MCID: TRG003
MIFTS: 24

Trigeminal Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Trigeminal Nerve Disease

MalaCards integrated aliases for Trigeminal Nerve Disease:

Name: Trigeminal Nerve Disease 12 15
Trigeminal Nerve Diseases 73

Classifications:



External Ids:

Disease Ontology 12 DOID:561
ICD9CM 35 350.8
ICD10 33 G50 G50.8

Summaries for Trigeminal Nerve Disease

MalaCards based summary : Trigeminal Nerve Disease, also known as trigeminal nerve diseases, is related to paroxysmal extreme pain disorder and facial nerve disease, and has symptoms including neurologic symptoms and atypical facial pain. An important gene associated with Trigeminal Nerve Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). The drugs Carbamazepine and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include pons, and related phenotypes are behavior/neurological and taste/olfaction

Wikipedia : 76 The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in... more...

Related Diseases for Trigeminal Nerve Disease

Graphical network of the top 20 diseases related to Trigeminal Nerve Disease:



Diseases related to Trigeminal Nerve Disease

Symptoms & Phenotypes for Trigeminal Nerve Disease

UMLS symptoms related to Trigeminal Nerve Disease:


neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Trigeminal Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.5 CRLF1 JMJD6 MBD1 PGRMC1 SCN9A TAC1
2 taste/olfaction MP:0005394 8.8 PGRMC1 SCN9A TRPV1

Drugs & Therapeutics for Trigeminal Nerve Disease

Drugs for Trigeminal Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 298-46-4 2554
2
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
3
Ondansetron Approved Phase 4 99614-02-5 4595
4
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
5
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
6
Oxcarbazepine Approved Phase 4 28721-07-5 34312
7 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
8 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
9 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
10 Excitatory Amino Acid Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
11 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Tranquilizing Agents Phase 4,Phase 2,Phase 3,Not Applicable
13 Psychotropic Drugs Phase 4,Phase 2,Phase 3,Not Applicable
14 Analgesics, Opioid Phase 4
15 Anesthetics Phase 4,Not Applicable
16 Excitatory Amino Acids Phase 4,Phase 2,Phase 3,Not Applicable
17 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Not Applicable
18 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 3,Not Applicable
19 Sodium Channel Blockers Phase 4,Phase 2,Phase 3,Not Applicable
20 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Not Applicable
21 Anticonvulsants Phase 4,Phase 2,Phase 3,Not Applicable
22 Antimanic Agents Phase 4,Phase 2,Phase 3,Not Applicable
23 Dermatologic Agents Phase 4,Not Applicable
24 Anti-Anxiety Agents Phase 4
25 Anesthetics, Intravenous Phase 4
26 Anesthetics, Dissociative Phase 4
27 Antiemetics Phase 4
28 Narcotics Phase 4
29 Serotonin Antagonists Phase 4
30 Anesthetics, General Phase 4
31 Antipruritics Phase 4
32 Antipsychotic Agents Phase 4
33 Gastrointestinal Agents Phase 4
34 Serotonin Agents Phase 4
35 Autonomic Agents Phase 4
36 Adjuvants, Anesthesia Phase 4
37
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
38
Lamotrigine Approved, Investigational Phase 2, Phase 3,Not Applicable 84057-84-1 3878
39
Acetylcholine Approved Phase 3,Phase 1,Phase 2 51-84-3 187
40
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
41 Calcium, Dietary Phase 2, Phase 3,Not Applicable
42 calcium channel blockers Phase 2, Phase 3,Not Applicable
43 onabotulinumtoxinA Phase 3,Phase 1,Phase 2
44 Acetylcholine Release Inhibitors Phase 3,Phase 1,Phase 2
45 abobotulinumtoxinA Phase 3,Phase 1,Phase 2
46 Cholinergic Agents Phase 3,Phase 1,Phase 2
47 Neuromuscular Agents Phase 3,Phase 1,Phase 2
48 Botulinum Toxins, Type A Phase 3,Phase 1,Phase 2
49 Botulinum Toxins Phase 3,Phase 1,Phase 2
50 Protective Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
2 Postoperative Analgesia in Patients With Microvascular Decompression Active, not recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
3 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
4 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
5 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
6 Botulinum Toxin Injections for Oral Neuropathic Pain Not yet recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
7 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
8 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
9 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
10 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
11 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
12 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
13 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
14 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
15 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
16 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
17 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Recruiting NCT02624661 Phase 1, Phase 2 Glycerol
18 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
19 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
20 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
21 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
22 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
23 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630 Not Applicable
24 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
25 Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury Unknown status NCT01586598 Not Applicable
26 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
27 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
28 Classical Trigeminal Neuralgia and Sodium Channel Mutations Completed NCT03656497
29 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia Completed NCT03549013
30 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406 Not Applicable
31 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
32 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Not Applicable Lidocaine
33 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Completed NCT01761604 Not Applicable
34 Hippocampal Radiation Exposure and Memory Completed NCT00603694
35 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807 Not Applicable
36 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 Not Applicable lamotrigine;Placebo
37 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 Not Applicable L-baclofen
38 Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital Recruiting NCT03669744
39 Neurosurgical Transitional Care Programme Recruiting NCT03593330 Not Applicable
40 High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia Recruiting NCT03131466 Not Applicable Nerve block
41 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323
42 An Follow-up Study of Occlusal Adjustment for Orofacial Pain Recruiting NCT02856906 Not Applicable
43 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810 Not Applicable
44 Bilateral TMS vs. Unilateral TMS Active, not recruiting NCT03710967 Not Applicable
45 Transcranial Magnetic Stimulation for Facial Pain Active, not recruiting NCT02633306 Not Applicable
46 Comparison Between Radiofrequency and Balloon Compression in the Treatment of Idiopathic Trigeminal Neuralgia Active, not recruiting NCT02427074 Not Applicable
47 RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT Enrolling by invitation NCT01885299
48 Neurophysiologic Signatures of Trigeminal Neuralgia Pain Not yet recruiting NCT03778177 Not Applicable
49 Phenytoin as Treatment for Acute Exacerbations of Trigeminal Neuralgia - a Prospective Systematic Study of 20 Patients Not yet recruiting NCT03712254 Fosphenytoin
50 Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia Not yet recruiting NCT03580317 Not Applicable

Search NIH Clinical Center for Trigeminal Nerve Disease

Genetic Tests for Trigeminal Nerve Disease

Anatomical Context for Trigeminal Nerve Disease

MalaCards organs/tissues related to Trigeminal Nerve Disease:

41
Pons

Publications for Trigeminal Nerve Disease

Articles related to Trigeminal Nerve Disease:

# Title Authors Year
1
Evoked taste thresholds in a normal population and the application of electrogustometry to trigeminal nerve disease. ( 3819752 )
1987

Variations for Trigeminal Nerve Disease

Expression for Trigeminal Nerve Disease

Search GEO for disease gene expression data for Trigeminal Nerve Disease.

Pathways for Trigeminal Nerve Disease

GO Terms for Trigeminal Nerve Disease

Biological processes related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to nerve growth factor stimulus GO:1990090 9.26 TAC1 TRPV1
2 response to pain GO:0048265 9.16 TAC1 TRPV1
3 behavioral response to pain GO:0048266 8.96 SCN9A TRPV1
4 sensory perception of pain GO:0019233 8.8 SCN9A TAC1 TRPV1

Sources for Trigeminal Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....