MCID: TRC007
MIFTS: 30

Tricuspid Valve Prolapse

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Tricuspid Valve Prolapse

MalaCards integrated aliases for Tricuspid Valve Prolapse:

Name: Tricuspid Valve Prolapse 12 59 29 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5644
MeSH 44 D014263
Orphanet 59 ORPHA95458
MESH via Orphanet 45 D014263
UMLS via Orphanet 74 C0040962
ICD10 via Orphanet 34 Q22.8
UMLS 73 C0040962

Summaries for Tricuspid Valve Prolapse

MalaCards based summary : Tricuspid Valve Prolapse is related to tricuspid valve insufficiency and mid-dermal elastolysis. An important gene associated with Tricuspid Valve Prolapse is FBN1 (Fibrillin 1), and among its related pathways/superpathways are Elastic fibre formation and Regulation of Telomerase. Affiliated tissues include heart, kidney and liver, and related phenotypes are cardiovascular system and craniofacial

Related Diseases for Tricuspid Valve Prolapse

Graphical network of the top 20 diseases related to Tricuspid Valve Prolapse:



Diseases related to Tricuspid Valve Prolapse

Symptoms & Phenotypes for Tricuspid Valve Prolapse

MGI Mouse Phenotypes related to Tricuspid Valve Prolapse:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 FBLN5 FBN1 PHEX PIK3C2A SMAD3
2 craniofacial MP:0005382 9.46 FBLN5 FBN1 PHEX SMAD3
3 growth/size/body region MP:0005378 9.43 EGF FBLN5 FBN1 PHEX PIK3C2A SMAD3
4 renal/urinary system MP:0005367 8.92 FBN1 PHEX PIK3C2A SMAD3

Drugs & Therapeutics for Tricuspid Valve Prolapse

Search Clinical Trials , NIH Clinical Center for Tricuspid Valve Prolapse

Cochrane evidence based reviews: tricuspid valve prolapse

Genetic Tests for Tricuspid Valve Prolapse

Genetic tests related to Tricuspid Valve Prolapse:

# Genetic test Affiliating Genes
1 Tricuspid Valve Prolapse 29

Anatomical Context for Tricuspid Valve Prolapse

MalaCards organs/tissues related to Tricuspid Valve Prolapse:

41
Heart, Kidney, Liver

Publications for Tricuspid Valve Prolapse

Articles related to Tricuspid Valve Prolapse:

(show all 28)
# Title Authors Year
1
Two- and Three-dimensional Transthoracic Echocardiographic Assessment of Tricuspid Valve Prolapse with Mid-to-Late Systolic Tricuspid Regurgitation. ( 25903919 )
2015
2
Case images: tricuspid valve prolapse secondary to excessive long chordae evaluated by transthoracic echocardiography. ( 25620347 )
2014
3
Left ventricular assist device implantation induced tricuspid valve prolapse. ( 24255057 )
2013
4
Tricuspid valve prolapse associated with myxomatous degeneration. ( 7733736 )
1995
5
Transesophageal echocardiographic diagnosis of isolated tricuspid valve prolapse with severe tricuspid regurgitation. ( 1729835 )
1992
6
Gross tricuspid incompetence due to isolated tricuspid valve prolapse. ( 2262220 )
1990
7
Isolated tricuspid valve prolapse. ( 3370656 )
1988
8
Tricuspid valve prolapse. ( 3536107 )
1987
9
Isolated tricuspid valve prolapse diagnosed by echocardiography. ( 3946442 )
1986
10
Echocardiographic findings of mitral and tricuspid valve prolapse in primary pulmonary hypertension. ( 4019144 )
1985
11
Late systolic click from isolated tricuspid valve prolapse simulating paradoxical splitting of the second heart sound. ( 3973280 )
1985
12
Left ventricular outflow tract obstruction due to tricuspid valve prolapse through a high ventricular septal defect. ( 6190246 )
1983
13
Mitral and tricuspid valve prolapse in a patient with mixed connective tissue disease. ( 6857311 )
1983
14
High-speed echophonocardiograhic detection of tricuspid valve prolapse in mitral valve prolapse with discrepancy in onset of systolic murmur. ( 7055064 )
1982
15
Tricuspid valve prolapse: a common occurrence in the click-murmur syndrome. ( 6816829 )
1982
16
Detection of tricuspid valve prolapse. ( 7113910 )
1982
17
Precordial honk in association with tricuspid valve prolapse. ( 7054886 )
1982
18
Tricuspid valve prolapse diagnosed by cross-sectional echocardiography. ( 7460651 )
1981
19
Tricuspid valve prolapse: two-dimensional echocardiographic aspects. ( 6972137 )
1980
20
Two dimensional echocardiography in mitral, aortic and tricuspid valve prolapse. The clinical problem, cardiac nuclear imaging considerations and a proposed standard for diagnosis. ( 7006361 )
1980
21
[Tricuspid valve prolapse. Report of a case associated with Ebstein's anomaly (author's transl)]. ( 7461341 )
1980
22
Tricuspid valve prolapse. An echoacrdiographic diagnosis. ( 7380457 )
1980
23
Tricuspid regurgitation in tricuspid valve prolapse demonstrated with contrast cross-sectional echocardiography. ( 7446430 )
1980
24
Subxiphoid two-dimensional echocardiographic detection of tricuspid valve prolapse. ( 510009 )
1979
25
Occurrence and significance of echocardiographically demonstrated tricuspid valve prolapse. ( 676979 )
1978
26
Tricuspid valve prolapse diagnosed by echocardiogram. ( 1192864 )
1975
27
Echocardiographic detection of tricuspid valve prolapse. ( 1122585 )
1975
28
Tricuspid valve prolapse with late systolic tricuspid insufficiency. ( 4695894 )
1973

Variations for Tricuspid Valve Prolapse

Expression for Tricuspid Valve Prolapse

Search GEO for disease gene expression data for Tricuspid Valve Prolapse.

Pathways for Tricuspid Valve Prolapse

Pathways related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.12 FBLN5 FBN1
2 10.98 EGF SMAD3
3 10.72 EGF SMAD3
4 10.02 FBN1 SMAD3

GO Terms for Tricuspid Valve Prolapse

Biological processes related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of canonical Wnt signaling pathway GO:0090263 9.26 EGF SMAD3
2 cellular response to transforming growth factor beta stimulus GO:0071560 9.16 FBN1 SMAD3
3 epidermal growth factor receptor signaling pathway GO:0007173 8.96 EGF PIK3C2A
4 skeletal system development GO:0001501 8.8 FBN1 PHEX SMAD3

Molecular functions related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix constituent conferring elasticity GO:0030023 8.62 FBLN5 FBN1

Sources for Tricuspid Valve Prolapse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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