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TTM
MCID: TRC010
MIFTS: 50

Trichotillomania (TTM)

Categories: Eye diseases, Gastrointestinal diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Trichotillomania

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MalaCards integrated aliases for Trichotillomania:

Name: Trichotillomania 57 12 73 20 72 36 29 13 6 44 15 39 70 32
Ttm 57 72
Hair-Pulling Syndrome 20

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant
multifactorial

Miscellaneous:
affected individuals can pull hair from any part of the body, including eyelashes and eyebrows
overlap with obsessive-compulsive disorder (ocd, )
overlap with tourette syndrome
affects 1 to 3% of the population
one patient reported with slitrk1 mutation (as of january 2010)


HPO:

31
trichotillomania:
Inheritance autosomal dominant inheritance multifactorial inheritance


Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Mental diseases Eye diseases Gastrointestinal diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0050587
OMIM® 57 613229
KEGG 36 H00864
MeSH 44 D014256
ICD10 32 F63.3
UMLS 70 C0040953
Sources

Summaries for Trichotillomania

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GARD : 20 Trichotillomania is a disorder characterized by an overwhelming urge to repeatedly pull out one's own hair, resulting in hair loss ( alopecia ). It is classified under the obsessive-compulsive and related disorders category. Trichotillomania results in highly variable patterns of hair loss. The scalp is the most common area of hair pulling, followed by the eyebrows, eyelashes, pubic and perirectal areas, axillae, limbs, torso, and face. The resulting alopecia can range from thin unnoticeable areas of hair loss to total baldness. Some people chew or swallow the hair they pull out (trichophagy), which can result in gastrointestinal problems or develop a trichobezoar (hairball in the intestines or stomach). In many cases, people with this disorder feel extreme tension when they feel an impulse, followed by relief, gratification or pleasure afterwards. The disorder may be mild and manageable, or severe and debilitating. The cause is unknown, though both environmental and genetic causes have been suspected. Treatment may involve cognitive behavior therapy, such as habit reversal training (learning to substitute the hair-pulling behavior) and/or drug therapy, but these are not always effective.

MalaCards based summary : Trichotillomania, also known as ttm, is related to loose anagen hair syndrome and kleptomania. An important gene associated with Trichotillomania is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Transmission across Chemical Synapses and Neuroscience. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and ovary, and related phenotypes are alopecia and obsessive-compulsive behavior

Disease Ontology : 12 An impulse control disorder that involves the uncontrollable plucking of ones hair.

OMIM® : 57 Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Tourette syndrome (GTS; 137580) or obsessive-compulsive disorder (OCD; 164230) (review by Novak et al., 2009). (613229) (Updated 05-Apr-2021)

KEGG : 36 Trichotillomania (TTM) is a chronic behavioral disorder characterized by the irresistible urge to pull out one's hair, resulting in noticeable hair loss. Mutations in SLITRK1 are found in patients with TTM.

UniProtKB/Swiss-Prot : 72 Trichotillomania: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder.

Wikipedia : 73 Trichotillomania (TTM), also known as hair pulling disorder or compulsive hair pulling, is a mental... more...

Sources

Related Diseases for Trichotillomania

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Diseases related to Trichotillomania via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 loose anagen hair syndrome 30.4 SLITRK1 DLGAP3
2 kleptomania 30.2 MAOA DLGAP3
3 impulse control disorder 30.0 SLITRK5 SLITRK1 MAOA HOXB8 DRD4 DLGAP3
4 personality disorder 30.0 PRL MAOA DRD4
5 body dysmorphic disorder 29.8 SLITRK5 SLC1A1 MAOA HOXB8 DLGAP3
6 obsessive-compulsive disorder 29.8 SLITRK5 SLITRK1 SLC1A1 PRL MAOA DRD4
7 dysthymic disorder 29.6 MAOA DRD4
8 anorexia nervosa 29.6 PRL MAOA DRD4
9 attention deficit-hyperactivity disorder 29.5 PRL MAOA DRD4 DLGAP1 DLG4
10 substance abuse 29.5 PRL MAOA DRD4
11 anxiety 29.4 SLC1A1 PRL MAOA GRM2 DRD4
12 mental depression 29.3 MIR24-1 MAOA GRM2 DRD4
13 major depressive disorder 29.3 PRL MAOA GRM2 DRD4
14 tic disorder 29.3 SLITRK5 SLITRK1 SLC1A1 MIR24-1 MAOA DRD4
15 pathological gambling 29.2 MAOA DRD4
16 bipolar disorder 29.2 SLC1A1 PRL MAOA KDM4C DRD4 DLG4
17 gilles de la tourette syndrome 29.2 SLITRK1 MIR24-1 MAOA DRD4 DLGAP3
18 restless legs syndrome 29.1 PRL MAOA DRD4
19 panic disorder 29.1 PRL MAOA DRD4
20 tobacco addiction 29.1 MAOA GRM2 DRD4
21 autism 28.9 SLITRK5 SLC1A1 PRL MAOA DRD4 DLG4
22 autism spectrum disorder 28.6 SLITRK5 SLITRK2 SLC1A1 MAOA DRD4 DLG4
23 alopecia 10.6
24 cardiac arrest 10.5
25 alopecia areata 10.5
26 major affective disorder 8 10.2
27 major affective disorder 9 10.2
28 dicarboxylic aminoaciduria 10.1 SLITRK5 SLC1A1 DLGAP3
29 pedophilia 10.1 PRL MAOA
30 sexual sadism 10.1 PRL MAOA
31 post-traumatic stress disorder 10.1
32 tinea capitis 10.1
33 neurotic disorder 10.1
34 eating disorder 10.1
35 dermatophytosis 10.1
36 leukemia, chronic lymphocytic 10.1
37 dementia 10.1
38 generalized anxiety disorder 10.1
39 stereotypic movement disorder 10.1
40 dermatitis 10.1
41 melancholia 10.0 PRL MAOA
42 ischemia 10.0
43 48,xyyy 10.0
44 back pain 10.0
45 pik3ca-related overgrowth syndrome 10.0
46 integumentary system disease 10.0 SIGLEC5 MIR24-1 KDM4C
47 borderline personality disorder 10.0
48 mood disorder 10.0
49 acute stress disorder 10.0
50 depression 10.0

Graphical network of the top 20 diseases related to Trichotillomania:



Diseases related to Trichotillomania
Sources

Symptoms & Phenotypes for Trichotillomania

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Human phenotypes related to Trichotillomania:

31
# Description HPO Frequency HPO Source Accession
1 alopecia 31 HP:0001596
2 obsessive-compulsive behavior 31 HP:0000722
3 hair-pulling 31 HP:0012167

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Skin Nails Hair Hair:
alopecia resulting from compulsive hair pulling

Neurologic Behavioral Psychiatric Manifestations:
hair pulling, chronic, compulsive, repetitive
distress and functional impairment resulting from hair pulling behavior

Clinical features from OMIM®:

613229 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Trichotillomania:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 BTBD3 DLG4 DLGAP1 DLGAP3 DRD4 GRM2
2 nervous system MP:0003631 9.36 DLG4 DLGAP3 DRD4 GRM2 HOXB8 MAOA
Sources

Drugs & Therapeutics for Trichotillomania

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Drugs for Trichotillomania (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585 135398745
4
Sertraline Approved Phase 4 79617-96-2 68617
5 Dopamine Agents Phase 4
6 Central Nervous System Stimulants Phase 4
7 Dopamine Uptake Inhibitors Phase 4
8 Neurotransmitter Agents Phase 4
9 Psychotropic Drugs Phase 4
10 Antidepressive Agents Phase 4
11 Antipsychotic Agents Phase 4
12 Gastrointestinal Agents Phase 4
13 Antiemetics Phase 4
14 Serotonin Uptake Inhibitors Phase 4
15
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
16
Dronabinol Approved, Illicit Phase 2, Phase 3 1972-08-3 16078
17 Analgesics, Non-Narcotic Phase 2, Phase 3
18 Hallucinogens Phase 2, Phase 3
19 Hormone Antagonists Phase 2, Phase 3
20 Analgesics Phase 2, Phase 3
21 Hormones Phase 2, Phase 3
22
Milk thistle Approved, Experimental, Investigational Phase 2 65666-07-1
23
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
24
Inositol Approved, Investigational, Withdrawn Phase 2 87-89-8
25
Ethanol Approved Phase 2 64-17-5 702
26
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
27
Memantine Approved, Investigational Phase 2 19982-08-2 4054
28
Cysteine Approved, Nutraceutical Phase 2 52-90-4 5862
29
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
30
Glutamic acid Approved, Nutraceutical Phase 2 56-86-0 33032
31 Protective Agents Phase 2
32 Antioxidants Phase 2
33 silymarin Phase 2
34 Respiratory System Agents Phase 2
35 Expectorants Phase 2
36 N-monoacetylcystine Phase 2
37 Antidotes Phase 2
38 Antiviral Agents Phase 2
39 Anti-Infective Agents Phase 2
40 Vitamin B9 Phase 2
41 Nutrients Phase 2
42 Micronutrients Phase 2
43 Trace Elements Phase 2
44 Vitamin B Complex Phase 2
45 Vitamins Phase 2
46 Folate Phase 2
47 Narcotics Phase 2
48 Narcotic Antagonists Phase 2
49 Excitatory Amino Acid Antagonists Phase 2
50 Antiparkinson Agents Phase 2

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Methylphenidate Treatment of Children and Adolescents Diagnosed With ADHD and Its Influence on Comorbid Trichotillomania Unknown status NCT00552266 Phase 4 Methylphenidate
2 A 12-Week, Double-Blind Trial of Olanzapine and Placebo in the Treatment of Trichotillomania Completed NCT00182507 Phase 4 Olanzapine
3 Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania Completed NCT00118014 Phase 4 Sertraline
4 A Double-Blind, Placebo-Controlled Study of Dronabinol in Trichotillomania and Other Body Focused Repetitive Behaviors Recruiting NCT03530800 Phase 2, Phase 3 Dronabinol;Placebo
5 Acceptance Enhanced Behavior Therapy for Trichotillomania Unknown status NCT00872742 Phase 2
6 Stepped Care in the Treatment of Trichotillomania Completed NCT01118637 Phase 2
7 Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania Completed NCT01654523 Phase 2
8 Silymarin Treatment of Trichotillomania in Children and Adults: A Double-Blind, Placebo-Controlled, Cross-Over Study Completed NCT02473913 Phase 2 Milk Thistle;Placebo
9 A Double-Blind, Placebo-Controlled Study of N-Acetyl Cysteine in Trichotillomania Completed NCT00354770 Phase 2 Placebo;N-Acetyl Cysteine
10 A Double-Blind, Placebo-Controlled Study of Inositol in Trichotillomania Completed NCT01875445 Phase 2 Inositol;Placebo
11 An Open-Label Study of Dronabinol, a Cannabinoid Agonist, for Obsessive Compulsive Disorder and the Obsessive-Compulsive Spectrum Disorders Trichotillomania and Pathological Skin Picking Completed NCT01093976 Phase 2 Dronabinol
12 A Phase 2, Double Blind, Placebo-Controlled Study to Explore the Safety, Tolerability, and Activity of SXC-2023 in Adults With Moderate to Severe Trichotillomania (TTM) When Dosed for 6 Weeks Completed NCT03797521 Phase 2 SXC-2023;Placebo
13 Double-Blind, Placebo-Controlled Trial of N-acetylcysteine for the Treatment of Pediatric Trichotillomania Completed NCT00993265 Phase 2 N-Acetylcysteine;Placebo
14 A Double-blind, Placebo-controlled Study of Naltrexone in Trichotillomania Completed NCT00775229 Phase 2 Naltrexone;Placebo
15 Group Treatment for Trichotillomania: Cognitive-Behavioral Therapy Versus Supportive Therapy Completed NCT01968343 Phase 2
16 Cognitive Behavioral Therapy for Trichotillomania Completed NCT00740909 Phase 1, Phase 2
17 A Double-Blind, Placebo-Controlled Study of Memantine in Body Focused Repetitive Behaviors Not yet recruiting NCT04792645 Phase 2 Placebo;Memantine
18 Self-control Intervention to Increase Adherence to Web-based Self-help for Body-focused Repetitive Behaviors Active, not recruiting NCT04455152 Phase 1
19 The Norwegian Trichotillomania Project Unknown status NCT02747771
20 Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals in a General Hospital Setting Unknown status NCT01075672
21 Cognitive Training in Patients With Trichotillomania (Hair-pulling Disorder) Unknown status NCT02794753
22 Telepsychotherapy for the Treatment of Adolescents With Trichotillomania Unknown status NCT03725163
23 Decoupling as Internet Based Intervention: an Randomized Controlled Study to Treat Trichotillomania Completed NCT02044237
24 Developing Online Response Inhibition Training for Individuals With Trichotillomania Completed NCT01984333
25 Open Label Trial of Aripiprazole in Trichotillomania. Completed NCT00947154 aripiprazole
26 Feasibility Study for Treating Trichotillomania With Wearable Device and App System Using Habit Reversal Training Completed NCT04241120
27 Behavior Therapy for Pediatric Trichotillomania Completed NCT00917098
28 Cognitive Behavioral Treatment of Pediatric Trichotillomania Completed NCT00043563
29 Treatment Development Study of the COMB Model of Trichotillomania Completed NCT01878110
30 Habit Reversal Training for Children and Adolescents With Trichotillomania: A Controlled Trial Completed NCT01445444
31 Testing the Feasibility of Response Inhibition Enhancement Training for Individuals With Trichotillomania Completed NCT01638975
32 Randomized Controlled Trial of the Comprehensive Behavioral (ComB) Model of Treatment for Trichotillomania Completed NCT03486041
33 Developing Effective Response Inhibition Training for Symptom Relief in Obsessive-Compulsive and Related Disorders and Trichotillomania Completed NCT02059980
34 Evaluation of a Brief "Surf the Urge" Intervention Completed NCT02771886
35 The Evaluation and Follow-up of Patients With Obsessive-Compulsive Disorder and OC Spectrum Disorders Completed NCT00004550
36 Internet Delivered Cognitive Behavior Therapy for Trichotillomania and Skin Picking Disorder Recruiting NCT04559750

Search NIH Clinical Center for Trichotillomania

Cochrane evidence based reviews: trichotillomania

Sources

Genetic Tests for Trichotillomania

About this section

Genetic tests related to Trichotillomania:

# Genetic test Affiliating Genes
1 Trichotillomania 29 SLITRK1
Sources

Anatomical Context for Trichotillomania

About this section

MalaCards organs/tissues related to Trichotillomania:

40
Skin, Colon, Ovary, Subthalamic Nucleus
Sources

Publications for Trichotillomania

About this section

Articles related to Trichotillomania:

(show top 50) (show all 1213)
# Title Authors PMID Year
1
A twin concordance study of trichotillomania. 57 61
19199280 2009
2
Hoxb8 is required for normal grooming behavior in mice. 61 57
11779477 2002
3
Familial trichotillomania. 61 57
2018177 1991
4
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. 57
17713528 2007
5
Sequence variants in SLITRK1 are associated with Tourette's syndrome. 57
16224024 2005
6
Shared and unique neural mechanisms underlying pediatric trichotillomania and obsessive compulsive disorder. 61
33621723 2021
7
Common causes of hair loss - clinical manifestations, trichoscopy and therapy. 61
33290611 2021
8
Trichobezoar from bristles brush and Carpet yarn requiring emergency laparotomy. Case report. 61
33680452 2021
9
A huge abdominal mass revealing a depressive syndrome. 61
33645270 2021
10
From biosociality to biosolidarity: the looping effects of finding and forming social networks for body-focused repetitive behaviours. 61
33615913 2021
11
Cognitive Inflexibility in OCD and Related Disorders. 61
33547598 2021
12
Genetics of OCD and Related Disorders; Searching for Shared Factors. 61
33547599 2021
13
Sleep quality and its clinical associations in trichotillomania and skin picking disorder. 61
33395591 2021
14
Trichotillomania Incognito: Two Case Reports and Literature Review. 61
33796560 2021
15
Trichotillomania in Children and the Different Approaches between Dermatological and Behavioral Health Professionals at an Urban Tertiary Care Center. 61
33614710 2021
16
Hair-pulling disorder (Trichotillomania): Etiopathogenesis, diagnosis and treatment in a nutshell. 61
33015928 2021
17
Sex Differences in Age at Onset and Presentation of Trichotillomania and Trichobezoar: A 120-Year Systematic Review of Cases. 61
33420536 2021
18
Cognitive Functioning in Trichotillomania Across the Lifespan. 61
33279733 2021
19
Trichotillomania due to pica in a 23-month-old patient with concomitant iron deficiency anemia and lead poisoning. 61
33364276 2021
20
Psychodermatology knowledge and awareness in Chinese dermatologists: Results of a survey study. 61
33314566 2021
21
Gender Differences in Psychological Symptoms and Psychotherapeutic Processes in Japanese Children. 61
33291280 2020
22
White matter volume alterations in hair-pulling disorder (trichotillomania). 61
31376114 2020
23
Sensory symptoms in body-focused repetitive behaviors, restless legs syndrome, and Tourette syndrome: An overlap? 61
33086129 2020
24
Acceptance and Commitment Therapy: A Systematic Literature Review of Prevention and Intervention Programs for Mental Health Difficulties in Children and Young People. 61
33372124 2020
25
Repetitive Transcranial Magnetic Stimulation for Treatment of Trichotillomania: Case Series. 61
33124597 2020
26
Identifying subtypes of trichotillomania (hair pulling disorder) and excoriation (skin picking) disorder using mixture modeling in a multicenter sample. 61
33172654 2020
27
The Influence of Hair Pulling Styles in the Treatment of Trichotillomania. 61
33051032 2020
28
Recent advances in the treatment of trichotillomania (hair-pulling disorder). 61
32531098 2020
29
Awareness of psychodermatology in Indian dermatologists: A South Indian perspective. 61
32677246 2020
30
Multiple small bowel perforation in a young adult female due to Rapunzel Syndrome. 61
33170155 2020
31
Trichobezoar. 61
33231405 2020
32
Insights into recurrent body-focused repetitive behaviors: evidenced by New York Times commenters. 61
32078025 2020
33
Role of Bupropion and Naltrexone in Managing Depression With Polycystic Ovary Syndrome: A Case Report and Literature Review. 61
33304679 2020
34
Gastric trichobezoar in an end-stage renal failure and mental health disorder presented with chronic epigastric pain: A case report. 61
32953103 2020
35
Trichoscopic evaluation of frontal hairline recession in Egyptian female patients. 61
32048427 2020
36
[Classification of obsessivecompulsive disorder: evolution in the DSM-V]. 61
33739726 2020
37
Early-onset Trichotillomania with Habit Disorder in a 5-Year-Old-Girl - With Trichoscopic Findings. 61
33531748 2020
38
Lisdexamfetamine-Associated Tonsure Trichotillomania. 61
32932388 2020
39
Skin picking treatment with the Rothbaum cognitive behavioral therapy protocol: a randomized clinical trial. 61
32401873 2020
40
Gender Differences in Impulse Control Disorders and Related Behaviors in Patients with Parkinson's Disease and its Impact on Quality of Life. 61
33623263 2020
41
Sleep in obsessive-compulsive and related disorders: a selective review and synthesis. 61
31539831 2020
42
Neurochemical correlates of behavioral treatment of pediatric trichotillomania. 61
32560953 2020
43
Pharmacological and behavioral treatment for trichotillomania: An updated systematic review with meta-analysis. 61
32390221 2020
44
Pharmacotherapy for trichotillomania in adults. 61
32633577 2020
45
Mental Disorders: Obsessive-Compulsive Disorder and Body Dysmorphic Disorder. 61
32757562 2020
46
Nonpharmacological treatment approach in trichotillomania (hair-pulling disorder). 61
32430952 2020
47
Dupilumab therapy rapidly improved alopecia areata associated with trichotillomania in an atopic dermatitis patient. 61
32234288 2020
48
Measuring Treatment Response in Pediatric Trichotillomania: A Meta-Analysis of Clinical Trials. 61
31794677 2020
49
Trichoscopic findings of trichotillomania: new observations. 61
32792873 2020
50
Prevalence, gender correlates, and co-morbidity of trichotillomania. 61
32334275 2020
Sources

Variations for Trichotillomania

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ClinVar genetic disease variations for Trichotillomania:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SLITRK1 NM_001281503.2(SLITRK1):c.1264del (p.Leu422fs) Deletion Pathogenic 1578 rs193302861 GRCh37: 13:84454379-84454379
GRCh38: 13:83880244-83880244
2 SLITRK1 NM_001281503.2(SLITRK1):c.707T>C (p.Ile236Thr) SNV Uncertain significance 1030106 GRCh37: 13:84454936-84454936
GRCh38: 13:83880801-83880801
Sources

Expression for Trichotillomania

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Search GEO for disease gene expression data for Trichotillomania.
Sources

Pathways for Trichotillomania

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Pathways related to Trichotillomania according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Transmission across Chemical Synapses 65
Show member pathways
 12.51 SLC1A1 MAOA DLGAP3 DLGAP1 DLG4
2
Neuroscience 4
11.99 SLC1A1 GRM2 DLGAP1 DLG4
3
Circadian entrainment 36
Show member pathways
 11.77 SLC1A1 MAOA GRM2 DRD4 DLGAP1 DLG4
4
Protein-protein interactions at synapses 65
Show member pathways
 11.61 DLGAP3 DLGAP1 DLG4
5
Amphetamine addiction 36
Show member pathways
 11.2 MAOA GRM2 DLG4
6
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.73 MAOA DRD4
Sources

GO Terms for Trichotillomania

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Cellular components related to Trichotillomania according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.14 SLITRK5 SLITRK3 SLITRK2 SLITRK1 SLC1A1 SIGLEC5
2 cell junction GO:0030054 9.85 SLITRK1 SLC1A1 GRM2 DLGAP3 DLGAP1 DLG4
3 GABA-ergic synapse GO:0098982 9.5 SLITRK3 SLITRK2 SLITRK1
4 synapse GO:0045202 9.5 SLITRK5 SLITRK1 SLC1A1 GRM2 DLGAP3 DLGAP1
5 integral component of postsynaptic membrane GO:0099055 9.33 SLITRK3 SLITRK2 GRM2
6 postsynaptic specialization GO:0099572 9.26 DLGAP3 DLGAP1
7 glutamatergic synapse GO:0098978 9.1 SLITRK2 SLITRK1 DRD4 DLGAP3 DLGAP1 DLG4

Biological processes related to Trichotillomania according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 axonogenesis GO:0007409 9.56 SLITRK5 SLITRK3 SLITRK2 SLITRK1
2 adult behavior GO:0030534 9.52 SLITRK5 SLITRK1
3 glutamate secretion GO:0014047 9.51 SLC1A1 GRM2
4 synaptic membrane adhesion GO:0099560 9.5 SLITRK3 SLITRK2 SLITRK1
5 behavioral fear response GO:0001662 9.49 SLC1A1 DRD4
6 regulation of synapse organization GO:0050807 9.48 SLITRK2 SLITRK1
7 regulation of postsynaptic neurotransmitter receptor activity GO:0098962 9.46 DLGAP3 DLGAP1
8 positive regulation of synapse assembly GO:0051965 9.46 SLITRK5 SLITRK3 SLITRK2 SLITRK1
9 grooming behavior GO:0007625 9.43 SLITRK5 HOXB8
10 chemical synaptic transmission GO:0007268 9.43 SLITRK5 SLC1A1 GRM2 DRD4 DLGAP1 DLG4
11 signaling GO:0023052 9.4 DLGAP3 DLGAP1
12 glutamate homeostasis GO:0090461 9.37 SLC1A1 GRM2
13 regulation of presynapse assembly GO:1905606 8.92 SLITRK5 SLITRK3 SLITRK2 SLITRK1
Sources

Sources for Trichotillomania

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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