MCID: TRC023
MIFTS: 46

Trichinosis

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Trichinosis

MalaCards integrated aliases for Trichinosis:

Name: Trichinosis 12 76 53 59 3 15
Trichinellosis 53 59 3 44 73
Human Trichinellosis 53 73
Trichinella Spiralis Infection 12
Infection with Trichinella 53
Trichiniasis 53

Characteristics:

Orphanet epidemiological data:

59
trichinellosis
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:9784
ICD10 33 B75
ICD9CM 35 124
MeSH 44 D014235
NCIt 50 C85199
Orphanet 59 ORPHA863
MESH via Orphanet 45 D014235
ICD10 via Orphanet 34 B75
UMLS via Orphanet 74 C0040896

Summaries for Trichinosis

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 863Disease definitionTrichinellosis is a zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus Trichinella and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur.Visit the Orphanet disease page for more resources.

MalaCards based summary : Trichinosis, also known as trichinellosis, is related to echinococcosis and schistosomiasis. An important gene associated with Trichinosis is TMX3 (Thioredoxin Related Transmembrane Protein 3), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include testes, skin and eye, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi . Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur.

CDC : 3 Trichinellosis, also called trichinosis, is a disease that people can get by eating raw or undercooked meat from animals infected with the microscopic parasite Trichinella.

Wikipedia : 76 Trichinosis is a parasitic disease caused by roundworms of the Trichinella type. During the initial... more...

Related Diseases for Trichinosis

Diseases related to Trichinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 echinococcosis 29.3 CD40LG IL5
2 schistosomiasis 29.2 CD40LG IL4 IL5
3 virus associated hemophagocytic syndrome 10.7 IL4 PIK3C2A
4 apparent mineralocorticoid excess 10.6 PIK3C2A POMC
5 jak3-deficient severe combined immunodeficiency 10.6 IL4 IL9
6 cough variant asthma 10.5 IL4 IL5
7 egg allergy 10.5 IL4 IL5
8 inflammatory bowel disease 4 10.5 IL4 IL5
9 scleritis 10.5 IL4 IL5
10 intrinsic asthma 10.5 IL4 IL5
11 atopic keratoconjunctivitis 10.5 IL4 IL5
12 angiostrongyliasis 10.5 IL4 IL5
13 status asthmaticus 10.5 IL5 PIK3C2A
14 apple allergy 10.5 IL4 IL5
15 non-suppurative otitis media 10.5 IL4 IL5
16 latex allergy 10.4 IL4 IL5
17 cercarial dermatitis 10.4 IL4 IL5
18 gastrointestinal allergy 10.4 IL4 IL5
19 urinary schistosomiasis 10.4 IL4 IL5
20 chronic conjunctivitis 10.4 IL4 IL5
21 severe combined immunodeficiency, x-linked 10.4 IL4 IL9
22 eosinophilic gastritis 10.4 IL4 IL5
23 kimura disease 10.4 IL4 IL5
24 chronic tic disorder 10.4 IL4 IL5
25 folliculitis 10.4 IL4 IL5
26 vernal keratoconjunctivitis 10.4 IL4 IL5
27 toxic oil syndrome 10.4 IL4 IL5
28 trichostrongyloidiasis 10.4 CD40LG PIK3C2A
29 primary amebic meningoencephalitis 10.4 IL4 IL5
30 ornithosis 10.4 CD40LG PIK3C2A
31 cytokine deficiency 10.4 IL5 IL9
32 immunoglobulin a deficiency 1 10.4 CD40LG IL4
33 allergic bronchopulmonary aspergillosis 10.4 IL4 IL5
34 congenital hypogammaglobulinemia 10.4 CD40LG IL4
35 endocrine exophthalmos 10.4 CD40LG POMC
36 parasitic ichthyosporea infectious disease 10.4 CD40LG IL4
37 milk allergy 10.4 IL4 IL5
38 rhinosporidiosis 10.3 CD40LG IL4
39 post-vaccinal encephalitis 10.3 CD40LG POMC
40 immunodeficiency with hyper-igm, type 1 10.3 CD40LG IL4
41 pulmonary eosinophilia 10.3 IL4 IL5
42 paranasal sinus disease 10.3 IL4 IL5
43 buruli ulcer 10.3 CD40LG IL4
44 onchocerciasis 10.3 IL4 IL5
45 legionnaires' disease 10.3 CD40LG PIK3C2A
46 allergic conjunctivitis 10.3 IL4 IL5
47 primary systemic mycosis 10.3 CD40LG IL4
48 nasal cavity disease 10.3 IL4 IL5
49 coccidiosis 10.3 CD40LG IL4
50 lichen disease 10.3 CD40LG IL4

Graphical network of the top 20 diseases related to Trichinosis:



Diseases related to Trichinosis

Symptoms & Phenotypes for Trichinosis

GenomeRNAi Phenotypes related to Trichinosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 IL5 IL9 NUMBL PIK3C2A POMC

MGI Mouse Phenotypes related to Trichinosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.23 ARSI CD40LG IL4 IL5 IL9 NUMBL

Drugs & Therapeutics for Trichinosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
2 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Trichinosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: trichinellosis

Genetic Tests for Trichinosis

Anatomical Context for Trichinosis

MalaCards organs/tissues related to Trichinosis:

41
Testes, Skin, Eye, Lung, Heart, Tongue, Skeletal Muscle

Publications for Trichinosis

Articles related to Trichinosis:

(show top 50) (show all 502)
# Title Authors Year
1
The impact of anthelminthic therapeutics on serological and tissues apoptotic changes induced by experimental trichinosis. ( 29844628 )
2018
2
Ultrastructural preservation of tissues and their reaction to the infection with trichinella in the El Plomo mummy: Muscle fiber ultrastructure and trichinosis/mummy of the Cerro El Plomo. ( 28475269 )
2017
3
Serum IgE and IgG4 against muscle larva excretory-secretory products during the early and late phases of human trichinellosis. ( 28932905 )
2017
4
Quantitative Risk Assessment of Human Trichinellosis Caused by Consumption of Pork Meat Sausages in Argentina. ( 26227185 )
2016
5
Matrix metalloproteinase (MMP)-9: A realiable marker for inflammation in early human trichinellosis. ( 27117947 )
2016
6
Wild boars meat as a potential source of human trichinellosis in Poland: current data. ( 26204193 )
2015
7
Consumption of untested pork contributed to over two-thousand clinical cases of human trichinellosis in Romania. ( 25651698 )
2014
8
Acute renal failure associated with albendazole therapy in a patient with trichinosis. ( 24842347 )
2014
9
Trichinosis caused by ingestion of raw soft-shelled turtle meat in Korea. ( 23710091 )
2013
10
Evaluation of recombinant serine protease inhibitor from Trichinella spiralis for immunodiagnosis of swine trichinosis. ( 23431815 )
2012
11
An outbreak of trichinosis with molecular identification of Trichinella sp. in Vietnam. ( 23230332 )
2012
12
The fifth outbreak of trichinosis in Korea. ( 22355208 )
2011
13
Next-generation sequencing of the Trichinella murrelli mitochondrial genome allows comprehensive comparison of its divergence from the principal agent of human trichinellosis, Trichinella spiralis. ( 20946970 )
2011
14
Human trichinosis in remotes of Uttarakhand, India. ( 22569322 )
2010
15
Cardiac involvement in patients with trichinosis hospitalized in western Romania. ( 20618083 )
2010
16
Human trichinosis after consumption of soft-shelled turtles, Taiwan. ( 19961701 )
2009
17
Results of the follow-up of the former trichinosis patients from Brasov County--Romania. ( 19081195 )
2009
18
The effect of pest control on the incidence of trichinosis in Virovitica-Podravina County, Croatia. ( 18644676 )
2008
19
Food-borne parasitic zoonosis: distribution of trichinosis in Thailand. ( 18567073 )
2008
20
Canine trichinosis presenting with syncope and AV conduction disturbance. ( 17063722 )
2006
21
Trichinosis: epidemiology in Thailand. ( 17072975 )
2006
22
Experimental trichinosis: parasitological, electrophysiological and biochemical studies. ( 16927861 )
2006
23
Intercellular adhesion molecule-2 (ICAM-2) in experimental trichinosis. ( 16333907 )
2005
24
Case report: acquired progressive muscular hypertrophy and trichinosis. ( 15891144 )
2005
25
First record of human trichinosis in Chile associated with consumption of wild boar (Sus scrofa). ( 15867957 )
2005
26
A trichinosis outbreak caused by wild boar meat in Turkey. ( 15991835 )
2005
27
Microcalcifications of pectoral muscle in trichinosis. ( 15730467 )
2005
28
Images in clinical medicine. The chemosis of trichinosis. ( 15282356 )
2004
29
Application and assessment of a dipstick assay in the diagnosis of hydatidosis and trichinosis. ( 15103552 )
2004
30
Damage to cell DNA in the bone marrow and testes of mice with experimental trichinosis. ( 15665925 )
2004
31
Trichinosis of psoas muscle. ( 12723669 )
2003
32
A common-source outbreak of trichinosis from consumption of bear meat. ( 12762120 )
2003
33
Quiz case. Trichinosis associated muscular calcifications. ( 14680918 )
2003
34
Trichinosis of psoas muscle. ( 12186138 )
2002
35
The effect of changes in the gastric pH value on experimental trichinosis. ( 11775094 )
2001
36
The first host record of trichinosis in a red fox, Vulpes vulpes japonica, from Aomori Prefecture, northern Honshu, Japan. ( 11503914 )
2001
37
Hand rash in trichinosis. ( 11422173 )
2001
38
Detection of trichinosis using TSM immunosensor. ( 18968436 )
2001
39
Outbreak of trichinosis (trichiniasis)-contracted in London in 1879. ( 11123411 )
2001
40
Outbreak of suspected trichinosis among travelers returning from a neighboring island. ( 11003731 )
2000
41
Blinded, placebo-controlled trial of antiparasitic drugs for trichinosis myositis. ( 10882628 )
2000
42
The effect of antioxidant preparation (antox) on the course and efficacy of treatment of trichinosis. ( 10786041 )
2000
43
Low incidence of cardiac abnormalities in treated trichinosis: a prospective study of 62 patients from a single-source outbreak. ( 10403348 )
1999
44
Diagnosis of trichinosis by indirect fluorescent antibody test with Trichinella larva section. ( 12563812 )
1999
45
Trichinosis outbreak after ingestion of barbecued badger. ( 10575152 )
1999
46
Role of anti-Trichinella spiralis antibodies and interferon-gamma in the protection against the enteral phase of experimental trichinosis. ( 9914684 )
1998
47
Evaluation of ELISA, IFAT and trichinoscopy in experimental trichinosis: comparing larval antigens prepared from rat and pig muscles. ( 9914705 )
1998
48
Trichinellosis (trichinosis) is caused by the aphasmid nematode, Trichinella spiralis. ( 9578092 )
1998
49
Concurrent trichinosis and oral squamous cell carcinoma in a cat. ( 9576356 )
1998
50
Serum beta 2-microglobulin in patients with trichinosis. ( 9581489 )
1997

Variations for Trichinosis

Expression for Trichinosis

Search GEO for disease gene expression data for Trichinosis.

Pathways for Trichinosis

Pathways related to Trichinosis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 CD40LG IL4 IL5 IL9 POMC
2
Show member pathways
12.57 CD40LG IL4 IL5 IL9
3
Show member pathways
12.31 IL4 IL5 IL9
4
Show member pathways
12.08 CD40LG IL4 IL5 IL9
5 11.55 IL4 IL5 POMC
6 11.51 IL4 IL5 IL9
7
Show member pathways
11.46 CD40LG IL4 IL5
8 11.3 CD40LG IL4 IL5
9 11.1 IL4 IL5 IL9
10 10.97 CD40LG IL4
11 10.95 IL4 IL5
12 10.85 CD40LG IL4 IL5
13 10.64 IL4 IL5 IL9
14 10.21 IL4 IL5 IL9

GO Terms for Trichinosis

Cellular components related to Trichinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 ARSI CD40LG IL4 IL5 IL9 POMC

Biological processes related to Trichinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.46 CD40LG IL4 IL5 IL9
2 positive regulation of B cell proliferation GO:0030890 9.26 IL4 IL5
3 cytokine-mediated signaling pathway GO:0019221 9.26 IL4 IL5 NUMBL POMC
4 regulation of signaling receptor activity GO:0010469 9.02 CD40LG IL4 IL5 IL9 POMC

Molecular functions related to Trichinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IL4 IL9
2 growth factor activity GO:0008083 9.13 IL4 IL5 IL9
3 cytokine activity GO:0005125 8.92 CD40LG IL4 IL5 IL9

Sources for Trichinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....