MCID: TRC087
MIFTS: 41

Tricuspid Valve Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Disease

MalaCards integrated aliases for Tricuspid Valve Disease:

Name: Tricuspid Valve Disease 12 15
Rheumatic Tricuspid Valve Disease 12 73
Rheumatic Disease of Tricuspid Valve 12
Abnormality of the Tricuspid Valve 29
Rh. Tricuspid Valve Disease 12
Disease of Tricuspid Valve 12
Tricuspid Valve Disorder 73
Tricuspid Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050826
ICD10 33 I07 I07.9 I39.2
ICD9CM 35 397.0

Summaries for Tricuspid Valve Disease

MalaCards based summary : Tricuspid Valve Disease, also known as rheumatic tricuspid valve disease, is related to tricuspid atresia and tricuspid valve stenosis. An important gene associated with Tricuspid Valve Disease is GATA6 (GATA Binding Protein 6), and among its related pathways/superpathways are Heart Development and Cardiomyocyte Differentiation through BMP Receptors. The drugs Cabergoline and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, and related phenotypes are cardiovascular system and embryo

Related Diseases for Tricuspid Valve Disease

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 tricuspid atresia 30.5 CRELD1 GDF1 HEY2 NKX2-5 NKX2-6
2 tricuspid valve stenosis 30.2 ARSE CRELD1 FBN1 HEY2 NKX2-6
3 ebstein anomaly 30.1 CRELD1 GDF1 MYH7 NKX2-5 NKX2-6 NPPB
4 transposition of the great arteries 29.7 GDF1 NKX2-5 ZIC3
5 tricuspid valve insufficiency 28.3 ACVRL1 ARSE CRELD1 FBN1 MC3R NPPB
6 atrial septal defect 9 11.1
7 partial atrioventricular canal 10.7 CRELD1 GATA6
8 complete atrioventricular canal-ventricle hypoplasia syndrome 10.7 CRELD1 GATA6
9 pulmonary valve disease 10.4 CRELD1 GATA6 NKX2-6
10 total anomalous pulmonary venous return 1 10.3 CRELD1 GDF1 NKX2-6
11 atrial septal defect 4 10.3 GATA6 NKX2-5
12 dextro-looped transposition of the great arteries 10.3 GDF1 NKX2-6 ZIC3
13 pulmonary valve insufficiency 10.1 NKX2-6 NPPB
14 diaphragmatic eventration 10.1 FBN1 NKX2-6
15 familial atrial fibrillation 10.1 GATA6 NKX2-5 NKX2-6
16 toxic myocarditis 10.0 NPPB ZIC3
17 cardiac tamponade 10.0 ACVRL1 NPPB
18 conotruncal heart malformations 9.9 GATA6 GDF1 NKX2-5 NKX2-6
19 mitral valve stenosis 9.9 ACVRL1 CRELD1 NPPB
20 aortic valve insufficiency 9.8 FBN1 NKX2-6 NPPB
21 mitral valve insufficiency 9.8 CRELD1 FBN1 NPPB
22 hepatitis 9.8
23 infective endocarditis 9.8
24 endocarditis 9.8
25 antiphospholipid syndrome 9.8
26 carcinoid syndrome 9.8
27 congenitally corrected transposition of the great arteries 9.8
28 double discordia 9.8
29 aortic valve disease 1 9.8 FBN1 NKX2-6 NPPB
30 acute cor pulmonale 9.7 NPPB PDZK1IP1
31 hypoplastic left heart syndrome 9.6 NKX2-5 NKX2-6 NPPB
32 char syndrome 9.6 FBN1 NKX2-5
33 acute pulmonary heart disease 9.6 NPPB PDZK1IP1
34 atrioventricular septal defect 9.6 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6
35 aortic valve disease 2 9.4 FBN1 MYH7 NKX2-6 NPPB
36 patent ductus arteriosus 1 9.4 CRELD1 GATA6 GDF1 NKX2-6 NPPB
37 heart septal defect 9.2 ACVRL1 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6
38 atrial heart septal defect 9.2 ACVRL1 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6
39 double outlet right ventricle 9.2 CRELD1 GATA6 GDF1 NKX2-5 NKX2-6 ZIC3
40 ventricular septal defect 8.7 GATA6 GDF1 MYH7 NKX2-5 NKX2-6 NPPB
41 tetralogy of fallot 7.8 CRELD1 FBN1 GATA6 GDF1 HEY2 NKX2-5
42 heart disease 7.5 CRELD1 FBN1 GATA6 GDF1 MYH7 NKX2-5

Comorbidity relations with Tricuspid Valve Disease via Phenotypic Disease Network (PDN): (show all 40)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Aortic Valve Disease 1
Aortic Valve Insufficiency Bronchitis
Cardiac Arrest Cardiogenic Shock
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Intermediate Coronary Syndrome
Intracranial Embolism Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Mitral Valve Disease Mitral Valve Stenosis
Nutmeg Liver Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Pulmonary Hypertension, Primary, 1 Pulmonary Valve Disease
Respiratory Failure Rheumatic Heart Disease
Rheumatic Pulmonary Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Tricuspid Valve Disease:



Diseases related to Tricuspid Valve Disease

Symptoms & Phenotypes for Tricuspid Valve Disease

MGI Mouse Phenotypes related to Tricuspid Valve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 HEY2 ACVRL1 MYH7 NKX2-5 CRELD1 FBN1
2 embryo MP:0005380 9.91 HEY2 ACVRL1 NKX2-5 CRELD1 FBN1 NKX2-6
3 craniofacial MP:0005382 9.87 GDF1 HEY2 ACVRL1 CRELD1 NKX2-5 FBN1
4 growth/size/body region MP:0005378 9.81 GDF1 HEY2 MC3R ACVRL1 NKX2-5 FBN1
5 muscle MP:0005369 9.43 HEY2 MYH7 ACVRL1 NKX2-5 FBN1 GATA6
6 respiratory system MP:0005388 9.23 HEY2 ACVRL1 NKX2-5 FBN1 NKX2-6 GATA6

Drugs & Therapeutics for Tricuspid Valve Disease

Drugs for Tricuspid Valve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cabergoline Approved 81409-90-7 54746
2
Dopamine Approved 51-61-6, 62-31-7 681
3
Levodopa Approved 59-92-7 6047
4 Autonomic Agents
5 Dopamine Agents
6 Dopamine agonists
7 Neurotransmitter Agents
8 Peripheral Nervous System Agents
9 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cardiovascular Toxicity Induced by Antitumoral Drugs: Risk Assessment and Early Diagnosis. CARDIOTOX Registry Unknown status NCT02039622
2 Left Atrial Cryoablation Enhanced by Ganglionated Plexi Ablation in the Treatment of Atrial Fibrillation Completed NCT03239262 Not Applicable
3 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
4 Characteristics and Prognosis of Moderate or Severe Tricuspid Regurgitation Recruiting NCT03546231
5 Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM) Recruiting NCT02996552 Not Applicable
6 International Multisite Transcatheter Tricuspid Valve Therapies Registry Recruiting NCT03416166
7 Pathogenetic Basis of Aortopathy and Aortic Valve Disease Recruiting NCT03440697
8 CorMatrix ECM Tricuspid Valve Replacement Active, not recruiting NCT02397668 Not Applicable
9 A Study to Identify Differences in Gene Expression in Patients With Bicuspid and Tricuspid Valve Disease Active, not recruiting NCT01194362
10 Natural History of Melody Valve in the Mitral and Tricuspid Position Active, not recruiting NCT02505074

Search NIH Clinical Center for Tricuspid Valve Disease

Genetic Tests for Tricuspid Valve Disease

Genetic tests related to Tricuspid Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Tricuspid Valve 29

Anatomical Context for Tricuspid Valve Disease

MalaCards organs/tissues related to Tricuspid Valve Disease:

41
Heart

Publications for Tricuspid Valve Disease

Articles related to Tricuspid Valve Disease:

(show all 41)
# Title Authors Year
1
Response to: 'Congenital tricuspid valve disease can masquerade as primary idiopathic TR' by Rajpal. ( 29478037 )
2018
2
Periprocedural and perioperatory management of patients with tricuspid valve disease. ( 29642696 )
2018
3
Congenital tricuspid valve disease can masquerade as primary idiopathic tricuspid regurgitation. ( 29748394 )
2018
4
The other side of the coin in primary tricuspid valve disease: The incremental value of 3D echocardiography. ( 29853700 )
2018
5
Cardiac Computed Tomography and Magnetic Resonance Imaging in the Evaluation of Mitral and Tricuspid Valve Disease: Implications for Transcatheter Interventions. ( 28292860 )
2017
6
Percutaneous Treatment of the Tricuspid Valve Disease: New Hope for the "Forgotten" Valve. ( 28645836 )
2017
7
Single-site ventricular pacing via the coronary sinus in patients with tricuspid valve disease. ( 28339945 )
2017
8
Tricuspid valve disease. ( 28706876 )
2017
9
Transcatheter Tricuspid Valve-in-Valve Intervention for Degenerative Bioprosthetic Tricuspid Valve Disease. ( 28843367 )
2017
10
Right Atrial Dysfunction in the Fetus with Severely Regurgitant Tricuspid Valve Disease: A Potential Source of Cardiovascular Compromise. ( 28410946 )
2017
11
How to Treat Tricuspid Valve Disease: What's New on the Horizon? ( 28290005 )
2017
12
Multi-site multi-polar left ventricular pacing through persistent left superior vena cava in tricuspid valve disease. ( 29192594 )
2017
13
Non-functional tricuspid valve disease. ( 28706863 )
2017
14
Radial Multi-Site, Longitudinal Multi-Polar Epicardial Left Ventricular Pacing In Tricuspid Valve Disease. ( 27698523 )
2016
15
Contemporary Outcomes and Factors Associated With Mortality After a Fetal or Neonatal Diagnosis of Ebstein Anomaly and Tricuspid Valve Disease. ( 27476984 )
2016
16
Diagnosis and treatment of tricuspid valve disease: current and future perspectives. ( 27048553 )
2016
17
Spectral Doppler of the Hepatic Veins in Tricuspid Valve Disease. ( 25250676 )
2014
18
Echo diagnosis of rheumatic tricuspid valve disease. ( 24495168 )
2014
19
Massive cardiac atriomegaly in tricuspid valve disease. ( 24269360 )
2014
20
Surgical treatment of organic and functional tricuspid valve disease. ( 24774120 )
2013
21
Evidence-based surgical management of acquired tricuspid valve disease. ( 23399976 )
2013
22
Incidental aortic valve calcification on CT scans: significance for bicuspid and tricuspid valve disease. ( 22104287 )
2012
23
Carcinoid tricuspid valve disease: incremental value of three-dimensional echocardiography. ( 22113204 )
2012
24
Repair of rheumatic tricuspid valve disease: predictors of very long-term mortality and reoperation. ( 20667339 )
2010
25
Coronary sinus dilatation. A simple additional echocardiographic indicator of severe rheumatic mitral and tricuspid valve disease. ( 20174730 )
2010
26
Rheumatic tricuspid valve disease: an evidence-based systematic overview. ( 20583402 )
2010
27
Tricuspid valve disease: pathophysiology and optimal management. ( 19410682 )
2009
28
Valve repair with autologous pericardium for organic lesions in rheumatic tricuspid valve disease. ( 19231380 )
2009
29
Tricuspid valve disease. ( 18222317 )
2008
30
Surgery for rheumatic tricuspid valve disease: a 30-year experience. ( 18692660 )
2008
31
Left ventricular myocardial performance in the fetus with severe tricuspid valve disease and tricuspid insufficiency. ( 15731988 )
2005
32
Tricuspid valve disease: tricuspid valve complex perspective. ( 11979238 )
2002
33
Ventricular pacing in the presence of tricuspid valve disease. ( 11915977 )
2002
34
Congenital Heart Surgery Nomenclature and Database Project: Ebstein's anomaly and tricuspid valve disease. ( 10798422 )
2000
35
Juvenile tricuspid stenosis and rheumatic tricuspid valve disease: an echocardiographic study. ( 10636636 )
1999
36
Isolated tricuspid valve disease in antiphospholipid syndrome. ( 10483018 )
1999
37
Progressive tricuspid valve disease in patients with congenitally corrected transposition of the great arteries. ( 9737520 )
1998
38
Infective endocarditis complicating tricuspid valve disease in the carcinoid syndrome. ( 3128367 )
1988
39
Rheumatic tricuspid valve disease: two-dimensional echocardiographic, hemodynamic, and angiographic correlations. ( 6823865 )
1983
40
Surgery for rheumatic tricuspid valve disease in children. ( 939773 )
1976
41
The anatomical appearance in rheumatic tricuspid valve disease. ( 13413007 )
1957

Variations for Tricuspid Valve Disease

Expression for Tricuspid Valve Disease

Search GEO for disease gene expression data for Tricuspid Valve Disease.

Pathways for Tricuspid Valve Disease

Pathways related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 GATA6 HEY2 NKX2-5
2 10.14 MYH7 NKX2-5 NPPB

GO Terms for Tricuspid Valve Disease

Biological processes related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 BMP signaling pathway GO:0030509 9.65 ACVRL1 GDF1 NKX2-5
2 positive regulation of cardiac muscle cell proliferation GO:0060045 9.63 GATA6 HEY2
3 cellular response to BMP stimulus GO:0071773 9.62 ACVRL1 GATA6
4 regulation of heart rate GO:0002027 9.62 MC3R MYH7
5 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.61 HEY2 NKX2-5
6 ventricular septum morphogenesis GO:0060412 9.61 HEY2 NKX2-5
7 positive regulation of BMP signaling pathway GO:0030513 9.6 ACVRL1 GATA6
8 cardiac muscle cell differentiation GO:0055007 9.59 GATA6 NKX2-5
9 outflow tract septum morphogenesis GO:0003148 9.58 GATA6 NKX2-5
10 cardiac muscle tissue development GO:0048738 9.58 GATA6 NKX2-5
11 embryonic heart tube development GO:0035050 9.57 NKX2-5 NKX2-6
12 pharyngeal system development GO:0060037 9.56 NKX2-5 NKX2-6
13 ventricular trabecula myocardium morphogenesis GO:0003222 9.55 HEY2 NKX2-5
14 heart development GO:0007507 9.55 FBN1 GATA6 HEY2 NKX2-5 NKX2-6
15 heart trabecula formation GO:0060347 9.54 HEY2 NKX2-5
16 regulation of blood pressure GO:0008217 9.54 ACVRL1 MC3R NPPB
17 adult heart development GO:0007512 9.52 MYH7 NKX2-5
18 smooth muscle cell differentiation GO:0051145 9.51 GATA6 HEY2
19 atrial septum morphogenesis GO:0060413 9.49 HEY2 NKX2-5
20 cardiac ventricle morphogenesis GO:0003208 9.46 HEY2 NKX2-5
21 artery development GO:0060840 9.43 ACVRL1 HEY2
22 dorsal aorta morphogenesis GO:0035912 9.4 ACVRL1 HEY2
23 positive regulation of cardioblast differentiation GO:0051891 9.32 GATA6 NKX2-5
24 atrial cardiac muscle cell development GO:0055014 9.26 NKX2-5 NKX2-6
25 cardiac muscle hypertrophy in response to stress GO:0014898 9.13 GATA6 HEY2 MYH7
26 ventricular cardiac muscle cell development GO:0055015 8.8 HEY2 NKX2-5 NKX2-6
27 positive regulation of transcription by RNA polymerase II GO:0045944 10.03 ACVRL1 GATA6 HEY2 NKX2-5 ZIC3

Molecular functions related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.02 GATA6 HEY2 NKX2-5 NKX2-6 ZIC3

Sources for Tricuspid Valve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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