Trigeminal Neuralgia

Categories: Neuronal diseases, Rare diseases
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Aliases & Classifications for Trigeminal Neuralgia

MalaCards integrated aliases for Trigeminal Neuralgia:

Name: Trigeminal Neuralgia 57 11 19 52 58 75 28 53 41 43 14 16 71 31 33
Tic Douloureux 57 19 33
Neuralgia of the Fifth Cranial Nerve 33
Neuralgia of 5th Cranial Nerve 33
Infraorbital Neuralgia 33
Trifacial Neuralgia 11
Trifocal Neuralgia 11



Autosomal dominant form 57


1-9/100000 (United States, United Kingdom) 58

Age Of Onset:

Adolescent,Adult,Elderly 58


Orphanet: 58  
Rare neurological diseases

External Ids:

Disease Ontology 11 DOID:12098
OMIM® 57 190400
ICD9CM 34 350.1
MeSH 43 D014277
SNOMED-CT 68 155066002
ICD10 31 G50.0
MESH via Orphanet 44 D014277
ICD10 via Orphanet 32 G50.0
UMLS via Orphanet 72 C0040997
Orphanet 58 ORPHA221091
MedGen 40 C0040997
ICD11 33 1803581281
UMLS 71 C0040997

Summaries for Trigeminal Neuralgia

NINDS: 52 Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary: Trigeminal Neuralgia, also known as tic douloureux, is related to headache and glossopharyngeal neuralgia, and has symptoms including tremor, back pain and headache. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and CREB Pathway. The drugs Ropivacaine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include trigeminal ganglion, brain and skin, and related phenotypes are trigeminal neuralgia and depression

MedlinePlus: 41 Trigeminal neuralgia (TN) is a type of chronic pain that affects your face. It causes extreme, sudden burning or shock-like pain. It usually affects one side of the face. Any vibration on your face, even from talking, can set it off. The condition may come and go, disappearing for days or even months. But the longer you have it, the less often it goes away. TN usually affects people over 50, especially women. The cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. Tumors and multiple sclerosis can also cause TN, but in some cases the cause is unknown. There is no specific test for TN. It can be hard to diagnose, since many other conditions can cause facial pain. Treatment options include medicines, surgery, and complementary techniques. NIH: National Institute of Neurological Disorders and Stroke

GARD: 19 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown.

Orphanet: 58 A rare acquired peripheral neuropathy characterized by paroxysmal, sharp, stabbing, electric-shock-like orofacial pain, that is restricted to one or more of the trigeminal nerve divisions and mostly unilateral. Attacks are brief (few seconds to a maximum of two minutes), but typically occur repeatedly and periodically, can arise spontaneously or be triggered by innocuous stimuli, and are frequently accompanied by tic-like cramps of facial muscles. The condition affects women more often than men.

Wikipedia: 75 Trigeminal neuralgia (TN or TGN), also called Fothergill disease, tic douloureux, or trifacial neuralgia... more...

More information from OMIM: 190400

Related Diseases for Trigeminal Neuralgia

Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 609)
# Related Disease Score Top Affiliating Genes
1 headache 31.7 SLC6A4 LOC110806262 COMT CALCA CACNA1A BDNF
2 glossopharyngeal neuralgia 31.5 TRPV1 TAC1 SCN9A P2RX3 KANTR CALCA
3 cluster headache 31.2 CALCA CACNA1A
4 chronic pain 31.1 SCN9A P2RX3 COMT BDNF
5 neuropathy 30.9 SCN9A SCN11A SCN10A NTRK1
6 neuroma 30.8 TRPV1 SCN10A CALCA
7 lateral medullary syndrome 30.6 TAC1 CALCA
8 hereditary sensory neuropathy 30.5 SCN9A SCN11A NTRK1 BDNF
9 sleep disorder 30.5 TAC1 SLC6A4 COMT BDNF
10 hemidystonia 30.5 GCH1 CACNA1A
11 choreatic disease 30.4 TAC1 CACNA1A BDNF
12 major depressive disorder 30.3 TAC1 SLC6A4 ESR1 COMT BDNF
13 bipolar disorder 30.3 SLC6A4 GCH1 ESR1 COMT BDNF
14 anxiety 30.3 TRPV1 TAC1 SLC6A4 ESR1 COMT BDNF
15 migraine without aura 30.3 SLC6A4 ESR1 CACNA1A
16 bipolar i disorder 30.2 SLC6A4 COMT BDNF
17 postpartum depression 30.2 SLC6A4 COMT BDNF
18 hyperhidrosis, gustatory 30.2 TRPV1 TAC1 KANTR
19 post-traumatic stress disorder 30.2 SLC6A4 COMT BDNF
20 plantar fasciitis 30.1 TAC1 CALCA
22 movement disease 30.0 GCH1 COMT CACNA1A BDNF
23 vasomotor rhinitis 30.0 TRPV1 TAC1 CALCA
24 nerve compression syndrome 30.0 TRPV1 TAC1 CALCA
25 sensory peripheral neuropathy 29.9 TRPV1 TAC1 SCN11A NTRK1 BDNF
26 alcohol dependence 29.9 SLC6A4 LOC110806262 COMT BDNF
27 diarrhea 29.9 TRPV1 TAC1 SLC6A4 CALCA BDNF
28 myofascial pain syndrome 29.9 TRPV1 TAC1 P2RX3 CALCA BDNF
29 paine syndrome 29.9 TRPV1 TAC1 SLC6A4 SCN9A SCN8A SCN3A
30 reflex sympathetic dystrophy 29.8 TRPV1 TAC1 SCN9A SCN11A CALCA
31 bursitis 29.7 TAC1 CALCA
32 causalgia 29.7 TRPV1 TAC1 SCN9A SCN10A CALCA
33 fibromyalgia 29.7 SLC6A4 SCN9A P2RX3 COMT CALCA BDNF
34 oromandibular dystonia 29.6 KANTR GCH1
35 burning mouth syndrome 29.6 TRPV1 TAC1 SLC6A4 SCN9A P2RX3 CALCA
36 pain agnosia 29.5 TRPV1 TAC1 SCN9A SCN11A SCN10A P2RX3
37 migraine with aura 29.5 TAC1 SLC6A4 SCN9A LOC110806262 ESR1 CALCA
38 diabetic neuropathy 29.2 TRPV1 TAC1 SCN9A SCN11A SCN10A NTRK1
39 complex regional pain syndrome 29.2 TRPV1 TAC1 SCN9A SCN11A SCN10A P2RX3
40 erythromelalgia 29.1 TRPV1 TAC1 SCN9A SCN8A SCN3A SCN11A
41 nervous system disease 29.0 TRPV1 TAC1 SLC6A4 SCN9A SCN8A NTRK1
42 migraine with or without aura 1 28.9 TRPV1 TAC1 SLC6A4 SCN9A SCN8A SCN3A
43 peripheral nervous system disease 28.7 TRPV1 TAC1 SCN9A SCN8A SCN3A SCN11A
44 sunct headache 11.3
45 hemifacial atrophy, progressive 11.2
46 combined hyperactive dysfunction syndrome of the cranial nerves 11.2
47 hemifacial spasm 10.9
48 multiple sclerosis 10.8
49 meningioma, familial 10.8
50 persistent idiopathic facial pain 10.8

Comorbidity relations with Trigeminal Neuralgia via Phenotypic Disease Network (PDN):

Acute Cystitis Glossopharyngeal Neuralgia
Hypertension, Essential Hypothyroidism
Multiple Sclerosis

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:

Diseases related to Trigeminal Neuralgia

Symptoms & Phenotypes for Trigeminal Neuralgia

Human phenotypes related to Trigeminal Neuralgia:

58 30 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 trigeminal neuralgia 58 30 Obligate (100%) Obligate (100%)
2 depression 58 30 Hallmark (90%) Very frequent (99-80%)
3 allodynia 58 30 Hallmark (90%) Very frequent (99-80%)
4 cluster headache 58 30 Hallmark (90%) Very frequent (99-80%)
5 paresthesia 58 30 Frequent (33%) Frequent (79-30%)
6 feeding difficulties 58 30 Frequent (33%) Frequent (79-30%)
7 poor speech 58 30 Frequent (33%) Frequent (79-30%)
8 mandibular pain 58 30 Frequent (33%) Frequent (79-30%)
9 episodic paroxysmal anxiety 58 30 Frequent (33%) Frequent (79-30%)
10 difficulty in tongue movements 58 30 Frequent (33%) Frequent (79-30%)
11 vascular tortuosity 58 30 Frequent (33%) Frequent (79-30%)
12 neoplasm 58 30 Occasional (7.5%) Occasional (29-5%)
13 ocular pain 58 30 Occasional (7.5%) Occasional (29-5%)
14 peripheral demyelination 58 30 Occasional (7.5%) Occasional (29-5%)
15 cns demyelination 58 30 Occasional (7.5%) Occasional (29-5%)
16 cranial nerve compression 58 30 Occasional (7.5%) Occasional (29-5%)
17 sensory impairment 58 Frequent (79-30%)

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
trigeminal neuralgia

Clinical features from OMIM®:

190400 (Updated 08-Dec-2022)

UMLS symptoms related to Trigeminal Neuralgia:

tremor; back pain; headache; syncope; pain; chronic pain; sciatica; seizures; vertigo/dizziness; sleeplessness; neuralgia; facial pain; atypical facial pain; orofacial pain

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.27 BDNF CACNA1A CACNA1H CALCA COMT ESR1
2 normal MP:0002873 10.13 BDNF CACNA1A CALCA ESR1 NTRK1 SCN3A
3 growth/size/body region MP:0005378 10.13 BDNF CACNA1A CACNA1H ESR1 GCH1 NTRK1
4 behavior/neurological MP:0005386 10.13 BDNF CACNA1A CACNA1H CALCA COMT ESR1
5 no phenotypic analysis MP:0003012 10.01 BDNF CACNA1A ESR1 KANTR NTRK1 SCN10A
6 cardiovascular system MP:0005385 10 CACNA1H CALCA COMT ESR1 GCH1 P2RX3
7 respiratory system MP:0005388 9.56 BDNF CACNA1A CACNA1H CALCA ESR1 P2RX3
8 integument MP:0010771 9.44 BDNF CACNA1A CALCA ESR1 NTRK1 P2RX3

Drugs & Therapeutics for Trigeminal Neuralgia

Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
Ondansetron Approved, Withdrawn Phase 4 99614-02-5 4595
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Zileuton Approved, Investigational, Withdrawn Phase 4 111406-87-2 60490
8 Analgesics Phase 4
9 Neurotransmitter Agents Phase 4
10 Antipsychotic Agents Phase 4
11 Antiemetics Phase 4
12 Gastrointestinal Agents Phase 4
13 Analgesics, Opioid Phase 4
14 Excitatory Amino Acid Antagonists Phase 4
15 Narcotics Phase 4
16 Dsuvia Phase 4
17 Anti-Anxiety Agents Phase 4
18 Anesthetics, Intravenous Phase 4
19 Anesthetics, General Phase 4
20 Anesthetics, Dissociative Phase 4
21 Psychotropic Drugs Phase 4
22 Anti-Arrhythmia Agents Phase 4
23 Anesthetics, Local Phase 4
24 Anesthetics Phase 4
25 Leukotriene Antagonists Phase 4
26 Immunoglobulins Phase 4
27 Antibodies, Blocking Phase 4
28 Antibodies Phase 4
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
Lamotrigine Approved, Investigational Phase 2, Phase 3 84057-84-1 3878
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
32 Antipain Experimental Phase 2, Phase 3 37691-11-5
33 Calcium, Dietary Phase 2, Phase 3
34 calcium channel blockers Phase 2, Phase 3
35 Protective Agents Phase 3
36 Radiation-Protective Agents Phase 3
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
Erenumab Approved, Investigational Phase 2 1582205-90-0
Salmon calcitonin Approved, Investigational Phase 2 47931-85-1 155817456
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 2 14838-15-4, 492-39-7 131954576 4786 26934
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
Dextromethorphan Approved Phase 2 125-71-3 5362449 5360696
Topiramate Approved Phase 2 97240-79-4 5284627
Guanfacine Approved, Investigational Phase 2 29110-47-2 3519
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
Glycerin Approved, Investigational Phase 1, Phase 2 56-81-5 753
Calcitonin gene-related peptide Investigational Phase 2 83652-28-2 91976570
Calcitonin Phase 2
49 Katacalcin Phase 2 16172926
50 Chlorpheniramine, phenylpropanolamine drug combination Phase 2

Interventional clinical trials:

(show top 50) (show all 85)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
2 Examining the Efficacy of Low Intensity Low Frequency Surface Acoustic Wave Ultrasound(LILF/SAWU) in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
3 The PATCH Trial: Effectiveness and Safety of 5% Lidocaine-medicated Plaster for the Treatment of Trigeminal Neuralgia Recruiting NCT04570293 Phase 4 5% lidocaine medicated plaster;vehicle plaster
4 Comparative Efficacy of Carbamazepine Versus Oxcarbazepine in Treatment of Trigeminal Neuralgia- a Randomized Controlled Clinical Study Recruiting NCT04996199 Phase 4 Oxcarbazepine;Carbamazepine
5 Anti-CGRP Neutralizing Antibody for Modulation of Neurogenic Inflammation in Trigeminal and Glossopharyngeal Pain Associated With Small Fiber Neuropathy/Fibromyalgia Active, not recruiting NCT04158752 Phase 4 Galcanezumab
6 Pilot Study of Oxtellar XR (Oxcarbazepine Extended Release) in Neurology Patients With Trigeminal Neuralgia Withdrawn NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
7 The Efficacy and Safety of Botulinum Toxin for the Treatment of Trigeminal Neuralgia: Comparison of Two Different Treatment Methods Unknown status NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
8 Lamotrigine in Trigeminal Neuralgia: Efficacy and Safety in Comparison With Carbamazepine Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
9 A Phase II/III, Multicentre, 8-week run-in Phase Followed by a 12-week, Prospective, Parallel-group, Double-blind, Randomized Withdrawal, Placebo-controlled Study, With a 52 Week Open Label Extension, to Evaluate the Efficacy and Safety of Daily 1.5 to 3.5 mg Basimglurant in Patients With Pain Associated With Trigeminal Neuralgia With Suboptimal Response to Their Current Anti-pain Therapy. Recruiting NCT05217628 Phase 2, Phase 3 Basimglurant
10 A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
11 A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
12 A Randomized, Placebo-controlled Trial of Amifostine for Prevention of Facial Numbness in Patients Receiving Stereotactic Radiosurgery for Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
13 Phase II Double Blind, Randomized, Placebo Controlled, Safety and Efficacy Study of ATNC05 in Patients With Atypical Facial Pain With an Open-Label Extension Phase for Nonresponders Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
14 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
15 A Prospective Study on Efficacy of Hyperbaric Oxygenation Treatment for Patients With Trigeminal Neuralgia: a Randomized, Double-Blind, Mock Hyperbaric Chamber -Controlled, Parallel-Group Trial Unknown status NCT00866424 Phase 1, Phase 2
16 A Placebo-Controlled, Double-Blind, Randomized, Proof-of-Concept Study to Evaluate the Efficacy and Tolerability of Erenumab in Patients With Trigeminal Neuralgia Unknown status NCT04054024 Phase 2 Erenumab;Placebos
17 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
18 A Placebo-Controlled, Single-Blind Study Evaluating the Safety and Efficacy of Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
19 A Phase IIa Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Safety and Efficacy of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
20 Clinical Trials in Orofacial Neuralgias Completed NCT00001725 Phase 2 Dextromethorphan
21 Paresthesia-free Peripheral Nerve Field Stimulation for Trigeminal Neuralgia: a Double-blinded, Randomized Trial (FreeST Trial) Recruiting NCT05615714 Phase 1, Phase 2
22 A Randomized, Double-Blind, 2-Way Crossover Trial to Assess the Efficacy of Guanfacine and Lidocaine Combination Versus Lidocaine Alone in Trigeminal Nerve Block for Pain Management in Painful Trigeminal Neuropathy Patients Recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
23 BHV3000-202: Phase 2: A Double-Blind, Placebo Controlled, Crossover Trial of BHV-3000 (Rimegepant) for Treatment Refractory Trigeminal Neuraligia Recruiting NCT03941834 Phase 2 Rimegepant;Placebo
24 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Terminated NCT02624661 Phase 1, Phase 2 Glycerol
25 A Randomized, Double-Blind, Placebo-Controlled, Add-on Therapy Study of Xeomin (Incobotulinumtoxina) Versus Placebo in the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
26 A Phase 1, Open-label Study to Evaluate the Relative Bioavailability of Two Formulations of BIIB074 and to Assess the Effect of Food on BIIB074 Pharmacokinetics in Healthy Subjects Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
27 A Randomized, Double-blind, Placebo Controlled, Two Period Crossover Study to Investigate the Pharmacokinetics, Tolerability and Cognitive Effects of an Oral Dose Regimen of 150mg Tid CNV1014802 in Healthy Young Versus Elderly Male and Female Subjects Completed NCT02359344 Phase 1 CNV1014802;Placebo
28 A Phase 1 Pharmacokinetics and Safety Study of BIIB074 in Healthy Japanese and Caucasian Subjects Completed NCT02831517 Phase 1 BIIB074;Placebo
29 Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Trigeminal Neuralgia and Peripheral Neuropathy Recruiting NCT05152368 Phase 1
30 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
31 Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache Withdrawn NCT04353505 Phase 1 Ketorolac;Dexamethasone
32 An Investigation of Transcranial Magnetic Stimulation (TMS) for Trigeminal Neuralgia (TGN) Unknown status NCT04120129
33 The Clinical Benefits of the Combination Use of Acupuncture and Antihistamine on Trigeminal Neuralgia Unknown status NCT04384224
34 Applied Research on Patients With Trigeminal Neuralgia by Multi-planar Reconstruction, Curved Planar Reconstruction and Magnetic Resonance Virtual Endoscopy Unknown status NCT02713646
35 Brain Activity Assessment by Functional MRI Before, After Radiofrequency of Gasserian Ganglia in Patient With Trigeminal Neuralgia Unknown status NCT03305289
36 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630
37 Transitional Care Services: A Quality and Safety Process Improvement Programme in Neurosurgery Unknown status NCT03593330
38 Symptomatic Trigeminal Neuralgia Attributed to Multiple Sclerosis - Clinical Characteristics, Neuroanatomical Abnormalities and Treatment Efficacy Completed NCT04371575 Carbamazepine
39 Pulsed Radiofrequency in Treatment of Classic Trigeminal Neuralgia (Prolonged Duration Versus Higher Voltage) Completed NCT04355221
40 Mapping Towards a Cure - Identification of Neurophysiologic Signatures of Trigeminal Neuralgia Pain Completed NCT03778177
41 Prognosis of Trigeminal Neuralgia When Enrolled in a Multidisciplinary Management Program - a Two-year Prospective Real-life Study Completed NCT03838393
42 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Lidocaine
43 Phenytoin as Treatment for Acute Exacerbations of Trigeminal Neuralgia - a Prospective Systematic Study of 30 Patients Completed NCT03712254 Fosphenytoin
44 Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia Completed NCT03580317
45 The Long-Term Outcome of 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia: A Retrospective Study. Completed NCT03549013
46 Efficacy and Complications of Microvascular Decompression - a Prospective Systematic Study of 115 Trigeminal Neuralgia Patients Completed NCT04445766
47 Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital Completed NCT03669744
48 Classical Trigeminal Neuralgia and Sodium Channel Mutations Completed NCT03656497
49 The Value of Sensory Index in Predicting the Success of Radiofrequency Treatment of Trigeminal Neuralgia: A Retrospective Study Completed NCT04864964
50 A Double-Blind Placebo Controlled Add-on Study to Determine the Efficacy and Safety of Lamictal (Lamotrigine) in Patients With Trigeminal Neuralgia (Tic Doloureux) Completed NCT00203229 lamotrigine;Placebo

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS 71 / NDF-RT 50 :

tizanidine hydrochloride
Tocainide Monohydrochloride

Cochrane evidence based reviews: trigeminal neuralgia

Genetic Tests for Trigeminal Neuralgia

Genetic tests related to Trigeminal Neuralgia:

# Genetic test Affiliating Genes
1 Trigeminal Neuralgia 28

Anatomical Context for Trigeminal Neuralgia

Organs/tissues related to Trigeminal Neuralgia:

MalaCards : Trigeminal Ganglion, Brain, Skin, Tongue, Cortex, Whole Blood, Dorsal Root Ganglion

Publications for Trigeminal Neuralgia

Articles related to Trigeminal Neuralgia:

(show top 50) (show all 7108)
# Title Authors PMID Year
Familial trigeminal neuralgia: case report. 62 57
2716987 1989
Familial trigeminal neuralgia. 62 57
7387447 1980
Inherited tic douloureux. 62 57
4737685 1973
14315671 1965
[Trigeminal neuralgia in three brothers of which two were twins]. 62 57
13794177 1959
Trigeminal ganglion itself can be a viable target to manage trigeminal neuralgia. 62 41
36424545 2022
Morphometric examination of trigeminal nerve and its adjacent structures in patients with trigeminal neuralgia: a case-control study. 62 41
36422504 2022
A Combination of 3D TOF MRA and FIESTA Predicts Surgery-Needed Primary Trigeminal Neuralgia and Specific Offending Vessels. 62 41
36424742 2022
17856710 1936
Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. 53 62
11642720 2001
Transcriptional mRNA of bone morphogenetic proteins 2, 3, 4, and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. 53 62
11411255 2001
Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor regulate the interaction between astrocytes and Schwann cells at the trigeminal root entry zone. 62
36453424 2023
Trigeminal Neuralgia: Diagnosis and Treatment. 62
36400550 2023
Trigeminal Neuralgia. 62
36404084 2023
Trigeminal neuralgia following Tolosa-Hunt syndrome. 62
33826103 2022
Increased cerebrospinal fluid S100B protein levels in patients with trigeminal neuralgia and hemifacial spasm. 62
36459237 2022
Microglia activation and temporal changes in rat model of trigeminal neuralgia. 62
36416315 2022
How I do it: re-do surgery for recurrent trigeminal neuralgia. 62
36329317 2022
Percutaneous Balloon Compression for Treatment of Trigeminal Neuralgia Assisted by O-Arm O2-Based Navigation: Case Series and Review of the Literature. 62
36227191 2022
Trigeminal neuralgia as a complication after anterior temporal lobectomy: A case report. 62
35609669 2022
Long-term results of upfront, single-session Gamma Knife radiosurgery for large cystic vestibular schwannomas. 62
36471101 2022
Long-term outcomes and predictors of percutaneous radiofrequency thermocoagulation of Gasserian ganglion for maxillary trigeminal neuralgia: a retrospective analysis of 1070 patients with minimum 2-year follow-up. 62
36148904 2022
Endoscopic microvascular decompression without the use of rigid head fixation. 62
36371300 2022
Ca V 3.2 calcium channels contribute to trigeminal neuralgia. 62
35467587 2022
The omega of TRPM7 channels in trigeminal neuralgia. 62
36197528 2022
Melancholia as psychalgia: the integration of psychophysiological theory and psychopathologic observation in the mid-19th century. 62
36473999 2022
Development of label-free electrochemical impedance spectroscopy for the detection of HLA-B*15:02 and HLA-B*15:21 for the prevention of carbamazepine-induced Stevens-Johnson syndrome. 62
36191668 2022
Cellular Mechanisms Mediating the Antinociceptive Effect of Botulinum Toxin A in a Rodent Model of Trigeminal Irritation by a Foreign Body. 62
36087907 2022
Refractory glossopharyngeal neuralgia successfully treated with onabotulinumtoxinA: A case report. 62
36373801 2022
Coexistence of neurovascular compression syndrome and unruptured cerebral aneurysm. 62
36057158 2022
Reactive Oxygen Species Enlightened Therapeutic Strategy for Oral and Maxillofacial Diseases-Art of Destruction and Reconstruction. 62
36428473 2022
Atypical painful stroke presentations: A review. 62
35788546 2022
Mind-body therapies in traditional Chinese medicine for Neuropathic Pain: A Systematic Review of Randomized Controlled Trials. 62
36400656 2022
Assessment of epidermoid cyst with trigeminal neuralgia before neuroendoscopy: A high-resolution MR study based on 3D-FIESTA and MR angiography. 62
35973272 2022
Percutaneous balloon compression for trigeminal neuralgia: a how I do it. 62
35585283 2022
Percutaneous balloon compression for secondary trigeminal neuralgia caused by cerebellopontine angle tumors. 62
35596810 2022
A case of secondary trigeminal neuralgia due to lateral medullary syndrome treated with trigeminal ganglion radiofrequency ablation. 62
36039859 2022
Safety and efficacy of erenumab in patients with trigeminal neuralgia in Denmark: a double-blind, randomised, placebo-controlled, proof-of-concept study. 62
36113495 2022
Ultrasound-guided dry needling of masticatory muscles in trigeminal neuralgia - A case series of 35 patients. 62
36453389 2022
Treatment of multiple sclerosis-related trigeminal neuralgia with onabotulinumtoxinA. 62
36437599 2022
Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents. 62
36443951 2022
Meckel's Cave Size Measured by Magnetic Resonance Imaging in the Prognosis of Percutaneous Balloon Compression for Trigeminal Neuralgia. 62
36375201 2022
Pulsed Radiofrequency for the Treatment of Trigeminal Neuralgia. 62
36378398 2022
Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia. 62
36397158 2022
MRI lesions can often precede trigeminal neuralgia symptoms by years in multiple sclerosis. 62
36396446 2022
Management of Trigeminal Neuralgia with Botulinum Toxin Type A: Report of Two Cases. 62
36354652 2022
Trigeminal neuralgia and the merit of small clinical trials. 62
36113494 2022
Increase in Trigeminal Nerve Cross-Sectional Area on Immediate Postoperative MRI Predicts Favorable Outcome After Microvascular Decompression for Classical Trigeminal Neuralgia. 62
36399422 2022
Fluorescence visualization of the neuropathic pain triad in trigeminal neuralgia. 62
36369929 2022
Stereotactic radiosurgery for trigeminal neuralgia secondary to tumor: a single-institution retrospective series. 62
36321284 2022

Variations for Trigeminal Neuralgia

Expression for Trigeminal Neuralgia

Search GEO for disease gene expression data for Trigeminal Neuralgia.

Pathways for Trigeminal Neuralgia

Pathways related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
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11 10.89 SCN9A SCN8A SCN3A SCN11A SCN10A
12 10.51 SCN9A SCN8A SCN3A SCN11A SCN10A

GO Terms for Trigeminal Neuralgia

Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.43 TRPV1 TRPM7 SLC6A4 SCN9A P2RX3 NTRK1
2 plasma membrane GO:0005887 10.43 TRPV1 TRPM7 SLC6A4 SCN9A P2RX3 NTRK1
3 membrane GO:0016020 10.41 CACNA1A CACNA1H COMT ESR1 KANTR NTRK1
4 membrane GO:0016021 10.41 CACNA1A CACNA1H COMT ESR1 KANTR NTRK1
5 neuronal cell body GO:0043025 10.07 TRPV1 TAC1 SCN11A P2RX3 NTRK1 CALCA
6 neuron projection GO:0043005 9.97 TRPV1 SLC6A4 SCN9A P2RX3 CALCA CACNA1H
7 axon GO:0030424 9.96 BDNF CALCA COMT NTRK1 P2RX3 SCN10A
8 obsolete integral component of presynaptic membrane GO:0099056 9.5 P2RX3 SCN10A SLC6A4
9 voltage-gated sodium channel complex GO:0001518 9.4 SCN9A SCN8A SCN3A SCN11A SCN10A CACNA1H

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 regulation of monoatomic ion transmembrane transport GO:0034765 10.32 CACNA1A CACNA1H SCN10A SCN11A SCN3A SCN8A
2 sodium ion transmembrane transport GO:0035725 10.3 SLC6A4 SCN9A SCN8A SCN3A SCN11A SCN10A
3 positive regulation of cytosolic calcium ion concentration GO:0007204 10.27 TRPV1 TAC1 ESR1 CALCA CACNA1A
4 calcium ion transmembrane transport GO:0070588 10.22 TRPV1 TRPM7 SCN11A CACNA1H CACNA1A
5 sodium ion transport GO:0006814 10.21 SCN10A SCN11A SCN3A SCN8A SCN9A
6 cellular response to nerve growth factor stimulus GO:1990090 10.15 TRPV1 TAC1 NTRK1 CALCA
7 sensory perception of pain GO:0019233 10.14 TRPV1 TAC1 SCN9A SCN10A NTRK1
8 response to heat GO:0009408 10.13 CALCA P2RX3 SCN11A SCN9A TRPV1
9 transmembrane transport GO:0055085 10.1 TRPV1 TRPM7 SLC6A4 SCN9A SCN8A SCN3A
10 monoatomic ion transport GO:0006811 10.07 TRPV1 TRPM7 SCN9A SCN8A SCN3A SCN11A
11 circadian rhythm GO:0007623 10.06 SLC6A4 SCN9A SCN11A NTRK1
12 response to pain GO:0048265 10.05 TRPV1 TAC1 GCH1 CALCA
13 detection of temperature stimulus involved in sensory perception of pain GO:0050965 10.03 CALCA NTRK1 SCN11A SCN9A TRPV1
14 calcium ion transport GO:0006816 10 TRPV1 TRPM7 CACNA1H CACNA1A
15 membrane depolarization during action potential GO:0086010 9.93 CACNA1H SCN10A SCN11A SCN3A SCN8A SCN9A
16 monoatomic ion transmembrane transport GO:0034220 9.91 TRPV1 SCN9A SCN8A SCN3A SCN11A SCN10A
17 behavioral response to pain GO:0048266 9.89 TRPV1 SCN9A SCN3A P2RX3
18 behavioral response to formalin induced pain GO:0061368 9.87 NTRK1 P2RX3 SCN11A SCN9A
19 neuronal action potential GO:0019228 9.8 SCN9A SCN8A SCN3A SCN11A SCN10A P2RX3
20 urinary bladder smooth muscle contraction GO:0014832 9.78 TRPV1 P2RX3
21 calcitonin gene-related peptide receptor signaling pathway GO:1990408 9.59 SCN11A CALCA
22 monoatomic cation transmembrane transport GO:0098655 9.28 TRPM7 SCN9A SCN8A SCN3A SCN11A SCN10A

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated monoatomic ion channel activity GO:0005244 10.03 SCN9A SCN8A SCN3A SCN11A SCN10A CACNA1H
2 voltage-gated sodium channel activity GO:0005248 9.93 CACNA1H SCN10A SCN11A SCN3A SCN8A SCN9A
3 calcium channel activity GO:0005262 9.85 TRPV1 TRPM7 CACNA1H CACNA1A
4 voltage-gated calcium channel activity GO:0005245 9.8 TRPV1 CACNA1H CACNA1A
5 sodium channel activity GO:0005272 9.72 SCN9A SCN8A SCN3A SCN11A SCN10A
6 monoatomic cation channel activity GO:0005261 9.61 TRPV1 TRPM7 SCN9A SCN8A SCN3A SCN11A
7 monoatomic ion channel activity GO:0005216 9.36 TRPV1 TRPM7 SCN9A SCN8A SCN3A SCN11A

Sources for Trigeminal Neuralgia

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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