TRICY1
MCID: TRC069
MIFTS: 20

Trichilemmal Cyst 1 (TRICY1)

Aliases & Classifications for Trichilemmal Cyst 1

MalaCards integrated aliases for Trichilemmal Cyst 1:

Name: Trichilemmal Cyst 1 58 13 74
Tricholemmal Cyst 58
Pilar Tumor 74
Pilar Cyst 58
Tricy1 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
onset usually in adolescence


HPO:

33
trichilemmal cyst 1:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 58 609649
MedGen 43 C1864801
SNOMED-CT via HPO 70 199879009 263681008 95320005

Summaries for Trichilemmal Cyst 1

OMIM : 58 Trichilemmal cysts, also known as pilar cysts or tricholemmal cysts, are derived from the outer root sheath of the deeper parts of a hair follicle and consist of a well-keratinized epidermal wall surrounding semisolid hair keratin. They occur predominantly on the scalp, are easily enucleated, and appear as a firm, smooth, white-walled cyst without a punctum (McGavran and Binnington, 1966; Pinkus, 1969; Leppard and Sanderson, 1976). (609649)

MalaCards based summary : Trichilemmal Cyst 1, also known as tricholemmal cyst, is related to proliferating trichilemmal cyst and dowling-degos disease. An important gene associated with Trichilemmal Cyst 1 is TRICY1 (Trichilemmal Cyst 1). Affiliated tissues include skin, and related phenotype is abnormality of the skin.

Related Diseases for Trichilemmal Cyst 1

Diseases related to Trichilemmal Cyst 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 proliferating trichilemmal cyst 11.6
2 dowling-degos disease 11.3
3 cone-rod dystrophy and hearing loss 2 11.1
4 nail disorder, nonsyndromic congenital, 3 10.0
5 steatocystoma multiplex 10.0
6 dermatofibrosarcoma protuberans 10.0
7 cholesteatoma of middle ear 10.0
8 flotch syndrome 10.0
9 laryngocele 10.0
10 leukonychia totalis 10.0
11 preauricular sinus 10.0

Graphical network of the top 20 diseases related to Trichilemmal Cyst 1:



Diseases related to Trichilemmal Cyst 1

Symptoms & Phenotypes for Trichilemmal Cyst 1

Human phenotypes related to Trichilemmal Cyst 1:

33
# Description HPO Frequency HPO Source Accession
1 abnormality of the skin 33 HP:0000951

Symptoms via clinical synopsis from OMIM:

58
Skin Nails Hair Skin:
trichilemmal cysts
cyst occur most often on the scalp (89%)
cysts occur less commonly on any part of the body where hair grows
cysts may be solitary (30%)
cysts may be multiple (70%)
more
Skin Nails Hair Skin Histology:
cysts are lined by epidermal cells
cysts may contain degenerated keratin
cysts may become calcified

Clinical features from OMIM:

609649

Drugs & Therapeutics for Trichilemmal Cyst 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Excision Versus Punch Incision in the Treatment of Epidermal Cysts Completed NCT00165958 Phase 4

Search NIH Clinical Center for Trichilemmal Cyst 1

Genetic Tests for Trichilemmal Cyst 1

Anatomical Context for Trichilemmal Cyst 1

MalaCards organs/tissues related to Trichilemmal Cyst 1:

42
Skin

Publications for Trichilemmal Cyst 1

Articles related to Trichilemmal Cyst 1:

# Title Authors Year
1
An animal model of cutaneous cyst development enables the identification of three QTLs including the homologue of a human locus (TRICY1). ( 31039361 )
2019
2
Mapping of hereditary trichilemmal cyst (TRICY1) to chromosome 3p24-p21.2 and exclusion of beta-CATENIN and MLH1. ( 15637721 )
2005
3
Proliferating tricholemmal cyst should always be considered as a low-grade carcinoma. ( 9252767 )
1997
4
Proliferating tricholemmal cyst: a possible pitfall in cytological diagnosis. ( 8807257 )
1996

Variations for Trichilemmal Cyst 1

Expression for Trichilemmal Cyst 1

Search GEO for disease gene expression data for Trichilemmal Cyst 1.

Pathways for Trichilemmal Cyst 1

GO Terms for Trichilemmal Cyst 1

Sources for Trichilemmal Cyst 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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