MCID: TRC023
MIFTS: 55

Trichinosis

Categories: Infectious diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Trichinosis

MalaCards integrated aliases for Trichinosis:

Name: Trichinosis 11 19 58 75 2 14 16 33
Trichinellosis 19 58 75 2 43 71 31 33
Human Trichinellosis 19 71
Trichiniasis 19 33
Trichinella Spiralis Infestation 33
Trichinella Spiralis Infection 11
Infection with Trichinella 19
Trichinelliasis 33

Characteristics:


Prevelance:

Trichinellosis: <1/1000000 (Europe, Croatia, Estonia, Italy, Slovakia) 1-9/1000000 (Bulgaria, Lithuania, Romania) 1-9/100000 (Latvia) 58

Age Of Onset:

Trichinellosis: All ages 58

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare infectious diseases


Summaries for Trichinosis

GARD: 19 Trichinellosis is a zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus Trichinella and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur.

MalaCards based summary: Trichinosis, also known as trichinellosis, is related to respiratory syncytial virus infectious disease and mastocytosis. An important gene associated with Trichinosis is ICOSLG (Inducible T Cell Costimulator Ligand), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, heart and eye, and related phenotypes are emg abnormality and periorbital edema

Orphanet: 58 Trichinellosis is a zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus Trichinella and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur.

Disease Ontology: 11 A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi. Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur.

CDC: 2 Trichinellosis, also called trichinosis, is caused by eating raw or undercooked meat of animals infected with the larvae of a species of worm called Trichinella. Infection occurs commonly in certain wild carnivorous (meat-eating) animals such as bear or cougar, or omnivorous (meat and plant-eating) animals such as domestic pigs or wild boar.

Wikipedia: 75 Trichinosis, also known as trichinellosis, is a parasitic disease caused by roundworms of the... more...

Related Diseases for Trichinosis

Diseases related to Trichinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 810)
# Related Disease Score Top Affiliating Genes
1 respiratory syncytial virus infectious disease 30.9 IL5 IL13
2 mastocytosis 30.9 IL4 IL3 IL13
3 cystic echinococcosis 30.8 IL4 IL10 CD4
4 cysticercosis 30.3 IL6 IL5 IL4 IL10 CD4
5 alveolar echinococcosis 30.2 IL5 IL4 IL10 CD4
6 enterobiasis 30.1 IL5 IL4
7 echinococcosis 30.1 TNF IL6 IL5 IL17A IL10
8 hypereosinophilic syndrome 30.1 IL9 IL5 IL4 IL3 IL13 IL10
9 henoch-schoenlein purpura 30.1 TNF IL6 ICOSLG CD4
10 pyomyositis 30.1 PIK3C2A CD4
11 myositis 30.0 TNF PIK3C2A IL6 IL17A ICOSLG
12 penicillin allergy 30.0 IL4 IL13 IL10
13 cavernous sinus thrombosis 30.0 POMC CD4
14 trichuriasis 30.0 TNF IL9 IL13 IL10
15 toxocariasis 29.9 IL6 IL5 IL4 IL13 IL10
16 mononeuritis multiplex 29.9 TNF IL5 CD4
17 inflammatory bowel disease 1 29.9 TNF IL6 IL17A IL10
18 actinomycosis 29.9 TNF IL10 CD4
19 angina pectoris 29.9 TNF PIK3C2A IL6
20 adult syndrome 29.9 TNF POMC IL6
21 meningoencephalitis 29.8 TNF IL6 IL10 CD4
22 pericardial effusion 29.8 TNF PIK3C2A IL6 CD4
23 hypothyroidism 29.8 TNF POMC PIK3C2A IL4 IL17A
24 giardiasis 29.8 IL17A IL10 CD4
25 osteomyelitis 29.8 TNF IL6 IL4 IL10
26 myocarditis 29.8 TNF PIK3C2A IL6 IL4 IL17A IL10
27 endomyocardial fibrosis 29.8 TNF IL5 IL4 IL10
28 enterocolitis 29.8 TNF IL6 IL10
29 ascaris lumbricoides infection 29.7 IL9 IL5 IL4 IL13 IL10 CD4
30 bowel dysfunction 29.7 TNF POMC IL6 IL10
31 bell's palsy 29.7 TNF IL6 CD4
32 facial paralysis 29.7 TNF IL6 CD4
33 paine syndrome 29.6 TNF POMC IL6 IL10
34 cholera 29.6 TNF IL6 IL5 IL4 IL10
35 neuritis 29.5 TNF IL6 IL4 IL10
36 trichomoniasis 29.5 TNF IL6 IL10 CD4
37 poliomyelitis 29.5 TNF IL6 IL10 CD4
38 irritable bowel syndrome 29.5 TNF POMC IL6 IL4 IL17A IL10
39 diarrhea 29.4 TNF IL6 IL5 IL3 IL13 IL10
40 schistosomiasis 29.4 TNF IL9 IL5 IL4 IL17A IL13
41 cholangitis 29.4 TNF IL6 IL17A IL10
42 acute myocardial infarction 29.4 TNF PIK3C2A IL6 IL10
43 lymphopenia 29.4 IL6 IL4 IL10 FOXP3
44 vasculitis 29.4 TNF IL6 IL17A IL10
45 aspergillosis 29.4 TNF IL6 IL5 IL4 IL10
46 taeniasis 29.4 TNF IL6 IL5 IL4 IL13 IL10
47 syphilis 29.3 TNF IL17A FOXP3 CD4
48 leptospirosis 29.3 TNF PIK3C2A IL6 IL4 IL10
49 exanthem 29.3 TNF PIK3C2A IL6 IL4 IL17A IL10
50 leptin deficiency or dysfunction 29.3 TNF POMC IL6 IL10 CD4

Graphical network of the top 20 diseases related to Trichinosis:



Diseases related to Trichinosis

Symptoms & Phenotypes for Trichinosis

Human phenotypes related to Trichinosis:

58 30 (show all 43)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 emg abnormality 58 30 Frequent (33%) Frequent (79-30%)
HP:0003457
2 periorbital edema 58 30 Frequent (33%) Frequent (79-30%)
HP:0100539
3 hyporeflexia 58 30 Frequent (33%) Frequent (79-30%)
HP:0001265
4 nausea 58 30 Frequent (33%) Frequent (79-30%)
HP:0002018
5 conjunctival hyperemia 58 30 Frequent (33%) Frequent (79-30%)
HP:0030953
6 increased circulating ige level 30 Frequent (33%) HP:0003212
7 dysphagia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002015
8 irritability 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000737
9 ophthalmoplegia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000602
10 vertigo 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002321
11 conjunctivitis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000509
12 skin rash 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000988
13 memory impairment 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002354
14 trismus 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000211
15 lethargy 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001254
16 hemiparesis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001269
17 tinnitus 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000360
18 confusion 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001289
19 apathy 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000741
20 excessive daytime somnolence 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001262
21 ocular pain 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0200026
22 abnormality of the cerebrospinal fluid 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002921
23 limitation of neck motion 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0005986
24 diplopia 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000651
25 facial palsy 58 30 Very rare (1%) Very rare (<4-1%)
HP:0010628
26 meningitis 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001287
27 babinski sign 58 30 Very rare (1%) Very rare (<4-1%)
HP:0003487
28 encephalopathy 58 30 Very rare (1%) Very rare (<4-1%)
HP:0001298
29 retinal hemorrhage 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000573
30 aphasia 58 30 Very rare (1%) Very rare (<4-1%)
HP:0002381
31 hemiplegia 58 30 Very rare (1%) Very rare (<4-1%)
HP:0002301
32 abnormality of the optic nerve 58 30 Very rare (1%) Very rare (<4-1%)
HP:0000587
33 anisocoria 58 30 Very rare (1%) Very rare (<4-1%)
HP:0009916
34 central retinal artery occlusion 58 30 Very rare (1%) Very rare (<4-1%)
HP:0025342
35 abnormality of eye movement 58 Occasional (29-5%)
36 muscle weakness 58 Frequent (79-30%)
37 behavioral abnormality 58 Occasional (29-5%)
38 reduced consciousness/confusion 58 Occasional (29-5%)
39 abnormality of the cardiovascular system 58 Occasional (29-5%)
40 edema 58 Frequent (79-30%)
41 increased circulating total ige level 58 Frequent (79-30%)
42 facial edema 58 Frequent (79-30%)
43 abnormal uvea morphology 58 Very rare (<4-1%)

MGI Mouse Phenotypes related to Trichinosis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.38 CD4 FOXP3 GLG1 ICOSLG IL10 IL13
2 growth/size/body region MP:0005378 10.27 CD4 FOXP3 GLG1 IL10 IL13 IL17A
3 immune system MP:0005387 10.25 CCL11 CD4 FOXP3 GLG1 ICOSLG IL10
4 digestive/alimentary MP:0005381 10.18 CD4 FOXP3 GLG1 IL10 IL13 IL17A
5 endocrine/exocrine gland MP:0005379 10.13 CD4 FOXP3 IL10 IL13 IL17A IL3
6 no phenotypic analysis MP:0003012 10.11 CD4 FOXP3 IL10 IL13 IL17A IL4
7 cellular MP:0005384 10.11 CD4 FOXP3 GLG1 IL10 IL13 IL3
8 liver/biliary system MP:0005370 10.1 FOXP3 IL10 IL17A IL4 IL5 IL6
9 hematopoietic system MP:0005397 10.09 CCL11 CD4 FOXP3 GLG1 ICOSLG IL10
10 respiratory system MP:0005388 10 CCL11 FOXP3 IL10 IL13 IL17A IL3
11 mortality/aging MP:0010768 9.77 CD4 FOXP3 GLG1 IL10 IL13 IL17A
12 integument MP:0010771 9.32 CD4 FOXP3 IL10 IL13 IL17A IL4

Drugs & Therapeutics for Trichinosis

Search Clinical Trials, NIH Clinical Center for Trichinosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Thiabendazole

Cochrane evidence based reviews: trichinellosis

Genetic Tests for Trichinosis

Anatomical Context for Trichinosis

Organs/tissues related to Trichinosis:

MalaCards : Skin, Heart, Eye, Bone Marrow, Small Intestine, Adrenal Cortex, Skeletal Muscle

Publications for Trichinosis

Articles related to Trichinosis:

(show top 50) (show all 3433)
# Title Authors PMID Year
1
Effect of altered gut microbiota on visceral hypersensitivity of postinfectious irritable bowel syndrome mice. 62
36165068 2022
2
Laboratory Features of Trichinellosis and Eosinophilia Threshold for Testing, Nunavik, Quebec, Canada, 2009-2019. 62
36418003 2022
3
Epidemiology of Trichinella infection in wild boar from Spain and its impact on human health during the period 2006-2019. 62
35991947 2022
4
Trichinella surveillance program in wild birds, Emilia-Romagna (northern Italy), 2006-2021. First report of Trichinella pseudospiralis in western marsh harrier (Circus aeruginosus) in Italy. 62
36213525 2022
5
Trichinella spiralis-derived extracellular vesicles induce a protective immunity against larval challenge in mice. 62
36264282 2022
6
Trichinella britovi recombinant proteins produced in Pichia pastoris expression system for specific IgG antibody detection in the sera of mice and pigs infected with Trichinella spp. 62
36179852 2022
7
Evaluation of indirect-ELISA using eluted antigens from Trichinella spiralis muscle larvae for diagnosis of swine trichinellosis. 62
35944581 2022
8
Two trichinellosis outbreaks in Serbia - challenging diagnosis due to a potential co-infection with Toxocara spp. 62
36330684 2022
9
Characterization of a novel pyruvate kinase from Trichinella spiralis and its participation in sugar metabolism, larval molting and development. 62
36315477 2022
10
Efficacy of an aerosol-resistant pepsin powder used in artificial digestion for the detection of Trichinella larvae in meat. 62
36189624 2022
11
A secreted MIF homologue from Trichinella spiralis binds to and interacts with host monocytes. 62
35901919 2022
12
Trichinella spiralis nurse cell formation is regulated via CCR7+ dendritic cells. 62
35689825 2022
13
Pigs' management practices and exposure to Trichinella spp. in pigs and warthogs in the northern area of Senegal. 62
36341070 2022
14
The genus Trichinella and its presence in wildlife worldwide: A review. 62
35398980 2022
15
Hematological, biochemical, and serological parameters of experimentally infected rabbits with Trichinella nativa and Trichinella spiralis for early identification of trichinellosis. 62
36341071 2022
16
Human trichinellosis in Southeast Asia, 2001-2021. 62
35875401 2022
17
Potential therapeutic effect of platelet-rich plasma and albendazole on the muscular phase of experimental Trichinella spiralis infection. 62
36159633 2022
18
Epidemiology of Trichinella in the Arctic and subarctic: A review. 62
35812081 2022
19
Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans. 62
35732270 2022
20
Ultrastructural tegumental changes of Trichinella spiralis adult and larval stages after in vitro exposure to Allium sativum. 62
35752343 2022
21
Trichinella spiralis infection ameliorates the severity of Citrobacter rodentium-induced experimental colitis in mice. 62
35523284 2022
22
Dynamic changes of macrophage activation in mice infected with Trichinella spiralis. 62
35344812 2022
23
Egyptian propolis and selenium nanoparticles against murine trichinosis: a novel therapeutic insight. 62
35856263 2022
24
Lentinula edodes extract increases goblet cell number and Muc2 expression in an intestinal inflammatory model of Trichinella spiralis infection. 62
35427820 2022
25
The International Trichinella Reference Centre database. Report on thirty-three years of activity and future perspectives. 62
35498549 2022
26
Epidemiological perspective associated with principal risk factors of Trichinella spiralis infection in pigs and humans in Egypt. 62
35993072 2022
27
Serological testing for Trichinella infection in animals and man: Current status and opportunities for advancements. 62
35601880 2022
28
Modulation of lymphocyte subpopulations in the small intestine of mice treated with probiotic bacterial strains and infected with Trichinella spiralis. 62
35304938 2022
29
Bevacizumab: A new take on therapy of muscle phase of Trichinella spiralis infection. 62
35300938 2022
30
Trichinella britovi outbreak in Piedmont, North-West Italy, 2019-2020: Clinical and epidemiological insights in the one health perspective. 62
35276355 2022
31
Preexisting Trichinella spiralis infection attenuates the severity of Pseudomonas aeruginosa-induced pneumonia. 62
35500031 2022
32
A Trichinella spiralis new born larvae-specific protein, Ts-NBL1, interacts with host's cell vimentin. 62
35320836 2022
33
Epidemiology of trichinellosis in the People's Republic of China during 2009-2020. 62
35231417 2022
34
Long lasting immunity in trichinellosis - insight from a small study group. 62
35606907 2022
35
Trichinellosis in Serbia has become a rare event - one outbreak with pulmonary complications. 62
35481468 2022
36
The "starry night" (diffuse microcalcific myopathy) - thousands of muscle microcalcifications after 30 years of Trichinella infection detected by ultrasound. 62
35437525 2022
37
EphrinB2/ephB2 activation facilitates colonic synaptic potentiation and plasticity contributing to long-term visceral hypersensitivity in irritable bowel syndrome. 62
35183555 2022
38
Seroprevalence and Associated Risk Factors of Trichinellosis and T. Solium Cysticercosis in Indigenous Pigs in Hoa Binh Province, Vietnam. 62
35448832 2022
39
Investigation of The Effect of Curcumin on Oxidative Stress, Local Inflammatory Response, COX-2 Expression, and Microvessel Density in Trichinella Spiralis Induced Enteritis, Myositis and Myocarditis in Mice. 62
35601760 2022
40
Evaluation of Semi-Nested PCR Compared with Indirect-ELISA to Diagnose Human Fasciolosis. 62
35865068 2022
41
Evaluation of Immunotropic Activity of Iridoid-Anthocyanin Extract of Honeysuckle Berries (Lonicera caerulea L.) in the Course of Experimental Trichinellosis in Mice. 62
35335313 2022
42
Efficacy of Zingiber officinale and Cinnamomum zeylanicum extracts against experimental Trichinella spiralis infection. 62
35299906 2022
43
Phenotypic Changes of Trichinella Spiralis Treated By Commiphora Molmol,Lepidium Sativum, and Albendazole: in Vitro Study. 62
35601763 2022
44
Investigation of the effect of the calcium channel blocker, verapamil, on the parasite burden, inflammatory response and angiogenesis in experimental Trichinella spiralis infection in mice. 62
35146144 2022
45
Evaluation of the PrioCHECKā„¢ Trichinella AAD kit to detect Trichinella spiralis, T. britovi, and T. pseudospiralis larvae in pork using the automated digestion method Trichomatic-35. 62
34481946 2022
46
Validation of the Magnetic Stirrer Method for the Detection of Trichinella Larvae in Muscle Samples Based on Proficiency Tests Results. 62
35206002 2022
47
Oral immunization with attenuated Salmonella encoding an elastase elicits protective immunity against Trichinella spiralis infection. 62
34879232 2022
48
Trichinella spiralis-associated myocarditis mimicking acute myocardial infarction. 62
32627690 2022
49
Peptide of Trichinella spiralis Infective Larval Extract That Harnesses Growth of Human Hepatoma Cells. 62
35558100 2022
50
Development and Accuracy Evaluation of Lateral Flow Immunoassay for Rapid Diagnosis of Schistosomiasis Mekongi in Humans. 62
34981973 2022

Variations for Trichinosis

Expression for Trichinosis

Search GEO for disease gene expression data for Trichinosis.

Pathways for Trichinosis

Pathways related to Trichinosis according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 TSLP TNF POMC IL9 IL6 IL5
2
Show member pathways
13.86 TNF IL9 IL6 IL5 IL4 IL3
3
Show member pathways
13.66 CCL11 CD4 IL10 IL13 IL17A IL3
4
Show member pathways
13.58 CCL11 CD4 IL10 IL13 IL17A IL3
5
Show member pathways
13.45 TNF IL9 IL6 IL5 IL4 IL3
6
Show member pathways
13.34 TNF IL9 IL6 IL5 IL4 IL3
7
Show member pathways
13.3 TSLP TNF POMC IL9 IL6 IL5
8
Show member pathways
12.73 GLG1 IL10 IL13 IL17A IL3 IL4
9 12.63 TNF IL4 IL3 IL17A IL10 FOXP3
10
Show member pathways
12.6 TNF IL6 IL17A IL10 CD4
11
Show member pathways
12.39 TNF IL6 IL4 CCL11
12
Show member pathways
12.25 TNF IL5 IL4 IL17A IL10 CD4
13 12.18 TNF IL6 IL13 IL10
14 12.18 TNF IL6 IL4 IL13 IL10
15 12.14 TNF IL6 IL5 IL4 IL3 IL10
16
Show member pathways
12.03 CD4 IL10 IL17A IL6 TNF
17 12 CCL11 IL10 IL13 IL17A IL4 IL6
18 11.97 FOXP3 IL10 IL13 IL17A IL4 IL5
19
Show member pathways
11.92 IL6 IL4 IL17A CD4
20 11.91 POMC IL6 IL5 IL4 IL13
21 11.88 CD4 IL10 IL13 IL17A IL4 IL5
22 11.87 TNF IL6 IL4 IL10 ICOSLG
23 11.85 IL6 IL4 IL17A FOXP3 CD4
24
Show member pathways
11.84 IL6 IL17A FOXP3
25 11.83 TNF IL6 IL10 CD4
26
Show member pathways
11.82 TNF IL5 IL4 IL3 FOXP3
27 11.82 TNF IL6 IL5 IL4 IL13 CCL11
28 11.79 IL6 IL5 IL4 IL10
29
Show member pathways
11.75 TNF IL6 IL5 IL4 IL13 IL10
30 11.74 IL6 IL10 CD4
31 11.74 TNF PIK3C2A IL6 IL10
32 11.73 IL5 IL4 IL10 CCL11
33 11.66 TNF IL6 IL10
34 11.57 CD4 IL10 IL4 TNF
35 11.53 TNF IL6 IL10
36
Show member pathways
11.41 TNF IL10 FOXP3
37 11.4 TNF IL6 IL10
38 11.37 IL9 IL5 IL4 IL13 IL10
39 11.32 CD4 IL10 IL13 IL3 IL4 IL5
40 11.29 TNF IL6 IL17A
41 11.26 IL13 IL17A IL4 IL5 IL6 IL9
42 11.22 CCL11 CD4 FOXP3 IL10 IL13 IL4
43 11.11 TNF IL9 IL6 IL5 IL4 IL3
44 10.95 IL9 IL6 IL5 IL4 IL13
45 10.88 IL4 CD4
46 10.6 IL10 IL13 IL17A IL4 IL5 IL6
47
Show member pathways
10.39 TNF IL6

GO Terms for Trichinosis

Cellular components related to Trichinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 TSLP TNF POMC IL9 IL6 IL5
2 extracellular space GO:0005615 9.7 CCL11 IL10 IL13 IL17A IL3 IL4

Biological processes related to Trichinosis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-templated transcription GO:0045893 10.47 CD4 FOXP3 IL10 IL4 IL5 IL6
2 positive regulation of cell population proliferation GO:0008284 10.37 TSLP IL9 IL6 IL5 IL4 IL3
3 positive regulation of DNA-binding transcription factor activity GO:0051091 10.21 TNF IL6 IL5 IL10
4 signal transduction GO:0007165 10.2 CCL11 CD4 ICOSLG IL10 IL13 IL3
5 positive regulation of interleukin-6 production GO:0032755 10.16 TSLP TNF IL6 IL17A
6 inflammatory response GO:0006954 10.16 TNF IL9 IL6 IL5 IL17A IL13
7 positive regulation of smooth muscle cell proliferation GO:0048661 10.15 TNF IL6 IL13
8 response to lipopolysaccharide GO:0032496 10.14 TNF IL13 IL10 FOXP3
9 negative regulation of inflammatory response GO:0050728 10.14 IL4 IL13 IL10 FOXP3
10 response to activity GO:0014823 10.13 TNF IL6 IL10
11 positive regulation of B cell proliferation GO:0030890 10.13 IL5 IL4 IL13
12 positive regulation of chemokine production GO:0032722 10.11 TSLP TNF IL6
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 10.11 IL6 IL5 IL3 CD4
14 negative regulation of endothelial cell apoptotic process GO:2000352 10.07 IL10 IL13 IL4
15 response to radiation GO:0009314 10.06 TNF FOXP3 CCL11
16 negative regulation of tumor necrosis factor production GO:0032720 10.06 FOXP3 IL10 IL4 POMC
17 liver regeneration GO:0097421 10.04 TNF IL6 IL10
18 defense response to Gram-negative bacterium GO:0050829 10.04 TSLP IL6 IL17A CD4
19 T cell activation GO:0042110 10.03 IL4 ICOSLG FOXP3 CD4
20 microglial cell activation GO:0001774 10.02 IL13 IL4 TNF
21 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.01 IL17A IL6 TNF
22 positive regulation of interleukin-10 production GO:0032733 10.01 TSLP IL6 IL4 IL13
23 negative regulation of neurogenesis GO:0050768 10 TNF IL6 CCL11
24 type 2 immune response GO:0042092 9.97 IL4 IL10
25 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.97 TNF IL6 IL5 IL10
26 vascular endothelial growth factor production GO:0010573 9.96 TNF IL6
27 negative regulation of cytokine production involved in immune response GO:0002719 9.95 IL10 TNF
28 positive regulation of mononuclear cell migration GO:0071677 9.94 IL4 TNF
29 positive regulation of receptor signaling pathway via STAT GO:1904894 9.94 IL6 TSLP
30 regulation of isotype switching GO:0045191 9.92 IL4 IL10
31 positive regulation of immunoglobulin production GO:0002639 9.92 IL10 IL13 IL5 IL6
32 negative regulation of chronic inflammatory response GO:0002677 9.91 IL4 FOXP3
33 negative regulation of complement-dependent cytotoxicity GO:1903660 9.88 IL4 IL13
34 chronic inflammatory response to antigenic stimulus GO:0002439 9.78 TNF IL10
35 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 TSLP TNF IL6 IL4 IL3 IL13
36 immune response GO:0006955 9.55 TNF IL9 IL6 IL5 IL4 IL3

Molecular functions related to Trichinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.73 IL9 IL6 IL5 IL4 IL3 IL10
2 cytokine activity GO:0005125 9.64 TSLP TNF IL9 IL6 IL5 IL4
3 cytokine receptor binding GO:0005126 9.33 IL9 IL4 IL13

Sources for Trichinosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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