Trichotillomania disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TRC010 MIFTS: 46	Trichotillomania Categories: Genetic diseases, Rare diseases, Mental diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Download Expand all tables

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Aliases & Classifications for Trichotillomania

MalaCards integrated aliases for Trichotillomania:

Name: Trichotillomania ⁵⁷ ¹² ⁷⁶ ⁵³ ⁷⁵ ³⁷ ¹³ ⁴⁴ ¹⁵ ⁴⁰ ⁷³

Hair-Pulling ²⁹ ⁶

Ttm ⁵⁷ ⁷⁵

Hair-Pulling Syndrome ⁵³

Characteristics:

OMIM:

⁵⁷

Inheritance:
autosomal dominant
multifactorial

Miscellaneous:
affected individuals can pull hair from any part of the body, including eyelashes and eyebrows
overlap with obsessive-compulsive disorder (ocd, )
overlap with tourette syndrome
affects 1 to 3% of the population
one patient reported with slitrk1 mutation (as of january 2010)

HPO:

³²

trichotillomania:
Inheritance autosomal dominant inheritance multifactorial inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Mental diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Mental and behavioural disorders

Disorders of adult personality and behaviour

Habit and impulse disorders

Trichotillomania

External Ids:

OMIM ⁵⁷ 613229

Disease Ontology ¹² DOID:0050587

MedGen ⁴² C0040953 CN035643

MeSH ⁴⁴ D014256

KEGG ³⁷ H00864

ICD10 ³³ F63.3

SNOMED-CT via HPO ⁶⁹ 263681008 12479006 191736004 more

UMLS ⁷³ C0040953

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Summaries for Trichotillomania

NIH Rare Diseases : ⁵³ Trichotillomania is a disorder characterized by an overwhelming urge to repeatedly pull out one's own hair, resulting in hair loss (alopecia). It is classified under the obsessive-compulsive and related disorders category. Trichotillomania results in highly variable patterns of hair loss. The scalp is the most common area of hair pulling, followed by the eyebrows, eyelashes, pubic and perirectal areas, axillae, limbs, torso, and face. The resulting alopecia can range from thin unnoticeable areas of hair loss to total baldness. Some people chew or swallow the hair they pull out (trichophagy), which can result in gastrointestinal problems or develop a trichobezoar (hairball in the intestines or stomach). In many cases, people with this disorder feel extreme tension when they feel an impulse, followed by relief, gratification or pleasure afterwards. The disorder may be mild and manageable, or severe and debilitating. The cause is unknown, though both environmental and genetic causes have been suspected. Treatment may involve cognitive behavior therapy, such as habit reversal training (learning to substitute the hair-pulling behavior) and/or drug therapy, but these are not always effective.

MalaCards based summary : Trichotillomania, also known as hair-pulling, is related to impulse control disorder and obsessive-compulsive disorder. An important gene associated with Trichotillomania is SLITRK1 (SLIT And NTRK Like Family Member 1). The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotypes are obsessive-compulsive behavior and alopecia

Disease Ontology : ¹² An impulse control disorder that involves the uncontrollable plucking of ones hair.

OMIM : ⁵⁷ Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Tourette syndrome (GTS; 137580) or obsessive-compulsive disorder (OCD; 164230) (review by Novak et al., 2009). (613229)

UniProtKB/Swiss-Prot : ⁷⁵ Trichotillomania: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder.

Wikipedia : ⁷⁶ Trichotillomania (TTM), also known as hair pulling disorder, is an impulse control disorder... more...

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Related Diseases for Trichotillomania

Diseases related to Trichotillomania via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)

#	Related Disease	Score	Top Affiliating Genes
1	impulse control disorder	28.4	CLNK DLGAP3 SLITRK1
2	obsessive-compulsive disorder	28.3	DLGAP3 PRL SLITRK1 SLITRK5
3	stereotypic movement disorder	28.0	ABCB6 CLNK PRL SLITRK1
4	alopecia	10.3
5	alopecia areata	10.2
6	anxiety	10.1
7	depression	10.1
8	aging	10.1
9	bipolar disorder	10.1
10	attention deficit-hyperactivity disorder	10.0
11	dementia	10.0
12	movement disease	10.0
13	anorexia nervosa	9.9
14	tic disorder	9.9
15	cardiac arrest	9.9
16	angiomyolipoma	9.9
17	kidney angiomyolipoma	9.9
18	autism	9.8
19	celiac disease 1	9.8
20	alexithymia	9.8
21	body dysmorphic disorder	9.8
22	generalized anxiety disorder	9.8
23	dermatitis	9.8
24	kleptomania	9.8	ABCB6 SLITRK1
25	gilles de la tourette syndrome	9.7
26	huntington disease	9.7
27	monilethrix	9.7
28	schizophrenia	9.7
29	frontotemporal dementia	9.7
30	restless legs syndrome	9.7
31	autism spectrum disorder	9.7
32	chronic tic disorder	9.7
33	typhoid fever	9.7
34	post-traumatic stress disorder	9.7
35	cerebritis	9.7
36	tinea capitis	9.7
37	eating disorder	9.7
38	vascular dementia	9.7
39	neurotic excoriation	9.7
40	alopecia totalis	9.7
41	frontotemporal dementia with parkinsonism-17	9.7
42	paraphilia disorder	9.6	ABCB6 PRL
43	follicular mucinosis	9.6	DLGAP3 SLITRK1

Graphical network of the top 20 diseases related to Trichotillomania:

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Symptoms & Phenotypes for Trichotillomania

Symptoms via clinical synopsis from OMIM:

⁵⁷

Skin Nails Hair Hair:
alopecia resulting from compulsive hair pulling

Neurologic Behavioral Psychiatric Manifestations:
hair pulling, chronic, compulsive, repetitive
distress and functional impairment resulting from hair pulling behavior

Clinical features from OMIM:

613229

Human phenotypes related to Trichotillomania:

³²

#	Description	HPO Source Accession
1	obsessive-compulsive behavior ³²	HP:0000722
2	alopecia ³²	HP:0001596
3	hair-pulling ³²	HP:0012167

MGI Mouse Phenotypes related to Trichotillomania:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	8.92	ABCB6 DLGAP3 PRL SLITRK5

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Drugs & Therapeutics for Trichotillomania

Drugs for Trichotillomania (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dopamine

Approved

Phase 4,Phase 3

51-61-6, 62-31-7

681

Methylphenidate

Approved, Investigational

Phase 4

113-45-1

4158

Olanzapine

Approved, Investigational

Phase 4

132539-06-1

4585

Sertraline

Approved

Phase 4

79617-96-2

68617

Central Nervous System Stimulants

Phase 4

Dopamine Agents

Phase 4,Phase 3

Dopamine Uptake Inhibitors

Phase 4

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2

Neurotransmitter Uptake Inhibitors

Phase 4

Antiemetics

Phase 4

Antipsychotic Agents

Phase 4,Not Applicable

Autonomic Agents

Phase 4

Central Nervous System Depressants

Phase 4,Phase 2,Not Applicable

Gastrointestinal Agents

Phase 4

Peripheral Nervous System Agents

Phase 4,Phase 2

Psychotropic Drugs

Phase 4,Phase 2,Not Applicable

Serotonin Agents

Phase 4

Serotonin Uptake Inhibitors

Phase 4

Tranquilizing Agents

Phase 4,Not Applicable

Antidepressive Agents

Phase 4,Phase 2

Serotonin

Investigational, Nutraceutical

Phase 4

50-67-9

5202

Carbidopa

Approved

Phase 3

28860-95-9

34359 38101

Levodopa

Approved

Phase 3

59-92-7

6047

Adjuvants, Immunologic

Phase 3

Antiparkinson Agents

Phase 3

Aromatic Amino Acid Decarboxylase Inhibitors

Phase 3

Carbidopa, levodopa drug combination

Phase 3

Dopamine agonists

Phase 3

Acetylcysteine

Approved, Investigational

Phase 2,Not Applicable

616-91-1

12035

Naltrexone

Approved, Investigational, Vet_approved

Phase 2

16590-41-3

5360515

Dronabinol

Approved, Illicit

Phase 2

1972-08-3

16078

Ketamine

Approved, Vet_approved

Phase 2

6740-88-1

3821

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

Glutamic Acid

Approved, Nutraceutical

Phase 2

56-86-0

33032

Vitamin B Complex

Phase 2

Micronutrients

Phase 2

Trace Elements

Phase 2

Vitamins

Phase 2

Antidotes

Phase 2,Not Applicable

Anti-Infective Agents

Phase 2,Not Applicable

Antioxidants

Phase 2,Not Applicable

Antiviral Agents

Phase 2,Not Applicable

Expectorants

Phase 2,Not Applicable

N-monoacetylcystine

Phase 2,Not Applicable

Protective Agents

Phase 2,Not Applicable

Respiratory System Agents

Phase 2,Not Applicable

Narcotic Antagonists

Phase 2

Narcotics

Phase 2

Analgesics

Phase 2

Interventional clinical trials:

(show all 45)

#	Name	Status	NCT ID	Phase	Drugs
1	Methylphenidate in ADHD With Trichotillomania	Unknown status	NCT00552266	Phase 4	Methylphenidate
2	Olanzapine in the Treatment of Hair Pulling (Trichotillomania)	Completed	NCT00182507	Phase 4	Olanzapine
3	Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania	Completed	NCT00118014	Phase 4	Sertraline
4	Safety/Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Parkinson's Subjects	Completed	NCT00360568	Phase 3	Levodopa-carbidopa intestinal gel
5	Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease	Completed	NCT00335153	Phase 3	Levodopa-carbidopa intestinal gel
6	Dronabinol in Trichotillomania	Not yet recruiting	NCT03530800	Phase 2, Phase 3	Dronabinol;Placebo
7	Testing a New Therapy for Trichotillomania	Unknown status	NCT00872742	Phase 2
8	Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania	Completed	NCT01654523	Phase 2
9	Inositol in Trichotillomania	Completed	NCT01875445	Phase 2	Inositol;Placebo
10	Trichotillomania: Group Cognitive-Behavioral Therapy	Completed	NCT01968343	Phase 2
11	N-Acetylcysteine for Pediatric Trichotillomania	Completed	NCT00993265	Phase 2	N-Acetylcysteine;Placebo
12	Naltrexone in the Treatment of Trichotillomania	Completed	NCT00775229	Phase 2	Naltrexone;Placebo
13	Stepped Care in the Treatment of Trichotillomania	Completed	NCT01118637	Phase 2
14	N-Acetyl Cysteine in Trichotillomania	Completed	NCT00354770	Phase 2	Placebo;N-Acetyl Cysteine
15	Cognitive Behavioral Therapy for Trichotillomania	Completed	NCT00740909	Phase 1, Phase 2
16	Marinol in Trichotillomania or Obsessive Compulsive Disorder	Completed	NCT01093976	Phase 2	Dronabinol
17	N-acetylcysteine (NAC) for Children With Tourette Syndrome	Completed	NCT01172288	Phase 2	N-Acetylcysteine (NAC);Placebo
18	Ketamine Infusion for Obsessive-Compulsive Disorder	Completed	NCT01349231	Phase 2	ketamine
19	Milk Thistle in Trichotillomania in Children and Adults	Recruiting	NCT02473913	Phase 2	Milk Thistle;Placebo
20	Valchlor in the Treatment of Lichen Planopilaris	Recruiting	NCT03417141	Phase 2	Valchlor
21	N-acetylcysteine (NAC) for Pediatric Obsessive-Compulsive Disorder	Active, not recruiting	NCT01172275	Phase 2	N-Acetylcysteine;Placebo
22	Efficacy of Topical Gentamycin for Hereditary Hypotrichosis Simplex Caused by Nonsense Mutations in CDSN	Not yet recruiting	NCT03492866	Phase 2	Gentamicin Sulfate
23	Hair Fall in Patients on Low Dose Methotrexate	Unknown status	NCT02591823
24	Online Response Inhibition Training for Trichotillomania	Completed	NCT01984333	Not Applicable
25	Habit Reversal Training for Children and Adolescents With Trichotillomania	Completed	NCT01445444	Not Applicable
26	Trial of Aripiprazole in Trichotillomania	Completed	NCT00947154	Not Applicable	aripiprazole
27	Efficacy of COMB (Comprehensive Behavioral) Model of Treatment of Trichotillomania	Completed	NCT01878110	Not Applicable
28	Online Treatment of Trichotillomania	Completed	NCT02044237	Not Applicable
29	Response Inhibition Training for Individuals With Trichotillomania	Completed	NCT01638975	Not Applicable
30	Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania	Completed	NCT02059980	Not Applicable
31	Examining Behavior Therapy for Trichotillomania in Children and Adolescents	Completed	NCT00917098	Not Applicable
32	Cognitive Behavioral Treatment of Pediatric Trichotillomania	Completed	NCT00043563	Not Applicable
33	Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions	Completed	NCT00004550
34	Glutathione Levels and Compulsivity	Completed	NCT02794389	Not Applicable	N-acetyl cysteine;Placebo
35	Cortical Excitability in Obsessive-Compulsive and Related Disorders	Completed	NCT00029068
36	Evaluation of a Brief Surf the Urge Intervention	Completed	NCT02771886	Not Applicable
37	Genetics of Obsessive-Compulsive Disorder	Completed	NCT00001548
38	Comprehensive Behavioral (ComB) Model of Treatment for Trichotillomania	Recruiting	NCT03486041	Not Applicable
39	Cognitive Training in Patients With Trichotillomania (Hair-pulling Disorder)	Recruiting	NCT02794753	Not Applicable
40	Motor Control Mechanisms by CNS of Tuina in Patients With Lumbar Disk Herniation	Recruiting	NCT03475095	Not Applicable
41	Alcohol Related Impairment and Reinforcement: Pre to Post Roux en Y Gastric Bypass Surgery	Recruiting	NCT02370732	Not Applicable
42	Cognitive Behavioral Group Therapy for Trichotillomania (Hair Pulling Disorder)	Active, not recruiting	NCT02747771
43	Treating Skin Picking With Cognitive-Behavioral Protocol in Individual and Group Format.	Active, not recruiting	NCT03182478	Not Applicable
44	Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals	Active, not recruiting	NCT01075672	Not Applicable
45	Relevance of Trichoscopy in Differential Diagnosis of Focal Non-cicatricial Alopecia in Children	Not yet recruiting	NCT03260777

Search NIH Clinical Center for Trichotillomania

Cochrane evidence based reviews: trichotillomania

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Genetic Tests for Trichotillomania

Genetic tests related to Trichotillomania:

#	Genetic test	Affiliating Genes
1	Hair-Pulling ²⁹	SLITRK1

Sources

Anatomical Context for Trichotillomania

MalaCards organs/tissues related to Trichotillomania:

⁴¹

Skin, Eye, Testes, Brain

Sources

Publications for Trichotillomania

Articles related to Trichotillomania:

(show top 50) (show all 577)

#	Title	Authors	Year
1	Trichotillomania Ranging from &quot;Ritual to Illness&quot; and as a Rare Clinical Manifestation of Frontotemporal Dementia: Review of Literature and Case Report. ( 29769783 )	Issac T.G....Chandra S.R.	2018
2	Striatal abnormalities in trichotillomania: a multi-site MRI analysis. ( 29515968 )	Isobe M....Chamberlain S.R.	2018
3	Computerized response inhibition training for children with trichotillomania. ( 29407564 )	Lee H.J....Woods D.W.	2018
4	Clinical Characteristics and Comorbidity of Pediatric Trichotillomania: the Study of 38 Cases in Croatia. ( 29546862 )	KlobuA8ar A....GuliA8 L.	2018
5	Remote treatment of sleep-related trichotillomania and trichophagia. ( 29468679 )	Lichtblau K.R....Bragdon A.K.	2018
6	Atomoxetine in the Treatment of Adolescent With Trichotillomania and Attention-Deficit/Hyperactivity Disorder. ( 29533364 )	TA1rkoA9lu S....A8etin F.H.	2018
7	Trichotillomania ( 29630238 )	Pereyra A.D....Saadabadi A.	2018
8	Awareness Enhancing and Monitoring Device plus Habit Reversal in the Treatment of Trichotillomania: An Open Feasibility Trial. ( 29607291 )	Himle J.A....Rimer J.M.	2018
9	Salivary sex hormones in adolescent females with trichotillomania. ( 29753253 )	Grant J.E....Chamberlain S.R.	2018
10	Types of avoidance in hair-pulling disorder (trichotillomania): An exploratory and confirmatory analysis. ( 29306818 )	Slikboer R....Rossell S.L.	2018
11	Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania. ( 29682419 )	Casarotto P.C....Guimaraes F.S.	2018
12	The Dermoscopic &quot;Pluck Out Sign&quot; for Beard Trichotillomania. ( 29457007 )	Cutrone M....Grimalt R.	2018
13	Trichotillomania Associated With Aripiprazole: A Case Report. ( 29257789 )	ArgA1z A8ildir D....Kalyoncu T.	2018
14	Salivary Inflammatory Markers in Trichotillomania: A Pilot Study. ( 29920483 )	Grant J.E....Chamberlain S.R.	2018
15	Trichotillomania: the impact of treatment history on the outcome of an Internet-based intervention. ( 28461751 )	Weidt S....Rufer M.	2017
16	Trichotillomania and Bipolar Disorder. ( 28142271 )	Sharma V....Baczynski C.	2017
17	Trichoscopic clues for diagnosis of alopecia areata and trichotillomania in Asians. ( 28074524 )	Khunkhet S....Suchonwanit P.	2017
18	A double-blind, placebo-controlled study of inositol in trichotillomania. ( 27824633 )	Leppink E.W....Grant J.E.	2017
19	Trichotillomania in celiac disease patient refractory to iron replacement. ( 28779566 )	Kalyoncu T....A9zbaran B.	2017
20	Making sense of the role of sense organs in trichotillomania. ( 28827858 )	Kakunje A....Rao T.S.S.	2017
21	&quot;i hair&quot;: A prognostic marker in alopecia areata &amp; trichotillomania. ( 29263543 )	Malakar S....Mehta P.R.	2017
22	Systematic Review of Published Primary Studies of Neuropsychology and Neuroimaging in Trichotillomania. ( 28835311 )	Slikboer R....Rossell S.L.	2017
23	Cortical thickness abnormalities in trichotillomania: international multi-site analysis. ( 28664230 )	Chamberlain S.R....Grant J.E.	2017
24	Increased Trichotillomania Symptoms in a Child With Fluoxetine Treatment. ( 28118168 )	YektaA9 A.8....Tufan A.E.	2017
25	Pathological grooming: Evidence for a single factor behind trichotillomania, skin picking and nail biting. ( 28902896 )	Maraz A....Demetrovics Z.	2017
26	Pharmacotherapy of trichotillomania. ( 28440210 )	Sharma V.	2017
27	Trichotillomania: a case report with clinical and dermatoscopic differential diagnosis with alopecia areata. ( 28225970 )	Pinto A.C....Martelli A.C.	2017
28	Modified-Release Methylphenidate-Related Trichotillomania in a Boy with Autism Spectrum Disorder. ( 28394174 )	Gunes S.	2017
29	Refining Treatment Approaches in Comorbid Trichotillomania and Bipolar Disorder: Response to Sharma and Baczynski. ( 28142278 )	Grant J.E.	2017
30	A Preliminary Investigation of Metacognitive Therapy and Habit Reversal as a Treatment for Trichotillomania. ( 28903787 )	Shareh H.	2017
31	Trichotillomania and its clinical relationship to depression and anxiety. ( 28429625 )	Grant J.E....Keuthen N.J.	2017
32	Clarifying the Relationship between Trichotillomania and Anxiety. ( 28989859 )	Alexander J.R....Woods D.W.	2017
33	Burnt Matchstick Sign - A new Trichoscopic finding in Trichotillomania. ( 28761268 )	Malakar S....Mukherjee S.S.	2017
34	Videodermoscopy supports the diagnosis of eyelash trichotillomania. ( 28426900 )	SA8awiA8ska M....BaraA8ska-Rybak W.	2017
35	Trichotillomania in Attention-Deficit/Hyperactivity Disorder Under Methylphenidate Treatment. ( 28492426 )	Kara T....Akaltun A.^.	2017
36	Trichotillomania: a good response to treatment with N-acetylcysteine. ( 28954106 )	Barroso L.A.L....Nunes G.J.B.	2017
37	Preventing, treating, and predicting barbering: A fundamental role for biomarkers of oxidative stress in a mouse model of Trichotillomania. ( 28426681 )	Vieira G.L.T....Garner J.P.	2017
38	Atomoxetine-Related Trichotillomania in a Boy with Attention-Deficit/Hyperactivity Disorder. ( 29099621 )	Akaltun A.^....Kara T.	2017
39	Self-inflicted skin lesions and trichotillomania due to rolled hair. ( 28621120 )	Loi C....Patrizi A.	2017
40	&quot;The girl who pulled her hair&quot;-Positive-affect trichotillomania in a 2-year old child. ( 28784383 )	Mitra S....Yadav N.	2017
41	Predictors of comorbid eating disorders and association with other obsessive-compulsive spectrum disorders in trichotillomania. ( 28667830 )	Greenberg E....Keuthen N.J.	2017
42	Exposure and Ritual Prevention Therapy for Trichotillomania: Two Case Reports. ( 29099553 )	Brauer L....Grant J.E.	2017
43	Trichotillomania and co-occurring anxiety. ( 27668531 )	Grant J.E....Chamberlain S.R.	2017
44	Sensory over-responsivity in trichotillomania (hair-pulling disorder). ( 29202385 )	Falkenstein M.J....Haaga D.A.F.	2017
45	Placebo response in trichotillomania. ( 28628502 )	Grant J.E....Kim S.W.	2017
46	Trichotillomania and trichophagia - diagnosis, treatment, prevention. The attempt to establish guidelines of treatment in Poland. ( 27086333 )	GawA8owska-Sawosz M....WolaA8czyk T.	2016
47	Affective correlates of trichotillomania across the pulling cycle: Findings from an Italian sample of self-identified hair pullers. ( 27836242 )	Bottesi G....Ghisi M.	2016
48	Trichobezoar (Rapunzel syndrome) in an adolescent patient with Trichotillomania and Generalized Anxiety Disorder: A case report. ( 27969077 )	Kumar Bn A....Rangaswamaiah L.N.	2016
49	Review of available studies of the neurobiology and pharmacotherapeutic management of trichotillomania. ( 26966559 )	Johnson J....El-Alfy A.T.	2016
50	Comprehensive Behavioral Treatment of Trichotillomania: A Treatment Development Study. ( 26643276 )	Falkenstein M.J....Haaga D.A.	2016

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Genes for Trichotillomania

Genes related to Trichotillomania (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SLITRK1	SLIT And NTRK Like Family Member 1	Protein Coding	1096.09	Molecular basis known ⁵⁷ Pathogenic ⁶ Genetic Tests ²⁹ Unconfirmed association ⁵⁷ DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)	16224024
2	DLGAP3	DLG Associated Protein 3	Protein Coding	24.73	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	PRL	Prolactin	Protein Coding	16.89	GeneCards inferred via : Publications (show sections)
4	CLNK	Cytokine Dependent Hematopoietic Cell Linker	Protein Coding	16.66	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	SLITRK5	SLIT And NTRK Like Family Member 5	Protein Coding	15.42	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	ABCB6	ATP Binding Cassette Subfamily B Member 6 (Langereis Blood Group)	Protein Coding	15.06	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

Sources

Variations for Trichotillomania

ClinVar genetic disease variations for Trichotillomania:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	SLITRK1	NM_052910.2(SLITRK1): c.1264delC (p.Leu422Phefs)	deletion	Pathogenic	rs193302861	GRCh37	Chromosome 13, 84454379: 84454379
2	SLITRK1	NM_052910.2(SLITRK1): c.1264delC (p.Leu422Phefs)	deletion	Pathogenic	rs193302861	GRCh38	Chromosome 13, 83880244: 83880244

Sources

Expression for Trichotillomania

Search GEO for disease gene expression data for Trichotillomania.

Sources

Pathways for Trichotillomania

Sources

GO Terms for Trichotillomania

Biological processes related to Trichotillomania according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	axonogenesis	GO:0007409	9.26	SLITRK1 SLITRK5
2	positive regulation of synapse assembly	GO:0051965	9.16	SLITRK1 SLITRK5
3	skin development	GO:0043588	8.96	ABCB6 SLITRK5
4	adult behavior	GO:0030534	8.62	SLITRK1 SLITRK5

Sources

Sources for Trichotillomania

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia