MCID: TRG003
MIFTS: 36

Trigeminal Nerve Disease

Categories: Neuronal diseases

Aliases & Classifications for Trigeminal Nerve Disease

MalaCards integrated aliases for Trigeminal Nerve Disease:

Name: Trigeminal Nerve Disease 12 15 17
Trigeminal Nerve Diseases 71

Classifications:



External Ids:

Disease Ontology 12 DOID:561
ICD9CM 34 350.8
ICD10 32 G50 G50.8 G50.9
UMLS 71 C0029834 C0152177

Summaries for Trigeminal Nerve Disease

MalaCards based summary : Trigeminal Nerve Disease, also known as trigeminal nerve diseases, is related to sensory peripheral neuropathy and trigeminal neuralgia, and has symptoms including neurologic symptoms and atypical facial pain. An important gene associated with Trigeminal Nerve Disease is MBD1 (Methyl-CpG Binding Domain Protein 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Cardiac conduction. The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include pons, cortex and testes, and related phenotypes are behavior/neurological and integument

Wikipedia : 74 The trigeminal nerve (the fifth cranial nerve, or simply CN V) is a nerve responsible for sensation in... more...

Related Diseases for Trigeminal Nerve Disease

Diseases related to Trigeminal Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 sensory peripheral neuropathy 29.4 TRPV1 TRPA1 TAC1 NGF CALCA
2 trigeminal neuralgia 24.8 TRPV1 TRPA1 TAC1 SCN9A SCN8A SCN3A
3 facial neuralgia 10.4 TAC1 MBD1 CRLF1
4 glossopharyngeal nerve disease 10.4 KANTR CRLF1
5 glossopharyngeal neuralgia 10.4 TAC1 KANTR CRLF1
6 cerebellopontine angle tumor 10.4 KANTR CRLF1
7 episodic pain syndrome, familial, 2 10.4 SCN9A SCN3A SCN10A
8 sodium channelopathy-related small fiber neuropathy 10.3 SCN9A SCN11A SCN10A
9 arachnoiditis 10.3 TAC1 CRLF1
10 indifference to pain, congenital, autosomal recessive 10.3 SCN9A SCN11A SCN10A
11 carbamazepine allergy 10.3 TAC1 NPS CALCA
12 erythermalgia, primary 10.3 SCN9A SCN11A SCN10A
13 intracranial hypotension 10.3 MBD1 CRLF1
14 complex regional pain syndrome 10.3 TAC1 SCN9A CALCA
15 perianal hematoma 10.3 TAC1 NPS CALCA
16 neuropathy, hereditary sensory and autonomic, type vii 10.3 SCN3A SCN11A
17 neurodermatitis 10.3 TAC1 NPS KANTR
18 dental pulp disease 10.3 TRPV1 TAC1 NPS
19 hyperhidrosis, gustatory 10.3 TRPV1 TRPA1 TAC1
20 epicondylitis 10.3 TAC1 NPS CALCA
21 progressive familial heart block, type ia 10.3 SCN9A SCN8A SCN3A
22 reflex sympathetic dystrophy 10.3 TAC1 NPS CALCA
23 photokeratitis 10.3 TRPV1 TRPA1
24 aids phobia 10.3 TAC1 SCN11A NPS
25 neonatal period electroclinical syndrome 10.3 SCN9A SCN8A SCN3A
26 electroclinical syndrome 10.2 SCN9A SCN8A SCN3A
27 prurigo nodularis 10.2 TAC1 NGF
28 benign familial infantile epilepsy 10.2 SCN9A SCN8A SCN3A
29 episodic pain syndrome, familial, 3 10.2 SCN9A SCN3A SCN11A SCN10A
30 mononeuritis of lower limb 10.2 TRPV1 NGF
31 dentin sensitivity 10.2 TRPV1 TRPA1
32 neurogenic arthropathy 10.2 NGF CALCA
33 causalgia 10.2 TRPV1 TAC1 NPS CALCA
34 myofascial pain syndrome 10.2 TRPV1 TAC1 NPS CALCA
35 vasomotor rhinitis 10.2 TRPV1 TAC1 NPS CALCA
36 cough variant asthma 10.2 TRPV1 TAC1 NGF
37 lesion of sciatic nerve 10.2 TRPV1 NGF
38 punctate epithelial keratoconjunctivitis 10.1 TAC1 NGF
39 lennox-gastaut syndrome 10.1 TRPV1 SCN9A SCN8A SCN3A
40 mononeuropathy 10.1 TRPV1 TAC1 NGF
41 nerve compression syndrome 10.1 TRPV1 TAC1 NGF
42 paralytic ileus 10.1 TAC1 OPRM1
43 migraine, familial hemiplegic, 3 10.1 SCN9A SCN3A
44 low-grade astrocytoma 10.1 SCN8A SCN3A
45 familial hemiplegic migraine 10.1 P2RX3 OPRM1 CALCA
46 low compliance bladder 10.0 P2RX3 NPS NGF
47 autonomic neuropathy 10.0 SCN9A SCN11A NGF
48 urethral syndrome 10.0 TAC1 P2RX3 NGF
49 erythromelalgia 10.0 SCN9A SCN8A SCN3A SCN11A SCN10A
50 cystitis 10.0 TRPV1 TAC1 P2RX3 NGF

Graphical network of the top 20 diseases related to Trigeminal Nerve Disease:



Diseases related to Trigeminal Nerve Disease

Symptoms & Phenotypes for Trigeminal Nerve Disease

UMLS symptoms related to Trigeminal Nerve Disease:


neurologic symptoms, atypical facial pain

MGI Mouse Phenotypes related to Trigeminal Nerve Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.16 CRLF1 MBD1 NGF OPRD1 OPRK1 OPRL1
2 integument MP:0010771 9.93 NGF OPRD1 OPRK1 OPRL1 OPRM1 P2RX3
3 nervous system MP:0003631 9.8 CRLF1 MBD1 NGF OPRD1 OPRK1 OPRL1
4 no phenotypic analysis MP:0003012 9.17 NGF OPRD1 OPRM1 SCN10A SCN3A TRPA1

Drugs & Therapeutics for Trigeminal Nerve Disease

Drugs for Trigeminal Nerve Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
2 Neurotransmitter Agents Phase 3
3 abobotulinumtoxinA Phase 3
4 Cholinergic Agents Phase 3
5 Pharmaceutical Solutions Phase 3
6 Botulinum Toxins, Type A Phase 3
7 Botulinum Toxins Phase 3
8
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
9
Guanfacine Approved, Investigational Phase 2 29110-47-2 3519
10 Adrenergic alpha-Agonists Phase 2
11 Sodium Channel Blockers Phase 2
12 Anesthetics Phase 2
13 Antihypertensive Agents Phase 2
14 Adrenergic Agents Phase 2
15 Anti-Arrhythmia Agents Phase 2
16 Adrenergic Agonists Phase 2
17 Diuretics, Potassium Sparing Phase 2
18 Anesthetics, Local Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Botulinum Toxin (BTX) for the Treatment of Peripheral Painful Traumatic Trigeminal Neuropathy (PPTTN) Recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
2 A Randomized, Double-Blind, 2-Way Crossover Trial to Assess the Efficacy of Guanfacine and Lidocaine Combination Versus Lidocaine Alone in Trigeminal Nerve Block for Pain Management in Painful Trigeminal Neuropathy Patients Recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
3 Bilateral vs. Unilateral Transcranial Magnetic Stimulation of the Primary Motor Cortex to Treat Chronic Orofacial Pain: a Pilot Study With a Randomized Controlled Design Unknown status NCT03710967

Search NIH Clinical Center for Trigeminal Nerve Disease

Genetic Tests for Trigeminal Nerve Disease

Anatomical Context for Trigeminal Nerve Disease

MalaCards organs/tissues related to Trigeminal Nerve Disease:

40
Pons, Cortex, Testes

Publications for Trigeminal Nerve Disease

Articles related to Trigeminal Nerve Disease:

# Title Authors PMID Year
1
Magnetic resonance imaging contrast enhancement of the trigeminal nerve in dogs without evidence of trigeminal neuropathy. 61
19507390 2009
2
The effect of unilateral corneal anesthesia on the Schirmer test. 61
2501743 1989
3
Evoked taste thresholds in a normal population and the application of electrogustometry to trigeminal nerve disease. 61
3819752 1987

Variations for Trigeminal Nerve Disease

Expression for Trigeminal Nerve Disease

Search GEO for disease gene expression data for Trigeminal Nerve Disease.

Pathways for Trigeminal Nerve Disease

Pathways related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 TRPV1 TAC1 P2RX3 OPRM1 OPRL1 OPRK1
2
Show member pathways
12.53 SCN9A SCN8A SCN3A SCN11A SCN10A
3
Show member pathways
12.39 TAC1 SCN9A SCN8A SCN3A SCN11A SCN10A
4 12.23 SCN9A SCN8A SCN11A SCN10A OPRM1 NGF
5
Show member pathways
11.75 SCN9A SCN8A SCN3A SCN11A SCN10A
6
Show member pathways
11.7 SCN9A SCN3A P2RX3
7
Show member pathways
11.23 SCN9A SCN8A SCN3A SCN11A SCN10A
8 10.5 SCN9A SCN8A SCN3A SCN11A SCN10A

GO Terms for Trigeminal Nerve Disease

Cellular components related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.29 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN11A
2 plasma membrane GO:0005886 10.27 TRPV1 TRPA1 TAC1 SCN9A SCN8A SCN3A
3 integral component of plasma membrane GO:0005887 9.97 TRPV1 TRPA1 SCN9A P2RX3 OPRM1 OPRL1
4 cell GO:0005623 9.95 TRPV1 TRPA1 TAC1 P2RX3 OPRL1 OPRK1
5 neuronal cell body GO:0043025 9.83 TRPV1 TAC1 P2RX3 OPRK1 CALCA
6 neuron projection GO:0043005 9.76 TRPV1 SCN9A P2RX3 OPRM1 OPRL1 OPRK1
7 integral component of presynaptic membrane GO:0099056 9.65 SCN10A P2RX3 OPRM1 OPRK1 OPRD1
8 voltage-gated sodium channel complex GO:0001518 9.35 SCN9A SCN8A SCN3A SCN11A SCN10A
9 spine apparatus GO:0097444 9.32 OPRM1 OPRD1
10 axon GO:0030424 9.32 TAC1 SCN9A SCN8A SCN3A SCN11A SCN10A

Biological processes related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.21 TAC1 OPRM1 OPRL1 OPRK1 OPRD1 NPS
2 transmembrane transport GO:0055085 10.11 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN11A
3 ion transport GO:0006811 10.11 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN11A
4 ion transmembrane transport GO:0034220 10 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN10A
5 regulation of ion transmembrane transport GO:0034765 9.93 SCN9A SCN8A SCN3A SCN11A SCN10A
6 sodium ion transport GO:0006814 9.92 SCN9A SCN8A SCN3A SCN11A SCN10A
7 sodium ion transmembrane transport GO:0035725 9.89 SCN9A SCN8A SCN3A SCN11A SCN10A
8 calcium ion transmembrane transport GO:0070588 9.86 TRPV1 TRPA1 OPRM1
9 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0007193 9.86 OPRM1 OPRL1 OPRK1 OPRD1
10 excitatory postsynaptic potential GO:0060079 9.83 TRPV1 P2RX3 OPRM1
11 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.83 OPRM1 OPRK1 OPRD1
12 response to cocaine GO:0042220 9.81 OPRM1 OPRK1 MBD1
13 response to heat GO:0009408 9.8 TRPV1 P2RX3 CALCA
14 cellular response to nerve growth factor stimulus GO:1990090 9.8 TRPV1 TAC1 CALCA
15 neuropeptide signaling pathway GO:0007218 9.8 TAC1 OPRM1 OPRL1 OPRK1 OPRD1 NPS
16 response to morphine GO:0043278 9.78 TAC1 OPRM1 OPRK1
17 eating behavior GO:0042755 9.78 OPRM1 OPRL1 OPRK1 OPRD1
18 estrous cycle GO:0044849 9.75 OPRM1 OPRL1 OPRK1
19 response to pain GO:0048265 9.73 TRPV1 TRPA1 TAC1 CALCA
20 behavioral response to pain GO:0048266 9.72 TRPV1 SCN9A P2RX3
21 regulation of sensory perception of pain GO:0051930 9.72 SCN11A OPRM1 OPRL1 OPRK1 OPRD1
22 sensory perception GO:0007600 9.71 SCN10A OPRM1 OPRL1 OPRK1
23 cellular response to ATP GO:0071318 9.68 TRPV1 P2RX3
24 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.68 TRPV1 CALCA
25 behavior GO:0007610 9.67 OPRL1 OPRK1
26 positive regulation of synaptic transmission, GABAergic GO:0032230 9.67 TAC1 NPS
27 negative regulation of heart rate GO:0010459 9.67 TRPV1 TAC1
28 opioid receptor signaling pathway GO:0038003 9.67 OPRM1 OPRL1 OPRK1 OPRD1
29 positive regulation of sensory perception of pain GO:1904058 9.65 P2RX3 OPRL1
30 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.65 OPRM1 OPRL1
31 urinary bladder smooth muscle contraction GO:0014832 9.64 TRPV1 P2RX3
32 positive regulation of action potential GO:0045760 9.64 TAC1 NPS
33 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.62 TRPV1 TRPA1
34 thermoception GO:0050955 9.61 TRPV1 TRPA1
35 conditioned place preference GO:1990708 9.6 OPRL1 OPRK1
36 positive regulation of gastric acid secretion GO:0060454 9.59 TRPV1 OPRL1
37 adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 9.58 OPRM1 OPRK1
38 membrane depolarization during action potential GO:0086010 9.55 SCN9A SCN8A SCN3A SCN11A SCN10A
39 neuronal action potential GO:0019228 9.43 SCN9A SCN8A SCN3A SCN11A SCN10A P2RX3
40 sensory perception of pain GO:0019233 9.23 TRPV1 TRPA1 TAC1 SCN9A SCN10A OPRM1

Molecular functions related to Trigeminal Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.8 SCN9A SCN8A SCN3A SCN11A SCN10A
2 peptide binding GO:0042277 9.73 OPRM1 OPRL1 OPRK1 OPRD1
3 neuropeptide binding GO:0042923 9.67 OPRM1 OPRL1 OPRK1 OPRD1
4 sodium channel activity GO:0005272 9.65 SCN9A SCN8A SCN3A SCN11A SCN10A
5 opioid receptor activity GO:0004985 9.62 OPRM1 OPRL1 OPRK1 OPRD1
6 voltage-gated sodium channel activity GO:0005248 9.55 SCN9A SCN8A SCN3A SCN11A SCN10A
7 calcium-release channel activity GO:0015278 9.48 TRPV1 TRPA1
8 receptor serine/threonine kinase binding GO:0033612 9.46 OPRK1 OPRD1
9 cation channel activity GO:0005261 9.43 TRPV1 SCN9A SCN8A SCN3A SCN11A SCN10A
10 ion channel activity GO:0005216 9.23 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN11A

Sources for Trigeminal Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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