MCID: TRN004
MIFTS: 42

Trench Fever

Categories: Bone diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Trench Fever

MalaCards integrated aliases for Trench Fever:

Name: Trench Fever 12 60 3 3 45 15 17 74
Bartonellosis Due to Bartonella Quintana Infection 60
His-Werner Disease 12
Shin Bone Fever 12
Tibialgic Fever 12
Wolhynian Fever 12
Quintan Fever 12

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11101
ICD9CM 36 083.1
MeSH 45 D014205
SNOMED-CT 69 82214002
ICD10 34 A79.0
MESH via Orphanet 46 D014205
ICD10 via Orphanet 35 A79.0
UMLS via Orphanet 75 C0040830
Orphanet 60 ORPHA64694
UMLS 74 C0040830

Summaries for Trench Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in systemic infection, has material basis in Bartonella quintana, which is transmitted by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.

MalaCards based summary : Trench Fever, also known as bartonellosis due to bartonella quintana infection, is related to q fever and bartonellosis. An important gene associated with Trench Fever is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Activated TLR4 signalling. Affiliated tissues include testes and eye, and related phenotypes are hematopoietic system and immune system

CDC : 3 Bartonella bacteria cause several diseases in humans. The most common is cat scratch disease.

Wikipedia : 77 Trench fever (also known as "five-day fever", "quintan fever" (febris quintana in Latin), and "urban... more...

Related Diseases for Trench Fever

Diseases related to Trench Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 q fever 30.2 TLR1 TLR10 TLR2 TLR4
2 bartonellosis 11.5
3 pediculus humanus corporis infestation 11.2
4 epidemic typhus 10.4
5 variola major 10.3 TLR3 TLR4
6 prosthetic joint infection 10.3 TLR2 TLR4
7 fungal keratitis 10.2 TLR2 TLR4
8 neurosyphilis 10.2 TLR1 TLR2 TLR6
9 superficial basal cell carcinoma 10.2 TLR7 TLR8 TLR9
10 aspergillosis 10.2 TLR2 TLR4 TLR9
11 acute cervicitis 10.2 TLR2 TLR4
12 ocular toxoplasmosis 10.2 TLR1 TLR5 TLR9
13 bronchiolitis 10.2 TLR10 TLR4 TLR9
14 ileitis 10.2 TLR2 TLR4 TLR5
15 legionellosis 10.2 TLR2 TLR4 TLR5
16 toxoplasmosis 10.2 TLR2 TLR4 TLR9
17 urethritis 10.2 TLR1 TLR6
18 myositis fibrosa 10.2 TLR2 TLR4 TLR9
19 lyme disease 10.2 TLR1 TLR2 TLR6
20 bornholm eye disease 10.2
21 endocarditis 10.2
22 cat-scratch disease 10.2
23 relapsing fever 10.2
24 influenza 10.2
25 middle ear disease 10.2 TLR2 TLR4 TLR9
26 keratitis, hereditary 10.1 TLR2 TLR4 TLR9
27 juvenile nasopharyngeal angiofibroma 10.1 TLR3 TLR7 TLR9
28 primary bacterial infectious disease 10.1 TLR2 TLR4 TLR9
29 mucocutaneous leishmaniasis 10.1 TLR3 TLR9
30 dental abscess 10.1 KANTR TLR4
31 cutaneous leishmaniasis 10.1 TLR2 TLR4 TLR9
32 leishmaniasis 10.1 TLR2 TLR4 TLR9
33 visceral leishmaniasis 10.1 TLR2 TLR4 TLR9
34 mouth disease 10.1 TLR3 TLR4 TLR9
35 legionnaires' disease 10.1 TLR4 TLR5 TLR6 TLR9
36 penicilliosis 10.1 TLR1 TLR2 TLR4 TLR6
37 periodontitis 10.1 TLR2 TLR4 TLR9
38 pelvic inflammatory disease 10.1 TLR1 TLR2 TLR4 TLR6
39 endocervicitis 10.1 TLR4 TRIM33
40 oral cavity cancer 10.1 TLR2 TLR6 TLR9
41 suppurative otitis media 10.0 TLR2 TLR4 TLR5 TLR9
42 septic arthritis 10.0 TLR2 TLR4 TLR5 TLR9
43 mycobacterium tuberculosis 1 10.0 TLR1 TLR2 TLR4 TLR9
44 rectal disease 10.0 KANTR TLR7 TLR9
45 pneumonia 10.0 TLR2 TLR4 TLR5 TLR9
46 filarial elephantiasis 10.0 TLR2 TLR9
47 bacillary angiomatosis 10.0
48 dumping syndrome 10.0
49 viral infectious disease 10.0 TLR3 TLR7 TLR8 TLR9
50 myd88 deficiency 10.0 TLR1 TLR2 TLR4 TLR5 TLR6

Graphical network of the top 20 diseases related to Trench Fever:



Diseases related to Trench Fever

Symptoms & Phenotypes for Trench Fever

MGI Mouse Phenotypes related to Trench Fever:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 PGLYRP1 TLR1 TLR2 TLR3 TLR4 TLR5
2 immune system MP:0005387 9.36 PGLYRP1 TLR1 TLR2 TLR3 TLR4 TLR5

Drugs & Therapeutics for Trench Fever

Search Clinical Trials , NIH Clinical Center for Trench Fever

Cochrane evidence based reviews: trench fever

Genetic Tests for Trench Fever

Anatomical Context for Trench Fever

MalaCards organs/tissues related to Trench Fever:

42
Testes, Eye

Publications for Trench Fever

Articles related to Trench Fever:

(show top 50) (show all 54)
# Title Authors Year
1
The epidemic typhus and trench fever are risk for public health due to increased migration in southeast of Turkey. ( 29126839 )
2018
2
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. ( 27352876 )
2016
3
The centenary of the discovery of trench fever, an emerging infectious disease of World War 1. ( 27375211 )
2016
4
Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26000974 )
2015
5
Correction: Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26075401 )
2015
6
Trench fever: a relapsing fever occurring among the British troops in France and Salonica. ( 24845898 )
2014
7
Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever. ( 23517327 )
2013
8
The Peacock versus the louse (pediculus humanus corporis): one soldier's contribution to combating trench fever in the First World War. ( 20973437 )
2010
9
Urban trench fever presenting as culture-negative endocarditis. ( 18835881 )
2009
10
High Bartonella spp. seroprevalence in a Swedish homeless population but no evidence of trench fever. ( 17852922 )
2008
11
Trench fever: the British medical response in the Great War. ( 17082300 )
2006
12
Detection of Bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever. ( 15472378 )
2004
13
Urban trench fever and cat scratch disease. ( 12684929 )
2003
14
From trench fever to endocarditis. ( 14654579 )
2003
15
Urban trench fever in a healthy man from the southeastern United States. ( 12471587 )
2002
16
Bartonella quintana and urban trench fever. ( 10913410 )
2000
17
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. ( 10476755 )
1999
18
Outbreak of epidemic typhus associated with trench fever in Burundi. ( 9717922 )
1998
19
The expanding spectrum of Bartonella infections: I. Bartonellosis and trench fever. ( 9002093 )
1997
20
Trench fever among homeless people in Marseille, France: a seroprevalence survey. ( 9196653 )
1997
21
Bartonella species infections, including cat-scratch disease, trench fever, and bacillary angiomatosis--what molecular techniques have revealed. ( 8779201 )
1996
22
Q fever and trench fever. ( 8727131 )
1996
23
Has trench fever returned? ( 7529896 )
1995
24
Return of trench fever. ( 7853966 )
1995
25
Trench fever in Belfast, and the nature of the 'relapsing fevers' in the United Kingdom in the nineteenth century. ( 2672525 )
1989
26
Trench fever. A resumé of literature and a note on some obscure phases of the disease. ( 6432481 )
1984
27
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever. ( 6742814 )
1984
28
Enzyme immunoassay of antibody to Rochalimaea quintana: diagnosis of trench fever and serologic cross-reactions among other rickettsiae. ( 351072 )
1978
29
Vole agent identified as a strain of the trench fever rickettsia, Rochalimaea quintana. ( 417026 )
1978
30
A passive hemagglutination test for diagnosis of trench fever due to Rochalimaea quintana. ( 63526 )
1976
31
Trench fever. II. Propagation of Rickettsia quintana on cell-free medium from the blood of two patients. ( 5810798 )
1969
32
Trench fever. 3. Induction of clinical disease in volunteers inoculated with Rickettsia quintana propagated on blood agar. ( 5810799 )
1969
33
Metabolic Activity of the Trench Fever Rickettsia, Rickettsia quintana. ( 16562152 )
1967
34
In vitro cultivation of the rickettsial agent of trench fever. ( 5297000 )
1966
35
Studies on trench fever. I. Propagation of Rickettsia-like microorganisms from a patient's blood. ( 13781520 )
1961
36
[Relapses in typhus and trench fever]. ( 13223218 )
1954
37
Experimental infection of Macacus rhesus with Rickettsia quintana (trench fever). ( 13120859 )
1953
38
Trench Fever. ( 20784435 )
1942
39
Trench Fever: Final Report of the War Office Trench Fever Investigation Committee. ( 20474739 )
1921
40
Trench Fever: Its Epidemiology and Endemiology. ( 19981284 )
1920
41
The Association of Rickettsia with Trench Fever. ( 20474682 )
1919
42
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis. ( 20769352 )
1919
43
CHRONIC TRENCH FEVER. ( 20769505 )
1919
44
A CRITICISM OF CERTAIN RECENT CLAIMS TO HAVE DISCOVERED AND CULTIVATED THE FILTER-PASSING VIRUS OF TRENCH FEVER AND OF INFLUENZA. ( 20769587 )
1919
45
PRELIMINARY NOTE ON THE ASSOCIATION OF RICKETTSIA BODIES IN LICE WITH TRENCH FEVER. ( 20769186 )
1918
46
TRENCH FEVER. ( 20769271 )
1918
47
A CASE OF "TRENCH FEVER," CONTRACTED IN ENGLAND. ( 20768479 )
1917
48
NOTES ON SO-CALLED "TRENCH FEVER" AS SEEN IN ENGLAND. ( 20768481 )
1917
49
TRENCH FEVER AND ITS ALLIES. ( 20768629 )
1917
50
ON THE ETIOLOGY OF TRENCH FEVER: (A Preliminary Communication.). ( 20768764 )
1917

Variations for Trench Fever

Expression for Trench Fever

Search GEO for disease gene expression data for Trench Fever.

Pathways for Trench Fever

Pathways related to Trench Fever according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 PGLYRP1 TLR1 TLR10 TLR2 TLR3 TLR4
2
Show member pathways
13.53 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
3
Show member pathways
13.38 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
4
Show member pathways
13.2 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
5
Show member pathways
13.13 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
6
Show member pathways
12.72 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
7
Show member pathways
12.66 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
8 12.58 TLR1 TLR2 TLR3 TLR6 TLR7 TLR8
9
Show member pathways
12.44 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
10
Show member pathways
12.35 TLR1 TLR2 TLR4 TLR6
11
Show member pathways
12.28 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
12
Show member pathways
12.28 TLR1 TLR2 TLR4 TLR5 TLR6 TLR7
13 12.24 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
14
Show member pathways
12.23 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
15 12.21 TLR1 TLR2 TLR4 TLR6 TLR9
16 11.98 TLR2 TLR4 TLR6
17
Show member pathways
11.97 TLR1 TLR2 TLR4 TLR6
18
Show member pathways
11.95 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
19 11.58 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
20 11.51 TLR2 TLR4 TLR5
21 11.44 TLR2 TLR4 TLR9
22
Show member pathways
11.44 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5
23 11.01 TLR1 TLR2
24 10.99 TLR3 TLR4

GO Terms for Trench Fever

Cellular components related to Trench Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.8 TLR1 TLR2 TLR6 TLR7 TLR9
2 phagocytic vesicle membrane GO:0030670 9.5 TLR1 TLR2 TLR6
3 endosome membrane GO:0010008 9.35 TLR3 TLR4 TLR7 TLR8 TLR9
4 early phagosome GO:0032009 9.26 TLR7 TLR9
5 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR1 TLR2
6 endolysosome membrane GO:0036020 8.92 TLR3 TLR7 TLR8 TLR9
7 integral component of membrane GO:0016021 10.15 KANTR SYNJ2BP TLR1 TLR10 TLR2 TLR3

Biological processes related to Trench Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.98 TLR2 TLR3 TLR4 TLR7 TLR9
2 positive regulation of tumor necrosis factor production GO:0032760 9.97 DDT TLR2 TLR3 TLR4 TLR9
3 positive regulation of chemokine production GO:0032722 9.93 TLR2 TLR3 TLR4 TLR7 TLR9
4 positive regulation of interferon-beta production GO:0032728 9.92 TLR2 TLR3 TLR4 TLR9
5 response to virus GO:0009615 9.91 CCDC130 TLR3 TLR8
6 positive regulation of interleukin-12 production GO:0032735 9.91 TLR2 TLR3 TLR4 TLR9
7 positive regulation of interleukin-8 production GO:0032757 9.91 TLR2 TLR3 TLR4 TLR5 TLR7 TLR9
8 cellular response to interferon-gamma GO:0071346 9.9 TLR2 TLR3 TLR4
9 positive regulation of JNK cascade GO:0046330 9.9 TLR3 TLR4 TLR9
10 microglial cell activation GO:0001774 9.89 TLR2 TLR3 TLR6 TLR7 TLR8
11 I-kappaB phosphorylation GO:0007252 9.88 TLR2 TLR3 TLR4 TLR7 TLR9
12 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.87 TLR3 TLR7 TLR8 TLR9
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 TLR4 TLR5 TLR6
14 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.86 TLR4 TLR7 TLR8 TLR9
15 positive regulation of interleukin-10 production GO:0032733 9.83 TLR2 TLR4 TLR9
16 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.83 TLR3 TLR4 TLR6
17 positive regulation of interferon-alpha biosynthetic process GO:0045356 9.83 TLR3 TLR7 TLR8 TLR9
18 toll-like receptor 9 signaling pathway GO:0034162 9.82 TLR7 TLR8 TLR9
19 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.82 TLR2 TLR4 TLR9
20 cell activation GO:0001775 9.81 TLR1 TLR2 TLR6
21 positive regulation of toll-like receptor signaling pathway GO:0034123 9.81 TLR2 TLR3 TLR5 TLR9
22 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.81 TLR1 TLR10 TLR2 TLR4 TLR5 TLR6
23 positive regulation of interferon-beta biosynthetic process GO:0045359 9.8 TLR3 TLR4 TLR7 TLR8 TLR9
24 negative regulation of osteoclast differentiation GO:0045671 9.74 TLR3 TLR4
25 necroptotic process GO:0070266 9.74 TLR3 TLR4
26 activation of NF-kappaB-inducing kinase activity GO:0007250 9.74 TLR3 TLR6
27 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.74 TLR4 TLR6
28 positive regulation of macrophage activation GO:0043032 9.74 TLR4 TLR6
29 positive regulation of interleukin-8 secretion GO:2000484 9.73 TLR1 TLR2
30 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.73 TLR4 TLR6
31 response to molecule of bacterial origin GO:0002237 9.73 TLR2 TLR9
32 macrophage activation GO:0042116 9.73 TLR1 TLR4
33 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.72 TLR3 TLR4
34 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.72 TLR1 TLR4
35 cellular response to lipoteichoic acid GO:0071223 9.72 TLR2 TLR4
36 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.72 TLR4 TLR6
37 interleukin-1 beta secretion GO:0050702 9.71 TLR4 TLR6
38 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.71 TLR3 TLR4
39 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.71 TLR1 TLR6
40 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.71 TLR4 TLR6
41 positive regulation of interleukin-18 production GO:0032741 9.7 TLR2 TLR9
42 tumor necrosis factor production GO:0032640 9.7 TLR2 TLR9
43 cellular response to diacyl bacterial lipopeptide GO:0071726 9.69 TLR2 TLR6
44 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.69 TLR2 TLR6
45 cellular response to triacyl bacterial lipopeptide GO:0071727 9.68 TLR1 TLR2
46 nitric oxide metabolic process GO:0046209 9.68 TLR2 TLR6
47 positive regulation of oxidative stress-induced neuron death GO:1903223 9.68 TLR4 TLR6
48 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.68 TLR1 TLR2
49 detection of diacyl bacterial lipopeptide GO:0042496 9.67 TLR2 TLR6
50 detection of triacyl bacterial lipopeptide GO:0042495 9.67 TLR1 TLR2

Molecular functions related to Trench Fever according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.95 TLR1 TLR10 TLR2 TLR3 TLR4 TLR6
2 signaling receptor activity GO:0038023 9.63 TLR1 TLR2 TLR3 TLR4 TLR6 TLR8
3 double-stranded RNA binding GO:0003725 9.58 TLR3 TLR7 TLR8
4 peptidoglycan binding GO:0042834 9.49 PGLYRP1 TLR2
5 interleukin-1 receptor binding GO:0005149 9.46 TLR5 TLR9
6 siRNA binding GO:0035197 9.43 TLR7 TLR9
7 lipopeptide binding GO:0071723 9.43 TLR1 TLR2 TLR6
8 lipopolysaccharide receptor activity GO:0001875 9.37 TLR2 TLR4
9 Toll-like receptor 2 binding GO:0035663 9.32 TLR1 TLR6
10 transmembrane signaling receptor activity GO:0004888 9.28 TLR1 TLR10 TLR3 TLR4 TLR5 TLR6
11 signaling pattern recognition receptor activity GO:0008329 9.26 TLR2 TLR7 TLR8 TLR9

Sources for Trench Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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