Tricuspid Valve Insufficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TRC022 MIFTS: 37	Tricuspid Valve Insufficiency Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Drugs Download Expand all tables

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Aliases & Classifications for Tricuspid Valve Insufficiency

MalaCards integrated aliases for Tricuspid Valve Insufficiency:

Name: Tricuspid Valve Insufficiency ¹² ⁴⁴ ¹⁵ ⁷³

Tricuspid Regurgitation ¹² ²⁹ ⁵⁵ ⁶

Tricuspid Valve Regurgitation ¹²

Tricuspid Incompetence ¹²

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4080

MeSH ⁴⁴ D014262

NCIt ⁵⁰ C50842 C50843

SNOMED-CT ⁶⁸ 111287006 155347006 251009000 more

UMLS ⁷³ C0040961

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Summaries for Tricuspid Valve Insufficiency

Disease Ontology : ¹² A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.

MalaCards based summary : Tricuspid Valve Insufficiency, also known as tricuspid regurgitation, is related to mitral valve disease and pulmonary valve disease. An important gene associated with Tricuspid Valve Insufficiency is PTPN11 (Protein Tyrosine Phosphatase, Non-Receptor Type 11). The drugs Rivaroxaban and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are craniofacial and embryo

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Related Diseases for Tricuspid Valve Insufficiency

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)

#	Related Disease	Score	Top Affiliating Genes
1	mitral valve disease	29.5	CRELD1 FBN1
2	pulmonary valve disease	10.6	CRELD1 PTPN11
3	toxic myocarditis	10.6	NPPB ZIC3
4	cardiac tamponade	10.6	ACVRL1 NPPB
5	ebstein anomaly	10.5	CRELD1 NPPB
6	pulmonic stenosis	10.4	PTPN11 ZIC3
7	patent ductus arteriosus 1	10.3	CRELD1 NPPB PTPN11
8	mitral valve stenosis	10.3	ACVRL1 CRELD1 NPPB
9	heart septal defect	10.3	ACVRL1 CRELD1
10	constrictive pericarditis	10.2	ALB NPPB
11	aortic valve insufficiency	10.2	FBN1 NPPB
12	chylothorax, congenital	10.2	ALB PTPN11
13	syndrome of inappropriate antidiuretic hormone	10.2	ALB NPPB
14	noma	10.1	ALB PTPN11
15	renal hypertension	10.1	ALB NPPB
16	mitral valve insufficiency	10.0	CRELD1 FBN1 NPPB
17	arteries, anomalies of	9.9	ACVRL1 ALB NPPB
18	endocardial fibroelastosis	9.9
19	hypoplastic left heart syndrome 1	9.9
20	myocardial infarction	9.9
21	infantile liver failure syndrome 1	9.9
22	pulmonary hypertension	9.9
23	acute liver failure	9.9
24	hypoplastic left heart syndrome	9.9
25	protein-losing enteropathy	9.9
26	atrial heart septal defect	9.9
27	inferior myocardial infarction	9.9
28	pulmonary valve stenosis	9.9
29	situs inversus	9.9
30	pulmonary atresia with intact ventricular septum	9.8
31	hemopericardium	9.8
32	tricuspid valve prolapse	9.8
33	congenitally corrected transposition of the great arteries	9.8
34	double discordia	9.8
35	transposition of the great arteries	9.8
36	hydronephrosis	9.8	ALB ZIC3
37	tetralogy of fallot	9.7	CRELD1 FBN1 NPPB PTPN11
38	aortic valve disease 1	9.6	FBN1 NPPB
39	tricuspid valve stenosis	9.4	ARSE CA6 CRELD1 FBN1
40	heart disease	8.6	ALB CRELD1 FBN1 NPPB PTPN11 ZIC3
41	tricuspid valve disease	8.5	ACVRL1 ARSE CRELD1 FBN1 MC3R NPPB

Graphical network of the top 20 diseases related to Tricuspid Valve Insufficiency:

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Symptoms & Phenotypes for Tricuspid Valve Insufficiency

MGI Mouse Phenotypes related to Tricuspid Valve Insufficiency:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.55	ACVRL1 CRELD1 FBN1 PTPN11 ZIC3
2	embryo	MP:0005380	9.43	FBN1 PTPN11 SMG6 ZIC3 ACVRL1 CRELD1
3	normal	MP:0002873	9.1	ACVRL1 ALB PAPPA PTPN11 SMG6 ZIC3

Sources

Drugs & Therapeutics for Tricuspid Valve Insufficiency

Drugs for Tricuspid Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Rivaroxaban

Approved

Phase 4

366789-02-8

Warfarin

Approved

Phase 4

81-81-2

6691 54678486

Amiodarone

Approved, Investigational

Phase 4

1951-25-3

2157

Propafenone

Approved

Phase 4

54063-53-5

4932

Sotalol

Approved

Phase 4

959-24-0, 3930-20-9

5253

Tolvaptan

Approved

Phase 4

150683-30-0

216237

Ranolazine

Approved, Investigational

Phase 4

142387-99-3, 95635-55-5

56959

Serine

Approved, Nutraceutical

Phase 4

56-45-1

5951

Citric Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 2,Not Applicable

77-92-9

311

Kava

Approved, Investigational, Nutraceutical

Phase 4,Not Applicable

9000-38-8

Anticoagulants

Phase 4

Antithrombin III

Phase 4

Antithrombins

Phase 4

Factor Xa Inhibitors

Phase 4

HIV Protease Inhibitors

Phase 4

protease inhibitors

Phase 4

Serine Proteinase Inhibitors

Phase 4

Adrenergic Agents

Phase 4,Phase 1

Adrenergic Antagonists

Phase 4

Adrenergic beta-Antagonists

Phase 4

Anti-Arrhythmia Agents

Phase 4

Autonomic Agents

Phase 4,Phase 1

Cytochrome P-450 CYP1A2 Inhibitors

Phase 4

Cytochrome P-450 CYP2C9 Inhibitors

Phase 4

Cytochrome P-450 CYP2D6 Inhibitors

Phase 4

Cytochrome P-450 CYP3A Inhibitors

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Diuretics, Potassium Sparing

Phase 4

Neurotransmitter Agents

Phase 4,Phase 1

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Phase 1

Potassium Channel Blockers

Phase 4

Sodium Channel Blockers

Phase 4

Sympatholytics

Phase 4

Vasodilator Agents

Phase 4,Phase 2,Phase 1,Not Applicable

Phosphodiesterase 5 Inhibitors

Phase 4,Phase 2,Not Applicable

Phosphodiesterase Inhibitors

Phase 4,Phase 2,Phase 1,Not Applicable

Sildenafil Citrate

Phase 4,Phase 2,Not Applicable

171599-83-0

Antihypertensive Agents

Phase 4,Phase 3,Phase 2

Arginine Vasopressin

Phase 4

diuretics

Phase 4

Hormones

Phase 4

Natriuretic Agents

Phase 4

Sodium Potassium Chloride Symporter Inhibitors

Phase 4

Torsemide

Phase 4

Vasopressins

Phase 4

Calcium, Dietary

Phase 4

Chelating Agents

Phase 4

Citrate

Nutraceutical

Phase 4,Phase 2,Not Applicable

Iodine

Approved, Investigational

Phase 3

7553-56-2

807

Treprostinil

Approved, Investigational

Phase 3

81846-19-7

54786 6918140

Interventional clinical trials:

(show top 50) (show all 106)

#	Name	Status	NCT ID	Phase	Drugs
1	Registry for Estimation of Warfarin and Rivaroxaban in Atrial Fibrillation Patients With Coronary Stent Implantation	Unknown status	NCT02024230	Phase 4	Warfarin or Rivaroxaban
2	Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation	Unknown status	NCT02145546	Phase 4	Amiodarone;Propafenone;Sotalol
3	Tricuspid Regurgitation Study	Completed	NCT01093001	Phase 4
4	The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement	Completed	NCT02644616	Phase 4	tolvaptan+torasemide;placebo+torasemide
5	Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction	Completed	NCT02133352	Phase 4	Ranolazine
6	Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease	Completed	NCT00862043	Phase 4	Sildenafil Citrate;Placebo
7	Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension	Completed	NCT01642407	Phase 4	Sildenafil
8	Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation (HOVER)	Recruiting	NCT02339974	Phase 4
9	BOOST - Benefit of Frequent Optimization After Cardiac Resynchronization Therapy Device Replacement	Terminated	NCT00929474	Phase 4
10	Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect	Unknown status	NCT02644330	Phase 2, Phase 3
11	Comparison of Two Types of Shunts in Infants With Single Ventricle Defect Undergoing Staged Reconstruction--Pediatric Heart Network	Completed	NCT00115934	Phase 3
12	Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)	Completed	NCT00147199	Phase 3	Inhaled treprostinil;Placebo inhalation solution
13	Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride	Not yet recruiting	NCT03270514	Phase 3	Exparel Injectable Product;Bupivacaine Hydrochloride
14	NAC Phase IIB: A Multi-Center, Phase IIB, Randomized, Placebo-controlled, Double-Blind Study Of The Effects Of N-Acetylcysteine On Redox Changes and Lung Inflammation In Cystic Fibrosis Patients	Completed	NCT00809094	Phase 2	N-acetylcysteine (NAC);Placebo
15	LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection Fraction	Completed	NCT00887588	Phase 2	LCZ696;Valsartan;Placebo
16	The Effects of Fx-1006A on Transthyretin Stabilization and Clinical Outcome Measures in Patients With Non-V30M Transthyretin Amyloidosis	Completed	NCT00630864	Phase 2	Fx-1006A
17	Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System	Recruiting	NCT03331380	Phase 1, Phase 2
18	A Trial in Recombinant Human Prourokinase to Treat Acute Pulmonary Embolism	Recruiting	NCT03108833	Phase 2	Recombinant Human Prourokinase;Alteplase
19	Preventive Approach to Congenital Heart Block With Hydroxychloroquine	Recruiting	NCT01379573	Phase 2	Hydroxychloroquine
20	Longeveron Mesenchymal Stem Cells (LMSCs) Delivered During Stage II Surgery for Hypoplastic Left Heart Syndrome (ELPIS)	Recruiting	NCT03525418	Phase 1, Phase 2
21	Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Risk of Group 3 Pulmonary Hypertension	Recruiting	NCT02951429	Phase 2	Pirfenidone;Placebo;Sildenafil
22	Evaluation of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis (dcSSc)	Recruiting	NCT03274076	Phase 1, Phase 2	Tofacitinib;Placebo Oral Tablet
23	Postnatal Enalapril to Improve Cardiovascular fUnction Following Preterm Pre-eclampsia	Not yet recruiting	NCT03466333	Phase 2	Enalapril Maleate;Placebo oral capsule
24	A Phase 2, Randomized Dose-ranging Study to Evaluate the Efficacy of Tralokinumab in Adults With Idiopathic Pulmonary Fibrosis	Terminated	NCT01629667	Phase 2
25	Percutaneous Treatment of Tricuspid Valve Regurgitation With the TriCinch System™	Completed	NCT02098200	Phase 1
26	Quantifying the Presence of Lung Disease and Pulmonary Hypertension in Children With Sickle Cell Disease	Completed	NCT01895998	Phase 1	Albuterol
27	Inhaled Milrinone Use in Patients Receiving HeartMate II LVAD: A Pilot Study	Completed	NCT01571037	Phase 1	Inhaled, nebulized, Milrinone;inhaled nebulized milrinone
28	Effects of GSK1278863A on Pulmonary Artery Pressure in Healthy Volunteers	Completed	NCT01673555	Phase 1	GSK1278863;Placebo
29	Study of GSK2586881 on Acute Hypoxia and Exercise	Recruiting	NCT03000686	Phase 1
30	Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome	Recruiting	NCT02398604	Phase 1	Allo-hMSCs;Placebo
31	Autologous Cardiac Stem Cell Injection in Patients With Hypoplastic Left Heart Syndrome: An Open Label Pilot Study.	Not yet recruiting	NCT03406884	Phase 1	c-kit+ cells;Placebo
32	Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases	Unknown status	NCT02721524	Not Applicable
33	Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart	Unknown status	NCT01444222
34	Treatment of Severe Secondary TRIcuspid Regurgitation in Patients With Advance Heart Failure With CAval Vein Implantation of the Edwards Sapien XT VALve (TRICAVAL)	Unknown status	NCT02387697	Not Applicable
35	Prophylactic Tricuspid Valve Annuloplasty in Patients Undergoing Mitral Valve Surgery	Unknown status	NCT01580436	Not Applicable
36	The Impact of Right Ventricular Pacing on Tricuspid Regurgitation	Unknown status	NCT00419354
37	Long-term Outcome After Isolated Tricuspid Valve Repair	Unknown status	NCT01537458
38	Reversibility by Sildenafil of Exercise-Induced Abnormal Right Ventricular Pressure Response in ASD and VSD-Operated Patients	Unknown status	NCT00772135	Not Applicable	sildenafil citrate
39	Is There a Correlation Between the Pulmonary Artery Pressure and the Acceleration of the Flow in the Pulmonary Artery Evaluated by Transesophageal Echocardiography (TOE) ?	Unknown status	NCT01947257	Not Applicable
40	Evaluation of the Prevalence of Pulmonary Hypertension in Adult Patients With Sickle Cell Disease	Unknown status	NCT00434902
41	Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation	Completed	NCT01246947	Not Applicable
42	Prognostic Value of Early Postoperative Right Ventricular Systolic Function in Patients With Isolated Severe Tricuspid Regurgitation	Completed	NCT01203137
43	The Comparison of Tricuspid Replacement and Repair in Patients With Combined Heart Valve Disease	Completed	NCT01246141
44	EASE TRICUSPID Expertise-based Assessment Study on Clinical Efficacy of Contour 3D® in TRICUSPID Valve Annuloplasty	Completed	NCT01532921
45	Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial	Completed	NCT01585779
46	Serum Brain Natriuretic Peptide Levels and Pulmonary Hypertension in Pediatric Sickle Cell Patients	Completed	NCT01023451
47	Acute Normovolemic Hemodilution on Serum-creatinine Concentration in Cardiac Surgery	Completed	NCT02831270		hydroxyethyl starch (HES 130/0.6)
48	Acute Normovolemic Hemodilution on ROTEM in Cardiac Surgery	Completed	NCT02502448	Not Applicable	hydroxyethyl starch (HES 130/0.6)
49	Long Term Effects of Erythrocyte Lysis	Completed	NCT00842621
50	Coenzyme Q-10 and Pulmonary Arterial Hypertension	Completed	NCT01148836	Not Applicable

Search NIH Clinical Center for Tricuspid Valve Insufficiency

Cochrane evidence based reviews: tricuspid valve insufficiency

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Genetic Tests for Tricuspid Valve Insufficiency

Genetic tests related to Tricuspid Valve Insufficiency:

#	Genetic test	Affiliating Genes
1	Tricuspid Regurgitation ²⁹

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Anatomical Context for Tricuspid Valve Insufficiency

MalaCards organs/tissues related to Tricuspid Valve Insufficiency:

⁴¹

Heart, Brain, Lung, Liver, Testes

Sources

Publications for Tricuspid Valve Insufficiency

Articles related to Tricuspid Valve Insufficiency:

(show all 23)

#	Title	Authors	Year
1	A systematic method for using 3D echocardiography to evaluate tricuspid valve insufficiency in hypoplastic left heart syndrome. ( 25298694 )	Mart C.R....Su J.T.	2014
2	Surgical treatment of tricuspid valve insufficiency promotes early reverse remodeling in patients with axial-flow left ventricular assist devices. ( 21839483 )	Maltais S....Park S.J.	2012
3	Pulmonary arterial pressure and right ventricular dilatation independently determine tricuspid valve insufficiency severity in pre-capillary pulmonary hypertension. ( 23409355 )	De Meester P....Budts W.	2012
4	Recurrent protein-losing enteropathy and tricuspid valve insufficiency in a transplanted heart: a causal relationship? ( 21801319 )	Aggarwal S....L'Ecuyer T.J.	2012
5	The clover technique for the treatment of complex tricuspid valve insufficiency: midterm clinical and echocardiographic results in 66 patients. ( 20117940 )	Lapenna E....Alfieri O.	2010
6	Retrospective analysis of stage I Norwood procedures with tricuspid valve insufficiency in the past 5 years. ( 17669787 )	Ota N....Sakamoto K.	2007
7	Cardiac bullet embolus after thoracic vena cava penetrating injury causing tricuspid valve insufficiency. ( 17386917 )	Ettinger J....Fahel E.	2007
8	Acute liver failure as the first manifestation of severe traumatic tricuspid valve insufficiency. ( 16432673 )	Koroneos A....Roussos C.	2006
9	Diagnosis and treatment of traumatic tricuspid valve insufficiency. ( 14642061 )	Jiang C.L....Xiu Z.Y.	2003
10	Traumatic tricuspid valve insufficiency: case report. ( 11499605 )	Leszek P....Korewicki J.	2001
11	Post-traumatic tricuspid valve insufficiency. 2 cases of delayed clinical manifestation. ( 9339514 )	Bortolotti U....Balbarini A.	1997
12	Fetal and transient neonatal right heart dilatation with severe tricuspid valve insufficiency in association with abnormally S-shaped kinking of the ductus arteriosus. ( 7614140 )	Mielke G....Gembruch U.	1995
13	Repair of traumatic tricuspid valve insufficiency by trabecular muscle elevation. ( 7887723 )	van Son J.A....Starr A.	1995
14	Traumatic tricuspid valve insufficiency. Experience in thirteen patients. ( 7967672 )	van Son J.A....Miller F.A.	1994
15	Tricuspid valve insufficiency as a complication of endomyocardial biopsy. ( 14621794 )	Wiklund L....Berglin E.	1992
16	Endocardial fibroelastosis and tricuspid valve insufficiency in a calf. ( 3610756 )	Scarratt W.K....Gardner D.	1987
17	Repair of tricuspid valve insufficiency in patients undergoing double (aortic and mitral) valve replacement. Perioperative mortality and long-term (1 to 20 years) follow-up in 109 patients. ( 3669702 )	Mullany C.J....Danielson G.K.	1987
18	Transient tricuspid valve insufficiency following acute inferior myocardial infarction. ( 3485873 )	Huyghens L....Defoer F.	1986
19	Management of tricuspid valve insufficiency. Replacement with Hancock bioprosthesis or suture annuloplasty. ( 511908 )	Jara F.M....Davila J.C.	1979
20	&quot;Balloon valvulotomy&quot; of congenital pulmonary valve stenosis with tricuspid valve insufficiency. ( 519671 )	Semb B.K....Aabyholm G.	1979
21	Dynamic tricuspid valve insufficiency produced by a right ventricular thrombus from a pacemaker. ( 699661 )	Zager J....Klieman C.	1978
22	[D-transposition in situs inversus, atrial septal defect, open foramen ovale and tricuspid valve insufficiency]. ( 997709 )	Weikl A....Stolte M.	1976
23	An interventricular septal defect and a tricuspid valve insufficiency in a trotter mare. ( 4426317 )	Muylle E....Van den Hende C.	1974

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Genes for Tricuspid Valve Insufficiency

Genes related to Tricuspid Valve Insufficiency (1 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PTPN11	Protein Tyrosine Phosphatase, Non-Receptor Type 11	Protein Coding	400	Pathogenic ⁶
2	NPPB	Natriuretic Peptide B	Protein Coding	21.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	17934262 16320975 15520111 (more) 18545065 19616677 20197576 19011393 16959341 12480042 17228802
3	MC3R	Melanocortin 3 Receptor	Protein Coding	17.25	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	16.47	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	ZIC3	Zic Family Member 3	Protein Coding	16.13	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	CRELD1	Cysteine Rich With EGF Like Domains 1	Protein Coding	15.84	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	CA6	Carbonic Anhydrase 6	Protein Coding	15.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	ARSE	Arylsulfatase E (Chondrodysplasia Punctata 1)	Protein Coding	15.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	TTC1	Tetratricopeptide Repeat Domain 1	Protein Coding	15.1	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	FBN1	Fibrillin 1	Protein Coding	15.1	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	ALB	Albumin	Protein Coding	15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	SMG6	SMG6, Nonsense Mediated MRNA Decay Factor	Protein Coding	14.95	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	PAPPA	Pappalysin 1	Protein Coding	11.31	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	16388509 20466286

Sources

Variations for Tricuspid Valve Insufficiency

ClinVar genetic disease variations for Tricuspid Valve Insufficiency:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	PTPN11	NM_002834.4(PTPN11): c.184T> G (p.Tyr62Asp)	single nucleotide variant	Pathogenic	rs121918460	GRCh37	Chromosome 12, 112888168: 112888168
2	PTPN11	NM_002834.4(PTPN11): c.184T> G (p.Tyr62Asp)	single nucleotide variant	Pathogenic	rs121918460	GRCh38	Chromosome 12, 112450364: 112450364
3		46;XX;ins(5;6)(p13;p24p25)dn	Translocation	Pathogenic
4		46;XX;inv(14)(q24.1q32.1)dn	inversion	Uncertain significance
5	MYH11	NM_001040113.1(MYH11): c.4381G> C (p.Asp1461His)	single nucleotide variant	Likely pathogenic	rs1057518938	GRCh38	Chromosome 16, 15724166: 15724166
6	MYH11	NM_001040113.1(MYH11): c.4381G> C (p.Asp1461His)	single nucleotide variant	Likely pathogenic	rs1057518938	GRCh37	Chromosome 16, 15818023: 15818023

Sources

Expression for Tricuspid Valve Insufficiency

Search GEO for disease gene expression data for Tricuspid Valve Insufficiency.

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Pathways for Tricuspid Valve Insufficiency

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GO Terms for Tricuspid Valve Insufficiency

Biological processes related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular protein metabolic process	GO:0044267	9.13	ALB FBN1 PAPPA
2	regulation of blood pressure	GO:0008217	8.8	ACVRL1 MC3R NPPB

Sources

Sources for Tricuspid Valve Insufficiency

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia