 61
27693264 2016
46
The Proposed ICD-11 Gender Incongruence of Childhood Diagnosis: A World Professional Association for Transgender Health Membership Survey. 61
27492343 2016
47
A Review of the Status of Brain Structure Research in Transsexualism. 61
27255307 2016
48
Clinical dimensions of a 'biological concept': transsexualism and the interplay between etiological theory and clinical therapy. 61
27578416 2016
49
Self-injury among trans individuals and matched controls: prevalence and associated factors. 61
25929212 2016
50
[Assessment and management of gender dysphoria in children and adolescents]. 61
27117996 2016

Variations for Transsexualism

Expression for Transsexualism

Search GEO for disease gene expression data for Transsexualism.

Pathways for Transsexualism

GO Terms for Transsexualism

Cellular components related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.46 SRD5A2 CYP21A2 CYP19A1 CYP17A1
2 intracellular membrane-bounded organelle GO:0043231 9.26 SRD5A2 CYP21A2 CYP19A1 CYP17A1
3 organelle membrane GO:0031090 8.92 SRD5A2 CYP21A2 CYP19A1 CYP17A1

Biological processes related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.76 SRD5A2 CYP21A2 CYP19A1 CYP17A1
2 cell-cell signaling GO:0007267 9.65 SRD5A2 ESR2 AR
3 steroid metabolic process GO:0008202 9.5 SRD5A2 CYP21A2 CYP17A1
4 sterol metabolic process GO:0016125 9.43 CYP21A2 CYP19A1
5 sex differentiation GO:0007548 9.4 SRD5A2 CYP17A1
6 intracellular estrogen receptor signaling pathway GO:0030520 9.37 ESR2 AR
7 intracellular steroid hormone receptor signaling pathway GO:0030518 9.26 ESR2 AR
8 androgen biosynthetic process GO:0006702 9.16 SRD5A2 CYP17A1
9 glucocorticoid biosynthetic process GO:0006704 8.96 CYP21A2 CYP17A1
10 steroid biosynthetic process GO:0006694 8.92 SRD5A2 CYP21A2 CYP19A1 CYP17A1

Molecular functions related to Transsexualism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.67 SRD5A2 CYP21A2 CYP19A1 CYP17A1
2 lipid binding GO:0008289 9.63 ESR2 CYP21A2 AR
3 heme binding GO:0020037 9.5 CYP21A2 CYP19A1 CYP17A1
4 nuclear receptor activity GO:0004879 9.48 ESR2 AR
5 oxygen binding GO:0019825 9.43 CYP19A1 CYP17A1
6 iron ion binding GO:0005506 9.43 CYP21A2 CYP19A1 CYP17A1
7 steroid hydroxylase activity GO:0008395 9.4 CYP21A2 CYP19A1
8 monooxygenase activity GO:0004497 9.33 CYP21A2 CYP19A1 CYP17A1
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.13 CYP21A2 CYP19A1 CYP17A1
10 steroid binding GO:0005496 8.8 ESR2 CYP21A2 AR

Sources for Transsexualism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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