MCID: TRN003
MIFTS: 38

Transverse Colon Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Transverse Colon Cancer

MalaCards integrated aliases for Transverse Colon Cancer:

Name: Transverse Colon Cancer 12 15
Malignant Neoplasm of Transverse Colon 70
Malignant Tumor of Transverse Colon 12
Ca Transverse Colon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:261
ICD9CM 34 153.1
SNOMED-CT 67 94105000
ICD10 32 C18.4
UMLS 70 C0153434

Summaries for Transverse Colon Cancer

MalaCards based summary : Transverse Colon Cancer, also known as malignant neoplasm of transverse colon, is related to microinvasive gastric cancer and krukenberg carcinoma. An important gene associated with Transverse Colon Cancer is CEACAM5 (CEA Cell Adhesion Molecule 5), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Vemurafenib Pathway, Pharmacodynamics. The drugs Fluorouracil and Cola have been mentioned in the context of this disorder. Affiliated tissues include colon, lymph node and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Transverse Colon Cancer

Diseases related to Transverse Colon Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 346)
# Related Disease Score Top Affiliating Genes
1 microinvasive gastric cancer 30.2 MLH1 CEACAM5
2 krukenberg carcinoma 29.9 KRT7 KRT20 CEACAM5
3 intestinal obstruction 29.9 KRT7 KRT20 CEACAM5
4 descending colon cancer 29.8 KRAS HRAS CEACAM5
5 appendix adenocarcinoma 29.7 KRT7 KRT20 KRAS HRAS
6 mucinous adenocarcinoma 29.6 MLH1 KRT7 KRT20 KRAS CEACAM5
7 adenoma 29.5 MLH1 KRT7 KRT20 KRAS
8 ascending colon cancer 29.5 MLH1 KRAS HRAS CEACAM5
9 rectum cancer 29.4 MLH1 KRT20 KRAS HRAS CEACAM5
10 colon adenocarcinoma 29.2 PMS2 MLH1 KRT20 KRAS CEACAM5
11 adenocarcinoma 29.2 MLH1 KRT7 KRT20 KRAS HRAS CEACAM5
12 bile duct cancer 28.7 MLH1 KRT7 KRT20 KRAS HRAS CEACAM5
13 thymus adenocarcinoma 10.3 KRT20 CEACAM5
14 thyroid angiosarcoma 10.3 KRT20 CEACAM5
15 pancreatic cystadenocarcinoma 10.2 KRAS CEACAM5
16 urachal adenocarcinoma 10.2 KRAS CEACAM5
17 ovarian cystadenoma 10.2 KRT7 CEACAM5
18 bile acid synthesis defect, congenital, 5 10.2 KRAS CEACAM5
19 syringoma 10.2 KRT7 CEACAM5
20 leukoplakia of penis 10.2 KRT7 CEACAM5
21 bladder benign neoplasm 10.2 KRT7 KRT20
22 ureter adenocarcinoma 10.2 KRT7 CEACAM5
23 mucinous adenofibroma 10.2 KRT7 CEACAM5
24 pancreatic foamy gland adenocarcinoma 10.2 KRT7 CEACAM5
25 malignant acrospiroma 10.2 KRT7 CEACAM5
26 bile duct adenoma 10.2 KRT7 KRT20
27 anal paget's disease 10.2 KRT7 CEACAM5
28 cutaneous mucoepidermoid carcinoma 10.2 KRT7 CEACAM5
29 external ear carcinoma 10.2 KRT7 CEACAM5
30 vulval paget's disease 10.2 KRT7 CEACAM5
31 eccrine adenocarcinoma 10.2 KRT7 CEACAM5
32 renal pelvis adenocarcinoma 10.2 KRT7 CEACAM5
33 bile duct cystadenocarcinoma 10.2 KRT7 CEACAM5
34 papillary squamous carcinoma 10.2 KRT7 CEACAM5
35 adenoid basal cell carcinoma 10.2 KRT7 CEACAM5
36 biliary papillomatosis 10.2 KRT7 CEACAM5
37 bile duct mucoepidermoid carcinoma 10.2 KRT7 CEACAM5
38 pericardium cancer 10.2 KRT7 CEACAM5
39 nephrogenic adenoma of urinary bladder 10.2 KRT7 KRT20
40 clear cell hidradenoma 10.2 KRT7 CEACAM5
41 atrophic vulva 10.2 KRT7 KRT20
42 hidradenoma 10.2 KRT7 CEACAM5
43 hidrocystoma 10.2 KRT7 CEACAM5
44 liver sarcoma 10.2 KRT7 CEACAM5
45 cystitis cystica 10.2 KRT7 KRT20
46 ileus 10.2
47 urinary bladder small cell neuroendocrine carcinoma 10.2 KRT7 KRT20
48 eccrine papillary adenocarcinoma 10.2 KRT7 CEACAM5
49 eyelid carcinoma 10.2 KRT7 KRT20
50 eccrine acrospiroma 10.2 KRT7 CEACAM5

Comorbidity relations with Transverse Colon Cancer via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Ascending Colon Cancer
Cecal Benign Neoplasm Colorectal Cancer
Deficiency Anemia Intestinal Obstruction
Iron Deficiency Anemia Paralytic Ileus
Protein-Energy Malnutrition Rectosigmoid Junction Neoplasm

Graphical network of the top 20 diseases related to Transverse Colon Cancer:



Diseases related to Transverse Colon Cancer

Symptoms & Phenotypes for Transverse Colon Cancer

GenomeRNAi Phenotypes related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-1 9.68 MLH1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.68 TCEA1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.68 MLH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.68 TCEA1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.68 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.68 TCEA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.68 TCEA1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.68 KRT7
9 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.68 MLH1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.68 MLH1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.68 TCEA1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.68 TCEA1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.68 TCEA1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.68 TCEA1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.68 TCEA1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.68 TCEA1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.68 TCEA1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.68 KRT7
19 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.68 KRT7
20 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.68 KRT7 TCEA1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.68 MLH1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.68 KRT7

Drugs & Therapeutics for Transverse Colon Cancer

Drugs for Transverse Colon Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3 51-21-8 3385
2 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective,Single-center,Randomized,Controlled Phase III Clinical Study Comparing Efficacy and Safety of Intraoperative Chemotherapy With 5-Fluorouracil Plus Curative Resection Versus Surgery Alone for Patients With Colorectal Cancer Unknown status NCT01465451 Phase 3 intra-operative 5-FU chemotherapy
2 Randomized Controlled Trial to Evaluate Laparoscopic Versus Open Surgery in Transverse and Descending Colon Cancer Patients Unknown status NCT01861691 Phase 2
3 Comparison of D2 vs D3 Lymph Node Dissection for Right Colon Cancer (RICON) Recruiting NCT03200834
4 An Open, Single-arm, Single Center, Clinical Trial to Investigate the Feasibility and Safety of Laparoscopic Ileocecus-sparing Right Hemicolectomy for Hepatic Flexure and Proximal Transverse Colon Cancers Not yet recruiting NCT04479111

Search NIH Clinical Center for Transverse Colon Cancer

Genetic Tests for Transverse Colon Cancer

Anatomical Context for Transverse Colon Cancer

MalaCards organs/tissues related to Transverse Colon Cancer:

40
Colon, Lymph Node, Liver, Pancreas, Bone Marrow, Cerebellum, Small Intestine

Publications for Transverse Colon Cancer

Articles related to Transverse Colon Cancer:

(show top 50) (show all 276)
# Title Authors PMID Year
1
Distribution of lymph node metastasis and oncological outcomes of mid-transverse colon cancer: extended versus transverse colectomy. 61
33793058 2021
2
[A Case of Transverse Colon Cancer with Metastatic Recurrence in Bilateral Inguinal Lymph Nodes]. 61
33790178 2021
3
Surgical Approach to Transverse Colon Cancer: Analysis of Current Practice and Oncological Outcomes Using the National Cancer Database. 61
33555708 2021
4
Laparoscopic versus open radical resection for transverse colon cancer: evidence from multi-center databases. 61
33507386 2021
5
Inflammatory bowel disease in patients with congenital chloride diarrhoea. 61
33770165 2021
6
Robotic Right Hepatectomy with Portal Vein Thrombectomy for Colorectal Liver Metastasis (with Video). 61
33689134 2021
7
[A Case of Medullary Carcinoma of Transverse Colon Which Resected by Laparoscopic Colectomy]. 61
33597384 2021
8
Establishment of deformable three-dimensional printed models for laparoscopic right hemicolectomy in transverse colon cancer. 61
33634953 2021
9
Surgical management of adenocarcinoma of the transverse colon: What should be the extent of resection? 61
33532677 2021
10
[A Case of Left Transverse Colon Cancer Safely Resected Using Three-Dimensional CT Angiography and Indocyanine Green Fluorography]. 61
33468943 2020
11
[A Case of Local Recurrence of Transverse Colon Cancer Radically Resected by Extended Surgery]. 61
33468838 2020
12
[A Case of Transverse Colon Cancer Undergoing Laparoscopic Right Hemicolectomy after Distal Gastrectomy with Billroth Ⅱ Reconstruction]. 61
33468843 2020
13
[Right Hemicolectomy and Pancreatoduodenectomy for Transverse Colon Cancer Invasion to the Duodenum-A Case Report]. 61
33468758 2020
14
Transverse colon cancer with obstruction in a patient with situs inversus totalis: A case report and review of literature. 61
32994114 2020
15
[A Case of Surgery for Transversal Colon Cancer with Intestinal Malrotation -Visualizing Method of Blood Flow in the Fluorescence Navigation Period]. 61
33468942 2020
16
The Impact of Body Mass Index on the Clinicopathological and Prognostic Factors of Colorectal Cancer in Saudi Arabia. 61
33409036 2020
17
Laparoscopic extended right hemicolectomy with complete mesocolic excision and central vascular ligation for mid-transverse colon cancer. 61
32572663 2020
18
Right hemicolectomy with D3 lymph node dissection for right-sided transverse colon cancer using the Senhance robotic system: a case report. 61
33026545 2020
19
Robotic complete mesocolic excision for transverse colon cancer can be performed with a morbidity profile similar to that of conventional laparoscopic colectomy. 61
32495252 2020
20
[A Case of Neoadjuvant Chemotherapy with Modified FOLFOXIRI plus Bevacizumab for Transverse Colon Cancer with Invasion of the Gastric Antrum]. 61
33130754 2020
21
Colonic splenic flexure carcinoma: is laparoscopic segmental resection a safe enough oncological approach? 61
31617095 2020
22
Mid-transverse colon cancer and extended versus transverse colectomy: Results of the Italian society of surgical oncology colorectal cancer network (SICO CCN) multicenter collaborative study. 61
32220542 2020
23
Which is more important in the management of splenic flexure colon cancer: strict central lymph node dissection or adequate bowel resection margin? 61
32548666 2020
24
Evaluation of Prognostic Factors for Survival in Transverse Colon Cancer. 61
32872561 2020
25
Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report. 61
32748092 2020
26
Laparoscopic complete mesocolic excision for mid-transverse colon cancer - a video vignette. 61
32037651 2020
27
[Transverse Colon Cancer with Peritoneal Metastasis Successfully Treated with mFOLFOX6 plus Bevacizumab-A Case Report]. 61
32668867 2020
28
The feasibility and safety of complete laparoscopic extended right hemicolectomy with preservation of the ileocecal junction in right-transverse colon cancer. 61
32635945 2020
29
Anesthetic management of laparoscopy-assisted total proctocolectomy in a cardiac sarcoidosis patient with a cardiac resynchronization therapy-defibrillator: a case report. 61
32506211 2020
30
[Resection of Metastatic Lung Tumor with a Right Displaced Segmental Bronchus (B1+3);Report of a Case]. 61
32398399 2020
31
Spontaneous regression of advanced transverse colon cancer with remaining lymph node metastasis. 61
32394212 2020
32
The re-evaluation of optimal lymph node yield in stage II right-sided colon cancer: is a minimum of 12 lymph nodes adequate? 61
31996986 2020
33
Comparing the safety, efficacy, and oncological outcomes of laparoscopic and open colectomy in transverse colon cancer: a meta-analysis. 61
31980872 2020
34
Multiple liver metastases with synchronous gastric and transverse colon cancer diagnosed by gastric perforation successfully treated by SOX plus bevacizumab and completely resected by surgery: a case report. 61
32180030 2020
35
[Laparoscopic Partial Colectomy for Transverse Colon Cancer after Open Laparotomy for Gastric Cancer Resection]. 61
32381996 2020
36
A pathological complete response after neoadjuvant triplet chemotherapy for locally advanced transverse colon cancer. 61
32535526 2020
37
A case of transverse colon cancer with a large liver abscess that could be treated with a radical operation after infection control. 61
33166816 2020
38
Long-Term Outcomes of Radical Surgery for Transverse Colon Cancer Staged from I to IIIC. 61
33376398 2020
39
[Recurrence-Free Survival after Repeated Resections for Metastatic Inguinal Tumor in Colorectal Mucinous Adenocarcinoma-A Case Report]. 61
32381879 2020
40
Characteristic radiological findings indicating the possible involvement of the hepatic hilar lymph nodes in patients with colorectal liver metastasis: Case report. 61
32506021 2020
41
Mesocolic hernia after laparoscopic transverse colectomy: A case report. 61
31838433 2020
42
[Transverse Colectomy with D2 Lymph Node Dissection with a Small Incision Using Body Surface 3D-Simulation CT Colonography]. 61
32156908 2019
43
[Successful Management of Deep Vein Thromboembolism and Pulmonary Embolism by Edoxaban for Long-Term 5-FU-Based Chemotherapy for Colon Cancer-A Case Report]. 61
31879408 2019
44
[Anastomotic Recurrence after Curative Resection for Transverse Colon Cancer-A Case Report]. 61
32156883 2019
45
[A Case of Two Curative Resections for the Peritoneal Dissemination of Transverse Colon Cancer]. 61
32156971 2019
46
Advanced transverse colon cancer highly indicative of invasion to the duodenum and pancreas. 61
31788303 2019
47
Does transverse colon cancer spread to the extramesocolic lymph node stations? 61
31701816 2019
48
A case of portal venous gas after obstructive transverse colon cancer surgery. 61
31705218 2019
49
Surgical and survival outcomes of laparoscopic colectomy for trans-verse colon cancer in elderly patients. 61
31786847 2019
50
Urgent robotic mesocolic excision for obstructing proximal transverse colon cancer - a video vignette. 61
31116470 2019

Variations for Transverse Colon Cancer

Expression for Transverse Colon Cancer

Search GEO for disease gene expression data for Transverse Colon Cancer.

Pathways for Transverse Colon Cancer

GO Terms for Transverse Colon Cancer

Cellular components related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.96 PMS2 MLH1
2 MutLalpha complex GO:0032389 8.62 PMS2 MLH1

Biological processes related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair GO:0006298 9.26 PMS2 MLH1
2 regulation of long-term neuronal synaptic plasticity GO:0048169 9.16 KRAS HRAS
3 somatic hypermutation of immunoglobulin genes GO:0016446 8.96 PMS2 MLH1
4 response to isolation stress GO:0035900 8.62 KRAS HRAS

Molecular functions related to Transverse Colon Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatched DNA binding GO:0030983 8.96 PMS2 MLH1
2 MutSalpha complex binding GO:0032407 8.62 PMS2 MLH1

Sources for Transverse Colon Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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