MCID: TRC022
MIFTS: 49

Tricuspid Valve Insufficiency

Categories: Blood diseases, Cardiovascular diseases
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Aliases & Classifications for Tricuspid Valve Insufficiency

MalaCards integrated aliases for Tricuspid Valve Insufficiency:

Name: Tricuspid Valve Insufficiency 11 43 14 71 33
Tricuspid Regurgitation 11 28 53 5 14 75
Tricuspid Valve Regurgitation 11 33
Tricuspid Valve Annular Incompetency 33
Tr - [tricuspid Regurgitation] 33
Tricuspid Valve Incompetency 33
Tricuspid Incompetence 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4080
MeSH 43 D014262
NCIt 49 C50842
SNOMED-CT 68 111287006
UMLS 71 C0040961

Summaries for Tricuspid Valve Insufficiency

Disease Ontology: 11 A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.

MalaCards based summary: Tricuspid Valve Insufficiency, also known as tricuspid regurgitation, is related to atrioventricular block and third-degree atrioventricular block. An important gene associated with Tricuspid Valve Insufficiency is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are Signal Transduction and Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs Torasemide and Tolvaptan have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and brain, and related phenotypes are normal and muscle

Wikipedia: 75 Tricuspid regurgitation (TR), also called tricuspid insufficiency, is a type of valvular heart disease... more...

Related Diseases for Tricuspid Valve Insufficiency

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 656)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 30.9 TNNT2 TNNI3 NPPB CRP ACE
2 third-degree atrioventricular block 30.8 TNNI3 REN NPPB CRP ACE
3 atrial fibrillation 30.7 TNNI3 NR3C2 NPPB F3 F2 CRP
4 hyperthyroidism 30.7 REN GPT F2 CRP ALB
5 tricuspid valve stenosis 30.6 NPPB F3
6 persistent fetal circulation syndrome 30.6 PDE5A EDN1 ALB
7 hypoplastic left heart syndrome 30.6 TNNT2 TNNI3 NPPB ACE
8 heart septal defect 30.5 TNNT2 PTPN11 NPPB F3 F2 CRP
9 sickle cell anemia 30.5 F3 F2 EDN1 CRP ALB
10 kawasaki disease 30.5 NPPB GPT CRP
11 right bundle branch block 30.5 TNNT2 TNNI3 NPPB CRP ACE
12 rheumatic fever 30.5 NPPB ALB ACE
13 chromosomal triplication 30.5 PAPPA CGB3
14 pulmonary valve insufficiency 30.5 REN PDE5A NPPB EDN1 CRP BMPR2
15 congenitally corrected transposition of the great arteries 30.4 TNNT2 NPPB
16 coronary stenosis 30.4 TNNI3 NPPB CRP ACE
17 libman-sacks endocarditis 30.4 F2 CRP
18 cardiac arrest 30.3 TNNT2 TNNI3 NPPB CRP ACE
19 lung abscess 30.3 GPT CRP ALB
20 peripheral artery disease 30.3 REN NPPB CRP ALB ACE
21 pulmonary disease, chronic obstructive 30.3 PDE5A NPPB CRP ALB ACE
22 inferior myocardial infarction 30.3 TNNT2 TNNI3 NPPB ACE
23 endocarditis 30.3 TNNT2 TNNI3 F2 CRP ALB
24 bronchopneumonia 30.3 GPT CRP ALB
25 orthostatic intolerance 30.2 REN MYH11 CRP ACE
26 protein-losing enteropathy 30.2 GPT F2 CRP ALB
27 amyloidosis, hereditary, transthyretin-related 30.2 TNNT2 NPPB ALB
28 nutritional deficiency disease 30.2 F2 CRP ALB
29 aortic valve disease 2 30.2 TNNT2 TNNI3 REN NPPB CRP ACE
30 immunoglobulin light chain amyloidosis 30.1 TNNT2 TNNI3 NPPB ALB
31 pleural empyema 30.1 GPT F2 CRP ALB
32 left ventricular noncompaction 30.1 TNNT2 TNNI3 PTPN11 ACE
33 polycythemia vera 30.1 PTPN11 F3 F2 CRP
34 thrombocytosis 30.1 F3 F2 CRP ALB
35 pericarditis 30.1 TNNT2 TNNI3 NPPB CRP ACE
36 beta-thalassemia 30.0 NPPB GPT F2 CRP
37 aortic dissection 30.0 TNNT2 MYH11 CRP ALB ACE
38 hemopneumothorax 30.0 GPT F3 F2 CRP
39 hemopericardium 30.0 TNNI3 NPPB F3 F2 CRP
40 transient cerebral ischemia 30.0 REN NPPB F3 F2 CRP ALB
41 hypersplenism 30.0 GPT F3 F2 ALB
42 restrictive cardiomyopathy 30.0 TNNT2 TNNI3 REN NR3C2 NPPB CRP
43 sleep disorder 30.0 REN EDN1 CRP ALB ACE
44 disseminated intravascular coagulation 30.0 GPT F3 F2 CRP
45 budd-chiari syndrome 30.0 GPT F3 F2 ALB
46 infective endocarditis 30.0 NPPB F3 F2 CRP ALB ACE
47 aortic disease 30.0 REN NPPB MYH11 CRP ALB ACE
48 pancytopenia 29.9 GPT F2 CRP ALB ACE
49 hepatopulmonary syndrome 29.9 EDN1 CRP BMPR2 ALB ACE
50 arteries, anomalies of 29.9 TNNI3 REN EDN1 CRP ALB ACE

Graphical network of the top 20 diseases related to Tricuspid Valve Insufficiency:



Diseases related to Tricuspid Valve Insufficiency

Symptoms & Phenotypes for Tricuspid Valve Insufficiency

GenomeRNAi Phenotypes related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 ACE ALB BMPR2 CGB3 CRP EDN1
2 no effect GR00402-S-2 10.18 ACE ALB BMPR2 CRP EDN1 F2

MGI Mouse Phenotypes related to Tricuspid Valve Insufficiency:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 10.07 ALB BMPR2 EDN1 F2 F3 PAPPA
2 muscle MP:0005369 10.03 ALB BMPR2 EDN1 F2 F3 MYH11
3 homeostasis/metabolism MP:0005376 10.03 ACE ALB BMPR2 CGB3 CRP EDN1
4 renal/urinary system MP:0005367 9.92 ACE ALB BMPR2 EDN1 MC3R MYH11
5 growth/size/body region MP:0005378 9.8 ACE BMPR2 CGB3 EDN1 F2 F3
6 cardiovascular system MP:0005385 9.53 ACE ALB BMPR2 CRP EDN1 F2

Drugs & Therapeutics for Tricuspid Valve Insufficiency

Drugs for Tricuspid Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Torasemide Approved Phase 4 56211-40-6 41781
2
Tolvaptan Approved Phase 4 150683-30-0 216237
3 Arginine Vasopressin Phase 4
4 Vasopressins Phase 4
5 Sodium Potassium Chloride Symporter Inhibitors Phase 4
6
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
7
Carvedilol Approved, Investigational Phase 3 72956-09-3 2585
8
Empagliflozin Approved Phase 3 864070-44-0 73151030 11949646
9 Kava Approved, Investigational, Nutraceutical Phase 2, Phase 3 9000-38-8
10 Anesthetics Phase 3
11 Anesthetics, Local Phase 3
12 Pharmaceutical Solutions Phase 3
13 Hormones Phase 3
14 Antihypertensive Agents Phase 3
15 Neurotransmitter Agents Phase 3
16 Adrenergic beta-Antagonists Phase 3
17 Adrenergic Antagonists Phase 3
18 Adrenergic alpha-Antagonists Phase 3
19 Adrenergic alpha-1 Receptor Antagonists Phase 3
20 Adrenergic Agents Phase 3
21 Vasodilator Agents Phase 3
22 Calcium, Dietary Phase 3
23 Sodium-Glucose Transporter 2 Inhibitors Phase 3
24 Hypoglycemic Agents Phase 3
25 calcium channel blockers Phase 3
26 Antioxidants Phase 3
27 Protective Agents Phase 3
28
Calcium Nutraceutical Phase 3 7440-70-2 271
29
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
30
Milrinone Approved 78415-72-2 4197
31 Natriuretic Peptide, Brain
32 Epinephryl borate
33 Angiotensin Receptor Antagonists
34 diuretics

Interventional clinical trials:

(show top 50) (show all 116)
# Name Status NCT ID Phase Drugs
1 The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement Completed NCT02644616 Phase 4 tolvaptan+torasemide;placebo+torasemide
2 Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation HOVER Trial Completed NCT02339974 Phase 4
3 The Effect of Cardiac Pacing Leads on Tricuspid Regurgitation Completed NCT01093001 Phase 4
4 Postoperative Analgesia After Cardiac Surgery - A Double-Blind, Prospective and Randomized Comparison of Wound Infiltration With Liposomal Bupivacaine and Bupivacaine Hydrochloride Completed NCT03270514 Phase 3 Exparel Injectable Product;Bupivacaine Hydrochloride
5 Multicenter, Randomized, 2 x 2 Factorial, Phase 3 Study to Assess the Efficacy of Carvedilol and Empagliflozin on Improvement of Right Ventricular Remodeling in Patients With Severe Functional Tricuspid Regurgitation Recruiting NCT04345796 Phase 3 Carvedilol+Empagliflozin;Carvedilol;Empagliflozin;Placebo
6 Treatment of Severe Secondary TRIcuspid Regurgitation in Patients With Advance Heart Failure With CAval Vein Implantation of the Edwards Sapien XT VALve Terminated NCT02387697 Phase 2, Phase 3
7 Percutaneous Treatment of Tricuspid Valve Regurgitation With the TriCinch System™ Completed NCT02098200 Phase 1
8 Comparison Between Outcomes Of Ring And Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Unknown status NCT02721524
9 Early Feasibility of the Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) for Symptomatic Chronic Functional Tricuspid Regurgitation Unknown status NCT02574650
10 The Impact of Right Ventricular Pacing on Tricuspid Regurgitation Unknown status NCT00419354
11 Left Ventricular Pacing to Prevent Iatrogenic Tricuspid Regurgitation Caused by Conventional Right Ventricular Pacing: a Pilot Study Unknown status NCT02314897
12 Cardiac Remodeling and Prognosis in Secondar Tricuspid Regurgitation Unknown status NCT03159923
13 Multi-centre Randomised Trial Investigating the Effect of PROphylactic triCuspID Annuloplasty in Patients With Dilated Tricuspid Annulus on Tricuspid Regurgitation Progression, Right Ventricular Remodeling and Functional Outcomes Unknown status NCT03129737
14 Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) for Symptomatic Chronic Functional Tricuspid Regurgitation Unknown status NCT03225612
15 Transcatheter Treatment of Severe Tricuspid Regurgitation Using the MitraClip System Unknown status NCT02863549
16 Echo-Guided Tricuspid Valve Surgery Vs. Conservative Approach At The Time Of Left- Sided Valve Surgery. A Prospective Randomized Study Unknown status NCT03278418
17 Long-term Outcome After Isolated Tricuspid Valve Repair Unknown status NCT01537458
18 Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart Unknown status NCT01444222
19 Prospective, Randomized Evaluation of Prophylactic Tricuspid Valve Annuloplasty in Patients Undergoing Mitral Valve Surgery Unknown status NCT01580436
20 Outcome of MC3 Ring Annuloplasty for Moderate and Severe Functional Tricuspid Regurgitation Associated With Rheumatic Mitral Valve Disease Completed NCT04078867
21 TRICUS STUDY - Safety and Efficacy of the TricValve® Transcatheter Bicaval Valves System in the Superior and Inferior Vena Cava in Patients With Severe Tricuspid Regurgitation. Completed NCT03723239
22 TRICUS STUDY EURO - Safety and Efficacy of the TricValve® Transcatheter Bicaval Valves System in the Superior and Inferior Vena Cava in Patients With Severe Tricuspid Regurgitation Completed NCT04141137
23 TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System Completed NCT02981953
24 Incidence of Residual Significant Tricuspid Regurgitation in Patients Undergoing Left-sided Cardiac Surgery Completed NCT04414358
25 Prevention of Pacemaker Lead Induced Tricuspid regurgitAtion by Transesophageal eCho guidEd Implantation Registry Completed NCT04945005
26 A Prospective Randomized Trial of Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Mitral Operation Completed NCT01246947
27 Prognostic Value of Early Postoperative Right Ventricular Systolic Function in Patients With Isolated Severe Tricuspid Regurgitation Completed NCT01203137
28 Biomarkers in Aortic Stenosis, Hypertrophic Cardiomyopathy, Mitral Regurgitation, Aortic Regurgitation, Prosthetic Heart Valve Dysfunction, and Tricuspid Regurgitation From Pacemaker Leads Study Completed NCT01334801
29 Evaluation of Mitral and Tricuspid Regurgitation: Cardiovascular Magnetic Resonance Imaging Versus Echocardiographic Doppler Color Flow Mapping of the Vena Contracta Completed NCT01504880
30 Prospective Registry of Patients With Isolated Severe Tricuspid Regurgitation Completed NCT01502462
31 Validation Study Comparing the Cardiac Output Pulmonary Arterial Catheter (Swan Ganz) to the FloWave™ 1000 Device Completed NCT00665301
32 Phonokardiographie Bei Erwachsenen Completed NCT03600051
33 Impact of Acute Normovolemic Hemodilution on Whole Blood Coagulation Profile During Post-cardiopulmonary Bypass in Cardiac Surgery: Rotational Thromboelastometry Study Completed NCT02502448 hydroxyethyl starch (HES 130/0.6)
34 Comparison of Rigid Annuloplasty Ring With a Band in the Correction of Secondary Tricuspid Insufficiency Completed NCT03144024
35 Does Acute Normovolemic Hemodilution Affect Intraoperative Value of Serum-creatinine Concentration in Patients Undergoing Cardiac Surgery? Completed NCT02831270 hydroxyethyl starch (HES 130/0.6)
36 Prophylactic Tricuspid Annuloplasty During Mitral Valve Surgery Completed NCT03604484
37 Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial Completed NCT01585779
38 EASE TRICUSPID Expertise-based Assessment Study on Clinical Efficacy of Contour 3D® in TRICUSPID Valve Annuloplasty Completed NCT01532921
39 The SPACER Trial - Repair of Tricuspid Valve Regurgitation Using the Edwards TricuSPid TrAnsCatheter REpaiR System Completed NCT02787408
40 The Institute of Cardiovascular Surgery Completed NCT01246141
41 Transcatheter Repair of Tricuspid Regurgitation With Cardioband TR System Post-Market Clinical Follow-Up Study (TriBAND): A European Prospective, Multicenter Post-market Clinical Follow-up Study to Assess Transcatheter Tricuspid Valve Repair With Edwards Cardioband TR System in Patients With Symptomatic Chronic Functional Tricuspid Regurgitation. Recruiting NCT03779490
42 Risk Stratification in Patients With Severe Tricuspid Regurgitation: Insights From the TRicuspid Regurgitation rEgistry (TRuE) Recruiting NCT04173091
43 Clinical and Echocardiographic Characteristics and Prognosis of trIcuspid regurgiTation (EPIT): Prospective and Retrospective Follow-up of a Cohort of Patients With Moderate or Severe Tricuspid Regurgitation Recruiting NCT03546231
44 Measurement of Tricuspid Regurgitation Volume for Assessment of Tricuspid Regurgitation Using 3D Transesophageal Echocardiography Recruiting NCT05130775
45 Minimally Invasive Tricuspid Surgery Versus Medical Treatment for Severe Tricuspid Regurgitation After Left-sided Valve Surgery Recruiting NCT04339192
46 Prospective, Single Arm, Multi-center, First-in-human (FIH) Study to Assess the Safety and Performance of the Innoventric Trillium™ Stent Graft for the Treatment of Severe Tricuspid Regurgitation (TR) Recruiting NCT04289870
47 Tricuspid Regurgitation Hamburg Cohort Recruiting NCT04755842
48 Transcatheter Repair of Tricuspid Regurgitation With Edwards PASCAL Transcatheter Valve Repair System: A European Prospective, Multicenter Post-Market Clinical Follow up Recruiting NCT04614402
49 Annuloplasty for the Treatment of Not-Severe Tricuspid Regurgitation in Patients Undergoing Surgery for Mitral Valve Disease: a Prospective, Spontaneous, Multicentre, Randomized Study Recruiting NCT02996552
50 Evaluation of the Safety, Efficacy and Cost-effectiveness of Transcatheter Tricuspid Valve Repair in Patients With Severe Tricuspid Regurgitation in the Netherlands Recruiting NCT05628779

Search NIH Clinical Center for Tricuspid Valve Insufficiency

Cochrane evidence based reviews: tricuspid valve insufficiency

Genetic Tests for Tricuspid Valve Insufficiency

Genetic tests related to Tricuspid Valve Insufficiency:

# Genetic test Affiliating Genes
1 Tricuspid Regurgitation 28

Anatomical Context for Tricuspid Valve Insufficiency

Organs/tissues related to Tricuspid Valve Insufficiency:

MalaCards : Heart, Liver, Brain, Whole Blood, Lung, Atrioventricular Node, Kidney

Publications for Tricuspid Valve Insufficiency

Articles related to Tricuspid Valve Insufficiency:

(show top 50) (show all 7487)
# Title Authors PMID Year
1
A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data. 5
29555671 2018
2
Prenatal sonographic features of fetuses in trisomy 13 pregnancies. IV. 53 62
20466286 2010
3
Clinical utility of B-type natriuretic peptide for estimating left ventricular filling pressures in unselected elderly patients undergoing diagnostic coronary angiography. 53 62
20197576 2010
4
Application of classic heart failure definitions of asymptomatic and symptomatic ventricular dysfunction and heart failure symptoms with preserved ejection fraction to patients with systemic right ventricles. 53 62
19616677 2009
5
Elevated serum cobalamin in patients with decompensated biventricular failure. 53 62
19011393 2008
6
Right heart dysfunction assessed with echography, B-type natriuretic peptide and cardiopulmonary test in patients with chronic heart failure. 53 62
18545065 2008
7
B-type natriuretic peptide in patients with systemic right ventricle. 53 62
17934262 2008
8
Assessment of factors affecting plasma BNP levels in patients with chronic atrial fibrillation and preserved left ventricular systolic function. 53 62
16959341 2007
9
[The stady of pulmonary hypertension and plasma BNP values in respiratory diseases]. 53 62
17228802 2006
10
Screening for trisomy 21 by fetal tricuspid regurgitation, nuchal translucency and maternal serum free beta-hCG and PAPP-A at 11 + 0 to 13 + 6 weeks. 53 62
16388509 2006
11
[Feasibility of cardiopulmonary rehabilitation in patients with idiopathic pulmonary arterial hypertension treated with intravenous prostacyclin infusion therapy]. 53 62
16320975 2005
12
Brain-type natriuretic peptide in the diagnosis and management of persistent pulmonary hypertension of the newborn. 53 62
15520111 2004
13
Usefulness of B-type natriuretic peptide levels in predicting hemodynamic perturbations after heart transplantation despite preserved left ventricular systolic function. 53 62
12480042 2002
14
A case of gastric antral vascular ectasia in which PuraStat, a novel self-assembling peptide hemostatic hydrogel, was effective. 62
36381641 2023
15
Prognostic Value of Nonalcoholic Fatty Liver Disease in Patients With Severe Aortic Stenosis Who Underwent Transcatheter Aortic Valve Implantation. 62
36319504 2023
16
Guiding Interventions for Secondary Tricuspid Regurgitation: Follow the Intricate Interplay Between Form and Function. 62
34495894 2023
17
First Trimester Tricuspid Regurgitation: Clinical Significance. 62
36475342 2022
18
Anterior leaflet-oriented tricuspid annuloplasty using a flexible ring for severe tricuspid regurgitation. 62
35107639 2022
19
Tricuspid leaflet kinematics after annular size reduction in ovine functional tricuspid regurgitation. 62
33685738 2022
20
Area of the right atrium of the fetal heart and its significance in fetuses with tricuspid regurgitation. 62
33478280 2022
21
Comparison of Residual Tricuspid Regurgitation Severity Assessed by Intraprocedural and Postprocedural Echocardiography in Patients Undergoing Transcatheter Tricuspid Valve Repair. 62
36180287 2022
22
Unsupervised Machine Learning for Assessment of Left Ventricular Diastolic Function and Risk Stratification. 62
35840082 2022
23
Prognostic Impact of Indeterminate Diastolic Function in Patients with Functionally Insignificant Coronary Stenosis. 62
36470507 2022
24
Efficacy and Safety of Concomitant Tricuspid Repair in Patients Undergoing Mitral Valve Surgery: a Systematic Review and Meta-Analysis. 62
36007619 2022
25
Concomitant tricuspid valve repair in left ventricular assist device implantation may increase the risk for temporary right ventricular support but does not impact overall outcomes. 62
36469336 2022
26
Will clinical signs become myth? Developing structured Signs Circuits to improve medical students' exposure to and confidence examining clinical signs. 62
35388743 2022
27
Outcome of Pregnancy in Women With D-Transposition of the Great Arteries: A Systematic Review. 62
36444833 2022
28
Contemporary outcomes of the double switch operation for congenitally corrected transposition of the great arteries. 62
35688715 2022
29
No evidence of pulmonary hypertension revealed in an echographic evaluation of right-sided hemodynamics in hyperthyroid cats. 62
36350661 2022
30
Safety and Efficacy of Sacubitril/Valsartan in Patients With a Failing Systemic Right Ventricle: A Prospective Single-Center Study. 62
36458541 2022
31
Heterotopic Transcatheter Tricuspid Valve Replacement in a Patient With Carcinoid Heart Disease. 62
36438434 2022
32
Estimation of Left Ventricular Filling Pressure Using Left Atrial Strain in Coarctation of Aorta. 62
36328516 2022
33
Echocardiographic assessment and clinical implication of functional tricuspid regurgitation in heart failure with reduced or preserved ejection fraction (ECLIPSE-HF) : Rationale and design of the study. 62
36445668 2022
34
Tricuspid Regurgitation and Right Ventricular Function in Patients Undergoing Percutaneous Treatment of Mitral Regurgitation. 62
36328515 2022
35
Critical care echocardiography in prone position patients during COVID-19 pandemic: a feasibility study. 62
35229275 2022
36
Subsequent cardiac surgery after transcatheter aortic valve implantation: Indications and outcomes. 62
36378828 2022
37
Original technique for tricuspid valve replacement by mitral homograft: Step-by-step approach and initial results. 62
36378863 2022
38
Severe Covid-19 and acute pulmonary hypertension: 24-month follow-up regarding mortality and relationship to initial echocardiographic findings and biomarkers. 62
36333823 2022
39
Prevalence and risk prediction value of tricuspid regurgitation by echocardiography in precapillary pulmonary hypertension. 62
36352385 2022
40
Risk of bleeding associated with transbronchial biopsy using flexible bronchoscopy in patients with echocardiographic or chest CT evidence of pulmonary hypertension. 62
36443763 2022
41
Adaptive versus maladaptive right ventricular remodelling. 62
36419369 2022
42
Echocardiographic changes after arteriovenous fistula creation in hemodialysis patients. 62
36168799 2022
43
Tricuspid valve detachment for ventricular septal defect closure: A meta-analysis of existing evidence. 62
36378918 2022
44
Tricuspid regurgitation in His bundle pacing: A systematic review. 62
35763445 2022
45
Surgical approach to combined mitral and tricuspid valve disease: good neighbourhood rules. 62
36380807 2022
46
The hepato-cardiac disorders in Tibetan residents with hepatic echinococcosis: A case-control echocardiography study. 62
36353905 2022
47
Redo heart transplantation in a high-risk patient due to severe aortic regurgitation and accompanying right ventricular failure after LVAD implantation and temporary RVAD support. 62
36321720 2022
48
Surgical edge-to-edge repair for tricuspid regurgitation: Impact of the concomitant annuloplasty. 62
36455700 2022
49
Delay of surgical treatment of severe tricuspid regurgitation and outcomes in patients with left-sided heart valve disease. 62
36427786 2022
50
Acquired left ventricular-right atrial communication after mitral valve replacement and tricuspid annuloplasty. 62
36047411 2022

Variations for Tricuspid Valve Insufficiency

ClinVar genetic disease variations for Tricuspid Valve Insufficiency:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 PTPN11 NM_002834.5(PTPN11):c.184T>G (p.Tyr62Asp) SNV Pathogenic
13329 rs121918460 GRCh37: 12:112888168-112888168
GRCh38: 12:112450364-112450364
2 MYH11, NDE1 NM_002474.3(MYH11):c.4360G>C (p.Asp1454His) SNV Likely Pathogenic
374162 rs1057518938 GRCh37: 16:15818023-15818023
GRCh38: 16:15724166-15724166
3 GATA4 NM_001308093.3(GATA4):c.1276G>A (p.Asp426Asn) SNV Uncertain Significance
9034 rs56208331 GRCh37: 8:11615928-11615928
GRCh38: 8:11758419-11758419

Expression for Tricuspid Valve Insufficiency

Search GEO for disease gene expression data for Tricuspid Valve Insufficiency.

Pathways for Tricuspid Valve Insufficiency

Pathways related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 13.02 PTPN11 PDE5A NDE1 MYH11 MC3R F3
2
Show member pathways
10.28 PTPN11 EDN1 CRP

GO Terms for Tricuspid Valve Insufficiency

Cellular components related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.68 REN PAPPA NPPB GPT F3 F2
2 cardiac myofibril GO:0097512 9.46 TNNT2 TNNI3
3 cardiac Troponin complex GO:1990584 9.26 TNNT2 TNNI3

Biological processes related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone-mediated signaling pathway GO:0009755 9.85 REN PTPN11 CGB3
2 blood vessel diameter maintenance GO:0097746 9.65 NPPB EDN1 ACE
3 vasoconstriction GO:0042310 9.63 EDN1 CRP ACE
4 body fluid secretion GO:0007589 9.62 NPPB EDN1
5 response to dexamethasone GO:0071548 9.43 PAPPA EDN1 ACE
6 regulation of blood pressure GO:0008217 9.28 REN NPPB MC3R EDN1 ACE

Molecular functions related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin C binding GO:0030172 8.92 TNNT2 TNNI3

Sources for Tricuspid Valve Insufficiency

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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