MCID: TRC087
MIFTS: 43

Tricuspid Valve Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Disease

MalaCards integrated aliases for Tricuspid Valve Disease:

Name: Tricuspid Valve Disease 12 15 17
Rheumatic Tricuspid Valve Disease 12 74
Rheumatic Disease of Tricuspid Valve 12
Abnormality of the Tricuspid Valve 30
Rh. Tricuspid Valve Disease 12
Disease of Tricuspid Valve 12
Tricuspid Valve Disorder 74
Tricuspid Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050826
ICD9CM 36 397.0
SNOMED-CT 69 49699002
ICD10 34 I07 I07.9 I39.2

Summaries for Tricuspid Valve Disease

Disease Ontology : 12 A heart valve disease that is characterized by valvular insufficiency or valvular stenosis, located in tricuspid valve between the right atrium and right ventricle.

MalaCards based summary : Tricuspid Valve Disease, also known as rheumatic tricuspid valve disease, is related to ebstein anomaly and tricuspid valve stenosis. An important gene associated with Tricuspid Valve Disease is GATA6 (GATA Binding Protein 6), and among its related pathways/superpathways are Heart Development and Cardiomyocyte Differentiation through BMP Receptors. The drugs Levodopa and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include tricuspid valve between the right atrium, and related phenotypes are cardiovascular system and muscle

Wikipedia : 77 The tricuspid valve, or right atrioventricular valve, is on the right dorsal side of the mammalian... more...

Related Diseases for Tricuspid Valve Disease

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 ebstein anomaly 32.6 MYH7 NKX2-5 NPPB
2 tricuspid valve stenosis 32.3 ARSE CA6 FBN1 HEY2
3 tricuspid atresia 32.0 HEY2 ZFPM2
4 tricuspid valve insufficiency 30.3 ARSE CA6 CPB1 FBN1 MC3R NPPB
5 transposition of the great arteries 30.2 NKX2-5 ZIC3
6 ventricular septal defect 29.5 GATA6 MYH7 NKX2-5 NPPB ZFPM2 ZIC3
7 heart disease 29.4 GATA6 MYH6 MYH7 NKX2-5 NPPB ZIC3
8 atrial septal defect 9 11.2
9 myosin storage myopathy 10.3 MYH6 MYH7
10 myopathy, distal, 1 10.3 MYH6 MYH7
11 patent ductus arteriosus 1 10.2 GATA6 NKX2-5 NPPB
12 muscle hypertrophy 10.2 GATA6 MYH6 MYH7
13 atrial heart septal defect 10.2 GATA6 MYH6 NKX2-5
14 wolff-parkinson-white syndrome 10.2 MYH7 NKX2-5 NPPB
15 holt-oram syndrome 10.2 MYH6 MYH7 NKX2-5
16 toxic myocarditis 10.2 NPPB ZIC3
17 patent foramen ovale 10.2 GATA6 MYH6 NKX2-5
18 atrial standstill 1 10.2 MYH6 MYH7 NPPB
19 hypoplastic left heart syndrome 10.1 MYH6 NKX2-5 NPPB
20 scapuloperoneal myopathy 10.1 MYH6 MYH7
21 congestive heart failure 10.1 MYH6 MYH7 NPPB
22 conotruncal heart malformations 10.1 GATA6 NKX2-5 ZFPM2
23 third-degree atrioventricular block 10.1 NPPB SLC35B2
24 left ventricular noncompaction 10.1 MYH6 MYH7 NKX2-5
25 aortic valve disease 1 10.1 FBN1 NKX2-5 NPPB
26 aortic valve insufficiency 10.0 FBN1 NPPB
27 char syndrome 9.9 CPB1 FBN1 NKX2-5
28 infective endocarditis 9.9
29 endocarditis 9.9
30 antiphospholipid syndrome 9.9
31 mitral valve disease 9.9
32 rere-related disorders 9.9
33 carcinoid syndrome 9.9
34 congenitally corrected transposition of the great arteries 9.9
35 double discordia 9.9
36 depression 9.9
37 double outlet right ventricle 9.9 GATA6 NKX2-5 ZFPM2 ZIC3
38 acute cor pulmonale 9.9 NPPB PDZK1IP1
39 acute pulmonary heart disease 9.9 NPPB PDZK1IP1
40 mitral valve insufficiency 9.8 FBN1 NPPB PDZK1IP1
41 diaphragmatic eventration 9.8 FBN1 ZFPM2
42 heart septal defect 9.7 GATA6 NKX2-5 SLC35B2 ZFPM2
43 heart valve disease 9.6 ARSE FBN1 NPPB PDZK1IP1
44 tetralogy of fallot 9.5 FBN1 GATA6 HEY2 NKX2-5 NPPB ZFPM2

Comorbidity relations with Tricuspid Valve Disease via Phenotypic Disease Network (PDN): (show all 40)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Aortic Valve Disease 1
Aortic Valve Insufficiency Bronchitis
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Intermediate Coronary Syndrome
Intracranial Embolism Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Mitral Valve Disease Mitral Valve Stenosis
Nutmeg Liver Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Pulmonary Valve Disease
Respiratory Failure Rheumatic Heart Disease
Rheumatic Pulmonary Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Tricuspid Valve Disease:



Diseases related to Tricuspid Valve Disease

Symptoms & Phenotypes for Tricuspid Valve Disease

MGI Mouse Phenotypes related to Tricuspid Valve Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 FBN1 GATA6 HEY2 MYH6 MYH7 NKX2-5
2 muscle MP:0005369 9.5 FBN1 GATA6 HEY2 MYH6 MYH7 NKX2-5
3 respiratory system MP:0005388 9.17 FBN1 GATA6 HEY2 MYH6 NKX2-5 ZFPM2

Drugs & Therapeutics for Tricuspid Valve Disease

Drugs for Tricuspid Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levodopa Approved 59-92-7 6047
2
Dopamine Approved 62-31-7, 51-61-6 681
3
Cabergoline Approved 81409-90-7 54746
4
Magnesium Sulfate Approved, Investigational, Vet_approved Not Applicable 7487-88-9 24083
5
Dexlansoprazole Approved, Investigational Not Applicable 138530-94-6, 103577-45-3 9578005
6
Gabapentin Approved, Investigational Not Applicable 60142-96-3 3446
7
Lansoprazole Approved, Investigational Not Applicable 103577-45-3 3883
8
Bupivacaine Approved, Investigational Not Applicable 38396-39-3, 2180-92-9 2474
9
Acetaminophen Approved Not Applicable 103-90-2 1983
10
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
11
Ondansetron Approved Not Applicable 99614-02-5 4595
12
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
13 Cardiotonic Agents
14 Sympathomimetics
15 Protective Agents
16 Peripheral Nervous System Agents ,Not Applicable
17 Neurotransmitter Agents ,Not Applicable
18 Dopamine agonists
19 Dopamine Agents
20 Autonomic Agents ,Not Applicable
21 Hormone Antagonists Not Applicable
22 Analgesics Not Applicable
23 Antipyretics Not Applicable
24 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
25 Anti-Anxiety Agents Not Applicable
26 Excitatory Amino Acids Not Applicable
27 Excitatory Amino Acid Antagonists Not Applicable
28 Antacids Not Applicable
29 Serotonin Antagonists Not Applicable
30 Central Nervous System Depressants Not Applicable
31 Hormones Not Applicable
32 Opiate Alkaloids Not Applicable
33 Gastrointestinal Agents Not Applicable
34 Antiemetics Not Applicable
35 Psychotropic Drugs Not Applicable
36 Anti-Ulcer Agents Not Applicable
37 HIV Protease Inhibitors Not Applicable
38 Analgesics, Non-Narcotic Not Applicable
39
protease inhibitors Not Applicable
40 Antipruritics Not Applicable
41 Dermatologic Agents Not Applicable
42 Tranquilizing Agents Not Applicable
43 glucocorticoids Not Applicable
44 Antimanic Agents Not Applicable
45 Proton Pump Inhibitors Not Applicable
46 Anesthetics Not Applicable
47 Antineoplastic Agents, Hormonal Not Applicable
48 Anesthetics, Local Not Applicable
49 Anti-Inflammatory Agents Not Applicable
50 Serotonin Agents Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Cardiovascular Toxicity Induced by Antitumoral Drugs: Risk Assessment and Early Diagnosis. CARDIOTOX Registry Unknown status NCT02039622
2 Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation Completed NCT03239262 Not Applicable
3 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
4 CorMatrix Cor TRICUSPID ECM Valve Replacement Study Recruiting NCT02397668 Not Applicable
5 Characteristics and Prognosis of Moderate or Severe Tricuspid Regurgitation Recruiting NCT03546231
6 Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM) Recruiting NCT02996552 Not Applicable
7 International Multisite Transcatheter Tricuspid Valve Therapies Registry Recruiting NCT03416166
8 Enhanced Recovery After Cardiac Surgery Recruiting NCT03859102 Not Applicable Oral Gabapentin pre-op;Oral Lansoprazole pre-op;Intravenous Paracetamol intra-operatively;Intravenous Dexamethasone intra-operatively;Intravenous Ondansetron intra-operatively;Infiltration of surgical wounds with local anaesthetic;Intravenous Magnesium intra-operatively;Post-operative Gabapentin analgesia;Post-operative oral Paracetamol analgesia;Post-operative Ondansetron anti-emesis
9 Pathogenetic Basis of Aortopathy and Aortic Valve Disease Recruiting NCT03440697
10 A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve Disease Active, not recruiting NCT01194362
11 Natural History of Melody Valve in the Mitral and Tricuspid Position Active, not recruiting NCT02505074
12 Structural Heart and Valve Network PROSPECTIVE Registry Not yet recruiting NCT03928639

Search NIH Clinical Center for Tricuspid Valve Disease

Genetic Tests for Tricuspid Valve Disease

Genetic tests related to Tricuspid Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Tricuspid Valve 30

Anatomical Context for Tricuspid Valve Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Tricuspid Valve Disease:

20
Tricuspid Valve Between The Right Atrium

Publications for Tricuspid Valve Disease

Articles related to Tricuspid Valve Disease:

(show top 50) (show all 67)
# Title Authors Year
1
Etiology of tricuspid valve disease is a predictor of bradyarrhythmia after tricuspid valve surgery. ( 30938919 )
2019
2
Tricuspid valve disease: diagnosis, prognosis and management of a rapidly evolving field. ( 30988448 )
2019
3
Single-site ventricular pacing via the coronary sinus in patients with tricuspid valve disease. ( 28339945 )
2018
4
Transcatheter Tricuspid Valve-in-Valve Intervention for Degenerative Bioprosthetic Tricuspid Valve Disease. ( 28843367 )
2018
5
Response to: 'Congenital tricuspid valve disease can masquerade as primary idiopathic TR' by Rajpal. ( 29478037 )
2018
6
Periprocedural and perioperatory management of patients with tricuspid valve disease. ( 29642696 )
2018
7
Congenital tricuspid valve disease can masquerade as primary idiopathic tricuspid regurgitation. ( 29748394 )
2018
8
The other side of the coin in primary tricuspid valve disease: The incremental value of 3D echocardiography. ( 29853700 )
2018
9
Transcatheter Treatment of Tricuspid Valve Disease: An Unmet Need? The Surgical Point of View. ( 30083537 )
2018
10
Surgical Techniques for Tricuspid Valve Disease. ( 30234129 )
2018
11
How to Treat Tricuspid Valve Disease: What's New on the Horizon? ( 28290005 )
2017
12
Cardiac Computed Tomography and Magnetic Resonance Imaging in the Evaluation of Mitral and Tricuspid Valve Disease: Implications for Transcatheter Interventions. ( 28292860 )
2017
13
Right Atrial Dysfunction in the Fetus with Severely Regurgitant Tricuspid Valve Disease: A Potential Source of Cardiovascular Compromise. ( 28410946 )
2017
14
Percutaneous Treatment of the Tricuspid Valve Disease: New Hope for the "Forgotten" Valve. ( 28645836 )
2017
15
Non-functional tricuspid valve disease. ( 28706863 )
2017
16
Tricuspid valve disease. ( 28706876 )
2017
17
Multi-site multi-polar left ventricular pacing through persistent left superior vena cava in tricuspid valve disease. ( 29192594 )
2017
18
Contemporary Outcomes and Factors Associated With Mortality After a Fetal or Neonatal Diagnosis of Ebstein Anomaly and Tricuspid Valve Disease. ( 27476984 )
2016
19
Diagnosis and treatment of tricuspid valve disease: current and future perspectives. ( 27048553 )
2016
20
Radial Multi-Site, Longitudinal Multi-Polar Epicardial Left Ventricular Pacing In Tricuspid Valve Disease. ( 27698523 )
2016
21
Spectral Doppler of the hepatic veins in tricuspid valve disease. ( 25250676 )
2015
22
Massive cardiac atriomegaly in tricuspid valve disease. ( 24269360 )
2014
23
Echo diagnosis of rheumatic tricuspid valve disease. ( 24495168 )
2014
24
Evidence-based surgical management of acquired tricuspid valve disease. ( 23399976 )
2013
25
Surgical treatment of organic and functional tricuspid valve disease. ( 24774120 )
2013
26
Incidental aortic valve calcification on CT scans: significance for bicuspid and tricuspid valve disease. ( 22104287 )
2012
27
Carcinoid tricuspid valve disease: incremental value of three-dimensional echocardiography. ( 22113204 )
2012
28
Coronary sinus dilatation. A simple additional echocardiographic indicator of severe rheumatic mitral and tricuspid valve disease. ( 20174730 )
2010
29
Rheumatic tricuspid valve disease: an evidence-based systematic overview. ( 20583402 )
2010
30
Repair of rheumatic tricuspid valve disease: predictors of very long-term mortality and reoperation. ( 20667339 )
2010
31
Valve repair with autologous pericardium for organic lesions in rheumatic tricuspid valve disease. ( 19231380 )
2009
32
Tricuspid valve disease: pathophysiology and optimal management. ( 19410682 )
2009
33
Tricuspid valve disease. ( 18222317 )
2008
34
Surgery for rheumatic tricuspid valve disease: a 30-year experience. ( 18692660 )
2008
35
Left ventricular myocardial performance in the fetus with severe tricuspid valve disease and tricuspid insufficiency. ( 15731988 )
2005
36
Ventricular pacing in the presence of tricuspid valve disease. ( 11915977 )
2002
37
Tricuspid valve disease: tricuspid valve complex perspective. ( 11979238 )
2002
38
Congenital Heart Surgery Nomenclature and Database Project: Ebstein's anomaly and tricuspid valve disease. ( 10798422 )
2000
39
Isolated tricuspid valve disease in antiphospholipid syndrome. ( 10483018 )
1999
40
Juvenile tricuspid stenosis and rheumatic tricuspid valve disease: an echocardiographic study. ( 10636636 )
1999
41
Progressive tricuspid valve disease in patients with congenitally corrected transposition of the great arteries. ( 9737520 )
1998
42
The histology of the lung in neonates with tricuspid valve disease and gross cardiomegaly due to severe regurgitation. ( 9565504 )
1998
43
Tricuspid valve disease. Clinical evaluation, physiopathology, and management. ( 9742330 )
1998
44
Isolated tricuspid valve disease in a patient with elevated levels of anticardiolipin antibodies. ( 9130436 )
1997
45
Rheumatic mitral and tricuspid valve disease. ( 9183050 )
1997
46
Extracardiac right atrium-to-right ventricle homograft for uncorrectable tricuspid valve disease. ( 9205196 )
1997
47
Aspects of tricuspid valve disease, heart failure and the "restriction-dilatation syndrome". ( 8562116 )
1995
48
Right ventricular volume overload results in depression of left ventricular ejection fraction. Implications for the surgical management of tricuspid valve disease. ( 7955255 )
1994
49
Tricuspid valve disease with significant tricuspid insufficiency in the fetus: diagnosis and outcome. ( 1987222 )
1991
50
Evaluation and management of tricuspid valve disease. ( 2054825 )
1991

Variations for Tricuspid Valve Disease

Expression for Tricuspid Valve Disease

Search GEO for disease gene expression data for Tricuspid Valve Disease.

Pathways for Tricuspid Valve Disease

Pathways related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 GATA6 HEY2 NKX2-5
2 10.14 MYH7 NKX2-5 NPPB

GO Terms for Tricuspid Valve Disease

Cellular components related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myosin filament GO:0032982 8.96 MYH6 MYH7
2 muscle myosin complex GO:0005859 8.62 MYH6 MYH7

Biological processes related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.96 GATA6 HEY2 NKX2-5 ZFPM2 ZIC3
2 in utero embryonic development GO:0001701 9.8 GATA6 MYH6 ZFPM2
3 regulation of blood pressure GO:0008217 9.7 MC3R MYH6 NPPB
4 vasculogenesis GO:0001570 9.67 HEY2 NKX2-5 ZFPM2
5 cardiac muscle contraction GO:0060048 9.65 MYH6 MYH7 NKX2-5
6 ventricular septum morphogenesis GO:0060412 9.63 HEY2 NKX2-5 ZFPM2
7 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.62 HEY2 NKX2-5
8 cardiac muscle cell differentiation GO:0055007 9.62 GATA6 NKX2-5
9 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.61 MYH6 MYH7
10 regulation of the force of heart contraction GO:0002026 9.61 MYH6 MYH7
11 positive regulation of cardiac muscle cell proliferation GO:0060045 9.61 GATA6 HEY2 ZFPM2
12 striated muscle contraction GO:0006941 9.6 MYH6 MYH7
13 ventricular trabecula myocardium morphogenesis GO:0003222 9.59 HEY2 NKX2-5
14 heart trabecula formation GO:0060347 9.58 HEY2 NKX2-5
15 smooth muscle cell differentiation GO:0051145 9.58 GATA6 HEY2
16 regulation of heart rate GO:0002027 9.58 MC3R MYH6 MYH7
17 atrial septum morphogenesis GO:0060413 9.57 HEY2 NKX2-5
18 heart development GO:0007507 9.56 FBN1 HEY2 NKX2-5 ZFPM2
19 cardiac ventricle morphogenesis GO:0003208 9.55 HEY2 NKX2-5
20 ventricular cardiac muscle cell development GO:0055015 9.54 HEY2 NKX2-5
21 positive regulation of cardioblast differentiation GO:0051891 9.51 GATA6 NKX2-5
22 outflow tract septum morphogenesis GO:0003148 9.5 GATA6 NKX2-5 ZFPM2
23 right ventricular cardiac muscle tissue morphogenesis GO:0003221 9.37 NKX2-5 ZFPM2
24 cardiac muscle tissue development GO:0048738 9.33 GATA6 NKX2-5 ZFPM2
25 adult heart development GO:0007512 9.13 MYH6 MYH7 NKX2-5
26 cardiac muscle hypertrophy in response to stress GO:0014898 8.92 GATA6 HEY2 MYH6 MYH7

Molecular functions related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.26 GATA6 HEY2 NKX2-5 ZFPM2
2 microfilament motor activity GO:0000146 9.16 MYH6 MYH7
3 actin-dependent ATPase activity GO:0030898 8.62 MYH6 MYH7

Sources for Tricuspid Valve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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