MCID: TRC007
MIFTS: 35

Tricuspid Valve Prolapse

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Prolapse

MalaCards integrated aliases for Tricuspid Valve Prolapse:

Name: Tricuspid Valve Prolapse 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5644
MeSH 44 D014263
SNOMED-CT 67 253383003
UMLS 70 C0040962

Summaries for Tricuspid Valve Prolapse

MalaCards based summary : Tricuspid Valve Prolapse is related to ventricular septal defect and orthostatic intolerance. An important gene associated with Tricuspid Valve Prolapse is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. Affiliated tissues include heart, lung and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Tricuspid Valve Prolapse

Diseases related to Tricuspid Valve Prolapse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 ventricular septal defect 29.9 TGFBR2 FLNA FBN2
2 orthostatic intolerance 29.4 TGFBR2 TGFBR1 TGFB2 SLC2A10 FLNA FBN2
3 connective tissue disease 28.4 TGFBR2 TGFBR1 TGFB2 FLNA FBN2 FBN1
4 tricuspid valve insufficiency 10.5
5 heart septal defect 10.3
6 ectopia lentis 1, isolated, autosomal dominant 10.3 TGFBR2 FBN1
7 transient hypogammaglobulinemia of infancy 10.2 TGFBR2 TGFBR1
8 transient hypogammaglobulinemia 10.2 TGFBR2 TGFBR1
9 ectopia lentis 2, isolated, autosomal recessive 10.2 TGFBR2 FBN1
10 marden-walker syndrome 10.2 FBN2 FBN1
11 postural orthostatic tachycardia syndrome 10.2 FBN2 FBN1
12 atrioventricular block 10.2
13 infective endocarditis 10.2
14 mitral valve insufficiency 10.2
15 atrial heart septal defect 10.2
16 mid-dermal elastolysis 10.2 FBN1 FBLN5
17 multiple self-healing squamous epithelioma 10.2 TGFBR2 TGFBR1
18 familial abdominal aortic aneurysm 10.2 FBN1 COL3A1
19 subclavian artery aneurysm 10.2 TGFBR2 SLC2A10 FBN1
20 cleft soft palate 10.2 TGFBR2 SLC2A10
21 acromicric dysplasia 10.1 FBN2 FBN1
22 tendinosis 10.1 TGFBR2 TGFB2
23 mitochondrial dna depletion syndrome 12b 10.1 TGFBR2 TGFBR1 FBN1
24 aortic aneurysm, familial thoracic 6 10.1 TGFBR1 SLC2A10 FBN1
25 loeys-dietz syndrome 2 10.1 TGFBR2 TGFBR1 FBN1
26 enophthalmos 10.1 FBN2 FBN1
27 tuberculoid leprosy 10.1 TGFB3 TGFB2
28 stiff skin syndrome 10.1 TGFB2 FBN2 FBN1
29 pulmonary hypertension 10.0
30 dextro-looped transposition of the great arteries 10.0
31 endocarditis 10.0
32 hypertrophic cardiomyopathy 10.0
33 mixed connective tissue disease 10.0
34 aortic valve prolapse 10.0
35 lung disease 10.0
36 congenitally corrected transposition of the great arteries 10.0
37 double discordia 10.0
38 atrial septal aneurysm 10.0
39 bullous keratopathy 10.0 TGFB3 TGFB2 FBN1
40 camurati-engelmann disease 10.0 TGFBR2 TGFBR1
41 keratopathy 10.0 TGFB3 TGFB2 FBN1
42 keloid formation 10.0 TGFBR1 FLNA
43 tracheal disease 10.0 FLNA FBN1
44 peyronie's disease 10.0 TGFB3 TGFB2
45 hereditary hemorrhagic telangiectasia 10.0 TGFBR2 TGFBR1 TGFB2
46 pulsating exophthalmos 10.0 TGFBR2 TGFBR1 COL3A1
47 phacogenic glaucoma 10.0 TGFB2 FBN1 FBLN5
48 high-grade astrocytoma 10.0 TGFB2 FLNA
49 meester-loeys syndrome 10.0 SLC2A10 EFEMP2
50 craniosynostosis 10.0 TGFBR2 TGFBR1 FBN1

Graphical network of the top 20 diseases related to Tricuspid Valve Prolapse:



Diseases related to Tricuspid Valve Prolapse

Symptoms & Phenotypes for Tricuspid Valve Prolapse

GenomeRNAi Phenotypes related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 10.02 TGFBR2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 10.02 CHST14
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 10.02 CHST14
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-121 10.02 TGFBR2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-123 10.02 TGFBR2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 10.02 CHST14
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.02 CHST14
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 10.02 TGFBR2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 10.02 TGFBR2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.02 TGFBR2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 10.02 TGFBR2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 10.02 CHST14 TGFBR1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 10.02 TGFBR1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 10.02 TGFBR2
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-214 10.02 TGFBR2
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-36 10.02 TGFBR1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 10.02 CHST14
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 10.02 TGFBR2
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 10.02 CHST14 TGFBR2
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 10.02 TGFBR2
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 10.02 TGFBR2
22 Decreased viability with paclitaxel GR00207-A-2 8.62 FBLN5 TGFB3

MGI Mouse Phenotypes related to Tricuspid Valve Prolapse:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.31 CHST14 COL3A1 EFEMP2 FBLN5 FBN1 FBN2
2 cellular MP:0005384 10.26 CHST14 COL3A1 EFEMP2 FBLN5 FBN1 FBN2
3 growth/size/body region MP:0005378 10.22 CHST14 COL3A1 EFEMP2 FBLN5 FBN1 FBN2
4 homeostasis/metabolism MP:0005376 10.16 CHST14 COL3A1 FBLN5 FBN1 FBN2 FLNA
5 craniofacial MP:0005382 10.11 CHST14 FBLN5 FBN1 FBN2 FLNA TGFB2
6 immune system MP:0005387 10.03 COL3A1 FBN1 FLNA SLC2A10 TGFB2 TGFB3
7 mortality/aging MP:0010768 10.02 CHST14 COL3A1 EFEMP2 FBN1 FBN2 FLNA
8 integument MP:0010771 10.01 CHST14 COL3A1 EFEMP2 FBLN5 FBN1 FBN2
9 digestive/alimentary MP:0005381 9.97 COL3A1 FLNA TGFB2 TGFB3 TGFBR1 TGFBR2
10 muscle MP:0005369 9.86 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 TGFB2
11 limbs/digits/tail MP:0005371 9.85 CHST14 EFEMP2 FBN1 FBN2 TGFB2 TGFB3
12 respiratory system MP:0005388 9.7 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 FLNA
13 renal/urinary system MP:0005367 9.63 CHST14 FBN1 FBN2 SLC2A10 TGFB2 TGFBR2
14 skeleton MP:0005390 9.28 CHST14 EFEMP2 FBN1 FBN2 FLNA TGFB2

Drugs & Therapeutics for Tricuspid Valve Prolapse

Search Clinical Trials , NIH Clinical Center for Tricuspid Valve Prolapse

Cochrane evidence based reviews: tricuspid valve prolapse

Genetic Tests for Tricuspid Valve Prolapse

Anatomical Context for Tricuspid Valve Prolapse

MalaCards organs/tissues related to Tricuspid Valve Prolapse:

40
Heart, Lung, Skin, Thyroid

Publications for Tricuspid Valve Prolapse

Articles related to Tricuspid Valve Prolapse:

(show top 50) (show all 121)
# Title Authors PMID Year
1
[Ruptured chordae tendineae of tricuspid valve in neonate with intractable persistent pulmonary hypertension: a case report and literature review]. 61
33775048 2021
2
Characteristics and Significance of Tricuspid Valve Prolapse in a Large Multidecade Echocardiographic Study. 61
33071045 2021
3
Transcatheter edge-to-edge repair for tricuspid regurgitation in Barlow-type tricuspid valve prolapse. 61
32077927 2020
4
Genotype-Phenotype Correlation in Children: The Impact of FBN1 Variants on Pediatric Marfan Care. 61
32679894 2020
5
A rare case report: tricuspid valve prolapse due to spontaneous chordae rupture in a congenitally corrected transposition of the great arteries patient. 61
32600335 2020
6
Three-Dimensional Echocardiography Reveals Extensive Congenital Anterior Tricuspid Valve Prolapse. 61
32577591 2020
7
Features of Marfan syndrome not listed in the Ghent nosology - the dark side of the disease. 61
31829751 2019
8
Infrequent concomitant mitral, pulmonary, and tricuspid valve prolapse associated with right ventricular failure: Correct diagnosis using multimodality imaging. 61
31475958 2019
9
Heart failure and sudden cardiac death in heritable thoracic aortic disease caused by pathogenic variants in the SMAD3 gene. 61
29717556 2018
10
Infantile Marfan syndrome in a Korean tertiary referral center. 61
26958064 2016
11
Two- and Three-dimensional Transthoracic Echocardiographic Assessment of Tricuspid Valve Prolapse with Mid-to-Late Systolic Tricuspid Regurgitation. 61
25903919 2015
12
[Characteristics of risk factors in young and middle-aged patients with first hemispheric ischemic stroke]. 61
26978634 2015
13
Case images: tricuspid valve prolapse secondary to excessive long chordae evaluated by transthoracic echocardiography. 61
25620347 2014
14
Cutis laxa with pulmonary emphysema, conjunctivochalasis, nasolacrimal duct obstruction, abnormal hair, and a novel FBLN5 mutation. 61
24962763 2014
15
Left ventricular assist device implantation induced tricuspid valve prolapse. 61
24255057 2013
16
FBN1 gene mutation characteristics and clinical features for the prediction of mitral valve disease progression. 61
23176764 2013
17
Impact of age and gender on cardiac pathology in children and adolescents with Marfan syndrome. 61
23183959 2013
18
Robot-assisted repair of tricuspid leaflet prolapse using standard valvuloplasty techniques. 61
23409356 2012
19
Pectus excavatum: echocardiography and cardiac MRI reveal frequent pericardial effusion and right-sided heart anomalies. 61
22298154 2012
20
[Immunological characteristics in subjects with heart connective tissue dysplasia depending on thyroid hormone levels and vegetative dysfunction]. 61
23285764 2012
21
Tricuspid valve repair with artificial chordae in a 72-year-old woman. 61
21425060 2011
22
Echocardiographic findings in children with Marfan syndrome. 61
21161115 2011
23
Isolated tricuspid valve prolapsed: identification using two- and three-dimensional echocardiography and transoesophageal echocardiography. 61
21709929 2011
24
Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome. 61
20854973 2010
25
Flail mitral and tricuspid valves due to myxomatous disease. 61
17197244 2008
26
[Congenital tricuspid valve prolapse with severe regurgitation in one child]. 61
18289485 2008
27
Echocardiographic and clinical abnormalities in patients with psoriasis. 61
17294995 2006
28
Clinical correlates and mortality of hemodynamically significant tricuspid regurgitation. 61
15473480 2004
29
[Marfan syndrome in the newborn and infants less than 4 months: a series of 9 patients]. 61
12085746 2002
30
Marfan Syndrome 61
20301510 2001
31
[Acromegaly associated with mitral and tricuspid prolapse. Report of a case]. 61
10956612 2000
32
Relation between QT dispersion and ventricular arrhythmias in uncomplicated isolated mitral valve prolapse. 61
10614836 1999
33
Mimics of Ebstein's anomaly. 61
9327709 1997
34
Echocardiographic Changes in Cases of Intermittent Acute Porphyria. 61
11174947 1997
35
Abnormal ambulatory electrocardiographic findings in patients with the Marfan syndrome. 61
9104435 1997
36
Clinical and echocardiographic features of mitral valve prolapse patients in a local population. 61
8942249 1996
37
[Tricuspid valve prolapse]. 61
9117653 1996
38
Physiological valvular regurgitation in clinically normal young racehorses: prevalence and two-dimensional colour flow Doppler echocardiographic characteristics. 61
8933070 1995
39
Bivalvular endocarditis complicating pregnancy. A case report and literature review. 61
7741329 1995
40
Tricuspid valve prolapse associated with myxomatous degeneration. 61
7733736 1995
41
[Value of transesophageal echocardiography in the assessment of blunt chest trauma: correlation with electrocardiogram, heart enzymes, and transthoracic echocardiogram]. 61
7848654 1994
42
Valvular heart disease: the influence of changing etiology on nosology. 61
8000586 1994
43
[Multiple heart valve involvement in renal polycystic disease in the adult]. 61
8066312 1994
44
[Doppler echocardiography in endomyocardial fibrosis]. 61
7979815 1994
45
Development of valve dysfunction in adolescents and young adults with Down syndrome and no known congenital heart disease. 61
8496770 1993
46
[Cardiovascular manifestations of hereditary dysplasias of connective tissue]. 61
8517593 1993
47
[Atrial septal aneurysm and associated anomalies. Personal experience with 38 cases]. 61
8510815 1993
48
[Pathology and histochemistry of mitral valve prolapse]. 61
8164136 1993
49
Transesophageal echocardiography: normal variants and mimickers. 61
1341889 1992
50
[Marfan syndrome in childhood: cardiovascular manifestations. Echocardiographic changes]. 61
1416516 1992

Variations for Tricuspid Valve Prolapse

Expression for Tricuspid Valve Prolapse

Search GEO for disease gene expression data for Tricuspid Valve Prolapse.

Pathways for Tricuspid Valve Prolapse

Pathways related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 TGFBR2 TGFBR1 TGFB3 TGFB2 FLNA FBN2
2
Show member pathways
13.22 TGFBR2 TGFBR1 TGFB3 TGFB2 FBN2 FBN1
3
Show member pathways
13.17 TGFBR2 TGFBR1 TGFB3 TGFB2 SLC2A10 FLNA
4
Show member pathways
12.9 TGFBR1 TGFB3 TGFB2 FBN2 FBN1 EFEMP2
5
Show member pathways
12.72 TGFBR2 TGFBR1 TGFB3 TGFB2
6 12.7 TGFBR2 TGFBR1 TGFB3 TGFB2
7 12.67 TGFBR2 TGFBR1 TGFB3 TGFB2 FLNA
8
Show member pathways
12.66 TGFBR2 TGFBR1 TGFB3 TGFB2
9
Show member pathways
12.63 TGFBR2 TGFBR1 TGFB3 TGFB2
10
Show member pathways
12.49 TGFBR2 TGFBR1 TGFB3 TGFB2
11
Show member pathways
12.45 TGFB3 TGFB2 FBN2 FBN1 FBLN5 EFEMP2
12
Show member pathways
12.38 TGFBR2 TGFBR1 TGFB3 TGFB2
13 12.26 TGFBR2 TGFBR1 TGFB3 TGFB2
14 12.12 TGFBR2 TGFBR1 TGFB3 TGFB2
15 12.11 TGFBR1 TGFB3 TGFB2
16 12.09 TGFBR2 TGFBR1 TGFB3 TGFB2
17 12.08 TGFBR2 TGFBR1 TGFB3 TGFB2
18
Show member pathways
12.01 TGFBR2 TGFBR1 TGFB3 TGFB2
19 12 TGFBR2 TGFB2 SLC2A10
20
Show member pathways
11.86 TGFBR2 TGFBR1 TGFB2
21 11.83 TGFB3 TGFB2 COL3A1
22 11.82 TGFBR2 TGFBR1 TGFB3 TGFB2
23 11.77 TGFBR2 TGFBR1 TGFB3 TGFB2 COL3A1
24 11.76 TGFBR1 TGFB3 TGFB2
25
Show member pathways
11.75 TGFBR2 TGFBR1 TGFB3 TGFB2
26 11.69 TGFBR2 TGFBR1 TGFB3 TGFB2 FBN1
27 11.56 TGFBR2 TGFBR1 TGFB3 TGFB2 FLNA
28
Show member pathways
11.54 TGFBR2 TGFBR1 TGFB3 TGFB2
29 11.5 TGFBR2 TGFBR1 TGFB3
30 11.48 TGFBR2 TGFBR1 TGFB2
31 11.18 TGFBR2 TGFBR1 TGFB3 TGFB2
32
Show member pathways
11.17 TGFBR2 TGFBR1 TGFB3
33 11.15 TGFBR2 TGFBR1 TGFB3
34 10.98 TGFBR2 TGFBR1
35
Show member pathways
10.96 TGFB3 TGFB2 FBN2 FBN1 FBLN5 EFEMP2
36 10.89 TGFB3 TGFB2 FBN2 FBN1 EFEMP2 COL3A1
37 10.75 TGFBR2 TGFBR1 FLNA FBN2 FBN1
38 10.73 TGFB3 TGFB2
39 10.69 TGFBR2 TGFBR1 TGFB3 TGFB2

GO Terms for Tricuspid Valve Prolapse

Cellular components related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.92 TGFB3 TGFB2 FLNA FBN2 FBN1 FBLN5
2 extracellular space GO:0005615 9.85 TGFB3 TGFB2 FBN1 FBLN5 EFEMP2 COL3A1
3 extracellular matrix GO:0031012 9.55 FBN2 FBN1 FBLN5 EFEMP2 COL3A1
4 elastic fiber GO:0071953 9.26 FBLN5 EFEMP2
5 collagen-containing extracellular matrix GO:0062023 9.17 TGFB3 TGFB2 FBN2 FBN1 FBLN5 EFEMP2
6 microfibril GO:0001527 9.13 FBN2 FBN1 EFEMP2

Biological processes related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 TGFBR2 TGFBR1 TGFB3 TGFB2
2 extracellular matrix organization GO:0030198 9.89 FBN2 FBN1 FBLN5 COL3A1
3 in utero embryonic development GO:0001701 9.86 TGFBR2 TGFBR1 TGFB3
4 regulation of cell proliferation GO:0042127 9.86 TGFBR2 TGFB3 TGFB2
5 response to hypoxia GO:0001666 9.84 TGFBR2 TGFB3 TGFB2
6 kidney development GO:0001822 9.83 TGFBR1 TGFB2 FBN1
7 platelet degranulation GO:0002576 9.82 TGFB3 TGFB2 FLNA
8 skeletal system development GO:0001501 9.8 TGFBR1 TGFB2 FBN1 COL3A1
9 heart development GO:0007507 9.8 TGFBR2 TGFBR1 TGFB2 FBN1 COL3A1
10 collagen fibril organization GO:0030199 9.75 TGFBR1 TGFB2 COL3A1
11 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.73 TGFBR2 TGFBR1 TGFB3 SLC2A10
12 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.72 TGFBR1 TGFB3 TGFB2
13 epithelial to mesenchymal transition GO:0001837 9.71 TGFBR1 TGFB2 FLNA
14 odontogenesis GO:0042476 9.69 TGFB3 TGFB2
15 ventricular septum morphogenesis GO:0060412 9.69 TGFBR2 TGFBR1 TGFB2
16 embryonic cranial skeleton morphogenesis GO:0048701 9.68 TGFBR2 TGFBR1
17 digestive tract development GO:0048565 9.68 TGFBR2 TGFB3
18 positive regulation of filopodium assembly GO:0051491 9.67 TGFBR1 TGFB3
19 protein localization to cell surface GO:0034394 9.67 FLNA FBLN5
20 outflow tract septum morphogenesis GO:0003148 9.67 TGFBR2 TGFB2
21 activin receptor signaling pathway GO:0032924 9.66 TGFBR2 TGFBR1
22 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.65 TGFBR2 TGFBR1
23 positive regulation of SMAD protein signal transduction GO:0060391 9.65 TGFBR1 TGFB3
24 cardiac epithelial to mesenchymal transition GO:0060317 9.64 TGFBR1 TGFB2
25 ventricular trabecula myocardium morphogenesis GO:0003222 9.63 TGFBR1 TGFB2
26 atrioventricular valve morphogenesis GO:0003181 9.63 TGFBR2 TGFB2
27 cell-cell junction organization GO:0045216 9.63 TGFB3 TGFB2 FLNA
28 response to cholesterol GO:0070723 9.62 TGFBR2 TGFBR1
29 elastic fiber assembly GO:0048251 9.62 FBLN5 EFEMP2
30 embryonic eye morphogenesis GO:0048048 9.61 FBN2 FBN1
31 salivary gland morphogenesis GO:0007435 9.61 TGFB3 TGFB2
32 membranous septum morphogenesis GO:0003149 9.6 TGFBR2 TGFB2
33 negative regulation of macrophage cytokine production GO:0010936 9.58 TGFB3 TGFB2
34 sequestering of TGFbeta in extracellular matrix GO:0035583 9.57 FBN2 FBN1
35 endocardial cushion fusion GO:0003274 9.56 TGFBR2 TGFB2
36 positive regulation of epithelial to mesenchymal transition GO:0010718 9.56 TGFBR2 TGFBR1 TGFB3 TGFB2
37 secondary palate development GO:0062009 9.54 TGFBR2 TGFB3 TGFB2
38 positive regulation of tight junction disassembly GO:1905075 9.52 TGFBR1 TGFB3
39 pathway-restricted SMAD protein phosphorylation GO:0060389 9.5 TGFBR2 TGFBR1 TGFB2
40 uterine wall breakdown GO:0042704 9.48 TGFB3 TGFB2
41 transforming growth factor beta receptor signaling pathway GO:0007179 9.35 TGFBR2 TGFBR1 TGFB3 TGFB2 COL3A1
42 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.33 TGFBR2 TGFBR1 TGFB2
43 wound healing GO:0042060 9.02 TGFBR2 TGFBR1 TGFB3 TGFB2 COL3A1

Molecular functions related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.69 FBN1 FBLN5 COL3A1
2 extracellular matrix structural constituent GO:0005201 9.62 FBN2 FBN1 EFEMP2 COL3A1
3 SMAD binding GO:0046332 9.54 TGFBR2 TGFBR1 FLNA
4 transforming growth factor beta receptor binding GO:0005160 9.49 TGFB3 TGFB2
5 activin binding GO:0048185 9.48 TGFBR2 TGFBR1
6 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.46 TGFBR2 TGFBR1
7 type I transforming growth factor beta receptor binding GO:0034713 9.43 TGFBR2 TGFB3
8 transforming growth factor beta binding GO:0050431 9.43 TGFBR2 TGFBR1 TGFB3
9 transforming growth factor beta-activated receptor activity GO:0005024 9.4 TGFBR2 TGFBR1
10 extracellular matrix constituent conferring elasticity GO:0030023 9.33 FBN2 FBN1 FBLN5
11 type II transforming growth factor beta receptor binding GO:0005114 9.13 TGFBR1 TGFB3 TGFB2
12 type III transforming growth factor beta receptor binding GO:0034714 8.8 TGFBR2 TGFB3 TGFB2

Sources for Tricuspid Valve Prolapse

3 CDC
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11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
36 KEGG
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
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54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
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69 Tocris
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71 UMLS via Orphanet
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