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MCID: TRG002
MIFTS: 61

Trigeminal Neuralgia

Categories: Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Trigeminal Neuralgia

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MalaCards integrated aliases for Trigeminal Neuralgia:

Name: Trigeminal Neuralgia 57 12 73 20 53 58 29 54 42 44 15 17 70 32
Tic Douloureux 57 20 53
Trifacial Neuralgia 12
Trifocal Neuralgia 12

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant form


HPO:

31
trigeminal neuralgia:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12098
OMIM® 57 190400
ICD9CM 34 350.1
MeSH 44 D014277
SNOMED-CT 67 155066002
ICD10 32 G50.0
MESH via Orphanet 45 D014277
ICD10 via Orphanet 33 G50.0
UMLS via Orphanet 71 C0040997
Orphanet 58 ORPHA221091
MedGen 41 C0040997
UMLS 70 C0040997
Sources

Summaries for Trigeminal Neuralgia

About this section
NINDS : 53 Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary : Trigeminal Neuralgia, also known as tic douloureux, is related to headache and neuroma, and has symptoms including seizures, tremor and back pain. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and Cardiac conduction. The drugs Ropivacaine and Ondansetron have been mentioned in the context of this disorder. Affiliated tissues include trigeminal ganglion, brain and bone, and related phenotypes are trigeminal neuralgia and depressivity

GARD : 20 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.

MedlinePlus : 42 Trigeminal neuralgia (TN) is a type of chronic pain that affects your face. It causes extreme, sudden burning or shock-like pain. It usually affects one side of the face. Any vibration on your face, even from talking, can set it off. The condition may come and go, disappearing for days or even months. But the longer you have it, the less often it goes away. TN usually affects people over 50, especially women. The cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. Tumors and multiple sclerosis can also cause TN, but in some cases the cause is unknown. There is no specific test for TN. It can be hard to diagnose, since many other conditions can cause facial pain. Treatment options include medicines, surgery, and complementary techniques. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 73 Trigeminal neuralgia (TN or TGN) is a long-term pain disorder that affects the trigeminal nerve. It is a... more...

More information from OMIM: 190400
Sources

Related Diseases for Trigeminal Neuralgia

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Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 503)
# Related Disease Score Top Affiliating Genes
1 headache 32.0 TAC1 SLC6A4 SCN1A CALCA
2 neuroma 30.7 TRPV1 SCN10A NGF CALCA
3 meningoencephalitis 30.5 TAC1 NGF BDNF
4 tooth disease 30.3 SCN9A SCN11A NTRK1 NGF ESR1
5 plantar fasciitis 30.3 TAC1 CALCA
6 anxiety 30.3 TAC1 SLC6A4 NGF ESR1 BDNF
7 vasomotor rhinitis 30.2 TRPV1 TAC1 CALCA
8 dry eye syndrome 30.2 NGF ESR1 BDNF
9 algoneurodystrophy 30.1 TAC1 NGF CALCA
10 nerve compression syndrome 30.1 TRPV1 TAC1 NGF
11 neuropathy 30.0 TRPV1 SCN9A SCN11A SCN10A NTRK1 NGF
12 post-traumatic stress disorder 30.0 SLC6A4 ESR1 BDNF
13 major depressive disorder 30.0 TAC1 SLC6A4 NGF ESR1 BDNF
14 reflex sympathetic dystrophy 30.0 TRPV1 TAC1 P2RX3 CALCA
15 migraine without aura 30.0 TRPM8 SLC6A4 SCN1A
16 postpartum depression 29.9 SLC6A4 LOC110806262 ESR1 BDNF
17 sleep disorder 29.9 TAC1 SLC6A4 FOS BDNF
18 focal epilepsy 29.8 SCN8A SCN3A SCN1A
19 myofascial pain syndrome 29.8 TRPV1 TAC1 NGF CALCA BDNF
20 diabetic neuropathy 29.7 TRPV1 TRPM8 SCN9A NTRK1 NGF CALCA
21 patulous eustachian tube 29.7 FOS CALCA
22 status epilepticus 29.7 SCN1A FOS BDNF
23 constipation 29.7 TRPV1 TAC1 SLC6A4 CALCA BDNF
24 amnestic disorder 29.6 NGF FOS BDNF
25 burning mouth syndrome 29.6 TRPV1 TAC1 SLC6A4 SCN9A P2RX3 NGF
26 sensory peripheral neuropathy 29.5 TRPV1 SCN9A SCN11A NTRK1 NGF BDNF
27 causalgia 29.2 TRPV1 TAC1 SCN9A SCN11A SCN10A P2RX3
28 migraine with aura 29.0 TRPM8 TAC1 SLC6A4 SCN1A P2RX3 LOC110806262
29 erythromelalgia 28.8 TRPV1 TRPA1 SCN9A SCN8A SCN4A SCN3A
30 pain agnosia 28.7 TRPV1 TRPM8 TRPA1 TAC1 SCN9A SCN10A
31 peripheral nervous system disease 27.6 TRPV1 TRPM8 TRPA1 TAC1 SCN9A SCN8A
32 paine syndrome 27.4 TRPV1 TRPM8 TRPA1 TAC1 SLC6A4 SCN9A
33 migraine with or without aura 1 27.2 TRPV1 TRPM8 TRPA1 TAC1 SLC6A4 SCN9A
34 glossopharyngeal neuralgia 11.4
35 sunct headache 11.2
36 trigeminal trophic syndrome 11.2
37 hemifacial atrophy, progressive 11.2
38 epidermoid brain cyst 11.2
39 hemifacial spasm, familial 10.9
40 hemifacial spasm 10.9
41 multiple sclerosis 10.8
42 persistent idiopathic facial pain 10.7
43 arteriovenous malformation 10.7
44 chronic pain 10.7
45 meningioma, familial 10.7
46 intracranial meningioma 10.7
47 secretory meningioma 10.7
48 lymphoplasmacyte-rich meningioma 10.7
49 paresthesia 10.7
50 keratitis, hereditary 10.6

Comorbidity relations with Trigeminal Neuralgia via Phenotypic Disease Network (PDN):


Acute Cystitis Glossopharyngeal Neuralgia
Hypertension, Essential Hypothyroidism
Multiple Sclerosis

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to Trigeminal Neuralgia
Sources

Symptoms & Phenotypes for Trigeminal Neuralgia

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Human phenotypes related to Trigeminal Neuralgia:

58 31 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 trigeminal neuralgia 58 31 obligate (100%) Obligate (100%) HP:0100661
2 depressivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0000716
3 allodynia 58 31 hallmark (90%) Very frequent (99-80%) HP:0012533
4 cluster headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0012199
5 paresthesia 58 31 frequent (33%) Frequent (79-30%) HP:0003401
6 feeding difficulties 58 31 frequent (33%) Frequent (79-30%) HP:0011968
7 sensory impairment 58 31 frequent (33%) Frequent (79-30%) HP:0003474
8 poor speech 58 31 frequent (33%) Frequent (79-30%) HP:0002465
9 mandibular pain 58 31 frequent (33%) Frequent (79-30%) HP:0200025
10 episodic paroxysmal anxiety 58 31 frequent (33%) Frequent (79-30%) HP:0000740
11 difficulty in tongue movements 58 31 frequent (33%) Frequent (79-30%) HP:0000183
12 vascular tortuosity 58 31 frequent (33%) Frequent (79-30%) HP:0004948
13 neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0002664
14 ocular pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0200026
15 peripheral demyelination 58 31 occasional (7.5%) Occasional (29-5%) HP:0011096
16 cns demyelination 58 31 occasional (7.5%) Occasional (29-5%) HP:0007305
17 cranial nerve compression 58 31 occasional (7.5%) Occasional (29-5%) HP:0001293
18 abnormality of the nervous system 31 HP:0000707

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Neuro:
trigeminal neuralgia

Clinical features from OMIM®:

190400 (Updated 20-May-2021)

UMLS symptoms related to Trigeminal Neuralgia:


seizures; tremor; back pain; headache; syncope; pain; chronic pain; sciatica; vertigo/dizziness; sleeplessness; neuralgia; facial pain; atypical facial pain; orofacial pain

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.39 BDNF ESR1 FOS NGF NTRK1 P2RX3
2 growth/size/body region MP:0005378 10.22 BDNF ESR1 FOS NGF NTRK1 SCN11A
3 integument MP:0010771 10.21 BDNF ESR1 FOS NGF NTRK1 P2RX3
4 nervous system MP:0003631 10.2 BDNF ESR1 FOS NGF NTRK1 P2RX3
5 normal MP:0002873 9.9 BDNF ESR1 FOS NGF NTRK1 SCN1A
6 no phenotypic analysis MP:0003012 9.86 BDNF ESR1 NGF NTRK1 SCN10A SCN3A
7 respiratory system MP:0005388 9.56 BDNF ESR1 P2RX3 SCN10A SCN1A SCN4A
8 taste/olfaction MP:0005394 8.92 BDNF SCN9A TRPA1 TRPV1
Sources

Drugs & Therapeutics for Trigeminal Neuralgia

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Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
2
Ondansetron Approved Phase 4 99614-02-5 4595
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6 Narcotics Phase 4
7 Anesthetics, General Phase 4
8 Anesthetics, Intravenous Phase 4
9 Anti-Anxiety Agents Phase 4
10 Anesthetics, Dissociative Phase 4
11 Immunoglobulins Phase 4
12 Antibodies Phase 4
13 Antibodies, Blocking Phase 4
14 Anesthetics Phase 4
15 Anti-Arrhythmia Agents Phase 4
16 Anesthetics, Local Phase 4
17
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
18
Lamotrigine Approved, Investigational Phase 2, Phase 3 84057-84-1 3878
19
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
20 Antipsychotic Agents Phase 2, Phase 3
21 calcium channel blockers Phase 2, Phase 3
22 Calcium, Dietary Phase 2, Phase 3
23 Protective Agents Phase 3
24 Radiation-Protective Agents Phase 3
25
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
26
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
27
Dextromethorphan Approved Phase 2 125-71-3 5360696 5362449
28
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 2 14838-15-4 26934
29
Topiramate Approved Phase 2 97240-79-4 5284627
30
Salmon calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
31
Erenumab Approved, Investigational Phase 2 1582205-90-0
32
Guanfacine Approved, Investigational Phase 2 29110-47-2 3519
33
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
34
Glycerol Approved, Investigational Phase 1, Phase 2 56-81-5 753
35
Calcitonin gene-related peptide Investigational Phase 2 83652-28-2
36 Excitatory Amino Acid Antagonists Phase 2
37 Respiratory System Agents Phase 2
38 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
39 Antitussive Agents Phase 2
40 Katacalcin Phase 2
41 calcitonin Phase 2
42 Adrenergic alpha-Agonists Phase 2
43 Adrenergic Agonists Phase 2
44 Adrenergic Agents Phase 2
45 Antihypertensive Agents Phase 2
46 abobotulinumtoxinA Phase 2
47 Cholinergic Agents Phase 2
48 Botulinum Toxins, Type A Phase 2
49 Neurotransmitter Agents Phase 2
50 Botulinum Toxins Phase 2

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Novel Concepts for OnabotulinumtoxinA (Botox) Mechanisms of Action: Role in Altering the Molecular Environment in Which Pain Fibers Exist Unknown status NCT03381261 Phase 4 Botulinum toxin type A
2 Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
3 Examining the Efficacy of Low Intensity Low Frequency Surface Acoustic Wave Ultrasound(LILF/SAWU) in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
4 Anti-CGRP Neutralizing Antibody for Modulation of Neurogenic Inflammation in Trigeminal and Glossopharyngeal Pain Associated With Small Fiber Neuropathy/Fibromyalgia Recruiting NCT04158752 Phase 4 Galcanezumab
5 The PATCH Trial: Effectiveness and Safety of 5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia Not yet recruiting NCT04570293 Phase 4 5% lidocaine medicated plaster;vehicle plaster
6 Pilot Study of Oxtellar XR (Oxcarbazepine Extended Release) in Neurology Patients With Trigeminal Neuralgia Withdrawn NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
7 The Efficacy and Safety of Botulinum Toxin for the Treatment of Trigeminal Neuralgia: Comparison of Two Different Treatment Methods Unknown status NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
8 Lamotrigine in Trigeminal Neuralgia: Efficacy and Safety in Comparison With Carbamazepine Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
9 A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
10 A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
11 A Randomized, Placebo-controlled Trial of Amifostine for Prevention of Facial Numbness in Patients Receiving Stereotactic Radiosurgery for Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
12 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
13 Phase II Double Blind, Randomized, Placebo Controlled, Safety and Efficacy Study of ATNC05 in Patients With Atypical Facial Pain With an Open-Label Extension Phase for Nonresponders Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
14 A Prospective Study on Efficacy of Hyperbaric Oxygenation Treatment for Patients With Trigeminal Neuralgia: a Randomized, Double-Blind, Mock Hyperbaric Chamber -Controlled, Parallel-Group Trial Unknown status NCT00866424 Phase 1, Phase 2
15 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
16 A Placebo-Controlled, Single-Blind Study Evaluating the Safety and Efficacy of Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
17 A Phase IIa Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Safety and Efficacy of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
18 Clinical Trials in Orofacial Neuralgias Completed NCT00001725 Phase 2 Dextromethorphan
19 BHV3000-202: Phase 2: A Double-Blind, Placebo Controlled, Crossover Trial of BHV-3000 (Rimegepant) for Treatment Refractory Trigeminal Neuraligia Recruiting NCT03941834 Phase 2 Rimegepant;Placebo
20 A Placebo-Controlled, Double-Blind, Randomized, Proof-of-Concept Study to Evaluate the Efficacy and Tolerability of Erenumab in Patients With Trigeminal Neuralgia Recruiting NCT04054024 Phase 2 Erenumab;Placebos
21 A Randomized, Double-Blind, 2-Way Crossover Trial to Assess the Efficacy of Guanfacine and Lidocaine Combination Versus Lidocaine Alone in Trigeminal Nerve Block for Pain Management in Painful Trigeminal Neuropathy Patients Recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
22 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Terminated NCT02624661 Phase 1, Phase 2 Glycerol
23 A Randomized, Double-Blind, Placebo-Controlled, Add-on Therapy Study of Xeomin (Incobotulinumtoxina) Versus Placebo in the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
24 A Randomized, Double-blind, Placebo Controlled, Two Period Crossover Study to Investigate the Pharmacokinetics, Tolerability and Cognitive Effects of an Oral Dose Regimen of 150mg Tid CNV1014802 in Healthy Young Versus Elderly Male and Female Subjects Completed NCT02359344 Phase 1 CNV1014802;Placebo
25 A Phase 1, Open-label Study to Evaluate the Relative Bioavailability of Two Formulations of BIIB074 and to Assess the Effect of Food on BIIB074 Pharmacokinetics in Healthy Subjects Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
26 A Phase 1 Pharmacokinetics and Safety Study of BIIB074 in Healthy Japanese and Caucasian Subjects Completed NCT02831517 Phase 1 BIIB074;Placebo
27 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
28 Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache Withdrawn NCT04353505 Phase 1 Ketorolac;Dexamethasone
29 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630
30 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
31 Investigation of Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
32 Applied Research on Patients With Trigeminal Neuralgia by Multi-planar Reconstruction, Curved Planar Reconstruction and Magnetic Resonance Virtual Endoscopy Unknown status NCT02713646
33 Transitional Care Services: A Quality and Safety Process Improvement Programme in Neurosurgery Unknown status NCT03593330
34 Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital Completed NCT03669744
35 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 L-baclofen
36 Classical Trigeminal Neuralgia and Sodium Channel Mutations Completed NCT03656497
37 Comparison of Extended Duration Pulsed Radiofrequency Plus Low Temperature Thermal Radiofrequency With Thermal Radiofrequency Alone in Treatment of Recurrent Trigeminal Neuralgia Completed NCT03396406
38 The Long-Term Outcome of 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia: A Retrospective Study. Completed NCT03549013
39 Prognosis of Trigeminal Neuralgia When Enrolled in a Multidisciplinary Management Program - a Two-year Prospective Real-life Study Completed NCT03838393
40 A Double-Blind Placebo Controlled Add-on Study to Determine the Efficacy and Safety of Lamictal (Lamotrigine) in Patients With Trigeminal Neuralgia (Tic Doloureux) Completed NCT00203229 lamotrigine;Placebo
41 Symptomatic Trigeminal Neuralgia Attributed to Multiple Sclerosis - Clinical Characteristics, Neuroanatomical Abnormalities and Treatment Efficacy Completed NCT04371575 Carbamazepine
42 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Lidocaine
43 Pulsed Radiofrequency in Treatment of Classic Trigeminal Neuralgia (Prolonged Duration Versus Higher Voltage) Completed NCT04355221
44 Treatment of Primary Trigeminal Neuralgia: A Comparative Study of Microvascular Decompression and Stereotactic Gamma Knife Radiosurgery Completed NCT03991039
45 The Use of Tx360â„¢ Nasal Applicator for Sphenopalatine Ganglion Block in the Treatment of Trigeminal Neuralgia Completed NCT01761604
46 Hippocampal Radiation Exposure and Memory: A Pilot Study Completed NCT00603694
47 A Comparison of the EEGo and BIS Monitors to Assess Emergence From Neuroanesthesia Completed NCT00443807
48 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
49 A Personalised Radiosurgery Procedure for People With Trigeminal Neuralgia to Improve Pain, Quality of Life and Reduce Complications - a Confidence in Concept Pilot Study (PROMOTION) Recruiting NCT04117035
50 Phenytoin as Treatment for Acute Exacerbations of Trigeminal Neuralgia - a Prospective Systematic Study of 30 Patients Recruiting NCT03712254 Fosphenytoin

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Baclofen
Carbamazepine
tizanidine
tizanidine hydrochloride
Tocainide
Tocainide Monohydrochloride

Cochrane evidence based reviews: trigeminal neuralgia

Sources

Genetic Tests for Trigeminal Neuralgia

About this section

Genetic tests related to Trigeminal Neuralgia:

# Genetic test Affiliating Genes
1 Trigeminal Neuralgia 29
Sources

Anatomical Context for Trigeminal Neuralgia

About this section

MalaCards organs/tissues related to Trigeminal Neuralgia:

40
Trigeminal Ganglion, Brain, Bone, Tongue, Cortex, Pituitary, Eye
Sources

Publications for Trigeminal Neuralgia

About this section

Articles related to Trigeminal Neuralgia:

(show top 50) (show all 6480)
# Title Authors PMID Year
1
Familial trigeminal neuralgia: case report. 57 61
2716987 1989
2
Familial trigeminal neuralgia. 61 57
7387447 1980
3
Inherited tic douloureux. 61 57
4737685 1973
4
TRIGEMINAL NEURALGIA IN SIX MEMBERS OF ONE GENERATION. 61 57
14315671 1965
5
[Trigeminal neuralgia in three brothers of which two were twins]. 57 61
13794177 1959
6
Selective denervation of the corrugator supercilii muscle for the treatment of idiopatic trigeminal neuralgia purely paroxysmal distributed in the supraorbital and suprathrochlear dermatomes. 61 42
33663369 2021
7
Comparison of efficacy and safety of complementary and alternative therapies for primary trigeminal neuralgia: A protocol for a Bayesian network meta analysis. 42 61
33466199 2021
8
Trigeminal neuralgia recurrence: a comparison of microvascular decompression and percutaneous balloon compression: a five years follow-up study. 42 61
33656112 2021
9
BILATERAL TRIGEMINAL TIC: ITS ASSOCIATION WITH HEREDITY AND DISSEMINATED SCLEROSIS. 57
17856710 1936
10
Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. 54 61
11642720 2001
11
Transcriptional mRNA of bone morphogenetic proteins 2, 3, 4, and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. 54 61
11411255 2001
12
Meckel's Cave and Somatotopy of the Trigeminal Ganglion. 61
33516868 2021
13
The Stanford stereotactic radiosurgery experience on 7000 patients over 2 decades (1999-2018): looking far beyond the scalpel. 61
33799297 2021
14
Life-threatening complications after microvascular decompression procedure: Lessons from a consecutive series of 596 patients. 61
33775349 2021
15
Psychological status before and after surgery in patients with trigeminal neuralgia. 61
33676140 2021
16
Novel fluoroscopic landmark to significantly facilitate the visualization of foramen ovale in treating idiopathic trigeminal neuralgia. 61
33328267 2021
17
Subacute vision loss after microvascular decompression for trigeminal neuralgia. 61
33811522 2021
18
Microvascular decompression for trigeminal neuralgia attributable to the vertebrobasilar artery: decompression technique and significance of separation from the nerve root. 61
32901396 2021
19
Location of the abducens nerve stretched by a tortuous vertebrobasilar artery in trigeminal neuralgia. 61
33543330 2021
20
Orofacial pain education in dentistry: A path to improving patient care and reducing the population burden of chronic pain. 61
33098113 2021
21
Medical treatment of SUNCT and SUNA: a prospective open-label study including single-arm meta-analysis. 61
33361408 2021
22
Sphenopalatine ganglion block - a new treatment for burning mouth syndrome?: a case report. 61
33762189 2021
23
Microsurgical resection of petroclival meningiomas treated with stereotactic radiosurgery to address persistent post-treatment trigeminal pain. 61
33548878 2021
24
The Original Cushing Society: A Historical Review of the Senior Society's First 6 Meetings. 61
33307257 2021
25
A technique to facilitate the cannulation of the foramen ovale for balloon compression. 61
33783292 2021
26
Pain Management in Neurosurgery: Back and Lower Extremity Pain, Trigeminal Neuralgia. 61
33563380 2021
27
Petrosal Vein Involvement in Neurovascular Conflict in Trigeminal Neuralgia: Surgical Technique and Clinical Outcomes. 61
33377154 2021
28
Erratum to 'Gamma Knife Radiosurgery for Trigeminal Neuralgia: Role of Trigeminal Length and Pontotrigeminal Angle on Target Definition and on Clinical Effects' [World Neurosurgery. 142 (2020), e140-e150]. 61
33692007 2021
29
Comparison of first-time microvascular decompression with percutaneous surgery for trigeminal neuralgia: long-term outcomes and prognostic factors. 61
33751217 2021
30
Pre-Operative Decision Making in Microvascular Decompression for Trigeminal Neuralgia: A Survey of Practicing Neurosurgeons. 61
33798782 2021
31
Trigeminal neuralgia as the sole neurological manifestation of COVID-19: A case report. 61
33749854 2021
32
Population Pharmacokinetics of Vixotrigine in Healthy Volunteers and Subjects with Trigeminal Neuralgia, Painful Lumbosacral Radiculopathy and Erythromelalgia. 61
33782834 2021
33
Intravenous cannula used for continuous intraoral mandibular nerve block in trigeminal neuralgia. 61
33737280 2021
34
[Efficacy analysis of fully endoscopic microvascular decompression in primary trigeminal neuralgia via keyhole approach]. 61
33789367 2021
35
Endoscopic-assisted microvascular decompression for trigeminal neuralgia secondary to vertebrobasilar dolichoectasia: A case report. 61
33735736 2021
36
Efficacy and Safety of Radiofrequency Thermocoagulation with Different Puncture Methods for Treatment of V1 Trigeminal Neuralgia: A Prospective Study. 61
33740347 2021
37
Bipolar Pulsed Radiofrequency for Trigeminal Neuralgia: A Report of Two Cases. 61
32790964 2021
38
Localization of Foramen Ovale According to Bone Landmarks of the Splanchnocranium: Help for Transforaminal Surgical Approach to Trigeminal Neuralgia. 61
33705030 2021
39
Microvascular Transposition Without Teflon: A Single Institution's 17-Year Experience Treating Trigeminal Neuralgia. 61
33432975 2021
40
Facial pain beyond trigeminal neuralgia. 61
33661160 2021
41
The Integrity of the Substructure of the Corpus Callosum in Patients With Right Classic Trigeminal Neuralgia. 61
33704998 2021
42
The role of the P2X4 receptor in trigeminal neuralgia, a common neurological disorder. 61
33661807 2021
43
Masticatory Dysfunction After Computed Tomography-Guided Plasma Ablation vs. Radiofrequency Ablation on Gasserian Ganglion for Idiopathic Trigeminal Neuralgia: A Randomized Controlled Trial. 61
33175164 2021
44
Improving the accuracy of pre-operative evaluation of neurovascular conflict in trigeminal neuralgia using magnetic resonance subtraction. 61
33392731 2021
45
Trigeminal Neuralgia Secondary to Intracranial Neoplastic Lesions: a Case Series and Comprehensive Review. 61
33291153 2021
46
Balloon compression vs radiofrequency for primary trigeminal neuralgia: a randomized, controlled trial. 61
32947541 2021
47
Commentary: Petrosal Vein Involvement in Neurovascular Conflict in Trigeminal Neuralgia: Surgical Technique and Clinical Outcomes. 61
33448292 2021
48
The Epidemiology, Cause, and Prognosis of Painful Tic Convulsif Syndrome: An Individual Patient Data Analysis of 192 Cases. 61
33307261 2021
49
Multicompartmental epidermoid cyst causing chronic parotid gland and masticator space muscles atrophy. 61
33798775 2021
50
[Characteristics of clinical application of electroacupuncture therapy for peripheral neuropathy based on data mining]. 61
33798299 2021
Sources

Variations for Trigeminal Neuralgia

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Expression for Trigeminal Neuralgia

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Search GEO for disease gene expression data for Trigeminal Neuralgia.
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Pathways for Trigeminal Neuralgia

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Pathways related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Activation of cAMP-Dependent PKA 63
Show member pathways
 13.39 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
2
Cardiac conduction 65
Show member pathways
 12.68 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
3
G-Beta Gamma Signaling 63
Show member pathways
 12.61 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
4
Development HGF signaling pathway 23
Show member pathways
 12.55 NTRK1 NGF FOS ESR1 BDNF
5
Neuroscience 4
12.44 SCN9A SCN8A SCN4A SCN1A SCN11A SCN10A
6
Neuropathic Pain-Signaling in Dorsal Horn Neurons 63
Show member pathways
 12.25 TAC1 SCN9A SCN8A SCN4A SCN3A SCN1A
7
Inflammatory mediator regulation of TRP channels 36
Show member pathways
 12.14 TRPV1 TRPM8 TRPA1 NTRK1 NGF
8
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.02 TAC1 SLC6A4 NGF BDNF
9
L1CAM interactions 65
Show member pathways
 11.96 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
10
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 1
11.95 NTRK1 NGF FOS BDNF
11
Phase 0 - rapid depolarisation 65
Show member pathways
 11.57 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
12
Neurotrophic factor-mediated Trk receptor signaling 1
Show member pathways
 11.5 NTRK1 NGF BDNF
13
TRP channels 65
11.05 TRPV1 TRPM8 TRPA1
14
Interaction between L1 and Ankyrins 65
10.64 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
15
Activation of TRKA receptors 65
Show member pathways
 10.59 NTRK1 NGF
Sources

GO Terms for Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.21 TRPV1 TRPM8 TRPA1 SLC6A4 SCN9A SCN8A
2 plasma membrane GO:0005886 10.03 TRPV1 TRPM8 TRPA1 TAC1 SLC6A4 SCN9A
3 integral component of plasma membrane GO:0005887 10.01 TRPV1 TRPM8 TRPA1 SLC6A4 SCN9A SCN4A
4 neuron projection GO:0043005 9.8 TRPV1 SLC6A4 SCN9A P2RX3 FOS CALCA
5 neuronal cell body GO:0043025 9.73 TRPV1 TAC1 SCN1A P2RX3 NTRK1 CALCA
6 integral component of presynaptic membrane GO:0099056 9.61 SLC6A4 SCN10A P2RX3
7 voltage-gated sodium channel complex GO:0001518 9.5 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
8 axon initial segment GO:0043194 9.48 SCN8A SCN1A
9 node of Ranvier GO:0033268 9.46 SCN8A SCN1A
10 axon GO:0030424 9.44 TAC1 SCN9A SCN8A SCN4A SCN3A SCN1A

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.11 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN4A
2 ion transmembrane transport GO:0034220 10.06 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN3A
3 transmembrane transport GO:0055085 10.06 TRPV1 TRPM8 TRPA1 SLC6A4 SCN9A SCN8A
4 inflammatory response GO:0006954 10.03 TRPV1 TAC1 SCN9A FOS CALCA
5 regulation of ion transmembrane transport GO:0034765 10.02 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
6 response to drug GO:0042493 10.01 TRPA1 SLC6A4 SCN11A NTRK1 FOS
7 sodium ion transport GO:0006814 10 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.92 TRPV1 TAC1 ESR1 CALCA
9 sensory perception of pain GO:0019233 9.91 TRPV1 TRPA1 TAC1 SCN9A SCN10A NTRK1
10 response to toxic substance GO:0009636 9.84 SLC6A4 SCN9A FOS
11 cellular response to nerve growth factor stimulus GO:1990090 9.84 TRPV1 TAC1 NTRK1 CALCA
12 response to organic substance GO:0010033 9.83 TRPA1 SLC6A4 P2RX3
13 memory GO:0007613 9.83 SLC6A4 NGF BDNF
14 response to cold GO:0009409 9.83 TRPM8 TRPA1 P2RX3 FOS
15 modulation of chemical synaptic transmission GO:0050804 9.82 P2RX3 NGF BDNF
16 response to pain GO:0048265 9.8 TRPV1 TRPA1 TAC1 CALCA
17 cation transmembrane transport GO:0098655 9.8 TRPM8 SCN9A SCN8A SCN3A SCN1A SCN10A
18 response to heat GO:0009408 9.79 TRPV1 P2RX3 CALCA
19 peripheral nervous system development GO:0007422 9.77 SCN8A NGF BDNF
20 neurotrophin TRK receptor signaling pathway GO:0048011 9.76 NTRK1 NGF BDNF
21 sodium ion transmembrane transport GO:0035725 9.76 SLC6A4 SCN9A SCN8A SCN4A SCN3A SCN1A
22 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.75 TRPV1 NTRK1 CALCA
23 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.74 TRPA1 SCN1A NTRK1
24 behavioral response to pain GO:0048266 9.73 TRPV1 SCN9A P2RX3
25 nerve growth factor signaling pathway GO:0038180 9.72 NTRK1 NGF BDNF
26 thermoception GO:0050955 9.69 TRPV1 TRPM8 TRPA1
27 nerve development GO:0021675 9.67 NGF BDNF
28 negative regulation of heart rate GO:0010459 9.65 TRPV1 TAC1
29 response to temperature stimulus GO:0009266 9.64 TRPM8 P2RX3
30 positive regulation of collateral sprouting GO:0048672 9.64 NGF BDNF
31 urinary bladder smooth muscle contraction GO:0014832 9.63 TRPV1 P2RX3
32 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.61 TRPV1 TRPA1
33 behavioral response to formalin induced pain GO:0061368 9.59 P2RX3 NTRK1
34 membrane depolarization during action potential GO:0086010 9.5 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
35 neuronal action potential GO:0019228 9.23 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 10.01 TRPV1 TRPM8 TRPA1 SLC6A4 P2RX3 NTRK1
2 voltage-gated ion channel activity GO:0005244 9.87 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
3 sodium channel activity GO:0005272 9.8 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
4 voltage-gated sodium channel activity GO:0005248 9.7 SCN9A SCN8A SCN4A SCN3A SCN1A SCN11A
5 calcium channel activity GO:0005262 9.63 TRPV1 TRPM8 TRPA1
6 cation channel activity GO:0005261 9.61 TRPV1 TRPM8 SCN9A SCN8A SCN4A SCN3A
7 calcium-release channel activity GO:0015278 9.43 TRPV1 TRPA1
8 nerve growth factor receptor binding GO:0005163 9.37 NGF BDNF
9 ion channel activity GO:0005216 9.36 TRPV1 TRPM8 TRPA1 SCN9A SCN8A SCN4A
Sources

Sources for Trigeminal Neuralgia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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