MCID: TRC021
MIFTS: 42

Tricuspid Valve Stenosis

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Tricuspid Valve Stenosis

MalaCards integrated aliases for Tricuspid Valve Stenosis:

Name: Tricuspid Valve Stenosis 12 45 15 17 74
Tricuspid Stenosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4078
MeSH 45 D014264
NCIt 51 C50783
SNOMED-CT 69 49915006
ICD10 34 I07.0 I07.2
UMLS 74 C0040963

Summaries for Tricuspid Valve Stenosis

Disease Ontology : 12 A tricuspid valve disease that is characterized by the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve.

MalaCards based summary : Tricuspid Valve Stenosis, also known as tricuspid stenosis, is related to tricuspid valve insufficiency and tricuspid valve disease. An important gene associated with Tricuspid Valve Stenosis is HEY2 (Hes Related Family BHLH Transcription Factor With YRPW Motif 2), and among its related pathways/superpathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Sevoflurane and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include heart and colon, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Tricuspid Valve Stenosis is a valvular heart disease that narrows the opening of the heart''s tricuspid... more...

Related Diseases for Tricuspid Valve Stenosis

Diseases related to Tricuspid Valve Stenosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 tricuspid valve insufficiency 30.7 ARSE CA6
2 tricuspid valve disease 30.1 ARSE HEY2
3 congenital tricuspid stenosis 12.5
4 tricuspid atresia 10.8
5 endocarditis 10.3
6 tricuspid valve agenesis 10.3
7 pericarditis 10.2
8 infective endocarditis 10.2
9 constrictive pericarditis 10.1
10 mitral valve stenosis 10.1
11 nodular regenerative hyperplasia 10.1 JAG1 NOTCH1
12 rheumatic heart disease 10.1
13 radial neuropathy 10.1 NOTCH1 SERPINA1
14 ossifying fibroma 10.1 JAG1 NOTCH1
15 alagille syndrome 1 10.0 HEY2 JAG1 NOTCH1
16 fibroma 10.0
17 antiphospholipid syndrome 10.0
18 rere-related disorders 10.0
19 aneurysm of sinus of valsalva 10.0
20 transposition of the great arteries, dextro-looped 1 10.0
21 end stage renal failure 10.0
22 lymphoma 10.0
23 sarcoma 10.0
24 heart disease 10.0
25 cardiac tamponade 10.0
26 atrial heart septal defect 10.0
27 lutembacher's syndrome 10.0
28 situs inversus 10.0
29 double discordia 10.0
30 double outlet right atrium 10.0
31 interatrial communication 10.0
32 levocardia 10.0
33 carcinoid tumors, intestinal 10.0 NOTCH1 SST
34 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 9.9 JAG1 NOTCH1
35 pancreatoblastoma 9.9 SERPINA1 SST
36 functional colonic disease 9.9 CD59 SST
37 systemic lupus erythematosus 9.8
38 rheumatoid arthritis 9.8
39 ebstein anomaly 9.8
40 endocardial fibroelastosis 9.8
41 hypoplastic left heart syndrome 1 9.8
42 myocardial infarction 9.8
43 cholangitis, primary sclerosing 9.8
44 lymphatic malformation 7 9.8
45 acute myocardial infarction 9.8
46 heart valve disease 9.8
47 hypoplastic left heart syndrome 9.8
48 angiosarcoma 9.8
49 atrial fibrillation 9.8
50 patent foramen ovale 9.8

Graphical network of the top 20 diseases related to Tricuspid Valve Stenosis:



Diseases related to Tricuspid Valve Stenosis

Symptoms & Phenotypes for Tricuspid Valve Stenosis

GenomeRNAi Phenotypes related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.44 CD59
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.44 NOTCH1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-150 9.44 CD59
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 CD59
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.44 HEY2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 CD59
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.44 HEY2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.44 CD59
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.44 HEY2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.44 CD59 HEY2 NOTCH1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.44 NOTCH1

MGI Mouse Phenotypes related to Tricuspid Valve Stenosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.9 BUB1B CD59 GJA1 HEY2 JAG1 NOTCH1
2 cardiovascular system MP:0005385 9.86 BUB1B GJA1 HEY2 JAG1 NOTCH1 PPIA
3 muscle MP:0005369 9.5 BUB1B GJA1 HEY2 JAG1 NOTCH1 OXTR
4 nervous system MP:0003631 9.28 GJA1 HEY2 JAG1 NOTCH1 OXTR SLC6A11

Drugs & Therapeutics for Tricuspid Valve Stenosis

Drugs for Tricuspid Valve Stenosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved 28523-86-6 5206
2 Anesthetics
3 Anesthetics, Inhalation
4 Anesthetics, General
5 Platelet Aggregation Inhibitors
6 Central Nervous System Depressants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Determine the Effective Dose 95 of Sevoflurane in Adult Patients Recruiting NCT02711384

Search NIH Clinical Center for Tricuspid Valve Stenosis

Cochrane evidence based reviews: tricuspid valve stenosis

Genetic Tests for Tricuspid Valve Stenosis

Anatomical Context for Tricuspid Valve Stenosis

MalaCards organs/tissues related to Tricuspid Valve Stenosis:

42
Heart, Colon

Publications for Tricuspid Valve Stenosis

Articles related to Tricuspid Valve Stenosis:

(show top 50) (show all 259)
# Title Authors Year
1
A Giant Right Coronary Artery Aneurysm leading to Tricuspid Stenosis. ( 30872099 )
2019
2
Valvular heart disease in Antiphospholipid antibody syndrome: Isolated Tricuspid stenosis. ( 30614053 )
2019
3
Large Primary Cardiac Lymphoma Causing Functional Tricuspid Valve Stenosis. ( 30374246 )
2018
4
Tricuspid stenosis: A rare and potential complication of ventricular septal occluder device. ( 29652285 )
2018
5
An Unusual Case of Tricuspid Stenosis. ( 30756028 )
2018
6
Percutaneous Valvuloplasty for Bioprosthetic Tricuspid Valve Stenosis. ( 28265212 )
2017
7
Functional tricuspid stenosis: a rare presentation of suspected rhabdomyoma as congenital cyanotic heart disease. ( 28077182 )
2017
8
Balloon Valvuloplasty of Tricuspid Stenosis: A Retrospective Study of 5 Labrador Retriever Dogs. ( 28220526 )
2017
9
Surgical management of tricuspid stenosis. ( 28706872 )
2017
10
Case Image: Unruptured non-coronary sinus of Valsalva aneurysm presenting with nausea secondary to functional tricuspid stenosis. ( 29226903 )
2017
11
Tricuspid stenosis: An emerging disease in cardiac implantable electronic devices era. Case report and literature review. ( 30279777 )
2017
12
Functional Tricuspid Stenosis in Primary Sclerosing Cholangitis: A Case Report. ( 26903307 )
2016
13
Right atrial spindle cell sarcoma as a rare cause of tricuspid stenosis. ( 27436036 )
2016
14
Letter by Tunçez et al Regarding Article, "The Forgotten Valve: Isolated Severe Tricuspid Valve Stenosis". ( 26903023 )
2016
15
An unusual cause of severe tricuspid stenosis. ( 26875140 )
2016
16
Severe Functional Tricuspid Stenosis Secondary to a Giant Saphenous Vein Bypass Graft Aneurysm. ( 27217436 )
2016
17
Percutaneous valvuloplasty for severe bioprosthetic tricuspid valve stenosis in the setting of infective endocarditis. ( 24399759 )
2015
18
Reversible tricuspid valve stenosis induced by ascending aorta aneurysm: an image focus. ( 25706906 )
2015
19
Percutaneous transcatheter balloon valvuloplasty for bioprosthetic tricuspid valve stenosis in a patient with orthotopic heart transplant. ( 25740974 )
2015
20
Acquired tricuspid valve stenosis associated with two ventricular endocardial pacing leads in a dog. ( 25955141 )
2015
21
Giant right atrium due to rheumatic tricuspid valve stenosis. ( 26005174 )
2015
22
The Forgotten Valve: Isolated Severe Tricuspid Valve Stenosis. ( 26283605 )
2015
23
Acquired tricuspid valve stenosis due to intentionally redundant transvenous lead placement for VDD pacing in two small dogs. ( 26463216 )
2015
24
Balloon dilatation of isolated severe tricuspid valve stenosis. ( 26995441 )
2015
25
Transesophageal echocardiographic diagnosis of severe functional tricuspid stenosis during infected implantable cardioverter-defibrillator lead extraction. ( 25440647 )
2015
26
Right atrial myxoma mimicking tricuspid stenosis. ( 26272962 )
2015
27
Thrombotic Obstruction of a Melody Valve-in-Valve Used for Prosthetic Tricuspid Stenosis. ( 26467885 )
2015
28
Neonatal tricuspid stenosis caused by device closure of a large coronary fistula. ( 26603866 )
2015
29
Asymptomatic Tricuspid Stenosis Following a Complex Lead Extraction Procedure. ( 26901908 )
2015
30
Percutaneous tricuspid valvotomy for pacemaker lead-induced tricuspid stenosis. ( 26995417 )
2015
31
Amyloidosis-induced tricuspid stenosis mimicking rheumatic heart disease. ( 24797117 )
2014
32
Inoue balloon valvuloplasty for rheumatic tricuspid valve stenosis: an excellent technique with some intrinsic difficulties. ( 23756413 )
2014
33
Balloon valvuloplasty for bioprosthetic tricuspid valve stenosis. ( 24653745 )
2014
34
Dynamic tricuspid valve stenosis induced with a pacemaker lead: a case report. ( 24779342 )
2014
35
Isolated tricuspid valve stenosis--probably of rheumatic etiology. ( 25672046 )
2014
36
Percutaneous balloon valvotomy for the treatment of pacemaker lead-induced tricuspid stenosis. ( 24052372 )
2014
37
Pacemaker lead-related tricuspid stenosis successfully treated with percutaneous balloon valvuloplasty guided by 3D echocardiography. ( 25455950 )
2014
38
Pacemaker lead-induced severe tricuspid valve stenosis: complete percutaneous extraction under extracorporeal life support. ( 23515340 )
2013
39
Repair of rheumatic tricuspid valve stenosis with autologous pericardium. ( 23958528 )
2013
40
How should I treat prosthetic tricuspid stenosis in an extreme surgical risk patient? ( 23872655 )
2013
41
A fetus with hypoplastic left heart syndrome and tricuspid stenosis with evolving hydrops fetalis. ( 22398637 )
2012
42
Bioprosthetic tricuspid valve stenosis in end-stage renal failure. ( 22104429 )
2012
43
Early prenatal diagnosis of tricuspid stenosis. ( 22964066 )
2012
44
Situs inversus with levocardia and congenitally corrected transposition of great vessels with rheumatic tricuspid valve stenosis and regurgitation. ( 22574246 )
2011
45
Platypnea-orthodeoxia syndrome associated with bioprosthetic tricuspid valve stenosis and reverse Lutembacher syndrome. ( 21300958 )
2011
46
Giant saphenous vein graft pseudoaneurysm causing tricuspid valve stenosis. ( 21332791 )
2011
47
Unusual case of colonized pacemaker lead presenting with endocarditis, hemoptysis and tricuspid valve stenosis. ( 21766083 )
2011
48
Aseptic Endocarditis in Behçet's Disease Presenting as Tricuspid Valve Stenosis. ( 21860642 )
2011
49
Valvuloplasty for tricuspid stenosis caused by a ventriculoatrial shunt. ( 20824751 )
2011
50
Balloon valvuloplasty of a tricuspid valve stenosis in double balloon technique. ( 20049464 )
2010

Variations for Tricuspid Valve Stenosis

Expression for Tricuspid Valve Stenosis

Search GEO for disease gene expression data for Tricuspid Valve Stenosis.

Pathways for Tricuspid Valve Stenosis

GO Terms for Tricuspid Valve Stenosis

Cellular components related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 focal adhesion GO:0005925 9.56 CD59 GJA1 PPIA YWHAE
2 extracellular region GO:0005576 9.56 CA6 CD59 IL4I1 JAG1 NOTCH1 PPIA
3 apical plasma membrane GO:0016324 9.46 GJA1 JAG1 NOTCH1 OXTR
4 Golgi membrane GO:0000139 9.02 CD59 GJA1 NOTCH1 SERPINA1 SNAPIN

Biological processes related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.8 GJA1 HEY2 NOTCH1 OXTR
2 Notch signaling pathway GO:0007219 9.76 HEY2 JAG1 NOTCH1
3 positive regulation of vasoconstriction GO:0045907 9.62 GJA1 OXTR
4 response to steroid hormone GO:0048545 9.61 OXTR SST
5 positive regulation of viral genome replication GO:0045070 9.61 NOTCH1 PPIA
6 neuronal stem cell population maintenance GO:0097150 9.6 JAG1 NOTCH1
7 aortic valve morphogenesis GO:0003180 9.59 JAG1 NOTCH1
8 ventricular trabecula myocardium morphogenesis GO:0003222 9.58 HEY2 NOTCH1
9 cardiac right ventricle morphogenesis GO:0003215 9.57 HEY2 JAG1
10 negative regulation of stem cell differentiation GO:2000737 9.56 JAG1 NOTCH1
11 cardiac epithelial to mesenchymal transition GO:0060317 9.55 HEY2 NOTCH1
12 response to muramyl dipeptide GO:0032495 9.54 JAG1 NOTCH1
13 cardiac left ventricle morphogenesis GO:0003214 9.52 HEY2 NOTCH1
14 cardiac ventricle morphogenesis GO:0003208 9.51 HEY2 NOTCH1
15 mesenchymal cell development GO:0014031 9.48 HEY2 NOTCH1
16 pulmonary artery morphogenesis GO:0061156 9.46 HEY2 JAG1
17 regulation of inner ear auditory receptor cell differentiation GO:0045607 9.43 HEY2 NOTCH1
18 arterial endothelial cell differentiation GO:0060842 9.4 HEY2 NOTCH1
19 cardiac vascular smooth muscle cell development GO:0060948 9.37 HEY2 NOTCH1
20 pulmonary valve morphogenesis GO:0003184 9.33 HEY2 JAG1 NOTCH1
21 distal tubule development GO:0072017 9.32 JAG1 NOTCH1
22 positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 9.26 JAG1 NOTCH1
23 cardiac septum morphogenesis GO:0060411 9.13 HEY2 JAG1 NOTCH1
24 Notch signaling involved in heart development GO:0061314 8.8 HEY2 JAG1 NOTCH1

Molecular functions related to Tricuspid Valve Stenosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Notch binding GO:0005112 8.62 JAG1 NOTCH1

Sources for Tricuspid Valve Stenosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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