Trichinosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Trichinellosis is a zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus Trichinella and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur.

MalaCards based summary: Trichinosis, also known as trichinellosis, is related to respiratory syncytial virus infectious disease and mastocytosis. An important gene associated with Trichinosis is ICOSLG (Inducible T Cell Costimulator Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, heart and eye, and related phenotypes are emg abnormality and periorbital edema

Orphanet: ⁵⁸ Trichinellosis is a zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus Trichinella and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur.

Disease Ontology: ¹¹ A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi. Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur.

CDC: ² Trichinellosis, also called trichinosis, is caused by eating raw or undercooked meat of animals infected with the larvae of a species of worm called Trichinella. Infection occurs commonly in certain wild carnivorous (meat-eating) animals such as bear or cougar, or omnivorous (meat and plant-eating) animals such as domestic pigs or wild boar.

Wikipedia: ⁷⁵ Trichinosis, also known as trichinellosis, is a parasitic disease caused by roundworms of the... more...

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Related Diseases for Trichinosis

Diseases related to Trichinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 810)

#	Related Disease	Score	Top Affiliating Genes
1	respiratory syncytial virus infectious disease	30.9	IL5 IL13
2	mastocytosis	30.9	IL4 IL3 IL13
3	cystic echinococcosis	30.8	IL4 IL10 CD4
4	cysticercosis	30.3	IL6 IL5 IL4 IL10 CD4
5	alveolar echinococcosis	30.2	IL5 IL4 IL10 CD4
6	enterobiasis	30.1	IL5 IL4
7	echinococcosis	30.1	TNF IL6 IL5 IL17A IL10
8	hypereosinophilic syndrome	30.1	IL9 IL5 IL4 IL3 IL13 IL10
9	henoch-schoenlein purpura	30.1	TNF IL6 ICOSLG CD4
10	pyomyositis	30.1	PIK3C2A CD4
11	myositis	30.0	TNF PIK3C2A IL6 IL17A ICOSLG
12	penicillin allergy	30.0	IL4 IL13 IL10
13	cavernous sinus thrombosis	30.0	POMC CD4
14	trichuriasis	30.0	TNF IL9 IL13 IL10
15	toxocariasis	29.9	IL6 IL5 IL4 IL13 IL10
16	mononeuritis multiplex	29.9	TNF IL5 CD4
17	inflammatory bowel disease 1	29.9	TNF IL6 IL17A IL10
18	actinomycosis	29.9	TNF IL10 CD4
19	angina pectoris	29.9	TNF PIK3C2A IL6
20	adult syndrome	29.9	TNF POMC IL6
21	meningoencephalitis	29.8	TNF IL6 IL10 CD4
22	pericardial effusion	29.8	TNF PIK3C2A IL6 CD4
23	hypothyroidism	29.8	TNF POMC PIK3C2A IL4 IL17A
24	giardiasis	29.8	IL17A IL10 CD4
25	osteomyelitis	29.8	TNF IL6 IL4 IL10
26	myocarditis	29.8	TNF PIK3C2A IL6 IL4 IL17A IL10
27	endomyocardial fibrosis	29.8	TNF IL5 IL4 IL10
28	enterocolitis	29.8	TNF IL6 IL10
29	ascaris lumbricoides infection	29.7	IL9 IL5 IL4 IL13 IL10 CD4
30	bowel dysfunction	29.7	TNF POMC IL6 IL10
31	bell's palsy	29.7	TNF IL6 CD4
32	facial paralysis	29.7	TNF IL6 CD4
33	paine syndrome	29.6	TNF POMC IL6 IL10
34	cholera	29.6	TNF IL6 IL5 IL4 IL10
35	neuritis	29.5	TNF IL6 IL4 IL10
36	trichomoniasis	29.5	TNF IL6 IL10 CD4
37	poliomyelitis	29.5	TNF IL6 IL10 CD4
38	irritable bowel syndrome	29.5	TNF POMC IL6 IL4 IL17A IL10
39	diarrhea	29.4	TNF IL6 IL5 IL3 IL13 IL10
40	schistosomiasis	29.4	TNF IL9 IL5 IL4 IL17A IL13
41	cholangitis	29.4	TNF IL6 IL17A IL10
42	acute myocardial infarction	29.4	TNF PIK3C2A IL6 IL10
43	lymphopenia	29.4	IL6 IL4 IL10 FOXP3
44	vasculitis	29.4	TNF IL6 IL17A IL10
45	aspergillosis	29.4	TNF IL6 IL5 IL4 IL10
46	taeniasis	29.4	TNF IL6 IL5 IL4 IL13 IL10
47	syphilis	29.3	TNF IL17A FOXP3 CD4
48	leptospirosis	29.3	TNF PIK3C2A IL6 IL4 IL10
49	exanthem	29.3	TNF PIK3C2A IL6 IL4 IL17A IL10
50	leptin deficiency or dysfunction	29.3	TNF POMC IL6 IL10 CD4

Graphical network of the top 20 diseases related to Trichinosis:

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Symptoms & Phenotypes for Trichinosis

Human phenotypes related to Trichinosis:

⁵⁸ ³⁰ (show all 43)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	emg abnormality ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0003457
2	periorbital edema ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100539
3	hyporeflexia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001265
4	nausea ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002018
5	conjunctival hyperemia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0030953
6	increased circulating ige level ³⁰	Frequent (33%)		HP:0003212
7	dysphagia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002015
8	irritability ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000737
9	ophthalmoplegia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000602
10	vertigo ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002321
11	conjunctivitis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000509
12	skin rash ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000988
13	memory impairment ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002354
14	trismus ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000211
15	lethargy ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001254
16	hemiparesis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001269
17	tinnitus ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000360
18	confusion ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001289
19	apathy ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000741
20	excessive daytime somnolence ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001262
21	ocular pain ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0200026
22	abnormality of the cerebrospinal fluid ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002921
23	limitation of neck motion ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0005986
24	diplopia ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000651
25	facial palsy ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0010628
26	meningitis ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001287
27	babinski sign ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0003487
28	encephalopathy ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0001298
29	retinal hemorrhage ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000573
30	aphasia ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002381
31	hemiplegia ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0002301
32	abnormality of the optic nerve ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000587
33	anisocoria ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0009916
34	central retinal artery occlusion ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0025342
35	abnormality of eye movement ⁵⁸		Occasional (29-5%)
36	muscle weakness ⁵⁸		Frequent (79-30%)
37	behavioral abnormality ⁵⁸		Occasional (29-5%)
38	reduced consciousness/confusion ⁵⁸		Occasional (29-5%)
39	abnormality of the cardiovascular system ⁵⁸		Occasional (29-5%)
40	edema ⁵⁸		Frequent (79-30%)
41	increased circulating total ige level ⁵⁸		Frequent (79-30%)
42	facial edema ⁵⁸		Frequent (79-30%)
43	abnormal uvea morphology ⁵⁸		Very rare (<4-1%)

MGI Mouse Phenotypes related to Trichinosis:

⁴⁵ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.38	CD4 FOXP3 GLG1 ICOSLG IL10 IL13
2	growth/size/body region	MP:0005378	10.27	CD4 FOXP3 GLG1 IL10 IL13 IL17A
3	immune system	MP:0005387	10.25	CCL11 CD4 FOXP3 GLG1 ICOSLG IL10
4	digestive/alimentary	MP:0005381	10.18	CD4 FOXP3 GLG1 IL10 IL13 IL17A
5	endocrine/exocrine gland	MP:0005379	10.13	CD4 FOXP3 IL10 IL13 IL17A IL3
6	no phenotypic analysis	MP:0003012	10.11	CD4 FOXP3 IL10 IL13 IL17A IL4
7	cellular	MP:0005384	10.11	CD4 FOXP3 GLG1 IL10 IL13 IL3
8	liver/biliary system	MP:0005370	10.1	FOXP3 IL10 IL17A IL4 IL5 IL6
9	hematopoietic system	MP:0005397	10.09	CCL11 CD4 FOXP3 GLG1 ICOSLG IL10
10	respiratory system	MP:0005388	10	CCL11 FOXP3 IL10 IL13 IL17A IL3
11	mortality/aging	MP:0010768	9.77	CD4 FOXP3 GLG1 IL10 IL13 IL17A
12	integument	MP:0010771	9.32	CD4 FOXP3 IL10 IL13 IL17A IL4

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Drugs & Therapeutics for Trichinosis

Search Clinical Trials, NIH Clinical Center for Trichinosis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Thiabendazole

Cochrane evidence based reviews: trichinellosis

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Genetic Tests for Trichinosis

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Anatomical Context for Trichinosis

Organs/tissues related to Trichinosis:

MalaCards : Skin, Heart, Eye, Bone Marrow, Small Intestine, Adrenal Cortex, Skeletal Muscle

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Publications for Trichinosis

Articles related to Trichinosis:

(show top 50) (show all 3433)

#	Title	Authors	PMID	Year
1	Effect of altered gut microbiota on visceral hypersensitivity of postinfectious irritable bowel syndrome mice. ⁶²	Cheng F...Du L	36165068	2022
2	Laboratory Features of Trichinellosis and Eosinophilia Threshold for Testing, Nunavik, Quebec, Canada, 2009-2019. ⁶²	Harrison LB...Yansouni CP	36418003	2022
3	Epidemiology of Trichinella infection in wild boar from Spain and its impact on human health during the period 2006-2019. ⁶²	Moral SM...Perez JM	35991947	2022
4	Trichinella surveillance program in wild birds, Emilia-Romagna (northern Italy), 2006-2021. First report of Trichinella pseudospiralis in western marsh harrier (Circus aeruginosus) in Italy. ⁶²	G R...M T	36213525	2022
5	Trichinella spiralis-derived extracellular vesicles induce a protective immunity against larval challenge in mice. ⁶²	Ashour DS...Zoghroban HS	36264282	2022
6	Trichinella britovi recombinant proteins produced in Pichia pastoris expression system for specific IgG antibody detection in the sera of mice and pigs infected with Trichinella spp. ⁶²	Grzelak S...Stachyra A	36179852	2022
7	Evaluation of indirect-ELISA using eluted antigens from Trichinella spiralis muscle larvae for diagnosis of swine trichinellosis. ⁶²	Supcharoengoon U...Adisakwattana P	35944581	2022
8	Two trichinellosis outbreaks in Serbia - challenging diagnosis due to a potential co-infection with Toxocara spp. ⁶²	Mitic I...Sofronic-Milosavljevic L	36330684	2022
9	Characterization of a novel pyruvate kinase from Trichinella spiralis and its participation in sugar metabolism, larval molting and development. ⁶²	Yue WW...Cui J	36315477	2022
10	Efficacy of an aerosol-resistant pepsin powder used in artificial digestion for the detection of Trichinella larvae in meat. ⁶²	Vasilev S...Vasilev D	36189624	2022
11	A secreted MIF homologue from Trichinella spiralis binds to and interacts with host monocytes. ⁶²	Huang S...Yang Y	35901919	2022
12	Trichinella spiralis nurse cell formation is regulated via CCR7+ dendritic cells. ⁶²	Park MK...Yu HS	35689825	2022
13	Pigs' management practices and exposure to Trichinella spp. in pigs and warthogs in the northern area of Senegal. ⁶²	N'da KM...Kungu J	36341070	2022
14	The genus Trichinella and its presence in wildlife worldwide: A review. ⁶²	Crisostomo-Jorquera V...Landaeta-Aqueveque C	35398980	2022
15	Hematological, biochemical, and serological parameters of experimentally infected rabbits with Trichinella nativa and Trichinella spiralis for early identification of trichinellosis. ⁶²	Akibekov OS...Gajimuradova AM	36341071	2022
16	Human trichinellosis in Southeast Asia, 2001-2021. ⁶²	Yera H...Caron Y	35875401	2022
17	Potential therapeutic effect of platelet-rich plasma and albendazole on the muscular phase of experimental Trichinella spiralis infection. ⁶²	Eissa FMA...Elmallawany MA	36159633	2022
18	Epidemiology of Trichinella in the Arctic and subarctic: A review. ⁶²	Oksanen A...Loginova O	35812081	2022
19	Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans. ⁶²	Piaggi S...Corti A	35732270	2022
20	Ultrastructural tegumental changes of Trichinella spiralis adult and larval stages after in vitro exposure to Allium sativum. ⁶²	Abou Hussien N...Ibrahim A	35752343	2022
21	Trichinella spiralis infection ameliorates the severity of Citrobacter rodentium-induced experimental colitis in mice. ⁶²	Xue Y...Wang CF	35523284	2022
22	Dynamic changes of macrophage activation in mice infected with Trichinella spiralis. ⁶²	Sun Q...Zhu X	35344812	2022
23	Egyptian propolis and selenium nanoparticles against murine trichinosis: a novel therapeutic insight. ⁶²	Sarhan MH...Farag TI	35856263	2022
24	Lentinula edodes extract increases goblet cell number and Muc2 expression in an intestinal inflammatory model of Trichinella spiralis infection. ⁶²	Lopez-Cauce B...Puerto M	35427820	2022
25	The International Trichinella Reference Centre database. Report on thirty-three years of activity and future perspectives. ⁶²	Marucci G...La Rosa G	35498549	2022
26	Epidemiological perspective associated with principal risk factors of Trichinella spiralis infection in pigs and humans in Egypt. ⁶²	Mohammed ES...Felefel W	35993072	2022
27	Serological testing for Trichinella infection in animals and man: Current status and opportunities for advancements. ⁶²	Gomez-Morales MA...Ludovisi A	35601880	2022
28	Modulation of lymphocyte subpopulations in the small intestine of mice treated with probiotic bacterial strains and infected with Trichinella spiralis. ⁶²	Dvoroznakova E...Revajova V	35304938	2022
29	Bevacizumab: A new take on therapy of muscle phase of Trichinella spiralis infection. ⁶²	Rayia DA...Soliman S	35300938	2022
30	Trichinella britovi outbreak in Piedmont, North-West Italy, 2019-2020: Clinical and epidemiological insights in the one health perspective. ⁶²	Stroffolini G...Calleri G	35276355	2022
31	Preexisting Trichinella spiralis infection attenuates the severity of Pseudomonas aeruginosa-induced pneumonia. ⁶²	Long SR...Cui J	35500031	2022
32	A Trichinella spiralis new born larvae-specific protein, Ts-NBL1, interacts with host's cell vimentin. ⁶²	Wang A...Vallee I	35320836	2022
33	Epidemiology of trichinellosis in the People's Republic of China during 2009-2020. ⁶²	Zhang XZ...Cui J	35231417	2022
34	Long lasting immunity in trichinellosis - insight from a small study group. ⁶²	Ilic N...Mitic I	35606907	2022
35	Trichinellosis in Serbia has become a rare event - one outbreak with pulmonary complications. ⁶²	Mitic I...Sofronic-Milosavljevic L	35481468	2022
36	The "starry night" (diffuse microcalcific myopathy) - thousands of muscle microcalcifications after 30 years of Trichinella infection detected by ultrasound. ⁶²	Fodor D...Micu MC	35437525	2022
37	EphrinB2/ephB2 activation facilitates colonic synaptic potentiation and plasticity contributing to long-term visceral hypersensitivity in irritable bowel syndrome. ⁶²	Zhang L...Hou X	35183555	2022
38	Seroprevalence and Associated Risk Factors of Trichinellosis and T. Solium Cysticercosis in Indigenous Pigs in Hoa Binh Province, Vietnam. ⁶²	Le TT...Unger F	35448832	2022
39	Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice. ⁶²	Hamed AMR...Abdeltawab MSA	35601760	2022
40	Evaluation of Semi-Nested PCR Compared with Indirect-ELISA to Diagnose Human Fasciolosis. ⁶²	Alizadeh G...Rokni MB	35865068	2022
41	Evaluation of Immunotropic Activity of Iridoid-Anthocyanin Extract of Honeysuckle Berries (Lonicera caerulea L.) in the Course of Experimental Trichinellosis in Mice. ⁶²	Piekarska J...Kucharska AZ	35335313	2022
42	Efficacy of Zingiber officinale and Cinnamomum zeylanicum extracts against experimental Trichinella spiralis infection. ⁶²	Salama MAM...Mostafa EM	35299906	2022
43	Phenotypic Changes of Trichinella Spiralis Treated By Commiphora Molmol,Lepidium Sativum, and Albendazole: in Vitro Study. ⁶²	Abuelenain GL...Awad SM	35601763	2022
44	Investigation of the effect of the calcium channel blocker, verapamil, on the parasite burden, inflammatory response and angiogenesis in experimental Trichinella spiralis infection in mice. ⁶²	Fadil KHA...Abdeltawab MSA	35146144	2022
45	Evaluation of the PrioCHECK™ Trichinella AAD kit to detect Trichinella spiralis, T. britovi, and T. pseudospiralis larvae in pork using the automated digestion method Trichomatic-35. ⁶²	Basso W...Frey CF	34481946	2022
46	Validation of the Magnetic Stirrer Method for the Detection of Trichinella Larvae in Muscle Samples Based on Proficiency Tests Results. ⁶²	Rozycki M...Cencek T	35206002	2022
47	Oral immunization with attenuated Salmonella encoding an elastase elicits protective immunity against Trichinella spiralis infection. ⁶²	Zhang XZ...Wang ZQ	34879232	2022
48	Trichinella spiralis-associated myocarditis mimicking acute myocardial infarction. ⁶²	Mohib O...Castro Rodriguez J	32627690	2022
49	Peptide of Trichinella spiralis Infective Larval Extract That Harnesses Growth of Human Hepatoma Cells. ⁶²	Ruenchit P...Chaicumpa W	35558100	2022
50	Development and Accuracy Evaluation of Lateral Flow Immunoassay for Rapid Diagnosis of Schistosomiasis Mekongi in Humans. ⁶²	Rodpai R...Maleewong W	34981973	2022

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Genes for Trichinosis

Genes related to Trichinosis (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	6.28	DISEASES inferred ¹⁴ ¹⁴
2	IL4	Interleukin 4	Protein Coding	6.25	DISEASES inferred ¹⁴
3	IL5	Interleukin 5	Protein Coding	6.14	DISEASES inferred ¹⁴
4	IL13	Interleukin 13	Protein Coding	5.88	DISEASES inferred ¹⁴
5	IL9	Interleukin 9	Protein Coding	5.83	DISEASES inferred ¹⁴
6	IL10	Interleukin 10	Protein Coding	5.7	DISEASES inferred ¹⁴
7	CD4	CD4 Molecule	Protein Coding	5.56	DISEASES inferred ¹⁴
8	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	5.41	DISEASES inferred ¹⁴
9	IL3	Interleukin 3	Protein Coding	5.24	DISEASES inferred ¹⁴
10	POMC	Proopiomelanocortin	Protein Coding	5.03	DISEASES inferred ¹⁴
11	TNF	Tumor Necrosis Factor	Protein Coding	4.95	DISEASES inferred ¹⁴
12	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	4.93	DISEASES inferred ¹⁴
13	IL17A	Interleukin 17A	Protein Coding	4.93	DISEASES inferred ¹⁴
14	FOXP3	Forkhead Box P3	Protein Coding	4.9	DISEASES inferred ¹⁴
15	GLG1	Golgi Glycoprotein 1	Protein Coding	4.82	DISEASES inferred ¹⁴
16	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	4.81	DISEASES inferred ¹⁴
17	IL6	Interleukin 6	Protein Coding	4.8	DISEASES inferred ¹⁴

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Variations for Trichinosis

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Expression for Trichinosis

Search GEO for disease gene expression data for Trichinosis.

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Pathways for Trichinosis

Pathways related to Trichinosis according to GeneCards Suite gene sharing:

(show all 47)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.98	TSLP TNF POMC IL9 IL6 IL5
2	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.86	TNF IL9 IL6 IL5 IL4 IL3
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.66	CCL11 CD4 IL10 IL13 IL17A IL3
4	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.58	CCL11 CD4 IL10 IL13 IL17A IL3
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.45	TNF IL9 IL6 IL5 IL4 IL3
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.34	TNF IL9 IL6 IL5 IL4 IL3
7	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.3	TSLP TNF POMC IL9 IL6 IL5
8	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.73	GLG1 IL10 IL13 IL17A IL3 IL4
9	NF-kappaB Signaling ³	12.63	TNF IL4 IL3 IL17A IL10 FOXP3
10	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.6	TNF IL6 IL17A IL10 CD4
11	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.39	TNF IL6 IL4 CCL11
12	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.25	TNF IL5 IL4 IL17A IL10 CD4
13	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.18	TNF IL6 IL13 IL10
14	Neuroinflammation and glutamatergic signaling ⁷⁴	12.18	TNF IL6 IL4 IL13 IL10
15	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.14	TNF IL6 IL5 IL4 IL3 IL10
16	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	12.03	CD4 IL10 IL17A IL6 TNF
17	Interleukin-4 and Interleukin-13 signaling ⁶⁶	12	CCL11 IL10 IL13 IL17A IL4 IL6
18	Allograft rejection ⁷⁴	11.97	FOXP3 IL10 IL13 IL17A IL4 IL5
19	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.92	IL6 IL4 IL17A CD4
20	Glucocorticoid receptor regulatory network ⁶¹	11.91	POMC IL6 IL5 IL4 IL13
21	Innate Lymphoid Cells Differentiation ⁶⁵	11.88	CD4 IL10 IL13 IL17A IL4 IL5
22	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.87	TNF IL6 IL4 IL10 ICOSLG
23	Th17 cell differentiation pathway ⁷⁴	11.85	IL6 IL4 IL17A FOXP3 CD4
24	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.84	IL6 IL17A FOXP3
25	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.83	TNF IL6 IL10 CD4
26	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.82	TNF IL5 IL4 IL3 FOXP3
27	Lung fibrosis ⁷⁴	11.82	TNF IL6 IL5 IL4 IL13 CCL11
28	AP-1 transcription factor network ⁶¹	11.79	IL6 IL5 IL4 IL10
29	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.75	TNF IL6 IL5 IL4 IL13 IL10
30	Acute viral myocarditis ⁷⁴	11.74	IL6 IL10 CD4
31	IL 10 signaling pathway ⁶⁷	11.74	TNF PIK3C2A IL6 IL10
32	IL4-mediated signaling events ⁶¹	11.73	IL5 IL4 IL10 CCL11
33	miRNAs involvement in the immune response in sepsis ⁷⁴	11.66	TNF IL6 IL10
34	THC Differentiation Pathway ⁶⁴	11.57	CD4 IL10 IL4 TNF
35	Interleukin-10 signaling ⁶⁶	11.53	TNF IL6 IL10
36	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.41	TNF IL10 FOXP3
37	IL-10 Pathway ⁶⁴	11.4	TNF IL6 IL10
38	OX40 Pathway ⁶⁴	11.37	IL9 IL5 IL4 IL13 IL10
39	Cytokines and inflammatory response ⁷⁴	11.32	CD4 IL10 IL13 IL3 IL4 IL5
40	Prostaglandin signaling ⁷⁴	11.29	TNF IL6 IL17A
41	Development and heterogeneity of the ILC family ⁷⁴	11.26	IL13 IL17A IL4 IL5 IL6 IL9
42	Th2 Differentiation ⁶⁵	11.22	CCL11 CD4 FOXP3 IL10 IL13 IL4
43	G-protein signaling_Rap2B regulation pathway ²²	11.11	TNF IL9 IL6 IL5 IL4 IL3
44	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.95	IL9 IL6 IL5 IL4 IL13
45	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.88	IL4 CD4
46	Immune infiltration in pancreatic cancer ⁷⁴	10.6	IL10 IL13 IL17A IL4 IL5 IL6
47	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.39	TNF IL6

Sources

GO Terms for Trichinosis

Cellular components related to Trichinosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.03	TSLP TNF POMC IL9 IL6 IL5
2	extracellular space	GO:0005615	9.7	CCL11 IL10 IL13 IL17A IL3 IL4

Biological processes related to Trichinosis according to GeneCards Suite gene sharing:

(show all 36)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of DNA-templated transcription	GO:0045893	10.47	CD4 FOXP3 IL10 IL4 IL5 IL6
2	positive regulation of cell population proliferation	GO:0008284	10.37	TSLP IL9 IL6 IL5 IL4 IL3
3	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.21	TNF IL6 IL5 IL10
4	signal transduction	GO:0007165	10.2	CCL11 CD4 ICOSLG IL10 IL13 IL3
5	positive regulation of interleukin-6 production	GO:0032755	10.16	TSLP TNF IL6 IL17A
6	inflammatory response	GO:0006954	10.16	TNF IL9 IL6 IL5 IL17A IL13
7	positive regulation of smooth muscle cell proliferation	GO:0048661	10.15	TNF IL6 IL13
8	response to lipopolysaccharide	GO:0032496	10.14	TNF IL13 IL10 FOXP3
9	negative regulation of inflammatory response	GO:0050728	10.14	IL4 IL13 IL10 FOXP3
10	response to activity	GO:0014823	10.13	TNF IL6 IL10
11	positive regulation of B cell proliferation	GO:0030890	10.13	IL5 IL4 IL13
12	positive regulation of chemokine production	GO:0032722	10.11	TSLP TNF IL6
13	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	10.11	IL6 IL5 IL3 CD4
14	negative regulation of endothelial cell apoptotic process	GO:2000352	10.07	IL10 IL13 IL4
15	response to radiation	GO:0009314	10.06	TNF FOXP3 CCL11
16	negative regulation of tumor necrosis factor production	GO:0032720	10.06	FOXP3 IL10 IL4 POMC
17	liver regeneration	GO:0097421	10.04	TNF IL6 IL10
18	defense response to Gram-negative bacterium	GO:0050829	10.04	TSLP IL6 IL17A CD4
19	T cell activation	GO:0042110	10.03	IL4 ICOSLG FOXP3 CD4
20	microglial cell activation	GO:0001774	10.02	IL13 IL4 TNF
21	positive regulation of cytokine production involved in inflammatory response	GO:1900017	10.01	IL17A IL6 TNF
22	positive regulation of interleukin-10 production	GO:0032733	10.01	TSLP IL6 IL4 IL13
23	negative regulation of neurogenesis	GO:0050768	10	TNF IL6 CCL11
24	type 2 immune response	GO:0042092	9.97	IL4 IL10
25	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	9.97	TNF IL6 IL5 IL10
26	vascular endothelial growth factor production	GO:0010573	9.96	TNF IL6
27	negative regulation of cytokine production involved in immune response	GO:0002719	9.95	IL10 TNF
28	positive regulation of mononuclear cell migration	GO:0071677	9.94	IL4 TNF
29	positive regulation of receptor signaling pathway via STAT	GO:1904894	9.94	IL6 TSLP
30	regulation of isotype switching	GO:0045191	9.92	IL4 IL10
31	positive regulation of immunoglobulin production	GO:0002639	9.92	IL10 IL13 IL5 IL6
32	negative regulation of chronic inflammatory response	GO:0002677	9.91	IL4 FOXP3
33	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.88	IL4 IL13
34	chronic inflammatory response to antigenic stimulus	GO:0002439	9.78	TNF IL10
35	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.73	TSLP TNF IL6 IL4 IL3 IL13
36	immune response	GO:0006955	9.55	TNF IL9 IL6 IL5 IL4 IL3

Molecular functions related to Trichinosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.73	IL9 IL6 IL5 IL4 IL3 IL10
2	cytokine activity	GO:0005125	9.64	TSLP TNF IL9 IL6 IL5 IL4
3	cytokine receptor binding	GO:0005126	9.33	IL9 IL4 IL13

Sources

Sources for Trichinosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: TRC023 MIFTS: 55	Trichinosis Categories: Infectious diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Trichinosis

Aliases & Classifications for Trichinosis

MalaCards integrated aliases for Trichinosis:

Characteristics:

Prevelance:

Age Of Onset:

Classifications:

External Ids:

Summaries for Trichinosis

Related Diseases for Trichinosis

Diseases related to Trichinosis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Trichinosis:

Symptoms & Phenotypes for Trichinosis

Human phenotypes related to Trichinosis:

MGI Mouse Phenotypes related to Trichinosis:

Drugs & Therapeutics for Trichinosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: trichinellosis

Genetic Tests for Trichinosis

Anatomical Context for Trichinosis

Organs/tissues related to Trichinosis:

Publications for Trichinosis

Articles related to Trichinosis:

Genes for Trichinosis

Genes related to Trichinosis (0 elite genes):

Variations for Trichinosis

Expression for Trichinosis

Pathways for Trichinosis

Pathways related to Trichinosis according to GeneCards Suite gene sharing:

GO Terms for Trichinosis

Cellular components related to Trichinosis according to GeneCards Suite gene sharing:

Biological processes related to Trichinosis according to GeneCards Suite gene sharing:

Molecular functions related to Trichinosis according to GeneCards Suite gene sharing:

Sources for Trichinosis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :