Tricuspid Valve Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Disease

MalaCards integrated aliases for Tricuspid Valve Disease:

Name: Tricuspid Valve Disease 12 15 17
Rheumatic Tricuspid Valve Disease 12 71
Rheumatic Disease of Tricuspid Valve 12
Abnormality of the Tricuspid Valve 29
Rh. Tricuspid Valve Disease 12
Disease of Tricuspid Valve 12
Tricuspid Valve Disorder 71
Tricuspid Disease 12


External Ids:

Disease Ontology 12 DOID:0050826
ICD9CM 34 397.0
SNOMED-CT 67 49699002
ICD10 32 I07 I07.9 I39.2
UMLS 71 C0264776 C0264882

Summaries for Tricuspid Valve Disease

Disease Ontology : 12 A heart valve disease that is characterized by valvular insufficiency or valvular stenosis, located in tricuspid valve between the right atrium and right ventricle.

MalaCards based summary : Tricuspid Valve Disease, also known as rheumatic tricuspid valve disease, is related to tricuspid atresia and ebstein anomaly. An important gene associated with Tricuspid Valve Disease is GATA6 (GATA Binding Protein 6), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Cardiomyocyte Differentiation through BMP Receptors. Affiliated tissues include tricuspid valve between the right atrium, heart and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 The tricuspid valve, or right atrioventricular valve, is on the right dorsal side of the mammalian... more...

Related Diseases for Tricuspid Valve Disease

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
# Related Disease Score Top Affiliating Genes
1 tricuspid atresia 33.2 ZIC3 NKX2-5 GATA6
2 ebstein anomaly 32.8 ZIC3 NPPB NKX2-5 MYH7 MYH6
3 endocarditis 31.0 F2 CRP ALB
4 dextro-looped transposition of the great arteries 30.6 ZIC3 NPPB NKX2-5
5 rheumatic fever 30.5 NPPB ALB ACE
6 tricuspid valve insufficiency 30.4 ZIC3 WBP2NL PDZK1IP1 PDE5A NPPB MC3R
7 ventricular septal defect 30.2 ZIC3 NPPB NKX2-5 MYH7 GATA6
8 esophageal varix 30.2 F3 F2 ALB
9 atrioventricular block 30.1 NPPB NKX2-5 MYH7 CA5B ACE
10 antiphospholipid syndrome 30.1 F3 F2 CRP
11 thrombophlebitis 30.1 F3 F2 CRP ALB
12 aortic valve disease 1 29.9 NKX2-5 MYH6 GATA6 FBN1 EDN1 ACE
13 mitral valve disease 29.8 PDZK1IP1 NPPB FBN1 F3 F2 CRP
14 heart septal defect 29.8 ZIC3 NKX2-5 MYH6 GATA6 F2 CA5B
15 portal hypertension 29.6 F3 F2 EDN1 ALB ACE
16 pulmonary hypertension 29.6 PDE5A NPPB F3 F2 EDN1 CRP
17 mitral valve stenosis 29.5 WBP2NL PDZK1IP1 NPPB F3 F2 CRP
18 aortic valve insufficiency 29.3 ZIC3 PDZK1IP1 NPPB FBN1 CRP CA5B
19 pulmonary embolism 29.2 PDE5A NPPB F3 F2 CRP ALB
20 pulmonary valve insufficiency 29.1 WBP2NL PDZK1IP1 PDE5A NPPB EDN1 CRP
21 heart valve disease 29.0 PDZK1IP1 NPPB NKX2-5 MYH6 FBN1 F2
22 mitral valve insufficiency 28.8 ZIC3 PDZK1IP1 NPPB MYH6 FBN1 F2
23 tricuspid valve stenosis 11.9
24 atrial septal defect 9 11.3
25 mediastinum teratoma 10.6 CRP ACE
26 acute dacryoadenitis 10.6 CRP ACE
27 cardiogenic shock 10.6 NPPB CRP
28 arteritic anterior ischemic optic neuropathy 10.6 F2 ACE
29 toxic myocarditis 10.6 NPPB ACE
30 posterior scleritis 10.6 CRP ACE
31 chronic duodenal ileus 10.6 CRP ALB
32 tolosa-hunt syndrome 10.6 CRP ACE
33 cardiac tuberculosis 10.5 NPPB CRP ACE
34 polycystic kidney disease 4 10.5 NPPB ALB
35 anterolateral myocardial infarction 10.5 NPPB ACE
36 vasculogenic impotence 10.5 PDE5A ACE
37 multiple cranial nerve palsy 10.5 CRP ACE
38 orbital osteomyelitis 10.5 F2 CRP
39 heart, malformation of 10.5 NKX2-5 MYH6
40 small intestine diverticulitis 10.5 F2 CRP
41 central sleep apnea 10.5 NPPB CRP ACE
42 granulomatous angiitis 10.5 CRP ACE
43 mobitz type ii atrioventricular block 10.5 CA5B ACE
44 hepatoportal sclerosis 10.5 F2 ACE
45 glomerular disease 10.5 ALB ACE
46 orthostatic proteinuria 10.5 ALB ACE
47 neuroretinitis 10.5 CRP ACE
48 chronic thromboembolic pulmonary hypertension 10.5 NPPB EDN1 CRP
49 idiopathic edema 10.5 NPPB EDN1 ACE
50 tuberculous peritonitis 10.5 CRP ALB

Comorbidity relations with Tricuspid Valve Disease via Phenotypic Disease Network (PDN): (show all 37)

Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Aortic Valve Disease 1
Aortic Valve Insufficiency Bronchitis
Cardiac Arrest Cardiogenic Shock
Chronic Pulmonary Heart Disease Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Intermediate Coronary Syndrome
Intracranial Embolism Iron Deficiency Anemia
Kidney Disease Mitral Valve Disease
Mitral Valve Stenosis Nutmeg Liver
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Pulmonary Hypertension, Primary, 1
Pulmonary Valve Disease Respiratory Failure
Rheumatic Heart Disease Rheumatic Pulmonary Valve Disease
Right Bundle Branch Block Sinoatrial Node Disease
Third-Degree Atrioventricular Block Transient Cerebral Ischemia
Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Tricuspid Valve Disease:

Diseases related to Tricuspid Valve Disease

Symptoms & Phenotypes for Tricuspid Valve Disease

MGI Mouse Phenotypes related to Tricuspid Valve Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ACE ALB CRP EDN1 F2 F3
2 homeostasis/metabolism MP:0005376 9.97 ACE ALB CA5B CRP EDN1 F2
3 muscle MP:0005369 9.56 ALB EDN1 F3 FBN1 GATA6 MYH6
4 normal MP:0002873 9.28 ALB EDN1 F2 F3 GATA6 MYH7

Drugs & Therapeutics for Tricuspid Valve Disease

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 Genes Causing Congenital Ebstein's Anomaly Completed NCT00497705
2 CorMatrix Cor TRICUSPID ECM Valve Replacement Safety and Early Feasibility Recruiting NCT02397668
3 International Multisite Transcatheter Tricuspid Valve Therapies Registry Recruiting NCT03416166
4 Clinical and Echocardiographic Characteristics and Prognosis of trIcuspid regurgiTation (EPIT): Prospective and Retrospective Follow-up of a Cohort of Patients With Moderate or Severe Tricuspid Regurgitation Recruiting NCT03546231
5 Annuloplasty for the Treatment of Not-Severe Tricuspid Regurgitation in Patients Undergoing Surgery for Mitral Valve Disease: a Prospective, Spontaneous, Multicentre, Randomized Study Recruiting NCT02996552
6 NHLBI Structural Heart and Valve Network Prospective Registry Not yet recruiting NCT03928639
7 Study of New Predictors and Short Term Outcomes of Paravalvular Leakage Post Transcatheter Aortic Valve Implanation Not yet recruiting NCT03424902

Search NIH Clinical Center for Tricuspid Valve Disease

Genetic Tests for Tricuspid Valve Disease

Genetic tests related to Tricuspid Valve Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Tricuspid Valve 29

Anatomical Context for Tricuspid Valve Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Tricuspid Valve Disease:

Tricuspid Valve Between The Right Atrium

MalaCards organs/tissues related to Tricuspid Valve Disease:

Heart, Lung, Small Intestine, Kidney

Publications for Tricuspid Valve Disease

Articles related to Tricuspid Valve Disease:

(show top 50) (show all 252)
# Title Authors PMID Year
Temporal Trends in Prevalence of Tricuspid Valve Disease in Hospitalized Patients in the United States. 61
32303339 2020
Tricuspid valve replacement: an appraisal of 45 years of experience. 61
32221593 2020
Three-dimensional echocardiography for the assessment of the tricuspid valve. 61
32315483 2020
Transcatheter Tricuspid and Pulmonary Valve Repair and Replacement. 61
32379893 2020
Commentary: Tricuspid valve disease at the time of surgical aortic valve replacement: Treat it or leave it? 61
32417067 2020
Optimizing Cardiac CT Protocols for Comprehensive Acquisition Prior to Percutaneous MV and TV Repair/Replacement. 61
31422136 2020
Mitral and Tricuspid Transcatheter Interventions Current Indications and Future Directions. 61
32500083 2020
Isolated surgical tricuspid repair versus replacement: meta-analysis of 15 069 patients. 61
32206317 2020
Carcinoid Tricuspid Valve Disease: Applications of Three Dimensional Transesophageal Echocardiography. 61
31766860 2019
Left ventricular pacing in patients with preexisting tricuspid valve disease. 61
31844475 2019
Off-Pump Tricuspid Annuloplasty through a Direct Transatrial Approach: Early Results. 61
31683327 2019
Impact of Tricuspid Regurgitation in Patients With Heart Failure and Mitral Valve Disease from a Nationwide Cohort Study. 61
31331634 2019
Tricuspid valve disease: diagnosis, prognosis and management of a rapidly evolving field. 61
30988448 2019
Etiology of tricuspid valve disease is a predictor of bradyarrhythmia after tricuspid valve surgery. 61
30938919 2019
Current status and future perspective of structural heart disease intervention. 61
30955999 2019
Transcatheter Tricuspid Valve Interventions: Current Approaches and Future Perspectives. 61
31037717 2019
Tricuspid Valve Imaging and Intervention in Pediatric and Adult Patients With Congenital Heart Disease. 61
30947906 2019
Transcatheter heart valve interventions: where are we? Where are we going? 61
30608523 2019
Tricuspid Valve Disease: The "Forgotten Valve". 61
31238310 2019
Periprocedural and perioperatory management of patients with tricuspid valve disease. 61
29642696 2018
Percutaneous tricuspid valve replacement: orthotopic and heterotopic valves. 61
29589668 2018
Tricuspid valve surgery: repair and replacement. 61
29642693 2018
Response to: 'Congenital tricuspid valve disease can masquerade as primary idiopathic TR' by Rajpal. 61
29478037 2018
Contemporary management and outcomes in congenitally corrected transposition of the great arteries. 61
29326110 2018
Preoperative Right-Sided Cardiac Congestion Is Associated with Gastrointestinal Bleeding in Patients with Continuous-Flow Left Ventricular Assist Devices. 61
29417325 2018
Congenital tricuspid valve disease can masquerade as primary idiopathic tricuspid regurgitation. 61
29748394 2018
The other side of the coin in primary tricuspid valve disease: The incremental value of 3D echocardiography. 61
29853700 2018
Sutureless aortic valve replacement with concomitant valvular surgery. 61
29551538 2018
Transcatheter Tricuspid Valve-in-Valve Intervention for Degenerative Bioprosthetic Tricuspid Valve Disease. 61
28843367 2018
Single-site ventricular pacing via the coronary sinus in patients with tricuspid valve disease. 61
28339945 2018
Transcatheter Treatment of Tricuspid Valve Disease: An Unmet Need? The Surgical Point of View. 61
30083537 2018
Surgical Techniques for Tricuspid Valve Disease. 61
30234129 2018
Results and factors associated with adverse outcome after tricuspid valve replacement. 61
29589379 2018
Periareolar Access for Minimally Invasive Cardiac Surgery: The Brazilian Technique. 61
29432360 2018
The FORMA Repair System. 61
29157523 2018
Pattern and Extent of Tricuspid Valve Involvement in Chronic Rheumatic Heart Disease. 61
29459602 2018
Perioperative predictors of permanent pacing and long-term dependence following tricuspid valve surgery: a multicentre analysis. 61
28073887 2017
Percutaneous Treatment of the Tricuspid Valve Disease: New Hope for the "Forgotten" Valve. 61
28645836 2017
Multi-site multi-polar left ventricular pacing through persistent left superior vena cava in tricuspid valve disease. 61
29192594 2017
The big parade: emerging percutaneous mitral and tricuspid valve devices. 61
28942386 2017
Tricuspid valve replacement with mechanical prostheses: Short and long-term outcomes. 61
28795446 2017
Transforming Growth Factor Beta-2 Mutations in Barlow's Disease and Aortic Dilatation. 61
28633253 2017
Evaluation of Pericardial Effusion in Dogs and Successful Treatment Using a Hemodialysis Fistula Needle: A Retrospective Study. 61
28992908 2017
Right Atrial Dysfunction in the Fetus with Severely Regurgitant Tricuspid Valve Disease: A Potential Source of Cardiovascular Compromise. 61
28410946 2017
Non-functional tricuspid valve disease. 61
28706863 2017
Tricuspid valve disease. 61
28706876 2017
Cardiac Computed Tomography and Magnetic Resonance Imaging in the Evaluation of Mitral and Tricuspid Valve Disease: Implications for Transcatheter Interventions. 61
28292860 2017
How to Treat Tricuspid Valve Disease: What's New on the Horizon? 61
28290005 2017
Is Transcatheter Tricuspid Valve-In-Valve Implantation Feasible in the Presence of Right Atrial Thrombus? 61
28820553 2017
Innovations in tricuspid valve intervention. 61
28067714 2017

Variations for Tricuspid Valve Disease

Expression for Tricuspid Valve Disease

Search GEO for disease gene expression data for Tricuspid Valve Disease.

Pathways for Tricuspid Valve Disease

Pathways related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.53 MYH7 MYH6 EDN1 ACE
2 10.14 NPPB NKX2-5 MYH7

GO Terms for Tricuspid Valve Disease

Cellular components related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 NPPB FBN1 F3 F2 EDN1 CRP
2 extracellular space GO:0005615 9.28 NPPB FBN1 F3 F2 EDN1 CRP

Biological processes related to Tricuspid Valve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.73 GATA6 FBN1 F2 ALB
2 cardiac muscle contraction GO:0060048 9.5 NKX2-5 MYH7 MYH6
3 positive regulation of renal sodium excretion GO:0035815 9.48 NPPB EDN1
4 positive regulation of urine volume GO:0035810 9.46 NPPB EDN1
5 regulation of heart rate GO:0002027 9.43 MYH7 MYH6 MC3R
6 body fluid secretion GO:0007589 9.4 NPPB EDN1
7 positive regulation of cardioblast differentiation GO:0051891 9.37 NKX2-5 GATA6
8 cardiac muscle hypertrophy in response to stress GO:0014898 9.33 MYH7 MYH6 GATA6
9 adult heart development GO:0007512 9.13 NKX2-5 MYH7 MYH6
10 regulation of blood pressure GO:0008217 9.02 NPPB MYH6 MC3R EDN1 ACE

Sources for Tricuspid Valve Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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