MCID: TRN034
MIFTS: 47

Transverse Myelitis

Categories: Immune diseases, Infectious diseases, Nephrological diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Transverse Myelitis

MalaCards integrated aliases for Transverse Myelitis:

Name: Transverse Myelitis 12 73 20 53 15
Myelitis, Transverse 70
Myelitis Transverse 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0080743
UMLS 70 C0026976

Summaries for Transverse Myelitis

GARD : 20 Transverse myelitis is a neurological disorder caused by inflammation of the spinal cord, which carries nerve signals from the brain to the rest of the body. The segment of the spinal cord that has inflammation or damage determines the symptoms a person has. Generally, inflammation at one segment causes symptoms at that level and below that level. Most commonly, the upper spinal cord is affected, causing impaired leg movement, and problems controlling the bowel and bladder. The onset of symptoms may be acute (sudden, developing over hours or days) or subacute (developing over weeks). The cause of transverse myelitis may be unknown (idiopathic) or it may be associated with a wide variety of underlying health problems, including infections, immune system disorders, and other inflammatory disorders. Tests that may be used to diagnose transverse myelitis include MRI to look for compression or inflammation of the spinal cord, and a lumbar puncture (spinal tap) to look for evidence of inflammation in the fluid surrounding the spinal cord (cerebrospinal fluid). Treatment options may include intravenous steroids, pain medicines, plasmapheresis (also called plasma exchange), intravenous immunoglobulin (IVIG), and cyclophosphamide. Some people have full or partial recovery from symptoms, while others do not recover any lost function in the affected parts of the body. Most people recover at least partially, although recovery can take up to 2 or 3 years. In general however, if there is no improvement within the first 6 months, a significant recovery is not likely.

MalaCards based summary : Transverse Myelitis, also known as myelitis, transverse, is related to neuromyelitis optica and acute transverse myelitis. An important gene associated with Transverse Myelitis is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Mitoxantrone and Interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone marrow, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A myelitis that is characterized by a band-like sensation across the trunk of the body, with sensory changes below.

NINDS : 53 Transverse myelitis is an inflammation of the spinal cord. The inflammation interrupts communications between nerve fibers in the spinal cord and the rest of the body, affectng sensation and nerve signaling below the damage to the protective nerve coating called myelin. The segment of the spinal cord at which the damage occurs determines which parts of the body are affected. Damage at one segment will affect function at that level and below. In people with transverse myelitis, the myelin damage most often occurs in nerves in the upper back, causing problems with leg movement and bowel and bladder control, which require signals from the lower segments of the spinal cord.  Symptoms may develop suddenly or over days or weeks. Classic symptoms include: weakness of the arms and legs, sensory alterations such as burning, pricking, numbness, or sensory loss, pain (usually in the lower back or down the legs and arms or around the torso),  and bowel and bladder dysfunction. Some cases of transverse myelitis occur on their own, but a number of conditions appear to cause the disorder, including immune system disorders, bacteial and viral infections, fungal infections, and various parasites.  Transverse myelitis can affect people of any age, but a peak in incidence rates appears to occur between 10 and 19 years of age and 30 to 39 years of age.

Wikipedia : 73 Transverse myelitis (TM) is a rare neurological condition in which the spinal cord is inflamed.... more...

Related Diseases for Transverse Myelitis

Diseases in the Transverse Myelitis family:

Acute Transverse Myelitis

Diseases related to Transverse Myelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 860)
# Related Disease Score Top Affiliating Genes
1 neuromyelitis optica 31.7 MOG MBP IL6 IL17A CD27 AQP4
2 acute transverse myelitis 31.4 MMP9 MMP2 IL6 IL10 CXCL8 AQP4
3 vasculitis 30.9 TNF IL6 IL17A APOH
4 schistosomiasis 30.9 TNF IL17A IL10
5 lyme disease 30.7 TNF MMP9 IL6 IL17A
6 mumps 30.7 TNF IL6 IL10 CXCL8
7 neurosarcoidosis 30.7 TNF MOG AQP4
8 guillain-barre syndrome 30.7 TNF MOG MBP IL17A
9 scrub typhus 30.6 TNF IL17A IL10
10 severe acute respiratory syndrome 30.6 TNF IL6 IL10 CXCL8
11 neurosyphilis 30.6 IL17A IL10 CXCL8
12 spinal cord injury 30.5 TNF MMP9 IL6 CXCL8 AQP4
13 systemic autoimmune disease 30.5 MMP9 IL6 IL17A
14 aseptic meningitis 30.5 TNF IL10 CXCL8
15 encephalitis 30.5 TNF MOG IL6 IL10 AQP4
16 cerebritis 30.5 TNF AQP4 APOH
17 polyradiculoneuropathy 30.5 MBP IL17A IL10
18 mixed connective tissue disease 30.5 TNF IL6 IL10 APOH
19 arachnoiditis 30.5 TNF AQP4
20 polyneuropathy 30.4 TNF MBP IL6 APOA1
21 rubella 30.4 TNF MOG IL6 IL10
22 tuberculous meningitis 30.4 TNF MMP9 CXCL8
23 pulmonary tuberculosis 30.4 TNF IL6 IL10
24 typhoid fever 30.3 TNF IL6 CCR6
25 miller fisher syndrome 30.3 TNF AQP4 AMPH
26 arteriovenous malformation 30.2 TNF MMP9 MMP2 IL6
27 intracranial hypertension 30.2 TNF AQP4 APOH
28 dengue hemorrhagic fever 30.2 TNF IL6 IL10 CXCL8
29 radiculopathy 30.2 IL6 IL17A IL10 CXCL8
30 syphilis 30.2 TNF IL6 IL17A CCR6 APOH
31 neutropenia 30.2 TNF IL6 IL10 CXCL8
32 melioidosis 30.1 TNF IL6 IL10
33 pertussis 30.1 TNF IL6 IL10 CXCL8
34 graft-versus-host disease 30.1 TNF IL6 IL10
35 acute disseminated encephalomyelitis 30.1 MOG MBP IL10 CCR6 AQP4
36 pneumonia 30.1 TNF IL6 IL17A IL10 CXCL8
37 meningitis 30.1 TNF MMP9 IL6 IL17A IL10 CXCL8
38 brucellosis 30.1 TNF IL6 IL17A IL10 CXCL8
39 cerebral palsy 30.1 TNF IL6 IL10 CXCL8
40 meningoencephalitis 30.1 TNF MBP IL6 IL10 CCR6
41 respiratory failure 30.1 TNF IL6 IL10 CXCL8 CCR6
42 tetanus 30.1 TNF MBP IL6 IL10 CD27
43 optic neuritis 30.1 TNF MOG MBP IL6 IL10 CXCL8
44 herpes zoster 30.1 TNF IL10 ICOSLG CCR6
45 diarrhea 30.1 TNF IL6 IL10 CXCL8
46 infective endocarditis 30.0 TNF IL6 IL17A APOH
47 sarcoidosis 1 30.0 TNF ICOSLG CD27 CCR6
48 purpura 30.0 TNF IL6 IL10 APOH
49 cryoglobulinemia 30.0 TNF IL6 CD27 APOH
50 sleeping sickness 30.0 IL6 IL10 APOA1

Graphical network of the top 20 diseases related to Transverse Myelitis:



Diseases related to Transverse Myelitis

Symptoms & Phenotypes for Transverse Myelitis

MGI Mouse Phenotypes related to Transverse Myelitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 AQP4 CCR6 CD27 IL10 IL17A IL6
2 immune system MP:0005387 9.7 AQP4 CCR6 CD27 IL10 IL17A IL6
3 respiratory system MP:0005388 9.17 AQP4 IL10 IL17A IL6 MMP2 MMP9

Drugs & Therapeutics for Transverse Myelitis

Drugs for Transverse Myelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
2
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
3 Immunologic Factors Phase 4
4 Analgesics Phase 4
5 Adjuvants, Immunologic Phase 4
6 Antiviral Agents Phase 4
7 interferons Phase 4
8 Interferon-beta Phase 4
9 Anti-Infective Agents Phase 4
10
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
11
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
12
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
13
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
14
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
15
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
16 Gastrointestinal Agents Phase 3
17 Immunoglobulins Phase 3
18 Antibodies Phase 3
19 Neuroprotective Agents Phase 3
20 Antiemetics Phase 3
21 gamma-Globulins Phase 3
22 Hormone Antagonists Phase 3
23 Immunoglobulins, Intravenous Phase 3
24 Methylprednisolone Acetate Phase 3
25 Hormones Phase 3
26 glucocorticoids Phase 3
27 Rho(D) Immune Globulin Phase 3
28 Anti-Inflammatory Agents Phase 3
29 Protective Agents Phase 3
30
4-Aminopyridine Approved Phase 2 504-24-5 1727
31 Potassium Channel Blockers Phase 2
32
rituximab Approved Phase 1 174722-31-7 10201696
33
Bevacizumab Approved, Investigational Phase 1 216974-75-3
34 Antineoplastic Agents, Immunological Phase 1
35 Antirheumatic Agents Phase 1
36 Angiogenesis Inhibitors Phase 1
37 Antibodies, Monoclonal Phase 1
38 Autoantibodies

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic's Disease) Completed NCT00304291 Phase 4 Mitoxantrone
2 Controlled High-risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurologic Surveillance (CHAMPIONS10) Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
3 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
4 A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin (IVIg) Versus Standard Therapy for the Treatment of Transverse Myelitis in Adults and Children Terminated NCT02398994 Phase 3 Intravenous Methylprednisolone;Intravenous Immunoglobulin
5 Double-Blind, Placebo-Controlled Crossover Trial on the Safety and Efficacy of Sustained-Release Dalfampridine in Transverse Myelitis (Re-Launch) Completed NCT02166346 Phase 2 Dalfampridine;Placebo
6 Home Based Tele-exercise for People With Chronic Neurological Impairments Recruiting NCT04564495 Phase 1, Phase 2
7 A Phase 1/2a Open-Label Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Transverse Myelitis (TM) Not yet recruiting NCT03887273 Phase 1, Phase 2
8 A Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Safety and Efficacy of ABX-1431 in Patients With Central Pain Completed NCT03138421 Phase 1 ABX-1431 HCl;Placebo
9 Open Label Study of Safety and Tolerability of Rituximab in Neuromyelitis Optica, Recurrent Transverse Myelitis and Recurrent Bilateral Simultaneous Optic Neuritis Completed NCT00501748 Phase 1 Rituximab
10 An Open-label Phase 1b Study of Avastin® (Bevacizumab) for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD). Completed NCT01777412 Phase 1 Bevacizumab
11 Phase I, Single-Center, Open Label Trial of Ublituximab + Glucocorticoids for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) Completed NCT02276963 Phase 1 Ublituximab
12 Injured Spinal Cord Pressure Evaluation Study - Transverse Myelitis Completed NCT03336762
13 Evaluating the Effectiveness of a Serious Game to Enhance Self-Management Skills Among Adolescents and Young Adults With Spinal Cord Dysfunction Completed NCT02341950
14 Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study Recruiting NCT02144935
15 PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. Recruiting NCT03942952
16 Collaboration on Neuroimmunology: Question, Understand, Educate, Restore - The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders Recruiting NCT01623076
17 Large-scale, Multi-disciplinary Sample and Data Repository for Multiple Sclerosis and Related Demyelinating Diseases Active, not recruiting NCT00445367
18 A Prospective Observational Study of Maintenance Plasma Exchange (PLEX) for Neuromyelitis Optica Spectrum Disorders (MultiPLEX Study) Active, not recruiting NCT01500681
19 CCRC: Serum Auto-Antibodies in Neurological Disease Enrolling by invitation NCT00704626

Search NIH Clinical Center for Transverse Myelitis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Baclofen

Genetic Tests for Transverse Myelitis

Anatomical Context for Transverse Myelitis

MalaCards organs/tissues related to Transverse Myelitis:

40
Spinal Cord, Brain, Bone Marrow, Breast, Kidney, Thyroid, Skin

Publications for Transverse Myelitis

Articles related to Transverse Myelitis:

(show top 50) (show all 2236)
# Title Authors PMID Year
1
Aquaporin-4 antibody positive longitudinally extensive transverse myelitis following varicella zoster infection. 61 54
18805556 2009
2
Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis. 61 54
18625857 2008
3
A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. 54 61
18509235 2008
4
Neuromyelitis optica pathogenesis and aquaporin 4. 61 54
18510734 2008
5
Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. 54 61
17439296 2007
6
Acute childhood hemiplegia associated with chickenpox and elevated anticardiolipin antibody. 54 61
17005107 2006
7
Simultaneous deep vein thrombosis and transverse myelitis with negative serology as a first sign of antiphospholipid syndrome: a case report and review of the literature. 61 54
16234992 2006
8
Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis. 61 54
10357888 1999
9
[Bilateral optic neuritis and transverse myelitis associated with anticardiolipin antibodies]. 54 61
8183007 1994
10
Transverse myelitis: a manifestation of systemic lupus erythematosus strongly associated with antiphospholipid antibodies. 61 54
2313670 1990
11
Prognostic factors for relapse and outcome in pediatric acute transverse myelitis. 61
33509615 2021
12
MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders. 61
32755221 2021
13
Neuromyelitis Optica Presenting as Infectious Meningoencephalitis: Case Report and Literature Review. 61
33342552 2021
14
Acute transverse myelitis with Dysautonomia following SARS-CoV-2 infection: A case report and review of literature. 61
33640717 2021
15
Primary Central Nervous System Lymphoma Mimicking Longitudinally Extensive Transverse Myelitis. 61
33791064 2021
16
Pediatric acute demyelinating syndromes: identification and management in the emergency department. 61
33617213 2021
17
[Differential diagnostics of autoimmune inflammatory spinal cord diseases]. 61
33765163 2021
18
Population-based head-to-head comparison of the clinical characteristics and epidemiology of AQP4 antibody-positive NMOSD between two European countries. 61
33714126 2021
19
Acute paraplegia in patient with spinal dural arteriovenous fistula after lumbar puncture and steroid administration: A case report. 61
33770639 2021
20
The efficacy of therapeutic apheresis in patients with refractory neuromyelitis optica spectrum disorders: a single-center retrospective study. 61
33752428 2021
21
Meningitis as a recurrent manifestation of anti-AQP4/anti-MOG negative neuromyelitis optica spectrum disorder: a case report. 61
33750325 2021
22
Estimating Baseline Incidence of Conditions Potentially Associated with Vaccine Adverse Events: a Call for Surveillance System Using the Korean National Health Insurance Claims Data. 61
33686812 2021
23
Acute transverse myelitis after SARS-CoV-2 infection: a rare complicated case of rapid onset paraplegia. 61
33650074 2021
24
[Inflammatory spinal cord diseases and transverse myelitis]. 61
33570678 2021
25
Hiccups, severe vomiting and longitudinally extensive transverse myelitis in a patient with prostatic adenocarcinoma and Aquaporin-4 antibodies. 61
33498007 2021
26
Acute transverse myelitis attributed to SARS-CoV-2 infection presenting as impaired mobility: a case report. 61
33646523 2021
27
Characterizing the incidence of adverse events of special interest for COVID-19 vaccines across eight countries: a multinational network cohort study. 61
33791732 2021
28
Spinal cord involvement in COVID-19: A review. 61
33705268 2021
29
Neurological manifestations of coronavirus disease 2019: exploring past to understand present. 61
33428055 2021
30
Neurology of inflammatory bowel disease. 61
33810878 2021
31
Neurobrucellosis with ischemic stroke and spinal cord involvement: a case report. 61
33743640 2021
32
Detect it so you can treat it: A case series and proposed checklist to detect neurotoxicity in checkpoint therapy. 61
33604462 2021
33
Post-COVID-19 encephalomyelitis. 61
33722301 2021
34
Early factors associated with later conversion to multiple sclerosis in patients presenting with isolated myelitis. 61
33687973 2021
35
Incidence Rates of Autoimmune Diseases in European Healthcare Databases: A Contribution of the ADVANCE Project. 61
33462778 2021
36
A case of longitudinally extensive transverse myelitis in an 80-year-old patient with systemic lupus erythematous and anti-aquaporin 4 antibodies. 61
33812223 2021
37
Reversible Cerebral Vasculopathy, Transverse Myelitis, and Active Systemic Lupus Erythematosus in an Aquaporin-4 Antibody-Positive Patient. 61
33468561 2021
38
Myelitis and Other Autoimmune Myelopathies. 61
33522737 2021
39
Spinal Cord Anatomy and Localization. 61
33522735 2021
40
Microsurgical Treatment of a Complex Cognard V Tentorial Dural Fistula with Superior Cerebellar Artery Supply. 61
33080403 2021
41
Anti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience. 61
33388560 2021
42
Bright spotty lesions as an imaging marker for neuromyelitis optica spectrum disorder. 61
33635151 2021
43
Vascular Myelopathies. 61
33522736 2021
44
Spinal fistulas documented by contrast enhanced computed tomography during myelopathy workup: a lost opportunity. 61
33196864 2021
45
Compressive Cervical Myelopathy in Patients With Demyelinating Disease of the Central Nervous System: Improvement After Surgery Despite a Late Diagnosis. 61
33728163 2021
46
Atypical myelitis in patients with multiple sclerosis: Characterization and comparison with typical multiple sclerosis and neuromyelitis optica spectrum disorders. 61
32077365 2021
47
Clinical and neuroimaging characteristics of MOG autoimmunity in children with acquired demyelinating syndromes. 61
33636614 2021
48
Primary progression in NMOSD. Does it really exist? 61
33450529 2021
49
Etiological spectrum, clinico-radiological profile and treatment outcomes of longitudinally extensive transverse myelitis - A prospective study from Northwest India. 61
33341581 2021
50
Delayed diagnosis of spinal cord schistosomiasis in a non-endemic country: A tertiary referral centre experience. 61
33571228 2021

Variations for Transverse Myelitis

Expression for Transverse Myelitis

Search GEO for disease gene expression data for Transverse Myelitis.

Pathways for Transverse Myelitis

Pathways related to Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 TNF MMP9 MMP2 IL6 IL17A IL10
2
Show member pathways
13.36 TNF IL6 IL17A IL10 CXCL8 CD27
3
Show member pathways
13.32 TNF MMP9 MMP2 IL6 IL17A IL10
4
Show member pathways
13.26 TNF IL6 IL17A IL10 CXCL8 CD27
5
Show member pathways
13.16 TNF MMP9 IL6 IL10 CXCL8 APOA1
6
Show member pathways
12.83 TNF IL6 IL17A IL10 ICOSLG CXCL8
7
Show member pathways
12.57 TNF MMP2 IL6 IL17A IL10
8
Show member pathways
12.3 TNF MMP9 IL6 IL17A CXCL8
9
Show member pathways
12.29 TNF IL6 IL10 CXCL8 CCR6
10
Show member pathways
12.25 TNF IL6 IL17A IL10 CXCL8
11 12.17 TNF MMP9 MMP2 IL6
12 12.1 TNF IL6 IL10 CXCL8 AQP4
13 12.07 TNF IL6 IL10 CXCL8
14 11.91 TNF IL6 IL10 CXCL8
15 11.89 TNF MMP2 IL6 CXCL8
16
Show member pathways
11.86 TNF MMP9 MMP2
17 11.85 TNF IL6 IL17A CXCL8
18
Show member pathways
11.83 IL6 IL17A CXCL8
19 11.75 MMP9 MMP2 CXCL8
20 11.75 TNF IL17A IL10 CCR6
21 11.72 TNF IL6 IL10
22
Show member pathways
11.72 TNF IL6 IL17A IL10
23 11.71 MMP9 MMP2 CXCL8
24 11.71 TNF IL6 IL10 CXCL8
25 11.63 MMP9 MMP2 CXCL8
26 11.62 MMP9 MMP2 IL6 CXCL8
27 11.59 TNF IL6 CXCL8
28 11.57 MMP2 IL6 CXCL8
29 11.54 TNF MMP2 IL6
30 11.54 TNF IL6 IL10 ICOSLG CCR6
31 11.51 TNF MMP9 MBP IL6 CXCL8 AQP4
32 11.48 TNF IL6 IL10 CXCL8
33 11.45 TNF IL6 IL10 CXCL8
34
Show member pathways
11.45 TNF MMP9 MMP2 IL6 CXCL8
35 11.42 TNF MMP9 MMP2 IL6
36 11.35 TNF IL6 IL10
37 11.35 TNF MMP9 MMP2 IL6 CXCL8
38 11.3 TNF IL6 IL17A
39 11.27 TNF IL6 IL10 APOA1
40 11.26 TNF IL6 IL10
41 11.22 TNF MMP9 MMP2 IL6 IL17A IL10
42 11.2 MMP9 MMP2 IL6 CXCL8
43 11.03 TNF IL6 CXCL8
44 10.98 TNF IL6 IL17A IL10 CXCL8

GO Terms for Transverse Myelitis

Cellular components related to Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TNF MMP9 MMP2 IL6 IL17A IL10
2 cell surface GO:0009986 9.73 TNF MBP CD27 CCR6 APOH APOA1
3 extracellular region GO:0005576 9.7 TNF MMP9 MMP2 IL6 IL17A IL10
4 external side of plasma membrane GO:0009897 9.17 TNF MOG IL17A ICOSLG CD27 CCR6

Biological processes related to Transverse Myelitis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.76 TNF IL6 IL10 CXCL8
2 response to glucocorticoid GO:0051384 9.71 TNF IL6 IL10
3 immune response GO:0006955 9.7 TNF MBP IL6 IL17A IL10 CXCL8
4 positive regulation of smooth muscle cell proliferation GO:0048661 9.69 TNF MMP2 IL6
5 humoral immune response GO:0006959 9.67 TNF IL6 CCR6
6 positive regulation of interleukin-6 production GO:0032755 9.67 TNF MBP IL6 IL17A
7 positive regulation of interleukin-1 beta production GO:0032731 9.65 TNF IL6 IL17A
8 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL6
9 positive regulation of JAK-STAT cascade GO:0046427 9.61 TNF IL6 IL10
10 regulation of neuroinflammatory response GO:0150077 9.6 MMP9 IL6
11 cellular response to UV-A GO:0071492 9.59 MMP9 MMP2
12 response to molecule of bacterial origin GO:0002237 9.58 IL10 CXCL8
13 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.58 TNF MBP
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 TNF IL6 IL17A
15 positive regulation of lipoprotein lipase activity GO:0051006 9.57 APOH APOA1
16 negative regulation of lipid storage GO:0010888 9.56 TNF IL6
17 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.56 TNF MMP9 MMP2 IL10
18 endothelial cell apoptotic process GO:0072577 9.55 TNF IL10
19 vascular endothelial growth factor production GO:0010573 9.52 TNF IL6
20 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.5 MBP IL10 APOA1
21 cytokine-mediated signaling pathway GO:0019221 9.17 TNF MMP9 MMP2 IL6 IL17A IL10
22 negative regulation of cytokine production involved in immune response GO:0002719 9.13 TNF IL10 APOA1

Molecular functions related to Transverse Myelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 VPS37A TNF MOG MMP9 MMP2 MBP
2 cytokine activity GO:0005125 9.02 TNF IL6 IL17A IL10 CXCL8

Sources for Transverse Myelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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