MCID: TRM010
MIFTS: 54

Traumatic Brain Injury

Categories: Ear diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Traumatic Brain Injury

MalaCards integrated aliases for Traumatic Brain Injury:

Name: Traumatic Brain Injury 54 43 3 38

Classifications:



Summaries for Traumatic Brain Injury

MedlinePlus : 43 Traumatic brain injury (TBI) happens when a bump, blow, jolt, or other head injury causes damage to the brain. Every year, millions of people in the U.S. suffer brain injuries. More than half are bad enough that people must go to the hospital. The worst injuries can lead to permanent brain damage or death. Half of all TBIs are from motor vehicle accidents. Military personnel in combat zones are also at risk. Symptoms of a TBI may not appear until days or weeks following the injury. A concussion is the mildest type. It can cause a headache or neck pain, nausea, ringing in the ears, dizziness, and tiredness. People with a moderate or severe TBI may have those, plus other symptoms: A headache that gets worse or does not go away Repeated vomiting or nausea Convulsions or seizures Inability to awaken from sleep Slurred speech Weakness or numbness in the arms and legs Dilated eye pupils Health care professionals use a neurological exam and imaging tests to assess TBI. Serious traumatic brain injuries need emergency treatment. Treatment and outcome depend on how severe the injury is. TBI can cause a wide range of changes affecting thinking, sensation, language, or emotions. TBI can be associated with post-traumatic stress disorder. People with severe injuries usually need rehabilitation. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Traumatic Brain Injury is related to head injury and persistent vegetative state. An important gene associated with Traumatic Brain Injury is APOE (Apolipoprotein E), and among its related pathways/superpathways are PAK Pathway and Nanog in Mammalian ESC Pluripotency. The drugs Diclofenac and Cisatracurium have been mentioned in the context of this disorder. Affiliated tissues include Bone, brain and testes, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

CDC : 3 Traumatic brain injury (TBI) is a serious public health problem in the United States. Each year, traumatic brain injuries contribute to a substantial number of deaths and cases of permanent disability. In 2014, there were approximately 2.87 million TBI-related emergency department visits, hospitalizations, and deaths in the US, including over 837,000 of these health events among children. 1 A TBI is caused by a bump, blow or jolt to the head or a penetrating head injury that disrupts the normal function of the brain. Not all blows or jolts to the head result in a TBI. The severity of a TBI may range from "mild," i.e., a brief change in mental status or consciousness to "severe," i.e., an extended period of unconsciousness or amnesia after the injury. CDC's research and programs work to prevent TBI and help people better recognize, respond, and recover if a TBI occurs.

NINDS : 54 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

Wikipedia : 75 Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force injures... more...

Related Diseases for Traumatic Brain Injury

Diseases related to Traumatic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 713)
# Related Disease Score Top Affiliating Genes
1 head injury 33.9 S100B ENO2 APOE
2 persistent vegetative state 33.6 ENO2 APOE
3 obsessive-compulsive disorder 32.2 DRD2 COMT BDNF
4 brain edema 32.1 IL6 GFAP AQP4
5 substance abuse 31.3 DRD2 COMT BDNF
6 post-traumatic stress disorder 31.2 DRD2 COMT BDNF APOE
7 spinal cord injury 31.1 IL6 GFAP CASP3 BDNF AQP4
8 status epilepticus 31.0 GFAP ENO2 CASP3 BDNF
9 hydrocephalus 30.8 MBP IGF1 GFAP ENO2 APOE
10 sleep apnea 30.8 S100B IL6 IGF1 APOE
11 generalized anxiety disorder 30.8 DRD2 COMT BDNF
12 personality disorder 30.7 DRD2 COMT BDNF
13 mood disorder 30.7 IL6 DRD2 COMT BDNF
14 ganglioglioma 30.7 S100B GFAP ENO2
15 chiari malformation 30.6 MBP GFAP
16 finger agnosia 30.5 MBP ENO2
17 psychotic disorder 30.5 S100B DRD2 COMT BDNF
18 neurilemmoma 30.5 S100B GFAP ENO2
19 alexia 30.4 MBP AQP4 APOE
20 stroke, ischemic 30.4 MBP ENO2 CASP3 AQP4 APOE
21 middle cerebral artery infarction 30.4 S100B ENO2
22 alzheimer disease 30.3 UCHL1 S100B GFAP CASP3 BDNF APOE
23 bacterial meningitis 30.3 S100B IL6 IL10
24 major depressive disorder 30.3 IL6 DRD2 COMT BDNF APOE
25 substance dependence 30.3 IL6 DRD2 BDNF
26 central pontine myelinolysis 30.2 MBP AQP4
27 non-functioning pituitary adenoma 30.1 S100B GH1
28 neuroaxonal dystrophy 30.1 MBP IGF1 ENO2
29 eating disorder 30.1 DRD2 COMT BDNF
30 disease of mental health 30.1 IL6 DRD2 COMT BDNF APOE
31 fibromyalgia 30.1 IL6 IGF1 COMT
32 appendicitis 30.0 IL6 IL10 ENO2
33 central precocious puberty 29.9 IGF1 GH1
34 polysubstance abuse 29.8 DRD2 COMT
35 neuromyelitis optica 29.7 MBP IL6 GFAP AQP4
36 schizoaffective disorder 29.7 DRD2 COMT BDNF
37 huntington disease 29.7 IGF1 DRD2 CASP3 BDNF
38 multiple system atrophy 1 29.7 MBP GFAP DRD2
39 hyperprolactinemia 29.6 IGF1 GH1 DRD2
40 gilles de la tourette syndrome 29.6 DRD2 COMT BDNF
41 brain cancer 29.6 MBP GFAP ENO2 CASP3 AQP4
42 demyelinating disease 29.6 MBP IL10 AQP4
43 secondary progressive multiple sclerosis 29.6 S100B MBP IL10 ENO2
44 empty sella syndrome 29.4 IGF1 GH1
45 functioning pituitary adenoma 29.4 S100B GH1 DRD2
46 parkinson disease, late-onset 29.3 UCHL1 DRD2 COMT CASP3 BDNF APOE
47 central nervous system disease 29.2 MBP IL6 GFAP CASP3 BDNF AQP4
48 multiple sclerosis 28.9 MBP IL6 IL10 GFAP BDNF AQP4
49 body mass index quantitative trait locus 11 28.5 IL6 IGF1 GH1 DRD2 APOE
50 osteoporosis 28.4 IL6 IGF1 GH1 APOE

Graphical network of the top 20 diseases related to Traumatic Brain Injury:



Diseases related to Traumatic Brain Injury

Symptoms & Phenotypes for Traumatic Brain Injury

GenomeRNAi Phenotypes related to Traumatic Brain Injury according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 IL10
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Traumatic Brain Injury:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.4 APOE AQP4 BDNF CASP3 COMT DRD2
2 growth/size/body region MP:0005378 10.36 APOE AQP4 BDNF CASP3 DRD2 ENO2
3 cardiovascular system MP:0005385 10.32 APOE AQP4 CASP3 COMT DRD2 GFAP
4 cellular MP:0005384 10.32 APOE BDNF CASP3 DRD2 ENO2 GFAP
5 homeostasis/metabolism MP:0005376 10.32 APOE AQP4 BDNF CASP3 COMT DRD2
6 nervous system MP:0003631 10.25 APOE AQP4 BDNF CASP3 COMT DRD2
7 mortality/aging MP:0010768 10.23 APOE AQP4 BDNF CASP3 DRD2 GFAP
8 digestive/alimentary MP:0005381 10.22 APOE AQP4 BDNF CASP3 DRD2 GFAP
9 hematopoietic system MP:0005397 10.22 APOE AQP4 CASP3 COMT DRD2 IGF1
10 endocrine/exocrine gland MP:0005379 10.21 APOE AQP4 BDNF CASP3 COMT DRD2
11 immune system MP:0005387 10.19 APOE AQP4 CASP3 COMT DRD2 GFAP
12 integument MP:0010771 10.13 APOE BDNF CASP3 DRD2 IGF1 IL10
13 hearing/vestibular/ear MP:0005377 10.01 APOE AQP4 BDNF CASP3 IGF1 MBP
14 muscle MP:0005369 9.98 APOE CASP3 DRD2 GFAP IGF1 IL10
15 normal MP:0002873 9.97 BDNF DRD2 GFAP IGF1 IL10 MBP
16 renal/urinary system MP:0005367 9.92 APOE AQP4 CASP3 COMT DRD2 IGF1
17 reproductive system MP:0005389 9.91 APOE BDNF CASP3 COMT DRD2 IGF1
18 respiratory system MP:0005388 9.9 APOE AQP4 BDNF CASP3 COMT DRD2
19 taste/olfaction MP:0005394 9.35 APOE BDNF CASP3 DRD2 ENO2
20 vision/eye MP:0005391 9.23 APOE AQP4 BDNF CASP3 GFAP IL10

Drugs & Therapeutics for Traumatic Brain Injury

Drugs for Traumatic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 467)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2
Cisatracurium Approved Phase 4 96946-41-7
3
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
4
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
5
Quinidine Approved, Investigational Phase 4 56-54-2 441074
6
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
7
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
8
Ethanol Approved Phase 4 64-17-5 702
9
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
10
Citalopram Approved Phase 4 59729-33-8 2771
11
Fosphenytoin Approved, Investigational Phase 4 93390-81-9 56339
12
Simvastatin Approved Phase 4 79902-63-9 54454
13
Sertraline Approved Phase 4 79617-96-2 68617
14
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
15
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
16
Phenylephrine Approved Phase 4 59-42-7 6041
17
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
18
Nicotine Approved Phase 4 54-11-5 942 89594
19
Mirtazapine Approved Phase 4 61337-67-5, 85650-52-8 4205
20
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
21
Haloperidol Approved Phase 4 52-86-8 3559
22
Ephedrine Approved Phase 4 299-42-3 9294
23
Pseudoephedrine Approved Phase 4 90-82-4 7028
24
Prazosin Approved Phase 4 19216-56-9 4893
25
Amantadine Approved Phase 4 768-94-5 2130
26
Sargramostim Approved, Investigational Phase 4 83869-56-1, 123774-72-1
27
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
28
Propranolol Approved, Investigational Phase 4 525-66-6 4946
29
Topiramate Approved Phase 4 97240-79-4 5284627
30
Levetiracetam Approved, Investigational Phase 4 102767-28-2 441341
31
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
32
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
33
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
34
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
35
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
36
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
37
Amitriptyline Approved Phase 4 50-48-6 2160
38
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
39
Sumatriptan Approved, Investigational Phase 4 103628-46-2 5358
40
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
41
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
42
Rizatriptan Approved Phase 4 144034-80-0, 145202-66-0 5078
43
Donepezil Approved Phase 4 120014-06-4 3152
44
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 441240 60857
45
Pramipexole Approved, Investigational Phase 4 104632-26-0 59868 119570
46
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
47
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
48
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
49
Memantine Approved, Investigational Phase 4 19982-08-2 4054
50
Racepinephrine Approved Phase 4 329-65-7 838

Interventional clinical trials:

(show top 50) (show all 1351)
# Name Status NCT ID Phase Drugs
1 Efficacy of Methylphenidate for Management of Long-Term Attention Problems After Pediatric Traumatic Brain Injury (TBI) Unknown status NCT01933217 Phase 4 Methylphenidate;Placebo
2 A Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin in Patients With Traumatic Brain Injury Unknown status NCT01606111 Phase 4 Cerebrolysin;0.9% NaCl, saline
3 Randomized Controlled Clinical Study of Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
4 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
5 Normothermia in Patients With Acute Cerebral Damage Unknown status NCT00491192 Phase 4 Diclofenac
6 A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
7 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents. A Controlled Randomized Study Versus Placebo Unknown status NCT02404779 Phase 4 cisatracurium besilate
8 Pilot Study: The Effect of Rozerem on Sleep Disturbance After Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
9 Effects of Intensive Insulin Therapy on Mortality, Morbidity and Long Term Neurologic Outcome in Neurosurgical Intensive Care Patients Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
10 A Randomised Control Trial to Determine the Effectiveness of Sensory Stimulation Program in Reducing the Length of Time Spent by Severely Brain Injured Patients in a Vegetative State in the Acute Hospital Environment Unknown status NCT00163878 Phase 4
11 Efficiency and Tolerance of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula in the Critically Ill Patient : a Prospective Randomized Trial Unknown status NCT01833624 Phase 4
12 Administration of Tranexamic Acid in the Preclinical Setting and Its Effect on Coagulation Parameters and Outcome in Multiple Trauma Patients and Isolated TBI in EMS (Schutz Und Rettung Zürich) and Helicopter Rescue(REGA). Unknown status NCT02354885 Phase 4 Tranexamic Acid
13 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
14 The Use of Low Molecular Weight Heparin in Traumatic Brain Injury Completed NCT00170378 Phase 4 Enoxaparin
15 A 26-Week Open-Label Extension to Protocol No. CENA713BUS11: A 12-Week, Prospective, Double-blind, Placebo-controlled, Multi-center Study Evaluating the Efficacy and Safety of Rivastigmine 3 to 6 mg/Day in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits Completed NCT00219245 Phase 4 Rivastigmine
16 Improvement of Therapy in Patients With Severe Traumatic Brain Injury: Differential Impact of Local and Systemic Changes and Routinely Applied Drugs Completed NCT02130674 Phase 4 Dipeptiven
17 Pharmacological Intervention in Depression After Traumatic Brain Injury (A Research Study Within the Traumatic Brain Injury Model System) Completed NCT00205491 Phase 4 Venlafaxine
18 Beta-Adrenergic Blockade for Suppression of Catecholamine Surge Following Traumatic Brain Injury: A Randomized Trial Completed NCT02957331 Phase 4 Propranolol
19 Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI Completed NCT01750268 Phase 4 Topiramate;Placebo
20 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Recombinant human growth hormone
21 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon: A Prospective Randomized Clinical Trial Injury to Reduce Sympathetic Storm Phenomenon: A Prospective Randomized Clinical Trial Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
22 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
23 Simvastatin: Proof-of-Concept for Prevention of Neurodegeneration in Mild TBI Completed NCT01952288 Phase 4 simvastatin;Placebo Oral Tablet
24 Assessment of Seizure Prophylaxis Protocols Using Intravenous Levetiracetam in a Neuroscience Intensive Care Unit Completed NCT00618436 Phase 4 Levetiracetam;Phenytoin
25 Amantadine Hydrochloride for Treatment of Symptoms of the Post-traumatic Confusional State Among Neurorehabilitation Admissions With TBI: A Randomized, Double-Blind, Placebo-Controlled Trial Completed NCT00693121 Phase 4 Amantadine hydrochloride;Placebo capsule
26 Phase IV Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury Completed NCT01339806 Phase 4
27 The Control of Brain Networks After Traumatic Brain Injury: a Neuroimaging and Neuropsychological Study of Dopamine and Cognition Completed NCT02015949 Phase 4 Methylphenidate;Placebo
28 The Serotonin Transporter Gene Polymorphism and Major Depression Following Traumatic Brain Injury Completed NCT00254007 Phase 4 citalopram (celexa)
29 Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery Completed NCT00035139 Phase 4 methylphenidate
30 Bispectral Index Value Changes During Induction and Surgical Decompression in Head Injury Patients Completed NCT03480880 Phase 4
31 Micronized Oral Progesterone and Effect on Time Symptomatic From Concussion: A Pilot Study Completed NCT01809639 Phase 4 Progesterone;Placebo
32 A Study to Assess the Safety, Tolerability and Effectiveness of Nuedexta (Dextromethorphan 20 mg/Quinidine 10 mg) in the Treatment of Pseudobulbar Affect (PBA) Completed NCT01799941 Phase 4 Nuedexta (DM 20 mg/Q 10 mg)
33 Equimolar Doses of Mannitol and Hypertonic Saline in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
34 Abobotulinumtoxina Efficacy in Post-Traumatic Headache Completed NCT03928496 Phase 4 AbobotulinumtoxinA;Normal saline
35 An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder Completed NCT02258828 Phase 4 Memantine
36 Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity Completed NCT00178646 Phase 4 Botox
37 Progesterone Augmentation of Nicotine Replacement Therapy Study Completed NCT02685072 Phase 4 Progesterone (200 mgs BID);Placebo
38 The Effect of Amantadine on Movement Disorder in Ataxia-Telangiectasia Completed NCT00950196 Phase 4 amantadine sulphate
39 Combined Mirtazapine and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment of Post-traumatic Stress Disorder (PTSD) Completed NCT01178671 Phase 4 Mirtazapine;Sertraline
40 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
41 Dexmedetomidine Addition to Benzodiazepines for Patients With Alcohol Withdrawal Syndrome in the ICU: a Randomised Controlled Study Completed NCT02496650 Phase 4 Dexmedetomidine
42 Randomized Controlled Trial of Intravenous Fluid In Severely Injured Paediatric Trauma Patients: Comparison of Normal Saline Versus Ringer's Lactate Completed NCT01692769 Phase 4 Normal Saline;Ringer's Lactate
43 Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors Completed NCT02713087 Phase 4 Ephedrine;Phenylephrine
44 A Multi-Center, Open Label Randomized Stratified Controlled Trial of the Effects of Blood Glucose Management on 90-Day All-Cause Mortality in a Heterogenous Population of Intensive Care Unit (ICU) Patients. Completed NCT00220987 Phase 4
45 A Study of Sertraline to Prevent PTSD Completed NCT00182078 Phase 4 Placebo;Sertraline
46 EFFICACY OF KETAMINE-PROPOFOL COMBINATION FOR SHORT SURGICAL PROCEDURES Completed NCT01651988 Phase 4 Ketamina-Propofol Combination
47 Cerebral Protection of Dexmedetomidine Against Paroxysmal Sympathetic Overexcited in Patients With Traumatic Brain Injury Recruiting NCT04006054 Phase 4 Dexmedetomidine;Midazolam
48 Effect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury Recruiting NCT02321761 Phase 4 Amantadine hydrochloride
49 Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates? Recruiting NCT03054285 Phase 4 Levetiracetam
50 Prazosin and CSF Biomarkers in mTBI Recruiting NCT03221751 Phase 4 prazosin hydrochloride;placebo

Search NIH Clinical Center for Traumatic Brain Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Traumatic Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Traumatic Brain Injury:
MultiStem, bone marrow-derived cells for neurological disorders
Embryonic/Adult Cultured Cells Related to Traumatic Brain Injury:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 23205020 20637752 23020860 21175285 21248119

Genetic Tests for Traumatic Brain Injury

Anatomical Context for Traumatic Brain Injury

MalaCards organs/tissues related to Traumatic Brain Injury:

41
Brain, Testes, Spinal Cord, Bone, Cortex, Eye, Pituitary
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Traumatic Brain Injury:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Traumatic Brain Injury

Articles related to Traumatic Brain Injury:

(show top 50) (show all 30001)
# Title Authors PMID Year
1
Acupuncture for hearing loss after traumatic brain injury: A protocol for systematic review of randomized controlled trial. 38 17
31348277 2019
2
Effect of auricular electroacupuncture combined with body acupuncture in improving the consciousness of patients after traumatic brain injury: Study protocol for a randomized controlled trial. 38 17
31348298 2019
3
Frequency of neuroimaging for pediatric minor brain injury is determined by the primary treating medical department. 17
31305419 2019
4
Sex-specific incident dementia in patients with central nervous system trauma. 38
31065582 2019
5
Reduced avoidance coping in male, but not in female rats, after mild traumatic brain injury: Implications for depression. 38
31278968 2019
6
Insult-induced aberrant hippocampal neurogenesis: Functional consequences and possible therapeutic strategies. 38
31199935 2019
7
Differences in pathological changes between two rat models of severe traumatic brain injury. 38
31169198 2019
8
Early Imaging Associated With Improved Survival in Older Patients With Mild Traumatic Brain Injuries. 38
31059948 2019
9
Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury. 38
31201986 2019
10
Human neural stem cell transplants to address multiple pathologies associated with traumatic brain injury. 38
31169178 2019
11
Collagen-chitosan scaffold impregnated with bone marrow mesenchymal stem cells for treatment of traumatic brain injury. 38
31169196 2019
12
Modeling sports-related mild traumatic brain injury in animals-A systematic review. 38
31135069 2019
13
Ionic and synaptic mechanisms of seizure generation and epileptogenesis. 38
31150792 2019
14
(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice. 38
31295555 2019
15
Combining white matter diffusion and geometry for tract-specific alignment and variability analysis. 38
31096057 2019
16
Predicting long-term cognitive and neuropathological consequences of moderate to severe traumatic brain injury: Review and theoretical framework. 38
31156042 2019
17
Decompressive craniectomy for severe traumatic brain injury in children: analysis of long-term neuropsychological impairment and review of the literature. 38
31264065 2019
18
Prehospital Versus Trauma Center Glasgow Coma Scale in Pediatric Traumatic Brain Injury Patients. 38
31022676 2019
19
Prediction of functional outcome and discharge destination in patients with traumatic brain injury after post-acute rehabilitation. 38
31033582 2019
20
Higher plasma C-type lectin-like receptor 2 concentrations for prediction of higher risk of 30-day mortality in isolated severe blunt traumatic brain injury. 38
31202718 2019
21
Decompressive Craniectomy in Children with Severe Traumatic Brain Injury: A Multicenter Retrospective Study and Literature Review. 38
31054345 2019
22
Poor prognostic factors in elderly patients aged 75 years old or older with mild traumatic brain injury. 38
31221574 2019
23
A retrospective study of the effect of fibrinogen levels during fresh frozen plasma transfusion in patients with traumatic brain injury. 38
31309303 2019
24
Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians' attitudes. 38
31012052 2019
25
Visual processing patterns of adults with traumatic brain injury when viewing image-based grids and visual scenes. 38
31257929 2019
26
Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study. 38
31089054 2019
27
Complex Feed-Forward and Feedback Mechanisms Underlie the Relationship Between Traumatic Brain Injury and the Gut-Microbiota-Brain Axis. 38
30335675 2019
28
Elevated expression of miR-302 cluster improves traumatic brain injury by inhibiting phosphorylation of connexin43 via ERK signaling. 38
31096001 2019
29
A Systematic Scoping Review of Work Interventions for Hospitalised Adults with an Acquired Neurological Impairment. 38
30515620 2019
30
Cerebral microbleed detection using Susceptibility Weighted Imaging and deep learning. 38
31121296 2019
31
Current Concepts in the Evaluation of the Pediatric Patient with Concussion. 38
31342314 2019
32
Histone Deacetylase Inhibitors: A Novel Strategy in Trauma and Sepsis. 38
30601405 2019
33
Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits. 38
31410165 2019
34
Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes. 38
31410183 2019
35
ERPs predict symptomatic distress and recovery in sub-acute mild traumatic brain injury. 38
31228481 2019
36
Downregulated lncRNA CRNDE contributes to the enhancement of nerve repair after traumatic brain injury in rats. 38
31345079 2019
37
Vision rehabilitation interventions following mild traumatic brain injury: a scoping review. 38
29631511 2019
38
Motivation in rehabilitation and acquired brain injury: can theory help us understand it? 38
29693464 2019
39
How do you treat traumatic brain injury? One symptom at a time. 38
31206780 2019
40
A systematic review of large animal models of combined traumatic brain injury and hemorrhagic shock. 38
31255665 2019
41
Fronto-temporal vulnerability to disconnection in paediatric moderate and severe traumatic brain injury. 38
30964589 2019
42
Breviscapine provides a neuroprotective effect after traumatic brain injury by modulating the Nrf2 signaling pathway. 38
31042302 2019
43
Gene expression profile of the hippocampus of rats subjected to traumatic brain injury. 38
31074048 2019
44
The Transition Trajectory for the Patient with a Traumatic Brain Injury. 38
31331627 2019
45
Letter to the Editor Regarding "Prediction of Early Intracranial Hypertension After Severe Traumatic Brain Injury: A Prospective Study". 38
31426262 2019
46
In Reply to the Letter to the Editor Regarding "Prediction of Early Intracranial Hypertension After Severe Traumatic Brain Injury: A Prospective Study". 38
31426263 2019
47
Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury: a CENTER-TBI analysis. 38
31240583 2019
48
From decompressive craniectomy to cranioplasty and beyond-a pediatric neurosurgery perspective. 38
31327037 2019
49
2-Carba cyclic phosphatidic acid inhibits lipopolysaccharide-induced prostaglandin E2 production in a human macrophage cell line. 38
31367683 2019
50
Monitoring traumatic brain injury in China. 38
31397282 2019

Variations for Traumatic Brain Injury

Expression for Traumatic Brain Injury

Search GEO for disease gene expression data for Traumatic Brain Injury.

Pathways for Traumatic Brain Injury

Pathways related to Traumatic Brain Injury according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 IL6 IL10 IGF1 GH1 CASP3 BDNF
2
Show member pathways
13.1 IL6 IGF1 GH1 CASP3 BDNF AQP4
3
Show member pathways
12.82 IL6 IGF1 GH1 CASP3 BDNF
4
Show member pathways
12.2 IL6 IL10 GH1 GFAP
5
Show member pathways
12.04 IL6 IL10 IGF1 GH1 BDNF
6 12.03 UCHL1 S100B MBP GFAP ENO2 COMT
7
Show member pathways
11.87 IL6 IL10 IGF1 GH1 BDNF
8 11.86 IL6 IL10 CASP3 BDNF AQP4
9 11.76 IL6 IGF1 ENO2
10 11.71 IL6 IL10 CASP3
11 11.57 IL6 IL10 CASP3
12 11.57 S100B IGF1 GFAP BDNF
13 11.55 IL6 IGF1 GH1 BDNF
14 11.47 IL6 IL10 IGF1 BDNF
15 11.38 UCHL1 IL6 CASP3
16 11.31 IL6 IGF1 APOE
17 11.18 MBP IL6 GFAP CASP3 BDNF AQP4
18 11.11 IL10 IGF1 DRD2 BDNF
19 10.78 IL6 IL10 IGF1 GH1 GFAP BDNF
20 10.71 CASP3 BDNF

GO Terms for Traumatic Brain Injury

Cellular components related to Traumatic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 SPTAN1 S100B IL6 IL10 IGF1 GH1
2 extracellular space GO:0005615 9.76 S100B IL6 IL10 IGF1 GH1 ENO2
3 neuronal cell body GO:0043025 9.1 UCHL1 S100B MBP ENO2 CASP3 APOE
4 myelin sheath GO:0043209 8.65 MBP

Biological processes related to Traumatic Brain Injury according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.73 IL10 DRD2 COMT CASP3
2 axonogenesis GO:0007409 9.54 UCHL1 S100B DRD2
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 IL6 IGF1 GH1
4 positive regulation of glial cell proliferation GO:0060252 9.49 IL6 GFAP
5 negative regulation of B cell proliferation GO:0030889 9.48 IL10 CASP3
6 dopamine metabolic process GO:0042417 9.46 DRD2 COMT
7 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.4 IGF1 GH1
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 IL6 IGF1 GH1
9 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.26 MBP IL10
10 response to inactivity GO:0014854 8.96 IL10 DRD2
11 response to glucocorticoid GO:0051384 8.92 S100B IL6 IL10 CASP3

Molecular functions related to Traumatic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.83 UCHL1 SPTAN1 S100B MBP IL6 IL10
2 tau protein binding GO:0048156 9.16 S100B APOE
3 growth factor activity GO:0008083 9.02 IL6 IL10 IGF1 GH1 BDNF

Sources for Traumatic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet