MCID: TRC087
MIFTS: 41

Tricuspid Valve Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Disease

MalaCards integrated aliases for Tricuspid Valve Disease:

Name: Tricuspid Valve Disease 12 15
Rheumatic Tricuspid Valve Disease 12 73
Rheumatic Disease of Tricuspid Valve 12
Abnormality of the Tricuspid Valve 29
Rh. Tricuspid Valve Disease 12
Disease of Tricuspid Valve 12
Tricuspid Valve Disorder 73
Tricuspid Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050826
ICD10 33 I07 I07.9 I39.2
ICD9CM 35 397.0
SNOMED-CT 68 49699002

Summaries for Tricuspid Valve Disease

MalaCards based summary : Tricuspid Valve Disease, also known as rheumatic tricuspid valve disease, is related to ebstein anomaly and tricuspid valve stenosis. An important gene associated with Tricuspid Valve Disease is GATA6 (GATA Binding Protein 6), and among its related pathways/superpathways are Heart Development and Cardiomyocyte Differentiation through BMP Receptors. The drugs Cabergoline and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related phenotypes are cardiovascular system and embryo

Wikipedia : 76 The tricuspid valve, or right atrioventricular valve, is on the right dorsal side of the mammalian... more...

Related Diseases for Tricuspid Valve Disease

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 ebstein anomaly 31.9 GDF1 MYH7 NKX2-5 NKX2-6 NPPB
2 tricuspid valve stenosis 31.7 ARSE CRELD1 FBN1 HEY2 NKX2-6
3 tricuspid atresia 31.7 CRELD1 GDF1 HEY2 NKX2-6
4 tricuspid valve insufficiency 31.0 ACVRL1 ARSE CRELD1 FBN1 MC3R NPPB
5 transposition of the great arteries 29.8 GDF1 NKX2-5 ZIC3
6 heart disease 28.9 CRELD1 GATA6 GDF1 MYH7 NKX2-5 NKX2-6
7 atrial septal defect 9 11.2
8 partial atrioventricular canal 10.2 CRELD1 GATA6
9 complete atrioventricular canal-ventricle hypoplasia syndrome 10.2 CRELD1 GATA6
10 pulmonary valve stenosis 10.2 CRELD1 NKX2-6
11 pulmonary valve disease 10.1 CRELD1 GATA6 NKX2-6
12 total anomalous pulmonary venous return 1 10.1 CRELD1 GDF1 NKX2-6
13 pulmonary valve insufficiency 10.1 NKX2-6 NPPB
14 dextro-looped transposition of the great arteries 10.1 GDF1 NKX2-6 ZIC3
15 cardiac tamponade 10.1 ACVRL1 NPPB
16 toxic myocarditis 10.0 NPPB ZIC3
17 pericardium disease 10.0 ACVRL1 ZIC3
18 mitral valve stenosis 10.0 ACVRL1 CRELD1 NPPB
19 aortic valve insufficiency 10.0 FBN1 NKX2-6 NPPB
20 patent foramen ovale 10.0 GATA6 NKX2-5 NKX2-6
21 familial atrial fibrillation 10.0 GATA6 NKX2-5 NKX2-6
22 visceral heterotaxy 10.0 CRELD1 GDF1 NKX2-6 ZIC3
23 pulmonary hypertension, primary, 1 10.0 ACVRL1 FBN1 NPPB
24 aortic valve disease 2 10.0 MYH7 NKX2-6 NPPB
25 acute cor pulmonale 10.0 NPPB PDZK1IP1
26 acute pulmonary heart disease 10.0 NPPB PDZK1IP1
27 diaphragmatic eventration 9.9 FBN1 NKX2-6
28 conotruncal heart malformations 9.9 GATA6 GDF1 NKX2-5 NKX2-6
29 hypoplastic left heart syndrome 9.9 NKX2-5 NKX2-6 NPPB
30 char syndrome 9.9 FBN1 NKX2-5
31 infective endocarditis 9.9
32 endocarditis 9.9
33 antiphospholipid syndrome 9.9
34 mitral valve disease 9.9
35 carcinoid syndrome 9.9
36 congenitally corrected transposition of the great arteries 9.9
37 double discordia 9.9
38 depression 9.9
39 wolff-parkinson-white syndrome 9.9 MYH7 NKX2-5 NPPB
40 atrioventricular septal defect 9.9 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6
41 mitral valve insufficiency 9.8 CRELD1 FBN1 NPPB PDZK1IP1
42 heart septal defect 9.7 ACVRL1 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6
43 atrial heart septal defect 9.7 ACVRL1 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6
44 aortic valve disease 1 9.7 CRELD1 FBN1 NKX2-5 NKX2-6 NPPB
45 double outlet right ventricle 9.7 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6 ZIC3
46 patent ductus arteriosus 1 9.7 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6 NPPB
47 ventricular septal defect 9.5 GATA6 GDF1 MYH7 NKX2-5 NKX2-6 NPPB
48 heart valve disease 9.4 ARSE CRELD1 FBN1 NKX2-6 NPPB PDZK1IP1
49 tetralogy of fallot 9.3 CRELD1 FBN1 GATA6 GDF1 HEY2 NKX2-5

Comorbidity relations with Tricuspid Valve Disease via Phenotypic Disease Network (PDN): (show all 40)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Aortic Valve Disease 1
Aortic Valve Insufficiency Bronchitis
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Intermediate Coronary Syndrome
Intracranial Embolism Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Mitral Valve Disease Mitral Valve Stenosis
Nutmeg Liver Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Pulmonary Valve Disease
Respiratory Failure Rheumatic Heart Disease
Rheumatic Pulmonary Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Tricuspid Valve Disease:



Diseases related to Tricuspid Valve Disease

Symptoms & Phenotypes for Tricuspid Valve Disease

MGI Mouse Phenotypes related to Tricuspid Valve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 ACVRL1 CRELD1 FBN1 GATA6 GDF1 HEY2
2 embryo MP:0005380 9.91 ACVRL1 CRELD1 FBN1 GATA6 GDF1 HEY2
3 craniofacial MP:0005382 9.87 ACVRL1 CRELD1 FBN1 GDF1 HEY2 NKX2-5
4 growth/size/body region MP:0005378 9.81 ACVRL1 FBN1 GATA6 GDF1 HEY2 MC3R
5 muscle MP:0005369 9.43 ACVRL1 FBN1 GATA6 HEY2 MYH7 NKX2-5
6 respiratory system MP:0005388 9.23 ACVRL1 FBN1 GATA6 GDF1 HEY2 NKX2-5

Drugs & Therapeutics for Tricuspid Valve Disease

Drugs for Tricuspid Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cabergoline Approved 81409-90-7 54746
2
Dopamine Approved 51-61-6, 62-31-7 681
3
Levodopa Approved 59-92-7 6047
4 Dopamine Agents
5 Peripheral Nervous System Agents
6 Sympathomimetics
7 Dopamine agonists
8 Cardiotonic Agents
9 Protective Agents
10 Autonomic Agents
11 Neurotransmitter Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cardiovascular Toxicity Induced by Antitumoral Drugs: Risk Assessment and Early Diagnosis. CARDIOTOX Registry Unknown status NCT02039622
2 Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation Completed NCT03239262 Not Applicable
3 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
4 CorMatrix Cor TRICUSPID ECM Valve Replacement Study Recruiting NCT02397668 Not Applicable
5 Characteristics and Prognosis of Moderate or Severe Tricuspid Regurgitation Recruiting NCT03546231
6 Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM) Recruiting NCT02996552 Not Applicable
7 International Multisite Transcatheter Tricuspid Valve Therapies Registry Recruiting NCT03416166
8 Pathogenetic Basis of Aortopathy and Aortic Valve Disease Recruiting NCT03440697
9 A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve Disease Active, not recruiting NCT01194362
10 Natural History of Melody Valve in the Mitral and Tricuspid Position Active, not recruiting NCT02505074

Search NIH Clinical Center for Tricuspid Valve Disease

Genetic Tests for Tricuspid Valve Disease

Genetic tests related to Tricuspid Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Tricuspid Valve 29

Anatomical Context for Tricuspid Valve Disease

MalaCards organs/tissues related to Tricuspid Valve Disease:

41
Heart, Lung

Publications for Tricuspid Valve Disease

Articles related to Tricuspid Valve Disease:

(show top 50) (show all 65)
# Title Authors Year
1
Response to: 'Congenital tricuspid valve disease can masquerade as primary idiopathic TR' by Rajpal. ( 29478037 )
2018
2
Periprocedural and perioperatory management of patients with tricuspid valve disease. ( 29642696 )
2018
3
Congenital tricuspid valve disease can masquerade as primary idiopathic tricuspid regurgitation. ( 29748394 )
2018
4
The other side of the coin in primary tricuspid valve disease: The incremental value of 3D echocardiography. ( 29853700 )
2018
5
Transcatheter Treatment of Tricuspid Valve Disease: An Unmet Need? The Surgical Point of View. ( 30083537 )
2018
6
Surgical Techniques for Tricuspid Valve Disease. ( 30234129 )
2018
7
Cardiac Computed Tomography and Magnetic Resonance Imaging in the Evaluation of Mitral and Tricuspid Valve Disease: Implications for Transcatheter Interventions. ( 28292860 )
2017
8
Percutaneous Treatment of the Tricuspid Valve Disease: New Hope for the "Forgotten" Valve. ( 28645836 )
2017
9
Single-site ventricular pacing via the coronary sinus in patients with tricuspid valve disease. ( 28339945 )
2017
10
Tricuspid valve disease. ( 28706876 )
2017
11
Transcatheter Tricuspid Valve-in-Valve Intervention for Degenerative Bioprosthetic Tricuspid Valve Disease. ( 28843367 )
2017
12
Right Atrial Dysfunction in the Fetus with Severely Regurgitant Tricuspid Valve Disease: A Potential Source of Cardiovascular Compromise. ( 28410946 )
2017
13
How to Treat Tricuspid Valve Disease: What's New on the Horizon? ( 28290005 )
2017
14
Multi-site multi-polar left ventricular pacing through persistent left superior vena cava in tricuspid valve disease. ( 29192594 )
2017
15
Non-functional tricuspid valve disease. ( 28706863 )
2017
16
Radial Multi-Site, Longitudinal Multi-Polar Epicardial Left Ventricular Pacing In Tricuspid Valve Disease. ( 27698523 )
2016
17
Contemporary Outcomes and Factors Associated With Mortality After a Fetal or Neonatal Diagnosis of Ebstein Anomaly and Tricuspid Valve Disease. ( 27476984 )
2016
18
Diagnosis and treatment of tricuspid valve disease: current and future perspectives. ( 27048553 )
2016
19
Spectral Doppler of the Hepatic Veins in Tricuspid Valve Disease. ( 25250676 )
2014
20
Echo diagnosis of rheumatic tricuspid valve disease. ( 24495168 )
2014
21
Massive cardiac atriomegaly in tricuspid valve disease. ( 24269360 )
2014
22
Surgical treatment of organic and functional tricuspid valve disease. ( 24774120 )
2013
23
Evidence-based surgical management of acquired tricuspid valve disease. ( 23399976 )
2013
24
Incidental aortic valve calcification on CT scans: significance for bicuspid and tricuspid valve disease. ( 22104287 )
2012
25
Carcinoid tricuspid valve disease: incremental value of three-dimensional echocardiography. ( 22113204 )
2012
26
Repair of rheumatic tricuspid valve disease: predictors of very long-term mortality and reoperation. ( 20667339 )
2010
27
Coronary sinus dilatation. A simple additional echocardiographic indicator of severe rheumatic mitral and tricuspid valve disease. ( 20174730 )
2010
28
Rheumatic tricuspid valve disease: an evidence-based systematic overview. ( 20583402 )
2010
29
Tricuspid valve disease: pathophysiology and optimal management. ( 19410682 )
2009
30
Valve repair with autologous pericardium for organic lesions in rheumatic tricuspid valve disease. ( 19231380 )
2009
31
Tricuspid valve disease. ( 18222317 )
2008
32
Surgery for rheumatic tricuspid valve disease: a 30-year experience. ( 18692660 )
2008
33
Left ventricular myocardial performance in the fetus with severe tricuspid valve disease and tricuspid insufficiency. ( 15731988 )
2005
34
Tricuspid valve disease: tricuspid valve complex perspective. ( 11979238 )
2002
35
Ventricular pacing in the presence of tricuspid valve disease. ( 11915977 )
2002
36
Congenital Heart Surgery Nomenclature and Database Project: Ebstein's anomaly and tricuspid valve disease. ( 10798422 )
2000
37
Juvenile tricuspid stenosis and rheumatic tricuspid valve disease: an echocardiographic study. ( 10636636 )
1999
38
Isolated tricuspid valve disease in antiphospholipid syndrome. ( 10483018 )
1999
39
Progressive tricuspid valve disease in patients with congenitally corrected transposition of the great arteries. ( 9737520 )
1998
40
The histology of the lung in neonates with tricuspid valve disease and gross cardiomegaly due to severe regurgitation. ( 9565504 )
1998
41
Tricuspid valve disease. Clinical evaluation, physiopathology, and management. ( 9742330 )
1998
42
Isolated tricuspid valve disease in a patient with elevated levels of anticardiolipin antibodies. ( 9130436 )
1997
43
Rheumatic mitral and tricuspid valve disease. ( 9183050 )
1997
44
Extracardiac right atrium-to-right ventricle homograft for uncorrectable tricuspid valve disease. ( 9205196 )
1997
45
Aspects of tricuspid valve disease, heart failure and the "restriction-dilatation syndrome". ( 8562116 )
1995
46
Right ventricular volume overload results in depression of left ventricular ejection fraction. Implications for the surgical management of tricuspid valve disease. ( 7955255 )
1994
47
Tricuspid valve disease with significant tricuspid insufficiency in the fetus: diagnosis and outcome. ( 1987222 )
1991
48
Evaluation and management of tricuspid valve disease. ( 2054825 )
1991
49
Infective endocarditis complicating tricuspid valve disease in the carcinoid syndrome. ( 3128367 )
1988
50
A review of surgery for acquired tricuspid valve disease, including an assessment of the stented semilunar homograft valve, and the results of operation for multivalvular heart disease. ( 3415582 )
1988

Variations for Tricuspid Valve Disease

Expression for Tricuspid Valve Disease

Search GEO for disease gene expression data for Tricuspid Valve Disease.

Pathways for Tricuspid Valve Disease

Pathways related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 GATA6 HEY2 NKX2-5
2 10.14 MYH7 NKX2-5 NPPB

GO Terms for Tricuspid Valve Disease

Biological processes related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.92 ACVRL1 GATA6 HEY2 NKX2-5 ZIC3
2 transcription by RNA polymerase II GO:0006366 9.91 GATA6 HEY2 NKX2-5 NKX2-6 ZIC3
3 ventricular septum morphogenesis GO:0060412 9.65 HEY2 NKX2-5
4 BMP signaling pathway GO:0030509 9.65 ACVRL1 GDF1 NKX2-5
5 positive regulation of cardiac muscle cell proliferation GO:0060045 9.64 GATA6 HEY2
6 cellular response to BMP stimulus GO:0071773 9.64 ACVRL1 GATA6
7 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.63 HEY2 NKX2-5
8 positive regulation of BMP signaling pathway GO:0030513 9.63 ACVRL1 GATA6
9 regulation of heart rate GO:0002027 9.62 MC3R MYH7
10 outflow tract septum morphogenesis GO:0003148 9.62 GATA6 NKX2-5
11 cardiac muscle cell differentiation GO:0055007 9.61 GATA6 NKX2-5
12 embryonic heart tube development GO:0035050 9.61 NKX2-5 NKX2-6
13 cardiac muscle tissue development GO:0048738 9.6 GATA6 NKX2-5
14 pharyngeal system development GO:0060037 9.59 NKX2-5 NKX2-6
15 ventricular trabecula myocardium morphogenesis GO:0003222 9.58 HEY2 NKX2-5
16 adult heart development GO:0007512 9.58 MYH7 NKX2-5
17 pattern specification process GO:0007389 9.58 ACVRL1 HEY2 ZIC3
18 heart trabecula formation GO:0060347 9.57 HEY2 NKX2-5
19 smooth muscle cell differentiation GO:0051145 9.56 GATA6 HEY2
20 atrial septum morphogenesis GO:0060413 9.55 HEY2 NKX2-5
21 heart development GO:0007507 9.55 FBN1 GATA6 HEY2 NKX2-5 NKX2-6
22 regulation of blood pressure GO:0008217 9.54 ACVRL1 MC3R NPPB
23 cardiac ventricle morphogenesis GO:0003208 9.49 HEY2 NKX2-5
24 artery development GO:0060840 9.46 ACVRL1 HEY2
25 dorsal aorta morphogenesis GO:0035912 9.43 ACVRL1 HEY2
26 positive regulation of cardioblast differentiation GO:0051891 9.32 GATA6 NKX2-5
27 atrial cardiac muscle cell development GO:0055014 9.26 NKX2-5 NKX2-6
28 cardiac muscle hypertrophy in response to stress GO:0014898 9.13 GATA6 HEY2 MYH7
29 ventricular cardiac muscle cell development GO:0055015 8.8 HEY2 NKX2-5 NKX2-6
30 positive regulation of transcription by RNA polymerase II GO:0045944 10.01 ACVRL1 GATA6 HEY2 NKX2-5 NKX2-6 ZIC3

Molecular functions related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.55 GATA6 HEY2 NKX2-5 NKX2-6 ZIC3
2 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.26 GATA6 HEY2 NKX2-5 ZIC3
3 sequence-specific DNA binding GO:0043565 9.02 GATA6 HEY2 NKX2-5 NKX2-6 ZIC3

Sources for Tricuspid Valve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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