TTM
MCID: TRC010
MIFTS: 51

Trichotillomania (TTM)

Categories: Gastrointestinal diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Trichotillomania

MalaCards integrated aliases for Trichotillomania:

Name: Trichotillomania 56 12 74 52 73 36 29 13 6 43 15 39 71 32
Ttm 56 73
Hair-Pulling Syndrome 52

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant
multifactorial

Miscellaneous:
affected individuals can pull hair from any part of the body, including eyelashes and eyebrows
overlap with obsessive-compulsive disorder (ocd, )
overlap with tourette syndrome
affects 1 to 3% of the population
one patient reported with slitrk1 mutation (as of january 2010)


HPO:

31

Classifications:



External Ids:

Disease Ontology 12 DOID:0050587
OMIM 56 613229
KEGG 36 H00864
MeSH 43 D014256
ICD10 32 F63.3
UMLS 71 C0040953

Summaries for Trichotillomania

NIH Rare Diseases : 52 Trichotillomania is a disorder characterized by an overwhelming urge to repeatedly pull out one's own hair, resulting in hair loss (alopecia ). It is classified under the obsessive-compulsive and related disorders category. Trichotillomania results in highly variable patterns of hair loss. The scalp is the most common area of hair pulling, followed by the eyebrows, eyelashes, pubic and perirectal areas, axillae, limbs, torso, and face. The resulting alopecia can range from thin unnoticeable areas of hair loss to total baldness. Some people chew or swallow the hair they pull out (trichophagy), which can result in gastrointestinal problems or develop a trichobezoar (hairball in the intestines or stomach). In many cases, people with this disorder feel extreme tension when they feel an impulse, followed by relief, gratification or pleasure afterwards. The disorder may be mild and manageable, or severe and debilitating. The cause is unknown, though both environmental and genetic causes have been suspected. Treatment may involve cognitive behavior therapy , such as habit reversal training (learning to substitute the hair-pulling behavior) and/or drug therapy, but these are not always effective.

MalaCards based summary : Trichotillomania, also known as ttm, is related to stereotypic movement disorder and loose anagen hair syndrome. An important gene associated with Trichotillomania is SLITRK1 (SLIT And NTRK Like Family Member 1), and among its related pathways/superpathways are Circadian entrainment and Monoamine GPCRs. The drugs Methylphenidate and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and brain, and related phenotypes are alopecia and obsessive-compulsive behavior

Disease Ontology : 12 An impulse control disorder that involves the uncontrollable plucking of ones hair.

OMIM : 56 Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Tourette syndrome (GTS; 137580) or obsessive-compulsive disorder (OCD; 164230) (review by Novak et al., 2009). (613229)

KEGG : 36 Trichotillomania (TTM) is a chronic behavioral disorder characterized by the irresistible urge to pull out one's hair, resulting in noticeable hair loss. Mutations in SLITRK1 are found in patients with TTM.

UniProtKB/Swiss-Prot : 73 Trichotillomania: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder.

Wikipedia : 74 Trichotillomania (TTM), also known as hair pulling disorder or compulsive hair pulling, is a mental... more...

Related Diseases for Trichotillomania

Diseases related to Trichotillomania via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 stereotypic movement disorder 30.7 SLITRK1 PRL CLNK
2 loose anagen hair syndrome 30.6 SLITRK1 DLGAP3
3 pyromania 30.4 SLITRK1 DRD2
4 body dysmorphic disorder 30.2 SLITRK5 SLITRK1 SLC1A1 HOXB8 DLGAP3
5 tinea capitis 30.1 SLITRK1 LPP
6 obsessive-compulsive personality disorder 30.0 SLITRK1 DRD3
7 eating disorder 29.9 DRD3 DRD2 DLGAP1
8 bulimia nervosa 29.9 PRL DRD4 DRD2
9 personality disorder 29.7 PRL DRD4 DRD3 DRD2
10 telogen effluvium 29.7 SLITRK1 LPP DLGAP3
11 anxiety 29.6 SLC1A1 PRL DRD4 DRD3 DRD2
12 attention deficit-hyperactivity disorder 29.5 PRL DRD4 DRD3 DRD2 DLGAP1
13 mental depression 29.5 MIR24-1 DRD4 DRD3 DRD2
14 pathological gambling 29.4 DRD4 DRD3 DRD2
15 choreatic disease 29.4 DRD4 DRD3 DRD2
16 substance abuse 29.4 PRL DRD4 DRD3 DRD2
17 kleptomania 29.3 SLITRK1 DRD4 DRD3 DRD2 DLGAP3
18 movement disease 29.3 DRD4 DRD3 DRD2
19 obsessive-compulsive disorder 29.2 SLITRK5 SLITRK1 SLC1A1 PRL DRD4 DRD3
20 bipolar disorder 29.1 SLC1A1 PRL KDM4C DRD4 DRD3 DRD2
21 restless legs syndrome 29.1 PRL DRD4 DRD3 DRD2
22 panic disorder 29.1 PRL DRD4 DRD3 DRD2
23 major depressive disorder 29.1 PRL DRD4 DRD3 DRD2
24 tobacco addiction 29.1 DRD4 DRD3 DRD2
25 impulse control disorder 29.0 SLITRK5 SLITRK1 HOXB8 DRD4 DRD3 DRD2
26 alcohol dependence 28.9 PRL DRD4 DRD3 DRD2
27 autism 28.7 SLC1A1 PRL KDM4C DRD4 DRD3 DRD2
28 tic disorder 28.7 SLITRK5 SLITRK1 SLC1A1 MIR24-1 DRD4 DRD3
29 gilles de la tourette syndrome 28.5 SLITRK5 SLITRK1 MIR24-1 DRD4 DRD3 DRD2
30 autism spectrum disorder 28.4 SLITRK2 SLC1A1 DRD4 DRD3 DRD2
31 alopecia 10.8
32 cardiac arrest 10.8
33 alopecia areata 10.6
34 depression 10.4
35 major affective disorder 8 10.4
36 major affective disorder 9 10.4
37 leukemia, chronic lymphocytic 10.3
38 ischemia 10.2
39 back pain 10.2
40 pik3ca-related overgrowth syndrome 10.2
41 neurotic disorder 10.2
42 dermatophytosis 10.2
43 transient tic disorder 10.2 DRD4 DLGAP1
44 galactorrhea 10.2 PRL DRD2
45 dicarboxylic aminoaciduria 10.2 SLITRK5 SLC1A1 DLGAP3
46 prolactin producing pituitary tumor 10.2 PRL DRD2
47 dementia 10.2
48 generalized anxiety disorder 10.2
49 dermatitis 10.2
50 intermittent explosive disorder 10.1 SLITRK1 DRD2

Graphical network of the top 20 diseases related to Trichotillomania:



Diseases related to Trichotillomania

Symptoms & Phenotypes for Trichotillomania

Human phenotypes related to Trichotillomania:

31
# Description HPO Frequency HPO Source Accession
1 alopecia 31 HP:0001596
2 obsessive-compulsive behavior 31 HP:0000722
3 hair-pulling 31 HP:0012167

Symptoms via clinical synopsis from OMIM:

56
Skin Nails Hair Hair:
alopecia resulting from compulsive hair pulling

Neurologic Behavioral Psychiatric Manifestations:
hair pulling, chronic, compulsive, repetitive
distress and functional impairment resulting from hair pulling behavior

Clinical features from OMIM:

613229

GenomeRNAi Phenotypes related to Trichotillomania according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.5 LPP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.5 LPP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.5 DRD4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 9.5 DRD3 LPP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.5 DRD3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-159 9.5 DRD3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-166 9.5 DRD3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-196 9.5 LPP
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.5 CLNK
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-51 9.5 DRD3
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.5 DRD3
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.5 DRD3
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 9.5 DRD3
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-88 9.5 LPP

MGI Mouse Phenotypes related to Trichotillomania:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 DLGAP1 DLGAP3 DRD2 DRD3 DRD4 HOXB8
2 nervous system MP:0003631 9.32 DLGAP3 DRD2 DRD3 DRD4 HOXB8 PRL

Drugs & Therapeutics for Trichotillomania

Drugs for Trichotillomania (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
2
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
3
Sertraline Approved Phase 4 79617-96-2 68617
4
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
5
Ondansetron Approved Phase 4 99614-02-5 4595
6
Minoxidil Approved, Investigational Phase 4 38304-91-5 4201
7
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
8 Central Nervous System Stimulants Phase 4
9 Serotonin Uptake Inhibitors Phase 4
10 Antidepressive Agents Phase 4
11 N-monoacetylcystine Phase 4
12 Neurotransmitter Agents Phase 4
13 Gastrointestinal Agents Phase 4
14 Antiemetics Phase 4
15 Psychotropic Drugs Phase 4
16 Antipsychotic Agents Phase 4
17 Anti-Anxiety Agents Phase 4
18 Dermatologic Agents Phase 4
19 Antihypertensive Agents Phase 4
20 Vasodilator Agents Phase 4
21
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
22
Dronabinol Approved, Illicit Phase 2, Phase 3 1972-08-3 16078
23 Hormones Phase 2, Phase 3
24 Analgesics, Non-Narcotic Phase 2, Phase 3
25 Hormone Antagonists Phase 2, Phase 3
26 Analgesics Phase 2, Phase 3
27 Hallucinogens Phase 2, Phase 3
28
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
29
Ethanol Approved Phase 2 64-17-5 702
30
Ketamine Approved, Vet_approved Phase 2 6740-88-1 3821
31
Milk thistle Approved, Experimental, Investigational Phase 2 65666-07-1
32
Glutamic acid Approved, Nutraceutical Phase 2 56-86-0 33032
33
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
34 Respiratory System Agents Phase 2
35 Anti-Infective Agents Phase 2
36 Antidotes Phase 2
37 Antiviral Agents Phase 2
38 Expectorants Phase 2
39 Narcotics Phase 2
40 Narcotic Antagonists Phase 2
41 Trace Elements Phase 2
42 Vitamins Phase 2
43 Vitamin B Complex Phase 2
44 Folate Phase 2
45 Nutrients Phase 2
46 Micronutrients Phase 2
47 Vitamin B9 Phase 2
48 Anesthetics Phase 2
49 Excitatory Amino Acid Antagonists Phase 2
50 Anesthetics, General Phase 2

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Methylphenidate Treatment of Children and Adolescents Diagnosed With ADHD and Its Influence on Comorbid Trichotillomania Unknown status NCT00552266 Phase 4 Methylphenidate
2 A 12-Week, Double-Blind Trial of Olanzapine and Placebo in the Treatment of Trichotillomania Completed NCT00182507 Phase 4 Olanzapine
3 Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania Completed NCT00118014 Phase 4 Sertraline
4 Effects of Ondansetron in Obsessive-compulsive and Tic Disorders Recruiting NCT03239210 Phase 4 Ondansetron;Placebo
5 Efficacy and Tolerability of N-Acetyl- Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men Recruiting NCT04209803 Phase 4 Minoxidil 5% topically and oral NAC 600 mg
6 A Double-Blind, Placebo-Controlled Study of Dronabinol in Trichotillomania and Other Body Focused Repetitive Behaviors Recruiting NCT03530800 Phase 2, Phase 3 Dronabinol;Placebo
7 Acceptance Enhanced Behavior Therapy for Trichotillomania Unknown status NCT00872742 Phase 2
8 A Double-Blind, Placebo-Controlled Study of N-Acetyl Cysteine in Trichotillomania Completed NCT00354770 Phase 2 Placebo;N-Acetyl Cysteine
9 Group Treatment for Trichotillomania: Cognitive-Behavioral Therapy Versus Supportive Therapy Completed NCT01968343 Phase 2
10 Double-Blind, Placebo-Controlled Trial of N-acetylcysteine for the Treatment of Pediatric Trichotillomania Completed NCT00993265 Phase 2 N-Acetylcysteine;Placebo
11 A Double-blind, Placebo-controlled Study of Naltrexone in Trichotillomania Completed NCT00775229 Phase 2 Naltrexone;Placebo
12 Cognitive Behavioral Therapy for Trichotillomania Completed NCT00740909 Phase 1, Phase 2
13 A Double-Blind, Placebo-Controlled Study of Inositol in Trichotillomania Completed NCT01875445 Phase 2 Inositol;Placebo
14 A Phase 2, Double Blind, Placebo-Controlled Study to Explore the Safety, Tolerability, and Activity of SXC-2023 in Adults With Moderate to Severe Trichotillomania (TTM) When Dosed for 6 Weeks Completed NCT03797521 Phase 2 SXC-2023;Placebo
15 Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania Completed NCT01654523 Phase 2
16 An Open-Label Study of Dronabinol, a Cannabinoid Agonist, for Obsessive Compulsive Disorder and the Obsessive-Compulsive Spectrum Disorders Trichotillomania and Pathological Skin Picking Completed NCT01093976 Phase 2 Dronabinol
17 Stepped Care in the Treatment of Trichotillomania Completed NCT01118637 Phase 2
18 Double-Blind, Placebo-Controlled Trial of N-acetylcysteine (NAC) for the Treatment of Pediatric Obsessive-Compulsive Disorder Completed NCT01172275 Phase 2 N-Acetylcysteine
19 Double-Blind, Placebo-Controlled Trial of N-acetylcysteine (NAC) for the Treatment of Children With Tourette Syndrome Completed NCT01172288 Phase 2 N-Acetylcysteine (NAC);Placebo
20 Ketamine Infusion for Obsessive-Compulsive Disorder Completed NCT01349231 Phase 2 ketamine
21 Silymarin Treatment of Trichotillomania in Children and Adults: A Double-Blind, Placebo-Controlled, Cross-Over Study Active, not recruiting NCT02473913 Phase 2 Milk Thistle;Placebo
22 Open-Trial of EPI-743 for Adults With Tourette Syndrome Completed NCT01719523 Phase 1 EPI-743
23 The Effects of Ondansetron on Brain Function Completed NCT02460341 Phase 1 ondansetron;placebo
24 The Norwegian Trichotillomania Project Unknown status NCT02747771
25 Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals in a General Hospital Setting Unknown status NCT01075672
26 Cognitive Training in Patients With Trichotillomania (Hair-pulling Disorder) Unknown status NCT02794753
27 Relevance of Trichoscopy in Differential Diagnosis of Focal Non-cicatricial Alopecia in Children Unknown status NCT03260777
28 Decoupling as Internet Based Intervention: an Randomized Controlled Study to Treat Trichotillomania Completed NCT02044237
29 Treatment Development Study of the COMB Model of Trichotillomania Completed NCT01878110
30 Feasibility Study for Treating Trichotillomania With Wearable Device and App System Using Habit Reversal Training Completed NCT04241120
31 Cognitive Behavioral Treatment of Pediatric Trichotillomania Completed NCT00043563
32 Developing Online Response Inhibition Training for Individuals With Trichotillomania Completed NCT01984333
33 Behavior Therapy for Pediatric Trichotillomania Completed NCT00917098
34 Developing Effective Response Inhibition Training for Symptom Relief in Obsessive-Compulsive and Related Disorders and Trichotillomania Completed NCT02059980
35 Habit Reversal Training for Children and Adolescents With Trichotillomania: A Controlled Trial Completed NCT01445444
36 Open Label Trial of Aripiprazole in Trichotillomania. Completed NCT00947154 aripiprazole
37 Testing the Feasibility of Response Inhibition Enhancement Training for Individuals With Trichotillomania Completed NCT01638975
38 Improving Skin Picking Treatment Using a Cognitive-Behavioral Protocol in Individual and Group Format: a Randomized Clinical Trial Completed NCT03182478
39 The Evaluation and Follow-up of Patients With Obsessive-Compulsive Disorder and OC Spectrum Disorders Completed NCT00004550
40 Genetics of Obsessive-Compulsive Disorder: A Collaborative Study Completed NCT00001548
41 Developing Treatments to Improve Psychosocial Functioning in Children With Williams Syndrome Part 1: Response Inhibition Training for Children With Williams Syndrome Completed NCT02212314
42 How do Glutathione Levels Affect Compulsivity? A Double-blind, Placebo-controlled Study Completed NCT02794389 N-acetyl cysteine;Placebo
43 Evaluation of a Brief "Surf the Urge" Intervention Completed NCT02771886
44 Studies of Cortical Excitability in Obsessive-Compulsive Disorder, Related Disorder and Healthy Volunteers Using Paired-Pulse Transcranial Magnetic Stimulation Completed NCT00029068
45 Randomized Controlled Trial of Group Psychodrama for Skin Picking Completed NCT03073135
46 Telepsychotherapy for the Treatment of Adolescents With Trichotillomania Recruiting NCT03725163
47 Randomized Controlled Trial of the Comprehensive Behavioral (ComB) Model of Treatment for Trichotillomania Active, not recruiting NCT03486041

Search NIH Clinical Center for Trichotillomania

Cochrane evidence based reviews: trichotillomania

Genetic Tests for Trichotillomania

Genetic tests related to Trichotillomania:

# Genetic test Affiliating Genes
1 Trichotillomania 29 SLITRK1

Anatomical Context for Trichotillomania

MalaCards organs/tissues related to Trichotillomania:

40
Skin, Eye, Brain, Testes, Small Intestine, Colon, Liver

Publications for Trichotillomania

Articles related to Trichotillomania:

(show top 50) (show all 1168)
# Title Authors PMID Year
1
Sequence variants in SLITRK1 are associated with Tourette's syndrome. 56 6
16224024 2005
2
A twin concordance study of trichotillomania. 56 61
19199280 2009
3
Hoxb8 is required for normal grooming behavior in mice. 56 61
11779477 2002
4
Familial trichotillomania. 61 56
2018177 1991
5
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. 56
17713528 2007
6
Neurochemical correlates of behavioral treatment of pediatric trichotillomania. 61
32560953 2020
7
Sleep in obsessive-compulsive and related disorders: a selective review and synthesis. 61
31539831 2020
8
Recent Advances in The Treatment of Trichotillomania (Hair Pulling Disorder). 61
32531098 2020
9
Prevalence, gender correlates, and co-morbidity of trichotillomania. 61
32334275 2020
10
Neuropsychiatric Aspects of Impulse Control Disorders. 61
32439020 2020
11
Psychodermatology in Balkans: Knowledge, awareness, and practice patterns of dermatologists in Albania. 61
32105382 2020
12
A Neurocognitive Comparison of Pediatric Obsessive-Compulsive Disorder and Trichotillomania (Hair Pulling Disorder). 61
32086728 2020
13
Memantine treatment of trichotillomania. 61
32343286 2020
14
Nonpharmacological treatment approach in trichotillomania (hair-pulling disorder). 61
32430952 2020
15
Novel inflammatory targets for immunotherapies in pediatric patients with trichotillomania. 61
32113788 2020
16
Concomitant trichotillomania, trichotemnomania and skin picking disorder in a woman. 61
32108615 2020
17
Pharmacological and behavioral treatment for trichotillomania: An updated systematic review with meta-analysis. 61
32390221 2020
18
Skin picking treatment with the Rothbaum cognitive behavioral therapy protocol: a randomized clinical trial. 61
32401873 2020
19
Trichotillomania-psychopathological correlates and associations with health-related quality of life in a large sample. 61
32264982 2020
20
Dupilumab therapy rapidly improved alopecia areata associated with trichotillomania in an atopic dermatitis patient. 61
32234288 2020
21
Paediatric gastric trichobezoar: the Rapunzel syndrome A report of two cases. 61
32161183 2020
22
Transdiagnostic dimensions in obsessive-compulsive and related disorders: associations with internalizing and externalizing symptoms. 61
32138800 2020
23
[Psychiatric and psychological support for an adolescent woman with chromosome 22 deletion syndrome and intellectual disability: a good outcome]. 61
32202548 2020
24
Successful treatment of trichotillomania with repetitive transcranial magnetic stimulation: A report of two cases with review of literature. 61
32135483 2020
25
Duration of illness and cortical thickness in trichotillomania: Preliminary evidence for illness change over time. 61
31954616 2020
26
An atypical case of early-onset trichotillomania - Management implications. 61
31954332 2020
27
Trichotillomania: Case report of pharmacological treatment outcome with clomipramine. 61
31740214 2020
28
Insights into recurrent body-focused repetitive behaviors: evidenced by New York Times commenters. 61
32078025 2020
29
[New-onset trichotillomania during treatment with stimulant drugs. About two pediatric clinical cases]. 61
31984712 2020
30
Trichoscopic evaluation of frontal hairline recession in Egyptian female patients. 61
32048427 2020
31
Trichotillomania associated with a 25-hydroxy vitamin D deficiency: A case report. 61
31942278 2020
32
Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder. 61
31576938 2020
33
An Unusual Case of Hypoproteinemia in Childhood: Keep in Mind Trichobezoar. 61
32195212 2020
34
A Modified Laparoscopic Technique for the Removal of Nonfragmentable Giant Gastric Trichobezoar. 61
32165844 2020
35
Trichopsychodermatology: The Psychiatric and Psychosocial Aspects of Hair Disorders. 61
31714654 2020
36
Management of a trichobezoar caused by consumption of artificial hair extensions. 61
31988057 2020
37
Trichoscopic Features of Eyebrow Trichotillomania: It Looks Similar to Scalp Trichotillomania. 61
32363102 2020
38
Hair pulling antecedents in trichotillomania: Their relationship with experiential avoidance. 61
31939684 2020
39
Acceptance and Commitment Therapy for Trichotillomania: A Randomized Controlled Trial of Adults and Adolescents. 61
30117327 2020
40
Measuring Treatment Response in Pediatric Trichotillomania: A Meta-Analysis of Clinical Trials. 61
31794677 2019
41
Rare case of trichobezoar causing pancreatitis in a young woman. 61
31801773 2019
42
Comorbidity in trichotillomania (hair-pulling disorder): A cluster analytical approach. 61
31692297 2019
43
Treatment of trichotillomania and subthreshold bipolar disorder with lithium. 61
31605657 2019
44
Pediatric trichotillomania: Review of management. 61
31588617 2019
45
Family functioning in pediatric trichotillomania, obsessive compulsive disorder, and healthy comparison youth. 61
31586836 2019
46
Giant gastroduodenal trichobezoar: A case report. 61
31750349 2019
47
The Beliefs in Trichotillomania Scale (BiTS): Factor analyses and preliminary validation. 61
30968971 2019
48
Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder. 61
31518848 2019
49
Linear Alopecic Patches in a Child: An Unusual Presentation of Trichotillomania. 61
31544085 2019
50
N-Acetylcysteine in psychodermatological disorders. 61
31444827 2019

Variations for Trichotillomania

ClinVar genetic disease variations for Trichotillomania:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 SLITRK1 NM_052910.2(SLITRK1):c.1264del (p.Leu422fs)deletion Pathogenic 1578 rs193302861 13:84454379-84454379 13:83880244-83880244

Expression for Trichotillomania

Search GEO for disease gene expression data for Trichotillomania.

Pathways for Trichotillomania

GO Terms for Trichotillomania

Cellular components related to Trichotillomania according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 SLITRK5 SLITRK3 SLITRK2 SLITRK1 SLC1A1 SIGLEC5
2 synapse GO:0045202 9.7 SLITRK5 SLITRK1 SLC1A1 DRD3 DRD2 DLGAP3
3 integral component of postsynaptic membrane GO:0099055 9.54 SLITRK3 SLITRK2 DRD2
4 integral component of postsynaptic density membrane GO:0099061 9.5 SLITRK3 SLITRK1 DRD3
5 glutamatergic synapse GO:0098978 9.43 SLITRK2 SLITRK1 DRD4 DRD3 DRD2 DLGAP3
6 dopaminergic synapse GO:0098691 9.4 DRD3 DRD2
7 GABA-ergic synapse GO:0098982 9.02 SLITRK3 SLITRK2 SLITRK1 DRD3 DRD2

Biological processes related to Trichotillomania according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.92 SLITRK5 SLC1A1 DRD4 DLGAP1
2 response to amphetamine GO:0001975 9.74 DRD4 DRD3 DRD2
3 adult behavior GO:0030534 9.73 SLITRK5 SLITRK1 DRD2
4 regulation of presynapse assembly GO:1905606 9.72 SLITRK3 SLITRK2 SLITRK1
5 synaptic membrane adhesion GO:0099560 9.71 SLITRK3 SLITRK2 SLITRK1
6 negative regulation of protein secretion GO:0050709 9.7 DRD4 DRD3 DRD2
7 arachidonic acid secretion GO:0050482 9.69 DRD4 DRD3 DRD2
8 negative regulation of adenylate cyclase activity GO:0007194 9.67 DRD3 DRD2
9 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.67 DRD3 DRD2
10 dopamine receptor signaling pathway GO:0007212 9.67 DRD4 DRD3 DRD2
11 negative regulation of cytosolic calcium ion concentration GO:0051481 9.66 DRD3 DRD2
12 prepulse inhibition GO:0060134 9.66 DRD3 DRD2
13 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.65 DRD3 DRD2
14 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.65 DRD3 DRD2
15 positive regulation of renal sodium excretion GO:0035815 9.65 DRD3 DRD2
16 behavioral response to cocaine GO:0048148 9.65 DRD4 DRD3 DRD2
17 G protein-coupled receptor internalization GO:0002031 9.64 DRD3 DRD2
18 striatum development GO:0021756 9.64 SLITRK5 DRD2
19 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.63 DRD4 DRD3
20 regulation of potassium ion transport GO:0043266 9.63 DRD3 DRD2
21 synaptic transmission, dopaminergic GO:0001963 9.63 DRD4 DRD3 DRD2
22 signaling GO:0023052 9.62 DLGAP3 DLGAP1
23 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.61 DRD3 DRD2
24 regulation of neurotransmitter uptake GO:0051580 9.61 DRD3 DRD2
25 negative regulation of voltage-gated calcium channel activity GO:1901386 9.61 DRD4 DRD3 DRD2
26 negative regulation of dopamine receptor signaling pathway GO:0060160 9.6 DRD3 DRD2
27 regulation of locomotion involved in locomotory behavior GO:0090325 9.59 DRD3 DRD2
28 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.58 DRD4 DRD2
29 acid secretion GO:0046717 9.58 DRD3 DRD2
30 behavioral response to ethanol GO:0048149 9.58 DRD4 DRD3 DRD2
31 positive regulation of synapse assembly GO:0051965 9.56 SLITRK5 SLITRK3 SLITRK2 SLITRK1
32 dopamine metabolic process GO:0042417 9.54 DRD4 DRD3 DRD2
33 grooming behavior GO:0007625 9.5 SLITRK5 HOXB8 DRD2
34 axonogenesis GO:0007409 9.35 SLITRK5 SLITRK3 SLITRK2 SLITRK1 DRD2
35 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.33 DRD4 DRD3 DRD2
36 response to histamine GO:0034776 8.8 DRD4 DRD3 DRD2

Molecular functions related to Trichotillomania according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.43 DRD4 DRD3 DRD2
2 dopamine binding GO:0035240 9.33 DRD4 DRD3 DRD2
3 adrenergic receptor activity GO:0004935 9.32 DRD3 DRD2
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.13 DRD4 DRD3 DRD2
5 dopamine neurotransmitter receptor activity GO:0004952 8.8 DRD4 DRD3 DRD2

Sources for Trichotillomania

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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