MCID: TRC007
MIFTS: 36

Tricuspid Valve Prolapse

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Tricuspid Valve Prolapse

MalaCards integrated aliases for Tricuspid Valve Prolapse:

Name: Tricuspid Valve Prolapse 12 58 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5644
MeSH 43 D014263
SNOMED-CT 67 253383003
MESH via Orphanet 44 D014263
ICD10 via Orphanet 33 Q22.8
UMLS via Orphanet 72 C0040962
Orphanet 58 ORPHA95458
UMLS 71 C0040962

Summaries for Tricuspid Valve Prolapse

MalaCards based summary : Tricuspid Valve Prolapse is related to orthostatic intolerance and connective tissue disease. An important gene associated with Tricuspid Valve Prolapse is FBN1 (Fibrillin 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. Affiliated tissues include heart, kidney and thyroid, and related phenotypes are Decreased viability with paclitaxel and cardiovascular system

Related Diseases for Tricuspid Valve Prolapse

Diseases related to Tricuspid Valve Prolapse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 27.4 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
2 connective tissue disease 27.3 TGFBR2 TGFBR1 TGFB2 SMAD3 FBN2 FBN1
3 tricuspid valve insufficiency 10.5
4 ectopia lentis 1, isolated, autosomal dominant 10.3 TGFBR2 FBN1
5 ectopia lentis 2, isolated, autosomal recessive 10.3 TGFBR2 FBN1
6 heart septal defect 10.3
7 transient hypogammaglobulinemia of infancy 10.3 TGFBR2 TGFBR1
8 transient hypogammaglobulinemia 10.3 TGFBR2 TGFBR1
9 marden-walker syndrome 10.3 FBN2 FBN1
10 aortic aneurysm, familial thoracic 6 10.3 TGFBR1 SLC2A10
11 eisenmenger syndrome 10.3 TGFBR2 TGFBR1
12 postural orthostatic tachycardia syndrome 10.3 FBN2 FBN1
13 multiple self-healing squamous epithelioma 10.2 TGFBR2 TGFBR1
14 juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome 10.2 TGFBR2 TGFBR1
15 atrioventricular block 10.2
16 infective endocarditis 10.2
17 endocarditis 10.2
18 atrial heart septal defect 10.2
19 tracheal stenosis 10.2 TGFB3 FBN1
20 acromicric dysplasia 10.2 FBN2 FBN1
21 mid-dermal elastolysis 10.2 FBN1 FBLN5
22 tendinosis 10.2 TGFBR2 TGFB2
23 patent ductus arteriosus 1 10.1 TGFBR2 TGFBR1 FBN1
24 isolated ectopia lentis 10.1 FBN2 FBN1
25 melnick-needles syndrome 10.1
26 pulmonary hypertension 10.1
27 mitral valve insufficiency 10.1
28 hypertrophic cardiomyopathy 10.1
29 ventricular septal defect 10.1
30 mixed connective tissue disease 10.1
31 aortic valve prolapse 10.1
32 lung disease 10.1
33 atrial septal aneurysm 10.1
34 tuberculoid leprosy 10.1 TGFB3 TGFB2
35 stiff skin syndrome 10.1 TGFB2 FBN2 FBN1
36 autosomal recessive cutis laxa type iii 10.0 FBLN5 EFEMP2
37 cutis laxa, autosomal recessive, type ib 10.0 FBLN5 EFEMP2
38 cutis laxa, autosomal recessive, type iia 10.0 FBLN5 EFEMP2
39 bullous keratopathy 10.0 TGFB3 TGFB2 FBN1
40 keratopathy 10.0 TGFB3 TGFB2 FBN1
41 mitral valve disease 10.0 TGFB3 TGFB2 FBN1
42 cutis laxa, autosomal recessive, type ic 10.0 FBLN5 EFEMP2
43 hereditary hemorrhagic telangiectasia 10.0 TGFBR2 TGFBR1 TGFB2
44 cutis laxa, autosomal recessive, type iib 10.0 FBLN5 EFEMP2
45 familial abdominal aortic aneurysm 10.0 FBN1 COL3A1
46 hypertrophic scars 9.9 TGFB3 SMAD3
47 camurati-engelmann disease 9.9 TGFBR2 TGFBR1
48 phacogenic glaucoma 9.9 TGFB2 FBN1 FBLN5
49 cutis laxa 9.9 FBN1 FBLN5 EFEMP2
50 ureteric orifice cancer 9.9 FBN1 FBLN5 EFEMP2

Graphical network of the top 20 diseases related to Tricuspid Valve Prolapse:



Diseases related to Tricuspid Valve Prolapse

Symptoms & Phenotypes for Tricuspid Valve Prolapse

GenomeRNAi Phenotypes related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00207-A-2 8.62 FBLN5 TGFB3

MGI Mouse Phenotypes related to Tricuspid Valve Prolapse:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.28 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 SLC2A10
2 cellular MP:0005384 10.22 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 SMAD3
3 hematopoietic system MP:0005397 10.16 COL3A1 FBN1 FBN2 PDLIM1 SLC2A10 SMAD3
4 growth/size/body region MP:0005378 10.13 COL3A1 FBLN5 FBN1 FBN2 SMAD3 TGFB2
5 homeostasis/metabolism MP:0005376 10.13 COL3A1 FBLN5 FBN1 FBN2 PDLIM1 SMAD3
6 immune system MP:0005387 10.1 COL3A1 FBN1 FBN2 PDLIM1 SLC2A10 SMAD3
7 craniofacial MP:0005382 10.05 FBLN5 FBN1 FBN2 SMAD3 TGFB2 TGFB3
8 digestive/alimentary MP:0005381 9.97 COL3A1 SMAD3 TGFB2 TGFB3 TGFBR1 TGFBR2
9 integument MP:0010771 9.97 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 SMAD3
10 muscle MP:0005369 9.86 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 TGFB2
11 limbs/digits/tail MP:0005371 9.8 EFEMP2 FBN1 FBN2 SMAD3 TGFB2 TGFB3
12 respiratory system MP:0005388 9.65 COL3A1 EFEMP2 FBLN5 FBN1 FBN2 SLC2A10
13 renal/urinary system MP:0005367 9.63 FBN1 FBN2 SLC2A10 SMAD3 TGFB2 TGFBR2
14 skeleton MP:0005390 9.23 EFEMP2 FBN1 FBN2 SMAD3 TGFB2 TGFB3

Drugs & Therapeutics for Tricuspid Valve Prolapse

Search Clinical Trials , NIH Clinical Center for Tricuspid Valve Prolapse

Cochrane evidence based reviews: tricuspid valve prolapse

Genetic Tests for Tricuspid Valve Prolapse

Anatomical Context for Tricuspid Valve Prolapse

MalaCards organs/tissues related to Tricuspid Valve Prolapse:

40
Heart, Kidney, Thyroid

Publications for Tricuspid Valve Prolapse

Articles related to Tricuspid Valve Prolapse:

(show top 50) (show all 117)
# Title Authors PMID Year
1
Three-Dimensional Echocardiography Reveals Extensive Congenital Anterior Tricuspid Valve Prolapse. 61
32577591 2020
2
Transcatheter edge-to-edge repair for tricuspid regurgitation in Barlow-type tricuspid valve prolapse. 61
32077927 2020
3
Features of Marfan syndrome not listed in the Ghent nosology - the dark side of the disease. 61
31829751 2019
4
Infrequent concomitant mitral, pulmonary, and tricuspid valve prolapse associated with right ventricular failure: Correct diagnosis using multimodality imaging. 61
31475958 2019
5
Heart failure and sudden cardiac death in heritable thoracic aortic disease caused by pathogenic variants in the SMAD3 gene. 61
29717556 2018
6
Infantile Marfan syndrome in a Korean tertiary referral center. 61
26958064 2016
7
Two- and Three-dimensional Transthoracic Echocardiographic Assessment of Tricuspid Valve Prolapse with Mid-to-Late Systolic Tricuspid Regurgitation. 61
25903919 2015
8
[Characteristics of risk factors in young and middle-aged patients with first hemispheric ischemic stroke]. 61
26978634 2015
9
Case images: tricuspid valve prolapse secondary to excessive long chordae evaluated by transthoracic echocardiography. 61
25620347 2014
10
Cutis laxa with pulmonary emphysema, conjunctivochalasis, nasolacrimal duct obstruction, abnormal hair, and a novel FBLN5 mutation. 61
24962763 2014
11
Left ventricular assist device implantation induced tricuspid valve prolapse. 61
24255057 2013
12
FBN1 gene mutation characteristics and clinical features for the prediction of mitral valve disease progression. 61
23176764 2013
13
Impact of age and gender on cardiac pathology in children and adolescents with Marfan syndrome. 61
23183959 2013
14
Robot-assisted repair of tricuspid leaflet prolapse using standard valvuloplasty techniques. 61
23409356 2012
15
Pectus excavatum: echocardiography and cardiac MRI reveal frequent pericardial effusion and right-sided heart anomalies. 61
22298154 2012
16
[Immunological characteristics in subjects with heart connective tissue dysplasia depending on thyroid hormone levels and vegetative dysfunction]. 61
23285764 2012
17
Tricuspid valve repair with artificial chordae in a 72-year-old woman. 61
21425060 2011
18
Echocardiographic findings in children with Marfan syndrome. 61
21161115 2011
19
Isolated tricuspid valve prolapsed: identification using two- and three-dimensional echocardiography and transoesophageal echocardiography. 61
21709929 2011
20
Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome. 61
20854973 2010
21
Flail mitral and tricuspid valves due to myxomatous disease. 61
17197244 2008
22
[Congenital tricuspid valve prolapse with severe regurgitation in one child]. 61
18289485 2008
23
Echocardiographic and clinical abnormalities in patients with psoriasis. 61
17294995 2006
24
Clinical correlates and mortality of hemodynamically significant tricuspid regurgitation. 61
15473480 2004
25
[Marfan syndrome in the newborn and infants less than 4 months: a series of 9 patients]. 61
12085746 2002
26
Marfan Syndrome 61
20301510 2001
27
[Acromegaly associated with mitral and tricuspid prolapse. Report of a case]. 61
10956612 2000
28
Relation between QT dispersion and ventricular arrhythmias in uncomplicated isolated mitral valve prolapse. 61
10614836 1999
29
Mimics of Ebstein's anomaly. 61
9327709 1997
30
Echocardiographic Changes in Cases of Intermittent Acute Porphyria. 61
11174947 1997
31
Abnormal ambulatory electrocardiographic findings in patients with the Marfan syndrome. 61
9104435 1997
32
Clinical and echocardiographic features of mitral valve prolapse patients in a local population. 61
8942249 1996
33
[Tricuspid valve prolapse]. 61
9117653 1996
34
Physiological valvular regurgitation in clinically normal young racehorses: prevalence and two-dimensional colour flow Doppler echocardiographic characteristics. 61
8933070 1995
35
Tricuspid valve prolapse associated with myxomatous degeneration. 61
7733736 1995
36
Bivalvular endocarditis complicating pregnancy. A case report and literature review. 61
7741329 1995
37
[Value of transesophageal echocardiography in the assessment of blunt chest trauma: correlation with electrocardiogram, heart enzymes, and transthoracic echocardiogram]. 61
7848654 1994
38
Valvular heart disease: the influence of changing etiology on nosology. 61
8000586 1994
39
[Multiple heart valve involvement in renal polycystic disease in the adult]. 61
8066312 1994
40
[Doppler echocardiography in endomyocardial fibrosis]. 61
7979815 1994
41
Development of valve dysfunction in adolescents and young adults with Down syndrome and no known congenital heart disease. 61
8496770 1993
42
[Cardiovascular manifestations of hereditary dysplasias of connective tissue]. 61
8517593 1993
43
[Atrial septal aneurysm and associated anomalies. Personal experience with 38 cases]. 61
8510815 1993
44
[Pathology and histochemistry of mitral valve prolapse]. 61
8164136 1993
45
Transesophageal echocardiography: normal variants and mimickers. 61
1341889 1992
46
[Marfan syndrome in childhood: cardiovascular manifestations. Echocardiographic changes]. 61
1416516 1992
47
[Valvular prolapse in autosomal dominant polycystic kidney]. 61
1473656 1992
48
[Cardiovascular abnormalities in Marfan syndrome]. 61
1620255 1992
49
The spectrum of cardiovascular abnormalities in autosomal dominant polycystic kidney disease: a 10-year follow-up in a five-generation kindred. 61
1606775 1992
50
[A clinicopathologic study of morphologic tricuspid valve prolapse in the aged: comparison with color Doppler evaluation]. 61
1418879 1992

Variations for Tricuspid Valve Prolapse

Expression for Tricuspid Valve Prolapse

Search GEO for disease gene expression data for Tricuspid Valve Prolapse.

Pathways for Tricuspid Valve Prolapse

Pathways related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN2
2
Show member pathways
13.33 TGFBR2 TGFBR1 TGFB3 TGFB2 FBN2 FBN1
3
Show member pathways
13.22 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 SLC2A10
4
Show member pathways
13.01 TGFBR1 TGFB3 TGFB2 FBN2 FBN1 EFEMP2
5
Show member pathways
12.98 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
6
Show member pathways
12.8 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
7 12.78 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
8
Show member pathways
12.74 TGFBR2 TGFBR1 TGFB3 TGFB2
9
Show member pathways
12.71 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
10 12.67 TGFBR2 TGFBR1 TGFB3 TGFB2
11
Show member pathways
12.6 TGFB3 TGFB2 FBN2 FBN1 FBLN5 EFEMP2
12
Show member pathways
12.56 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
13
Show member pathways
12.45 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
14 12.31 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
15
Show member pathways
12.2 TGFBR2 TGFBR1 SMAD3
16 12.2 TGFBR1 TGFB3 TGFB2 SMAD3
17
Show member pathways
12.18 TGFBR2 TGFBR1 SMAD3
18
Show member pathways
12.18 TGFBR2 TGFBR1 TGFB2 SMAD3
19 12.16 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
20 12.12 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
21 12.1 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
22 12.04 TGFBR2 TGFB2 SLC2A10
23
Show member pathways
12.03 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
24 12 TGFBR2 TGFBR1 SMAD3
25 11.98 TGFBR2 TGFBR1 TGFB2
26 11.87 TGFB3 TGFB2 COL3A1
27 11.84 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
28
Show member pathways
11.83 TGFBR2 TGFBR1 SMAD3
29 11.8 TGFBR1 TGFB3 TGFB2
30 11.8 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
31
Show member pathways
11.79 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
32
Show member pathways
11.74 TGFBR2 TGFBR1 SMAD3
33 11.71 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 FBN1
34 11.7 TGFBR2 TGFBR1 SMAD3
35 11.69 TGFBR2 TGFBR1 SMAD3
36 11.69 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
37
Show member pathways
11.68 TGFBR2 TGFBR1 SMAD3
38 11.59 TGFBR2 TGFBR1 SMAD3
39
Show member pathways
11.57 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
40 11.54 TGFBR2 TGFBR1 TGFB3 SMAD3
41 11.51 TGFBR2 TGFBR1 TGFB2
42
Show member pathways
11.23 TGFBR2 TGFBR1 TGFB3
43 11.21 TGFBR2 TGFBR1 TGFB3
44 11.11 TGFBR2 TGFBR1 SMAD3
45 11.03 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
46 10.97 TGFB3 TGFB2 FBN2 FBN1 EFEMP2 COL3A1
47
Show member pathways
10.96 TGFB3 TGFB2 FBN2 FBN1 FBLN5 EFEMP2
48 10.9 TGFBR2 TGFBR1 TGFB3 TGFB2
49 10.77 TGFB3 TGFB2
50 10.75 TGFBR2 TGFBR1 SMAD3 FBN2 FBN1

GO Terms for Tricuspid Valve Prolapse

Cellular components related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 TGFB3 TGFB2 FBN1 FBLN5 EFEMP2 COL3A1
2 extracellular region GO:0005576 9.8 TGFB3 TGFB2 FBN2 FBN1 FBLN5 EFEMP2
3 receptor complex GO:0043235 9.54 TGFBR2 TGFBR1 SMAD3
4 extracellular matrix GO:0031012 9.26 FBN2 FBN1 FBLN5 COL3A1
5 collagen-containing extracellular matrix GO:0062023 9.17 TGFB3 TGFB2 FBN2 FBN1 FBLN5 EFEMP2
6 microfibril GO:0001527 9.16 FBN2 FBN1

Biological processes related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10 TGFBR2 TGFBR1 TGFB3 TGFB2
2 negative regulation of cell proliferation GO:0008285 9.99 TGFBR2 TGFB3 TGFB2 SMAD3
3 extracellular matrix organization GO:0030198 9.94 FBN2 FBN1 FBLN5 COL3A1
4 in utero embryonic development GO:0001701 9.94 TGFBR2 TGFBR1 TGFB3 SMAD3
5 cell cycle arrest GO:0007050 9.86 TGFBR1 TGFB2 SMAD3
6 kidney development GO:0001822 9.85 TGFBR1 TGFB2 FBN1
7 response to hypoxia GO:0001666 9.83 TGFBR2 TGFB3 TGFB2 SMAD3 PDLIM1
8 cellular response to transforming growth factor beta stimulus GO:0071560 9.81 TGFBR1 SMAD3 FBN1
9 SMAD protein signal transduction GO:0060395 9.8 TGFB3 TGFB2 SMAD3
10 skeletal system development GO:0001501 9.8 TGFBR1 TGFB2 SMAD3 FBN1 COL3A1
11 heart development GO:0007507 9.8 TGFBR2 TGFBR1 TGFB2 PDLIM1 FBN1 COL3A1
12 positive regulation of stress fiber assembly GO:0051496 9.79 TGFBR1 TGFB3 SMAD3
13 collagen fibril organization GO:0030199 9.77 TGFBR1 TGFB2 COL3A1
14 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.76 TGFBR1 TGFB3 TGFB2
15 ventricular septum morphogenesis GO:0060412 9.74 TGFBR2 TGFBR1 TGFB2
16 positive regulation of bone mineralization GO:0030501 9.73 TGFB3 SMAD3 FBN2
17 embryonic cranial skeleton morphogenesis GO:0048701 9.72 TGFBR2 TGFBR1 SMAD3
18 digestive tract development GO:0048565 9.71 TGFBR2 TGFB3 COL3A1
19 gastrulation GO:0007369 9.7 TGFBR2 SMAD3
20 positive regulation of filopodium assembly GO:0051491 9.69 TGFBR1 TGFB3
21 outflow tract septum morphogenesis GO:0003148 9.69 TGFBR2 TGFB2
22 cell-cell junction organization GO:0045216 9.69 TGFB3 TGFB2 SMAD3
23 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.68 TGFBR2 TGFBR1
24 ventricular trabecula myocardium morphogenesis GO:0003222 9.68 TGFBR1 TGFB2
25 positive regulation of SMAD protein signal transduction GO:0060391 9.67 TGFBR1 TGFB3
26 cardiac epithelial to mesenchymal transition GO:0060317 9.67 TGFBR1 TGFB2
27 atrioventricular valve morphogenesis GO:0003181 9.67 TGFBR2 TGFB2
28 activin receptor signaling pathway GO:0032924 9.67 TGFBR2 TGFBR1 SMAD3
29 response to cholesterol GO:0070723 9.66 TGFBR2 TGFBR1
30 elastic fiber assembly GO:0048251 9.66 FBLN5 EFEMP2
31 embryonic eye morphogenesis GO:0048048 9.65 FBN2 FBN1
32 salivary gland morphogenesis GO:0007435 9.65 TGFB3 TGFB2
33 membranous septum morphogenesis GO:0003149 9.65 TGFBR2 TGFB2
34 secondary palate development GO:0062009 9.65 TGFBR2 TGFB3 TGFB2
35 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.65 TGFBR2 TGFBR1 TGFB3 SMAD3 SLC2A10
36 pathway-restricted SMAD protein phosphorylation GO:0060389 9.63 TGFBR2 TGFBR1 TGFB2
37 negative regulation of macrophage cytokine production GO:0010936 9.62 TGFB3 TGFB2
38 sequestering of TGFbeta in extracellular matrix GO:0035583 9.61 FBN2 FBN1
39 regulation of transforming growth factor beta2 production GO:0032909 9.61 TGFB2 SMAD3
40 endocardial cushion fusion GO:0003274 9.6 TGFBR2 TGFB2
41 positive regulation of tight junction disassembly GO:1905075 9.58 TGFBR1 TGFB3
42 positive regulation of epithelial to mesenchymal transition GO:0010718 9.55 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3
43 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 9.54 TGFBR2 TGFBR1 TGFB2
44 uterine wall breakdown GO:0042704 9.52 TGFB3 TGFB2
45 transforming growth factor beta receptor signaling pathway GO:0007179 9.43 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1
46 wound healing GO:0042060 9.1 TGFBR2 TGFBR1 TGFB3 TGFB2 SMAD3 COL3A1

Molecular functions related to Tricuspid Valve Prolapse according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.69 FBN1 FBLN5 COL3A1
2 extracellular matrix structural constituent GO:0005201 9.67 FBN2 FBN1 EFEMP2 COL3A1
3 transforming growth factor beta binding GO:0050431 9.5 TGFBR2 TGFBR1 TGFB3
4 activin binding GO:0048185 9.49 TGFBR2 TGFBR1
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.48 TGFBR2 TGFBR1
6 type I transforming growth factor beta receptor binding GO:0034713 9.46 TGFBR2 TGFB3
7 transforming growth factor beta-activated receptor activity GO:0005024 9.43 TGFBR2 TGFBR1
8 transforming growth factor beta receptor binding GO:0005160 9.43 TGFB3 TGFB2 SMAD3
9 type III transforming growth factor beta receptor binding GO:0034714 9.4 TGFB3 TGFB2
10 extracellular matrix constituent conferring elasticity GO:0030023 9.33 FBN2 FBN1 FBLN5
11 SMAD binding GO:0046332 9.26 TGFBR2 TGFBR1 SMAD3 COL3A1
12 type II transforming growth factor beta receptor binding GO:0005114 8.8 TGFBR1 TGFB3 TGFB2

Sources for Tricuspid Valve Prolapse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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