MCID: TRG003
MIFTS: 35

Trigeminal Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Trigeminal Nerve Disease

MalaCards integrated aliases for Trigeminal Nerve Disease:

Name: Trigeminal Nerve Disease 12 15 17
Trigeminal Nerve Diseases 74

Classifications:



External Ids:

Disease Ontology 12 DOID:561
ICD9CM 36 350.8
ICD10 34 G50 G50.8

Summaries for Trigeminal Nerve Disease

MalaCards based summary : Trigeminal Nerve Disease, also known as trigeminal nerve diseases, is related to sodium channelopathy-related small fiber neuropathy and indifference to pain, congenital, autosomal recessive, and has symptoms including neurologic symptoms and atypical facial pain. An important gene associated with Trigeminal Nerve Disease is MBD1 (Methyl-CpG Binding Domain Protein 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Neuroscience. The drugs Ropivacaine and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include pons, testes and cortex, and related phenotype is behavior/neurological.

Wikipedia : 77 The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in... more...

Related Diseases for Trigeminal Nerve Disease

Graphical network of the top 20 diseases related to Trigeminal Nerve Disease:



Diseases related to Trigeminal Nerve Disease

Symptoms & Phenotypes for Trigeminal Nerve Disease

UMLS symptoms related to Trigeminal Nerve Disease:


neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Trigeminal Nerve Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.17 CRLF1 JMJD6 MBD1 SCN11A SCN3A SCN9A

Drugs & Therapeutics for Trigeminal Nerve Disease

Drugs for Trigeminal Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
2
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Ondansetron Approved Phase 4 99614-02-5 4595
5
Oxcarbazepine Approved Phase 4 28721-07-5 34312
6 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
7 Antipsychotic Agents Phase 4,Phase 2,Phase 3,Not Applicable
8 Excitatory Amino Acids Phase 4,Phase 2
9 Tranquilizing Agents Phase 4,Phase 2,Phase 3,Not Applicable
10 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Analgesics, Opioid Phase 4
13 Excitatory Amino Acid Antagonists Phase 4,Phase 2
14 Psychotropic Drugs Phase 4,Phase 2,Phase 3,Not Applicable
15 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
16 Anesthetics Phase 4,Phase 2,Not Applicable
17 Sodium Channel Blockers Phase 4,Phase 2,Phase 3,Not Applicable
18 Anticonvulsants Phase 4,Phase 2,Phase 3,Not Applicable
19 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Not Applicable
20 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Not Applicable
21 Dermatologic Agents Phase 4,Not Applicable
22 Adjuvants, Anesthesia Phase 4
23 Antiemetics Phase 4
24 Anti-Anxiety Agents Phase 4
25 Antipruritics Phase 4
26 Anesthetics, General Phase 4
27 Gastrointestinal Agents Phase 4
28 Autonomic Agents Phase 4
29 Anesthetics, Dissociative Phase 4
30 Anesthetics, Intravenous Phase 4
31 Narcotics Phase 4
32 Serotonin Agents Phase 4
33 Serotonin Antagonists Phase 4
34
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
35
Carbamazepine Approved, Investigational Phase 2, Phase 3,Not Applicable 298-46-4 2554
36
Lamotrigine Approved, Investigational Phase 2, Phase 3,Not Applicable 84057-84-1 3878
37
Acetylcholine Approved, Investigational Phase 3,Phase 1,Phase 2 51-84-3 187
38
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
39
Calcium Approved, Nutraceutical Phase 2, Phase 3,Not Applicable 7440-70-2 271
40 Calcium, Dietary Phase 2, Phase 3,Not Applicable
41 Analgesics, Non-Narcotic Phase 2, Phase 3,Not Applicable
42 Hormones Phase 2, Phase 3,Not Applicable
43 calcium channel blockers Phase 2, Phase 3,Not Applicable
44 Antimanic Agents Phase 2, Phase 3,Not Applicable
45 Neuromuscular Agents Phase 3,Phase 1,Phase 2
46 Botulinum Toxins Phase 3,Phase 1,Phase 2
47 abobotulinumtoxinA Phase 3,Phase 1,Phase 2
48 Cholinergic Agents Phase 3,Phase 1,Phase 2
49 Acetylcholine Release Inhibitors Phase 3,Phase 1,Phase 2
50 Botulinum Toxins, Type A Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
2 Postoperative Analgesia in Patients With Microvascular Decompression Active, not recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
3 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
4 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
5 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
6 Botulinum Toxin Injections for Oral Neuropathic Pain Not yet recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
7 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
8 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
9 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
10 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
11 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
12 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
13 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
14 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
15 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
16 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
17 Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy Not yet recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
18 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Terminated NCT02624661 Phase 1, Phase 2 Glycerol
19 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
20 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
21 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
22 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
23 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
24 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630 Not Applicable
25 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
26 Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury Unknown status NCT01586598 Not Applicable
27 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
28 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
29 Prognosis of Trigeminal Neuralgia When Enrolled in a Multidisciplinary Management Program Completed NCT03838393
30 Classical Trigeminal Neuralgia and Sodium Channel Mutations Completed NCT03656497
31 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia Completed NCT03549013
32 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406 Not Applicable
33 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
34 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Not Applicable Lidocaine
35 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Completed NCT01761604 Not Applicable
36 Hippocampal Radiation Exposure and Memory Completed NCT00603694
37 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807 Not Applicable
38 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 Not Applicable lamotrigine;Placebo
39 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 Not Applicable L-baclofen
40 Neurophysiologic Signatures of Trigeminal Neuralgia Pain Recruiting NCT03778177 Not Applicable
41 Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital Recruiting NCT03669744
42 Neurosurgical Transitional Care Programme Recruiting NCT03593330 Not Applicable
43 High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia Recruiting NCT03131466 Not Applicable Nerve block
44 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323
45 An Follow-up Study of Occlusal Adjustment for Orofacial Pain Recruiting NCT02856906 Not Applicable
46 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810 Not Applicable
47 Bilateral TMS vs. Unilateral TMS Active, not recruiting NCT03710967 Not Applicable
48 Transcranial Magnetic Stimulation for Facial Pain Active, not recruiting NCT02633306 Not Applicable
49 Comparison Between Radiofrequency and Balloon Compression in the Treatment of Idiopathic Trigeminal Neuralgia Active, not recruiting NCT02427074 Not Applicable
50 RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT Enrolling by invitation NCT01885299

Search NIH Clinical Center for Trigeminal Nerve Disease

Genetic Tests for Trigeminal Nerve Disease

Anatomical Context for Trigeminal Nerve Disease

MalaCards organs/tissues related to Trigeminal Nerve Disease:

42
Pons, Testes, Cortex, Trigeminal Ganglion

Publications for Trigeminal Nerve Disease

Articles related to Trigeminal Nerve Disease:

# Title Authors Year
1
Evoked taste thresholds in a normal population and the application of electrogustometry to trigeminal nerve disease. ( 3819752 )
1987

Variations for Trigeminal Nerve Disease

Expression for Trigeminal Nerve Disease

Search GEO for disease gene expression data for Trigeminal Nerve Disease.

Pathways for Trigeminal Nerve Disease

Pathways related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.05 SCN11A SCN3A SCN9A TAC1
2 12.03 CALCA SCN11A SCN9A
3
Show member pathways
11.53 SCN11A SCN3A SCN9A
4
Show member pathways
11.01 SCN11A SCN3A SCN9A
5 10.28 SCN11A SCN3A SCN9A

GO Terms for Trigeminal Nerve Disease

Cellular components related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.35 CALCA SCN11A SCN3A SCN9A TAC1
2 voltage-gated sodium channel complex GO:0001518 8.8 SCN11A SCN3A SCN9A

Biological processes related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.54 SCN11A SCN3A SCN9A
2 regulation of blood pressure GO:0008217 9.46 CALCA TAC1
3 sensory perception of pain GO:0019233 9.43 SCN9A TAC1
4 sodium ion transport GO:0006814 9.43 SCN11A SCN3A SCN9A
5 cellular response to nerve growth factor stimulus GO:1990090 9.4 CALCA TAC1
6 sodium ion transmembrane transport GO:0035725 9.33 SCN11A SCN3A SCN9A
7 response to pain GO:0048265 9.32 CALCA TAC1
8 neuronal action potential GO:0019228 9.13 SCN11A SCN3A SCN9A
9 membrane depolarization during action potential GO:0086010 8.8 SCN11A SCN3A SCN9A

Molecular functions related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.43 SCN11A SCN3A SCN9A
2 voltage-gated ion channel activity GO:0005244 9.33 SCN11A SCN3A SCN9A
3 sodium channel activity GO:0005272 9.13 SCN11A SCN3A SCN9A
4 voltage-gated sodium channel activity GO:0005248 8.8 SCN11A SCN3A SCN9A

Sources for Trigeminal Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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