MCID: TRC023
MIFTS: 47

Trichinosis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Trichinosis

MalaCards integrated aliases for Trichinosis:

Name: Trichinosis 12 77 54 60 15 17 3
Trichinellosis 54 60 45 74 3
Human Trichinellosis 54 74
Trichinella Spiralis Infection 12
Infection with Trichinella 54
Trichiniasis 54

Characteristics:

Orphanet epidemiological data:

60
trichinellosis
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:9784
ICD9CM 36 124
MeSH 45 D014235
NCIt 51 C85199
SNOMED-CT 69 88264003
ICD10 34 B75
MESH via Orphanet 46 D014235
ICD10 via Orphanet 35 B75
UMLS via Orphanet 75 C0040896
Orphanet 60 ORPHA863

Summaries for Trichinosis

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 863Disease definitionTrichinellosis is a zoonotic parasitic disease caused by the consumption of raw or undercooked meat (pork and wild game) infected by nematodes of the genus Trichinella and that is characterized by an enteral (intestinal) phase, that can be asymptomatic or that can manifests with diarrhea, nausea, vomiting and abdominal pain, and a parenteral (muscular) phase, manifesting with fever, periorbital edema, muscle swelling and pain, weakness, and in some cases, skin rash and peripheral edema. Rarely, potentially fatal cardiac (i.e. myocarditis), pulmonary (i.e. pneumonitis, respiratory failure), and nervous system (i.e. meningoencephalitis) complications may occur.Visit the Orphanet disease page for more resources.

MalaCards based summary : Trichinosis, also known as trichinellosis, is related to cytokine deficiency and enterobiasis. An important gene associated with Trichinosis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are T cell receptor signaling pathway and JAK-STAT signaling pathway (KEGG). The drugs Iodine and cadexomer iodine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and eye, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi. Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur.

CDC : 3 Trichinellosis, also called trichinosis, is a disease that people can get by eating raw or undercooked meat from animals infected with the microscopic parasite Trichinella.

Wikipedia : 77 Trichinosis is a parasitic disease caused by roundworms of the Trichinella type. During the initial... more...

Related Diseases for Trichinosis

Diseases related to Trichinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 cytokine deficiency 30.1 IL5 IL9
2 enterobiasis 29.7 IL4 IL5 IL9
3 virus associated hemophagocytic syndrome 10.3 IL4 PIK3C2A
4 extrinsic cardiomyopathy 10.2 IL4 PIK3C2A
5 jak3-deficient severe combined immunodeficiency 10.2 IL4 IL9
6 myocarditis 10.2
7 vernal conjunctivitis 10.2 IL4 POMC
8 nickel allergic contact dermatitis 10.2 IL4 IL5
9 allergic contact dermatitis 10.2 IL4 IL5
10 contact dermatitis 10.2 IL4 IL5
11 cough variant asthma 10.2 IL4 IL5
12 scleritis 10.2 IL4 IL5
13 egg allergy 10.2 IL4 IL5
14 inflammatory bowel disease 4 10.2 IL4 IL5
15 sulfamethoxazole allergy 10.2 IL4 IL5
16 atopic keratoconjunctivitis 10.2 IL4 IL5
17 keratoconjunctivitis 10.2 IL4 IL5
18 conjunctivitis 10.2 IL4 IL5
19 arthritis 10.2
20 mastocytosis 10.2
21 hypereosinophilic syndrome 10.2
22 allergic encephalomyelitis 10.2
23 status asthmaticus 10.2 IL5 PIK3C2A
24 angiostrongyliasis 10.2 IL4 IL5
25 intrinsic asthma 10.2 IL4 IL5
26 apple allergy 10.2 IL4 IL5
27 gaucher disease, type ii 10.2 IL4 IL5
28 non-suppurative otitis media 10.2 IL4 IL5
29 severe combined immunodeficiency, x-linked 10.2 IL4 IL9
30 latex allergy 10.2 IL4 IL5
31 eosinophilic meningitis 10.2 IL4 IL5
32 intestinal schistosomiasis 10.2 IL4 IL5
33 chronic tic disorder 10.2 IL4 IL5
34 filarial elephantiasis 10.2 IL4 IL5
35 chronic conjunctivitis 10.2 IL4 IL5
36 eosinophilic gastritis 10.2 IL4 IL5
37 kimura disease 10.2 IL4 IL5
38 vernal keratoconjunctivitis 10.2 IL4 IL5
39 toxic oil syndrome 10.2 IL4 IL5
40 urinary schistosomiasis 10.2 IL4 IL5
41 folliculitis 10.2 IL4 IL5
42 conjunctival disease 10.2 IL4 IL5
43 encephalitis 10.1
44 allergic bronchopulmonary aspergillosis 10.1 IL4 IL5
45 milk allergy 10.1 IL4 IL5
46 pulmonary eosinophilia 10.1 IL4 IL5
47 paranasal sinus disease 10.1 IL4 IL5
48 onchocerciasis 10.1 IL4 IL5
49 foot drop 10.1
50 allergic conjunctivitis 10.1 IL4 IL5

Graphical network of the top 20 diseases related to Trichinosis:



Diseases related to Trichinosis

Symptoms & Phenotypes for Trichinosis

GenomeRNAi Phenotypes related to Trichinosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 IL5 IL9 NUMBL PIK3C2A POMC

MGI Mouse Phenotypes related to Trichinosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.17 ARSI IL4 IL5 IL9 NUMBL PIK3C2A

Drugs & Therapeutics for Trichinosis

Drugs for Trichinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
2 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Trichinosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: trichinellosis

Genetic Tests for Trichinosis

Anatomical Context for Trichinosis

MalaCards organs/tissues related to Trichinosis:

42
Testes, Skin, Eye, Skeletal Muscle, Bone, Lymph Node, Bone Marrow

Publications for Trichinosis

Articles related to Trichinosis:

(show top 50) (show all 1182)
# Title Authors Year
1
Epidemiology of taeniosis, cysticercosis and trichinellosis in Iran: A systematic review. ( 30575317 )
2019
2
The epidemiology of trichinellosis in the Arctic territories of a Far Eastern District of the Russian Federation. ( 29382411 )
2019
3
Human trichinellosis caused by Trichinella britovi in Greece, and literature review. ( 30758280 )
2019
4
The impact of anthelminthic therapeutics on serological and tissues apoptotic changes induced by experimental trichinosis. ( 29844628 )
2018
5
Trichinellosis Outbreak Linked to Consumption of Privately Raised Raw Boar Meat - California, 2017. ( 29494570 )
2018
6
Possible case of trichinellosis associated with beaver (Castor fiber) meat. ( 29720291 )
2018
7
Trichinella britovi in Game Meat Linked to Human Trichinellosis Outbreak in Serbia. ( 29993314 )
2018
8
Killing the muscular larvae of Trichinella spiralis and the anti-fibrotic effect of the combination of Wortmannilatone F and recombinant G31P in a murine model of trichinellosis. ( 30372905 )
2018
9
Trichinella Spiralis: Impact on the Expression of Toll-like Receptor 4 (TLR4) Gene During the Intestinal Phase of Experimental Trichinellosis. ( 30729207 )
2018
10
Ultrastructural preservation of tissues and their reaction to the infection with trichinella in the El Plomo mummy: Muscle fiber ultrastructure and trichinosis/mummy of the Cerro El Plomo. ( 28475269 )
2017
11
Serum IgE and IgG4 against muscle larva excretory-secretory products during the early and late phases of human trichinellosis. ( 28932905 )
2017
12
Implication of artemisinin nematocidal activity on experimental trichinellosis: In vitro and in vivo studies. ( 27894908 )
2017
13
T-cell clones in human trichinellosis: Evidence for a mixed Th1/Th2 response. ( 28106258 )
2017
14
Meat sources of infection for outbreaks of human trichinellosis. ( 28213036 )
2017
15
New insights on serodiagnosis of trichinellosis during window period: early diagnostic antigens from Trichinella spiralis intestinal worms. ( 28219418 )
2017
16
Trichinellosis outbreak due to wild boar meat consumption in southern Italy. ( 28241860 )
2017
17
Modified dot-ELISA for diagnosis of human trichinellosis. ( 28438521 )
2017
18
Epidemiological studies on trichinellosis in pigs (Sus scofa) in India. ( 28615865 )
2017
19
Proteomic Analysis of Trichinella spiralis Adult Worm Excretory-Secretory Proteins Recognized by Sera of Patients with Early Trichinellosis. ( 28620363 )
2017
20
Two Outbreaks of Trichinellosis Linked to Consumption of Walrus Meat - Alaska, 2016-2017. ( 28683055 )
2017
21
Current Research of Trichinellosis in China. ( 28824597 )
2017
22
Detection of Experimental Swine Trichinellosis Using Commercial Elisa Test. ( 29166274 )
2017
23
Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis. ( 29320813 )
2017
24
Quantitative Risk Assessment of Human Trichinellosis Caused by Consumption of Pork Meat Sausages in Argentina. ( 26227185 )
2016
25
Matrix metalloproteinase (MMP)-9: A realiable marker for inflammation in early human trichinellosis. ( 27117947 )
2016
26
Outbreak of trichinellosis related to eating imported wild boar meat, Belgium, 2014. ( 27684098 )
2016
27
The 14th International Conference on Trichinellosis. ( 27765428 )
2016
28
Wild boars meat as a potential source of human trichinellosis in Poland: current data. ( 26204193 )
2015
29
Trichinellosis outbreak caused by meat from a wild boar hunted in an Italian region considered to be at negligible risk for Trichinella. ( 25103623 )
2015
30
Characterization of a Trichinella spiralis 31 kDa protein and its potential application for the serodiagnosis of trichinellosis. ( 25447831 )
2015
31
Atherosclerosis, trichinellosis and Egyptian mummies. ( 25454209 )
2015
32
Trichinellosis surveillance--United States, 2008-2012. ( 25590865 )
2015
33
The low global burden of trichinellosis: evidence and implications. ( 24953055 )
2015
34
Consumption of untested pork contributed to over two-thousand clinical cases of human trichinellosis in Romania. ( 25651698 )
2014
35
Acute renal failure associated with albendazole therapy in a patient with trichinosis. ( 24842347 )
2014
36
Ocular system involvement in the course of human trichinellosis. Pathological and diagnostic aspects. ( 25119365 )
2014
37
Clinical & biochemical profile of trichinellosis outbreak in north India. ( 25366210 )
2014
38
Characterization of albendazole-randomly methylated-β-cyclodextrin inclusion complex and in vivo evaluation of its antihelmitic activity in a murine model of Trichinellosis. ( 25406084 )
2014
39
Molecular identification of Trichinella spiralis nudix hydrolase and its induced protective immunity against trichinellosis in BALB/c mice. ( 25522912 )
2014
40
Atypical case of trichinellosis. ( 23608929 )
2014
41
Description of an outbreak of human trichinellosis in an area of Argentina historically regarded as Trichinella-free: the importance of surveillance studies. ( 24444651 )
2014
42
Cardiac parasitic infection in trichinellosis associated with right ventricle outflow tract obstruction. ( 24782966 )
2014
43
Trichinellosis caused by consumption of wild boar meat - Illinois, 2013. ( 24848218 )
2014
44
Anti-Trichinella IgG in ethnic minorities living in Trichinella-endemic areas in northwest Vietnam: study of the predictive value of selected clinical signs and symptoms for the diagnosis of trichinellosis. ( 25076109 )
2014
45
Trichinosis caused by ingestion of raw soft-shelled turtle meat in Korea. ( 23710091 )
2013
46
Does congenital trichinellosis exist? ( 23017824 )
2013
47
Prevalence and some risk factors associated with trichinellosis in backyard pig farms in Zaria, Nigeria. ( 23264057 )
2013
48
Seroprevalence of trichinellosis in domestic animals in northwestern Vietnam. ( 23265187 )
2013
49
Identifying risk factors for symptoms of severe trichinellosis--a case study of 143 infected persons in Brasov, Romania 2001-2008. ( 23433989 )
2013
50
Retrospective epidemiological survey of diagnostic errors and their implications in the development of human trichinellosis in Braşov County-Romania over a period of 10 years. ( 23455035 )
2013

Variations for Trichinosis

Expression for Trichinosis

Search GEO for disease gene expression data for Trichinosis.

Pathways for Trichinosis

GO Terms for Trichinosis

Biological processes related to Trichinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.26 IL4 IL5 IL9 POMC
2 positive regulation of B cell proliferation GO:0030890 9.16 IL4 IL5
3 cytokine-mediated signaling pathway GO:0019221 8.92 IL4 IL5 NUMBL POMC

Molecular functions related to Trichinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 IL4 IL5 IL9
2 cytokine receptor binding GO:0005126 9.16 IL4 IL9
3 growth factor activity GO:0008083 9.13 IL4 IL5 IL9
4 protein disulfide isomerase activity GO:0003756 8.62 PDIA2 TMX3

Sources for Trichinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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