MCID: TRC012
MIFTS: 45

Trichuriasis

Categories: Blood diseases, Gastrointestinal diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Trichuriasis

MalaCards integrated aliases for Trichuriasis:

Name: Trichuriasis 12 52 3 43 15 17 32
Whipworm Infection 52 3
Infection by Trichuris Trichiura 71
Infection by Trichuris Trichura 12
Trichuris Trichiura Infection 12
Trichuriasis Infection 12
Trichocephaliasis 52
Whipworm Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1252
ICD9CM 34 127.3
MeSH 43 D014257
NCIt 49 C128399
SNOMED-CT 67 3752003 60570001
ICD10 32 B79
UMLS 71 C0040954

Summaries for Trichuriasis

CDC : 3 An estimated 604-795 million people in the world are infected with whipworm. Whipworm, hookworm, and Ascaris are known as soil-transmitted helminths (parasitic worms). Together, they account for a major burden of disease worldwide. Whipworms live in the large intestine and whipworm eggs are passed in the feces of infected persons. If the infected person defecates outside (near bushes, in a garden, or field) or if human feces as used as fertilizer, eggs are deposited on soil. They can then mature into a form that is infective. Whipworm infection is caused by ingesting eggs. This can happen when hands or fingers that have contaminated dirt on them are put in the mouth or by consuming vegetables or fruits that have not been carefully cooked, washed or peeled. People infected with whipworm can suffer light or heavy infections. People with light infections usually have no symptoms. People with heavy symptoms can experience frequent, painful passage of stool that contains a mixture of mucus, water, and blood. Rectal prolapse can also occur. Children with heavy infections can become severely anemic and growth-retarded. Whipworm infections are treatable with medication prescribed by your health care provider.

MalaCards based summary : Trichuriasis, also known as whipworm infection, is related to cytokine deficiency and trichinosis, and has symptoms including abdominal pain, diarrhea and rectal prolapse. An important gene associated with Trichuriasis is IL13 (Interleukin 13), and among its related pathways/superpathways are PAK Pathway and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs Mebendazole and Piperazine have been mentioned in the context of this disorder. Affiliated tissues include intestine in humans, testes and colon.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection located in intestine in humans, has material basis in Trichuris trichiura, which is transmitted by ingestion of food contaminated with egg-carrying soil. The infection has symptom abdominal pain, has symptom diarrhea, has symptom rectal prolapse and has symptom growth retardation.

Wikipedia : 74 Trichuriasis, also known as whipworm infection, is an infection by the parasitic worm Trichuris... more...

Related Diseases for Trichuriasis

Diseases related to Trichuriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 cytokine deficiency 31.2 IL9 IL13
2 trichinosis 30.6 IL9 IL13 IL10
3 ulcerative colitis 30.3 TNF IL13 IL10 CCR6
4 schistosomiasis 30.3 TNF IL9 IL13 IL10
5 onchocerciasis 30.2 STH SERPINA3 IL13
6 enterobiasis 30.1 STH EPGN
7 colitis 30.1 TNF IL13 IL10 CCR6
8 ascaris lumbricoides infection 30.1 STH SERPINA3 IL13 EPGN
9 celiac disease 1 29.9 TNF IL13 IL10 CCR6
10 strongyloidiasis 29.8 STH IL13 EPGN
11 opisthorchiasis 29.5 TNF SERPINA3 EPGN
12 dysentery 29.5 TNF STH IL10 CCR6
13 parasitic helminthiasis infectious disease 27.9 TNF STH SERPINA3 IL9 IL13 IL10
14 ascaridiasis 10.8
15 punctate inner choroidopathy 10.5 TNF IL10
16 tropical endomyocardial fibrosis 10.5 TNF IL10
17 endomyocardial fibrosis 10.5 TNF IL10
18 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL13
19 multifocal choroiditis 10.5 TNF IL10
20 spotted fever rickettsiosis 10.5 TNF IL10
21 palladium allergic contact dermatitis 10.5 TNF IL10
22 actinic prurigo 10.4 TNF IL13
23 ancylostomiasis 10.4
24 loiasis 10.4 IL13 IL10
25 inflammatory bowel disease 10.4
26 post-transplant lymphoproliferative disease 10.4 TNF IL10
27 orofacial granulomatosis 10.4 TNF IL10
28 transient hypogammaglobulinemia 10.4 TNF IL10
29 transverse myelitis 10.4 TNF IL10
30 eales disease 10.4 TNF IL10
31 chemical colitis 10.4 TNF IL10
32 conjunctivitis 10.4 TNF IL13 IL10
33 combined thymoma 10.3 TNF IL13 IL10
34 african tick-bite fever 10.3 TNF IL13 IL10
35 mycoplasma pneumoniae pneumonia 10.3 TNF IL13 IL10
36 uveitis 10.3 TNF IL9 IL10
37 allergic conjunctivitis 10.3 TNF IL13 IL10
38 deficiency anemia 10.3
39 necatoriasis 10.3
40 bronchiolitis obliterans 10.3 TNF IL13 IL10
41 bronchiolitis 10.3 TNF IL13 IL10
42 dengue hemorrhagic fever 10.3 TNF IL13 IL10
43 cutaneous leishmaniasis 10.3 TNF IL13 IL10
44 esophagitis 10.3 TNF IL13 IL10
45 visceral leishmaniasis 10.3 TNF IL13 IL10
46 proteasome-associated autoinflammatory syndrome 1 10.3 TNF IL13 IL10
47 pulmonary edema 10.3 TNF IL13 IL10
48 food allergy 10.3 TNF IL13 IL10
49 ige responsiveness, atopic 10.3
50 intussusception 10.3

Graphical network of the top 20 diseases related to Trichuriasis:



Diseases related to Trichuriasis

Symptoms & Phenotypes for Trichuriasis

Symptoms:

12
  • abdominal pain
  • diarrhea
  • rectal prolapse
  • growth retardation

Drugs & Therapeutics for Trichuriasis

Drugs for Trichuriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mebendazole Approved, Vet_approved Phase 4 31431-39-7 4030
2
Piperazine Approved, Vet_approved Phase 4 110-85-0 4837
3
Sodium citrate Approved, Investigational Phase 4 68-04-2
4
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
5
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
6 Oxantel Experimental Phase 4 36531-26-7
7 Neuromuscular Agents Phase 4
8 Citrate Phase 4
9 Pyrantel Pamoate Phase 4
10 Neuromuscular Blocking Agents Phase 4
11 Piperazine citrate Phase 4
12 DMP 777 Phase 4 157341-41-8
13 Immunologic Factors Phase 4
14 Adjuvants, Immunologic Phase 4
15 Antirheumatic Agents Phase 4
16
Albendazole Approved, Vet_approved Phase 2 54965-21-8 2082
17
Ivermectin Approved, Investigational, Vet_approved Phase 2 70288-86-7 6474909
18 Milbemycin Phase 2
19 Anti-Infective Agents Phase 2
20 Antimitotic Agents Phase 2
21 Anthelmintics Phase 2
22 Antiparasitic Agents Phase 2
23 Antiprotozoal Agents Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 The Efficacy of 5 Anthelmintic Regimes Against T. Trichiura Infections in Schoolchildren in Jimma, Ethiopia Completed NCT01327469 Phase 4 Albendazole, 2 x 400mg;Albendazole 400mg;Mebendazole 500mg;Mebendazole 2 x 500mg;Pyrantel-oxantel + mebendazole
2 Longitudinal Study of Efficacy of Standard Albendazole Treatment Versus Levamisole/Pyrantel Pamoate on Soil Transmitted Helminth Infections Completed NCT00659997 Phase 4 Albendazole;Levamisole
3 Efficacy and Safety of Ivermectin and Albendazole Co-administration in School-aged Children and Adults Infected With Trichuris Trichiura: a Multi-country Randomized Controlled Trial Recruiting NCT03527732 Phase 2, Phase 3 Albendazole;Albendazole and Ivermectin
4 Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris Trichiura in Adolescents: a Randomized Controlled Trial Completed NCT03501251 Phase 2 Moxidectin 8mg;Moxidectin 8 mg + albendazole 400 mg;Moxidectin 16 mg;Moxidectin 16 mg + albendazole 400 mg;Moxidectin 24 mg;Moxidectin 24 mg + albendazole 400 mg
5 Efficacy and Safety of Ascending Dosages of Albendazole Against T. Trichiura and Hookworm in Preschool- and School-aged Children and Adults: a Randomized Controlled Trial Active, not recruiting NCT03527745 Phase 2 Albendazole;Albendazole;Albendazole;Albendazole;Placebo
6 An Assessor Blind, Randomized, Comparative Study of the Efficacy of Different Doses of Oxfendazole Compared to Single Dose Albendazole in the Treatment of Trichuris Trichiura Infection in Adults Not yet recruiting NCT03435718 Phase 2 Oxfendazole;Albendazole
7 Prospective, Parallel-group, Open-label Randomized Controlled Trial of Four Treatment Regimes for Trichuriasis in Pediatric Patients Not yet recruiting NCT04041453 Phase 2 Ivermectin;Albendazole
8 An Open Comparative Study of the Efficacy of Different Doses of Oxfendazole Compared to Single Dose Albendazole in the Treatment of Trichuris Trichiura Infection in Adults Withdrawn NCT02636803 Phase 2 oxfendazole;albendazole
9 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
10 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
11 Study of Patients With Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Trichuriasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole
Ivermectin
Mebendazole
Pyrantel
Pyrantel Pamoate

Cochrane evidence based reviews: trichuriasis

Genetic Tests for Trichuriasis

Anatomical Context for Trichuriasis

The Foundational Model of Anatomy Ontology organs/tissues related to Trichuriasis:

19
Intestine In Humans

MalaCards organs/tissues related to Trichuriasis:

40
Testes, Colon, Skin, T Cells, Small Intestine, B Cells

Publications for Trichuriasis

Articles related to Trichuriasis:

(show top 50) (show all 463)
# Title Authors PMID Year
1
Whipworm infection promotes bacterial invasion, intestine microbiota imbalance and cellular immunomodulation. 61
31843966 2019
2
Blood pressure risk factors in early adolescents: results from a Ugandan birth cohort. 61
30804461 2019
3
BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring - recent advances and future perspectives. 61
31490179 2019
4
Parasitic infections in Malaysian aborigines with pulmonary tuberculosis: a comparative cross-sectional study. 61
31363922 2019
5
Antihelminthic Efficacy Against Trichuriasis. 61
31211830 2019
6
Biological role of excretory-secretory proteins in endemic parasites of Latin America and the Caribbean. 61
31092301 2019
7
Efficacy of Albendazole and Mebendazole With or Without Levamisole for Ascariasis and Trichuriasis. 61
31110573 2019
8
Efficacy and safety of ivermectin and albendazole co-administration in school-aged children and adults infected with Trichuris trichiura: study protocol for a multi-country randomized controlled double-blind trial. 61
30885157 2019
9
Molecular characterization of Trichuris species isolated from humans, dogs and cats in a rural community in Peninsular Malaysia. 61
30500371 2019
10
Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease. 61
30614200 2019
11
Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection. 61
30640950 2019
12
Pseudohypoadrenocorticism in a Siberian Husky with Trichuris vulpis Infection. 61
31263625 2019
13
Severe whipworm (Trichuris spp.) infection in the hamadryas baboon (Papio hamadryas). 61
30464076 2019
14
Diagnosis of feline whipworm infection using a coproantigen ELISA and the prevalence in feral cats in southern Florida. 61
31014727 2018
15
Deworming in non-pregnant adolescent girls and adult women: a systematic review and meta-analysis. 61
30572948 2018
16
Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community. 61
30040946 2018
17
Association of intestinal pathogens with faecal markers of environmental enteric dysfunction among slum-dwelling children in the first 2 years of life in Bangladesh. 61
30133067 2018
18
Worm Infestation: Diagnosis, Treatment and Prevention. 61
29127616 2018
19
Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial. 61
29617737 2018
20
Genetic characterisation and phylogenetic status of whipworms (Trichuris spp.) from captive non-human primates in China, determined by nuclear and mitochondrial sequencing. 61
30236150 2018
21
2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm. 61
29995893 2018
22
Infections of Soil-Transmitted Helminth in Refugees from North Korea. 61
29996634 2018
23
The burden of Neglected Tropical Diseases in Brazil, 1990-2016: A subnational analysis from the Global Burden of Disease Study 2016. 61
29864133 2018
24
[Investigation on intestinal nematode infections and their risk factors in Shanpo Sub-district, Jiangxia District, Wuhan City]. 61
30567034 2018
25
Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases. 61
29207309 2018
26
Trichuriasis. 61
29406051 2018
27
Prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa. 61
29378644 2018
28
Geographical distribution of soil transmitted helminths and the effects of community type in South Asia and South East Asia - A systematic review. 61
29346440 2018
29
Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review. 61
29382360 2018
30
Pathway of oxfendazole from the host into the worm: Trichuris suis in pigs. 61
29156431 2017
31
Clinical correlates of trichuriasis diagnosed at colonoscopy. 61
29058208 2017
32
Identifying Helminth Infections via Routine Fecal Parasitological Examinations in Korea. 61
28749758 2017
33
Occurrence of the most common helminth infections among children in the Eastern Slovak Republic. 61
28646696 2017
34
[Investigation of major parasitic diseases and related knowledge, attitude and practice among rural residents in Liyang City]. 61
29536713 2017
35
Soil-transmitted Helminth Infections in Schoolchildren of Laguna de Perlas (Nicaragua). 61
27616686 2017
36
Epidemiology of soil-transmitted helminthiases-related mortality in Brazil. 61
28103964 2017
37
Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo. 61
28182663 2017
38
Identification, Characterization, and Structure of Tm16 from Trichuris muris. 61
28884022 2017
39
Prevalence and intensity of soil transmitted helminths among school children of Mendera Elementary School, Jimma, Southwest Ethiopia. 61
28819509 2017
40
A First Case of Human Trichuriasis from a Roman Lead Coffin in France. 61
27853119 2016
41
Glucose Absorption by the Bacillary Band of Trichuris muris. 61
27588682 2016
42
Variability of whipworm infection and humoral immune response in a wild population of mole voles (Ellobius talpinus Pall.). 61
27079461 2016
43
Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms. 61
27572696 2016
44
Prevalence and risk factors of intestinal parasitism among two indigenous sub-ethnic groups in Peninsular Malaysia. 61
27430215 2016
45
Disregard of neurological impairments associated with neglected tropical diseases in Africa. 61
28239667 2016
46
Evaluation of iron deficiency anaemia for gastrointestinal causes in patients without GI symptoms in high prevalent GI malignancy zones. 61
27426957 2016
47
Immunoproliferative Small Intestinal Disease Associated with Overwhelming Polymicrobial Gastrointestinal Infection with Transformation to Diffuse Large B-cell Lymphoma. 61
26903604 2016
48
An unusual cause of overt gastrointestinal bleeding in a malnourished child. 61
26264463 2016
49
Productivity Loss Related to Neglected Tropical Diseases Eligible for Preventive Chemotherapy: A Systematic Literature Review. 61
26890487 2016
50
Compliance with anthelmintic treatment in the neglected tropical diseases control programmes: a systematic review. 61
26813098 2016

Variations for Trichuriasis

Expression for Trichuriasis

Search GEO for disease gene expression data for Trichuriasis.

Pathways for Trichuriasis

GO Terms for Trichuriasis

Cellular components related to Trichuriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TNF SERPINA3 IL9 IL13 IL10 EPGN
2 extracellular region GO:0005576 9.23 VNN2 TNF SERPINA3 IL9 IL13 IL10

Biological processes related to Trichuriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.43 TNF IL9 IL13 IL10 CCR6 CCL23
2 positive regulation of macrophage activation GO:0043032 9.4 IL13 IL10
3 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.37 TNF IL10
4 endothelial cell apoptotic process GO:0072577 9.32 TNF IL10
5 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 TNF IL10
6 receptor biosynthetic process GO:0032800 9.16 TNF IL10
7 inflammatory response GO:0006954 9.1 TNF SERPINA3 IL9 IL13 IL10 CCL23

Molecular functions related to Trichuriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF IL9 IL13 IL10 CCL23

Sources for Trichuriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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