MCID: TRM010
MIFTS: 36

Traumatic Brain Injury

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Aliases & Classifications for Traumatic Brain Injury

MalaCards integrated aliases for Traumatic Brain Injury:

Name: Traumatic Brain Injury 52 41 2 36 75

Summaries for Traumatic Brain Injury

MedlinePlus: 41 What is traumatic brain injury (TBI)? Traumatic brain injury (TBI) is a sudden injury that causes damage to the brain. It may happen when there is a blow, bump, or jolt to the head. This is a closed head injury. A TBI can also happen when an object penetrates the skull. This is a penetrating injury. Symptoms of a TBI can be mild, moderate, or severe. Concussions are a type of mild TBI. The effects of a concussion can sometimes be serious, but most people completely recover in time. More severe TBI can lead to serious physical and psychological symptoms, coma, and even death. What causes traumatic brain injury (TBI)? The main causes of TBI depend on the type of head injury: Some of the common causes of a closed head injury include Falls. This is the most common cause in adults age 65 and older. Motor vehicle crashes. This is the most common cause in young adults. Sports injuries Being struck by an object Child abuse. This is the most common cause in children under age 4. Blast injuries due to explosions Some of the common causes of a penetrating injury include Being hit by a bullet or shrapnel Being hit by a weapon such as a hammer, knife, or baseball bat A head injury that causes a bone fragment to penetrate the skull Some accidents such as explosions, natural disasters, or other extreme events can cause both closed and penetrating TBI in the same person. Who is at risk for traumatic brain injury (TBI)? Certain groups are at higher risk of TBI: Men are more likely to get a TBI than women. They are also more likely to have serious TBI. Adults aged 65 and older are at the greatest risk for being hospitalized and dying from a TBI What are the symptoms of traumatic brain injury (TBI)? The symptoms of TBI depend on the type of injury and how serious the brain damage is. The symptoms of mild TBI can include: A brief loss of consciousness in some cases. However, many people with mild TBI remain conscious after the injury. Headache Confusion Lightheadedness Dizziness Blurred vision or tired eyes Ringing in the ears Bad taste in the mouth Fatigue or lethargy A change in sleep patterns Behavioral or mood changes Trouble with memory, concentration, attention, or thinking If you have a moderate or severe TBI, you may have those same symptoms. You may also have other symptoms such as: A headache that gets worse or does not go away Repeated vomiting or nausea Convulsions or seizures Not being able to wake up from sleep Larger than normal pupil (dark center) of one or both eyes. This is called dilation of the pupil. Slurred speech Weakness or numbness in the arms and legs Loss of coordination Increased confusion, restlessness, or agitation How is traumatic brain injury (TBI) diagnosed? If you have a head injury or other trauma that may have caused a TBI, you need to get medical care as soon as possible. To make a diagnosis, your health care provider: Will ask about your symptoms and the details of your injury Will do a neurologic exam May do imaging tests, such as a CT scan or MRI May use a tool such as the Glasgow coma scale to determine how severe the TBI is. This scale measures your ability to open your eyes, speak, and move. May do neuropsychological tests to check how your brain is functioning What are the treatments for traumatic brain injury (TBI)? The treatments for TBI depend on many factors, including the size, severity, and location of the brain injury. For mild TBI, the main treatment is rest. If you have a headache, you can try taking over-the-counter pain relievers. It is important to follow your health care provider's instructions for complete rest and a gradual return to your normal activities. If you start doing too much too soon, it may take longer to recover. Contact your provider if your symptoms are not getting better or if you have new symptoms. For moderate to severe TBI, the first thing health care providers will do is stabilize you to prevent further injury. They will manage your blood pressure, check the pressure inside your skull, and make sure that there is enough blood and oxygen getting to your brain. Once you are stable, the treatments may include: Surgery to reduce additional damage to your brain, for example to Remove hematomas (clotted blood) Get rid of damaged or dead brain tissue Repair skull fractures Relieve pressure in the skull Medicines to treat the symptoms of TBI and to lower some of the risks associated with it, such as Anti-anxiety medication to lessen feelings of nervousness and fear Anticoagulants to prevent blood clots Anticonvulsants to prevent seizures Antidepressants to treat symptoms of depression and mood instability Muscle relaxants to reduce muscle spasms Stimulants to increase alertness and attention Rehabilitation therapies, which can include therapies for physical, emotional, and cognitive difficulties: Physical therapy, to build physical strength, coordination, and flexibility Occupational therapy, to help you learn or relearn how to perform daily tasks, such as getting dressed, cooking, and bathing Speech therapy, to help you to with speech and other communication skills and treat swallowing disorders Psychological counseling, to help you learn coping skills, work on relationships, and improve your emotional well-being Vocational counseling, which focuses on your ability to return to work and deal with workplace challenges Cognitive therapy, to improve your memory, attention, perception, learning, planning, and judgment Some people with TBI may have permanent disabilities. A TBI can also put you at risk for other health problems such as anxiety, depression, and post-traumatic stress disorder. Treating these problems can improve your quality of life. Can traumatic brain injury (TBI) be prevented? There are steps you can take to prevent head injuries and TBIs: Always wear your seatbelt and use car seats and booster seats for children Never drive under the influence of drugs or alcohol Wear a properly fitting helmet when riding a bicycle, skateboarding, and playing sports like hockey and football Prevent falls by Making your house safer. For example, you can install railings on the stairs and grab bars in the tub, get rid of tripping hazards, and use window guards and stair safety gates for young children. Improving your balance and strength with regular physical activity

MalaCards based summary: Traumatic Brain Injury is related to moderate and severe traumatic brain injury and ocular motor apraxia. The drugs Acetylsalicylic acid and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include Bone, brain and bone marrow.

NINDS: 52 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

CDC: 2 Traumatic brain injury (TBI) is a serious public health problem in the United States. Each year, traumatic brain injuries contribute to a substantial number of deaths and cases of permanent disability. In 2014, there were approximately 2.87 million TBI-related emergency department visits, hospitalizations, and deaths in the US, including over 837,000 of these health events among children. 1 A TBI is caused by a bump, blow or jolt to the head or a penetrating head injury that disrupts the normal function of the brain. Not all blows or jolts to the head result in a TBI. The severity of a TBI may range from "mild," i.e., a brief change in mental status or consciousness to "severe," i.e., an extended period of unconsciousness or amnesia after the injury. CDC's research and programs work to prevent TBI and help people better recognize, respond, and recover if a TBI occurs.

Wikipedia: 75 A traumatic brain injury (TBI), also known as an intracranial injury, is an injury to the brain caused... more...

Related Diseases for Traumatic Brain Injury

Diseases related to Traumatic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 888)
# Related Disease Score Top Affiliating Genes
1 moderate and severe traumatic brain injury 11.7
2 ocular motor apraxia 11.6
3 apraxia 11.4
4 dementia 11.4
5 post-traumatic stress disorder 11.3
6 locked-in syndrome 11.3
7 post-traumatic epilepsy 11.3
8 cerebral atrophy 11.3
9 hyperphenylalaninemia, bh4-deficient, a 11.3
10 brain edema 11.3
11 amnestic disorder 11.2
12 intracranial hypertension 11.2
13 tremor 11.2
14 obsessive-compulsive disorder 11.2
15 shaken baby syndrome 11.2
16 agnosia 11.2
17 swallowing disorders 11.2
18 prosopagnosia 11.2
19 childhood apraxia of speech 11.2
20 non 24 hour sleep wake disorder 11.2
21 acute stress disorder 11.1
22 hypopituitarism 11.0
23 dementia pugilistica 11.0
24 anxiety 11.0
25 masa syndrome 11.0
26 substance abuse 11.0
27 headache 11.0
28 major depressive disorder 11.0
29 pituitary gland disease 11.0
30 epilepsy 10.9
31 attention deficit-hyperactivity disorder 10.9
32 thrombophilia due to thrombin defect 10.9
33 spinal cord injury 10.9
34 alcohol use disorder 10.9
35 oculodentodigital dysplasia 10.9
36 stroke, ischemic 10.9
37 adult syndrome 10.9
38 visual epilepsy 10.9
39 hydrocephalus 10.9
40 adult respiratory distress syndrome 10.9
41 amyloidosis 10.9
42 alzheimer disease, familial, 1 10.9
43 48,xyyy 10.9
44 encephalopathy 10.9
45 hemorrhage, intracerebral 10.9
46 sleep disorder 10.9
47 spasticity 10.9
48 mood disorder 10.9
49 cognitive function 1, social 10.8
50 chronic pain 10.8

Graphical network of the top 20 diseases related to Traumatic Brain Injury:



Diseases related to Traumatic Brain Injury

Symptoms & Phenotypes for Traumatic Brain Injury

Drugs & Therapeutics for Traumatic Brain Injury

Drugs for Traumatic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 342)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylsalicylic acid Approved, Vet_approved Phase 4 50-78-2 2244
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
3
Cisatracurium Approved, Investigational Phase 4 96946-41-7 62887
4
Venlafaxine Approved Phase 4 99300-78-4, 93413-69-5 5656
5
Ethanol Approved Phase 4 64-17-5 702
6
Amantadine Approved Phase 4 768-94-5 2130
7
Levetiracetam Approved Phase 4 102767-28-2 441341 5284583
8
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
9
Simvastatin Approved Phase 4 79902-63-9 54454
10
Quinidine Approved, Investigational Phase 4 56-54-2, 130-95-0, 804-63-7 1065 441074 3034034 8549
11
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
12
Reviparin Approved, Investigational Phase 4 9041-08-1
13
Citalopram Approved Phase 4 59729-32-7, 59729-33-8 2771
14
Testosterone Approved, Investigational Phase 4 58-22-0 5408 6013
15
Topiramate Approved Phase 4 97240-79-4 5284627
16
Methyltestosterone Approved Phase 4 58-18-4 6010
17
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0 21873174 65157
18
Testosterone enanthate Approved Phase 4 315-37-7 9416
19
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 4 14838-15-4, 492-39-7 131954576 4786 26934
20
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
21
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
22
Dextromethorphan Approved Phase 4 125-71-3 5362449 5360696
23
Nortriptyline Approved Phase 4 72-69-5 4543
24
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
25
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
26
Esketamine Approved, Investigational Phase 4 33643-46-8 182137
27
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
28
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
29
Memantine Approved, Investigational Phase 4 41100-52-1, 19982-08-2 4054
30
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
31
Sorbitol Approved, Investigational Phase 4 69-65-8, 50-70-4 453 6251 5780
32
Hydrocortisone succinate Approved Phase 4 2203-97-6 3643
33
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
34
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 3640 5754
35
Zinc cation Approved, Experimental, Investigational Phase 4 7440-66-6, 23713-49-7 32051
36
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
37
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8 5280382 445354
38
L-Glutamine Approved, Investigational, Nutraceutical Phase 4 56-85-9 5961
39
Ubidecarenone Approved, Investigational, Nutraceutical Phase 4 303-98-0 5281915
40
Dexetimide Withdrawn Phase 4 21888-98-2 30843
41
Cerebrolysin Experimental Phase 4 12656-61-0
42 Analgesics, Non-Narcotic Phase 4
43 Platelet Aggregation Inhibitors Phase 4
44 Antirheumatic Agents Phase 4
45 Anti-Inflammatory Agents Phase 4
46 Antipyretics Phase 4
47 Cyclooxygenase Inhibitors Phase 4
48 Anti-Inflammatory Agents, Non-Steroidal Phase 4
49 Retinol palmitate Phase 4
50 Neuromuscular Blocking Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 1319)
# Name Status NCT ID Phase Drugs
1 Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates? Unknown status NCT03054285 Phase 4 Levetiracetam
2 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
3 MLC901 for Moderate to Severe Traumatic Brain Injury: Pilot, Randomized, Double-Masked, Placebo-controlled Trial Unknown status NCT04487275 Phase 4 MLC901 or Placebo
4 Effect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury Unknown status NCT02321761 Phase 4 Amantadine hydrochloride
5 A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
6 Buspirone and Melatonin for Depression Following Traumatic Brain Injury Unknown status NCT04400266 Phase 4 B+MEL
7 Cerebral Protection of Dexmedetomidine Against Paroxysmal Sympathetic Overexcited in Patients With Traumatic Brain Injury Unknown status NCT04006054 Phase 4 Dexmedetomidine;Midazolam
8 Pilot Study: The Effect of Rozerem on Sleep Disturbance After Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
9 Randomized Controlled Clinical Study of Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
10 Citicholine-Amantadine Trial in Traumatic Brain Injury Unknown status NCT03430817 Phase 4 Citicholine;Amantadine
11 Efficiency and Tolerance of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula in the Critically Ill Patient : a Prospective Randomized Trial Unknown status NCT01833624 Phase 4
12 Normothermia in Patients With Acute Cerebral Damage Unknown status NCT00491192 Phase 4 Diclofenac
13 Effects of Intensive Insulin Therapy on Mortality, Morbidity and Long Term Neurologic Outcome in Neurosurgical Intensive Care Patients Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
14 A Randomised Control Trial to Determine the Effectiveness of Sensory Stimulation Program in Reducing the Length of Time Spent by Severely Brain Injured Patients in a Vegetative State in the Acute Hospital Environment Unknown status NCT00163878 Phase 4
15 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents. A Controlled Randomized Study Versus Placebo Unknown status NCT02404779 Phase 4 cisatracurium besilate
16 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
17 Pharmacological Intervention in Depression After Traumatic Brain Injury (A Research Study Within the Traumatic Brain Injury Model System) Completed NCT00205491 Phase 4 Venlafaxine
18 Phase IV Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury Completed NCT01339806 Phase 4
19 Improvement of Therapy in Patients With Severe Traumatic Brain Injury: Differential Impact of Local and Systemic Changes and Routinely Applied Drugs Completed NCT02130674 Phase 4 Dipeptiven
20 Beta-Adrenergic Blockade for Suppression of Catecholamine Surge Following Traumatic Brain Injury: A Randomized Trial Completed NCT02957331 Phase 4 Propranolol
21 Efficacy of Methylphenidate for Management of Long-Term Attention Problems After Pediatric Traumatic Brain Injury (TBI) Completed NCT01933217 Phase 4 Methylphenidate;Placebo
22 The Control of Brain Networks After Traumatic Brain Injury: a Neuroimaging and Neuropsychological Study of Dopamine and Cognition Completed NCT02015949 Phase 4 Methylphenidate;Placebo
23 Treatment Outcomes With Lisdexamfetamine Dimesylate (Vyvanse) in Children With Traumatic Brain Injury-Related Attention Deficits Completed NCT02712996 Phase 4 Lisdexamfetamine;Placebo
24 Doxycycline Effects on Neurological Outcomes in Patients With Acute Traumatic Brain Injury Completed NCT04239755 Phase 4 Doxycycline 100 MG Oral Tablet
25 Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery Completed NCT00035139 Phase 4 methylphenidate
26 The Use of Low Molecular Weight Heparin in Traumatic Brain Injury Completed NCT00170378 Phase 4 Enoxaparin
27 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Recombinant human growth hormone
28 A 26-Week Open-Label Extension to Protocol No. CENA713BUS11: A 12-Week, Prospective, Double-blind, Placebo-controlled, Multi-center Study Evaluating the Efficacy and Safety of Rivastigmine 3 to 6 mg/Day in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits Completed NCT00219245 Phase 4 Rivastigmine
29 The Serotonin Transporter Gene Polymorphism and Major Depression Following Traumatic Brain Injury Completed NCT00254007 Phase 4 citalopram (celexa)
30 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon: A Prospective Randomized Clinical Trial Injury to Reduce Sympathetic Storm Phenomenon: A Prospective Randomized Clinical Trial Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
31 Potential Impact of Amantadine on Traumatic Brain Injury Outcomes Completed NCT04527289 Phase 4 Amantadine (100mg) as add on therapy.;Placebo
32 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel)
33 Validation of a New Non Invasive Method for Intracranial Pressure Monitoring Completed NCT01685476 Phase 4
34 Simvastatin: Proof-of-Concept for Prevention of Neurodegeneration in Mild TBI Completed NCT01952288 Phase 4 simvastatin;Placebo Oral Tablet
35 Amantadine Hydrochloride for Treatment of Symptoms of the Post-traumatic Confusional State Among Neurorehabilitation Admissions With TBI: A Randomized, Double-Blind, Placebo-Controlled Trial Completed NCT00693121 Phase 4 Amantadine hydrochloride;Placebo capsule
36 Assessment of Seizure Prophylaxis Protocols Using Intravenous Levetiracetam in a Neuroscience Intensive Care Unit Completed NCT00618436 Phase 4 Levetiracetam;Phenytoin
37 Randomized, Placebo-controlled Clinical Trial of Enteral Glutamine Supplementation in Neurologically-injured Patients Completed NCT00204971 Phase 4
38 Bispectral Index Value Changes During Induction and Surgical Decompression in Head Injury Patients Completed NCT03480880 Phase 4
39 Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI Completed NCT01750268 Phase 4 Topiramate;Placebo
40 A Study to Assess the Safety, Tolerability and Effectiveness of Nuedexta (Dextromethorphan 20 mg/Quinidine 10 mg) in the Treatment of Pseudobulbar Affect (PBA) Completed NCT01799941 Phase 4 Nuedexta (DM 20 mg/Q 10 mg)
41 Non-Invasive Vagal Nerve Stimulation in Veterans With Mild Traumatic Brain Injury (mTBI) Recruiting NCT04437498 Phase 4
42 Beta Blocker Effects on Patients With Traumatic Brain Injury Recruiting NCT05195996 Phase 4 Propranolol;Saline
43 Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status: A Randomized Controlled Trial (BBTBBT) Recruiting NCT04508244 Phase 4 Placebo;Propranolol
44 Brain Injury and Ketamine: a Prospective, Randomized Controlled Double Blind Clinical Trial to Study the Effects of Ketamine on Sedative Sparing and Intracranial Pressure in Traumatic Brain Injury Patients. Recruiting NCT05097261 Phase 4 Ketamine;Placebo
45 Safety and Efficacy of MLC901 (NeuroAiD Ii) in Patients With Moderate TBI: A Randomized Double Blind Placebo Controlled Trial Recruiting NCT04766281 Phase 4
46 Treatment for Post-concussive Headache: A Randomized, Placebo-controlled, Double Blinded Trial Enrolling by invitation NCT04226365 Phase 4 Nortriptyline;Placebo
47 Aerosolized Endotracheal Lidocaine to Avoid Intracranial Pressure Spikes in Patients With Severe Traumatic Brain Injury Not yet recruiting NCT05058677 Phase 4 aerosolized 2% lidocaine (20mg/ml);instilled 0.9% sodium chloride (NS);instilled 2% lidocaine solution
48 Combination Treatment With Cerebrolysin and Amantadine on Prolonged Disorders of Consciousness in Patients With Severe Traumatic Brain Injury: A Pilot Study Not yet recruiting NCT04427241 Phase 4 Amantadine Sulfate plus Cerebrolysin;Amantadine Sulfate;Cerebrolysin
49 S-ketamine for Cortical Spreading Depolarisation in Patients With Severe Acute Brain Injury Not yet recruiting NCT05095857 Phase 4 S-ketamine
50 Head Trauma With Traumatic Brain Injury (TBI): A Multicenter, Phase IV Study to Evaluate the Effects of Genotropin in Adult Patients With Growth Hormone Deficiency (GHD) Caused by Trauma and/or Head Injury Terminated NCT00638053 Phase 4

Search NIH Clinical Center for Traumatic Brain Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Traumatic Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Traumatic Brain Injury:
MultiStem, bone marrow-derived cells for neurological disorders
Embryonic/Adult Cultured Cells Related to Traumatic Brain Injury:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 23205020 20637752 23020860 21175285 21248119

Genetic Tests for Traumatic Brain Injury

Anatomical Context for Traumatic Brain Injury

Organs/tissues related to Traumatic Brain Injury:

MalaCards : Brain, Bone Marrow, Bone, Spinal Cord, Pons, Prefrontal Cortex, Eye
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Traumatic Brain Injury:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Traumatic Brain Injury

Articles related to Traumatic Brain Injury:

(show top 50) (show all 30000)
# Title Authors PMID Year
1
Vestibular Rehabilitation Improves Gait Quality and Activities of Daily Living in People with Severe Traumatic Brain Injury: A Randomized Clinical Trial. 62 41
36366250 2022
2
Ballistic resistance training has a similar or better effect on mobility than non-ballistic exercise rehabilitation in people with a traumatic brain injury: a randomised trial. 62 41
36253280 2022
3
Provider perceptions of severe pediatric traumatic brain injury care priorities across hospitals in South America before and during the COVID-19 pandemic. 62 41
36174092 2022
4
Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury. 62
36453402 2023
5
Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury. 62
36254991 2023
6
Endocannabinoid control of neuroinflammation in traumatic brain injury by monoacylglycerol lipase in astrocytes. 62
36254984 2023
7
A benchtop brain injury model using resected donor tissue from patients with Chiari malformation. 62
36254993 2023
8
Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury. 62
36204836 2023
9
Functional phenotyping of microglia highlights the dark relationship between chronic traumatic brain injury and normal age-related pathology. 62
36204847 2023
10
Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury. 62
36018155 2023
11
Brain and spinal cord trauma: what we know about the therapeutic potential of insulin growth factor 1 gene therapy. 62
35900399 2023
12
Knockout of Sirt2 alleviates traumatic brain injury in mice. 62
35900429 2023
13
Orienting network impairment of attention in patients with mild traumatic brain injury. 62
36179805 2023
14
Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats. 62
36330906 2023
15
Modified constraint-induced movement therapy enhances cortical plasticity in a rat model of traumatic brain injury: a resting-state functional MRI study. 62
35900438 2023
16
Simulating traumatic brain injury in vitro: developing high throughput models to test biomaterial based therapies. 62
35900405 2023
17
Repetitive transcranial magnetic stimulation promotes neurological functional recovery in rats with traumatic brain injury by upregulating synaptic plasticity-related proteins. 62
35900432 2023
18
Tandem Mass Tag-based proteomics analysis reveals the vital role of inflammation in traumatic brain injury in a mouse model. 62
35799536 2023
19
The Characteristics of Withdrawal or Withholding of Life-Sustaining Treatment in Severe Traumatic Brain Injury: A Single Japanese Institutional Study. 62
36353247 2023
20
Maraviroc promotes recovery from traumatic brain injury in mice by suppression of neuroinflammation and activation of neurotoxic reactive astrocytes. 62
35799534 2023
21
Catheter-associated deep vein thrombosis in children with severe traumatic brain injury: A single-center experience. 62
36250988 2023
22
Corrigendum to "Identifying traumatic brain injury (TBI) by ATR-FTIR spectroscopy in a mouse model" [Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 274 (2022) 121099]. 62
35715370 2023
23
Development of a novel bioengineered 3D brain-like tissue for studying primary blast-induced traumatic brain injury. 62
36200530 2023
24
Tranexamic acid for traumatic brain injury. 62
36153260 2023
25
Protocadherin gamma C3: a new player in regulating vascular barrier function. 62
35799511 2023
26
A decade of blood-brain barrier permeability assays: Revisiting old traumatic brain injury rat data for new insights and experimental design. 62
36356686 2023
27
Transcranial Magnetic Stimulation and its Imaging Features in Patients With Depression, Post-traumatic Stress Disorder, and Traumatic Brain Injury. 62
35437218 2023
28
Decompressive Craniectomy and Shunt-Amenable Post-Traumatic Hydrocephalus: A Single-Center Experience. 62
36217538 2023
29
Bedside Ultrasound for Ventricular Size Monitoring in Patients with PEEK Cranioplasty: A Preliminary Experience of Technical Feasibility in Neurotrauma Setting. 62
35761126 2022
30
Response to a Letter to the Editor: Incidence and Associated Factors of Anemia in Patients with Acute Moderate and Severe Traumatic Brain Injury. 62
36085344 2022
31
"Communication Is Not Exactly My Field, but It Is Still My Area of Work": Staff and Managers' Experiences of Communication With People With Traumatic Brain Injury. 62
36455235 2022
32
Letter to the Editor: Incidence and Associated Factors of Anemia in Patients with Acute Moderate and Severe Traumatic Brain Injury. 62
36085343 2022
33
The Relationship Between Cognitive Functioning and Symptoms of Depression, Anxiety, and Post-Traumatic Stress Disorder in Adults with a Traumatic Brain Injury: a Meta-Analysis. 62
34694543 2022
34
Prognostic Models in Severe Traumatic Brain Injury: A Systematic Review and Meta-analysis. 62
35941405 2022
35
Insights on the Potential Mechanisms of Action of Functional Electrical Stimulation Therapy in Combination With Task-Specific Training: A Scoping Review. 62
34031937 2022
36
Synergistic effect of mild traumatic brain injury and alcohol aggravates neuroinflammation, amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations: Impact on psychological stress. 62
36089059 2022
37
Correction to: Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury. 62
36180785 2022
38
The AMPK-SIRT1-FoxO1-NF-κB signaling pathway participates in hesperetin-mediated neuroprotective effects against traumatic brain injury via the NLRP3 inflammasome. 62
35786120 2022
39
Post-traumatic catatonia in a teenaged patient. 62
36117015 2022
40
The Effectiveness of Trigeminal Nerve Stimulation on Traumatic Brain Injury. 62
35088758 2022
41
VEGF regulates the blood‑brain barrier through MMP‑9 in a rat model of traumatic brain injury. 62
36382093 2022
42
Obstructive sleep apnea is associated with worse cognitive outcomes in acute moderate-to-severe traumatic brain injury: A TBI Model Systems study. 62
36252414 2022
43
Sport Participation Among Children With Complicated Mild Traumatic Brain Injury. 62
36459541 2022
44
Persistent coagulopathy after gunshot traumatic brain injury: the importance of INR and the SPIN score. 62
35732810 2022
45
Suicide Attempts Assisted By Firefighters According to Traumatic Brain Injury. 62
36038809 2022
46
Traumatic brain injury with concomitant injury to the spleen: characteristics and mortality of a high-risk trauma cohort from the TraumaRegister DGU®. 62
33206232 2022
47
Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury. 62
35717463 2022
48
Prediction of early prognosis after traumatic brain injury by multifactor model. 62
36017774 2022
49
Application of a TEG-Platelet Mapping Algorithm to Guide Reversal of Antiplatelet Agents in Adults with Mild-to-Moderate Traumatic Brain Injury: An Observational Pilot Study. 62
35705826 2022
50
Comparing resting-state connectivity of working memory networks in U.S. Service members with mild traumatic brain injury and posttraumatic stress disorder. 62
36162495 2022

Variations for Traumatic Brain Injury

Expression for Traumatic Brain Injury

Search GEO for disease gene expression data for Traumatic Brain Injury.

Pathways for Traumatic Brain Injury

GO Terms for Traumatic Brain Injury

Sources for Traumatic Brain Injury

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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