MCID: TRC023
MIFTS: 44

Trichinosis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Trichinosis

MalaCards integrated aliases for Trichinosis:

Name: Trichinosis 12 77 54 60 3 15 17
Trichinellosis 54 60 3 45 74
Human Trichinellosis 54 74
Trichinella Spiralis Infection 12
Infection with Trichinella 54
Trichiniasis 54

Characteristics:

Orphanet epidemiological data:

60
trichinellosis
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:9784
ICD9CM 36 124
MeSH 45 D014235
NCIt 51 C85199
SNOMED-CT 69 88264003
ICD10 34 B75
MESH via Orphanet 46 D014235
ICD10 via Orphanet 35 B75
UMLS via Orphanet 75 C0040896
Orphanet 60 ORPHA863

Summaries for Trichinosis

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 863Disease definitionTrichinellosis is a zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus Trichinella and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur.Visit the Orphanet disease page for more resources.

MalaCards based summary : Trichinosis, also known as trichinellosis, is related to enterobiasis and myocarditis. An important gene associated with Trichinosis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Glucocorticoid receptor regulatory network and Innate Lymphoid Cell Differentiation Pathways. The drugs Iodine and cadexomer iodine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and eye, and related phenotype is Reduced mammosphere formation.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi. Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur.

CDC : 3 Image: Center: Trichinella larva in muscle tissue from an Alaskan bear. Image photographed at 200x magnification. L/R: Pigs, feral hogs, cougars and black bears can all harbor Trichinella infection. Successful trichinae control programs by the U.S. pork industry have nearly eliminated the disease in domestic swine raised in confinement, but hogs raised outdoors in close contact with rodents and other wildlife have an increased chance of acquiring Trichinella infection. Credit: L to R: USDAExternal, NASA/KSCExternal, DPDx, U.S. Fish & Wildlife ServiceExternal.

Wikipedia : 77 Trichinosis is a parasitic disease caused by roundworms of the Trichinella type. During the initial... more...

Related Diseases for Trichinosis

Diseases related to Trichinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 enterobiasis 29.9 IL4 IL9
2 myocarditis 10.2
3 arthritis 10.2
4 mastocytosis 10.2
5 hypereosinophilic syndrome 10.2
6 allergic encephalomyelitis 10.2
7 virus associated hemophagocytic syndrome 10.2 IL4 PIK3C2A
8 encephalitis 10.2
9 foot drop 10.1
10 myositis 10.1
11 thrombosis 10.1
12 squamous cell carcinoma 10.1
13 osteomyelitis 10.1
14 jak3-deficient severe combined immunodeficiency 10.1 IL4 IL9
15 vernal conjunctivitis 10.0 IL4 POMC
16 severe combined immunodeficiency, x-linked 10.0 IL4 IL9
17 extrinsic cardiomyopathy 10.0 IL4 PIK3C2A
18 oral squamous cell carcinoma 10.0
19 trypanosomiasis 10.0
20 echinococcosis 10.0
21 cholera 10.0
22 polymyositis 10.0
23 pigmentary disorder, reticulate, with systemic manifestations, x-linked 9.9
24 taeniasis 9.9
25 malignant fibroxanthoma 9.9
26 histiocytoma 9.9
27 fibrous histiocytoma 9.9
28 pyomyositis 9.9
29 parasitic helminthiasis infectious disease 9.9
30 irritable bowel syndrome 9.9
31 toxocariasis 9.9
32 hypoglycemia 9.9
33 undifferentiated pleomorphic sarcoma 9.9
34 multiple sclerosis 9.9
35 toxoplasmosis 9.9
36 cytokine deficiency 9.9
37 ascaris lumbricoides infection 9.9
38 myocardial infarction 9.9
39 acute myocardial infarction 9.9
40 sinusitis 9.9
41 exanthem 9.9
42 atrioventricular block 9.9
43 second-degree atrioventricular block 9.9
44 penicillin allergy 9.9
45 desmoid tumor 9.9
46 cysticercosis 9.9
47 endocarditis 9.9
48 meningoencephalitis 9.9
49 giardiasis 9.9
50 hemiplegia 9.9

Graphical network of the top 20 diseases related to Trichinosis:



Diseases related to Trichinosis

Symptoms & Phenotypes for Trichinosis

GenomeRNAi Phenotypes related to Trichinosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 IL9 NT5C3A NUMBL PIK3C2A POMC

Drugs & Therapeutics for Trichinosis

Drugs for Trichinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
2 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Trichinosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: trichinellosis

Genetic Tests for Trichinosis

Anatomical Context for Trichinosis

MalaCards organs/tissues related to Trichinosis:

42
Testes, Skin, Eye, Skeletal Muscle, Bone Marrow, Lymph Node, Cortex

Publications for Trichinosis

Articles related to Trichinosis:

(show top 50) (show all 1213)
# Title Authors Year
1
Epidemiology of taeniosis, cysticercosis and trichinellosis in Iran: A systematic review. ( 30575317 )
2019
2
A serological survey of echinococcosis, toxocariasis and trichinellosis among rural inhabitants of Central Yakutia. ( 31046654 )
2019
3
Human Trichinosis and febrile myositis. ( 30968127 )
2019
4
The epidemiology of trichinellosis in the Arctic territories of a Far Eastern District of the Russian Federation. ( 29382411 )
2019
5
Possible case of trichinellosis associated with beaver (Castor fiber) meat. ( 29720291 )
2019
6
Human trichinellosis caused by Trichinella britovi in Greece, and literature review. ( 30758280 )
2019
7
Epidemiology of human trichinellosis in Vojvodina province, Serbia, from 2005 to 2016. ( 30922089 )
2019
8
Diagnostic challenges in systemic pruritic erythema: History played a key role for diagnosis of trichinellosis. ( 31021003 )
2019
9
A Community-Based Study to Estimate the Seroprevalence of Trichinellosis and Echinococcosis in the Roma and Non-Roma Population of Slovakia. ( 29393919 )
2018
10
The impact of anthelminthic therapeutics on serological and tissues apoptotic changes induced by experimental trichinosis. ( 29844628 )
2018
11
Trichinellosis Outbreak Linked to Consumption of Privately Raised Raw Boar Meat - California, 2017. ( 29494570 )
2018
12
Trichinella britovi in Game Meat Linked to Human Trichinellosis Outbreak in Serbia. ( 29993314 )
2018
13
Killing the muscular larvaeā€‚of Trichinella spiralis and the anti-fibrotic effect of the combination of Wortmannilatone F and recombinant G31P in a murine model of trichinellosis. ( 30372905 )
2018
14
Trichinella Spiralis: Impact on the Expression of Toll-like Receptor 4 (TLR4) Gene During the Intestinal Phase of Experimental Trichinellosis. ( 30729207 )
2018
15
Trichinellosis surveillance in wildlife in northeastern argentine patagonia. ( 31014615 )
2018
16
A systematic review of taeniasis, cysticercosis and trichinellosis in Vietnam. ( 28320455 )
2017
17
Ultrastructural preservation of tissues and their reaction to the infection with trichinella in the El Plomo mummy: Muscle fiber ultrastructure and trichinosis/mummy of the Cerro El Plomo. ( 28475269 )
2017
18
Implication of artemisinin nematocidal activity on experimental trichinellosis: In vitro and in vivo studies. ( 27894908 )
2017
19
T-cell clones in human trichinellosis: Evidence for a mixed Th1/Th2 response. ( 28106258 )
2017
20
Meat sources of infection for outbreaks of human trichinellosis. ( 28213036 )
2017
21
New insights on serodiagnosis of trichinellosis during window period: early diagnostic antigens from Trichinella spiralis intestinal worms. ( 28219418 )
2017
22
Trichinellosis outbreak due to wild boar meat consumption in southern Italy. ( 28241860 )
2017
23
Modified dot-ELISA for diagnosis of human trichinellosis. ( 28438521 )
2017
24
Epidemiological studies on trichinellosis in pigs (Sus scofa) in India. ( 28615865 )
2017
25
Proteomic Analysis of Trichinella spiralis Adult Worm Excretory-Secretory Proteins Recognized by Sera of Patients with Early Trichinellosis. ( 28620363 )
2017
26
Two Outbreaks of Trichinellosis Linked to Consumption of Walrus Meat - Alaska, 2016-2017. ( 28683055 )
2017
27
Current Research of Trichinellosis in China. ( 28824597 )
2017
28
Serum IgE and IgG4 against muscle larva excretory-secretory products during the early and late phases of human trichinellosis. ( 28932905 )
2017
29
Detection of Experimental Swine Trichinellosis Using Commercial Elisa Test. ( 29166274 )
2017
30
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis. ( 29320813 )
2017
31
Regulatory parameters of the lung immune response during the early phase of experimental trichinellosis. ( 27211081 )
2016
32
A cluster of three cases of trichinellosis linked to bear meat consumption in the Arctic. ( 27296583 )
2016
33
Inadequate labeling of pork sausages prepared in Corsica causing a trichinellosis outbreak in France. ( 27317463 )
2016
34
Nitazoxanide anthelmintic activity against the enteral and parenteral phases of trichinellosis in experimentally infected rats. ( 27585500 )
2016
35
Outbreak of trichinellosis related to eating imported wild boar meat, Belgium, 2014. ( 27684098 )
2016
36
The 14th International Conference on Trichinellosis. ( 27765428 )
2016
37
Matrix metalloproteinase (MMP)-9: A realiable marker for inflammation in early human trichinellosis. ( 27117947 )
2016
38
Evaluation of recombinant CXCL8(3-73)K11R/G31P in muscle fibrosis and Trichinella larvae encapsulation in a murine model of trichinellosis. ( 27089392 )
2016
39
Carbonic anhydrase enzyme as a potential therapeutic target for experimental trichinellosis. ( 26979731 )
2016
40
A 47-year-old woman with fever and periorbital oedema. Trichinellosis. ( 26951358 )
2016
41
Quantitative Risk Assessment of Human Trichinellosis Caused by Consumption of Pork Meat Sausages in Argentina. ( 26227185 )
2016
42
Early serodiagnosis of trichinellosis by ELISA using excretory-secretory antigens of Trichinella spiralis adult worms. ( 26394626 )
2015
43
Evaluation of newly isolated probiotics in the protection against experimental intestinal trichinellosis. ( 26386829 )
2015
44
New diagnostic antigens for early trichinellosis: the excretory-secretory antigens of Trichinella spiralis intestinal infective larvae. ( 26342828 )
2015
45
The Use of Recombinant 31 kDa Antigens of Trichinella spiralis for Serodiagnosis of Experimental Trichinellosis. ( 26246820 )
2015
46
Uncertainties in diagnosis, treatment and prevention of trichinellosis. ( 26243167 )
2015
47
Wild boars meat as a potential source of human trichinellosis in Poland: current data. ( 26204193 )
2015
48
Working group for trichinellosis--a way of systematic prevention, control and eradication of trichinellosis in the Republic of Croatia. ( 26040102 )
2015
49
An outbreak of trichinellosis by consumption of raw soft-shelled turtle meat in Korea. ( 25925182 )
2015
50
Trichinellosis in Vietnam. ( 25846295 )
2015

Variations for Trichinosis

Expression for Trichinosis

Search GEO for disease gene expression data for Trichinosis.

Pathways for Trichinosis

Pathways related to Trichinosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.24 IL4 POMC
2 11.16 IL4 IL9
3 10.82 IL4 IL9
4 10.46 IL4 IL9
5 10.04 IL4 IL9

GO Terms for Trichinosis

Biological processes related to Trichinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell redox homeostasis GO:0045454 8.96 PDIA2 TMX3
2 cytokine-mediated signaling pathway GO:0019221 8.8 IL4 NUMBL POMC

Molecular functions related to Trichinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL4 IL9
2 protein disulfide isomerase activity GO:0003756 8.62 PDIA2 TMX3

Sources for Trichinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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