MCID: TRC021
MIFTS: 40

Tricuspid Valve Stenosis

Categories: Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Stenosis

MalaCards integrated aliases for Tricuspid Valve Stenosis:

Name: Tricuspid Valve Stenosis 12 44 15 73
Tricuspid Stenosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4078
MeSH 44 D014264
NCIt 50 C50783
ICD10 33 I07.0 I07.2
UMLS 73 C0040963

Summaries for Tricuspid Valve Stenosis

Disease Ontology : 12 A tricuspid valve disease that is characterized by the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve.

MalaCards based summary : Tricuspid Valve Stenosis, also known as tricuspid stenosis, is related to tricuspid atresia and hypoplastic left heart syndrome. An important gene associated with Tricuspid Valve Stenosis is HEY2 (Hes Related Family BHLH Transcription Factor With YRPW Motif 2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hypothesized Pathways in Pathogenesis of Cardiovascular Disease. The drugs Sevoflurane and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and colon, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Tricuspid Valve Stenosis is a valvular heart disease that narrows the opening of the heart\'s tricuspid... more...

Related Diseases for Tricuspid Valve Stenosis

Diseases related to Tricuspid Valve Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 tricuspid atresia 31.6 CRELD1 HEY2 NKX2-6
2 hypoplastic left heart syndrome 29.5 GJA1 NKX2-6 NOTCH1
3 tricuspid valve disease 29.3 ARSE CRELD1 FBN1 HEY2 NKX2-6
4 atrial heart septal defect 29.2 CRELD1 IL4I1 NKX2-6
5 heart disease 28.2 CRELD1 FBN1 GJA1 JAG1 NKX2-6 NOTCH1
6 congenital tricuspid stenosis 12.3
7 pulmonary valve insufficiency 10.5 NKX2-6 SLC6A11
8 discrete subaortic stenosis 10.5 CRELD1 NOTCH1
9 pulmonary valve disease 10.4 CRELD1 NKX2-6 SLC6A11
10 aortic aneurysm, familial thoracic 2 10.4 FBN1 FLNA
11 pulmonary valve stenosis 10.3 JAG1 NKX2-6
12 total anomalous pulmonary venous return 1 10.3 CRELD1 NKX2-6
13 aortic valve insufficiency 10.3 FBN1 NKX2-6 NOTCH1
14 nodular regenerative hyperplasia 10.2 JAG1 NOTCH1
15 radial neuropathy 10.2 NOTCH1 SERPINA1
16 endocarditis 10.2
17 aortic valve disease 2 10.2 FBN1 NKX2-6 NOTCH1
18 tricuspid valve insufficiency 10.2 ARSE CA6 CRELD1 FBN1
19 diaphragmatic eventration 10.1 FBN1 FLNA NKX2-6
20 atrioventricular septal defect 10.1 CRELD1 GJA1 NKX2-6
21 tricuspid valve agenesis 10.1
22 infective endocarditis 10.1
23 hajdu-cheney syndrome 10.0 FLNA JAG1 NOTCH1
24 anomalous left coronary artery from the pulmonary artery 10.0 CRELD1 GJA1
25 allergic urticaria 9.9 ENSG00000264813 SERPINA1
26 chorioangioma 9.9 CRELD1 NOTCH1
27 transposition of the great arteries, dextro-looped 1 9.9
28 end stage renal failure 9.9
29 sarcoma 9.9
30 cardiac tamponade 9.9
31 mitral valve stenosis 9.9
32 lutembacher's syndrome 9.9
33 situs inversus 9.9
34 double discordia 9.9
35 double outlet right atrium 9.9
36 aneurysm 9.9
37 interatrial communication 9.9
38 levocardia 9.9
39 ebstein anomaly 9.7
40 endocardial fibroelastosis 9.7
41 hypoplastic left heart syndrome 1 9.7
42 hydrops fetalis, nonimmune, and/or atrial septal defect 9.7
43 hepatitis 9.7
44 hydrops fetalis 9.7
45 aortic valve disease 1 9.3 FBN1 IL4I1 NKX2-6 NOTCH1
46 tetralogy of fallot 8.8 CRELD1 FBN1 GJA1 HEY2 JAG1 NKX2-6

Graphical network of the top 20 diseases related to Tricuspid Valve Stenosis:



Diseases related to Tricuspid Valve Stenosis

Symptoms & Phenotypes for Tricuspid Valve Stenosis

MGI Mouse Phenotypes related to Tricuspid Valve Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 FBN1 FLNA GJA1 HEY2 JAG1 NKX2-6
2 cellular MP:0005384 10.14 BUB1B CD59 CRELD1 FBN1 FLNA GJA1
3 mortality/aging MP:0010768 10.07 BUB1B CD59 CRELD1 FBN1 FLNA GJA1
4 embryo MP:0005380 9.92 FBN1 GJA1 HEY2 JAG1 NKX2-6 NOTCH1
5 craniofacial MP:0005382 9.91 FLNA GJA1 HEY2 JAG1 NOTCH1 CRELD1
6 muscle MP:0005369 9.76 OXTR YWHAE BUB1B FBN1 GJA1 HEY2
7 nervous system MP:0003631 9.7 CRELD1 FBN1 FLNA GJA1 HEY2 JAG1
8 respiratory system MP:0005388 9.17 BUB1B FBN1 FLNA GJA1 HEY2 NKX2-6

Drugs & Therapeutics for Tricuspid Valve Stenosis

Drugs for Tricuspid Valve Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved 28523-86-6 5206
2 Anesthetics
3 Anesthetics, General
4 Anesthetics, Inhalation
5 Central Nervous System Depressants
6 Platelet Aggregation Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Determine the Effective Dose 95 of Sevoflurane in Adult Patients Recruiting NCT02711384

Search NIH Clinical Center for Tricuspid Valve Stenosis

Cochrane evidence based reviews: tricuspid valve stenosis

Genetic Tests for Tricuspid Valve Stenosis

Anatomical Context for Tricuspid Valve Stenosis

MalaCards organs/tissues related to Tricuspid Valve Stenosis:

41
Heart, Liver, Colon

Publications for Tricuspid Valve Stenosis

Articles related to Tricuspid Valve Stenosis:

(show top 50) (show all 52)
# Title Authors Year
1
Percutaneous Valvuloplasty for Bioprosthetic Tricuspid Valve Stenosis. ( 28265212 )
2017
2
Balloon dilatation of isolated severe tricuspid valve stenosis. ( 26995441 )
2015
3
Acquired tricuspid valve stenosis due to intentionally redundant transvenous lead placement for VDD pacing in two small dogs. ( 26463216 )
2015
4
Acquired tricuspid valve stenosis associated with two ventricular endocardial pacing leads in a dog. ( 25955141 )
2015
5
Percutaneous transcatheter balloon valvuloplasty for bioprosthetic tricuspid valve stenosis in a patient with orthotopic heart transplant. ( 25740974 )
2015
6
The Forgotten Valve: Isolated Severe Tricuspid Valve Stenosis. ( 26283605 )
2015
7
Giant right atrium due to rheumatic tricuspid valve stenosis. ( 26005174 )
2015
8
Reversible tricuspid valve stenosis induced by ascending aorta aneurysm: an image focus. ( 25706906 )
2015
9
Percutaneous valvuloplasty for severe bioprosthetic tricuspid valve stenosis in the setting of infective endocarditis. ( 24399759 )
2014
10
Balloon valvuloplasty for bioprosthetic tricuspid valve stenosis. ( 24653745 )
2014
11
Isolated tricuspid valve stenosis--probably of rheumatic etiology. ( 25672046 )
2014
12
Dynamic tricuspid valve stenosis induced with a pacemaker lead: a case report. ( 24779342 )
2014
13
Inoue balloon valvuloplasty for rheumatic tricuspid valve stenosis: an excellent technique with some intrinsic difficulties. ( 23756413 )
2013
14
Pacemaker lead-induced severe tricuspid valve stenosis: complete percutaneous extraction under extracorporeal life support. ( 23515340 )
2013
15
Repair of rheumatic tricuspid valve stenosis with autologous pericardium. ( 23958528 )
2013
16
Bioprosthetic tricuspid valve stenosis in end-stage renal failure. ( 22104429 )
2012
17
Unusual case of colonized pacemaker lead presenting with endocarditis, hemoptysis and tricuspid valve stenosis. ( 21766083 )
2011
18
Giant saphenous vein graft pseudoaneurysm causing tricuspid valve stenosis. ( 21332791 )
2011
19
Platypnea-orthodeoxia syndrome associated with bioprosthetic tricuspid valve stenosis and reverse Lutembacher syndrome. ( 21300958 )
2011
20
Aseptic Endocarditis in BehAset's Disease Presenting as Tricuspid Valve Stenosis. ( 21860642 )
2011
21
Situs inversus with levocardia and congenitally corrected transposition of great vessels with rheumatic tricuspid valve stenosis and regurgitation. ( 22574246 )
2011
22
Luminal vena cava superior and right atrial obstruction associated with severe tricuspid valve stenosis due to endocardial pacemaker leads: an extremely rare complication of permanent pacemakers. ( 20080868 )
2010
23
Balloon valvuloplasty of a tricuspid valve stenosis in double balloon technique. ( 20049464 )
2010
24
Tricuspid valve stenosis due to a pacemaker lead. ( 21144412 )
2010
25
Pacemaker lead-induced severe tricuspid valve stenosis. ( 20484199 )
2010
26
Percutaneous transcatheter balloon valvuloplasty for severe tricuspid valve stenosis in Ebstein's anomaly. ( 19507300 )
2009
27
Severe tricuspid valve stenosis secondary to pacemaker leads presenting as ascites and liver dysfunction: a complex problem requiring a multidisciplinary therapeutic approach. ( 18850261 )
2009
28
Evaluation of rheumatic tricuspid valve stenosis by real-time three-dimensional echocardiography. ( 17322513 )
2007
29
Tricuspid valve stenosis caused by fibrous adhesions to an endocardial pacemaker lead in a dog. ( 18229427 )
2007
30
Tricuspid valve stenosis related to subvalvular adhesion of pacemaker lead: a case report. ( 16800373 )
2006
31
Images in cardiovascular medicine. Percutaneous transcatheter balloon valvuloplasty for bioprosthetic tricuspid valve stenosis. ( 17075017 )
2006
32
What is your diagnosis? Tricuspid valve stenosis (TS). ( 15789812 )
2005
33
Reversible tricuspid valve stenosis due to a metastatic dissemination of a noncardiac sarcoma. ( 15975327 )
2005
34
One-year follow-up of a patient with reversible tricuspid valve stenosis due to lymphomatic mass into the right atrioventricular wall. ( 12376008 )
2002
35
Surgical palliation of severe tricuspid valve stenosis in a dog by use of Fontan's procedure. ( 10493641 )
1999
36
Severe bioprosthetic tricuspid valve stenosis with systolic antegrade flow across the tricuspid valve. ( 8858510 )
1996
37
Pathology of tricuspid valve stenosis and pure tricuspid regurgitation--Part I. ( 7720297 )
1995
38
Pathology of tricuspid valve stenosis and pure tricuspid regurgitation--Part III. ( 7788951 )
1995
39
Valved conduit bypass for extensively calcified tricuspid valve stenosis. ( 7646118 )
1995
40
Isolated tricuspid valve stenosis caused by infective endocarditis in an adult: report of a case. ( 8118123 )
1993
41
Initial outcome of percutaneous balloon valvuloplasty in rheumatic tricuspid valve stenosis. ( 8427185 )
1993
42
Concurrent dilatation of mitral and tricuspid valve stenosis using a single Inoue balloon: a report of 2 cases. ( 8287468 )
1993
43
Bioprosthetic tricuspid valve stenosis associated with extensive plaque deposition in carcinoid heart disease. ( 2035407 )
1991
44
Right-sided infective endocarditis with acquired tricuspid valve stenosis associated with transvenous pacemaker: a case report. ( 1715545 )
1991
45
Congenital tricuspid valve stenosis with atrial septal defect and left anterior fascicular block. ( 2364584 )
1990
46
Surgical creation of a double outlet right atrium for tricuspid valve stenosis after a Rastelli operation. ( 3415878 )
1988
47
Combined mitral valve stenosis and tricuspid valve stenosis: morphologic observations after mitral and tricuspid valve replacements or mitral replacement and tricuspid valve commissurotomy. ( 3766427 )
1986
48
Usefulness of Doppler echocardiography in detecting tricuspid valve stenosis. ( 3969915 )
1985
49
Delayed postoperative cardiac tamponade mimicking severe tricuspid valve stenosis. ( 6723397 )
1984
50
A rare case of an adult with mitral, pulmonary and tricuspid valve stenosis with an interatrial communication and acquired cyanosis. ( 6500622 )
1984

Variations for Tricuspid Valve Stenosis

Expression for Tricuspid Valve Stenosis

Search GEO for disease gene expression data for Tricuspid Valve Stenosis.

Pathways for Tricuspid Valve Stenosis

GO Terms for Tricuspid Valve Stenosis

Cellular components related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.35 CD59 GJA1 NOTCH1 SERPINA1 SNAPIN
2 apical plasma membrane GO:0016324 8.92 GJA1 JAG1 NOTCH1 OXTR

Biological processes related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.77 HEY2 JAG1 NOTCH1
2 neuronal stem cell population maintenance GO:0097150 9.61 JAG1 NOTCH1
3 embryonic heart tube development GO:0035050 9.6 GJA1 NKX2-6
4 ventricular trabecula myocardium morphogenesis GO:0003222 9.58 HEY2 NOTCH1
5 negative regulation of stem cell differentiation GO:2000737 9.58 JAG1 NOTCH1
6 cardiac right ventricle morphogenesis GO:0003215 9.57 HEY2 JAG1
7 cardiac epithelial to mesenchymal transition GO:0060317 9.56 HEY2 NOTCH1
8 response to muramyl dipeptide GO:0032495 9.55 JAG1 NOTCH1
9 endocardial cushion development GO:0003197 9.54 CRELD1 NOTCH1
10 ventricular cardiac muscle cell development GO:0055015 9.52 HEY2 NKX2-6
11 cardiac left ventricle morphogenesis GO:0003214 9.51 HEY2 NOTCH1
12 cardiac ventricle morphogenesis GO:0003208 9.49 HEY2 NOTCH1
13 mesenchymal cell development GO:0014031 9.48 HEY2 NOTCH1
14 regulation of inner ear auditory receptor cell differentiation GO:0045607 9.46 HEY2 NOTCH1
15 pulmonary artery morphogenesis GO:0061156 9.43 HEY2 JAG1
16 cardiac septum morphogenesis GO:0060411 9.43 HEY2 JAG1 NOTCH1
17 arterial endothelial cell differentiation GO:0060842 9.4 HEY2 NOTCH1
18 distal tubule development GO:0072017 9.37 JAG1 NOTCH1
19 pulmonary valve morphogenesis GO:0003184 9.33 HEY2 JAG1 NOTCH1
20 cardiac vascular smooth muscle cell development GO:0060948 9.32 HEY2 NOTCH1
21 Notch signaling involved in heart development GO:0061314 9.13 HEY2 JAG1 NOTCH1
22 heart development GO:0007507 9.1 FBN1 GJA1 HEY2 NKX2-6 NOTCH1 OXTR

Molecular functions related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch binding GO:0005112 8.62 JAG1 NOTCH1

Sources for Tricuspid Valve Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....