MCID: TRN004
MIFTS: 43

Trench Fever

Categories: Infectious diseases, Rare diseases, Bone diseases

Aliases & Classifications for Trench Fever

MalaCards integrated aliases for Trench Fever:

Name: Trench Fever 12 59 3 44 15 73
Bartonellosis Due to Bartonella Quintana Infection 59
His-Werner Disease 12
Shin Bone Fever 12
Tibialgic Fever 12
Wolhynian Fever 12
Quintan Fever 12

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11101
ICD10 33 A79.0
ICD9CM 35 083.1
MeSH 44 D014205
SNOMED-CT 68 82214002
Orphanet 59 ORPHA64694
MESH via Orphanet 45 D014205
UMLS via Orphanet 74 C0040830
ICD10 via Orphanet 34 A79.0
UMLS 73 C0040830

Summaries for Trench Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in systemic infection, has material basis in Bartonella quintana, which is transmitted by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back.

MalaCards based summary : Trench Fever, also known as bartonellosis due to bartonella quintana infection, is related to q fever and cat-scratch disease, and has symptoms including relapsing fever, headache and shin pain. An important gene associated with Trench Fever is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are NF-KappaB Family Pathway and Th17 cell differentiation. Affiliated tissues include bone and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Bartonella bacteria cause several diseases in humans. The three most common are cat scratch disease, caused by B. henselae; trench fever, caused by B. quintana; and Carrión’s disease, caused by B. bacilliformis.

Wikipedia : 76 Trench fever (also known as \"five-day fever\", \"quintan fever\" (febris quintana in Latin), and... more...

Related Diseases for Trench Fever

Diseases related to Trench Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 q fever 29.8 CD40LG TLR2 TLR4 TNF
2 cat-scratch disease 11.3
3 bartonellosis 11.3
4 diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies 11.0
5 carrion's disease 11.0
6 pediculus humanus corporis infestation 11.0
7 prosthetic joint infection 10.8 TLR2 TLR4
8 acute cervicitis 10.8 TLR2 TLR4
9 myositis fibrosa 10.8 TLR2 TLR4
10 coccidioidomycosis 10.7 CD40LG TLR4
11 spondylarthropathy 10.7 TLR4 TNF
12 neisseria meningitidis infection 10.7 TLR2 TLR4
13 pyelitis 10.7 CD40LG TLR4
14 cystic echinococcosis 10.7 CD40LG TLR4
15 periodontosis 10.7 CD40LG TLR4
16 bacteriuria 10.7 CD40LG TLR4
17 septic arthritis 10.7 TLR2 TLR4
18 legionnaires' disease 10.7 CD40LG TLR4
19 haemophilus influenzae 10.7 TLR2 TNF
20 encephalitozoonosis 10.7 CD40LG TNF
21 nontuberculous mycobacterial lung disease 10.7 TLR2 TNF
22 rheumatoid lung disease 10.7 CD40LG TNF
23 miller fisher syndrome 10.7 CD40LG TNF
24 mycobacterium abscessus 10.7 TLR2 TNF
25 irak4 deficiency 10.6 TLR2 TLR4
26 central nervous system vasculitis 10.6 CD40LG TNF
27 myd88 deficiency 10.6 TLR2 TLR4
28 osteosclerotic myeloma 10.6 CD40LG TNF
29 jejunoileitis 10.6 CD40LG TNF
30 acute salpingitis 10.6 CD40LG TNF
31 monoclonal gammopathy of uncertain significance 10.6 CD40LG TNF
32 coccidiosis 10.6 CD40LG TNF
33 hemorrhagic fever 10.6 CD40LG TNF
34 pneumocystosis 10.6 CD40LG TNF
35 tuberculous meningitis 10.6 TLR2 TNF
36 streptococcal meningitis 10.6 CD40LG TNF
37 spinal cord disease 10.6 CD40LG TNF
38 rosacea 10.6 TLR2 TNF
39 pustulosis palmaris et plantaris 10.6 CD40LG TNF
40 panuveitis 10.6 CD40LG TNF
41 lichen disease 10.5 CD40LG TNF
42 phlebotomus fever 10.5 CCDC130 CD40LG
43 dental abscess 10.5 KANTR TLR4
44 perinatal necrotizing enterocolitis 10.5 TLR4 TNF
45 plasmodium vivax malaria 10.5 CD40LG TNF
46 hepatitis e 10.5 CD40LG TNF
47 progressive multifocal leukoencephalopathy 10.5 CD40LG TNF
48 cerebral arteritis 10.5 CD40LG KANTR
49 commensal bacterial infectious disease 10.5 CD40LG TNF
50 geniculate herpes zoster 10.5 CD40LG KANTR

Graphical network of the top 20 diseases related to Trench Fever:



Diseases related to Trench Fever

Symptoms & Phenotypes for Trench Fever

Symptoms:

12
  • relapsing fever
  • headache
  • shin pain
  • soreness of the muscles of the legs

GenomeRNAi Phenotypes related to Trench Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.62 TNF TRIM33 WDHD1 CD40LG PGLYRP1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.62 TNF TRIM33 WDHD1 CD40LG PGLYRP1

MGI Mouse Phenotypes related to Trench Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 PGLYRP1 TLR2 TLR4 TNF TRIM33

Drugs & Therapeutics for Trench Fever

Search Clinical Trials , NIH Clinical Center for Trench Fever

Cochrane evidence based reviews: trench fever

Genetic Tests for Trench Fever

Anatomical Context for Trench Fever

MalaCards organs/tissues related to Trench Fever:

41
Bone, Testes

Publications for Trench Fever

Articles related to Trench Fever:

(show top 50) (show all 51)
# Title Authors Year
1
The epidemic typhus and trench fever are risk for public health due to increased migration in southeast of Turkey. ( 29126839 )
2018
2
The centenary of the discovery of trench fever, an emerging infectious disease of World War 1. ( 27375211 )
2016
3
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. ( 27352876 )
2016
4
Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26000974 )
2015
5
Correction: Competence of Cimex lectularius Bed Bugs for the Transmission of Bartonella quintana, the Agent of Trench Fever. ( 26075401 )
2015
6
Trench fever: a relapsing fever occurring among the British troops in France and Salonica. ( 24845898 )
2014
7
Genetic diversity of Bartonella quintana in macaques suggests zoonotic origin of trench fever. ( 23517327 )
2013
8
The Peacock versus the louse (pediculus humanus corporis): one soldier's contribution to combating trench fever in the First World War. ( 20973437 )
2010
9
Urban trench fever presenting as culture-negative endocarditis. ( 18835881 )
2009
10
High Bartonella spp. seroprevalence in a Swedish homeless population but no evidence of trench fever. ( 17852922 )
2008
11
Trench fever: the British medical response in the Great War. ( 17082300 )
2006
12
Detection of Bartonella quintana by direct immunofluorescence examination of blood smears of a patient with acute trench fever. ( 15472378 )
2004
13
From trench fever to endocarditis. ( 14654579 )
2003
14
Urban trench fever and cat scratch disease. ( 12684929 )
2003
15
Urban trench fever in a healthy man from the southeastern United States. ( 12471587 )
2002
16
Bartonella quintana and urban trench fever. ( 10913410 )
2000
17
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. ( 10476755 )
1999
18
Outbreak of epidemic typhus associated with trench fever in Burundi. ( 9717922 )
1998
19
Trench fever among homeless people in Marseille, France: a seroprevalence survey. ( 9196653 )
1997
20
The expanding spectrum of Bartonella infections: I. Bartonellosis and trench fever. ( 9002093 )
1997
21
Bartonella species infections, including cat-scratch disease, trench fever, and bacillary angiomatosis--what molecular techniques have revealed. ( 8779201 )
1996
22
Q fever and trench fever. ( 8727131 )
1996
23
Return of trench fever. ( 7853966 )
1995
24
Has trench fever returned? ( 7529896 )
1995
25
Trench fever in Belfast, and the nature of the 'relapsing fevers' in the United Kingdom in the nineteenth century. ( 2672525 )
1989
26
Trench fever. A resumAc of literature and a note on some obscure phases of the disease. ( 6432481 )
1984
27
Antibiotic susceptibility patterns in Rochalimaea quintana, the agent of trench fever. ( 6742814 )
1984
28
Vole agent identified as a strain of the trench fever rickettsia, Rochalimaea quintana. ( 417026 )
1978
29
Enzyme immunoassay of antibody to Rochalimaea quintana: diagnosis of trench fever and serologic cross-reactions among other rickettsiae. ( 351072 )
1978
30
A passive hemagglutination test for diagnosis of trench fever due to Rochalimaea quintana. ( 63526 )
1976
31
Trench fever. 3. Induction of clinical disease in volunteers inoculated with Rickettsia quintana propagated on blood agar. ( 5810799 )
1969
32
Trench fever. II. Propagation of Rickettsia quintana on cell-free medium from the blood of two patients. ( 5810798 )
1969
33
Metabolic Activity of the Trench Fever Rickettsia, Rickettsia quintana. ( 16562152 )
1967
34
In vitro cultivation of the rickettsial agent of trench fever. ( 5297000 )
1966
35
Studies on trench fever. I. Propagation of Rickettsia-like microorganisms from a patient's blood. ( 13781520 )
1961
36
[Relapses in typhus and trench fever]. ( 13223218 )
1954
37
Experimental infection of Macacus rhesus with Rickettsia quintana (trench fever). ( 13120859 )
1953
38
Trench Fever. ( 20784435 )
1942
39
Trench Fever: Final Report of the War Office Trench Fever Investigation Committee. ( 20474739 )
1921
40
Trench Fever: Its Epidemiology and Endemiology. ( 19981284 )
1920
41
The Association of Rickettsia with Trench Fever. ( 20474682 )
1919
42
A CRITICISM OF CERTAIN RECENT CLAIMS TO HAVE DISCOVERED AND CULTIVATED THE FILTER-PASSING VIRUS OF TRENCH FEVER AND OF INFLUENZA. ( 20769587 )
1919
43
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis. ( 20769352 )
1919
44
PRELIMINARY NOTE ON THE ASSOCIATION OF RICKETTSIA BODIES IN LICE WITH TRENCH FEVER. ( 20769186 )
1918
45
TRENCH FEVER. ( 20769271 )
1918
46
TRENCH FEVER AND ITS ALLIES. ( 20768629 )
1917
47
A CASE OF "TRENCH FEVER," CONTRACTED IN ENGLAND. ( 20768479 )
1917
48
ON THE ETIOLOGY OF TRENCH FEVER: (A Preliminary Communication.). ( 20768764 )
1917
49
SOME NOTES ON TRENCH FEVER. ( 20768227 )
1916
50
TRENCH FEVER: THE FIELD VOLE A POSSIBLE ORIGIN. ( 20768293 )
1916

Variations for Trench Fever

Expression for Trench Fever

Search GEO for disease gene expression data for Trench Fever.

Pathways for Trench Fever

Pathways related to Trench Fever according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.38 CD40LG TLR2 TLR4 TNF
2
Show member pathways
12.17 TLR2 TLR4 TNF
3 12.03 TLR2 TLR4 TNF
4
Show member pathways
11.99 TLR2 TLR4 TNF
5
Show member pathways
11.97 TLR2 TLR4 TNF
6 11.94 TLR2 TLR4 TNF
7
Show member pathways
11.89 TLR2 TLR4 TNF
8 11.87 TLR2 TLR4 TNF
9
Show member pathways
11.79 CD40LG TLR2 TLR4 TNF
10
Show member pathways
11.73 CD40LG TLR2 TLR4 TNF
11 11.59 TLR2 TLR4 TNF
12 11.56 CD40LG TLR4 TNF
13 11.5 TLR2 TLR4 TNF
14 11.24 TLR2 TLR4 TNF
15 11.11 TLR4 TNF
16 11.11 TLR2 TLR4 TNF
17 11.06 CD40LG TLR4
18 10.61 CD40LG TLR2 TLR4 TNF

GO Terms for Trench Fever

Cellular components related to Trench Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 CD40LG TLR2 TLR4 TNF
2 intrinsic component of plasma membrane GO:0031226 8.62 TLR2 TLR4

Biological processes related to Trench Fever according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.87 CD40LG TLR2 TLR4 TNF
2 inflammatory response GO:0006954 9.85 CD40LG TLR2 TLR4 TNF
3 defense response to bacterium GO:0042742 9.78 PGLYRP1 TLR4 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.67 PGLYRP1 TLR2 TNF
5 positive regulation of interferon-gamma production GO:0032729 9.62 TLR4 TNF
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 TLR4 TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.62 CD40LG TLR2 TLR4 TNF
8 negative regulation of endothelial cell proliferation GO:0001937 9.61 SYNJ2BP TNF
9 positive regulation of interleukin-6 production GO:0032755 9.61 TLR2 TLR4 TNF
10 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.6 TLR2 TLR4
11 negative regulation of interleukin-6 production GO:0032715 9.59 TLR4 TNF
12 negative regulation of interferon-gamma production GO:0032689 9.58 PGLYRP1 TLR4
13 positive regulation of interferon-beta production GO:0032728 9.58 TLR2 TLR4
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.58 TLR2 TLR4 TNF
15 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.56 TLR2 TLR4
16 I-kappaB phosphorylation GO:0007252 9.54 TLR2 TLR4
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 TLR2 TLR4 TNF
18 regulation of cytokine secretion GO:0050707 9.52 TLR2 TLR4
19 cellular response to lipoteichoic acid GO:0071223 9.51 TLR2 TLR4
20 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.48 TLR4 TNF
21 regulation of immunoglobulin secretion GO:0051023 9.46 CD40LG TNF
22 positive regulation of interleukin-8 production GO:0032757 9.43 TLR2 TLR4 TNF
23 positive regulation of interleukin-12 production GO:0032735 9.33 CD40LG TLR2 TLR4
24 positive regulation of interleukin-10 production GO:0032733 9.13 CD40LG TLR2 TLR4
25 positive regulation of chemokine production GO:0032722 8.8 TLR2 TLR4 TNF

Molecular functions related to Trench Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.26 CD40LG TNF
2 lipopolysaccharide binding GO:0001530 9.16 TLR2 TLR4
3 peptidoglycan binding GO:0042834 8.96 PGLYRP1 TLR2
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Trench Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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