MCID: TRG003
MIFTS: 36

Trigeminal Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Trigeminal Nerve Disease

MalaCards integrated aliases for Trigeminal Nerve Disease:

Name: Trigeminal Nerve Disease 12 15 17
Trigeminal Nerve Diseases 71

Classifications:



External Ids:

Disease Ontology 12 DOID:561
ICD9CM 34 350.8
ICD10 32 G50 G50.8 G50.9
UMLS 71 C0029834 C0152177

Summaries for Trigeminal Nerve Disease

MalaCards based summary : Trigeminal Nerve Disease, also known as trigeminal nerve diseases, is related to trigeminal neuralgia and facial neuralgia, and has symptoms including neurologic symptoms and atypical facial pain. An important gene associated with Trigeminal Nerve Disease is ANTXR2 (ANTXR Cell Adhesion Molecule 2), and among its related pathways/superpathways are Peptide ligand-binding receptors and Cardiac conduction. The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include pons, cortex and testes, and related phenotypes are behavior/neurological and integument

Wikipedia : 74 The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in... more...

Related Diseases for Trigeminal Nerve Disease

Diseases related to Trigeminal Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 trigeminal neuralgia 24.7 TRPV1 TRPA1 TAC1 SCN9A SCN8A SCN3A
2 facial neuralgia 10.5 MBD1 CRLF1
3 petrous apex meningioma 10.5 KANTR ANTXR2
4 cerebral falx meningioma 10.5 KANTR ANTXR2
5 foramen magnum meningioma 10.5 KANTR ANTXR2
6 telogen effluvium 10.4 TAC1 ANTXR2
7 neurogenic arthropathy 10.4 SCN9A CALCA
8 arachnoiditis 10.4 TAC1 CRLF1
9 neurodermatitis 10.4 TAC1 KANTR
10 glossopharyngeal neuralgia 10.4 KANTR CRLF1 ANTXR2
11 glossopharyngeal nerve disease 10.4 KANTR CRLF1 ANTXR2
12 cough variant asthma 10.4 TRPV1 TAC1
13 retinitis pigmentosa 68 10.4 TAC1 NPS
14 intracranial hypotension 10.4 MBD1 CRLF1
15 facial nerve disease 10.3 KANTR CRLF1 ANTXR2
16 photokeratitis 10.3 TRPV1 TRPA1
17 familial episodic pain syndrome 10.3 TRPA1 SCN11A
18 subungual glomus tumor 10.3 TRPV1 TAC1
19 carbamazepine allergy 10.3 TAC1 NPS CALCA
20 complex regional pain syndrome 10.3 TAC1 SCN9A CALCA
21 perianal hematoma 10.3 TAC1 NPS CALCA
22 sodium channelopathy-related small fiber neuropathy 10.3 SCN9A SCN11A SCN10A
23 causalgia 10.3 TAC1 NPS CALCA
24 dentin sensitivity 10.3 TRPV1 TRPA1
25 indifference to pain, congenital, autosomal recessive 10.3 SCN9A SCN11A SCN10A
26 epicondylitis 10.3 TAC1 NPS CALCA
27 reflex sympathetic dystrophy 10.3 TAC1 NPS CALCA
28 progressive familial heart block, type ib 10.3 TRPV1 TRPA1
29 progressive familial heart block, type ia 10.3 SCN9A SCN8A SCN3A
30 erythermalgia, primary 10.3 SCN9A SCN11A SCN10A
31 cystitis 10.3 TRPV1 TAC1 P2RX3
32 aids phobia 10.3 TAC1 SCN11A NPS
33 detrusor sphincter dyssynergia 10.3 TRPV1 TAC1 P2RX3
34 neuropathy, hereditary sensory and autonomic, type vii 10.3 SCN3A SCN11A SCN10A
35 pulpitis 10.2 TRPV1 TAC1 SCN8A
36 neonatal period electroclinical syndrome 10.2 SCN9A SCN8A SCN3A
37 chronic cystitis 10.2 TRPV1 TAC1 P2RX3
38 neurogenic bladder 10.2 TRPV1 TAC1 P2RX3
39 neuroma 10.2 TRPV1 SCN10A CALCA
40 sick building syndrome 10.2 TRPV1 TRPA1
41 lennox-gastaut syndrome 10.2 SCN9A SCN8A SCN3A
42 myofascial pain syndrome 10.2 TRPV1 TAC1 NPS CALCA
43 vasomotor rhinitis 10.2 TRPV1 TAC1 NPS CALCA
44 dental pulp disease 10.2 TRPV1 TAC1 NPS CALCA
45 paroxysmal extreme pain disorder 10.2 TRPV1 SCN9A SCN11A SCN10A
46 viral laryngitis 10.2 TRPV1 TRPA1
47 interstitial cystitis 10.1 TRPV1 TAC1 SCN9A P2RX3
48 low-grade astrocytoma 10.1 SCN8A SCN3A
49 polyradiculopathy 10.0 TRPV1 TAC1 SCN9A NPS CALCA
50 epileptic encephalopathy, early infantile, 6 10.0 SCN9A SCN8A SCN3A SCN11A

Graphical network of the top 20 diseases related to Trigeminal Nerve Disease:



Diseases related to Trigeminal Nerve Disease

Symptoms & Phenotypes for Trigeminal Nerve Disease

UMLS symptoms related to Trigeminal Nerve Disease:


neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Trigeminal Nerve Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 CRLF1 MBD1 OPRD1 OPRK1 OPRL1 OPRM1
2 integument MP:0010771 9.9 OPRD1 OPRK1 OPRL1 OPRM1 P2RX3 SCN10A
3 nervous system MP:0003631 9.77 CRLF1 MBD1 OPRD1 OPRK1 OPRL1 OPRM1
4 no phenotypic analysis MP:0003012 9.17 ANTXR2 OPRD1 OPRM1 SCN10A SCN3A TRPA1

Drugs & Therapeutics for Trigeminal Nerve Disease

Drugs for Trigeminal Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
2 Neurotransmitter Agents Phase 3
3 abobotulinumtoxinA Phase 3
4 Acetylcholine Release Inhibitors Phase 3
5 Pharmaceutical Solutions Phase 3
6 Neuromuscular Agents Phase 3
7 Cholinergic Agents Phase 3
8 Botulinum Toxins, Type A Phase 3
9 Botulinum Toxins Phase 3
10
Guanfacine Approved, Investigational Phase 2 29110-47-2 3519
11
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
12 Adrenergic alpha-2 Receptor Agonists Phase 2
13 Anti-Arrhythmia Agents Phase 2
14 Anesthetics, Local Phase 2
15 Adrenergic Agonists Phase 2
16 Sodium Channel Blockers Phase 2
17 Anesthetics Phase 2
18 Central Nervous System Depressants Phase 2
19 Diuretics, Potassium Sparing Phase 2
20 Adrenergic Agents Phase 2
21 Antihypertensive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Botulinum Toxin (BTX) for the Treatment of Peripheral Painful Traumatic Trigeminal Neuropathy (PPTTN) Recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
2 A Randomized, Double-Blind, 2-Way Crossover Trial to Assess the Efficacy of Guanfacine and Lidocaine Combination Versus Lidocaine Alone in Trigeminal Nerve Block for Pain Management in Painful Trigeminal Neuropathy Patients Recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
3 Bilateral vs. Unilateral Transcranial Magnetic Stimulation of the Primary Motor Cortex to Treat Chronic Orofacial Pain: a Pilot Study With a Randomized Controlled Design Active, not recruiting NCT03710967

Search NIH Clinical Center for Trigeminal Nerve Disease

Genetic Tests for Trigeminal Nerve Disease

Anatomical Context for Trigeminal Nerve Disease

MalaCards organs/tissues related to Trigeminal Nerve Disease:

40
Pons, Cortex, Testes

Publications for Trigeminal Nerve Disease

Articles related to Trigeminal Nerve Disease:

# Title Authors PMID Year
1
Magnetic resonance imaging contrast enhancement of the trigeminal nerve in dogs without evidence of trigeminal neuropathy. 61
19507390 2009
2
The effect of unilateral corneal anesthesia on the Schirmer test. 61
2501743 1989
3
Evoked taste thresholds in a normal population and the application of electrogustometry to trigeminal nerve disease. 61
3819752 1987

Variations for Trigeminal Nerve Disease

Expression for Trigeminal Nerve Disease

Search GEO for disease gene expression data for Trigeminal Nerve Disease.

Pathways for Trigeminal Nerve Disease

Pathways related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 TRPV1 TAC1 P2RX3 OPRM1 OPRL1 OPRK1
2
Show member pathways
12.53 SCN9A SCN8A SCN3A SCN11A SCN10A
3
Show member pathways
12.39 TAC1 SCN9A SCN8A SCN3A SCN11A SCN10A
4 12.27 SCN9A SCN8A SCN11A SCN10A OPRM1 CALCA
5
Show member pathways
11.7 SCN9A SCN3A P2RX3
6
Show member pathways
11.65 SCN9A SCN8A SCN3A SCN11A SCN10A
7
Show member pathways
11.23 SCN9A SCN8A SCN3A SCN11A SCN10A
8 10.5 SCN9A SCN8A SCN3A SCN11A SCN10A

GO Terms for Trigeminal Nerve Disease

Cellular components related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.25 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN11A
2 plasma membrane GO:0005886 10.1 TRPV1 TRPA1 TAC1 SCN9A SCN8A SCN3A
3 integral component of plasma membrane GO:0005887 9.97 TRPV1 TRPA1 SCN9A P2RX3 OPRM1 OPRL1
4 axon GO:0030424 9.5 TAC1 SCN9A SCN8A SCN3A SCN11A P2RX3
5 integral component of presynaptic membrane GO:0099056 9.46 SCN10A P2RX3 OPRM1 OPRD1
6 spine apparatus GO:0097444 9.32 OPRM1 OPRD1
7 voltage-gated sodium channel complex GO:0001518 9.02 SCN9A SCN8A SCN3A SCN11A SCN10A

Biological processes related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.19 TAC1 OPRM1 OPRL1 OPRK1 OPRD1 NPS
2 transmembrane transport GO:0055085 10.1 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN11A
3 ion transport GO:0006811 10.1 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN11A
4 ion transmembrane transport GO:0034220 9.95 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN10A
5 regulation of ion transmembrane transport GO:0034765 9.92 SCN9A SCN8A SCN3A SCN11A SCN10A
6 sodium ion transport GO:0006814 9.91 SCN9A SCN8A SCN3A SCN11A SCN10A
7 calcium ion transmembrane transport GO:0070588 9.85 TRPV1 TRPA1 OPRM1
8 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.85 OPRM1 OPRL1 OPRK1 OPRD1
9 sodium ion transmembrane transport GO:0035725 9.85 SCN9A SCN8A SCN3A SCN11A SCN10A
10 excitatory postsynaptic potential GO:0060079 9.82 TRPV1 P2RX3 OPRM1
11 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.81 OPRM1 OPRK1 OPRD1
12 response to heat GO:0009408 9.79 TRPV1 P2RX3 CALCA
13 cellular response to nerve growth factor stimulus GO:1990090 9.78 TRPV1 TAC1 CALCA
14 regulation of sensory perception of pain GO:0051930 9.78 SCN11A OPRM1 OPRL1 OPRD1
15 eating behavior GO:0042755 9.74 OPRM1 OPRL1 OPRD1
16 response to pain GO:0048265 9.73 TRPV1 TRPA1 TAC1 CALCA
17 behavioral response to pain GO:0048266 9.71 TRPV1 SCN9A P2RX3
18 neuropeptide signaling pathway GO:0007218 9.7 TAC1 OPRM1 OPRL1 OPRK1 OPRD1 NPS
19 cellular response to ATP GO:0071318 9.67 TRPV1 P2RX3
20 estrous cycle GO:0044849 9.67 OPRM1 OPRL1
21 opioid receptor signaling pathway GO:0038003 9.67 OPRM1 OPRL1 OPRK1 OPRD1
22 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.66 TRPV1 CALCA
23 positive regulation of synaptic transmission, GABAergic GO:0032230 9.66 TAC1 NPS
24 negative regulation of heart rate GO:0010459 9.65 TRPV1 TAC1
25 behavior GO:0007610 9.65 OPRL1 OPRK1
26 membrane depolarization during action potential GO:0086010 9.65 SCN9A SCN8A SCN3A SCN11A SCN10A
27 positive regulation of sensory perception of pain GO:1904058 9.63 P2RX3 OPRL1
28 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.63 OPRM1 OPRL1
29 urinary bladder smooth muscle contraction GO:0014832 9.62 TRPV1 P2RX3
30 positive regulation of action potential GO:0045760 9.62 TAC1 NPS
31 sensory perception GO:0007600 9.62 SCN10A OPRM1 OPRL1 OPRK1
32 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.6 TRPV1 TRPA1
33 thermoception GO:0050955 9.59 TRPV1 TRPA1
34 positive regulation of gastric acid secretion GO:0060454 9.58 TRPV1 OPRL1
35 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.58 OPRM1 OPRK1
36 neuronal action potential GO:0019228 9.43 SCN9A SCN8A SCN3A SCN11A SCN10A P2RX3
37 sensory perception of pain GO:0019233 9.23 TRPV1 TRPA1 TAC1 SCN9A SCN10A OPRM1

Molecular functions related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.77 SCN9A SCN8A SCN3A SCN11A SCN10A
2 peptide binding GO:0042277 9.71 OPRM1 OPRL1 OPRK1 OPRD1
3 neuropeptide binding GO:0042923 9.62 OPRM1 OPRL1 OPRK1 OPRD1
4 opioid receptor activity GO:0004985 9.56 OPRM1 OPRL1 OPRK1 OPRD1
5 sodium channel activity GO:0005272 9.55 SCN9A SCN8A SCN3A SCN11A SCN10A
6 ion channel activity GO:0005216 9.5 TRPV1 SCN9A SCN8A SCN3A SCN11A SCN10A
7 calcium-release channel activity GO:0015278 9.43 TRPV1 TRPA1
8 voltage-gated sodium channel activity GO:0005248 9.02 SCN9A SCN8A SCN3A SCN11A SCN10A

Sources for Trigeminal Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....