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MCID: TRG002
MIFTS: 60

Trigeminal Neuralgia

Categories: Blood diseases, Neuronal diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Trigeminal Neuralgia

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MalaCards integrated aliases for Trigeminal Neuralgia:

Name: Trigeminal Neuralgia 57 12 76 53 54 59 29 55 43 44 15 73
Tic Douloureux 57 53 54
Trifacial Neuralgia 12
Trifocal Neuralgia 12

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant form


HPO:

32
trigeminal neuralgia:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Oral diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare neurological diseases


External Ids:

OMIM 57 190400
Disease Ontology 12 DOID:12098
ICD10 33 G50.0
ICD9CM 35 350.1
MeSH 44 D014277
SNOMED-CT 68 31681005
Orphanet 59 ORPHA221091
MESH via Orphanet 45 D014277
UMLS via Orphanet 74 C0040997
ICD10 via Orphanet 34 G50.0
MedGen 42 C0040997
UMLS 73 C0040997
Sources

Summaries for Trigeminal Neuralgia

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NINDS : 54 Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary : Trigeminal Neuralgia, also known as tic douloureux, is related to burning mouth syndrome and neuroma, and has symptoms including seizures, tremor and back pain. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are L1CAM interactions and Phase 0 - rapid depolarisation. The drugs Triamcinolone and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related phenotypes are depressivity and neoplasm

NIH Rare Diseases : 53 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theĀ face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.

MedlinePlus : 43 Trigeminal neuralgia (TN) is a type of chronic pain that affects your face. It causes extreme, sudden burning or shock-like pain. It usually affects one side of the face. Any vibration on your face, even from talking, can set it off. The condition may come and go, disappearing for days or even months. But the longer you have it, the less often it goes away. TN usually affects people over 50, especially women. The cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. Tumors and multiple sclerosis can also cause TN, but in some cases the cause is unknown. There is no single test to diagnose TN. It can be hard to diagnose, since many other conditions can cause facial pain. Treatment options include medicines, surgery, and complementary techniques. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Trigeminal neuralgia (TN or TGN) is a chronic pain disorder that affects the trigeminal nerve. There are... more...

Description from OMIM: 190400
Sources

Related Diseases for Trigeminal Neuralgia

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Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 burning mouth syndrome 30.3 TRPV1 SCN9A
2 neuroma 30.1 TRPV1 SCN10A
3 postpartum depression 30.0 SLC6A4 ESR1
4 diabetic neuropathy 29.8 TRPV1 SCN9A
5 migraine with or without aura 1 29.8 TRPV1 SLC6A4 ESR1
6 glossopharyngeal neuralgia 11.8
7 headache 11.6
8 sunct headache 11.6
9 paroxysmal hemicrania 11.6
10 hemifacial atrophy, progressive 11.3
11 epidermoid brain cyst 11.3
12 trigeminal trophic syndrome 11.3
13 hemifacial spasm 10.7
14 multiple sclerosis 10.7
15 arteriovenous malformation 10.5
16 persistent idiopathic facial pain 10.4
17 arachnoid cysts 10.4
18 arteriovenous fistula 10.3
19 depression 10.3
20 epidermoid cysts 10.2
21 hydrocephalus 10.2
22 anxiety 10.2
23 acoustic neuroma 10.2
24 cavernous malformation 10.2
25 sodium channelopathy-related small fiber neuropathy 10.2 SCN9A SCN10A
26 erythermalgia, primary 10.2 SCN9A SCN10A
27 indifference to pain, congenital, autosomal recessive 10.2 SCN9A SCN10A
28 erythromelalgia 10.2 SCN9A SCN10A
29 mononeuritis of lower limb 10.1 TRPV1 SCN10A
30 lesion of sciatic nerve 10.1 TRPV1 SCN10A
31 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
32 sinusitis 10.1
33 lymphoma 10.1
34 squamous cell carcinoma 10.1
35 neurilemmoma 10.1
36 neuropathy 10.1
37 postherpetic neuralgia 10.1
38 charcot-marie-tooth disease and deafness 10.1
39 neuropathy, hereditary motor and sensory, with deafness, mental retardation, and absent sensory large myelinated fibers 10.1
40 hemidystonia 10.1
41 facial neuralgia 10.1
42 tremor 10.1
43 sciatic neuropathy 10.1 TRPV1 SCN10A
44 retinitis pigmentosa 20 10.1 SLC6A4 ESR1
45 somatoform disorder 10.1 TRPV1 SCN9A
46 bone resorption disease 10.1 TRPV1 ESR1
47 dyspepsia 10.1 TRPV1 SLC6A4
48 bone remodeling disease 10.1 TRPV1 ESR1
49 adenomyosis 10.1 TRPV1 ESR1
50 facial spasm 10.0

Comorbidity relations with Trigeminal Neuralgia via Phenotypic Disease Network (PDN):


Acute Cystitis Glossopharyngeal Neuralgia
Hypertension, Essential Hypothyroidism
Multiple Sclerosis

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to Trigeminal Neuralgia
Sources

Symptoms & Phenotypes for Trigeminal Neuralgia

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Symptoms via clinical synopsis from OMIM:

57
Neuro:
trigeminal neuralgia


Clinical features from OMIM:

190400

Human phenotypes related to Trigeminal Neuralgia:

59 32 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 depressivity 59 32 hallmark (90%) Very frequent (99-80%) HP:0000716
2 neoplasm 59 32 occasional (7.5%) Occasional (29-5%) HP:0002664
3 feeding difficulties 59 32 frequent (33%) Frequent (79-30%) HP:0011968
4 paresthesia 59 32 frequent (33%) Frequent (79-30%) HP:0003401
5 peripheral demyelination 59 32 occasional (7.5%) Occasional (29-5%) HP:0011096
6 sensory impairment 59 32 frequent (33%) Frequent (79-30%) HP:0003474
7 ocular pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0200026
8 trigeminal neuralgia 59 32 obligate (100%) Obligate (100%) HP:0100661
9 poor speech 59 32 frequent (33%) Frequent (79-30%) HP:0002465
10 cluster headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0012199
11 difficulty in tongue movements 59 32 frequent (33%) Frequent (79-30%) HP:0000183
12 allodynia 59 32 hallmark (90%) Very frequent (99-80%) HP:0012533
13 cranial nerve compression 59 32 occasional (7.5%) Occasional (29-5%) HP:0001293
14 episodic paroxysmal anxiety 59 32 frequent (33%) Frequent (79-30%) HP:0000740
15 vascular tortuosity 59 32 frequent (33%) Frequent (79-30%) HP:0004948
16 mandibular pain 59 32 frequent (33%) Frequent (79-30%) HP:0200025
17 cns demyelination 59 32 occasional (7.5%) Occasional (29-5%) HP:0007305
18 abnormality of the nervous system 32 HP:0000707

UMLS symptoms related to Trigeminal Neuralgia:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, facial pain, vertigo/dizziness, sleeplessness, neuralgia, atypical facial pain, orofacial pain

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 CRLF1 ESR1 MBD1 SCN10A SCN3A SCN9A
2 nervous system MP:0003631 9.17 CRLF1 ESR1 MBD1 SCN10A SCN9A SLC6A4
Sources

Drugs & Therapeutics for Trigeminal Neuralgia

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Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
3
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Not Applicable 1177-87-3
5
Artemether Approved Phase 4 71963-77-4 119380 68911
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
7
Lumefantrine Approved Phase 4 82186-77-4 6437380
8
Acetylcholine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-84-3 187
9
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 298-46-4 2554
10
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
11
Ondansetron Approved Phase 4 99614-02-5 4595
12
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
13
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
14
Oxcarbazepine Approved Phase 4 28721-07-5 34312
15 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
16
protease inhibitors Phase 4
17 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
19 Hormone Antagonists Phase 4
20 Immunosuppressive Agents Phase 4
21 Anesthetics, Local Phase 4,Phase 2,Phase 3,Not Applicable
22 Triamcinolone diacetate Phase 4
23 Antineoplastic Agents, Hormonal Phase 4
24 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
25 glucocorticoids Phase 4
26 Hormones Phase 4
27 Autonomic Agents Phase 4
28 HIV Protease Inhibitors Phase 4
29 Immunologic Factors Phase 4
30 BB 1101 Phase 4,Not Applicable
31 Anti-Inflammatory Agents Phase 4
32 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Antiemetics Phase 4
34 Gastrointestinal Agents Phase 4
35 Triamcinolone hexacetonide Phase 4
36 triamcinolone acetonide Phase 4
37 Anthelmintics Phase 4
38 Artemisinins Phase 4
39 Antiparasitic Agents Phase 4
40 Artemether-lumefantrine combination Phase 4
41 Anti-Infective Agents Phase 4,Not Applicable
42 Antifungal Agents Phase 4,Not Applicable
43 Artemisinine Phase 4
44 Antimalarials Phase 4
45 Antiprotozoal Agents Phase 4
46 Acetylcholine Release Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
47 Cholinergic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
48 onabotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
49 abobotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
50 Neuromuscular Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
2 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed NCT02024724 Phase 4 Bupivacaine;Triamcinolone;Dexamethasone
3 A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) Completed NCT01256658 Phase 4 COA566
4 (Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist Recruiting NCT03381261 Phase 4 Botulinum toxin type A
5 Postoperative Analgesia in Patients With Microvascular Decompression Active, not recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
6 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
7 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
8 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3 Levobupivacaine;Bupivacaine
9 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
10 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
11 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
12 Botulinum Toxin Injections for Oral Neuropathic Pain Not yet recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
13 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
14 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
15 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
16 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
17 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
18 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
19 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
20 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
21 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Recruiting NCT02624661 Phase 1, Phase 2 Glycerol
22 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
23 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
24 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
25 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
26 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
27 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
28 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630 Not Applicable
29 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
30 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
31 Classical Trigeminal Neuralgia and Sodium Channel Mutations Completed NCT03656497
32 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia Completed NCT03549013
33 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406 Not Applicable
34 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Completed NCT01761604 Not Applicable
35 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 Not Applicable lamotrigine;Placebo
36 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 Not Applicable L-baclofen
37 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Not Applicable Lidocaine
38 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807 Not Applicable
39 Hippocampal Radiation Exposure and Memory Completed NCT00603694
40 A Study of Intra-dermal Injection of Botulinum Toxin Type A for the Diabetic Neuropathic Foot Pain Completed NCT00336349 Not Applicable Botulinum Toxin Type A
41 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
42 Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital Recruiting NCT03669744
43 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810 Not Applicable
44 High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia Recruiting NCT03131466 Not Applicable Nerve block
45 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323
46 An Follow-up Study of Occlusal Adjustment for Orofacial Pain Recruiting NCT02856906 Not Applicable
47 Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy Recruiting NCT01632657 Not Applicable Sumatriptan;Placebo
48 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
49 Neurosurgical Transitional Care Programme Recruiting NCT03593330 Not Applicable
50 Comparison Between Radiofrequency and Balloon Compression in the Treatment of Idiopathic Trigeminal Neuralgia Active, not recruiting NCT02427074 Not Applicable

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: trigeminal neuralgia

Sources

Genetic Tests for Trigeminal Neuralgia

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Genetic tests related to Trigeminal Neuralgia:

# Genetic test Affiliating Genes
1 Trigeminal Neuralgia 29
Sources

Anatomical Context for Trigeminal Neuralgia

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MalaCards organs/tissues related to Trigeminal Neuralgia:

41
Brain, Testes, Skin, Trigeminal Ganglion, Tongue, Cortex, Bone
Sources

Publications for Trigeminal Neuralgia

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Articles related to Trigeminal Neuralgia:

(show top 50) (show all 1612)
# Title Authors Year
1
Trigeminal Neuralgia due to Vertebrobasilar Artery Compression. ( 29959080 )
2018
2
The timing of stereotactic radiosurgery for medically refractory trigeminal neuralgia: the evidence from diffusion tractography images. ( 29397449 )
2018
3
Therapeutic failure in trigeminal neuralgia: from a clarification of trigeminal nerve somatotopy to a targeted partial sensory rhizotomy. ( 29883821 )
2018
4
Pain-Free outcomes and Durability of Surgical Intervention for Trigeminal Neuralgia: A Comparison of Gamma Knife and Microvascular Decompression. ( 29382615 )
2018
5
Management of Primary Bilateral Trigeminal Neuralgia with Microvascular Decompression: 13-Case Series. ( 29066316 )
2018
6
Quantitative analysis of the safety and efficacy of microvascular decompression for patients with trigeminal neuralgia above and below 65a8^years of age. ( 29954647 )
2018
7
Extensive Craniocervical Abscess after Transoral Ganglionic Local Opioid Analgesia at the Superior Cervical Ganglion for Atypical Trigeminal Neuralgia: Report of a Severely Complicated Case. ( 29977303 )
2018
8
Dosimetric comparison of sector-blocked and non-sector-blocked Gamma Knife Perfexion treatment plans for trigeminal neuralgia. ( 29395459 )
2018
9
Surgical Management of Familial Trigeminal Neuralgia With Different Inheritance Patterns: A Case Report. ( 29867726 )
2018
10
Altered structure and functional connection in patients with classical trigeminal neuralgia. ( 29105886 )
2018
11
Intra- and postoperative bleeding in microvascular decompression for trigeminal neuralgia. ( 29959070 )
2018
12
Letter to the Editor. Cafeteria approach to management of trigeminal neuralgia: stereotactic radiosurgery as a preferred option. ( 29957108 )
2018
13
Immediate and Long-term Outcomes of Microvascular Decompression for Mixed Trigeminal Neuralgia. ( 29906578 )
2018
14
Trigeminal Neuralgia Secondary to Osteoid Osteoma of the Petrous Bone: Report of 4 Cases and Brief Review of Literature. ( 29551722 )
2018
15
Bridging veins and veins of the brainstem in microvascular decompression surgery for trigeminal neuralgia and hemifacial spasm. ( 29961378 )
2018
16
Prognostic factors for outcome of microvascular decompression in trigeminal neuralgia: A prospective systematic study using independent assessors. ( 29896973 )
2018
17
Awake Microvascular Decompression for Trigeminal Neuralgia: Concept and Initial Results. ( 29452326 )
2018
18
Trigeminal Nerve Compression Without Trigeminal Neuralgia: Intraoperative vs Imaging Evidence. ( 29425330 )
2018
19
Multivariate Pattern Classification of Brain White Matter Connectivity Predicts Classic Trigeminal Neuralgia. ( 29905649 )
2018
20
Computed tomography-guided percutaneous ozone injection of the Gasserian ganglion for the treatment of trigeminal neuralgia. ( 29430195 )
2018
21
Cystic Progression of a Cavernous Malformation at the Level of the Trigeminal Root Entry Zone Presenting With Sudden Onset of Trigeminal Neuralgia. ( 29570519 )
2018
22
Early Stereotactic Radiosurgery for Medically Refractory Trigeminal Neuralgia. ( 29371169 )
2018
23
Editors' note: Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. ( 29378922 )
2018
24
Validation of MLC-based linac radiosurgery for trigeminal neuralgia. ( 29901278 )
2018
25
Measuring the impact of trigeminal neuralgia pain: the Penn Facial Pain Scale-Revised. ( 29892203 )
2018
26
Successive occurrence of vertebrobasilar dolichectasia induced trigeminal neuralgia, vestibular paroxysmia and hemifacial spasm: A case report. ( 29924039 )
2018
27
Trigeminal Neuralgia in Pregnancy: A Management Challenge. ( 28574640 )
2018
28
Reader response: Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. ( 29378923 )
2018
29
Preoperative evaluation of neurovascular relationship in trigeminal neuralgia by three-dimensional fast low angle shot (3D-FLASH) and three-dimensional constructive interference in steady-state (3D-CISS) MRI sequence. ( 29388798 )
2018
30
Effect of coenzyme Q10 on mitochondrial respiratory proteins in trigeminal neuralgia. ( 29424256 )
2018
31
Abnormal brain white matter in patients with right trigeminal neuralgia: a diffusion tensor imaging study. ( 29931400 )
2018
32
Characterizing Treatment Utilization Patterns for Trigeminal Neuralgia in the United States. ( 29443722 )
2018
33
Author response: Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. ( 29378924 )
2018
34
Long-term follow-up of multimodality treatment for multiple sclerosis-related trigeminal neuralgia. ( 29167978 )
2018
35
Curcumin alleviates pain and improves cognitive impairment in a rat model of cobra venom-induced trigeminal neuralgia. ( 29950886 )
2018
36
Diffusion Tensor Imaging of Axonal and Myelin Changes in Classical Trigeminal Neuralgia. ( 29410338 )
2018
37
Therapeutic and Analgesic Efficacy of Laser in Conjunction With Pharmaceutical Therapy for Trigeminal Neuralgia. ( 29399314 )
2018
38
Sixth cranial nerve palsy and ipsilateral trigeminal neuralgia caused by vertebrobasilar dolichoectasia. ( 29780939 )
2018
39
Assessment of efficacy and safety of eslicarbazepine acetate for the treatment of trigeminal neuralgia. ( 29369456 )
2018
40
Trigeminal Neuralgia Caused by Dural Arteriovenous Fistula in Meckel Cave Treated with Gamma Knife Radiosurgery: A Case Report. ( 30500585 )
2018
41
Recurrent secondary trigeminal neuralgia caused by an obliterated tentorial dural arteriovenous fistula cured with surgical resection: A case report and literature review. ( 30176399 )
2018
42
Diffuse Large B Cell Lymphoma presented as trigeminal neuralgia: two cases reported and literatures review. ( 30528527 )
2018
43
Clinical spectrum of associated SUNCT (shortlasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) and trigeminal neuralgia: a multidisciplinary approach in the emergency department. ( 29687680 )
2018
44
The Exacerbation of Hemicrania Continua Mimics Trigeminal Neuralgia. ( 30333409 )
2018
45
Multimodal Image-Based Virtual Reality Presurgical Simulation and Evaluation for Trigeminal Neuralgia and Hemifacial Spasm. ( 29476993 )
2018
46
Hemodynamic features of offending vessels at neurovascular contact in patients with trigeminal neuralgia and hemifacial spasm. ( 29979116 )
2018
47
Surgical management of coexisting trigeminal neuralgia and hemifacial spasm. ( 30488012 )
2018
48
Unique case of trigeminal neuralgia due to Epstein-Barr-virus-associated B-cell lymphomatoid granulomatosis of the Meckel's cave and cavernous sinus: Important clinical and therapeutic implications. ( 30105142 )
2018
49
Radiosurgery for multiple sclerosis-related trigeminal neuralgia: retrospective review of long-term outcomes. ( 30544359 )
2018
50
Letter to the Editor. Microsurgical rhizotomy as treatment for trigeminal neuralgia in patients with multiple sclerosis: turnpike or dirt road? ( 30485220 )
2018
Sources

Variations for Trigeminal Neuralgia

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Expression for Trigeminal Neuralgia

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Search GEO for disease gene expression data for Trigeminal Neuralgia.
Sources

Pathways for Trigeminal Neuralgia

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Pathways related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
L1CAM interactions 66
Show member pathways
 11.43 SCN10A SCN3A SCN9A
2
Phase 0 - rapid depolarisation 66
Show member pathways
 11.01 SCN10A SCN3A SCN9A
3
Interaction between L1 and Ankyrins 66
10.28 SCN10A SCN3A SCN9A
Sources

GO Terms for Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of presynaptic membrane GO:0099056 8.96 SCN10A SLC6A4
2 voltage-gated sodium channel complex GO:0001518 8.8 SCN10A SCN3A SCN9A

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.78 SCN10A SCN3A SCN9A TRPV1
2 ion transmembrane transport GO:0034220 9.67 SCN10A SCN3A SCN9A TRPV1
3 transmembrane transport GO:0055085 9.65 SCN10A SCN3A SCN9A SLC6A4 TRPV1
4 regulation of ion transmembrane transport GO:0034765 9.63 SCN10A SCN3A SCN9A
5 sodium ion transport GO:0006814 9.61 SCN10A SCN3A SCN9A
6 sodium ion transmembrane transport GO:0035725 9.5 SCN10A SCN3A SCN9A
7 behavioral response to pain GO:0048266 9.4 SCN9A TRPV1
8 sensory perception of pain GO:0019233 9.33 SCN10A SCN9A TRPV1
9 neuronal action potential GO:0019228 9.13 SCN10A SCN3A SCN9A
10 membrane depolarization during action potential GO:0086010 8.8 SCN10A SCN3A SCN9A

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.46 SCN10A SCN3A SCN9A TRPV1
2 voltage-gated ion channel activity GO:0005244 9.43 SCN10A SCN3A SCN9A
3 sodium channel activity GO:0005272 9.13 SCN10A SCN3A SCN9A
4 voltage-gated sodium channel activity GO:0005248 8.8 SCN10A SCN3A SCN9A
Sources

Sources for Trigeminal Neuralgia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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