TRICY1
MCID: TRC069
MIFTS: 19

Trichilemmal Cyst 1 (TRICY1)

Aliases & Classifications for Trichilemmal Cyst 1

MalaCards integrated aliases for Trichilemmal Cyst 1:

Name: Trichilemmal Cyst 1 57 13 70
Tricholemmal Cyst 57
Pilar Tumor 70
Pilar Cyst 57
Tricy1 57

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant

Miscellaneous:
onset usually in adolescence


HPO:

31
trichilemmal cyst 1:
Inheritance autosomal dominant inheritance


External Ids:

OMIM® 57 609649
MedGen 41 C1864801
SNOMED-CT via HPO 68 199879009 263681008 95320005
UMLS 70 C0345992 C1864801

Summaries for Trichilemmal Cyst 1

OMIM® : 57 Trichilemmal cysts, also known as pilar cysts or tricholemmal cysts, are derived from the outer root sheath of the deeper parts of a hair follicle and consist of a well-keratinized epidermal wall surrounding semisolid hair keratin. They occur predominantly on the scalp, are easily enucleated, and appear as a firm, smooth, white-walled cyst without a punctum (McGavran and Binnington, 1966; Pinkus, 1969; Leppard and Sanderson, 1976). (609649) (Updated 20-May-2021)

MalaCards based summary : Trichilemmal Cyst 1, also known as tricholemmal cyst, is related to proliferating trichilemmal cyst and epidermoid cysts. An important gene associated with Trichilemmal Cyst 1 is TRICY1 (Trichilemmal Cyst 1). Affiliated tissues include heart, tongue and skin, and related phenotype is abnormality of the skin.

Related Diseases for Trichilemmal Cyst 1

Diseases related to Trichilemmal Cyst 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 proliferating trichilemmal cyst 11.2
2 epidermoid cysts 9.9
3 steatocystoma multiplex 9.9
4 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
5 dermatofibrosarcoma protuberans 9.9
6 cholesteatoma of middle ear 9.9
7 arteriovenous malformation 9.9
8 lymphangioma 9.9
9 hidrocystoma 9.9
10 hidradenoma 9.9
11 laryngocele 9.9
12 preauricular sinus 9.9
13 rare lymphatic malformation 9.9

Graphical network of the top 20 diseases related to Trichilemmal Cyst 1:



Diseases related to Trichilemmal Cyst 1

Symptoms & Phenotypes for Trichilemmal Cyst 1

Human phenotypes related to Trichilemmal Cyst 1:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the skin 31 HP:0000951

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Skin Nails Hair Skin:
trichilemmal cysts
cyst occur most often on the scalp (89%)
cysts occur less commonly on any part of the body where hair grows
cysts may be solitary (30%)
cysts may be multiple (70%)
more
Skin Nails Hair Skin Histology:
cysts are lined by epidermal cells
cysts may contain degenerated keratin
cysts may become calcified

Clinical features from OMIM®:

609649 (Updated 20-May-2021)

Drugs & Therapeutics for Trichilemmal Cyst 1

Search Clinical Trials , NIH Clinical Center for Trichilemmal Cyst 1

Genetic Tests for Trichilemmal Cyst 1

Anatomical Context for Trichilemmal Cyst 1

MalaCards organs/tissues related to Trichilemmal Cyst 1:

40
Heart, Tongue, Skin

Publications for Trichilemmal Cyst 1

Articles related to Trichilemmal Cyst 1:

# Title Authors PMID Year
1
Mapping of hereditary trichilemmal cyst (TRICY1) to chromosome 3p24-p21.2 and exclusion of beta-CATENIN and MLH1. 57 61
15637721 2005
2
Hereditary trichilemmal cysts: a proposal for the assessment of diagnostic clinical criteria. 57
23061468 2013
3
Hereditary trichilemmal cysts. Hereditary pilar cysts. 57
862218 1977
4
The natural history of trichilemmal cysts. 57
1268052 1976
5
"Sebaceous cysts" are trichilemmal cysts. 57
4181052 1969
6
Keratinous cysts of the skin. Identification and differentiation of pilar cysts from epidermal cysts. 57
5920781 1966
7
An Animal Model of Cutaneous Cyst Development Enables the Identification of Three Quantitative Trait Loci, Including the Homologue of a Human Locus (TRICY1). 61
31039361 2019
8
["Windmill-plasty" for coverage of large defects of the scalp]. 61
9715383 1998

Variations for Trichilemmal Cyst 1

Expression for Trichilemmal Cyst 1

Search GEO for disease gene expression data for Trichilemmal Cyst 1.

Pathways for Trichilemmal Cyst 1

GO Terms for Trichilemmal Cyst 1

Sources for Trichilemmal Cyst 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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