Tricuspid Valve Disease

Categories: Blood diseases, Cardiovascular diseases
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Aliases & Classifications for Tricuspid Valve Disease

MalaCards integrated aliases for Tricuspid Valve Disease:

Name: Tricuspid Valve Disease 11 14 16 33
Rheumatic Tricuspid Valve Disease 11 71
Rheumatic Disease of Tricuspid Valve 11
Rh. Tricuspid Valve Disease 11
Disease of Tricuspid Valve 11
Tricuspid Valve Disorder 71
Tricuspid Disease 11


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Disease Ontology 11 DOID:0050826
ICD9CM 34 397.0
SNOMED-CT 68 49699002
ICD10 31 I07 I07.9 I39.2
UMLS 71 C0264776 C0264882

Summaries for Tricuspid Valve Disease

Disease Ontology: 11 A heart valve disease that is characterized by valvular insufficiency or valvular stenosis, located in tricuspid valve between the right atrium and right ventricle.

MalaCards based summary: Tricuspid Valve Disease, also known as rheumatic tricuspid valve disease, is related to tricuspid valve stenosis and ebstein anomaly. An important gene associated with Tricuspid Valve Disease is GATA6 (GATA Binding Protein 6), and among its related pathways/superpathways are Cardiac conduction and Human Embryonic Stem Cell Pluripotency. The drugs Bupivacaine and Magnesium sulfate have been mentioned in the context of this disorder. Affiliated tissues include tricuspid valve between the right atrium, heart and small intestine, and related phenotypes are muscle and homeostasis/metabolism

Related Diseases for Tricuspid Valve Disease

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 523)
# Related Disease Score Top Affiliating Genes
1 tricuspid valve stenosis 32.5 NPPB NKX2-5 F3
2 ebstein anomaly 32.3 NPPB NKX2-5 MYH7 MYH6
3 congenitally corrected transposition of the great arteries 30.7 TNNT2 NPPB
4 endocarditis 30.7 TNNT2 TNNI3 F2 CRP ALB
5 infective endocarditis 30.6 NPPB F3 F2 CRP ALB ACE
6 tricuspid valve insufficiency 30.6 TNNT2 TNNI3 REN PDE5A NR3C2 NPPB
7 persistent fetal circulation syndrome 30.4 PDE5A EDN1 ALB
8 thrombophlebitis 30.3 F3 F2 CRP ALB
9 antiphospholipid syndrome 30.2 F3 F2 CRP
10 ventricular septal defect 30.2 TNNT2 NPPB NKX2-5 MYH6 GATA6
11 esophageal varix 30.2 GPT F3 F2 CRP ALB
12 atrioventricular block 30.0 TNNT2 TNNI3 NPPB NKX2-5 MYH6 CRP
13 diaphragmatic hernia, congenital 30.0 PDE5A GATA6 FBN1 EDN1 CRP BMPR2
14 pulmonary hypertension 29.8 REN PDE5A NPPB NKX2-5 F3 EDN1
15 connective tissue disease 29.7 GPT FBN1 EDN1 CRP BMPR2 ALB
16 mitral valve stenosis 29.7 REN NR3C2 NPPB F3 F2 EDN1
17 heart septal defect 29.6 TNNT2 NPPB NKX2-5 MYH7 MYH6 GATA6
18 pulmonary valve insufficiency 29.6 REN PDE5A NPPB NKX2-5 FBN1 EDN1
19 aortic valve insufficiency 29.5 TNNI3 REN NPPB NKX2-5 FBN1 F3
20 portal hypertension 29.5 REN GPT F2 EDN1 BMPR2 ALB
21 aortic valve disease 1 29.5 REN NPPB NKX2-5 MYH6 GATA6 FBN1
22 aortic valve disease 2 29.5 TNNT2 TNNI3 REN NPPB NKX2-5 MYH7
23 congestive heart failure 29.4 TNNT2 TNNI3 REN PDE5A NR3C2 NPPB
24 mitral valve disease 29.3 TNNT2 TNNI3 REN NR3C2 NPPB MYH7
25 heart valve disease 29.1 TNNT2 TNNI3 REN NR3C2 NPPB NKX2-5
26 mitral valve insufficiency 28.9 TNNT2 TNNI3 REN NR3C2 NPPB MYH7
27 heart disease 28.2 TNNT2 TNNI3 REN PDE5A NR3C2 NPPB
28 tricuspid atresia 11.2
29 atrial septal defect 9 11.2
30 anterolateral myocardial infarction 10.5 NPPB ACE
31 mediastinum teratoma 10.4 CRP ACE
32 pyeloureteritis cystica 10.4 REN CRP
33 chronic duodenal ileus 10.4 CRP ALB
34 hypertensive nephropathy 10.4 ALB ACE
35 orbital osteomyelitis 10.4 F2 CRP
36 anterior scleritis 10.4 CRP ACE
37 multiple cranial nerve palsy 10.4 CRP ACE
38 ankylosing spondylitis 3 10.4 CRP ALB
39 posterior scleritis 10.4 CRP ACE
40 vasculogenic impotence 10.4 PDE5A ACE
41 hypoaldosteronism 10.4 REN ACE
42 pyridoxine deficiency anemia 10.4 F2 ACE
43 renal artery obstruction 10.4 REN ACE
44 toxic myocarditis 10.4 TNNI3 NPPB ACE
45 dipetalonemiasis 10.4 GPT ALB
46 bladder neck obstruction 10.4 PDE5A ACE
47 chronic intestinal vascular insufficiency 10.4 CRP ALB
48 acute vascular insufficiency of intestine 10.4 CRP ALB
49 cardiac sarcoidosis 10.4 NPPB CRP ACE
50 peptic ulcer perforation 10.4 CRP ALB

Comorbidity relations with Tricuspid Valve Disease via Phenotypic Disease Network (PDN): (show all 38)

Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Aortic Valve Disease 1
Aortic Valve Insufficiency Bronchitis
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Disease Chronic Pulmonary Heart Disease
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypothyroidism
Intermediate Coronary Syndrome Intracranial Embolism
Iron Deficiency Anemia Kidney Disease
Mitral Valve Disease Mitral Valve Stenosis
Nutmeg Liver Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Pulmonary Valve Disease
Respiratory Failure Rheumatic Heart Disease
Rheumatic Pulmonary Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Tricuspid Valve Disease:

Diseases related to Tricuspid Valve Disease

Symptoms & Phenotypes for Tricuspid Valve Disease

GenomeRNAi Phenotypes related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 ACE ALB BMPR2 CRP EDN1 F2
2 no effect GR00402-S-2 10.19 ACE ALB BMPR2 CRP EDN1 F2

MGI Mouse Phenotypes related to Tricuspid Valve Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 10.31 ALB BMPR2 EDN1 F2 F3 FBN1
2 homeostasis/metabolism MP:0005376 10.31 ACE ALB BMPR2 CRP EDN1 F2
3 normal MP:0002873 10.22 ALB BMPR2 EDN1 F2 F3 GATA6
4 growth/size/body region MP:0005378 10.21 ACE BMPR2 EDN1 F2 F3 FBN1
5 cardiovascular system MP:0005385 10.21 ACE ALB BMPR2 CRP EDN1 F2
6 renal/urinary system MP:0005367 10.06 ACE ALB BMPR2 EDN1 FBN1 MC3R
7 embryo MP:0005380 9.97 ACE BMPR2 EDN1 F2 F3 FBN1
8 immune system MP:0005387 9.93 ACE ALB BMPR2 CRP F2 F3
9 respiratory system MP:0005388 9.56 BMPR2 F2 F3 FBN1 GATA6 MYH6
10 mortality/aging MP:0010768 9.5 ACE ALB BMPR2 EDN1 F2 F3

Drugs & Therapeutics for Tricuspid Valve Disease

Drugs for Tricuspid Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Bupivacaine Approved, Investigational 2180-92-9, 38396-39-3 2474
Magnesium sulfate Approved, Investigational, Vet_approved 7487-88-9
Dexlansoprazole Approved, Investigational 138530-94-6 9578005
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3 3680
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 3003 5743
Acetaminophen Approved 103-90-2 1983
Lansoprazole Approved, Investigational 103577-45-3 3883
Ondansetron Approved, Withdrawn 99614-02-5 4595
Gabapentin Approved, Investigational 60142-96-3 3446
Milrinone Approved 78415-72-2 4197
11 Kava Approved, Investigational, Nutraceutical 9000-38-8
12 Analgesics
13 Antineoplastic Agents, Hormonal
14 Neurotransmitter Agents
15 Anti-Ulcer Agents
16 Antipyretics
17 Antipsychotic Agents
18 Hormones
19 Anti-Anxiety Agents
20 Antacids
21 Hormone Antagonists
22 Excitatory Amino Acid Antagonists
23 Psychotropic Drugs
24 Proton Pump Inhibitors
25 Antiemetics
26 Anesthetics, Local
27 Anticonvulsants
28 Opiate Alkaloids
29 glucocorticoids
30 Anesthetics
31 Anti-Inflammatory Agents
32 Analgesics, Non-Narcotic
33 Emetics
34 Gastrointestinal Agents
35 Dermatologic Agents
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Feasibility of Delivering Enhanced Recovery After Cardiac Surgery Unknown status NCT03859102 Oral Gabapentin pre-op;Oral Lansoprazole pre-op;Intravenous Paracetamol intra-operatively;Intravenous Dexamethasone intra-operatively;Intravenous Ondansetron intra-operatively;Infiltration of surgical wounds with local anaesthetic;Intravenous Magnesium intra-operatively;Post-operative Gabapentin analgesia;Post-operative oral Paracetamol analgesia;Post-operative Ondansetron anti-emesis
2 Assessment of the Effect of Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation in Patients Undergoing Open Heart Surgery Completed NCT03239262
3 Edwards EVOQUE Transcatheter Tricuspid Valve Replacement: Pivotal Clinical Investigation of Safety and Clinical Efficacy Using a Novel Device Recruiting NCT04482062 Optimal Medical Therapy
4 Quality of Life After Cardiac Surgery Recruiting NCT04231461
5 A Prospective, Multicenter, Randomized, Controlled Pivotal Trial to Evaluate the Safety and Effectiveness of Transcatheter Tricuspid Valve Repair With the Edwards PASCAL Transcatheter Valve Repair System and Optimal Medical Therapy (OMT) Compared to OMT Alone in Patients With Tricuspid Regurgitation Recruiting NCT04097145 Optimal Medical Therapy
6 CorMatrix Cor TRICUSPID ECM Valve Replacement Safety and Early Feasibility Recruiting NCT02397668
7 Clinical and Echocardiographic Characteristics and Prognosis of trIcuspid regurgiTation (EPIT): Prospective and Retrospective Follow-up of a Cohort of Patients With Moderate or Severe Tricuspid Regurgitation Recruiting NCT03546231
8 The Philips (VeriSight) Intracardiac Echocardiography (ICE) Registry Recruiting NCT04950192
9 Annuloplasty for the Treatment of Not-Severe Tricuspid Regurgitation in Patients Undergoing Surgery for Mitral Valve Disease: a Prospective, Spontaneous, Multicentre, Randomized Study Recruiting NCT02996552
10 Natural History of Melody Valve in the Mitral and Tricuspid Position Active, not recruiting NCT02505074
11 Single Centre, Prospective, Single Arm Open Label Series of a Transcatheter Tricuspid Valved Stent Graft System for the Reduction of Tricuspid Regurgitation and Improved Patient Reported Outcomes in Patients With Carcinoid Heart Disease Not yet recruiting NCT05064514
12 Single-Center, Prospective, Open-Label Study Standardizing a Prehabilitation Protocol to Optimize Patients Prior to Undergoing Tricuspid Intervention Terminated NCT04665583

Search NIH Clinical Center for Tricuspid Valve Disease

Genetic Tests for Tricuspid Valve Disease

Anatomical Context for Tricuspid Valve Disease

Organs/tissues related to Tricuspid Valve Disease:

FMA: Tricuspid Valve Between The Right Atrium
MalaCards : Heart, Small Intestine, Liver, Kidney, Lung, Spleen

Publications for Tricuspid Valve Disease

Articles related to Tricuspid Valve Disease:

(show top 50) (show all 356)
# Title Authors PMID Year
National Trends and Outcomes of Tricuspid Valve Surgery with Concomitant Mitral Valve Surgery: results from a ten-year analysis of the National Inpatient Sample Database. 62
36450330 2022
Surgical approach to combined mitral and tricuspid valve disease: good neighbourhood rules. 62
36380807 2022
Original technique for tricuspid valve replacement by mitral homograft: Step-by-step approach and initial results. 62
36378863 2022
A Computational Framework for Atrioventricular Valve Modeling Using Open-Source Software. 62
35510823 2022
Percutaneous Treatment Options for Complex Mitral and Tricuspid Valve Disease. 62
36223217 2022
Mitral and tricuspid valve disease: diagnosis and management. Consensus document of the Section on Valvular Heart Disease and the Cardiovascular Imaging, Clinical Cardiology, and Interventional Cardiology Associations of the Spanish Society of Cardiology. 62
35926720 2022
Double trouble: rheumatic systemic tricuspid valve disease in congenitally corrected transposition of the great arteries. 62
36043212 2022
Outcome of patients undergoing isolated tricuspid repair or replacement surgery. 62
35448903 2022
Tricuspid valve in congenital heart disease: multimodality imaging and electrophysiological considerations. 62
33944535 2022
Isolated tricuspid valve disease: transcatheter treatment 'for all'? 62
35575354 2022
Transcatheter interventions for severe tricuspid regurgitation: a literature review. 62
35975018 2022
Mechanistic Insights into Tricuspid Regurgitation Secondary to Pulmonary Arterial Hypertension. 62
35597628 2022
Cardiac valvular surgery and history of anorectic drug intake: A retrospective study of a large population of benfluorex-exposed patients. 62
35697655 2022
Application effect of thoracoscopic tricuspid valvuloplasty in geriatric patients with tricuspid valve disease. 62
35801058 2022
Isolated Tricuspid Valve Surgery: The Auckland Experience 2011-2019. 62
34711497 2022
Isolated Tricuspid Valve Replacement for Infective Endocarditis. 62
35465082 2022
Case Report of a 33-year-old with Ebstein malformation of tricuspid valve and hypertrophic cardiomyopathy. 62
34496998 2022
Multiple-valve Repair Facilitated by Aortic Ring Annuloplasty. 62
34102172 2022
Tricuspid valve disease prevalence and the impact of tricuspid valve surgery on cardiovascular events and hospital resource use in medicare beneficiaries. 62
34932999 2022
Predictors of safety and success in minimally invasive surgery for degenerative mitral disease. 62
34738105 2022
Transcatheter tricuspid valve interventions: Current status and future perspectives. 62
36187002 2022
Epidemiological Study of Tricuspid Regurgitation After Cardiac Transplantation. Does it Influence Survival? 62
35387398 2022
Human phenotype ontology annotation and cluster analysis for pulmonary atresia to unravel clinical outcomes. 62
35966552 2022
Prediction of mortality in isolated tricuspid surgery. 62
34674305 2022
Right heart failure and patient selection for isolated tricuspid valve surgery. 62
35123790 2021
Transcatheter treatment for tricuspid valve disease. 62
34796878 2021
Complicated postoperative course in isolated tricuspid valve surgery: Looking for predictors. 62
34131952 2021
Bitemporal hemianopsia secondary to ischemic chiasmopathy following mechanical thrombectomy. 62
34458646 2021
Transcatheter Tricuspid Valve-in-Valve Procedure-An Illustrative Case Report and Review. 62
34501452 2021
Assessment of the tricuspid valve using cardiovascular magnetic resonance. 62
34397458 2021
Commentary: Tricuspid valve disease at the time of surgical aortic valve replacement: Treat it or leave it? 62
32417067 2021
Transcatheter Interventions for Tricuspid Valve Disease: What to Do and Who to Do It On. 62
33493660 2021
Transcatheter tricuspid valve repair and replacement: a landscape review of current techniques and devices for the treatment of tricuspid valve regurgitation. 62
33834941 2021
Prevalence and Outcomes of Tricuspid Valve Disease in Patients Undergoing Mitral Valve Surgery (from the Nationwide Inpatient Sample Database). 62
33476551 2021
Mechanical Versus Bioprosthetic Valve Replacement in the Tricuspid Valve Position: A Systematic Review and Meta-Analysis. 62
33229238 2021
Minimally invasive tricuspid valve surgery. 62
33841984 2021
Multi-Modality Imaging for Interventions in Tricuspid Valve Disease. 62
33634175 2021
Atrioventricular Block after Tricuspid Valve Surgery. 62
33455981 2021
Healthcare utilization in clinically significant tricuspid regurgitation patients with and without heart failure. 62
33174767 2021
IMPULSE: the impact of gender on the presentation and management of aortic stenosis across Europe. 62
33419934 2021
Tricuspid Regurgitation in Left Ventricular Systolic Dysfunction: Marker or Target? 62
34262955 2021
Increased risk of valvular heart disease in patients with ankylosing spondylitis: a nationwide population-based longitudinal cohort study. 62
34211590 2021
[Surgical treatment of tricuspid valve disease due to permanent pacemaker lead]. 62
33142396 2020
Surgical Repair for Primary Tricuspid Valve Disease: Individualized Surgical Planning With 3-Dimensional Printing. 62
34317143 2020
Ebstein's Anomaly of the Tricuspid Valve: an Overview of Pathology and Management. 62
33037480 2020
Off-Pump Tricuspid Annuloplasty through a Direct Transatrial Approach: Early Results. 62
31683327 2020
Left-sided congenitally unguarded tricuspid valve with congenitally corrected transposition of the great arteries: A rare diagnosis confirmed by three-dimensional echocardiography. 62
32652546 2020
Tricuspid valve replacement: an appraisal of 45 years of experience. 62
32221593 2020
Emerging transcatheter therapies for tricuspid valve disease. 62
36003678 2020
Temporal Trends in Prevalence of Tricuspid Valve Disease in Hospitalized Patients in the United States. 62
32303339 2020

Variations for Tricuspid Valve Disease

Expression for Tricuspid Valve Disease

Search GEO for disease gene expression data for Tricuspid Valve Disease.

Pathways for Tricuspid Valve Disease

Pathways related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
12.15 NPPB NKX2-5 MYH7 BMPR2
3 11.59 TNNT2 TNNI3 NKX2-5
4 11.58 TNNT2 TNNI3 NKX2-5 ALB
Show member pathways
11.37 TNNT2 TNNI3 MYH6
6 11.1 NKX2-5 GATA6 BMPR2
7 10.98 TNNT2 TNNI3 NKX2-5 MYH6
8 10.27 NPPB NKX2-5 MYH7 BMPR2

GO Terms for Tricuspid Valve Disease

Cellular components related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.18 ACE ALB BMPR2 CRP EDN1 F2
2 cardiac myofibril GO:0097512 9.62 TNNT2 TNNI3
3 cardiac Troponin complex GO:1990584 9.56 TNNT2 TNNI3
4 sarcomere GO:0030017 9.56 TNNT2 TNNI3 MYH7 MYH6
5 myofibril GO:0030016 9.1 TNNT2 TNNI3 MYH7 MYH6

Biological processes related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 10.1 TNNT2 TNNI3 MYH7 MYH6
2 sarcomere organization GO:0045214 10.02 TNNT2 MYH7 MYH6
3 regulation of heart rate GO:0002027 10.01 MYH7 MYH6 MC3R
4 outflow tract septum morphogenesis GO:0003148 9.99 NKX2-5 GATA6 BMPR2
5 vasoconstriction GO:0042310 9.93 EDN1 CRP ACE
6 blood vessel diameter maintenance GO:0097746 9.92 ACE EDN1 NPPB
7 positive regulation of cardioblast differentiation GO:0051891 9.88 NKX2-5 GATA6
8 cardiac muscle hypertrophy in response to stress GO:0014898 9.88 MYH7 MYH6 GATA6
9 body fluid secretion GO:0007589 9.87 NPPB EDN1
10 atrioventricular node development GO:0003162 9.86 NKX2-5 GATA6
11 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.86 MYH6 MYH7 TNNI3 TNNT2
12 adult heart development GO:0007512 9.85 NKX2-5 MYH7 MYH6
13 striated muscle contraction GO:0006941 9.83 MYH6 MYH7 TNNI3
14 muscle filament sliding GO:0030049 9.8 TNNT2 MYH7 MYH6
15 heart contraction GO:0060047 9.7 TNNI3 NKX2-5 GATA6 ACE
16 cardiac muscle tissue development GO:0048738 9.65 NKX2-5 GATA6 BMPR2
17 cardiac muscle contraction GO:0060048 9.65 TNNT2 TNNI3 NKX2-5 MYH7 MYH6
18 regulation of blood pressure GO:0008217 9.36 REN NPPB MYH6 MC3R EDN1 ACE

Molecular functions related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microfilament motor activity GO:0000146 9.35 TNNT2 MYH7 MYH6
2 troponin C binding GO:0030172 8.92 TNNT2 TNNI3

Sources for Tricuspid Valve Disease

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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