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MCID: TRC012
MIFTS: 51

Trichuriasis

Categories: Gastrointestinal diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Trichuriasis

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MalaCards integrated aliases for Trichuriasis:

Name: Trichuriasis 12 54 45 15 17 3
Whipworm Infection 54 3
Infection by Trichuris Trichiura 74
Infection by Trichuris Trichura 12
Trichuris Trichiura Infection 12
Trichuriasis Infection 12
Trichocephaliasis 54
Whipworm Disease 12

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:1252
ICD9CM 36 127.3
MeSH 45 D014257
NCIt 51 C128399
SNOMED-CT 69 3752003 60570001
ICD10 34 B79
UMLS 74 C0040954
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Summaries for Trichuriasis

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Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection located in intestine in humans, has material basis in Trichuris trichiura, which is transmitted by ingestion of food contaminated with egg-carrying soil. The infection has symptom abdominal pain, has symptom diarrhea, has symptom rectal prolapse and has symptom growth retardation.

MalaCards based summary : Trichuriasis, also known as whipworm infection, is related to enterobiasis and tungiasis, and has symptoms including abdominal pain, diarrhea and rectal prolapse. An important gene associated with Trichuriasis is IL9 (Interleukin 9), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Pyrantel and Piperazine have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and t cells, and related phenotypes are hematopoietic system and immune system

CDC : 3 An estimated 604-795 million people in the world are infected with whipworm. Whipworm, hookworm, and Ascaris are known as soil-transmitted helminths (parasitic worms). Together, they account for a major burden of disease worldwide.

Wikipedia : 77 Trichuriasis, also known as whipworm infection, is an infection by the parasitic worm Trichuris... more...

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Related Diseases for Trichuriasis

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Diseases related to Trichuriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 enterobiasis 30.6 IL13 IL9
2 tungiasis 30.3 IL10 TNF
3 schistosomiasis 30.0 IL10 IL13 TNF
4 gastroenteritis 29.7 IL10 TNF
5 parasitic helminthiasis infectious disease 29.7 IL10 IL13 STH TNF
6 malaria 29.2 IDO1 IL10 IL13 IL9 TNF
7 cytokine deficiency 10.3 IL13 IL9
8 nickel allergic contact dermatitis 10.3 IL10 IL13
9 apple allergy 10.3 IL10 IL13
10 beta-lactam allergy 10.3 IL10 IL13
11 eosinophilic meningitis 10.3 IL10 IL13
12 radiculopathy 10.3 IL10 IL13
13 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 TNF
14 lipoid nephrosis 10.3 IL10 IL13
15 actinic prurigo 10.3 IL13 TNF
16 paranasal sinus disease 10.3 IL10 IL13
17 conjunctival disease 10.3 IL13 TNF
18 punctate inner choroidopathy 10.3 IL10 TNF
19 tropical endomyocardial fibrosis 10.3 IL10 TNF
20 endomyocardial fibrosis 10.3 IL10 TNF
21 nasal cavity disease 10.3 IL10 IL13
22 myelitis 10.3 IL9 TNF
23 multifocal choroiditis 10.3 IL10 TNF
24 choroiditis 10.3 IL10 TNF
25 allergic contact dermatitis 10.3 IL10 TNF
26 contact dermatitis 10.3 IL10 TNF
27 transient hypogammaglobulinemia 10.3 IL10 TNF
28 cow milk allergy 10.2 IL10 TNF
29 idiopathic achalasia 10.2 IL10 TNF
30 mucocutaneous leishmaniasis 10.2 IL10 TNF
31 chronic graft versus host disease 10.2 IL10 TNF
32 clonorchiasis 10.2 IL10 TNF
33 ancylostomiasis 10.2
34 keratoconjunctivitis 10.2 IL13 TNF
35 autoimmune gastritis 10.2 IL10 TNF
36 autoimmune disease of eyes, ear, nose and throat 10.2 IL10 TNF
37 intermediate uveitis 10.2 IL10 TNF
38 orofacial granulomatosis 10.2 IL10 TNF
39 transverse myelitis 10.2 IL10 TNF
40 post-transplant lymphoproliferative disease 10.2 IL10 TNF
41 primary systemic mycosis 10.2 IL10 TNF
42 multidrug-resistant tuberculosis 10.2 IL10 TNF
43 poliomyelitis 10.2 IL10 TNF
44 eales disease 10.2 IL10 TNF
45 hemorrhagic fever 10.2 IL10 TNF
46 spotted fever 10.2 IL10 TNF
47 coccidiosis 10.2 IL10 TNF
48 hematopoietic stem cell transplantation 10.2 IL10 TNF
49 aseptic meningitis 10.2 IL10 TNF
50 panuveitis 10.2 IL10 TNF

Graphical network of the top 20 diseases related to Trichuriasis:



Diseases related to Trichuriasis
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Symptoms & Phenotypes for Trichuriasis

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Symptoms:

12
  • • abdominal pain
  • • diarrhea
  • • rectal prolapse
  • • growth retardation

MGI Mouse Phenotypes related to Trichuriasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 IDO1 IL10 IL13 IL9 TNF UCP2
2 immune system MP:0005387 9.1 IDO1 IL10 IL13 IL9 TNF UCP2
Sources

Drugs & Therapeutics for Trichuriasis

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Drugs for Trichuriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrantel Approved, Vet_approved Phase 4 15686-83-6
2
Piperazine Approved, Vet_approved Phase 4,Phase 3 110-85-0 4837
3
Sodium Citrate Approved, Investigational Phase 4,Phase 3 68-04-2
4
Mebendazole Approved, Vet_approved Phase 4,Phase 3,Not Applicable 31431-39-7 4030
5
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 54965-21-8 2082
6
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
7 Neuromuscular Depolarizing Agents Phase 4
8 Piperazine citrate Phase 4,Phase 3
9 Neuromuscular Agents Phase 4
10 Pyrantel Pamoate Phase 4
11 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Not Applicable
12 Oxantel Phase 4
13 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Antimitotic Agents Phase 4,Phase 3,Phase 2,Not Applicable
15 DMP 777 Phase 4,Phase 3 157341-41-8
16 Neuromuscular Blocking Agents Phase 4
17 Anthelmintics Phase 4,Phase 3,Phase 2,Not Applicable
18 Citrate Phase 4,Phase 3
19 Peripheral Nervous System Agents Phase 4
20 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Adjuvants, Immunologic Phase 4
22 Immunologic Factors Phase 4,Phase 2
23 Antirheumatic Agents Phase 4
24
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3,Not Applicable 70288-86-7 6474909
25
Oxfendazole Investigational, Vet_approved Phase 2 53716-50-0 40854
26 Milbemycin Phase 2
27 Vaccines Phase 2
28 Cayenne Phase 2
29 Pharmaceutical Solutions Phase 2
30 Anti-Inflammatory Agents Phase 2
31
Praziquantel Approved, Investigational, Vet_approved Not Applicable 55268-74-1 4891

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Five Anthelmintic Regimes Against Trichuris Trichiura Infections in Schoolchildren in Jimma, Ethiopia Completed NCT01327469 Phase 4 Albendazole, 2 x 400mg;Albendazole 400mg;Mebendazole 500mg;Mebendazole 2 x 500mg;Pyrantel-oxantel + mebendazole
2 Efficacy Albendazole and Levamisole Against STH on Unguja Completed NCT00659997 Phase 4 Albendazole;Levamisole
3 A Safety Study of Mebendazole in Children 2 to 10 Years of Age Completed NCT01173562 Phase 3 Mebendazole
4 Efficacy and Safety of IVM/ALB Co-administration Not yet recruiting NCT03527732 Phase 2, Phase 3 Albendazole;Albendazole and Ivermectin
5 Efficacy and Safety of Ascending Dosages of Moxidectin and Moxidectin-albendazole Against Trichuris Trichiura Completed NCT03501251 Phase 2 Moxidectin 8mg;Moxidectin 8 mg + albendazole 400 mg;Moxidectin 16 mg;Moxidectin 16 mg + albendazole 400 mg;Moxidectin 24 mg;Moxidectin 24 mg + albendazole 400 mg
6 Inoculating Celiac Disease Patients With the Human Hookworm Necator Americanus: Evaluating Immunity and Gluten-sensitivity Completed NCT00671138 Phase 2
7 Trichuris Suis Ova (TSO) Suspension Versus Placebo in Active Crohn's Disease Completed NCT01279577 Phase 2 Low dose TSO;Medium dose TSO;High dose TSO;Placebo
8 Albendazole Dose Finding and Pharmacokinetics in Children and Adults Recruiting NCT03527745 Phase 2 Albendazole;Albendazole;Albendazole;Albendazole;Placebo
9 Probiotic Treatment of Ulcerative Colitis With Trichuris Suis Ova (TSO) Recruiting NCT03565939 Phase 2
10 Efficacy of Oxfendazole in the Treatment of Trichuris Trichiura Infection in Adults Not yet recruiting NCT03435718 Phase 2 Oxfendazole;Albendazole
11 Study of the Efficacy of Oxfendazole Compared to Albendazole in the Treatment of Trichuris Trichiura Infection in Adults Not yet recruiting NCT02636803 Phase 2 oxfendazole;albendazole
12 TSO in Pediatric Autistic Spectrum Disorders Terminated NCT01734941 Phase 2 TSO;Placebo
13 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
14 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment
15 Empiric Therapy of Helminth Co-infection to Reduce HIV-1 Disease Progression Completed NCT00507221 Not Applicable Albendazole;Praziquantel;Current standard of care in Kenya
16 Immune Modulation From Trichuris Suis Completed NCT03079700
17 Immune Modulation From Trichuris Trichiura Completed NCT02399683
18 Validation of POC-CCA Rapid Urine Test for Qualitative Detection of Schistosoma Japonicum Not yet recruiting NCT03870204
19 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Trichuriasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: trichuriasis

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Genetic Tests for Trichuriasis

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Anatomical Context for Trichuriasis

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MalaCards organs/tissues related to Trichuriasis:

42
Testes, Colon, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Trichuriasis:

20
Intestine In Humans
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Publications for Trichuriasis

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Articles related to Trichuriasis:

(show top 50) (show all 103)
# Title Authors Year
1
Trichuriasis. ( 29406051 )
2018
2
Trichuriasis. ( 30597113 )
2018
3
Clinical correlates of trichuriasis diagnosed at colonoscopy. ( 29058208 )
2017
4
A First Case of Human Trichuriasis from a Roman Lead Coffin in France. ( 27853119 )
2016
5
Current status of human hookworm infections, ascariasis, trichuriasis, schistosomiasis mekongi and other trematodiases in Lao People's Democratic Republic. ( 24515942 )
2014
6
Trichuriasis diagnosed by colonoscopy: case report and review of the literature spanning 22 years in mainland China. ( 23523058 )
2013
7
Growth reduction among primary schoolchildren with light trichuriasis in Malaysia treated with albendazole. ( 23682433 )
2013
8
Household social determinants of ascariasis and trichuriasis in North Central Venezuela. ( 24029148 )
2012
9
Utilizing environmental, socioeconomic data and GIS techniques to estimate the risk for ascariasis and trichuriasis in Minas Gerais, Brazil. ( 22041638 )
2012
10
Trichuriasis and low-iron status in schoolchildren from Northwest Mexico. ( 20700138 )
2010
11
Colonic transcriptional profiling in resistance and susceptibility to trichuriasis: phenotyping a chronic colitis and lessons for iatrogenic helminthosis. ( 20687192 )
2010
12
Trichuriasis colitis detected by Doppler sonography. ( 20571789 )
2010
13
Sonographic whipworm dance in trichuriasis. ( 19321687 )
2009
14
Whipworm infection resulting in eosinophilic colitis with occult intestinal bleeding. ( 17141232 )
2007
15
Computed tomographic findings of trichuriasis. ( 16830393 )
2006
16
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm. ( 16679166 )
2006
17
Immunity, immunoregulation and the ecology of trichuriasis and ascariasis. ( 15771679 )
2004
18
Comparative efficacy of albendazole and three brands of mebendazole in the treatment of ascariasis and trichuriasis. ( 15293971 )
2004
19
Prolonged treatment with albendazole for massive trichuriasis infection. ( 15545874 )
2004
20
A case of gastroenteritis associated with gastric trichuriasis. ( 12808334 )
2003
21
Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: the importance of IgE. ( 11865424 )
2002
22
Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru. ( 12055813 )
2002
23
A comparison of cellular and humoral immune responses to trichuroid derived antigens in human trichuriasis. ( 11874563 )
2002
24
Trichuriasis: localized inflammatory responses in the colon. ( 12236416 )
2002
25
Epidemiology of human geohelminth infections (ascariasis, trichuriasis and necatoriasis) in Lushui and Puer Counties, Yunnan Province, China. ( 11288999 )
2000
26
Efficacy of multiple dose mebendazole against trichuriasis in Thai and Karen patients. ( 11289001 )
2000
27
Use of Fenbendazole in Treating Trichuriasis in Colobus Monkeys. ( 23985619 )
1999
28
Randomised trial of albendazole and pyrantel in symptomless trichuriasis in children. ( 9798586 )
1998
29
Ascariasis, trichuriasis, and growth of schoolchildren in Northeastern Peninsular Malaysia. ( 10772554 )
1998
30
Trichuriasis associated to severe transient Coomb's-negative hemolytic anemia and macroscopic hematuria. ( 11995911 )
1995
31
Case in point. Trichuriasis. ( 7852465 )
1995
32
Transmission of trichuriasis in a sexual setting? ( 7849126 )
1994
33
Serum isotype responses after treatment of human trichuriasis. ( 7974688 )
1994
34
Basal and ACTH-stimulated plasma aldosterone concentrations are normal or increased in dogs with trichuriasis-associated pseudohypoadrenocorticism. ( 7983625 )
1994
35
Does ascariasis, trichuriasis and hookworm infection predispose to non-specific abdominal symptoms among adults in endemic areas? ( 8009635 )
1994
36
School performance, nutritional status and trichuriasis in Jamaican schoolchildren. ( 7531045 )
1994
37
Immunoepidemiology of intestinal helminth infections. 4. Immunopathology in trichuriasis: lessons from the mouse model. ( 7974660 )
1994
38
Do ascariasis, trichuriasis and hookworm infections predispose to non-specific abdominal symptoms among adults in endemic areas? ( 8273160 )
1993
39
A comparative study on the efficacy of albendazole and mebendazole in the treatment of ascariasis, hookworm infection and trichuriasis. ( 7939948 )
1993
40
Modulation of cytokine production and response phenotypes in murine trichuriasis. ( 1437236 )
1992
41
Ascariasis and trichuriasis in Cameroon. ( 2068772 )
1991
42
Helper T-cell subsets in mouse trichuriasis. ( 15463401 )
1991
43
Trichuris and trichuriasis in humans. ( 2683614 )
1989
44
Host predisposition to trichuriasis: the mouse--T. muris model. ( 2762038 )
1989
45
The evidence for predisposition to trichuriasis in humans: comparison of institutional and community studies. ( 3250338 )
1988
46
Gastric trichuriasis in a black and white colobus monkey. ( 3505990 )
1986
47
Epidemiological aspects of Trichuris and trichuriasis in Caribbean communities. ( 3299888 )
1986
48
Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis. ( 4039128 )
1985
49
Selective primary health care: strategies for control of disease in the developing world. XII. Ascariasis and trichuriasis. ( 6377443 )
1984
50
Benzimidazoles in the treatment of trichuriasis: a review. ( 6378109 )
1984
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Variations for Trichuriasis

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Expression for Trichuriasis

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Search GEO for disease gene expression data for Trichuriasis.
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Pathways for Trichuriasis

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Pathways related to Trichuriasis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 1 38
Show member pathways
 12.58 IL10 IL13 IL9 TNF
2
Th17 cell differentiation 38
Show member pathways
 12.31 IL10 IL13 TNF
3
NF-kappaB Signaling 4
12.27 IDO1 IL10 TNF
4
T cell receptor signaling pathway 38
Show member pathways
 12.14 IL10 IL9 TNF
5
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.11 IL10 IL13 IL9
6
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 11.99 IL10 IL13 IL9 TNF
7
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.91 IL10 IL13 TNF
8
Interleukin-4 and 13 signaling 67
11.73 IL10 IL13 TNF
9
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.48 IL10 IL13 TNF
10
Interleukin-10 signaling 67
11.3 IL10 IL13 TNF
11
Malaria 38
11.27 IL10 TNF
12
Th2 Differentiation Pathway 66
11.24 IL10 IL13 IL9
13
IL-10 Pathway 65
11.09 IL10 TNF
14
African trypanosomiasis 38
11.07 IDO1 IL10 TNF
15
Development and heterogeneity of the ILC family 1
10.94 IL13 IL9 TNF
16
G-protein signaling_RhoB regulation pathway 23
10.9 IL10 IL13 IL9 TNF
17
Innate Lymphoid Cell Differentiation Pathways 66
10.83 IL10 IL13 IL9 TNF
18
Cytokines and Inflammatory Response 1
10.79 IL10 IL13 TNF
19
G-protein signaling_Rap2B regulation pathway 23
10.71 IL10 IL13 IL9 TNF
20
OX40 Pathway 65
10.55 IL10 IL13 IL9
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GO Terms for Trichuriasis

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Biological processes related to Trichuriasis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.76 IL10 IL13 TNF
2 immune response GO:0006955 9.73 IL10 IL13 IL9 TNF
3 response to lipopolysaccharide GO:0032496 9.65 IDO1 IL10 IL13
4 regulation of signaling receptor activity GO:0010469 9.62 IL10 IL13 IL9 TNF
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.6 IL13 TNF
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.59 IL10 TNF
7 negative regulation of T cell proliferation GO:0042130 9.58 IDO1 IL10
8 liver regeneration GO:0097421 9.57 IL10 UCP2
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.56 IL10 IL13
10 negative regulation of mitotic cell cycle GO:0045930 9.55 IL10 TNF
11 negative regulation of interleukin-6 production GO:0032715 9.54 IL10 TNF
12 positive regulation of cytokine secretion GO:0050715 9.52 IL10 TNF
13 regulation of synapse organization GO:0050807 9.51 IL10 TNF
14 microglial cell activation GO:0001774 9.49 IL13 TNF
15 positive regulation of macrophage activation GO:0043032 9.46 IL10 IL13
16 negative regulation of growth of symbiont in host GO:0044130 9.4 IL10 TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.37 IL10 TNF
18 endothelial cell apoptotic process GO:0072577 9.26 IL10 TNF
19 negative regulation of cytokine secretion involved in immune response GO:0002740 9.16 IL10 TNF
20 inflammatory response GO:0006954 9.02 IDO1 IL10 IL13 IL9 TNF
21 receptor biosynthetic process GO:0032800 8.96 IL10 TNF

Molecular functions related to Trichuriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL13 IL9
2 cytokine activity GO:0005125 8.92 IL10 IL13 IL9 TNF
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Sources for Trichuriasis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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