MCID: TRC087
MIFTS: 48

Tricuspid Valve Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Disease

MalaCards integrated aliases for Tricuspid Valve Disease:

Name: Tricuspid Valve Disease 12 15 17
Rheumatic Tricuspid Valve Disease 12 70
Rheumatic Disease of Tricuspid Valve 12
Abnormality of the Tricuspid Valve 29
Rh. Tricuspid Valve Disease 12
Disease of Tricuspid Valve 12
Tricuspid Valve Disorder 70
Tricuspid Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050826
ICD9CM 34 397.0
SNOMED-CT 67 49699002
ICD10 32 I07 I07.9 I39.2
UMLS 70 C0264776 C0264882

Summaries for Tricuspid Valve Disease

Disease Ontology : 12 A heart valve disease that is characterized by valvular insufficiency or valvular stenosis, located in tricuspid valve between the right atrium and right ventricle.

MalaCards based summary : Tricuspid Valve Disease, also known as rheumatic tricuspid valve disease, is related to tricuspid atresia and ebstein anomaly. An important gene associated with Tricuspid Valve Disease is GATA6 (GATA Binding Protein 6), and among its related pathways/superpathways are Cardiac conduction and cGMP-PKG signaling pathway. The drug Milrinone has been mentioned in the context of this disorder. Affiliated tissues include tricuspid valve between the right atrium, heart and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 The tricuspid valve, or right atrioventricular valve, is on the right dorsal side of the mammalian... more...

Related Diseases for Tricuspid Valve Disease

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 394)
# Related Disease Score Top Affiliating Genes
1 tricuspid atresia 32.2 TBX5 NKX2-5 GATA6
2 ebstein anomaly 31.7 TNNT2 TBX5 NKX2-5 MYH7 MYH6
3 endocarditis 30.7 TNNI3 F2 CRP ALB
4 infective endocarditis 30.5 TNNT2 TNNI3 F2 CRP
5 congenitally corrected transposition of the great arteries 30.4 TNNT2 NPPB
6 dextro-looped transposition of the great arteries 30.3 TBX5 NPPB NKX2-5
7 esophageal varix 30.3 F3 F2 ALB
8 sinoatrial node disease 30.3 TBX5 NKX2-5 MYH6
9 tricuspid valve insufficiency 30.2 TNNI3 REN PDE5A PAPPA NPPB MC3R
10 thrombophlebitis 30.2 F3 F2 CRP ALB
11 antiphospholipid syndrome 30.2 F3 F2 CRP
12 ventricular septal defect 30.1 TBX5 NPPB NKX2-5 MYH7 GATA6
13 atrioventricular block 29.9 TNNI3 TBX5 NPPB NKX2-5 MYH7 ACE
14 mitral valve disease 29.9 TNNI3 REN NPPB MYH6 FBN1 F3
15 heart septal defect 29.7 TNNT2 TBX5 NKX2-5 MYH6 GATA6 F2
16 mitral valve stenosis 29.7 REN NPPB F3 F2 EDN1 CRP
17 portal hypertension 29.5 F3 F2 EDN1 BMPR2 ALB ACE
18 pulmonary valve insufficiency 29.5 REN PDE5A NPPB FBN1 EDN1 CRP
19 aortic valve disease 1 29.4 TBX5 REN NKX2-5 MYH6 GATA6 FBN1
20 heart valve disease 29.4 TNNI3 REN NPPB NKX2-5 MYH6 FBN1
21 pulmonary hypertension 29.0 REN PDE5A NPPB F3 F2 EDN1
22 mitral valve insufficiency 28.5 TNNT2 TNNI3 TBX5 REN NPPB MYH7
23 tricuspid valve stenosis 11.2
24 atrial septal defect 9 11.2
25 acute dacryoadenitis 10.5 CRP ACE
26 mediastinum teratoma 10.5 CRP ACE
27 arteritic anterior ischemic optic neuropathy 10.5 F2 ACE
28 anterior scleritis 10.4 CRP ACE
29 chronic duodenal ileus 10.4 CRP ALB
30 multiple cranial nerve palsy 10.4 CRP ACE
31 posterior scleritis 10.4 CRP ACE
32 orbital osteomyelitis 10.4 F2 CRP
33 tolosa-hunt syndrome 10.4 CRP ACE
34 cerebral arteritis 10.4 EDN1 CRP
35 small intestine diverticulitis 10.4 F2 CRP
36 chronic orbital inflammation 10.4 CRP ACE
37 hepatoportal sclerosis 10.4 F2 ACE
38 pneumoconiosis due to talc 10.4 F2 ACE
39 cardiac tuberculosis 10.4 NPPB CRP ACE
40 vasculogenic impotence 10.4 PDE5A ACE
41 anterolateral myocardial infarction 10.4 NPPB ACE
42 non-a-e hepatitis 10.4 F2 ALB
43 hematocele of tunica vaginalis testis 10.4 F2 CRP
44 peptic ulcer perforation 10.4 CRP ALB
45 antipyrine metabolism 10.4 F2 ALB
46 pyridoxine deficiency anemia 10.4 F2 ACE
47 ankylosing spondylitis 3 10.4 CRP ALB
48 glossopharyngeal nerve disease 10.4 CRP ACE
49 bladder neck obstruction 10.4 PDE5A ACE
50 granulomatous angiitis 10.4 CRP ACE

Comorbidity relations with Tricuspid Valve Disease via Phenotypic Disease Network (PDN): (show all 38)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Aortic Valve Disease 1
Aortic Valve Insufficiency Bronchitis
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Disease Chronic Pulmonary Heart Disease
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypothyroidism
Intermediate Coronary Syndrome Intracranial Embolism
Iron Deficiency Anemia Kidney Disease
Mitral Valve Disease Mitral Valve Stenosis
Nutmeg Liver Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Pulmonary Valve Disease
Respiratory Failure Rheumatic Heart Disease
Rheumatic Pulmonary Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Tricuspid Valve Disease:



Diseases related to Tricuspid Valve Disease

Symptoms & Phenotypes for Tricuspid Valve Disease

MGI Mouse Phenotypes related to Tricuspid Valve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 ACE ALB BMPR2 CRP EDN1 F2
2 homeostasis/metabolism MP:0005376 10.25 ACE ALB BMPR2 CRP EDN1 F2
3 growth/size/body region MP:0005378 10.21 ACE BMPR2 EDN1 F2 F3 FBN1
4 mortality/aging MP:0010768 10.13 ACE ALB BMPR2 EDN1 F2 F3
5 embryo MP:0005380 10.1 ACE BMPR2 EDN1 F2 F3 FBN1
6 muscle MP:0005369 10 ALB BMPR2 EDN1 F2 F3 FBN1
7 normal MP:0002873 9.77 ALB BMPR2 EDN1 F2 F3 GATA6
8 respiratory system MP:0005388 9.23 BMPR2 F2 F3 FBN1 GATA6 MYH6

Drugs & Therapeutics for Tricuspid Valve Disease

Drugs for Tricuspid Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Milrinone Approved 78415-72-2 4197

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CorMatrix Cor TRICUSPID ECM Valve Replacement Safety and Early Feasibility Recruiting NCT02397668
2 Clinical and Echocardiographic Characteristics and Prognosis of trIcuspid regurgiTation (EPIT): Prospective and Retrospective Follow-up of a Cohort of Patients With Moderate or Severe Tricuspid Regurgitation Recruiting NCT03546231
3 Single-Center, Prospective, Open-Label Study Standardizing a Prehabilitation Protocol to Optimize Patients Prior to Undergoing Tricuspid Intervention Recruiting NCT04665583
4 Annuloplasty for the Treatment of Not-Severe Tricuspid Regurgitation in Patients Undergoing Surgery for Mitral Valve Disease: a Prospective, Spontaneous, Multicentre, Randomized Study Recruiting NCT02996552

Search NIH Clinical Center for Tricuspid Valve Disease

Genetic Tests for Tricuspid Valve Disease

Genetic tests related to Tricuspid Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Tricuspid Valve 29

Anatomical Context for Tricuspid Valve Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Tricuspid Valve Disease:

19
Tricuspid Valve Between The Right Atrium

MalaCards organs/tissues related to Tricuspid Valve Disease:

40
Heart, Kidney, Small Intestine, Placenta, Lung, Liver, Testis

Publications for Tricuspid Valve Disease

Articles related to Tricuspid Valve Disease:

(show top 50) (show all 266)
# Title Authors PMID Year
1
Prevalence and Outcomes of Tricuspid Valve Disease in Patients Undergoing Mitral Valve Surgery (from the Nationwide Inpatient Sample Database). 61
33476551 2021
2
Mechanical Versus Bioprosthetic Valve Replacement in the Tricuspid Valve Position: A Systematic Review and Meta-Analysis. 61
33229238 2021
3
Multi-Modality Imaging for Interventions in Tricuspid Valve Disease. 61
33634175 2021
4
Transcatheter Interventions for Tricuspid Valve Disease: What to Do and Who to Do it On. 61
33493660 2021
5
Healthcare utilization in clinically significant tricuspid regurgitation patients with and without heart failure. 61
33174767 2021
6
IMPULSE: the impact of gender on the presentation and management of aortic stenosis across Europe. 61
33419934 2021
7
[Surgical treatment of tricuspid valve disease due to permanent pacemaker lead]. 61
33142396 2020
8
Long-Term Follow-Up Of Isolated Tricuspid Valve Surgery. 61
33280291 2020
9
Ebstein's Anomaly of the Tricuspid Valve: an Overview of Pathology and Management. 61
33037480 2020
10
Long Term Outcomes Of Tricuspid Valve Replacement. 61
33280289 2020
11
Off-Pump Tricuspid Annuloplasty through a Direct Transatrial Approach: Early Results. 61
31683327 2020
12
Left-sided congenitally unguarded tricuspid valve with congenitally corrected transposition of the great arteries: A rare diagnosis confirmed by three-dimensional echocardiography. 61
32652546 2020
13
Temporal Trends in Prevalence of Tricuspid Valve Disease in Hospitalized Patients in the United States. 61
32303339 2020
14
Tricuspid valve replacement: an appraisal of 45 years of experience. 61
32221593 2020
15
Three-dimensional echocardiography for the assessment of the tricuspid valve. 61
32315483 2020
16
Transcatheter Tricuspid and Pulmonary Valve Repair and Replacement. 61
32379893 2020
17
Commentary: Tricuspid valve disease at the time of surgical aortic valve replacement: Treat it or leave it? 61
32417067 2020
18
Optimizing Cardiac CT Protocols for Comprehensive Acquisition Prior to Percutaneous MV and TV Repair/Replacement. 61
31422136 2020
19
Strategies for tricuspid valve repair. 61
33061193 2020
20
Mitral and Tricuspid Transcatheter Interventions Current Indications and Future Directions. 61
32500083 2020
21
Isolated surgical tricuspid repair versus replacement: meta-analysis of 15 069 patients. 61
32206317 2020
22
Clinical Profile and Management of Rheumatic Heart Disease in Children and Young Adults at a Tertiary Cardiac Center in Indonesia. 61
32903397 2020
23
Left ventricular pacing in patients with preexisting tricuspid valve disease. 61
31844475 2019
24
Carcinoid Tricuspid Valve Disease: Applications of Three Dimensional Transesophageal Echocardiography. 61
31766860 2019
25
Impact of Tricuspid Regurgitation in Patients With Heart Failure and Mitral Valve Disease from a Nationwide Cohort Study. 61
31331634 2019
26
Tricuspid valve disease: diagnosis, prognosis and management of a rapidly evolving field. 61
30988448 2019
27
Current status and future perspective of structural heart disease intervention. 61
30955999 2019
28
Etiology of tricuspid valve disease is a predictor of bradyarrhythmia after tricuspid valve surgery. 61
30938919 2019
29
Transcatheter Tricuspid Valve Interventions: Current Approaches and Future Perspectives. 61
31037717 2019
30
Tricuspid Valve Imaging and Intervention in Pediatric and Adult Patients With Congenital Heart Disease. 61
30947906 2019
31
Transcatheter heart valve interventions: where are we? Where are we going? 61
30608523 2019
32
Tricuspid Valve Disease: The "Forgotten Valve". 61
31238310 2019
33
Tricuspid valve surgery: repair and replacement. 61
29642693 2018
34
Periprocedural and perioperatory management of patients with tricuspid valve disease. 61
29642696 2018
35
Percutaneous tricuspid valve replacement: orthotopic and heterotopic valves. 61
29589668 2018
36
Response to: 'Congenital tricuspid valve disease can masquerade as primary idiopathic TR' by Rajpal. 61
29478037 2018
37
Contemporary management and outcomes in congenitally corrected transposition of the great arteries. 61
29326110 2018
38
Sutureless aortic valve replacement with concomitant valvular surgery. 61
29551538 2018
39
Congenital tricuspid valve disease can masquerade as primary idiopathic tricuspid regurgitation. 61
29748394 2018
40
The other side of the coin in primary tricuspid valve disease: The incremental value of 3D echocardiography. 61
29853700 2018
41
Preoperative Right-Sided Cardiac Congestion Is Associated with Gastrointestinal Bleeding in Patients with Continuous-Flow Left Ventricular Assist Devices. 61
29417325 2018
42
Transcatheter Tricuspid Valve-in-Valve Intervention for Degenerative Bioprosthetic Tricuspid Valve Disease. 61
28843367 2018
43
Single-site ventricular pacing via the coronary sinus in patients with tricuspid valve disease. 61
28339945 2018
44
Results and factors associated with adverse outcome after tricuspid valve replacement. 61
29589379 2018
45
The FORMA Repair System. 61
29157523 2018
46
Surgical Techniques for Tricuspid Valve Disease. 61
30234129 2018
47
Transcatheter Treatment of Tricuspid Valve Disease: An Unmet Need? The Surgical Point of View. 61
30083537 2018
48
Periareolar Access for Minimally Invasive Cardiac Surgery: The Brazilian Technique. 61
29432360 2018
49
Pattern and Extent of Tricuspid Valve Involvement in Chronic Rheumatic Heart Disease. 61
29459602 2018
50
Perioperative predictors of permanent pacing and long-term dependence following tricuspid valve surgery: a multicentre analysis. 61
28073887 2017

Variations for Tricuspid Valve Disease

Expression for Tricuspid Valve Disease

Search GEO for disease gene expression data for Tricuspid Valve Disease.

Pathways for Tricuspid Valve Disease

Pathways related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 TNNT2 TNNI3 TBX5 NKX2-5 MYH6
2
Show member pathways
12.35 TNNT2 TNNI3 PDE5A NPPB MYH7 MYH6
3
Show member pathways
12.3 TBX5 NPPB NKX2-5 MYH7 BMPR2
4
Show member pathways
11.9 TNNT2 TNNI3 MYH7 MYH6 EDN1 ACE
5 11.84 TNNT2 TNNI3 TBX5 NKX2-5 ALB
6 11.71 TNNT2 TNNI3 TBX5 NKX2-5
7 11.64 TNNT2 TNNI3 MYH7 MYH6
8 11.53 TNNT2 TNNI3 MYH6
9 11.49 REN EDN1 ACE
10 11.22 TBX5 NKX2-5 GATA6 BMPR2
11 10.75 TNNT2 TNNI3 TBX5 NKX2-5 MYH6
12 10.6 NPPB NKX2-5 MYH7 BMPR2

GO Terms for Tricuspid Valve Disease

Cellular components related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 REN PAPPA NPPB FBN1 F3 F2
2 sarcomere GO:0030017 9.46 TNNT2 TNNI3 MYH7 MYH6
3 troponin complex GO:0005861 9.4 TNNT2 TNNI3
4 cardiac myofibril GO:0097512 9.37 TNNT2 TNNI3
5 extracellular space GO:0005615 9.36 REN PAPPA NPPB FBN1 F3 F2
6 cardiac Troponin complex GO:1990584 9.26 TNNT2 TNNI3
7 myofibril GO:0030016 9.26 TNNT2 TNNI3 MYH7 MYH6

Biological processes related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.91 TNNI3 TBX5 NKX2-5 FBN1 EDN1
2 cellular protein metabolic process GO:0044267 9.89 PAPPA GATA6 FBN1 F2 ALB
3 muscle contraction GO:0006936 9.84 TNNT2 TNNI3 MYH7 MYH6
4 regulation of heart rate GO:0002027 9.72 MYH7 MYH6 MC3R
5 outflow tract septum morphogenesis GO:0003148 9.7 NKX2-5 GATA6 BMPR2
6 cardiac muscle cell differentiation GO:0055007 9.65 TBX5 NKX2-5 GATA6
7 striated muscle contraction GO:0006941 9.63 TNNI3 MYH7 MYH6
8 muscle filament sliding GO:0030049 9.62 TNNT2 TNNI3 MYH7 MYH6
9 cardiac muscle hypertrophy in response to stress GO:0014898 9.61 MYH7 MYH6 GATA6
10 atrioventricular valve morphogenesis GO:0003181 9.6 TBX5 BMPR2
11 negative regulation of systemic arterial blood pressure GO:0003085 9.59 NPPB BMPR2
12 negative regulation of ATPase activity GO:0032780 9.58 TNNT2 TNNI3
13 angiotensin maturation GO:0002003 9.58 REN ACE
14 adult heart development GO:0007512 9.58 NKX2-5 MYH7 MYH6
15 endocardial cushion development GO:0003197 9.57 TBX5 BMPR2
16 body fluid secretion GO:0007589 9.56 NPPB EDN1
17 atrial septum morphogenesis GO:0060413 9.54 TBX5 NKX2-5 BMPR2
18 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.46 TNNT2 TNNI3 MYH7 MYH6
19 positive regulation of cardioblast differentiation GO:0051891 9.43 TBX5 NKX2-5 GATA6
20 cardiac muscle contraction GO:0060048 9.35 TNNT2 TNNI3 NKX2-5 MYH7 MYH6
21 regulation of blood pressure GO:0008217 9.1 REN NPPB MYH6 MC3R EDN1 ACE

Molecular functions related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.62 TNNT2 TNNI3 TBX5 REN PDE5A PAPPA
2 actin binding GO:0003779 9.55 TNNT2 TNNI3 MYH7 MYH6 ACE
3 troponin C binding GO:0030172 8.96 TNNT2 TNNI3

Sources for Tricuspid Valve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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