MCID: TRC010
MIFTS: 46

Trichotillomania

Categories: Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Trichotillomania

MalaCards integrated aliases for Trichotillomania:

Name: Trichotillomania 57 12 76 53 75 37 13 44 15 40 73
Hair-Pulling 29 6
Ttm 57 75
Hair-Pulling Syndrome 53

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant
multifactorial

Miscellaneous:
affected individuals can pull hair from any part of the body, including eyelashes and eyebrows
overlap with obsessive-compulsive disorder (ocd, )
overlap with tourette syndrome
affects 1 to 3% of the population
one patient reported with slitrk1 mutation (as of january 2010)


HPO:

32

Classifications:



External Ids:

OMIM 57 613229
Disease Ontology 12 DOID:0050587
MeSH 44 D014256
KEGG 37 H00864
ICD10 33 F63.3
UMLS 73 C0040953

Summaries for Trichotillomania

NIH Rare Diseases : 53 Trichotillomania is a disorder characterized by an overwhelming urge to repeatedly pull out one's own hair, resulting in hair loss (alopecia).  It is classified under the obsessive-compulsive and related disorders category. Trichotillomania results in highly variable patterns of hair loss. The scalp is the most common area of hair pulling, followed by the eyebrows, eyelashes, pubic and perirectal areas, axillae, limbs, torso, and face. The resulting alopecia can range from thin unnoticeable areas of hair loss to total baldness. Some people chew or swallow the hair they pull out (trichophagy), which can result in gastrointestinal problems or develop a trichobezoar (hairball in the intestines or stomach). In many cases, people with this disorder feel extreme tension when they feel an impulse, followed by relief, gratification or pleasure afterwards. The disorder may be mild and manageable, or severe and debilitating.  The cause is unknown, though both environmental and genetic causes have been suspected. Treatment may involve cognitive behavior therapy, such as habit reversal training (learning to substitute the hair-pulling behavior) and/or drug therapy, but these are not always effective.

MalaCards based summary : Trichotillomania, also known as hair-pulling, is related to impulse control disorder and obsessive-compulsive disorder. An important gene associated with Trichotillomania is SLITRK1 (SLIT And NTRK Like Family Member 1). The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotypes are obsessive-compulsive behavior and alopecia

Disease Ontology : 12 An impulse control disorder that involves the uncontrollable plucking of ones hair.

OMIM : 57 Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Tourette syndrome (GTS; 137580) or obsessive-compulsive disorder (OCD; 164230) (review by Novak et al., 2009). (613229)

UniProtKB/Swiss-Prot : 75 Trichotillomania: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder.

Wikipedia : 76 Trichotillomania (TTM), also known as hair pulling disorder, is an impulse control disorder... more...

Related Diseases for Trichotillomania

Graphical network of the top 20 diseases related to Trichotillomania:



Diseases related to Trichotillomania

Symptoms & Phenotypes for Trichotillomania

Symptoms via clinical synopsis from OMIM:

57
Skin Nails Hair Hair:
alopecia resulting from compulsive hair pulling

Neurologic Behavioral Psychiatric Manifestations:
hair pulling, chronic, compulsive, repetitive
distress and functional impairment resulting from hair pulling behavior


Clinical features from OMIM:

613229

Human phenotypes related to Trichotillomania:

32
# Description HPO Frequency HPO Source Accession
1 obsessive-compulsive behavior 32 HP:0000722
2 alopecia 32 HP:0001596
3 hair-pulling 32 HP:0012167

MGI Mouse Phenotypes related to Trichotillomania:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.92 ABCB6 DLGAP3 PRL SLITRK5

Drugs & Therapeutics for Trichotillomania

Drugs for Trichotillomania (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
4
Sertraline Approved Phase 4 79617-96-2 68617
5 Central Nervous System Stimulants Phase 4
6 Dopamine Agents Phase 4,Phase 3
7 Dopamine Uptake Inhibitors Phase 4
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
9 Neurotransmitter Uptake Inhibitors Phase 4
10 Antiemetics Phase 4
11 Antipsychotic Agents Phase 4,Not Applicable
12 Autonomic Agents Phase 4
13 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
14 Gastrointestinal Agents Phase 4
15 Peripheral Nervous System Agents Phase 4,Phase 2
16 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
17 Serotonin Agents Phase 4
18 Serotonin Uptake Inhibitors Phase 4
19 Tranquilizing Agents Phase 4,Not Applicable
20 Antidepressive Agents Phase 4,Phase 2
21
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
22
Carbidopa Approved Phase 3 28860-95-9 34359 38101
23
Levodopa Approved Phase 3 59-92-7 6047
24 Adjuvants, Immunologic Phase 3
25 Antiparkinson Agents Phase 3
26 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
27 Carbidopa, levodopa drug combination Phase 3
28 Dopamine agonists Phase 3
29
Acetylcysteine Approved, Investigational Phase 2,Not Applicable 616-91-1 12035
30
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
31
Dronabinol Approved, Illicit Phase 2 1972-08-3 16078
32
Ketamine Approved, Vet_approved Phase 2 6740-88-1 3821
33
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
35
Glutamic Acid Approved, Nutraceutical Phase 2 56-86-0 33032
36 Vitamin B Complex Phase 2
37 Micronutrients Phase 2
38 Trace Elements Phase 2
39 Vitamins Phase 2
40 Antidotes Phase 2,Not Applicable
41 Anti-Infective Agents Phase 2,Not Applicable
42 Antioxidants Phase 2,Not Applicable
43 Antiviral Agents Phase 2,Not Applicable
44 Expectorants Phase 2,Not Applicable
45 N-monoacetylcystine Phase 2,Not Applicable
46 Protective Agents Phase 2,Not Applicable
47 Respiratory System Agents Phase 2,Not Applicable
48 Narcotic Antagonists Phase 2
49 Narcotics Phase 2
50 Analgesics Phase 2

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Methylphenidate in ADHD With Trichotillomania Unknown status NCT00552266 Phase 4 Methylphenidate
2 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4 Olanzapine
3 Sertraline and Habit Reversal in the Treatment of Patients With Trichotillomania Completed NCT00118014 Phase 4 Sertraline
4 Safety/Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Parkinson's Subjects Completed NCT00360568 Phase 3 Levodopa-carbidopa intestinal gel
5 Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease Completed NCT00335153 Phase 3 Levodopa-carbidopa intestinal gel
6 Dronabinol in Trichotillomania Not yet recruiting NCT03530800 Phase 2, Phase 3 Dronabinol;Placebo
7 Testing a New Therapy for Trichotillomania Unknown status NCT00872742 Phase 2
8 Awareness Enhancement and Monitoring Device for Treatment of Trichotillomania Completed NCT01654523 Phase 2
9 Inositol in Trichotillomania Completed NCT01875445 Phase 2 Inositol;Placebo
10 Trichotillomania: Group Cognitive-Behavioral Therapy Completed NCT01968343 Phase 2
11 N-Acetylcysteine for Pediatric Trichotillomania Completed NCT00993265 Phase 2 N-Acetylcysteine;Placebo
12 Naltrexone in the Treatment of Trichotillomania Completed NCT00775229 Phase 2 Naltrexone;Placebo
13 Stepped Care in the Treatment of Trichotillomania Completed NCT01118637 Phase 2
14 N-Acetyl Cysteine in Trichotillomania Completed NCT00354770 Phase 2 Placebo;N-Acetyl Cysteine
15 Cognitive Behavioral Therapy for Trichotillomania Completed NCT00740909 Phase 1, Phase 2
16 Marinol in Trichotillomania or Obsessive Compulsive Disorder Completed NCT01093976 Phase 2 Dronabinol
17 N-acetylcysteine (NAC) for Children With Tourette Syndrome Completed NCT01172288 Phase 2 N-Acetylcysteine (NAC);Placebo
18 Ketamine Infusion for Obsessive-Compulsive Disorder Completed NCT01349231 Phase 2 ketamine
19 Milk Thistle in Trichotillomania in Children and Adults Recruiting NCT02473913 Phase 2 Milk Thistle;Placebo
20 Valchlor in the Treatment of Lichen Planopilaris Recruiting NCT03417141 Phase 2 Valchlor
21 N-acetylcysteine (NAC) for Pediatric Obsessive-Compulsive Disorder Active, not recruiting NCT01172275 Phase 2 N-Acetylcysteine;Placebo
22 Efficacy of Topical Gentamycin for Hereditary Hypotrichosis Simplex Caused by Nonsense Mutations in CDSN Not yet recruiting NCT03492866 Phase 2 Gentamicin Sulfate
23 Hair Fall in Patients on Low Dose Methotrexate Unknown status NCT02591823
24 Online Response Inhibition Training for Trichotillomania Completed NCT01984333 Not Applicable
25 Habit Reversal Training for Children and Adolescents With Trichotillomania Completed NCT01445444 Not Applicable
26 Trial of Aripiprazole in Trichotillomania Completed NCT00947154 Not Applicable aripiprazole
27 Efficacy of COMB (Comprehensive Behavioral) Model of Treatment of Trichotillomania Completed NCT01878110 Not Applicable
28 Online Treatment of Trichotillomania Completed NCT02044237 Not Applicable
29 Response Inhibition Training for Individuals With Trichotillomania Completed NCT01638975 Not Applicable
30 Developing Effective Response Inhibition Training for Symptom Relief in OCD and Trichotillomania Completed NCT02059980 Not Applicable
31 Examining Behavior Therapy for Trichotillomania in Children and Adolescents Completed NCT00917098 Not Applicable
32 Cognitive Behavioral Treatment of Pediatric Trichotillomania Completed NCT00043563 Not Applicable
33 Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions Completed NCT00004550
34 Glutathione Levels and Compulsivity Completed NCT02794389 Not Applicable N-acetyl cysteine;Placebo
35 Cortical Excitability in Obsessive-Compulsive and Related Disorders Completed NCT00029068
36 Evaluation of a Brief Surf the Urge Intervention Completed NCT02771886 Not Applicable
37 Genetics of Obsessive-Compulsive Disorder Completed NCT00001548
38 Comprehensive Behavioral (ComB) Model of Treatment for Trichotillomania Recruiting NCT03486041 Not Applicable
39 Cognitive Training in Patients With Trichotillomania (Hair-pulling Disorder) Recruiting NCT02794753 Not Applicable
40 Motor Control Mechanisms by CNS of Tuina in Patients With Lumbar Disk Herniation Recruiting NCT03475095 Not Applicable
41 Alcohol Related Impairment and Reinforcement: Pre to Post Roux en Y Gastric Bypass Surgery Recruiting NCT02370732 Not Applicable
42 Cognitive Behavioral Group Therapy for Trichotillomania (Hair Pulling Disorder) Active, not recruiting NCT02747771
43 Treating Skin Picking With Cognitive-Behavioral Protocol in Individual and Group Format. Active, not recruiting NCT03182478 Not Applicable
44 Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals Active, not recruiting NCT01075672 Not Applicable
45 Relevance of Trichoscopy in Differential Diagnosis of Focal Non-cicatricial Alopecia in Children Not yet recruiting NCT03260777

Search NIH Clinical Center for Trichotillomania

Cochrane evidence based reviews: trichotillomania

Genetic Tests for Trichotillomania

Genetic tests related to Trichotillomania:

# Genetic test Affiliating Genes
1 Hair-Pulling 29 SLITRK1

Anatomical Context for Trichotillomania

MalaCards organs/tissues related to Trichotillomania:

41
Skin, Eye, Testes, Brain

Publications for Trichotillomania

Articles related to Trichotillomania:

(show top 50) (show all 577)
# Title Authors Year
1
Trichotillomania Ranging from "Ritual to Illness" and as a Rare Clinical Manifestation of Frontotemporal Dementia: Review of Literature and Case Report. ( 29769783 )
2018
2
Striatal abnormalities in trichotillomania: a multi-site MRI analysis. ( 29515968 )
2018
3
Computerized response inhibition training for children with trichotillomania. ( 29407564 )
2018
4
Clinical Characteristics and Comorbidity of Pediatric Trichotillomania: the Study of 38 Cases in Croatia. ( 29546862 )
2018
5
Remote treatment of sleep-related trichotillomania and trichophagia. ( 29468679 )
2018
6
Atomoxetine in the Treatment of Adolescent With Trichotillomania and Attention-Deficit/Hyperactivity Disorder. ( 29533364 )
2018
7
Trichotillomania ( 29630238 )
2018
8
Awareness Enhancing and Monitoring Device plus Habit Reversal in the Treatment of Trichotillomania: An Open Feasibility Trial. ( 29607291 )
2018
9
Salivary sex hormones in adolescent females with trichotillomania. ( 29753253 )
2018
10
Types of avoidance in hair-pulling disorder (trichotillomania): An exploratory and confirmatory analysis. ( 29306818 )
2018
11
Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania. ( 29682419 )
2018
12
The Dermoscopic "Pluck Out Sign" for Beard Trichotillomania. ( 29457007 )
2018
13
Trichotillomania Associated With Aripiprazole: A Case Report. ( 29257789 )
2018
14
Salivary Inflammatory Markers in Trichotillomania: A Pilot Study. ( 29920483 )
2018
15
Trichotillomania: the impact of treatment history on the outcome of an Internet-based intervention. ( 28461751 )
2017
16
Trichotillomania and Bipolar Disorder. ( 28142271 )
2017
17
Trichoscopic clues for diagnosis of alopecia areata and trichotillomania in Asians. ( 28074524 )
2017
18
A double-blind, placebo-controlled study of inositol in trichotillomania. ( 27824633 )
2017
19
Trichotillomania in celiac disease patient refractory to iron replacement. ( 28779566 )
2017
20
Making sense of the role of sense organs in trichotillomania. ( 28827858 )
2017
21
"i hair": A prognostic marker in alopecia areata & trichotillomania. ( 29263543 )
2017
22
Systematic Review of Published Primary Studies of Neuropsychology and Neuroimaging in Trichotillomania. ( 28835311 )
2017
23
Cortical thickness abnormalities in trichotillomania: international multi-site analysis. ( 28664230 )
2017
24
Increased Trichotillomania Symptoms in a Child With Fluoxetine Treatment. ( 28118168 )
2017
25
Pathological grooming: Evidence for a single factor behind trichotillomania, skin picking and nail biting. ( 28902896 )
2017
26
Pharmacotherapy of trichotillomania. ( 28440210 )
2017
27
Trichotillomania: a case report with clinical and dermatoscopic differential diagnosis with alopecia areata. ( 28225970 )
2017
28
Modified-Release Methylphenidate-Related Trichotillomania in a Boy with Autism Spectrum Disorder. ( 28394174 )
2017
29
Refining Treatment Approaches in Comorbid Trichotillomania and Bipolar Disorder: Response to Sharma and Baczynski. ( 28142278 )
2017
30
A Preliminary Investigation of Metacognitive Therapy and Habit Reversal as a Treatment for Trichotillomania. ( 28903787 )
2017
31
Trichotillomania and its clinical relationship to depression and anxiety. ( 28429625 )
2017
32
Clarifying the Relationship between Trichotillomania and Anxiety. ( 28989859 )
2017
33
Burnt Matchstick Sign - A new Trichoscopic finding in Trichotillomania. ( 28761268 )
2017
34
Videodermoscopy supports the diagnosis of eyelash trichotillomania. ( 28426900 )
2017
35
Trichotillomania in Attention-Deficit/Hyperactivity Disorder Under Methylphenidate Treatment. ( 28492426 )
2017
36
Trichotillomania: a good response to treatment with N-acetylcysteine. ( 28954106 )
2017
37
Preventing, treating, and predicting barbering: A fundamental role for biomarkers of oxidative stress in a mouse model of Trichotillomania. ( 28426681 )
2017
38
Atomoxetine-Related Trichotillomania in a Boy with Attention-Deficit/Hyperactivity Disorder. ( 29099621 )
2017
39
Self-inflicted skin lesions and trichotillomania due to rolled hair. ( 28621120 )
2017
40
"The girl who pulled her hair"-Positive-affect trichotillomania in a 2-year old child. ( 28784383 )
2017
41
Predictors of comorbid eating disorders and association with other obsessive-compulsive spectrum disorders in trichotillomania. ( 28667830 )
2017
42
Exposure and Ritual Prevention Therapy for Trichotillomania: Two Case Reports. ( 29099553 )
2017
43
Trichotillomania and co-occurring anxiety. ( 27668531 )
2017
44
Sensory over-responsivity in trichotillomania (hair-pulling disorder). ( 29202385 )
2017
45
Placebo response in trichotillomania. ( 28628502 )
2017
46
Trichotillomania and trichophagia - diagnosis, treatment, prevention. The attempt to establish guidelines of treatment in Poland. ( 27086333 )
2016
47
Affective correlates of trichotillomania across the pulling cycle: Findings from an Italian sample of self-identified hair pullers. ( 27836242 )
2016
48
Trichobezoar (Rapunzel syndrome) in an adolescent patient with Trichotillomania and Generalized Anxiety Disorder: A case report. ( 27969077 )
2016
49
Review of available studies of the neurobiology and pharmacotherapeutic management of trichotillomania. ( 26966559 )
2016
50
Comprehensive Behavioral Treatment of Trichotillomania: A Treatment Development Study. ( 26643276 )
2016

Variations for Trichotillomania

ClinVar genetic disease variations for Trichotillomania:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SLITRK1 NM_052910.2(SLITRK1): c.1264delC (p.Leu422Phefs) deletion Pathogenic rs193302861 GRCh37 Chromosome 13, 84454379: 84454379
2 SLITRK1 NM_052910.2(SLITRK1): c.1264delC (p.Leu422Phefs) deletion Pathogenic rs193302861 GRCh38 Chromosome 13, 83880244: 83880244

Expression for Trichotillomania

Search GEO for disease gene expression data for Trichotillomania.

Pathways for Trichotillomania

GO Terms for Trichotillomania

Biological processes related to Trichotillomania according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axonogenesis GO:0007409 9.26 SLITRK1 SLITRK5
2 positive regulation of synapse assembly GO:0051965 9.16 SLITRK1 SLITRK5
3 skin development GO:0043588 8.96 ABCB6 SLITRK5
4 adult behavior GO:0030534 8.62 SLITRK1 SLITRK5

Sources for Trichotillomania

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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