MCID: TRC003
MIFTS: 53

Trichomoniasis

Categories: Infectious diseases, Nephrological diseases, Reproductive diseases

Aliases & Classifications for Trichomoniasis

MalaCards integrated aliases for Trichomoniasis:

Name: Trichomoniasis 12 73 54 42 3 15 32
Trichomonas Infections 44 70
Trichomonas Infection 12 3

Classifications:



External Ids:

Disease Ontology 12 DOID:1947
ICD9CM 34 131
MeSH 44 D014245
NCIt 50 C35720
SNOMED-CT 67 56335008
ICD10 32 A59 A59.9
UMLS 70 C0040921

Summaries for Trichomoniasis

MedlinePlus : 42 Trichomoniasis is a sexually transmitted disease caused by a parasite. It spreads from person to person during sex. Many people do not have any symptoms. If you do get symptoms, they usually happen within 5 to 28 days after being infected. It can cause vaginitis in women. Symptoms include Yellow-green or gray discharge from the vagina Discomfort during sex Vaginal odor Painful urination Itching burning, and soreness of the vagina and vulva Most men do not have symptoms. If they do, they may have Itching or irritation inside the penis Burning after urination or ejaculation Discharge from the penis Trichomoniasis can increase the risk of getting or spreading other sexually transmitted diseases. Pregnant women with trichomoniasis are more likely to give birth too early, and their babies are more likely have a low birth weight. Lab tests can tell if you have the infection. Treatment is with antibiotics. If you are infected, you and your partner must be treated. Correct usage of latex condoms greatly reduces, but does not eliminate, the risk of catching or spreading trichomoniasis. If your or your partner is allergic to latex, you can use polyurethane condoms. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex. Centers for Disease Control and Prevention

MalaCards based summary : Trichomoniasis, also known as trichomonas infections, is related to syphilis and oral candidiasis, and has symptoms including fever, pruritus and pelvic pain. An important gene associated with Trichomoniasis is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Acetylcysteine and Cysteine have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and prostate, and related phenotypes are immune system and neoplasm

Disease Ontology : 12 A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively.

CDC : 3 Trichomoniasis (or "trich") is a very common sexually transmitted disease (STD). It is caused by infection with a protozoan parasite called Trichomonas vaginalis. Although symptoms of the disease vary, most people who have the parasite cannot tell they are infected.

Wikipedia : 73 Trichomoniasis (trich) is an infectious disease caused by the parasite Trichomonas vaginalis. About 70%... more...

Related Diseases for Trichomoniasis

Diseases related to Trichomoniasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 666)
# Related Disease Score Top Affiliating Genes
1 syphilis 30.4 TNF IL6 CD4 CCR5
2 oral candidiasis 30.3 SLPI CXCL8 CD4
3 candidiasis 30.2 TNF IL6 IL2 IL1B IL10 CXCL8
4 chlamydia 30.2 TNF IL6 IL1B IL10 CXCL8
5 bacterial vaginosis 30.1 TNF LAP3 IL6 IL1B IL10 CXCL8
6 lung abscess 30.0 TNF IL6 CD4
7 vaginitis 30.0 TNF SLPI LAP3 IL6 IL1B IL10
8 placenta disease 30.0 TNF IL6 IL1B CXCL8
9 cystitis 29.9 TNF IL6 IL2 CXCL8
10 erythema multiforme 29.8 TNF IL6 IL2 CXCL8
11 salpingitis 29.8 TNF IL6 CD4
12 cellulitis 29.8 TNF IL6 CD4
13 urethritis 29.7 TNF IL6 IL1B IL10 EPPIN CXCL8
14 tracheitis 29.7 TNF IL6 IL1B CXCL8
15 vaginal discharge 29.7 TNF SLPI LAP3 IL6 IL1B IL10
16 endometritis 29.7 TNF IL6 IL1B CXCL8
17 amebiasis 29.6 TNF IL1B IL10 CXCL8 CD4
18 human immunodeficiency virus infectious disease 29.6 TNF IL2 IL10 CD4 CCR5
19 bronchiectasis 29.5 TNF SLPI IL6 IL1B CXCL8
20 schistosomiasis 29.5 TNF LGMN IL2 IL10
21 toxoplasmosis 29.5 TNF IL6 IL1B IL10 CCR5
22 filariasis 29.4 TNF IL6 IL2 IL10
23 prostatitis 29.4 TNF IL6 IL2 IL1B IL10 CXCL8
24 rhinitis 29.4 TNF IL6 IL10 CXCL8
25 sarcoidosis 1 29.4 TNF IL2 IL1B CD4 CCR5
26 erythema nodosum 29.3 TNF IL6 IL1B IL10 CXCL8
27 esophagitis 29.3 TNF IL6 IL1B IL10 CXCL8
28 pharyngitis 29.3 TNF IL6 IL1B CXCL8 CD4
29 actinomycosis 29.1 TNF IL6 IL1B IL10 CD4
30 trypanosomiasis 29.1 TNF IL6 IL1B IL10 CXCL8
31 human immunodeficiency virus type 1 29.1 TNF SLPI IL2 IL10 CD4 CCR5
32 acute pancreatitis 29.1 TNF IL6 IL1B IL10 CXCL8
33 immune deficiency disease 29.0 TNF SLPI IL6 IL2 IL1B IL10
34 cervicitis 28.9 TNF IL6 IL2 IL1B IL10 CXCL8
35 leishmaniasis 28.9 TNF LMLN IL6 IL2 IL1B IL10
36 allergic disease 28.9 TNF IL6 IL2 IL1B IL10 CXCL8
37 chorioamnionitis 28.9 TNF SLPI IL6 IL1B IL10 CXCL8
38 diarrhea 28.9 TNF IL6 IL2 IL1B IL10 CXCL8
39 bacterial infectious disease 28.9 TNF IL6 IL1B IL10 CXCL8 CD4
40 fungal infectious disease 28.7 TNF IL6 IL2 IL1B IL10 CXCL8
41 stomatitis 28.7 TNF IL6 IL2 IL1B IL10 CXCL8
42 peripheral nervous system disease 28.7 TNF IL6 IL2 IL1B IL10 CXCL8
43 cystic fibrosis 28.5 TNF SLPI IL6 IL2 IL1B IL10
44 parasitic protozoa infectious disease 28.4 TNF LMLN IL6 IL2 IL1B IL10
45 vaginal disease 27.6 TNF SLPI LAP3 IL6 IL2 IL1B
46 trichomonas tenax trichomoniasis 11.3
47 trichomonas vaginalis trichomoniasis 11.3
48 dientamoebiasis 11.2
49 deep keratitis 10.4 SLPI IL2
50 balanoposthitis 10.4 SLPI IL2

Comorbidity relations with Trichomoniasis via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Trichomoniasis:



Diseases related to Trichomoniasis

Symptoms & Phenotypes for Trichomoniasis

UMLS symptoms related to Trichomoniasis:


fever; pruritus; pelvic pain

MGI Mouse Phenotypes related to Trichomoniasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 CCR5 CD4 IL10 IL1B IL2 IL6
2 neoplasm MP:0002006 9.1 CCR5 IL10 IL1B IL2 IL6 TNF

Drugs & Therapeutics for Trichomoniasis

Drugs for Trichomoniasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
3 Antibiotics, Antitubercular Phase 4
4 Respiratory System Agents Phase 4
5 Protective Agents Phase 4
6 Expectorants Phase 4
7 Antidotes Phase 4
8 Antioxidants Phase 4
9 N-monoacetylcystine Phase 4
10 Antiviral Agents Phase 4
11
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
12
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
13
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
14
Tinidazole Approved, Investigational Phase 3 19387-91-8 5479
15
Secnidazole Approved Phase 3 3366-95-8
16
Metronidazole Approved Phase 3 443-48-1 4173
17
Dihydroartemisinin Approved, Experimental, Investigational Phase 3 71939-50-9 6918483
18
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
19
Piperaquine Approved, Experimental, Investigational Phase 3 4085-31-8 5079497
20
Pyrimethamine Approved, Investigational, Vet_approved Phase 3 58-14-0 4993
21
Sulfadoxine Approved, Investigational Phase 3 2447-57-6 17134
22
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
23 Cytochrome P-450 CYP3A Inhibitors Phase 3
24 Alkylating Agents Phase 3
25 Anti-Infective Agents, Local Phase 3
26 Hormone Antagonists Phase 3
27 Cytochrome P-450 Enzyme Inhibitors Phase 3
28 Hormones Phase 3
29 Antifungal Agents Phase 3
30 Antiparasitic Agents Phase 3
31 Anti-Infective Agents Phase 3
32 Anti-Bacterial Agents Phase 3
33 Antiprotozoal Agents Phase 3
34 Vitamin B9 Phase 3
35 Folic Acid Antagonists Phase 3
36 Folate Phase 3
37 Vitamin B Complex Phase 3
38 Antimalarials Phase 3
39 Fanasil, pyrimethamine drug combination Phase 3
40
Titanium dioxide Approved Phase 2 13463-67-7

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Studying the Role of N-Acetyl Cysteine Either Alone or in Combination With Metronidazole in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4 N-Acetyl cysteine;Metronidazole + N-Acetyl cysteine;metronidazole
2 Randomized Phase IV Trial of Metronidazole Single Dose Versus 7 Day Dose for Treatment of Trichomonas Vaginalis Among HIV-infected Women Completed NCT01018095 Phase 4 Metronidazole
3 A Randomised Controlled Trial of Single Dose Tinidazole+Fluconazole Versus Longer Courses of Metronidazole+Clotrimazole in the Management of West African Women With Vaginal Discharge Completed NCT00313131 Phase 3 tinidazole+fluconazole vs metronidazole+clotrimazole
4 A Phase 3, Multi-center, Prospective, Randomized, Placebo-Controlled, Delayed Treatment, Double-Blind Study to Evaluate the Effectiveness and Safety of a Single Oral Dose of Solosec® Granules Containing 2 Grams of Secnidazole for the Treatment of Trichomoniasis Completed NCT03935217 Phase 3 Secnidazole;Placebo
5 Trichomonas Vaginalis Repeat Infections Among HIV Negative Women Completed NCT01832480 Phase 3 MTZ 500 mg twice daily x 7 days;MTZ 2 g
6 Effects of Metronidazole Plus Intermittent Preventive Treatment of Malaria in Pregnancy on Birth Outcomes: a Randomised Controlled Trial in Zambia Recruiting NCT04189744 Phase 3 IPTp-sulphadoxine-pyrimethamine plus metronidazole;IPTp-dihydroartemisinin-piperaquine plus metronidazole;IPTp-sulphadoxine-pyrimethamine
7 Neo-Penotran Forte Vaginal Suppository for Vaginal Trichomoniasis Completed NCT01361048 Phase 2 oral metronidazole;neo penotran forte;neo penotran forte once a day
8 A Brief, Clinic-Based, Safer Sex Program for Young African-American Men Completed NCT01439503 Phase 2
9 Prospective Study for Cost-Effectiveness Strategies to Improve Partner Notification: Female Trichomonas and Male Urethritis Studies Completed NCT00207467 Phase 2
10 A Double-Blind, Randomized Trial of Monthly Treatment With Topical Metronidazole and Miconazole Co-formulated Vaginal Suppositories Versus Placebo for Preventing Vaginal Infections in HIV-seronegative Women Completed NCT01230814 Phase 2 Neo-Penotran® Forte (active ingredient Metronidazole & Miconazole Nitrate);Placebo
11 A Single Dose, Two-Period, Two-Treatment, Two-Way Crossover Bioequivalence Study of Tinidazole 500 mg Tablets Under Fed Conditions Completed NCT01591889 Phase 1 Tinidazole;Tinidazole
12 Trichomonas Vaginalis Genotyping in Upper Egypt Unknown status NCT03614286
13 Trichomoniasis: Genotype and Phenotype Correlations in African American Women Completed NCT00998530
14 Control of Trichomoniasis - A Paradigm for STD Control Completed NCT00334555
15 DNA Clearance of Uncomplicated Trichomonas Vaginalis Infections in HIV Negative Women Completed NCT01874158
16 Non-Invasive Sexually Transmitted Disease Testing in Women Seeking Emergency Contraception or Urine Pregnancy Testing: Meeting the Needs of an At-Risk Population Completed NCT00978848
17 Pivotal Study of a Single-Use, Point-of-Care Molecular Diagnostic Device for the Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) in Women Completed NCT03852316
18 A Validation Study of the Cepheid Xpert CT/NG for Detecting Chlamydia Trachomatis and Neisseria Gonorrhoeae in Rectal Samples Completed NCT02099760
19 Prospective Collection of Female First-catch Urine, Vaginal Swab, Endocervical Swab, and Cervical Specimens for Testing With the APTIMA Trichomonas Vaginalis Assay Completed NCT01427023
20 A Validation Study of Genzyme Diagnostics OSOM Trichomonas Rapid Test and BVBlue Test Completed NCT00682851
21 Comparing NAAT Testing to Standard Methods in Diagnosis of Vaginal Infections in the General Gynecology and Vulvovaginal Referral Offices. Completed NCT02203942
22 Validity of Patient-Collected Wet Mounts Completed NCT02641717
23 "Solana™ Trichomonas Assay Field Study" Completed NCT02566447
24 Clinical Evaluation of the Click Sexual Health Test for the Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) in Women Completed NCT04098900
25 Clinical Study of STI Screening to Prevent Adverse Birth and New-born Outcomes Not yet recruiting NCT04446611
26 Clinical Study of a Single-Use, Point-of-Care Molecular Diagnostic Device for the Detection of Neisseria Gonorrhoeae (NG), Trichomonas Vaginalis (TV), and Chlamydia Trachomatis (CT) Utilizing Vaginal Swabs Terminated NCT03596151
27 Prospective Collection of Female First-catch Urine, Vaginal Swab,Cervical, and Endocervical Swab Specimens for Testing With the APTIMA Assays Terminated NCT01728103

Search NIH Clinical Center for Trichomoniasis

Cochrane evidence based reviews: trichomonas infections

Genetic Tests for Trichomoniasis

Anatomical Context for Trichomoniasis

MalaCards organs/tissues related to Trichomoniasis:

40
Cervix, Skin, Prostate, Neutrophil, Kidney, Breast, Eye

Publications for Trichomoniasis

Articles related to Trichomoniasis:

(show top 50) (show all 3185)
# Title Authors PMID Year
1
Sexually Transmitted Infections in Pregnancy: A Narrative Review of the Global Research Gaps, Challenges, and Opportunities. 42
32773611 2020
2
Co-infection with trichomonas vaginalis increases the risk of cervical intraepithelial neoplasia grade 2-3 among HPV16 positive female: a large population-based study. 42
32873233 2020
3
T. vaginalis in riverside women in Amazonia, Brazil: an experience using the EVALYN® BRUSH vaginal self-collection device. 42
32087075 2019
4
Comparison between secretory leukocytic protease inhibitor and reactive nitrogen intermediates levels in cervicovaginal secretions from symptomatic and asymptomatic trichomoniasis Egyptians patients. 54 61
17153694 2006
5
Cysteine proteases of Trichomonas vaginalis degrade secretory leukocyte protease inhibitor. 54 61
9728551 1998
6
Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides. 61
33356653 2021
7
Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles. 61
33556576 2021
8
Thermosensitive hydrogels for vaginal delivery of secnidazole as an approach to overcome the systemic side-effects of oral preparations. 61
33482314 2021
9
Trichomonas vaginalis serostatus and prostate cancer risk in Egypt: a case-control study. 61
33159459 2021
10
The Estimated Lifetime Medical Cost of Chlamydia, Gonorrhea, and Trichomoniasis in the United States, 2018. 61
33492090 2021
11
The Estimated Number and Lifetime Medical Cost of HIV Infections Attributable to Sexually Transmitted Infections Acquired in the United States in 2018: A Compilation of Published Modeling Results. 61
33492098 2021
12
Sexually Transmitted Infections Among US Women and Men: Prevalence and Incidence Estimates, 2018. 61
33492089 2021
13
The Estimated Direct Lifetime Medical Costs of Sexually Transmitted Infections Acquired in the United States in 2018. 61
33492093 2021
14
Genital Mycoplasma, Shigellosis, Zika, Pubic Lice, and Other Sexually Transmitted Infections: Neither Gone Nor Forgotten. 61
33492101 2021
15
The International Society for the Study of Vulvovaginal Disease Vaginal Wet Mount Microscopy Guidelines: How to Perform, Applications, and Interpretation. 61
33631782 2021
16
Estimating the Direct Medical Outpatient Costs of Diagnosis and Treatment of Trichomoniasis Among Commercially Insured Patients in the United States, 2016 to 2018. 61
32810026 2021
17
The molecular characterization and immune protection of adhesion protein 65 (AP65) of Trichomonas vaginalis. 61
33484808 2021
18
Atomic Structure of the Trichomonas vaginalis Double-Stranded RNA Virus 2. 61
33785622 2021
19
Topical microbicides for preventing sexually transmitted infections. 61
33719075 2021
20
Vulvovaginal candidiasis in Iran: A systematic review and meta-analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis. 61
33741400 2021
21
Physicochemical and Microbiological Stability of Compounded Metronidazole Suspensions in PCCA SuspendIt. 61
33798117 2021
22
Efficacy and Safety of Single Oral Dosing of Secnidazole for Trichomoniasis in Women: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled, Delayed-Treatment Study. 61
33768237 2021
23
Optimization of Coumarins Extraction from Pterocaulon balansae by Box-Behnken Design and Anti-Trichomonas vaginalis Activity. 61
33578433 2021
24
A review study on the anti-trichomonas activities of medicinal plants. 61
33610966 2021
25
TriTOX: A novel Trichomonas vaginalis assay platform for high-throughput screening of compound libraries. 61
33601283 2021
26
Effects of HIV voluntary medical male circumcision programs on sexually transmitted infections. 61
33315750 2021
27
Toward incorporating epigenetics into regulation of gene expression in the parasite Trichomonas vaginalis. 61
33599017 2021
28
Nitroaromatic Antibiotics as Nitrogen Oxide Sources. 61
33673069 2021
29
Nonviral sexually transmitted infections in pregnancy: current controversies and new challenges. 61
33337618 2021
30
Genital abnormalities, hormonal contraception, and HIV transmission risk in Rwandan serodifferent couples. 61
33560366 2021
31
Horizons and Group Motivational Enhancement Therapy: HIV Prevention for Alcohol-Using Young Black Women, a Randomized Experiment. 61
33678517 2021
32
High Prevalence of Sexually Transmitted Infections in Pregnant Women Living in Southern Brazil. 61
32976355 2021
33
Clinical validation of a new molecular test (Seegene Allplex™ Vaginitis) for the diagnosis of vaginitis: a cross-sectional study. 61
33540484 2021
34
Global survey of miRNAs and tRNA-derived small RNAs from the human parasitic protist Trichomonas vaginalis. 61
33514387 2021
35
Small RNAs Are Implicated in Regulation of Gene and Transposable Element Expression in the Protist Trichomonas vaginalis. 61
33408230 2021
36
Antitrichomonal activity and docking analysis of thiazole derivatives as TvMP50 protease inhibitors. 61
33073325 2021
37
Successful treatment of trichomoniasis with tinidazole following desensitization in a patient allergic to metronidazole. 61
33121364 2021
38
[Diagnosis and treatment guidelines for trichomoniasis (2021 revised edition)]. 61
33486921 2021
39
The Role of Purinergic Signaling in Trichomonas vaginalis Infection. 61
32888270 2021
40
Recent advances in the molecular biology of the protist parasite Trichomonas vaginalis. 61
33718943 2021
41
Anti-Parasitic Activity of Cherry Tomato Peel Powders. 61
33498638 2021
42
Comparative pharmacokinetics of metronidazole in healthy and Trichomonas gallinae infected pigeons (Columba livia domestica). 61
33491469 2021
43
Improving our understanding of the disproportionate incidence of STIs in heterosexual-identifying people of black Caribbean heritage: findings from a longitudinal study of sexual health clinic attendees in England. 61
33514680 2021
44
STI prevalence among men living with HIV engaged in safer conception care in rural, southwestern Uganda. 61
33657120 2021
45
Sexually transmitted infections among women living with HIV in a Brazilian city. 61
33417851 2021
46
Recent Advances in Nanosystems and Strategies for Vaginal Delivery of Antimicrobials. 61
33530510 2021
47
G-computation for policy-relevant effects of interventions on time-to-event outcomes. 61
33141177 2021
48
Assessment of syndromic management of curable sexually transmitted and reproductive tract infections among pregnant women: an observational cross-sectional study. 61
33516183 2021
49
Current and Future Trends in the Laboratory Diagnosis of Sexually Transmitted Infections. 61
33503917 2021
50
Prevalence, Etiology, and Associated Symptoms of Vaginal Discharge During Pregnancy in Women Seen in a Tertiary Care Hospital in Bihar. 61
33614308 2021

Variations for Trichomoniasis

Expression for Trichomoniasis

Search GEO for disease gene expression data for Trichomoniasis.

Pathways for Trichomoniasis

Pathways related to Trichomoniasis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 TNF SLPI LGMN IL6 IL2 IL1B
2
Show member pathways
13.85 TNF IL6 IL2 IL1B IL10 CXCL8
3
Show member pathways
13.7 TNF IL6 IL2 IL1B IL10 CXCL8
4
Show member pathways
13.56 TNF IL6 IL2 IL1B IL10 CXCL8
5
Show member pathways
13.4 TNF IL6 IL2 IL1B IL10 CXCL8
6
Show member pathways
13.38 TNF IL6 IL2 IL1B IL10 CXCL8
7
Show member pathways
13.24 TNF IL6 IL2 IL1B IL10 CXCL8
8
Show member pathways
13.22 TNF IL6 IL2 IL1B IL10 CXCL8
9
Show member pathways
12.99 TNF IL6 IL1B CXCL8 CD4 CCR5
10
Show member pathways
12.89 CXCL8 CD4 CCR5 CCL4L1 CCL20
11
Show member pathways
12.87 TNF IL6 IL2 IL1B ENTPD8 CXCL8
12
Show member pathways
12.82 TNF LGMN IL6 IL2 IL1B IL10
13
Show member pathways
12.66 TNF IL6 IL2 IL1B IL10 CD4
14
Show member pathways
12.63 TNF IL6 IL2 IL1B IL10 CD4
15
Show member pathways
12.61 TNF IL6 IL2 IL1B IL10 CD4
16
Show member pathways
12.4 TNF IL6 IL1B CXCL8 CCL20
17 12.36 TNF IL6 IL2 CD4
18
Show member pathways
12.36 TNF IL6 IL2 IL1B
19
Show member pathways
12.33 TNF IL6 IL1B CXCL8
20
Show member pathways
12.32 TNF IL6 IL2 IL1B IL10 CXCL8
21
Show member pathways
12.3 TNF IL1B IL10 CCR5
22
Show member pathways
12.29 TNF IL6 IL2 IL1B IL10
23 12.27 TNF IL6 IL1B CXCL8
24 12.27 TNF IL6 IL1B IL10
25
Show member pathways
12.26 TNF IL6 IL1B CXCL8 CCL20
26 12.24 TNF IL6 IL1B IL10 CXCL8
27
Show member pathways
12.09 TNF IL6 IL2 IL10 CXCL8 CCR5
28 12.07 TNF IL6 IL2 IL10 CD4
29 12.05 TNF IL6 IL1B IL10 CXCL8
30 12.04 TNF IL6 IL1B CCL20
31
Show member pathways
12.04 IL2 IL1B CD4 CCR5 CCL4L1
32 12.01 TNF IL1B CXCL8 CCL4L1
33 11.98 TNF IL6 IL1B CXCL8
34 11.98 TNF IL6 IL1B CD4
35 11.98 TNF IL6 IL1B IL10 CXCL8
36 11.96 TNF LTB4R IL6 IL2 IL1B CXCL8
37 11.94 TNF IL6 IL2 IL1B IL10 CXCL8
38 11.93 TNF IL6 IL1B CXCL8 CCL20
39
Show member pathways
11.87 IL6 IL1B CD4
40 11.85 TNF IL2 IL1B IL10 CD4
41 11.82 IL6 IL2 CXCL8
42 11.82 TNF IL6 IL1B IL10 CXCL8
43
Show member pathways
11.78 TNF IL2 CXCL8
44 11.76 TNF IL6 IL1B CXCL8
45
Show member pathways
11.73 TNF IL6 IL2 IL1B IL10 CD4
46 11.72 TNF IL6 IL10
47 11.69 TNF IL6 IL1B CXCL8
48
Show member pathways
11.69 TNF IL6 IL2 IL1B CXCL8
49 11.67 TNF IL6 IL2 IL1B IL10 CD4
50 11.6 TNF IL6 IL2

GO Terms for Trichomoniasis

Cellular components related to Trichomoniasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 TNF SLPI LGMN IL6 IL2 IL1B
2 extracellular space GO:0005615 9.32 TNF SLPI IL6 IL2 IL1B IL10

Biological processes related to Trichomoniasis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.27 LTB4R IL6 IL1B IL10 CXCL8 CD4
2 MAPK cascade GO:0000165 9.98 TNF IL2 IL1B CCR5
3 cell-cell signaling GO:0007267 9.95 IL2 IL1B CCR5 CCL20
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 TNF CD4 CCL4L1 CCL20
5 positive regulation of protein phosphorylation GO:0001934 9.91 TNF IL2 IL1B CD4
6 defense response to bacterium GO:0042742 9.91 TNF SLPI IL10 EPPIN CCL20
7 positive regulation of inflammatory response GO:0050729 9.86 TNF IL2 IL1B
8 positive regulation of interleukin-6 production GO:0032755 9.85 TNF IL6 IL1B
9 cellular response to interleukin-1 GO:0071347 9.85 CXCL8 CCL4L1 CCL20
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.84 TNF IL6 IL1B IL10
11 neutrophil chemotaxis GO:0030593 9.83 CXCL8 CCL4L1 CCL20
12 regulation of insulin secretion GO:0050796 9.83 TNF IL6 IL1B
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 TNF IL6 IL2
14 response to glucocorticoid GO:0051384 9.8 TNF IL6 IL10
15 positive regulation of interferon-gamma production GO:0032729 9.79 TNF IL2 IL1B
16 positive regulation of interleukin-8 production GO:0032757 9.78 TNF IL6 IL1B
17 monocyte chemotaxis GO:0002548 9.76 IL6 CCL4L1 CCL20
18 inflammatory response GO:0006954 9.76 TNF LTB4R IL6 IL1B CXCL8 CCR5
19 chemokine-mediated signaling pathway GO:0070098 9.73 CXCL8 CCR5 CCL4L1 CCL20
20 cellular response to lipopolysaccharide GO:0071222 9.73 TNF IL6 IL1B IL10 CXCL8 CCR5
21 positive regulation of JAK-STAT cascade GO:0046427 9.72 TNF IL6 IL10
22 positive regulation of T cell proliferation GO:0042102 9.71 IL6 IL2 IL1B CD4
23 negative regulation of neurogenesis GO:0050768 9.7 TNF IL6 IL1B
24 response to molecule of bacterial origin GO:0002237 9.67 IL10 CXCL8
25 positive regulation of immunoglobulin production GO:0002639 9.67 IL6 IL2 IL10
26 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
27 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
28 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
29 endothelial cell apoptotic process GO:0072577 9.64 TNF IL10
30 fusion of virus membrane with host plasma membrane GO:0019064 9.63 CD4 CCR5
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 TNF IL1B IL10
32 cytokine-mediated signaling pathway GO:0019221 9.61 TNF IL6 IL2 IL1B IL10 CXCL8
33 negative regulation of cytokine production involved in immune response GO:0002719 9.6 TNF IL10
34 positive regulation of fever generation GO:0031622 9.59 TNF IL1B
35 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
36 positive regulation of plasma cell differentiation GO:1900100 9.57 IL2 IL10
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 TNF IL1B
38 positive regulation of neuroinflammatory response GO:0150078 9.54 TNF IL6 IL1B
39 vascular endothelial growth factor production GO:0010573 9.5 TNF IL6 IL1B
40 immune response GO:0006955 9.36 TNF SLPI LTB4R IL6 IL2 IL1B

Molecular functions related to Trichomoniasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 TNF IL6 IL2 IL1B IL10 CXCL8
2 chemokine activity GO:0008009 9.13 CXCL8 CCL4L1 CCL20

Sources for Trichomoniasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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