Tricuspid Valve Insufficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal.

MalaCards based summary: Tricuspid Valve Insufficiency, also known as tricuspid regurgitation, is related to atrioventricular block and third-degree atrioventricular block. An important gene associated with Tricuspid Valve Insufficiency is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are Signal Transduction and Development_Leptin signaling via JAK/STAT and MAPK cascades. The drugs Torasemide and Tolvaptan have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and brain, and related phenotypes are normal and muscle

Wikipedia: ⁷⁵ Tricuspid regurgitation (TR), also called tricuspid insufficiency, is a type of valvular heart disease... more...

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Related Diseases for Tricuspid Valve Insufficiency

Diseases in the Tricuspid Valve Disease family:

Tricuspid Valve Insufficiency

Diseases related to Tricuspid Valve Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 656)

#	Related Disease	Score	Top Affiliating Genes
1	atrioventricular block	30.9	TNNT2 TNNI3 NPPB CRP ACE
2	third-degree atrioventricular block	30.8	TNNI3 REN NPPB CRP ACE
3	atrial fibrillation	30.7	TNNI3 NR3C2 NPPB F3 F2 CRP
4	hyperthyroidism	30.7	REN GPT F2 CRP ALB
5	tricuspid valve stenosis	30.6	NPPB F3
6	persistent fetal circulation syndrome	30.6	PDE5A EDN1 ALB
7	hypoplastic left heart syndrome	30.6	TNNT2 TNNI3 NPPB ACE
8	heart septal defect	30.5	TNNT2 PTPN11 NPPB F3 F2 CRP
9	sickle cell anemia	30.5	F3 F2 EDN1 CRP ALB
10	kawasaki disease	30.5	NPPB GPT CRP
11	right bundle branch block	30.5	TNNT2 TNNI3 NPPB CRP ACE
12	rheumatic fever	30.5	NPPB ALB ACE
13	chromosomal triplication	30.5	PAPPA CGB3
14	pulmonary valve insufficiency	30.5	REN PDE5A NPPB EDN1 CRP BMPR2
15	congenitally corrected transposition of the great arteries	30.4	TNNT2 NPPB
16	coronary stenosis	30.4	TNNI3 NPPB CRP ACE
17	libman-sacks endocarditis	30.4	F2 CRP
18	cardiac arrest	30.3	TNNT2 TNNI3 NPPB CRP ACE
19	lung abscess	30.3	GPT CRP ALB
20	peripheral artery disease	30.3	REN NPPB CRP ALB ACE
21	pulmonary disease, chronic obstructive	30.3	PDE5A NPPB CRP ALB ACE
22	inferior myocardial infarction	30.3	TNNT2 TNNI3 NPPB ACE
23	endocarditis	30.3	TNNT2 TNNI3 F2 CRP ALB
24	bronchopneumonia	30.3	GPT CRP ALB
25	orthostatic intolerance	30.2	REN MYH11 CRP ACE
26	protein-losing enteropathy	30.2	GPT F2 CRP ALB
27	amyloidosis, hereditary, transthyretin-related	30.2	TNNT2 NPPB ALB
28	nutritional deficiency disease	30.2	F2 CRP ALB
29	aortic valve disease 2	30.2	TNNT2 TNNI3 REN NPPB CRP ACE
30	immunoglobulin light chain amyloidosis	30.1	TNNT2 TNNI3 NPPB ALB
31	pleural empyema	30.1	GPT F2 CRP ALB
32	left ventricular noncompaction	30.1	TNNT2 TNNI3 PTPN11 ACE
33	polycythemia vera	30.1	PTPN11 F3 F2 CRP
34	thrombocytosis	30.1	F3 F2 CRP ALB
35	pericarditis	30.1	TNNT2 TNNI3 NPPB CRP ACE
36	beta-thalassemia	30.0	NPPB GPT F2 CRP
37	aortic dissection	30.0	TNNT2 MYH11 CRP ALB ACE
38	hemopneumothorax	30.0	GPT F3 F2 CRP
39	hemopericardium	30.0	TNNI3 NPPB F3 F2 CRP
40	transient cerebral ischemia	30.0	REN NPPB F3 F2 CRP ALB
41	hypersplenism	30.0	GPT F3 F2 ALB
42	restrictive cardiomyopathy	30.0	TNNT2 TNNI3 REN NR3C2 NPPB CRP
43	sleep disorder	30.0	REN EDN1 CRP ALB ACE
44	disseminated intravascular coagulation	30.0	GPT F3 F2 CRP
45	budd-chiari syndrome	30.0	GPT F3 F2 ALB
46	infective endocarditis	30.0	NPPB F3 F2 CRP ALB ACE
47	aortic disease	30.0	REN NPPB MYH11 CRP ALB ACE
48	pancytopenia	29.9	GPT F2 CRP ALB ACE
49	hepatopulmonary syndrome	29.9	EDN1 CRP BMPR2 ALB ACE
50	arteries, anomalies of	29.9	TNNI3 REN EDN1 CRP ALB ACE

Graphical network of the top 20 diseases related to Tricuspid Valve Insufficiency:

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Symptoms & Phenotypes for Tricuspid Valve Insufficiency

GenomeRNAi Phenotypes related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.18	ACE ALB BMPR2 CGB3 CRP EDN1
2	no effect	GR00402-S-2	10.18	ACE ALB BMPR2 CRP EDN1 F2

MGI Mouse Phenotypes related to Tricuspid Valve Insufficiency:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal	MP:0002873	10.07	ALB BMPR2 EDN1 F2 F3 PAPPA
2	muscle	MP:0005369	10.03	ALB BMPR2 EDN1 F2 F3 MYH11
3	homeostasis/metabolism	MP:0005376	10.03	ACE ALB BMPR2 CGB3 CRP EDN1
4	renal/urinary system	MP:0005367	9.92	ACE ALB BMPR2 EDN1 MC3R MYH11
5	growth/size/body region	MP:0005378	9.8	ACE BMPR2 CGB3 EDN1 F2 F3
6	cardiovascular system	MP:0005385	9.53	ACE ALB BMPR2 CRP EDN1 F2

Sources

Drugs & Therapeutics for Tricuspid Valve Insufficiency

Drugs for Tricuspid Valve Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Torasemide

Approved

Phase 4

56211-40-6

41781

2

Tolvaptan

Approved

Phase 4

150683-30-0

216237

3

Arginine Vasopressin

Phase 4

4

Vasopressins

Phase 4

5

Sodium Potassium Chloride Symporter Inhibitors

Phase 4

6

Bupivacaine

Approved, Investigational

Phase 3

2180-92-9, 38396-39-3

2474

7

Carvedilol

Approved, Investigational

Phase 3

72956-09-3

2585

8

Empagliflozin

Approved

Phase 3

864070-44-0

73151030 11949646

9

Kava

Approved, Investigational, Nutraceutical

Phase 2, Phase 3

9000-38-8

10

Anesthetics

Phase 3

11

Anesthetics, Local

Phase 3

12

Pharmaceutical Solutions

Phase 3

13

Hormones

Phase 3

14

Antihypertensive Agents

Phase 3

15

Neurotransmitter Agents

Phase 3

16

Adrenergic beta-Antagonists

Phase 3

17

Adrenergic Antagonists

Phase 3

18

Adrenergic alpha-Antagonists

Phase 3

19

Adrenergic alpha-1 Receptor Antagonists

Phase 3

20

Adrenergic Agents

Phase 3

21

Vasodilator Agents

Phase 3

22

Calcium, Dietary

Phase 3

23

Sodium-Glucose Transporter 2 Inhibitors

Phase 3

24

Hypoglycemic Agents

Phase 3

25

calcium channel blockers

Phase 3

26

Antioxidants

Phase 3

27

Protective Agents

Phase 3

28

Calcium

Nutraceutical

Phase 3

7440-70-2

271

29

Racepinephrine

Approved, Vet_approved

51-43-4, 329-65-7

838 5816

Synonyms:

(−)-(R)-epinephrine

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-BENZYL ALCOHOL

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-Adrenaline

(−)-ADRENALINE

(-)-Epinephrine

(+-)-Adrenaline

(+-)-Epinephrine

(R)-(-)-Adnephrine

(R)-(-)-Adrenaline

(R)-(−)-ADRENALINE

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-Adrenaline

(R)-Epinephrine

2-(Methylamino)-1-(3,4-dihydroxyphenyl)ethanol

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-HYDROXY-2-METHYLAMINOETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]PYROCATECHOL

Acetate, epinephrine

Adnephrine

ADREN CO

ADRENACLICK

Adrenal

Adrenalin

Adrenaline

Adrénaline

Adrenaline acid tartrate

Adrenaline bitartrate

Adrenaline hydrochloride

Adrenaline hydrochloride, racemic mixture

Adrenaline, racemic

Adrenaline, racemic mixture

adrenaline|epinephrine

Adrenine

Adrin

Allergan brand OF adrenaline hydrochloride

ANA-GUARD

Ana-kit

ANAPEN

ANAPHYLACTIC SHOCK DRUG KIT

ASMA-VYDRIN

ASTHMAHALER

Auvi-Q

Bird brand OF racepinefrine hydrochloride

Bosmin

Bronkaid mist

BROVON

Chelafrin

DL-Adrenaline

EMERADE

EPI E Z PEN JR

Epifrin

Epiglaufrin

Epinefrin

Epinefrina

Epinephran

Epinephrin

EPINEPHRINE

Epinephrine acetate

Epinephrine bitartrate

EPINEPHRINE HCL

Epinephrine hydrochloride

Epinephrine hydrochloride, racemic mixture

Epinephrine hydrogen tartrate

Epinephrine racemic

Epinephrine, racemic

Epinephrine, racemic mixture

Epinephrinum

Epipen

EPIPEN E Z PEN

Epipen JR

EPIPEN JR.

Epirenan

Epitrate

Eppy

Exadrin

Glauposine

GPPE INH SOLN

Hemisine

Hemostasin

Hemostatin

Hydrochloride, racepinephrine

Hypernephrin

Isoptoepinal

JEXT

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-Adrenaline

L-DETHYLAMINOETHANOLCATECHOL

L-Epinephrine

L-Epirenamine

Levoepinephrine

LEVO-METHYLAMINOETHANOLCATECHOL

Levorenen

Levorenin

Levorenine

Levoreninum

L-Methylaminoethanolcatechol

Lyodrin

Lyophrin

Medihaler-epi

Methylarterenol

Micronefrin

Micronephrine

Mixture adrenaline, racemic

Mixture epinephrine, racemic

Mucidrina

Nephridine

Nieraline

NSC-62786

Paranephrin

Primatene

Primatene mist

R-(-)-Epinephrine

Racemic adrenaline

Racemic epinephrine

Racemic mixture adrenaline

Racemic mixture epinephrine

Racepinefrina

Racepinefrine

Racepinefrinum

Racepinephrine

Racepinephrine hydrochloride

Renaglandin

Renaleptine

Renalina

Renoform

Renostypticin

Renostyptin

RIDDOBRON

RIDDOFAN

RYBARVIN

Scurenaline

Simplene

SOLN MADE TO RYBARVIN FOR

Styptirenal

Supracapsulin

Supranephrane

Suprarenaline

Suprarenin

Surrenine

Sus-phrine

SUS-PHRINE SULFITE FREE

SUS-PHRINE SULFITE-FREE

SYMJEPI

Takamina

TWINJECT

TWINJECT 0.15

TWINJECT 0.3

Vaponefrin

Vasoconstrictine

Vasotonin

30

Milrinone

Approved

78415-72-2

4197

31

Natriuretic Peptide, Brain

32

Epinephryl borate

33

Angiotensin Receptor Antagonists

34

diuretics

Interventional clinical trials:

(show top 50) (show all 116)

#	Name	Status	NCT ID	Phase	Drugs
1	The Safety and Efficacy of Tolvaptan for Patients With Tricuspid Regurgitation and Right Heart Failure After Left Heart Valves Replacement	Completed	NCT02644616	Phase 4	tolvaptan+torasemide;placebo+torasemide
2	Heterotopic Implantation Of the Edwards-Sapien Transcatheter Aortic Valve in the Inferior VEna Cava for the Treatment of Severe Tricuspid Regurgitation HOVER Trial	Completed	NCT02339974	Phase 4
3	The Effect of Cardiac Pacing Leads on Tricuspid Regurgitation	Completed	NCT01093001	Phase 4
4	Postoperative Analgesia After Cardiac Surgery - A Double-Blind, Prospective and Randomized Comparison of Wound Infiltration With Liposomal Bupivacaine and Bupivacaine Hydrochloride	Completed	NCT03270514	Phase 3	Exparel Injectable Product;Bupivacaine Hydrochloride
5	Multicenter, Randomized, 2 x 2 Factorial, Phase 3 Study to Assess the Efficacy of Carvedilol and Empagliflozin on Improvement of Right Ventricular Remodeling in Patients With Severe Functional Tricuspid Regurgitation	Recruiting	NCT04345796	Phase 3	Carvedilol+Empagliflozin;Carvedilol;Empagliflozin;Placebo
6	Treatment of Severe Secondary TRIcuspid Regurgitation in Patients With Advance Heart Failure With CAval Vein Implantation of the Edwards Sapien XT VALve	Terminated	NCT02387697	Phase 2, Phase 3
7	Percutaneous Treatment of Tricuspid Valve Regurgitation With the TriCinch System™	Completed	NCT02098200	Phase 1
8	Comparison Between Outcomes Of Ring And Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases	Unknown status	NCT02721524
9	Early Feasibility of the Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) for Symptomatic Chronic Functional Tricuspid Regurgitation	Unknown status	NCT02574650
10	The Impact of Right Ventricular Pacing on Tricuspid Regurgitation	Unknown status	NCT00419354
11	Left Ventricular Pacing to Prevent Iatrogenic Tricuspid Regurgitation Caused by Conventional Right Ventricular Pacing: a Pilot Study	Unknown status	NCT02314897
12	Cardiac Remodeling and Prognosis in Secondar Tricuspid Regurgitation	Unknown status	NCT03159923
13	Multi-centre Randomised Trial Investigating the Effect of PROphylactic triCuspID Annuloplasty in Patients With Dilated Tricuspid Annulus on Tricuspid Regurgitation Progression, Right Ventricular Remodeling and Functional Outcomes	Unknown status	NCT03129737
14	Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) for Symptomatic Chronic Functional Tricuspid Regurgitation	Unknown status	NCT03225612
15	Transcatheter Treatment of Severe Tricuspid Regurgitation Using the MitraClip System	Unknown status	NCT02863549
16	Echo-Guided Tricuspid Valve Surgery Vs. Conservative Approach At The Time Of Left- Sided Valve Surgery. A Prospective Randomized Study	Unknown status	NCT03278418
17	Long-term Outcome After Isolated Tricuspid Valve Repair	Unknown status	NCT01537458
18	Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart	Unknown status	NCT01444222
19	Prospective, Randomized Evaluation of Prophylactic Tricuspid Valve Annuloplasty in Patients Undergoing Mitral Valve Surgery	Unknown status	NCT01580436
20	Outcome of MC3 Ring Annuloplasty for Moderate and Severe Functional Tricuspid Regurgitation Associated With Rheumatic Mitral Valve Disease	Completed	NCT04078867
21	TRICUS STUDY - Safety and Efficacy of the TricValve® Transcatheter Bicaval Valves System in the Superior and Inferior Vena Cava in Patients With Severe Tricuspid Regurgitation.	Completed	NCT03723239
22	TRICUS STUDY EURO - Safety and Efficacy of the TricValve® Transcatheter Bicaval Valves System in the Superior and Inferior Vena Cava in Patients With Severe Tricuspid Regurgitation	Completed	NCT04141137
23	TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System	Completed	NCT02981953
24	Incidence of Residual Significant Tricuspid Regurgitation in Patients Undergoing Left-sided Cardiac Surgery	Completed	NCT04414358
25	Prevention of Pacemaker Lead Induced Tricuspid regurgitAtion by Transesophageal eCho guidEd Implantation Registry	Completed	NCT04945005
26	A Prospective Randomized Trial of Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Mitral Operation	Completed	NCT01246947
27	Prognostic Value of Early Postoperative Right Ventricular Systolic Function in Patients With Isolated Severe Tricuspid Regurgitation	Completed	NCT01203137
28	Biomarkers in Aortic Stenosis, Hypertrophic Cardiomyopathy, Mitral Regurgitation, Aortic Regurgitation, Prosthetic Heart Valve Dysfunction, and Tricuspid Regurgitation From Pacemaker Leads Study	Completed	NCT01334801
29	Evaluation of Mitral and Tricuspid Regurgitation: Cardiovascular Magnetic Resonance Imaging Versus Echocardiographic Doppler Color Flow Mapping of the Vena Contracta	Completed	NCT01504880
30	Prospective Registry of Patients With Isolated Severe Tricuspid Regurgitation	Completed	NCT01502462
31	Validation Study Comparing the Cardiac Output Pulmonary Arterial Catheter (Swan Ganz) to the FloWave™ 1000 Device	Completed	NCT00665301
32	Phonokardiographie Bei Erwachsenen	Completed	NCT03600051
33	Impact of Acute Normovolemic Hemodilution on Whole Blood Coagulation Profile During Post-cardiopulmonary Bypass in Cardiac Surgery: Rotational Thromboelastometry Study	Completed	NCT02502448		hydroxyethyl starch (HES 130/0.6)
34	Comparison of Rigid Annuloplasty Ring With a Band in the Correction of Secondary Tricuspid Insufficiency	Completed	NCT03144024
35	Does Acute Normovolemic Hemodilution Affect Intraoperative Value of Serum-creatinine Concentration in Patients Undergoing Cardiac Surgery?	Completed	NCT02831270		hydroxyethyl starch (HES 130/0.6)
36	Prophylactic Tricuspid Annuloplasty During Mitral Valve Surgery	Completed	NCT03604484
37	Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial	Completed	NCT01585779
38	EASE TRICUSPID Expertise-based Assessment Study on Clinical Efficacy of Contour 3D® in TRICUSPID Valve Annuloplasty	Completed	NCT01532921
39	The SPACER Trial - Repair of Tricuspid Valve Regurgitation Using the Edwards TricuSPid TrAnsCatheter REpaiR System	Completed	NCT02787408
40	The Institute of Cardiovascular Surgery	Completed	NCT01246141
41	Transcatheter Repair of Tricuspid Regurgitation With Cardioband TR System Post-Market Clinical Follow-Up Study (TriBAND): A European Prospective, Multicenter Post-market Clinical Follow-up Study to Assess Transcatheter Tricuspid Valve Repair With Edwards Cardioband TR System in Patients With Symptomatic Chronic Functional Tricuspid Regurgitation.	Recruiting	NCT03779490
42	Risk Stratification in Patients With Severe Tricuspid Regurgitation: Insights From the TRicuspid Regurgitation rEgistry (TRuE)	Recruiting	NCT04173091
43	Clinical and Echocardiographic Characteristics and Prognosis of trIcuspid regurgiTation (EPIT): Prospective and Retrospective Follow-up of a Cohort of Patients With Moderate or Severe Tricuspid Regurgitation	Recruiting	NCT03546231
44	Measurement of Tricuspid Regurgitation Volume for Assessment of Tricuspid Regurgitation Using 3D Transesophageal Echocardiography	Recruiting	NCT05130775
45	Minimally Invasive Tricuspid Surgery Versus Medical Treatment for Severe Tricuspid Regurgitation After Left-sided Valve Surgery	Recruiting	NCT04339192
46	Prospective, Single Arm, Multi-center, First-in-human (FIH) Study to Assess the Safety and Performance of the Innoventric Trillium™ Stent Graft for the Treatment of Severe Tricuspid Regurgitation (TR)	Recruiting	NCT04289870
47	Tricuspid Regurgitation Hamburg Cohort	Recruiting	NCT04755842
48	Transcatheter Repair of Tricuspid Regurgitation With Edwards PASCAL Transcatheter Valve Repair System: A European Prospective, Multicenter Post-Market Clinical Follow up	Recruiting	NCT04614402
49	Annuloplasty for the Treatment of Not-Severe Tricuspid Regurgitation in Patients Undergoing Surgery for Mitral Valve Disease: a Prospective, Spontaneous, Multicentre, Randomized Study	Recruiting	NCT02996552
50	Evaluation of the Safety, Efficacy and Cost-effectiveness of Transcatheter Tricuspid Valve Repair in Patients With Severe Tricuspid Regurgitation in the Netherlands	Recruiting	NCT05628779

Search NIH Clinical Center for Tricuspid Valve Insufficiency

Cochrane evidence based reviews: tricuspid valve insufficiency

Sources

Genetic Tests for Tricuspid Valve Insufficiency

Genetic tests related to Tricuspid Valve Insufficiency:

#	Genetic test	Affiliating Genes
1	Tricuspid Regurgitation ²⁸

Sources

Anatomical Context for Tricuspid Valve Insufficiency

Organs/tissues related to Tricuspid Valve Insufficiency:

MalaCards : Heart, Liver, Brain, Whole Blood, Lung, Atrioventricular Node, Kidney

Sources

Publications for Tricuspid Valve Insufficiency

Articles related to Tricuspid Valve Insufficiency:

(show top 50) (show all 7487)

#	Title	Authors	PMID	Year
1	A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data. ⁵	Szot JO...Dunwoodie SL	29555671	2018
2	Prenatal sonographic features of fetuses in trisomy 13 pregnancies. IV. ⁵³ ⁶²	Chen CP	20466286	2010
3	Clinical utility of B-type natriuretic peptide for estimating left ventricular filling pressures in unselected elderly patients undergoing diagnostic coronary angiography. ⁵³ ⁶²	Stolker JM...Rich MW	20197576	2010
4	Application of classic heart failure definitions of asymptomatic and symptomatic ventricular dysfunction and heart failure symptoms with preserved ejection fraction to patients with systemic right ventricles. ⁵³ ⁶²	Szymanski P...Hoffman P	19616677	2009
5	Elevated serum cobalamin in patients with decompensated biventricular failure. ⁵³ ⁶²	Zafarullah H...Weber KT	19011393	2008
6	Right heart dysfunction assessed with echography, B-type natriuretic peptide and cardiopulmonary test in patients with chronic heart failure. ⁵³ ⁶²	Troisi F...Di Biase M	18545065	2008
7	B-type natriuretic peptide in patients with systemic right ventricle. ⁵³ ⁶²	Koch AM...Singer H	17934262	2008
8	Assessment of factors affecting plasma BNP levels in patients with chronic atrial fibrillation and preserved left ventricular systolic function. ⁵³ ⁶²	Kim BJ...Park JR	16959341	2007
9	[The stady of pulmonary hypertension and plasma BNP values in respiratory diseases]. ⁵³ ⁶²	Yano S...Ikeda T	17228802	2006
10	Screening for trisomy 21 by fetal tricuspid regurgitation, nuchal translucency and maternal serum free beta-hCG and PAPP-A at 11 + 0 to 13 + 6 weeks. ⁵³ ⁶²	Falcon O...Nicolaides KH	16388509	2006
11	[Feasibility of cardiopulmonary rehabilitation in patients with idiopathic pulmonary arterial hypertension treated with intravenous prostacyclin infusion therapy]. ⁵³ ⁶²	Uchi M...Harada T	16320975	2005
12	Brain-type natriuretic peptide in the diagnosis and management of persistent pulmonary hypertension of the newborn. ⁵³ ⁶²	Reynolds EW...Bada HS	15520111	2004
13	Usefulness of B-type natriuretic peptide levels in predicting hemodynamic perturbations after heart transplantation despite preserved left ventricular systolic function. ⁵³ ⁶²	Park MH...Mehra MR	12480042	2002
14	A case of gastric antral vascular ectasia in which PuraStat, a novel self-assembling peptide hemostatic hydrogel, was effective. ⁶²	Misumi Y...Nonaka K	36381641	2023
15	Prognostic Value of Nonalcoholic Fatty Liver Disease in Patients With Severe Aortic Stenosis Who Underwent Transcatheter Aortic Valve Implantation. ⁶²	Nabeta T...Delgado V	36319504	2023
16	Guiding Interventions for Secondary Tricuspid Regurgitation: Follow the Intricate Interplay Between Form and Function. ⁶²	Alipour Symakani RS...Taverne YJHJ	34495894	2023
17	First Trimester Tricuspid Regurgitation: Clinical Significance. ⁶²	Teixeira S...Guedes-Martins L	36475342	2022
18	Anterior leaflet-oriented tricuspid annuloplasty using a flexible ring for severe tricuspid regurgitation. ⁶²	Kasegawa H...Shimokawa T	35107639	2022
19	Tricuspid leaflet kinematics after annular size reduction in ovine functional tricuspid regurgitation. ⁶²	Malinowski M...Timek TA	33685738	2022
20	Area of the right atrium of the fetal heart and its significance in fetuses with tricuspid regurgitation. ⁶²	Pavlicek J...Kacerovsky M	33478280	2022
21	Comparison of Residual Tricuspid Regurgitation Severity Assessed by Intraprocedural and Postprocedural Echocardiography in Patients Undergoing Transcatheter Tricuspid Valve Repair. ⁶²	Kuwajima K...Shiota T	36180287	2022
22	Unsupervised Machine Learning for Assessment of Left Ventricular Diastolic Function and Risk Stratification. ⁶²	Chao CJ...Pellikka PA	35840082	2022
23	Prognostic Impact of Indeterminate Diastolic Function in Patients with Functionally Insignificant Coronary Stenosis. ⁶²	Chung YJ...Lee JM	36470507	2022
24	Efficacy and Safety of Concomitant Tricuspid Repair in Patients Undergoing Mitral Valve Surgery: a Systematic Review and Meta-Analysis. ⁶²	Yasmin F...Aamir M	36007619	2022
25	Concomitant tricuspid valve repair in left ventricular assist device implantation may increase the risk for temporary right ventricular support but does not impact overall outcomes. ⁶²	Mihalj M...Reineke D	36469336	2022
26	Will clinical signs become myth? Developing structured Signs Circuits to improve medical students' exposure to and confidence examining clinical signs. ⁶²	Merriott D...Turton D	35388743	2022
27	Outcome of Pregnancy in Women With D-Transposition of the Great Arteries: A Systematic Review. ⁶²	Pizula J...Elkayam U	36444833	2022
28	Contemporary outcomes of the double switch operation for congenitally corrected transposition of the great arteries. ⁶²	Marathe SP...Baird CW	35688715	2022
29	No evidence of pulmonary hypertension revealed in an echographic evaluation of right-sided hemodynamics in hyperthyroid cats. ⁶²	Lachance L...Masseau I	36350661	2022
30	Safety and Efficacy of Sacubitril/Valsartan in Patients With a Failing Systemic Right Ventricle: A Prospective Single-Center Study. ⁶²	Fusco F...Sarubbi B	36458541	2022
31	Heterotopic Transcatheter Tricuspid Valve Replacement in a Patient With Carcinoid Heart Disease. ⁶²	Stolz L...Hausleiter J	36438434	2022
32	Estimation of Left Ventricular Filling Pressure Using Left Atrial Strain in Coarctation of Aorta. ⁶²	Egbe AC...Miranda WR	36328516	2022
33	Echocardiographic assessment and clinical implication of functional tricuspid regurgitation in heart failure with reduced or preserved ejection fraction (ECLIPSE-HF) : Rationale and design of the study. ⁶²	Ghio S...RIGHT-NET Investigators	36445668	2022
34	Tricuspid Regurgitation and Right Ventricular Function in Patients Undergoing Percutaneous Treatment of Mitral Regurgitation. ⁶²	Brunner S...Toggweiler S	36328515	2022
35	Critical care echocardiography in prone position patients during COVID-19 pandemic: a feasibility study. ⁶²	Ugalde D...Valenzuela ED	35229275	2022
36	Subsequent cardiac surgery after transcatheter aortic valve implantation: Indications and outcomes. ⁶²	Fagu A...Berger T	36378828	2022
37	Original technique for tricuspid valve replacement by mitral homograft: Step-by-step approach and initial results. ⁶²	Nuzhdin MD...Nadtochiy NB	36378863	2022
38	Severe Covid-19 and acute pulmonary hypertension: 24-month follow-up regarding mortality and relationship to initial echocardiographic findings and biomarkers. ⁶²	Norderfeldt J...Lonnqvist PA	36333823	2022
39	Prevalence and risk prediction value of tricuspid regurgitation by echocardiography in precapillary pulmonary hypertension. ⁶²	Li J...Zhai Z	36352385	2022
40	Risk of bleeding associated with transbronchial biopsy using flexible bronchoscopy in patients with echocardiographic or chest CT evidence of pulmonary hypertension. ⁶²	Takashima Y...Konno S	36443763	2022
41	Adaptive versus maladaptive right ventricular remodelling. ⁶²	Rako ZA...Tello K	36419369	2022
42	Echocardiographic changes after arteriovenous fistula creation in hemodialysis patients. ⁶²	Manzur-Pineda K...Duque JC	36168799	2022
43	Tricuspid valve detachment for ventricular septal defect closure: A meta-analysis of existing evidence. ⁶²	Yuan D...Qian Y	36378918	2022
44	Tricuspid regurgitation in His bundle pacing: A systematic review. ⁶²	Zaidi SMJ...Mehmoodi A	35763445	2022
45	Surgical approach to combined mitral and tricuspid valve disease: good neighbourhood rules. ⁶²	Ascione G...Alfieri O	36380807	2022
46	The hepato-cardiac disorders in Tibetan residents with hepatic echinococcosis: A case-control echocardiography study. ⁶²	Zhou M...Tan J	36353905	2022
47	Redo heart transplantation in a high-risk patient due to severe aortic regurgitation and accompanying right ventricular failure after LVAD implantation and temporary RVAD support. ⁶²	Arab MR...Zeriouh M	36321720	2022
48	Surgical edge-to-edge repair for tricuspid regurgitation: Impact of the concomitant annuloplasty. ⁶²	Lee H...Yoo JS	36455700	2022
49	Delay of surgical treatment of severe tricuspid regurgitation and outcomes in patients with left-sided heart valve disease. ⁶²	Carrascal Y...Velasco E	36427786	2022
50	Acquired left ventricular-right atrial communication after mitral valve replacement and tricuspid annuloplasty. ⁶²	Uwabe K...Furukawa H	36047411	2022

Sources

Genes for Tricuspid Valve Insufficiency

Genes related to Tricuspid Valve Insufficiency (1 elite genes):

(show all 26)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	403.03	Pathogenic ⁵ DISEASES inferred ¹⁴	29555671
2	MYH11	Myosin Heavy Chain 11	Protein Coding	29.04	Likely pathogenic ⁵ DISEASES inferred ¹⁴
3	NDE1	NudE Neurodevelopment Protein 1	Protein Coding	25	Likely pathogenic ⁵
4	NPPB	Natriuretic Peptide B	Protein Coding	14.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17934262 16320975 15520111 (more) 18545065 19616677 20197576 19011393 16959341 12480042 17228802
5	PAPPA	Pappalysin 1	Protein Coding	11.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	16388509 20466286
6	ACE	Angiotensin I Converting Enzyme	Protein Coding	7.61	DISEASES inferred ¹⁴
7	CRP	C-Reactive Protein	Protein Coding	7.38	DISEASES inferred ¹⁴
8	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	6.96	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	20466286 16388509
9	ALB	Albumin	Protein Coding	6.78	DISEASES inferred ¹⁴
10	TNNI3	Troponin I3, Cardiac Type	Protein Coding	6.73	DISEASES inferred ¹⁴
11	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	6.72	DISEASES inferred ¹⁴
12	PDE5A	Phosphodiesterase 5A	Protein Coding	6.71	DISEASES inferred ¹⁴
13	MC3R	Melanocortin 3 Receptor	Protein Coding	6.7	DISEASES inferred ¹⁴
14	REN	Renin	Protein Coding	6.63	DISEASES inferred ¹⁴
15	F2	Coagulation Factor II, Thrombin	Protein Coding	6.56	DISEASES inferred ¹⁴
16	EDN1	Endothelin 1	Protein Coding	6.47	DISEASES inferred ¹⁴
17	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	6.46	DISEASES inferred ¹⁴
18	F3	Coagulation Factor III, Tissue Factor	Protein Coding	6.46	DISEASES inferred ¹⁴
19	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	6.25	DISEASES inferred ¹⁴
20	TNNT2	Troponin T2, Cardiac Type	Protein Coding	5.99	DISEASES inferred ¹⁴
21	FBN1	Fibrillin 1	Protein Coding	5.81	DISEASES inferred ¹⁴
22	TNNT1	Troponin T1, Slow Skeletal Type	Protein Coding	5.81	DISEASES inferred ¹⁴
23	CLASRP	CLK4 Associating Serine/Arginine Rich Protein	Protein Coding	5.74	DISEASES inferred ¹⁴
24	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	5.72	DISEASES inferred ¹⁴
25	MME	Membrane Metalloendopeptidase	Protein Coding	5.71	DISEASES inferred ¹⁴
26	GALNT13	Polypeptide N-Acetylgalactosaminyltransferase 13	Protein Coding	5.67	DISEASES inferred ¹⁴

Sources

Variations for Tricuspid Valve Insufficiency

ClinVar genetic disease variations for Tricuspid Valve Insufficiency:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	PTPN11	NM_002834.5(PTPN11):c.184T>G (p.Tyr62Asp)	SNV	Pathogenic	13329	rs121918460	GRCh37: 12:112888168-112888168 GRCh38: 12:112450364-112450364
2	MYH11, NDE1	NM_002474.3(MYH11):c.4360G>C (p.Asp1454His)	SNV	Likely Pathogenic	374162	rs1057518938	GRCh37: 16:15818023-15818023 GRCh38: 16:15724166-15724166
3	GATA4	NM_001308093.3(GATA4):c.1276G>A (p.Asp426Asn)	SNV	Uncertain Significance	9034	rs56208331	GRCh37: 8:11615928-11615928 GRCh38: 8:11758419-11758419

Sources

Expression for Tricuspid Valve Insufficiency

Search GEO for disease gene expression data for Tricuspid Valve Insufficiency.

Sources

Pathways for Tricuspid Valve Insufficiency

Pathways related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.02	PTPN11 PDE5A NDE1 MYH11 MC3R F3
2	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	10.28	PTPN11 EDN1 CRP

Sources

GO Terms for Tricuspid Valve Insufficiency

Cellular components related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.68	REN PAPPA NPPB GPT F3 F2
2	cardiac myofibril	GO:0097512	9.46	TNNT2 TNNI3
3	cardiac Troponin complex	GO:1990584	9.26	TNNT2 TNNI3

Biological processes related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone-mediated signaling pathway	GO:0009755	9.85	REN PTPN11 CGB3
2	blood vessel diameter maintenance	GO:0097746	9.65	NPPB EDN1 ACE
3	vasoconstriction	GO:0042310	9.63	EDN1 CRP ACE
4	body fluid secretion	GO:0007589	9.62	NPPB EDN1
5	response to dexamethasone	GO:0071548	9.43	PAPPA EDN1 ACE
6	regulation of blood pressure	GO:0008217	9.28	REN NPPB MC3R EDN1 ACE

Molecular functions related to Tricuspid Valve Insufficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	troponin C binding	GO:0030172	8.92	TNNT2 TNNI3

Sources

Sources for Tricuspid Valve Insufficiency

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: TRC022 MIFTS: 49	Tricuspid Valve Insufficiency Categories: Blood diseases, Cardiovascular diseases	Data Licensing For inquiries, contact: [email protected]
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