MCID: TRC021
MIFTS: 43

Tricuspid Valve Stenosis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Stenosis

MalaCards integrated aliases for Tricuspid Valve Stenosis:

Name: Tricuspid Valve Stenosis 12 44 15 73
Tricuspid Stenosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4078
MeSH 44 D014264
NCIt 50 C50783
SNOMED-CT 68 49915006
ICD10 33 I07.0 I07.2
UMLS 73 C0040963

Summaries for Tricuspid Valve Stenosis

Disease Ontology : 12 A tricuspid valve disease that is characterized by the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve.

MalaCards based summary : Tricuspid Valve Stenosis, also known as tricuspid stenosis, is related to tricuspid atresia and tricuspid valve insufficiency. An important gene associated with Tricuspid Valve Stenosis is HEY2 (Hes Related Family BHLH Transcription Factor With YRPW Motif 2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Canonical and Non-canonical Notch signaling. The drugs Sevoflurane and Anesthetics, Inhalation have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and liver, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Tricuspid Valve Stenosis is a valvular heart disease that narrows the opening of the heart''s tricuspid... more...

Related Diseases for Tricuspid Valve Stenosis

Diseases related to Tricuspid Valve Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 tricuspid atresia 31.3 CRELD1 HEY2 NKX2-6
2 tricuspid valve insufficiency 30.4 ARSE CA6 CRELD1 FBN1
3 mitral valve stenosis 30.0 BUB1B CRELD1
4 atrial heart septal defect 29.8 CRELD1 IL4I1 NKX2-6
5 hypoplastic left heart syndrome 29.7 GJA1 NKX2-6 NOTCH1
6 tricuspid valve disease 29.6 ARSE CRELD1 FBN1 HEY2 NKX2-6
7 heart disease 29.5 CRELD1 GJA1 JAG1 NKX2-6 NOTCH1
8 congenital tricuspid stenosis 12.5
9 endocarditis 10.3
10 tricuspid valve agenesis 10.2
11 pericarditis 10.2
12 infective endocarditis 10.2
13 pulmonary valve insufficiency 10.2 NKX2-6 SLC6A11
14 total anomalous pulmonary venous return 1 10.2 CRELD1 NKX2-6
15 discrete subaortic stenosis 10.1 CRELD1 NOTCH1
16 pulmonary valve disease 10.1 CRELD1 NKX2-6 SLC6A11
17 constrictive pericarditis 10.1
18 chorioangioma 10.1 CRELD1 NOTCH1
19 anomalous left coronary artery from the pulmonary artery 10.1 CRELD1 GJA1
20 nodular regenerative hyperplasia 10.1 JAG1 NOTCH1
21 radial neuropathy 10.1 NOTCH1 SERPINA1
22 pulmonary valve stenosis 10.1 CRELD1 JAG1 NKX2-6
23 rheumatic heart disease 10.1
24 malignant essential hypertension 10.1 ARSE ENSG00000264813
25 aortic valve insufficiency 10.0 FBN1 NKX2-6 NOTCH1
26 alagille syndrome 1 10.0 HEY2 JAG1 NOTCH1
27 aortic coarctation 10.0 FBN1 NOTCH1
28 atrioventricular septal defect 10.0 CRELD1 GJA1 NKX2-6
29 ossifying fibroma 10.0 JAG1 NOTCH1
30 allergic urticaria 10.0 ENSG00000264813 SERPINA1
31 aneurysm of sinus of valsalva 10.0
32 transposition of the great arteries, dextro-looped 1 10.0
33 end stage renal failure 10.0
34 lymphoma 10.0
35 sarcoma 10.0
36 cardiac tamponade 10.0
37 lutembacher's syndrome 10.0
38 situs inversus 10.0
39 double discordia 10.0
40 double outlet right atrium 10.0
41 interatrial communication 10.0
42 levocardia 10.0
43 mitral valve insufficiency 9.9 CRELD1 FBN1 IL4I1
44 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.9 JAG1 NOTCH1
45 systemic lupus erythematosus 9.8
46 ebstein anomaly 9.8
47 endocardial fibroelastosis 9.8
48 hypoplastic left heart syndrome 1 9.8
49 myocardial infarction 9.8
50 cholangitis, primary sclerosing 9.8

Graphical network of the top 20 diseases related to Tricuspid Valve Stenosis:



Diseases related to Tricuspid Valve Stenosis

Symptoms & Phenotypes for Tricuspid Valve Stenosis

MGI Mouse Phenotypes related to Tricuspid Valve Stenosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.1 BUB1B CRELD1 FBN1 GJA1 HEY2 JAG1
2 cellular MP:0005384 10.07 BUB1B CD59 CRELD1 FBN1 GJA1 JAG1
3 mortality/aging MP:0010768 9.93 BUB1B CD59 CRELD1 FBN1 GJA1 HEY2
4 embryo MP:0005380 9.86 BUB1B CRELD1 FBN1 GJA1 HEY2 JAG1
5 craniofacial MP:0005382 9.8 CRELD1 FBN1 GJA1 HEY2 JAG1 NOTCH1
6 muscle MP:0005369 9.56 BUB1B FBN1 GJA1 HEY2 JAG1 NOTCH1
7 nervous system MP:0003631 9.32 CRELD1 FBN1 GJA1 HEY2 JAG1 NOTCH1

Drugs & Therapeutics for Tricuspid Valve Stenosis

Drugs for Tricuspid Valve Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved 28523-86-6 5206
2 Anesthetics, Inhalation
3 Central Nervous System Depressants
4 Platelet Aggregation Inhibitors
5 Anesthetics
6 Anesthetics, General

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Determine the Effective Dose 95 of Sevoflurane in Adult Patients Recruiting NCT02711384

Search NIH Clinical Center for Tricuspid Valve Stenosis

Cochrane evidence based reviews: tricuspid valve stenosis

Genetic Tests for Tricuspid Valve Stenosis

Anatomical Context for Tricuspid Valve Stenosis

MalaCards organs/tissues related to Tricuspid Valve Stenosis:

41
Heart, Brain, Liver, Colon

Publications for Tricuspid Valve Stenosis

Articles related to Tricuspid Valve Stenosis:

(show top 50) (show all 232)
# Title Authors Year
1
Large Primary Cardiac Lymphoma Causing Functional Tricuspid Valve Stenosis. ( 30374246 )
2018
2
Tricuspid stenosis: A rare and potential complication of ventricular septal occluder device. ( 29652285 )
2018
3
Percutaneous Valvuloplasty for Bioprosthetic Tricuspid Valve Stenosis. ( 28265212 )
2017
4
Functional tricuspid stenosis: a rare presentation of suspected rhabdomyoma as congenital cyanotic heart disease. ( 28077182 )
2017
5
Balloon Valvuloplasty of Tricuspid Stenosis: A Retrospective Study of 5 Labrador Retriever Dogs. ( 28220526 )
2017
6
Surgical management of tricuspid stenosis. ( 28706872 )
2017
7
Case Image: Unruptured non-coronary sinus of Valsalva aneurysm presenting with nausea secondary to functional tricuspid stenosis. ( 29226903 )
2017
8
Tricuspid stenosis: An emerging disease in cardiac implantable electronic devices era. Case report and literature review. ( 30279777 )
2017
9
Letter by TunAsez et al Regarding Article, "The Forgotten Valve: Isolated Severe Tricuspid Valve Stenosis". ( 26903023 )
2016
10
Functional Tricuspid Stenosis in Primary Sclerosing Cholangitis: A Case Report. ( 26903307 )
2016
11
An unusual cause of severe tricuspid stenosis. ( 26875140 )
2016
12
Balloon dilatation of isolated severe tricuspid valve stenosis. ( 26995441 )
2015
13
Acquired tricuspid valve stenosis due to intentionally redundant transvenous lead placement for VDD pacing in two small dogs. ( 26463216 )
2015
14
Acquired tricuspid valve stenosis associated with two ventricular endocardial pacing leads in a dog. ( 25955141 )
2015
15
Percutaneous transcatheter balloon valvuloplasty for bioprosthetic tricuspid valve stenosis in a patient with orthotopic heart transplant. ( 25740974 )
2015
16
The Forgotten Valve: Isolated Severe Tricuspid Valve Stenosis. ( 26283605 )
2015
17
Giant right atrium due to rheumatic tricuspid valve stenosis. ( 26005174 )
2015
18
Reversible tricuspid valve stenosis induced by ascending aorta aneurysm: an image focus. ( 25706906 )
2015
19
Transesophageal echocardiographic diagnosis of severe functional tricuspid stenosis during infected implantable cardioverter-defibrillator lead extraction. ( 25440647 )
2015
20
Right atrial myxoma mimicking tricuspid stenosis. ( 26272962 )
2015
21
Thrombotic Obstruction of a Melody Valve-in-Valve Used for Prosthetic Tricuspid Stenosis. ( 26467885 )
2015
22
Neonatal tricuspid stenosis caused by device closure of a large coronary fistula. ( 26603866 )
2015
23
Asymptomatic Tricuspid Stenosis Following a Complex Lead Extraction Procedure. ( 26901908 )
2015
24
Percutaneous tricuspid valvotomy for pacemaker lead-induced tricuspid stenosis. ( 26995417 )
2015
25
Percutaneous valvuloplasty for severe bioprosthetic tricuspid valve stenosis in the setting of infective endocarditis. ( 24399759 )
2014
26
Balloon valvuloplasty for bioprosthetic tricuspid valve stenosis. ( 24653745 )
2014
27
Isolated tricuspid valve stenosis--probably of rheumatic etiology. ( 25672046 )
2014
28
Dynamic tricuspid valve stenosis induced with a pacemaker lead: a case report. ( 24779342 )
2014
29
Amyloidosis-induced tricuspid stenosis mimicking rheumatic heart disease. ( 24797117 )
2014
30
Percutaneous balloon valvotomy for the treatment of pacemaker lead-induced tricuspid stenosis. ( 24052372 )
2014
31
Pacemaker lead-related tricuspid stenosis successfully treated with percutaneous balloon valvuloplasty guided by 3D echocardiography. ( 25455950 )
2014
32
Inoue balloon valvuloplasty for rheumatic tricuspid valve stenosis: an excellent technique with some intrinsic difficulties. ( 23756413 )
2013
33
Pacemaker lead-induced severe tricuspid valve stenosis: complete percutaneous extraction under extracorporeal life support. ( 23515340 )
2013
34
Repair of rheumatic tricuspid valve stenosis with autologous pericardium. ( 23958528 )
2013
35
How should I treat prosthetic tricuspid stenosis in an extreme surgical risk patient? ( 23872655 )
2013
36
Bioprosthetic tricuspid valve stenosis in end-stage renal failure. ( 22104429 )
2012
37
Early prenatal diagnosis of tricuspid stenosis. ( 22964066 )
2012
38
Unusual case of colonized pacemaker lead presenting with endocarditis, hemoptysis and tricuspid valve stenosis. ( 21766083 )
2011
39
Giant saphenous vein graft pseudoaneurysm causing tricuspid valve stenosis. ( 21332791 )
2011
40
Platypnea-orthodeoxia syndrome associated with bioprosthetic tricuspid valve stenosis and reverse Lutembacher syndrome. ( 21300958 )
2011
41
Aseptic Endocarditis in BehAset's Disease Presenting as Tricuspid Valve Stenosis. ( 21860642 )
2011
42
Situs inversus with levocardia and congenitally corrected transposition of great vessels with rheumatic tricuspid valve stenosis and regurgitation. ( 22574246 )
2011
43
Valvuloplasty for tricuspid stenosis caused by a ventriculoatrial shunt. ( 20824751 )
2011
44
Luminal vena cava superior and right atrial obstruction associated with severe tricuspid valve stenosis due to endocardial pacemaker leads: an extremely rare complication of permanent pacemakers. ( 20080868 )
2010
45
Balloon valvuloplasty of a tricuspid valve stenosis in double balloon technique. ( 20049464 )
2010
46
Tricuspid valve stenosis due to a pacemaker lead. ( 21144412 )
2010
47
Pacemaker lead-induced severe tricuspid valve stenosis. ( 20484199 )
2010
48
Down to the wire: tricuspid stenosis in the setting of multiple pacing leads. ( 20070545 )
2010
49
Giant unruptured non-coronary sinus of Valsalva aneurysm presenting as tricuspid stenosis. ( 20138535 )
2010
50
Tricuspid balloon valvuloplasty to treat tricuspid stenosis. ( 20329507 )
2010

Variations for Tricuspid Valve Stenosis

Expression for Tricuspid Valve Stenosis

Search GEO for disease gene expression data for Tricuspid Valve Stenosis.

Pathways for Tricuspid Valve Stenosis

GO Terms for Tricuspid Valve Stenosis

Cellular components related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.26 GJA1 JAG1 NOTCH1 OXTR
2 Golgi membrane GO:0000139 9.02 CD59 GJA1 NOTCH1 SERPINA1 SNAPIN

Biological processes related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 Notch signaling pathway GO:0007219 9.77 HEY2 JAG1 NOTCH1
2 neuronal stem cell population maintenance GO:0097150 9.62 JAG1 NOTCH1
3 positive regulation of blood pressure GO:0045777 9.62 ENSG00000264813 OXTR
4 aortic valve morphogenesis GO:0003180 9.61 JAG1 NOTCH1
5 embryonic heart tube development GO:0035050 9.61 GJA1 NKX2-6
6 ventricular trabecula myocardium morphogenesis GO:0003222 9.59 HEY2 NOTCH1
7 cardiac right ventricle morphogenesis GO:0003215 9.58 HEY2 JAG1
8 negative regulation of stem cell differentiation GO:2000737 9.58 JAG1 NOTCH1
9 cardiac epithelial to mesenchymal transition GO:0060317 9.57 HEY2 NOTCH1
10 endocardial cushion development GO:0003197 9.56 CRELD1 NOTCH1
11 response to muramyl dipeptide GO:0032495 9.55 JAG1 NOTCH1
12 cardiac left ventricle morphogenesis GO:0003214 9.54 HEY2 NOTCH1
13 cardiac ventricle morphogenesis GO:0003208 9.52 HEY2 NOTCH1
14 ventricular cardiac muscle cell development GO:0055015 9.51 HEY2 NKX2-6
15 mesenchymal cell development GO:0014031 9.49 HEY2 NOTCH1
16 pulmonary artery morphogenesis GO:0061156 9.48 HEY2 JAG1
17 regulation of inner ear auditory receptor cell differentiation GO:0045607 9.46 HEY2 NOTCH1
18 arterial endothelial cell differentiation GO:0060842 9.43 HEY2 NOTCH1
19 pulmonary valve morphogenesis GO:0003184 9.43 HEY2 JAG1 NOTCH1
20 cardiac vascular smooth muscle cell development GO:0060948 9.4 HEY2 NOTCH1
21 distal tubule development GO:0072017 9.37 JAG1 NOTCH1
22 cardiac septum morphogenesis GO:0060411 9.33 HEY2 JAG1 NOTCH1
23 positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 9.32 JAG1 NOTCH1
24 Notch signaling involved in heart development GO:0061314 9.13 HEY2 JAG1 NOTCH1
25 heart development GO:0007507 9.1 FBN1 GJA1 HEY2 NKX2-6 NOTCH1 OXTR

Molecular functions related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch binding GO:0005112 8.62 JAG1 NOTCH1

Sources for Tricuspid Valve Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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