MCID: TRG003
MIFTS: 37

Trigeminal Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Trigeminal Nerve Disease

MalaCards integrated aliases for Trigeminal Nerve Disease:

Name: Trigeminal Nerve Disease 12 15 17
Trigeminal Nerve Diseases 71

Classifications:



External Ids:

Disease Ontology 12 DOID:561
ICD9CM 34 350.8
ICD10 32 G50 G50.8 G50.9
UMLS 71 C0029834 C0152177

Summaries for Trigeminal Nerve Disease

MalaCards based summary : Trigeminal Nerve Disease, also known as trigeminal nerve diseases, is related to sensory peripheral neuropathy and trigeminal neuralgia, and has symptoms including neurologic symptoms and atypical facial pain. An important gene associated with Trigeminal Nerve Disease is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and G-Beta Gamma Signaling. The drugs Acetylcholine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include pons and cortex, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in... more...

Related Diseases for Trigeminal Nerve Disease

Diseases related to Trigeminal Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 sensory peripheral neuropathy 29.9 TRPV1 SCN9A SCN11A NGF BDNF
2 trigeminal neuralgia 26.9 TRPV1 TRPM8 TRPA1 TAC1 SCN9A SCN8A
3 carbamazepine allergy 10.4 TAC1 CALCA
4 taylor's syndrome 10.4 TAC1 CALCA
5 genetic epilepsy with febrile seizures plus 10.3 SCN9A SCN1A
6 prurigo nodularis 10.3 TAC1 NGF
7 lesion of sciatic nerve 10.3 TRPV1 NGF
8 punctate epithelial keratoconjunctivitis 10.3 TAC1 NGF
9 indifference to pain, congenital, autosomal recessive 10.3 SCN9A SCN11A SCN10A
10 myoclonic epilepsy of infancy 10.3 SCN8A SCN1A
11 cough variant asthma 10.3 TRPV1 NGF
12 sodium channelopathy-related small fiber neuropathy 10.3 SCN9A SCN11A SCN10A
13 erythermalgia, primary 10.3 SCN9A SCN11A SCN10A
14 facial dermatosis 10.3 TRPV1 TRPA1 TAC1
15 pseudopterygium 10.3 TRPV1 TRPA1 TAC1
16 spondyloepiphyseal dysplasia, maroteaux type 10.3 TRPA1 SCN9A
17 developmental and epileptic encephalopathy 13 10.3 SCN8A SCN1A
18 mononeuropathy 10.3 TRPV1 TAC1 NGF
19 low compliance bladder 10.3 P2RX3 NGF
20 facial neuralgia 10.3 TAC1 LIPN
21 febrile seizures 10.3 SCN9A SCN8A SCN1A
22 adrenal gland pheochromocytoma 10.3 NGF BDNF
23 migraine, familial hemiplegic, 3 10.3 SCN9A SCN3A SCN1A
24 partial motor epilepsy 10.3 SCN8A SCN1A
25 generalized epilepsy with febrile seizures plus, type 2 10.3 SCN9A SCN1A SCN11A
26 photokeratitis 10.3 TRPV1 TRPM8 TRPA1
27 interval angle-closure glaucoma 10.2 TAC1 KNG1
28 dentin sensitivity 10.2 TRPV1 TRPM8 TRPA1
29 generalized epilepsy with febrile seizures plus, type 7 10.2 SCN9A SCN8A SCN1A
30 mutilating palmoplantar keratoderma with periorificial keratotic plaques 10.2 TRPV1 TRPM8 TRPA1
31 low-grade astrocytoma 10.2 SCN8A SCN3A SCN1A
32 urethral syndrome 10.2 TAC1 P2RX3 NGF
33 episodic pain syndrome, familial, 2 10.2 SCN9A SCN3A SCN11A SCN10A
34 autonomic neuropathy 10.2 SCN9A SCN11A NGF
35 episodic pain syndrome, familial, 3 10.2 SCN9A SCN3A SCN11A SCN10A
36 familial febrile seizures 10.2 SCN9A SCN3A SCN1A
37 neuropathy, hereditary sensory and autonomic, type vii 10.2 SCN4A SCN3A SCN11A
38 headache 10.2 TAC1 SCN1A CALCA
39 hemiplegia 10.2 TAC1 SCN1A CALCA
40 alternating hemiplegia of childhood 10.2 TAC1 SCN1A CALCA
41 neuropathy, hereditary sensory and autonomic, type v 10.2 SCN11A NGF BDNF
42 plantar fasciitis 10.2 TAC1 LIPN CALCA
43 neurogenic arthropathy 10.2 TAC1 SCN9A NGF CALCA
44 intracranial vasospasm 10.2 TAC1 KNG1
45 meningoencephalitis 10.2 TAC1 NGF BDNF
46 acute apical periodontitis 10.2 TAC1 KNG1
47 hereditary sensory neuropathy 10.2 SCN9A NGF BDNF
48 akinetopsia 10.2 TAC1 KNG1
49 neurotrophic keratopathy 10.2 TACR1 TAC1
50 perianal hematoma 10.2 TAC1 KNG1 CALCA

Graphical network of the top 20 diseases related to Trigeminal Nerve Disease:



Diseases related to Trigeminal Nerve Disease

Symptoms & Phenotypes for Trigeminal Nerve Disease

UMLS symptoms related to Trigeminal Nerve Disease:


neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Trigeminal Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.39 BDNF FOS KNG1 NGF OPRM1 P2RX3
2 homeostasis/metabolism MP:0005376 10.22 BDNF FOS KNG1 LIPN NGF OPRM1
3 integument MP:0010771 10.18 BDNF FOS NGF OPRM1 P2RX3 SCN10A
4 nervous system MP:0003631 10.17 BDNF FOS NGF OPRM1 P2RX3 SCN10A
5 normal MP:0002873 9.81 BDNF FOS NGF OPRM1 SCN1A SCN3A
6 no phenotypic analysis MP:0003012 9.8 BDNF NGF OPRM1 SCN10A SCN3A TRPA1
7 respiratory system MP:0005388 9.56 BDNF P2RX3 SCN10A SCN1A SCN4A SCN8A
8 taste/olfaction MP:0005394 8.92 BDNF SCN9A TRPA1 TRPV1

Drugs & Therapeutics for Trigeminal Nerve Disease

Drugs for Trigeminal Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
2 Pharmaceutical Solutions Phase 3
3 abobotulinumtoxinA Phase 3
4 Botulinum Toxins, Type A Phase 3
5 Neurotransmitter Agents Phase 3
6 Botulinum Toxins Phase 3
7 Cholinergic Agents Phase 3
8
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
9
Guanfacine Approved, Investigational Phase 2 29110-47-2 3519
10 Adrenergic alpha-Agonists Phase 2
11 Sodium Channel Blockers Phase 2
12 Anesthetics Phase 2
13 Antihypertensive Agents Phase 2
14 Diuretics, Potassium Sparing Phase 2
15 Adrenergic Agents Phase 2
16 Anesthetics, Local Phase 2
17 Adrenergic Agonists Phase 2
18 Anti-Arrhythmia Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Botulinum Toxin (BTX) for the Treatment of Peripheral Painful Traumatic Trigeminal Neuropathy (PPTTN) Recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
2 A Randomized, Double-Blind, 2-Way Crossover Trial to Assess the Efficacy of Guanfacine and Lidocaine Combination Versus Lidocaine Alone in Trigeminal Nerve Block for Pain Management in Painful Trigeminal Neuropathy Patients Recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
3 Bilateral vs. Unilateral Transcranial Magnetic Stimulation of the Primary Motor Cortex to Treat Chronic Orofacial Pain: a Pilot Study With a Randomized Controlled Design Unknown status NCT03710967
4 Post-traumatic Neuropathy of the Trigeminal Nerve Completed NCT04612855

Search NIH Clinical Center for Trigeminal Nerve Disease

Genetic Tests for Trigeminal Nerve Disease

Anatomical Context for Trigeminal Nerve Disease

MalaCards organs/tissues related to Trigeminal Nerve Disease:

40
Pons, Cortex

Publications for Trigeminal Nerve Disease

Articles related to Trigeminal Nerve Disease:

# Title Authors PMID Year
1
Magnetic resonance imaging contrast enhancement of the trigeminal nerve in dogs without evidence of trigeminal neuropathy. 61
19507390 2009
2
The effect of unilateral corneal anesthesia on the Schirmer test. 61
2501743 1989
3
Evoked taste thresholds in a normal population and the application of electrogustometry to trigeminal nerve disease. 61
3819752 1987

Variations for Trigeminal Nerve Disease

Expression for Trigeminal Nerve Disease

Search GEO for disease gene expression data for Trigeminal Nerve Disease.

Pathways for Trigeminal Nerve Disease

Pathways related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
2
Show member pathways
12.89 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
3
Show member pathways
12.68 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
4
Show member pathways
12.5 TRPV1 TRPM8 TRPA1 NGF KNG1 FOS
5 12.44 SCN9A SCN8A SCN4A SCN1A SCN11A SCN10A
6
Show member pathways
12.29 TACR1 TAC1 SCN9A SCN8A SCN4A SCN3A
7 12.01 TACR1 TAC1 NGF BDNF
8
Show member pathways
11.96 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
9
Show member pathways
11.57 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
10 11.03 TRPV1 TRPM8 TRPA1
11 10.64 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
12 10.36 TACR1 TAC1

GO Terms for Trigeminal Nerve Disease

Cellular components related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.25 TRPV1 TRPM8 TRPA1 TACR1 SCN9A SCN8A
2 plasma membrane GO:0005886 10.03 TRPV1 TRPM8 TRPA1 TACR1 TAC1 SCN9A
3 integral component of plasma membrane GO:0005887 9.92 TRPV1 TRPM8 TRPA1 TACR1 SCN9A SCN4A
4 neuronal cell body GO:0043025 9.8 TRPV1 TAC1 SCN1A P2RX3 CALCA
5 neuron projection GO:0043005 9.73 TRPV1 SCN9A P2RX3 OPRM1 FOS CALCA
6 integral component of presynaptic membrane GO:0099056 9.54 SCN10A P2RX3 OPRM1
7 voltage-gated sodium channel complex GO:0001518 9.5 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
8 axon initial segment GO:0043194 9.48 SCN8A SCN1A
9 node of Ranvier GO:0033268 9.46 SCN8A SCN1A
10 axon GO:0030424 9.44 TAC1 SCN9A SCN8A SCN4A SCN3A SCN1A

Biological processes related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10.18 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN4A
2 inflammatory response GO:0006954 10.08 TRPV1 TACR1 TAC1 SCN9A KNG1 FOS
3 regulation of ion transmembrane transport GO:0034765 10.04 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
4 positive regulation of cytosolic calcium ion concentration GO:0007204 10 TRPV1 TACR1 TAC1 OPRM1 KNG1 CALCA
5 sodium ion transport GO:0006814 10 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
6 ion transport GO:0006811 10 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN4A
7 ion transmembrane transport GO:0034220 9.97 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN3A
8 sensory perception of pain GO:0019233 9.91 TRPV1 TRPA1 TAC1 SCN9A SCN10A OPRM1
9 sodium ion transmembrane transport GO:0035725 9.91 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
10 calcium ion transmembrane transport GO:0070588 9.88 TRPV1 TRPM8 TRPA1 OPRM1
11 response to cold GO:0009409 9.85 TRPM8 TRPA1 P2RX3 FOS
12 neuropeptide signaling pathway GO:0007218 9.84 TAC1 OPRM1 CALCA
13 modulation of chemical synaptic transmission GO:0050804 9.81 P2RX3 NGF BDNF
14 response to pain GO:0048265 9.8 TRPV1 TRPA1 TACR1 TAC1 CALCA
15 excitatory postsynaptic potential GO:0060079 9.79 TRPV1 P2RX3 OPRM1
16 response to heat GO:0009408 9.78 TRPV1 P2RX3 CALCA
17 cellular response to nerve growth factor stimulus GO:1990090 9.77 TRPV1 TAC1 CALCA
18 peripheral nervous system development GO:0007422 9.74 SCN8A NGF BDNF
19 behavioral response to pain GO:0048266 9.73 TRPV1 SCN9A P2RX3
20 cation transmembrane transport GO:0098655 9.7 TRPM8 SCN9A SCN8A SCN3A SCN1A SCN10A
21 thermoception GO:0050955 9.69 TRPV1 TRPM8 TRPA1
22 cellular response to ATP GO:0071318 9.67 TRPV1 P2RX3
23 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.67 TRPV1 CALCA
24 nerve development GO:0021675 9.66 NGF BDNF
25 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.65 TRPA1 SCN1A
26 sensory perception GO:0007600 9.65 SCN10A OPRM1
27 nerve growth factor signaling pathway GO:0038180 9.65 NGF BDNF
28 negative regulation of heart rate GO:0010459 9.64 TRPV1 TAC1
29 response to temperature stimulus GO:0009266 9.63 TRPM8 P2RX3
30 positive regulation of collateral sprouting GO:0048672 9.63 NGF BDNF
31 tachykinin receptor signaling pathway GO:0007217 9.62 TACR1 TAC1
32 urinary bladder smooth muscle contraction GO:0014832 9.61 TRPV1 P2RX3
33 detection of abiotic stimulus GO:0009582 9.6 TACR1 TAC1
34 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.58 TRPV1 TRPA1
35 membrane depolarization during action potential GO:0086010 9.5 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
36 neuronal action potential GO:0019228 9.23 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A

Molecular functions related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.87 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
2 sodium channel activity GO:0005272 9.8 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
3 voltage-gated sodium channel activity GO:0005248 9.7 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
4 calcium channel activity GO:0005262 9.61 TRPV1 TRPM8 TRPA1
5 cation channel activity GO:0005261 9.61 TRPV1 TRPM8 SCN9A SCN8A SCN4A SCN3A
6 calcium-release channel activity GO:0015278 9.4 TRPV1 TRPA1
7 nerve growth factor receptor binding GO:0005163 9.37 NGF BDNF
8 ion channel activity GO:0005216 9.36 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN4A

Sources for Trigeminal Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....