MCID: TRN004
MIFTS: 40

Trench Fever

Categories: Bone diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Trench Fever

MalaCards integrated aliases for Trench Fever:

Name: Trench Fever 12 59 3 44 15 73
Bartonellosis Due to Bartonella Quintana Infection 59
His-Werner Disease 12
Shin Bone Fever 12
Tibialgic Fever 12
Wolhynian Fever 12
Quintan Fever 12

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11101
ICD10 33 A79.0
ICD9CM 35 083.1
MeSH 44 D014205
SNOMED-CT 68 82214002
Orphanet 59 ORPHA64694
MESH via Orphanet 45 D014205
UMLS via Orphanet 74 C0040830
ICD10 via Orphanet 34 A79.0
UMLS 73 C0040830

Summaries for Trench Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in systemic infection, has material basis in Bartonella quintana, which is transmitted by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.

MalaCards based summary : Trench Fever, also known as bartonellosis due to bartonella quintana infection, is related to q fever and bartonellosis. An important gene associated with Trench Fever is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Proteoglycans in cancer and Diseases associated with the TLR signaling cascade. Affiliated tissues include bone, testes and lung, and related phenotype is digestive/alimentary.

CDC : 3 Bartonella bacteria cause several diseases in humans. The most common is cat scratch disease.

Wikipedia : 76 Trench fever (also known as "five-day fever", "quintan fever" (febris quintana in Latin), and "urban... more...

Related Diseases for Trench Fever

Diseases related to Trench Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 q fever 30.2 TLR2 TLR4 TNF
2 bartonellosis 11.5
3 pediculus humanus corporis infestation 11.1
4 epidemic typhus 10.3
5 prosthetic joint infection 10.2 TLR2 TLR4
6 fungal keratitis 10.2 TLR2 TLR4
7 acute cervicitis 10.2 TLR2 TLR4
8 suppurative otitis media 10.2 TLR2 TLR4
9 myositis fibrosa 10.2 TLR2 TLR4
10 neisseria meningitidis infection 10.2 TLR2 TLR4
11 septic arthritis 10.2 TLR2 TLR4
12 endometrial disease 10.2 TLR4 TNF
13 periodontosis 10.2 TLR4 TNF
14 haemophilus influenzae 10.2 TLR2 TNF
15 congenital cytomegalovirus 10.2 TLR2 TNF
16 irak4 deficiency 10.2 TLR2 TLR4
17 myd88 deficiency 10.2 TLR2 TLR4
18 periapical periodontitis 10.2 TLR2 TNF
19 nontuberculous mycobacterial lung disease 10.2 TLR2 TNF
20 mycobacterium abscessus 10.2 TLR2 TNF
21 pelvic inflammatory disease 10.2 TLR2 TLR4
22 primary systemic mycosis 10.2 TLR2 TNF
23 mycoplasma pneumoniae pneumonia 10.2 TLR2 TNF
24 invasive aspergillosis 10.2 TLR2 TLR4
25 bacterial sepsis 10.2 TLR4 TNF
26 tuberculous meningitis 10.2 TLR2 TNF
27 perinatal necrotizing enterocolitis 10.2 TLR4 TNF
28 endocarditis 10.2
29 cat-scratch disease 10.2
30 relapsing fever 10.2
31 influenza 10.2
32 rosacea 10.2 TLR2 TNF
33 extrinsic cardiomyopathy 10.2 TLR4 TNF
34 idiopathic neutropenia 10.2 TLR4 TNF
35 aphthous stomatitis 10.2 TLR2 TNF
36 infective endocarditis 10.1 TLR2 TNF
37 dental abscess 10.1 KANTR TLR4
38 lepromatous leprosy 10.1 TLR2 TNF
39 pyelonephritis 10.1 TLR4 TNF
40 opportunistic mycosis 10.1 TLR2 TNF
41 testicular disease 10.1 TLR2 TNF
42 brucellosis 10.1 TLR4 TNF
43 keratitis, hereditary 10.1 TLR2 TLR4
44 leptospirosis 10.1 TLR2 TNF
45 newcastle disease 10.1 CCDC130 TNF
46 typhoid fever 10.1 TLR4 TNF
47 chronic salpingitis 10.1 KANTR TNF
48 parasitic protozoa infectious disease 10.1 TLR2 TNF
49 anterior uveitis 10.1 TLR2 TLR4 TNF
50 penicilliosis 10.1 TLR2 TLR4 TNF

Graphical network of the top 20 diseases related to Trench Fever:



Diseases related to Trench Fever

Symptoms & Phenotypes for Trench Fever

MGI Mouse Phenotypes related to Trench Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 PGLYRP1 TLR2 TLR4 TNF TRIM33

Drugs & Therapeutics for Trench Fever

Search Clinical Trials , NIH Clinical Center for Trench Fever

Cochrane evidence based reviews: trench fever

Genetic Tests for Trench Fever

Anatomical Context for Trench Fever

MalaCards organs/tissues related to Trench Fever:

41
Bone, Testes, Lung

Publications for Trench Fever

Articles related to Trench Fever:

(show top 50) (show all 54)
# Title Authors Year
1
The epidemic typhus and trench fever are risk for public health due to increased migration in southeast of Turkey. ( 29126839 )
2018
2
The centenary of the discovery of trench fever, an emerging infectious disease of World War 1. ( 27375211 )
2016
3
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. ( 27352876 )
2016
4
Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26000974 )
2015
5
Correction: Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26075401 )
2015
6
Trench fever: a relapsing fever occurring among the British troops in France and Salonica. ( 24845898 )
2014
7
Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever. ( 23517327 )
2013
8
The Peacock versus the louse (pediculus humanus corporis): one soldier's contribution to combating trench fever in the First World War. ( 20973437 )
2010
9
Urban trench fever presenting as culture-negative endocarditis. ( 18835881 )
2009
10
High Bartonella spp. seroprevalence in a Swedish homeless population but no evidence of trench fever. ( 17852922 )
2008
11
Trench fever: the British medical response in the Great War. ( 17082300 )
2006
12
Detection of Bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever. ( 15472378 )
2004
13
From trench fever to endocarditis. ( 14654579 )
2003
14
Urban trench fever and cat scratch disease. ( 12684929 )
2003
15
Urban trench fever in a healthy man from the southeastern United States. ( 12471587 )
2002
16
Bartonella quintana and urban trench fever. ( 10913410 )
2000
17
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. ( 10476755 )
1999
18
Outbreak of epidemic typhus associated with trench fever in Burundi. ( 9717922 )
1998
19
Trench fever among homeless people in Marseille, France: a seroprevalence survey. ( 9196653 )
1997
20
The expanding spectrum of Bartonella infections: I. Bartonellosis and trench fever. ( 9002093 )
1997
21
Bartonella species infections, including cat-scratch disease, trench fever, and bacillary angiomatosis--what molecular techniques have revealed. ( 8779201 )
1996
22
Q fever and trench fever. ( 8727131 )
1996
23
Return of trench fever. ( 7853966 )
1995
24
Has trench fever returned? ( 7529896 )
1995
25
Trench fever in Belfast, and the nature of the 'relapsing fevers' in the United Kingdom in the nineteenth century. ( 2672525 )
1989
26
Trench fever. A resumAc of literature and a note on some obscure phases of the disease. ( 6432481 )
1984
27
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever. ( 6742814 )
1984
28
Vole agent identified as a strain of the trench fever rickettsia, Rochalimaea quintana. ( 417026 )
1978
29
Enzyme immunoassay of antibody to Rochalimaea quintana: diagnosis of trench fever and serologic cross-reactions among other rickettsiae. ( 351072 )
1978
30
A passive hemagglutination test for diagnosis of trench fever due to Rochalimaea quintana. ( 63526 )
1976
31
Trench fever. 3. Induction of clinical disease in volunteers inoculated with Rickettsia quintana propagated on blood agar. ( 5810799 )
1969
32
Trench fever. II. Propagation of Rickettsia quintana on cell-free medium from the blood of two patients. ( 5810798 )
1969
33
Metabolic Activity of the Trench Fever Rickettsia, Rickettsia quintana. ( 16562152 )
1967
34
In vitro cultivation of the rickettsial agent of trench fever. ( 5297000 )
1966
35
Studies on trench fever. I. Propagation of Rickettsia-like microorganisms from a patient's blood. ( 13781520 )
1961
36
[Relapses in typhus and trench fever]. ( 13223218 )
1954
37
Experimental infection of Macacus rhesus with Rickettsia quintana (trench fever). ( 13120859 )
1953
38
Trench Fever. ( 20784435 )
1942
39
Trench Fever: Final Report of the War Office Trench Fever Investigation Committee. ( 20474739 )
1921
40
Trench Fever: Its Epidemiology and Endemiology. ( 19981284 )
1920
41
The Association of Rickettsia with Trench Fever. ( 20474682 )
1919
42
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis. ( 20769352 )
1919
43
CHRONIC TRENCH FEVER. ( 20769505 )
1919
44
A CRITICISM OF CERTAIN RECENT CLAIMS TO HAVE DISCOVERED AND CULTIVATED THE FILTER-PASSING VIRUS OF TRENCH FEVER AND OF INFLUENZA. ( 20769587 )
1919
45
PRELIMINARY NOTE ON THE ASSOCIATION OF RICKETTSIA BODIES IN LICE WITH TRENCH FEVER. ( 20769186 )
1918
46
TRENCH FEVER. ( 20769271 )
1918
47
TRENCH FEVER AND ITS ALLIES. ( 20768629 )
1917
48
A CASE OF "TRENCH FEVER," CONTRACTED IN ENGLAND. ( 20768479 )
1917
49
NOTES ON SO-CALLED "TRENCH FEVER" AS SEEN IN ENGLAND. ( 20768481 )
1917
50
ON THE ETIOLOGY OF TRENCH FEVER: (A Preliminary Communication.). ( 20768764 )
1917

Variations for Trench Fever

Expression for Trench Fever

Search GEO for disease gene expression data for Trench Fever.

Pathways for Trench Fever

Pathways related to Trench Fever according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1 12 TLR2 TLR4 TNF
2
Show member pathways
11.97 TLR2 TLR4 TNF
3
Show member pathways
11.94 TLR2 TLR4 TNF
4 11.91 TLR2 TLR4 TNF
5
Show member pathways
11.85 TLR2 TLR4 TNF
6 11.83 TLR2 TLR4 TNF
7
Show member pathways
11.69 TLR2 TLR4 TNF
8
Show member pathways
11.64 TLR2 TLR4 TNF
9 11.48 TLR2 TLR4 TNF
10 11.39 TLR2 TLR4 TNF
11 11.28 TLR4 TNF
12 11.08 TLR4 TNF
13 11.07 TLR2 TLR4 TNF
14 10.82 TLR2 TLR4 TNF
15 10.48 TLR2 TLR4 TNF

GO Terms for Trench Fever

Cellular components related to Trench Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.62 TLR2 TLR4

Biological processes related to Trench Fever according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.78 PGLYRP1 TLR4 TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 TLR2 TLR4 TNF
3 positive regulation of tumor necrosis factor production GO:0032760 9.63 TLR2 TLR4
4 positive regulation of interferon-gamma production GO:0032729 9.63 TLR4 TNF
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 TLR4 TNF
6 negative regulation of endothelial cell proliferation GO:0001937 9.62 SYNJ2BP TNF
7 toll-like receptor signaling pathway GO:0002224 9.61 TLR2 TLR4
8 defense response to Gram-positive bacterium GO:0050830 9.61 PGLYRP1 TLR2 TNF
9 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.6 TLR2 TLR4
10 negative regulation of interferon-gamma production GO:0032689 9.59 PGLYRP1 TLR4
11 negative regulation of interleukin-6 production GO:0032715 9.58 TLR4 TNF
12 positive regulation of interferon-beta production GO:0032728 9.58 TLR2 TLR4
13 positive regulation of inflammatory response GO:0050729 9.58 TLR2 TLR4 TNF
14 positive regulation of interleukin-12 production GO:0032735 9.57 TLR2 TLR4
15 positive regulation of interleukin-10 production GO:0032733 9.56 TLR2 TLR4
16 microglial cell activation GO:0001774 9.55 TLR2 TNF
17 positive regulation of interleukin-6 production GO:0032755 9.54 TLR2 TLR4 TNF
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.52 TLR2 TLR4
19 regulation of cytokine secretion GO:0050707 9.51 TLR2 TLR4
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.5 TLR2 TLR4 TNF
21 I-kappaB phosphorylation GO:0007252 9.49 TLR2 TLR4
22 cellular response to lipoteichoic acid GO:0071223 9.48 TLR2 TLR4
23 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.46 TLR4 TNF
24 lipopolysaccharide-mediated signaling pathway GO:0031663 9.33 TLR2 TLR4 TNF
25 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.26 TLR2 TLR4
26 positive regulation of interleukin-8 production GO:0032757 9.13 TLR2 TLR4 TNF
27 positive regulation of chemokine production GO:0032722 8.8 TLR2 TLR4 TNF

Molecular functions related to Trench Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
2 peptidoglycan binding GO:0042834 8.96 PGLYRP1 TLR2
3 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Trench Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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