MCID: TRG003
MIFTS: 34

Trigeminal Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Trigeminal Nerve Disease

MalaCards integrated aliases for Trigeminal Nerve Disease:

Name: Trigeminal Nerve Disease 12 15 17
Trigeminal Nerve Diseases 74

Classifications:



External Ids:

Disease Ontology 12 DOID:561
ICD9CM 36 350.8
ICD10 34 G50 G50.8

Summaries for Trigeminal Nerve Disease

MalaCards based summary : Trigeminal Nerve Disease, also known as trigeminal nerve diseases, is related to sodium channelopathy-related small fiber neuropathy and indifference to pain, congenital, autosomal recessive, and has symptoms including neurologic symptoms and atypical facial pain. An important gene associated with Trigeminal Nerve Disease is MBD1 (Methyl-CpG Binding Domain Protein 1), and among its related pathways/superpathways are Neuroscience and L1CAM interactions. The drugs Ketamine and Ondansetron have been mentioned in the context of this disorder. Affiliated tissues include pons, testes and cortex, and related phenotype is behavior/neurological.

Wikipedia : 77 The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in... more...

Related Diseases for Trigeminal Nerve Disease

Graphical network of the top 20 diseases related to Trigeminal Nerve Disease:



Diseases related to Trigeminal Nerve Disease

Symptoms & Phenotypes for Trigeminal Nerve Disease

UMLS symptoms related to Trigeminal Nerve Disease:


neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Trigeminal Nerve Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.17 CRLF1 JMJD6 MBD1 MSTN SCN11A SCN3A

Drugs & Therapeutics for Trigeminal Nerve Disease

Drugs for Trigeminal Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Ondansetron Approved Phase 4 99614-02-5 4595
3
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
4
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
5
Oxcarbazepine Approved Phase 4 28721-07-5 34312
6 Dermatologic Agents Phase 4,Not Applicable
7 Antipsychotic Agents Phase 4,Phase 2,Phase 3,Not Applicable
8 Analgesics, Opioid Phase 4
9 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
10 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
11 Serotonin Antagonists Phase 4
12 Excitatory Amino Acids Phase 4,Phase 2
13 Narcotics Phase 4
14 Anesthetics Phase 4,Phase 2,Not Applicable
15 Excitatory Amino Acid Antagonists Phase 4,Phase 2
16 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
17 Anesthetics, Intravenous Phase 4
18 Anesthetics, Dissociative Phase 4
19 Gastrointestinal Agents Phase 4
20 Antipruritics Phase 4
21 Antiemetics Phase 4
22 Tranquilizing Agents Phase 4,Phase 2,Phase 3,Not Applicable
23 Psychotropic Drugs Phase 4,Phase 2,Phase 3,Not Applicable
24 Autonomic Agents Phase 4
25 Anti-Anxiety Agents Phase 4
26 Adjuvants, Anesthesia Phase 4
27 Serotonin Agents Phase 4
28 Anesthetics, General Phase 4
29 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
30 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Not Applicable
31 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Not Applicable
32 Sodium Channel Blockers Phase 4,Phase 2,Phase 3,Not Applicable
33 Anticonvulsants Phase 4,Phase 2,Phase 3,Not Applicable
34
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
35
Carbamazepine Approved, Investigational Phase 2, Phase 3,Not Applicable 298-46-4 2554
36
Lamotrigine Approved, Investigational Phase 2, Phase 3,Not Applicable 84057-84-1 3878
37
Acetylcholine Approved, Investigational Phase 3,Phase 1,Phase 2 51-84-3 187
38
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
39
Calcium Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 7440-70-2 271
40 Calcium, Dietary Phase 2, Phase 3,Not Applicable
41 Hormones Phase 2, Phase 3,Not Applicable
42 Analgesics, Non-Narcotic Phase 2, Phase 3,Not Applicable
43 calcium channel blockers Phase 2, Phase 3,Not Applicable
44 Antimanic Agents Phase 2, Phase 3,Not Applicable
45 abobotulinumtoxinA Phase 3,Phase 1,Phase 2
46 Acetylcholine Release Inhibitors Phase 3,Phase 1,Phase 2
47 Botulinum Toxins, Type A Phase 3,Phase 1,Phase 2
48 Botulinum Toxins Phase 3,Phase 1,Phase 2
49 Neuromuscular Agents Phase 3,Phase 1,Phase 2
50 Cholinergic Agents Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Postoperative Analgesia in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
2 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
3 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
4 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
5 Botulinum Toxin Injections for Oral Neuropathic Pain Recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
6 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
7 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
8 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
9 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
10 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
11 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
12 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
13 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
14 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
15 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
16 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
17 Trial for Treatment Refractory Trigeminal Neuralgia Recruiting NCT03941834 Phase 2 Rimegepant;Placebo
18 Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy Not yet recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
19 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Terminated NCT02624661 Phase 1, Phase 2 Glycerol
20 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
21 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
22 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
23 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
24 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
25 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630 Not Applicable
26 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
27 Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury Unknown status NCT01586598 Not Applicable
28 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
29 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
30 Prognosis of Trigeminal Neuralgia When Enrolled in a Multidisciplinary Management Program Completed NCT03838393
31 Classical Trigeminal Neuralgia and Sodium Channel Mutations Completed NCT03656497
32 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia Completed NCT03549013
33 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406 Not Applicable
34 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
35 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Not Applicable Lidocaine
36 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Completed NCT01761604 Not Applicable
37 Hippocampal Radiation Exposure and Memory Completed NCT00603694
38 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807 Not Applicable
39 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 Not Applicable lamotrigine;Placebo
40 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 Not Applicable L-baclofen
41 Neurophysiologic Signatures of Trigeminal Neuralgia Pain Recruiting NCT03778177 Not Applicable
42 Phenytoin as Treatment for Acute Exacerbations of Trigeminal Neuralgia - a Prospective Systematic Study of 20 Patients Recruiting NCT03712254 Fosphenytoin
43 Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital Recruiting NCT03669744
44 Neurosurgical Transitional Care Programme Recruiting NCT03593330 Not Applicable
45 High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia Recruiting NCT03131466 Not Applicable Nerve block
46 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323
47 An Follow-up Study of Occlusal Adjustment for Orofacial Pain Recruiting NCT02856906 Not Applicable
48 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810 Not Applicable
49 Bilateral TMS vs. Unilateral TMS Active, not recruiting NCT03710967 Not Applicable
50 Transcranial Magnetic Stimulation for Facial Pain Active, not recruiting NCT02633306 Not Applicable

Search NIH Clinical Center for Trigeminal Nerve Disease

Genetic Tests for Trigeminal Nerve Disease

Anatomical Context for Trigeminal Nerve Disease

MalaCards organs/tissues related to Trigeminal Nerve Disease:

42
Pons, Testes, Cortex, Trigeminal Ganglion

Publications for Trigeminal Nerve Disease

Articles related to Trigeminal Nerve Disease:

# Title Authors Year
1
Evoked taste thresholds in a normal population and the application of electrogustometry to trigeminal nerve disease. ( 3819752 )
1987

Variations for Trigeminal Nerve Disease

Expression for Trigeminal Nerve Disease

Search GEO for disease gene expression data for Trigeminal Nerve Disease.

Pathways for Trigeminal Nerve Disease

Pathways related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 CALCA SCN11A SCN9A
2
Show member pathways
11.43 SCN11A SCN3A SCN9A
3
Show member pathways
11.01 SCN11A SCN3A SCN9A
4 10.28 SCN11A SCN3A SCN9A

GO Terms for Trigeminal Nerve Disease

Cellular components related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.13 SCN11A SCN3A SCN9A
2 voltage-gated sodium channel complex GO:0001518 8.8 SCN11A SCN3A SCN9A

Biological processes related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.5 SCN11A SCN3A SCN9A
2 sodium ion transport GO:0006814 9.43 SCN11A SCN3A SCN9A
3 sodium ion transmembrane transport GO:0035725 9.33 SCN11A SCN3A SCN9A
4 neuronal action potential GO:0019228 9.13 SCN11A SCN3A SCN9A
5 response to heat GO:0009408 9.07 MSTN
6 membrane depolarization during action potential GO:0086010 8.8 SCN11A SCN3A SCN9A

Molecular functions related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.43 SCN11A SCN3A SCN9A
2 voltage-gated ion channel activity GO:0005244 9.33 SCN11A SCN3A SCN9A
3 sodium channel activity GO:0005272 9.13 SCN11A SCN3A SCN9A
4 voltage-gated sodium channel activity GO:0005248 8.8 SCN11A SCN3A SCN9A

Sources for Trigeminal Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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