Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):
(show top 50)
(show all 85)
# |
|
Name |
Status |
Phase |
Clinical Trials |
Cas Number |
PubChem Id |
1 |
|
Ropivacaine |
Approved |
Phase 4 |
|
84057-95-4 |
71273 175805 |
Synonyms:
(-)-1-Propyl-2',6'-dimethyl-2-piperidylcarboxyanilide
(-)-1-Propyl-2',6'-pipecoloxylidide
(+-)-Ropivacaine
(S)-(-)-1-Propyl-2',6'-pipecoloxylidide
(S)-(−)-1-PROPYL-2',6'-PIPECOLOXYLIDIDE
(S)-ROPIVACAINE
1 Propyl 2',6' pipecoloxylidide
1-Propyl-2',6'-dimethyl-2-piperidylcarboxyanilide
1-Propyl-2',6'-pipecoloxylidide
1-propyl-2',6'-pipecoloxylidide|AL-381|LEA-103|Naropin®|ropivacaine hydrochloride
AL-381
DL-Ropivacaine
LEA 103
LEA-103
L-N-N-Propylpipecolate-2,6-xylidide
L-N-N-Propylpipecolic acid-2,6-xylidide
Naropeine
|
Naropin
N-N-Propylpipecolate-2,6-xylidide
N-N-Propylpipecolic acid-2,6-xylidide
Racemic ropivacaine
rac-Ropivacaine
Ropivacaina
Ropivacaina [INN-Spanish]
Ropivacaina [Spanish]
Ropivacaine
Ropivacaine [INN]
Ropivacaine hydrochloride
Ropivacaine monohydrochloride
Ropivacaine monohydrochloride, (S)-isomer
Ropivacainum
Ropivacainum [INN-Latin]
S-Ropivacaine
|
|
2 |
|
Ketamine |
Approved, Vet_approved |
Phase 4 |
|
6740-88-1, 1867-66-9 |
3821 |
Synonyms:
(-)-Ketamine
(+-)-Ketamine
(±)-ketamine
(S)-(-)-Ketamine
(S)-Ketamine
2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone
2-(O-Chlorophenyl)-2-(methylamino)-cyclohexanone
Calipsol
Calypsol
CI 581 base
CLSTA 20
DL-Ketamine
Esketamine
Kalipsol
Ketaject
Ketalar
|
Ketalar base
Ketalar|ketamine HCl
Ketamina
KETAMINE
Kétamine
Ketamine base
Ketamine HCL
Ketamine hydrochloride
Ketaminum
Ketanest
Ketaset
Ketolar
L-Ketamine
NMDA
NSC-70151
Special K
Tekam
|
|
3 |
|
Ondansetron |
Approved, Withdrawn |
Phase 4 |
|
99614-02-5 |
4595 |
Synonyms:
A04AA01
Apo-ondansetron
DESMETHYLONDANSETRON
Dihydrate, ondansetron monohydrochloride
EUR-1025
GR-38032
GR-38032F
GR-38032F/GR-38032|ondansetron hydrochloride|ondansetron hydrochloride dihydrate|Zofran®
Hydrochloride, ondansetron
Monohydrochloride dihydrate, ondansetron
Monohydrochloride, ondansetron
Novo-ondansetron
ONDANSETRON
Ondansetron hydrochloride
|
Ondansetron monohydrochloride
Ondansetron monohydrochloride dihydrate
Ondansetron, (+,-)-isomer
Ondansetron, (R)-isomer
Ondansetron, (S)-isomer
PHL-ondansetron
PMS-ondansetron
Ratio-ondansetron
Sandoz ondansetron
Zofran
Zofran odt
Zophren
Zudan
ZUPLENZ
|
|
4 |
|
Sufentanil |
Approved, Investigational |
Phase 4 |
|
56030-54-7 |
41693 |
Synonyms:
Chronogesic
Citrate, sufentanil
Curasan brand OF sufentanil citrate
Curasan, sufentanil
Hameln brand OF sufentanil citrate
IDS-NS-001
Janssen brand OF sufentanil citrate
N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide
N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide
R-30730
Ratiopharm brand OF sufentanil citrate
Sufenta
Sufenta®|sufentanil citrate|Zalviso®
Sufentanil
Sufentanil citrate
|
Sufentanil curasan
Sufentanil hameln
Sufentanil ratiopharm
Sufentanil-hameln
SufentanilHameln
Sufentanilo
Sufentanil-ratiopharm
SufentanilRatiopharm
Sufentanilum
Sufentanilum [INN-Latin]
Sufentanyl
Sulfentanil
Sulfentanil Citrate
Sulfentanyl
Taylor brand OF sufentanil citrate
|
|
5 |
|
Carbamazepine |
Approved, Investigational |
Phase 4 |
|
298-46-4 |
2554 |
Synonyms:
5-Carbamoyl-5H-dibenz(b,F)azepine
5-Carbamoyl-5H-dibenz[b,F]azepine
5-Carbamoyl-5H-dibenzo(b,F)azepine
5-Carbamyl-5H-dibenzo(b,F)azepine
5H-Dibenz(b,F)azepine-5-carboxamide
Amizepine
Apo-Carbamazepine
ARBIL MR
Atretol
Biston
CALEPSIN
calepsin|Carnexiv®|Tegretol®
CARBAGEN SR
Carbamazepen
Carbamazepin
Carbamazepina
Carbamazepine
Carbamazépine
Carbamazepine acetate
Carbamazepine anhydrous
Carbamazepine dihydrate
Carbamazepine hydrochloride
Carbamazepine L-tartrate (4:1)
Carbamazepine phosphate
Carbamazepine sulfate (2:1)
Carbamazepinum
Carbamezepine
CARBATROL
Carbazepin
Carbazepine
Carbelan
Carnexiv
CBZ
EPIMAZ
|
EPIMAZ RET
Epitol
Equetro
Finlepsin
G-32883
GEIGY 32883
Karbamazepin
Lexin
Neurotol
Novo-Carbamaz
NSC-169864
Nu-Carbamazepine
Sirtal
SIRTAL RET
Stazepin
Stazepine
Taro-Carbamazepine
Taro-Carbamazepine Cr
TEG111
Tegretal
Tegretol
TEGRETOL CHEWTAB
Tegretol Chewtabs
Tegretol Cr
TEGRETOL PROLONGED RELEASE
TEGRETOL XR
TEGRETOL-XR
Telesmin
TERIL
TERIL RET
Timonil
TIMONIL 200 RET
TIMONIL 400 RET
|
|
6 |
|
Lidocaine |
Approved, Vet_approved |
Phase 4 |
|
137-58-6 |
3676 |
Synonyms:
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-2ETN-2MePhAcN
a-Diethylamino-2,6-dimethylacetanilide
ALGRX 3268
ALGRX-3268
ALPHACAINE
alpha-Diethylamino-2,6-dimethylacetanilide
ANESTACON
Astrazeneca brand OF lidocaine
Dalcaine
Dentipatch
Dilocaine
EMBOLEX
IONTOCAINE
Jenapharm brand OF lidocanine hydrochloride
L-Caine
Lidocaina
Lidocaína
LIDOCAINE
Lidocaine carbonate
Lidocaine carbonate (2:1)
Lidocaine hydrocarbonate
Lidocaine hydrochloride
Lidocaine monoacetate
Lidocaine monohydrochloride
|
Lidocaine monohydrochloride, monohydrate
Lidocaine sulfate (1:1)
Lidocainum
LIDOCATON
Lidoderm
LIDOPEN
Lignocaine
LIGNOCAINE HCL
LIGNOSTAB
LMX 4
Novocol brand OF lidocaine hydrochloride
NSC-40030
Octocaine
ORAQIX
Strathmann brand OF lidocaine hydrochloride
VAGISIL
Xylesthesin
Xylocaine
Xylocaine®
Xylocitin
XYLODASE
Xyloneural
XYLOTOX
ZTLIDO
Α-diethylamino-2,6-dimethylacetanilide
|
|
7 |
|
Zileuton |
Approved, Investigational, Withdrawn |
Phase 4 |
|
111406-87-2 |
60490 |
Synonyms:
(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea
(±)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea
A-64077
A-64077|ZYFLO®
Abbot 64077
ABBOTT-64077
Leutrol
N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea
|
N-[1-(Benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea
Zileuton
Zileutón
Zileutonum
Zileutonum [INN-Latin]
Zyflo
ZYFLO CR
|
|
8 |
|
Analgesics |
|
Phase 4 |
|
|
|
9 |
|
Neurotransmitter Agents |
|
Phase 4 |
|
|
|
10 |
|
Antipsychotic Agents |
|
Phase 4 |
|
|
|
11 |
|
Antiemetics |
|
Phase 4 |
|
|
|
12 |
|
Gastrointestinal Agents |
|
Phase 4 |
|
|
|
13 |
|
Analgesics, Opioid |
|
Phase 4 |
|
|
|
14 |
|
Excitatory Amino Acid Antagonists |
|
Phase 4 |
|
|
|
15 |
|
Narcotics |
|
Phase 4 |
|
|
|
16 |
|
Dsuvia |
|
Phase 4 |
|
|
|
17 |
|
Anti-Anxiety Agents |
|
Phase 4 |
|
|
|
18 |
|
Anesthetics, Intravenous |
|
Phase 4 |
|
|
|
19 |
|
Anesthetics, General |
|
Phase 4 |
|
|
|
20 |
|
Anesthetics, Dissociative |
|
Phase 4 |
|
|
|
21 |
|
Psychotropic Drugs |
|
Phase 4 |
|
|
|
22 |
|
Anti-Arrhythmia Agents |
|
Phase 4 |
|
|
|
23 |
|
Anesthetics, Local |
|
Phase 4 |
|
|
|
24 |
|
Anesthetics |
|
Phase 4 |
|
|
|
25 |
|
Leukotriene Antagonists |
|
Phase 4 |
|
|
|
26 |
|
Immunoglobulins |
|
Phase 4 |
|
|
|
27 |
|
Antibodies, Blocking |
|
Phase 4 |
|
|
|
28 |
|
Antibodies |
|
Phase 4 |
|
|
|
29 |
|
Serotonin |
Investigational, Nutraceutical |
Phase 4 |
|
50-67-9 |
5202 |
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5 Hydroxytryptamine
5-HT
5-HT|serotonin
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
5-Hydroxy-tryptamine
|
Antemovis
DS Substance
Enteramin
Enteramine
Hippophaine
Hydroxytryptamine
SEROTONIN
Serotonine
sérotonine
Thrombocytin
Thrombotonin
|
|
30 |
|
Lamotrigine |
Approved, Investigational |
Phase 2, Phase 3 |
|
84057-84-1 |
3878 |
Synonyms:
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine
BW 430C
BW-430C
Crisomet
GIZORD
GW 273293
Labileno
Lamictal
LAMICTAL CD
LAMICTAL ODT
|
LAMICTAL XR
Lamictal®
Lamictin
Lamiktal
Lamotrigina
Lamotrigina [Spanish]
Lamotrigine
Lamotriginum
Lamotriginum [Latin]
QIN
QÍN
|
|
31 |
|
Amifostine |
Approved, Investigational |
Phase 3 |
|
20537-88-6 |
2141 |
Synonyms:
Acid, aminopropylaminoethylthiophosphoric
Alza brand OF amifostine
Amifostina
AMIFOSTINE
Amifostine alza brand
Amifostine anhydrous
Amifostine disodium salt
AMIFOSTINE DISULFIDE
Amifostine essex brand
Amifostine ethiofos
Amifostine lilly brand
Amifostine monohydrate
Amifostine monohydrochloride
Amifostine schering-plough brand
Amifostine trihydrate
Amifostinum
Aminopropyl aminoethylthiophosphate
Aminopropylaminoethyl thiophosphate
Aminopropylaminoethylthiophosphate
Aminopropylaminoethylthiophosphoric acid
Anhydrous, amifostine
Anhydrous, ethiofos
|
Apaetp
Disodium salt, amifostine
Essex brand OF amifostine
Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihydrate
Ethiofos
Ethiofos anhydrous
Ethyol
Gammaphos
Lilly brand OF amifostine
Monohydrate, amifostine
Monohydrochloride, amifostine
NSC-296961
S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric acid
SAPEP
Schering plough brand OF amifostine
Schering-plough brand OF amifostine
Trihydrate, amifostine
US bioscience brand OF amifostine
WR-1065
WR-2721
WR-2721 TRIHYDRATE
YM-08310
|
|
32 |
|
Antipain |
Experimental |
Phase 2, Phase 3 |
|
37691-11-5 |
|
33 |
|
Calcium, Dietary |
|
Phase 2, Phase 3 |
|
|
|
34 |
|
calcium channel blockers |
|
Phase 2, Phase 3 |
|
|
|
35 |
|
Protective Agents |
|
Phase 3 |
|
|
|
36 |
|
Radiation-Protective Agents |
|
Phase 3 |
|
|
|
37 |
|
Calcium |
Nutraceutical |
Phase 2, Phase 3 |
|
7440-70-2 |
271 |
Synonyms:
Ca
Ca(2+)
Ca2+
Calcio
CALCIUM
Calcium element
|
CALCIUM ion
Calcium(2+)
Calcium, doubly charged positive ion
Calcium, elemental
Elemental calcium
Kalzium
|
|
38 |
|
Erenumab |
Approved, Investigational |
Phase 2 |
|
1582205-90-0 |
|
Synonyms:
AIMOVIG
Aimovig®|AMG 334|AMG-334|erenumab-aooe
AMG 334
|
AMG-334
ERENUMAB
ERENUMAB-AOOE
|
|
39 |
|
Salmon calcitonin |
Approved, Investigational |
Phase 2 |
|
47931-85-1 |
155817456 |
Synonyms:
CALCITONIN (SALMON SYNTHETIC)
Calcitonin salmon
CALCITONIN SALMON RECOMBINANT
Calcitonin, salmon
Calcitonina salmón sintética
|
Calcitonin-salmon
CT (salmon)|Miacalcin®
FORTICAL
Recombinant salmon calcitonin
Salmon calcitonin
|
|
40 |
|
Cathine |
Approved, Experimental, Illicit, Vet_approved, Withdrawn |
Phase 2 |
|
14838-15-4, 492-39-7 |
131954576 4786 26934 |
Synonyms:
(+-)-Norephedrine
(+)-Norpseudoephedrine
(+-)-Phenylpropanolamine
2-AMINO-1-PHENYLPROPAN-1-OL
Cathina
Cathine
Cathinum
D-Cathine
Dexatrim
DL-Norephedrine
DL-Phenylpropanolamine
D-Norephedrine
d-Norpseudoephedrine
d-Nor-psi-ephedrine
FENILPROPANOLAMINA
Hydriatine
Hydrochloride, phenylpropanolamine
Katine
L-NOREPHEDRINE
L-Phenyl propanolamine
|
Mucorama
Nobese
NOREPHEDRIN
Norephedrine
Obestat
PHENYLPROPANOLAMIN
Phenylpropanolamina
Phenylpropanolamine
PHÉNYLPROPANOLAMINE
Phenylpropanolamine hydrochloride
PHENYLPROPANOLAMINUM
PPA
Prestwick_388
Prolamine
Propadrine
Propagest
Pseudonorephedrine
psi-Norephedrine
Triaminic DM
Î’-HYDROXYAMPHETAMINE
|
|
41 |
|
Guaifenesin |
Approved, Investigational, Vet_approved |
Phase 2 |
|
93-14-1 |
3516 |
Synonyms:
3-(2-Methoxyphenoxy)-1,2-propanediol
3-(O-Methoxyphenoxy)-1,2-propanediol
3-(O-Methoxyphenoxy)-propanediol-1,2
3-O-Methoxyphenoxypropane 1:2-diol
Actifed C
Aeronesin
a-Glyceryl guaiacol ether
a-Glyceryl guaiacolate ether
alpha-Glyceryl guaiacol ether
alpha-Glyceryl guaiacolate ether
Amonidren
Amonidrin
AMONIDRON
Aresol
Benylin-e
Breonesin
Bronchol
CVT-2534
Ether, guaiacol glyceryl
FAMEL
FRANOLYN CHESTY
GECOLATE
Glycerin ether
Glycerin guaiacolate
Glycero-guaiacol ether
Glycerol a-(2-methoxyphenyl) ether
Glycerol a-(O-methoxyphenyl)ether
Glycerol a-guaiacyl ether
Glycerol a-guiacyl ether
Glycerol a-monoguaiacol ether
Glycerol guaiacolate
Glycerol mono(2-methoxyphenyl) ether
Glycerol-a-guajakolether
Glycerol-alpha-guajakolether
Glyceryl ether, guaiacol
Glyceryl guaiacol
Glyceryl guaiacol ether
Glyceryl guaiacolate
Glyceryl guaiacolate ether
Glyceryl guaiacyl ether
Glyceryl guaicolate
Glyceryl guiacolate
Glycerylguaiacol
|
Guaiacol glycerol ether
Guaiacol glyceryl ether
Guaiacolate, glycerol
Guaiacolglicerinetere
Guaiacuran
Guaiacurane
Guaiacyl glyceryl ether
Guaiamar
Guaianesin
Guaicol glycerine ether
Guaicol glyceryl ether
Guaifenesin
GUAIFENESIN OR GUAIPHENESIN
Guaifenesina
Guaifenesine
Guaiphenesin
Guaiphenesine
Guaiphenezine
Guaiphesin
Guiatuss
HUMABID
Humibid
Hustosil
Hytuss
LIQUFRUTA
Methoxypropanediol
Methphenoxydiol
Metossipropandiolo
MUCINEX
NIROLEX FOR CHESTY COUGH DECONGESTANT
NSC-62112
O-Methoxyphenyl glyceryl ether
Organidin NR
p-Cresyl acetate
Pneumomist
Propanosedyl
Reduton
Robitussin
Scott tussin
Scott-tussin
ScottTussin
TIXYLIX CHESTY COUGH
|
|
42 |
|
Dextromethorphan |
Approved |
Phase 2 |
|
125-71-3 |
5362449 5360696 |
Synonyms:
(-)-3-Methoxy-17-methylmorphinan
(-)-3-Methoxy-N-methylmorphinan
(+)-DEXTROMETHORPHAN
(9S,13S,14S)-3-METHOXY-17-METHYLMORPHINAN
Antussan
Balminil DM
Balminil DM Children
Bayer select flu relief
Bayer select head & chest cold
Bayer select night time cold
Benylin Adult Formula Cough Suppressant
Benylin DM
Benylin DM 12 Hour
Benylin DM for Children
Benylin DM for Children 12 Hour
Benylin Pediatric Cough Suppressant
Calmylin #1
Canfodion
Cerose-DM
Chloraseptic DM
Contac day & night cold/flu day caplets
Contac jr. non-drowsy formula
Contac nighttime cold medicine
Contac severe cold formula maximum strength
Contac severe cold formula non-drowsy
Coricidin syrup
Cosylan
Cough-X
Creo-Terpin
Delsym
Delsym Cough Formula
delta-Methorphan
Demorphan
Demorphan hydrobromide
Demorphine
Destrometerfano
Destrometerfano [Dcit]
DEX
DEXTROMETHORFAN
Dextromethorfan [Czech]
DEXTROMETHORPHAN
Dextromethorphan bromhydrate
Dextromethorphan bromide
Dextromethorphan hydrobromide
Dextromethorphan hydrobromide monohydrate
Dextromethorphan hydrobromide oros tablets
Dextromethorphan hydrobromide, (+-)-isomer
Dextromethorphan hydrobromide, monohydrate
Dextromethorphan hydrochloride
Dextromethorphan, (+-)-isomer
DEXTROMÉTHORPHANE
DEXTROMETHORPHANUM
DEXTROMETORFANO
Dextrometorfano [INN-Spanish]
Dextrometorphan
Dextromorphan
Dexyromethorphan
Diabe-Tuss DM Syrup
Dimacol
DIMETANE-DX
Dimetapp DM
DM
D-Methorphan
D-Methorphan hydrobromide
Dormetan
Dormethan
Drixoral cough
Drixoral cough & congestion
Drixoral cough & sore throat
DXM
|
Endotussin-NN
Endotussin-NN pediatric
Hihustan M.
Hold
Hold DM
Hydrobromide, dextromethorphan
Hydrochloride, dextromethorphan
Koffex DM
L-3-Methoxy-17-methylmorphinan
Levomethorphan
Levomethorphan [Ban:Dcf:Inn]
Levomethorphane
Levomethorphane [INN-French]
Levomethorphanum
Levomethorphanum [INN-Latin]
Levometorfano
Levometorfano [INN-Spanish]
L-Methorphan
Medicon
Methorate
Methorate Hydrobromide
Methorphan
Metrorat
Naldecon-DX
Novahistex DM
Novahistine DM
Ornex severe cold formula
Orthoxicol
PediaCare 1
PediaCare cough-cold formula
Pertussin CS Children's Strength
Pertussin DM Extra Strength
Prestwick_686
Racemethorphan
Robitussin CF
Robitussin cold & cough
Robitussin cough calmers
Robitussin DM
Robitussin maximum strength cough
Robitussin Maximum Strength Cough Suppressant
Robitussin Pediatric
Robitussin pediatric cough
Robitussin pediatric cough & cold
Robitussin Pediatric Cough Suppressant
Robitussin pediatric night relief
Romilar
Rondec DM
Ru-tuss expectorant
St. joseph cough syrup
Sucrets 4 Hour Cough Suppressant
Sudafed cough syrup
Triaminic
Triaminic DM Long Lasting for Children
Trind-DM
Trocal
Tusilan
Tussade
Tussar DM
Tussi-organidin
Tussi-organidin DM NR
Tussi-organidin DM-S NR
Tylenol cold and flu multi-symptom
Tylenol cold and flu no drowsiness
Tylenol cold no drowsiness
Tylenol cough + decongestant liquid
Tylenol cough liquid
Tylenol flu no drowsiness gelcaps
Vicks 44 Cough Relief
Viro-med
Δ-methorphan
|
|
43 |
|
Topiramate |
Approved |
Phase 2 |
|
97240-79-4 |
5284627 |
Synonyms:
[(1R,2S,6S,9R)-4,4,11,11-TETRAMETHYL-3,5,7,10,12-PENTAOXATRICYCLO[7.3.0.0^{2,6}]DODECAN-6-YL]METHYL SULFAMATE
2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulfamic acid
2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulphamate
2,3:4,5-Bis-O-(1-methylethylidene)-b-D-fructopyranose sulphamic acid
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamic acid
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulphamate
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulphamic acid
2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamic acid
2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulphamate
2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulphamic acid
2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulfamic acid
2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulphamate
2,3:4,5-Di-O-isopropylidene-b-D-fructopyranose sulphamic acid
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamic acid
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulphamate
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulphamic acid
2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulfamic acid
2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulphamate
2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose sulphamic acid
2,3-4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
|
Epitomax
epitomax|Eprontia® (liquid formulation)|MCN-4853|RWJ-17021|Topamax®
MCN-4853
QUDEXY XR
RWJ-17021
RWJ-17021-000
Tipiramate
Tipiramate [French]
Tipiramato
Tipiramato [Spanish]
Tipiramic acid
Topamax
Topamax sprinkle
TOPIRAMATE
topiramate tablet
Topiramato
Topiramato [INN-Spanish]
Topiramatum
Topiramatum [INN-Latin]
Topiramic acid
Topomax
TPM
Trokendi XR
USL255
USL-255
|
|
44 |
|
Guanfacine |
Approved, Investigational |
Phase 2 |
|
29110-47-2 |
3519 |
Synonyms:
Estulic
Estulic®|Intuniv®|Tenex®
ETC141
GUANFACINA
GUANFACINE
Guanfacine hydrochloride
Guanfacine monohydrochloride
|
GUANFACINUM
Hydrochloride, guanfacine
INTUNIV
Monohydrochloride, guanfacine
SPD 503
Tenex
|
|
45 |
|
Acetylcholine |
Approved, Investigational |
Phase 2 |
|
51-84-3 |
187 |
Synonyms:
[2-(ACETYLOXY)ETHYL]TRIMETHYLAZANIUM
2-(Acetyloxy)-N,N,N-trimethylethanaminium
2-ACETOXYETHYL(TRIMETHYL)AMMONIUM
2-ACETYLOXYETHYL(TRIMETHYL)AMMONIUM
2-ACETYLOXYETHYL(TRIMETHYL)AZANIUM
Acetilcolina cusi
Acetyl choline ion
Acetylcholine
Acetylcholine bromide
Acetylcholine cation
Acetylcholine chloride
Acetylcholine fluoride
Acetylcholine hydroxide
Acetylcholine iodide
Acetylcholine L tartrate
Acetylcholine L-tartrate
Acetylcholine perchlorate
Acetylcholine picrate
Acetylcholine picrate (1:1)
Acetylcholine sulfate (1:1)
ACETYLCHOLINE, ACH
Acetylcholinium: acetyl-choline
|
ACh
ACh|E1001|O-acetylcholine
Alcon brand OF acetylcholine chloride
Azetylcholin
Bournonville brand OF acetylcholine chloride
Bromide, acetylcholine
Bromoacetylcholine
Chloroacetylcholine
Choline acetate
Choline acetate (ester)
Choline acetic acid
Ciba vision brand OF acetylcholine chloride
Cusi, acetilcolina
E1001
Fluoride, acetylcholine
Hydroxide, acetylcholine
Iodide, acetylcholine
Iolab brand OF acetylcholine chloride
L-Tartrate, acetylcholine
Miochol
O-Acetylcholine
Perchlorate, acetylcholine
|
|
46 |
|
Glycerin |
Approved, Investigational |
Phase 1, Phase 2 |
|
56-81-5 |
753 |
Synonyms:
(2,5-Dihydroxyphenyl)-acetate
(2,5-Dihydroxyphenyl)-acetic acid
(2E)-2-Butenedioate
(2E)-2-Butenedioic acid
(2E)-But-2-enedioate
(2E)-But-2-enedioic acid
(e)-2-Butenedioate
(e)-2-Butenedioic acid
1,2,3-Propanetriol
1,2,3-Trihydroxypropane
2-(3,6-DIHYDROXYPHENYL)acetate
2-(3,6-DIHYDROXYPHENYL)acetIC ACID
2-(e)-Butenedioate
2-(e)-Butenedioic acid
2,5-Dihydroxy-alpha-toluate
2,5-Dihydroxy-alpha-toluic acid
2,5-Dihydroxy-a-toluate
2,5-Dihydroxy-a-toluic acid
2,5-Dihydroxy-benzeneacetate
2,5-Dihydroxy-benzeneacetic acid
2,5-Dihydroxyphenylacetate
2,5-Dihydroxyphenylacetic acid
Acid, homogentisic
Alcapton
Allomaleate
Allomaleic acid
alpha-delta-Glucopyranuronic acid
alpha-delta-Glucuronic acid
alpha-D-Glucopyranuronic acid
alpha-D-Glucuronic acid
Ammonium fumarate
Boletate
Boletic acid
Bulbold
Concentrated glycerin
Cristal
D-(+)-Glucuronate
D-(+)-Glucuronic acid
delta-(+)-Glucuronate
delta-(+)-Glucuronic acid
delta-Glucuronate
D-Glucuronate
e 422
e297
Emery 916
FC 33
Fumarate
Fumarsaeure
Furamag
GCU
GlcAa
GlcAalpha
|
Glucosiduronate
Glucosiduronic acid
Glucuronate
Glucuronic acid
Glyceol opthalgan
Glycerin
Glycerin, anhydrous
Glycerin, concentrated
Glycerin,anhydrous
Glycerine
glycérine
Glycerinum
Glyceritol
Glycerol
glycérol
Glycerolum
Glycyl alcohol
Glyrol
Glysanin
Glyzerin
Gro
Homogentisate
Homogentisate acid
Homogentisinate
Homogentisinic acid
IFP
Incorporation factor
Lichenate
Lichenic acid
Mackstat H 66
Mafusol
Magnesium fumarate
Melanic acid
Monoctanoin component D
Oelsuess
Ölsüß
Osmoglyn
Pricerine 9091
Propanetriol
RG-S
Sodium fumarate
trans-1,2-Ethylenedicarboxylate
trans-1,2-Ethylenedicarboxylic acid
trans-2-Butenedioate
trans-2-Butenedioic acid
trans-But-2-enedioate
trans-But-2-enedioic acid
trans-Butenedioate
trans-Butenedioic acid
Trihydroxypropane
Tryhydroxypropane
|
|
47 |
|
Calcitonin gene-related peptide |
Investigational |
Phase 2 |
|
83652-28-2 |
91976570 |
Synonyms:
2-{[2-({6-amino-2-[(2-{[2-({2-[(2-{[2-({[1-(2-{[2-({2-[(2-{[6-amino-2-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-({2-[(2-{[2-({2-[({19-[(2-amino-1-hydroxypropylidene)amino]-16-(carboxymethyl)-6,9,12,15,18-pentahydroxy-7,13-bis(1-hydroxyethyl)-10-methyl-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaen-4-yl}(hydroxy)methylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1,3-dihydroxybutylidene]amino}-1-hydroxy-3-(1H-imidazol-5-yl)propylidene)amino]-5-carbamimidamido-1-hydroxypentylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-1,3-dihydroxypropylidene}amino)-5-carbamimidamido-1-hydroxypentylidene]amino}-1,3-dihydroxypropylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxyethylidene]amino}-1-hydroxy-3-methylbutylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxyhexylidene]amino}-1-hydroxy-3-(C-hydroxycarbonimidoyl)propylidene)amino]-1-hydroxy-3-(C-hydroxycarbonimidoyl)propylidene}amino)-1-hydroxy-3-phenylpropylidene]amino}-3-methylbutanoyl)pyrrolidin-2-yl](hydroxy)methylidene}amino)-1,3-dihydroxybutylidene]amino}-1-hydroxy-3-(C-hydroxycarbonimidoyl)propylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxyethylidene]amino}-1,3-dihydroxypropylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxypropylidene]amino}-3-phenylpropanoate
Calcitonin gene related peptide
Calcitonin-gene-related peptide
|
|
|
48 |
|
Calcitonin |
|
Phase 2 |
|
|
|
Synonyms:
4-{[1-({1-[(5-amino-1-{[1-({1-[(1-{[1-(2-{[4-carbamimidamido-1-({2-hydroxy-1-[(1-{[2-hydroxy-1-({[(2-hydroxy-1-{[({3-hydroxy-1-[2-(C-hydroxycarbonimidoyl)pyrrolidin-1-yl]-1-oxobutan-2-yl}-C-hydroxycarbonimidoyl)methyl]-C-hydroxycarbonimidoyl}ethyl)-C-hydroxycarbonimidoyl]methyl}-C-hydroxycarbonimidoyl)propyl]-C-hydroxycarbonimidoyl}-2-(C-hydroxycarbonimidoyl)ethyl)-C-hydroxycarbonimidoyl]propyl}-C-hydroxycarbonimidoyl)butyl]-C-hydroxycarbonimidoyl}pyrrolidin-1-yl)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-C-hydroxycarbonimidoyl}-2-hydroxypropyl)-C-hydroxycarbonimidoyl]-3-(C-hydroxycarbonimidoyl)propyl}-C-hydroxycarbonimidoyl)-3-methylbutyl]-C-hydroxycarbonimidoyl}pentyl)-C-hydroxycarbonimidoyl]-2-(1H-imidazol-5-yl)ethyl}-C-hydroxycarbonimidoyl)-3-methylbutyl]-C-hydroxycarbonimidoyl}-4-({2-[(2-{[2-({6-amino-2-[(2-{[2-({2-[({22-amino-6,9,12,15,18,21-hexahydroxy-16-[(C-hydroxycarbonimidoyl)methyl]-7-(1-hydroxyethyl)-10,19-bis(hydroxymethyl)-13-(2-methylpropyl)-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosa-5,8,11,14,17,20-hexaen-4-yl}(hydroxy)methylidene)amino]-1-hydroxy-3-methylbutylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1-hydroxyethylidene)amino]-1-hydroxyhexylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-1,3-dihydroxypropylidene)amino]-1-hydroxy-4-(C-hydroxycarbonimidoyl)butylidene}amino)butanoate
Calcihexal
Calcimar
CALCITARE
CALCITONIN
Calcitonin salmon
CALSYNAR
Cibacalcin
Forcaltonin
|
Fortical
Miacalcic
Miacalcin
Recombinant salmon calcitonin
Salcatonin
Salmon calcitonin
Salmon calcitonin (1-32)
Synthetic salmon calcitonin
|
|
49 |
|
Katacalcin |
|
Phase 2 |
|
|
16172926 |
50 |
|
Chlorpheniramine, phenylpropanolamine drug combination |
|
Phase 2 |
|
|
|
Interventional clinical trials:
(show top 50)
(show all 85)
# |
Name |
Status |
NCT ID |
Phase |
Drugs |
1 |
Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression |
Unknown status |
NCT03152955 |
Phase 4 |
Ketamine;ondansetron;Sufentanil |
2 |
Examining the Efficacy of Low Intensity Low Frequency Surface Acoustic Wave Ultrasound(LILF/SAWU) in Trigeminal Neuralgia Pain |
Completed |
NCT01447108 |
Phase 4 |
|
3 |
The PATCH Trial: Effectiveness and Safety of 5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia |
Recruiting |
NCT04570293 |
Phase 4 |
5% lidocaine medicated plaster;vehicle plaster |
4 |
Comparative Efficacy of Carbamazepine Versus Oxcarbazepine in Treatment of Trigeminal Neuralgia- a Randomized Controlled Clinical Study |
Recruiting |
NCT04996199 |
Phase 4 |
Oxcarbazepine;Carbamazepine |
5 |
Anti-CGRP Neutralizing Antibody for Modulation of Neurogenic Inflammation in Trigeminal and Glossopharyngeal Pain Associated With Small Fiber Neuropathy/Fibromyalgia |
Active, not recruiting |
NCT04158752 |
Phase 4 |
Galcanezumab |
6 |
Pilot Study of Oxtellar XR (Oxcarbazepine Extended Release) in Neurology Patients With Trigeminal Neuralgia |
Withdrawn |
NCT03374709 |
Phase 4 |
Oxtellar XR 150Mg Extended Release Tablet |
7 |
The Efficacy and Safety of Botulinum Toxin for the Treatment of Trigeminal Neuralgia: Comparison of Two Different Treatment Methods |
Unknown status |
NCT03331913 |
Phase 3 |
Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved) |
8 |
Lamotrigine in Trigeminal Neuralgia: Efficacy and Safety in Comparison With Carbamazepine |
Completed |
NCT00913107 |
Phase 2, Phase 3 |
Lamictal®;Tegretol® |
9 |
A Phase II/III, Multicentre, 8-week run-in Phase Followed by a 12-week, Prospective, Parallel-group, Double-blind, Randomized Withdrawal, Placebo-controlled Study, With a 52 Week Open Label Extension, to Evaluate the Efficacy and Safety of Daily 1.5 to 3.5 mg Basimglurant in Patients With Pain Associated With Trigeminal Neuralgia With Suboptimal Response to Their Current Anti-pain Therapy. |
Recruiting |
NCT05217628 |
Phase 2, Phase 3 |
Basimglurant |
10 |
A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia |
Not yet recruiting |
NCT03070132 |
Phase 3 |
BIIB074;Placebo |
11 |
A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia |
Not yet recruiting |
NCT03637387 |
Phase 3 |
BIIB074;Placebo |
12 |
A Randomized, Placebo-controlled Trial of Amifostine for Prevention of Facial Numbness in Patients Receiving Stereotactic Radiosurgery for Trigeminal Neuralgia |
Terminated |
NCT01364259 |
Phase 3 |
Amifostine |
13 |
Phase II Double Blind, Randomized, Placebo Controlled, Safety and Efficacy Study of ATNC05 in Patients With Atypical Facial Pain With an Open-Label Extension Phase for Nonresponders |
Withdrawn |
NCT01920087 |
Phase 2, Phase 3 |
ATNC05;Placebo |
14 |
Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception |
Withdrawn |
NCT00349050 |
Phase 2, Phase 3 |
|
15 |
A Prospective Study on Efficacy of Hyperbaric Oxygenation Treatment for Patients With Trigeminal Neuralgia: a Randomized, Double-Blind, Mock Hyperbaric Chamber -Controlled, Parallel-Group Trial |
Unknown status |
NCT00866424 |
Phase 1, Phase 2 |
|
16 |
A Placebo-Controlled, Double-Blind, Randomized, Proof-of-Concept Study to Evaluate the Efficacy and Tolerability of Erenumab in Patients With Trigeminal Neuralgia |
Unknown status |
NCT04054024 |
Phase 2 |
Erenumab;Placebos |
17 |
Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. |
Completed |
NCT02662972 |
Phase 1, Phase 2 |
Botulinum Toxin Type A |
18 |
A Placebo-Controlled, Single-Blind Study Evaluating the Safety and Efficacy of Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia |
Completed |
NCT02473016 |
Phase 2 |
Carbon Dioxide Drug Delivery System (CDDS) |
19 |
A Phase IIa Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Safety and Efficacy of CNV1014802 in Patients With Trigeminal Neuralgia |
Completed |
NCT01540630 |
Phase 2 |
CNV1014802;Placebo |
20 |
Clinical Trials in Orofacial Neuralgias |
Completed |
NCT00001725 |
Phase 2 |
Dextromethorphan |
21 |
Paresthesia-free Peripheral Nerve Field Stimulation for Trigeminal Neuralgia: a Double-blinded, Randomized Trial (FreeST Trial) |
Recruiting |
NCT05615714 |
Phase 1, Phase 2 |
|
22 |
A Randomized, Double-Blind, 2-Way Crossover Trial to Assess the Efficacy of Guanfacine and Lidocaine Combination Versus Lidocaine Alone in Trigeminal Nerve Block for Pain Management in Painful Trigeminal Neuropathy Patients |
Recruiting |
NCT03865940 |
Phase 2 |
Lidocaine;Guanfacine |
23 |
BHV3000-202: Phase 2: A Double-Blind, Placebo Controlled, Crossover Trial of BHV-3000 (Rimegepant) for Treatment Refractory Trigeminal Neuraligia |
Recruiting |
NCT03941834 |
Phase 2 |
Rimegepant;Placebo |
24 |
Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique |
Terminated |
NCT02624661 |
Phase 1, Phase 2 |
Glycerol |
25 |
A Randomized, Double-Blind, Placebo-Controlled, Add-on Therapy Study of Xeomin (Incobotulinumtoxina) Versus Placebo in the Treatment of Trigeminal Neuralgia |
Terminated |
NCT02088632 |
Phase 2 |
|
26 |
A Phase 1, Open-label Study to Evaluate the Relative Bioavailability of Two Formulations of BIIB074 and to Assess the Effect of Food on BIIB074 Pharmacokinetics in Healthy Subjects |
Completed |
NCT02951221 |
Phase 1 |
BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D |
27 |
A Randomized, Double-blind, Placebo Controlled, Two Period Crossover Study to Investigate the Pharmacokinetics, Tolerability and Cognitive Effects of an Oral Dose Regimen of 150mg Tid CNV1014802 in Healthy Young Versus Elderly Male and Female Subjects |
Completed |
NCT02359344 |
Phase 1 |
CNV1014802;Placebo |
28 |
A Phase 1 Pharmacokinetics and Safety Study of BIIB074 in Healthy Japanese and Caucasian Subjects |
Completed |
NCT02831517 |
Phase 1 |
BIIB074;Placebo |
29 |
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Trigeminal Neuralgia and Peripheral Neuropathy |
Recruiting |
NCT05152368 |
Phase 1 |
|
30 |
Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. |
Terminated |
NCT02321566 |
Phase 1 |
|
31 |
Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache |
Withdrawn |
NCT04353505 |
Phase 1 |
Ketorolac;Dexamethasone |
32 |
An Investigation of Transcranial Magnetic Stimulation (TMS) for Trigeminal Neuralgia (TGN) |
Unknown status |
NCT04120129 |
|
|
33 |
The Clinical Benefits of the Combination Use of Acupuncture and Antihistamine on Trigeminal Neuralgia |
Unknown status |
NCT04384224 |
|
|
34 |
Applied Research on Patients With Trigeminal Neuralgia by Multi-planar Reconstruction, Curved Planar Reconstruction and Magnetic Resonance Virtual Endoscopy |
Unknown status |
NCT02713646 |
|
|
35 |
Brain Activity Assessment by Functional MRI Before, After Radiofrequency of Gasserian Ganglia in Patient With Trigeminal Neuralgia |
Unknown status |
NCT03305289 |
|
|
36 |
An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia |
Unknown status |
NCT02801630 |
|
|
37 |
Transitional Care Services: A Quality and Safety Process Improvement Programme in Neurosurgery |
Unknown status |
NCT03593330 |
|
|
38 |
Symptomatic Trigeminal Neuralgia Attributed to Multiple Sclerosis - Clinical Characteristics, Neuroanatomical Abnormalities and Treatment Efficacy |
Completed |
NCT04371575 |
|
Carbamazepine |
39 |
Pulsed Radiofrequency in Treatment of Classic Trigeminal Neuralgia (Prolonged Duration Versus Higher Voltage) |
Completed |
NCT04355221 |
|
|
40 |
Mapping Towards a Cure - Identification of Neurophysiologic Signatures of Trigeminal Neuralgia Pain |
Completed |
NCT03778177 |
|
|
41 |
Prognosis of Trigeminal Neuralgia When Enrolled in a Multidisciplinary Management Program - a Two-year Prospective Real-life Study |
Completed |
NCT03838393 |
|
|
42 |
The Effect of Intravenous Lidocaine on Trigeminal Neuralgia |
Completed |
NCT01955967 |
|
Lidocaine |
43 |
Phenytoin as Treatment for Acute Exacerbations of Trigeminal Neuralgia - a Prospective Systematic Study of 30 Patients |
Completed |
NCT03712254 |
|
Fosphenytoin |
44 |
Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia |
Completed |
NCT03580317 |
|
|
45 |
The Long-Term Outcome of 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia: A Retrospective Study. |
Completed |
NCT03549013 |
|
|
46 |
Efficacy and Complications of Microvascular Decompression - a Prospective Systematic Study of 115 Trigeminal Neuralgia Patients |
Completed |
NCT04445766 |
|
|
47 |
Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital |
Completed |
NCT03669744 |
|
|
48 |
Classical Trigeminal Neuralgia and Sodium Channel Mutations |
Completed |
NCT03656497 |
|
|
49 |
The Value of Sensory Index in Predicting the Success of Radiofrequency Treatment of Trigeminal Neuralgia: A Retrospective Study |
Completed |
NCT04864964 |
|
|
50 |
A Double-Blind Placebo Controlled Add-on Study to Determine the Efficacy and Safety of Lamictal (Lamotrigine) in Patients With Trigeminal Neuralgia (Tic Doloureux) |
Completed |
NCT00203229 |
|
lamotrigine;Placebo |
Inferred drug relations via
UMLS
71
/
NDF-RT
50
:
Baclofen
Carbamazepine
tizanidine
|
tizanidine hydrochloride
Tocainide
Tocainide Monohydrochloride
|
|