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MCID: TRG002
MIFTS: 57

Trigeminal Neuralgia

Categories: Rare diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Trigeminal Neuralgia

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MalaCards integrated aliases for Trigeminal Neuralgia:

Name: Trigeminal Neuralgia 57 12 76 53 54 59 29 55 43 44 15 73
Tic Douloureux 57 53 54
Trifacial Neuralgia 12
Trifocal Neuralgia 12

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant form


HPO:

32
trigeminal neuralgia:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare neurological diseases


External Ids:

OMIM 57 190400
Disease Ontology 12 DOID:12098
ICD10 33 G50.0
ICD9CM 35 350.1
MeSH 44 D014277
Orphanet 59 ORPHA221091
MESH via Orphanet 45 D014277
UMLS via Orphanet 74 C0040997
ICD10 via Orphanet 34 G50.0
MedGen 42 C0040997
SNOMED-CT via HPO 69 263681008 88425004
UMLS 73 C0040997
Sources

Summaries for Trigeminal Neuralgia

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NINDS : 54 Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary : Trigeminal Neuralgia, also known as tic douloureux, is related to burning mouth syndrome and postpartum depression, and has symptoms including back pain, facial pain and headache. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are L1CAM interactions and Phase 0 - rapid depolarisation. The drugs Bupivacaine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related phenotypes are abnormality of the nervous system and trigeminal neuralgia

NIH Rare Diseases : 53 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theĀ face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.

MedlinePlus : 43 Trigeminal neuralgia (TN) is a type of chronic pain that affects your face. It causes extreme, sudden burning or shock-like pain. It usually affects one side of the face. Any vibration on your face, even from talking, can set it off. The condition may come and go, disappearing for days or even months. But the longer you have it, the less often it goes away. TN usually affects people over 50, especially women. The cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. Tumors and multiple sclerosis can also cause TN, but in some cases the cause is unknown. There is no single test to diagnose TN. It can be hard to diagnose, since many other conditions can cause facial pain. Treatment options include medicines, surgery, and complementary techniques. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Trigeminal neuralgia (TN or TGN) is a chronic pain disorder that affects the trigeminal nerve. There are... more...

Description from OMIM: 190400
Sources

Related Diseases for Trigeminal Neuralgia

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Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 burning mouth syndrome 30.6 SCN9A TRPV1
2 postpartum depression 30.3 ESR1 SLC6A4
3 paine syndrome 30.3 SCN10A SCN9A TRPV1
4 neuroma 30.0 SCN10A TRPV1
5 glossopharyngeal neuralgia 11.6
6 headache 11.5
7 paroxysmal hemicrania 11.4
8 sunct headache 11.4
9 hemifacial atrophy, progressive 11.1
10 epidermoid brain cyst 11.1
11 trigeminal trophic syndrome 11.1
12 sodium channelopathy-related small fiber neuropathy 10.6 SCN10A SCN9A
13 erythermalgia, primary 10.6 SCN10A SCN9A
14 indifference to pain, congenital, autosomal recessive 10.6 SCN10A SCN9A
15 erythromelalgia 10.6 SCN10A SCN9A
16 hemifacial spasm 10.5
17 multiple sclerosis 10.5
18 mononeuritis of lower limb 10.5 SCN10A TRPV1
19 lesion of sciatic nerve 10.5 SCN10A TRPV1
20 retinitis pigmentosa 20 10.5 ESR1 SLC6A4
21 sciatic neuropathy 10.4 SCN10A TRPV1
22 somatoform disorder 10.4 SCN9A TRPV1
23 dyspepsia 10.3 SLC6A4 TRPV1
24 bone resorption disease 10.2 ESR1 TRPV1
25 arteriovenous malformation 10.2
26 bone remodeling disease 10.2 ESR1 TRPV1
27 cranial nerve disease 10.2 MBD1 TRPV1
28 depression 10.2
29 paroxysmal extreme pain disorder 10.2 SCN10A SCN9A TRPV1
30 arachnoiditis 10.2
31 female reproductive system disease 10.1 ESR1 TRPV1
32 irritable bowel syndrome 10.1 SLC6A4 TRPV1
33 peripheral nervous system disease 10.1 SCN9A TRPV1
34 aging 10.1
35 cerebellopontine angle tumor 10.1
36 arachnoid cysts 10.1
37 hydrocephalus 10.1
38 cavernous malformation 10.1
39 persistent idiopathic facial pain 10.1
40 epidermoid cysts 10.0
41 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
42 arteriovenous fistula 10.0
43 burns 10.0
44 neuropathy 10.0
45 aneurysm 10.0
46 postherpetic neuralgia 10.0
47 migraine with or without aura 1 10.0 ESR1 SLC6A4 TRPV1
48 facial spasm 9.9
49 temporal arteritis 9.9
50 anxiety 9.9

Comorbidity relations with Trigeminal Neuralgia via Phenotypic Disease Network (PDN):


Acute Cystitis Glossopharyngeal Neuralgia
Hypertension, Essential Hypothyroidism
Multiple Sclerosis

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to Trigeminal Neuralgia
Sources

Symptoms & Phenotypes for Trigeminal Neuralgia

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Symptoms via clinical synopsis from OMIM:

57
Neuro:
trigeminal neuralgia


Clinical features from OMIM:

190400

Human phenotypes related to Trigeminal Neuralgia:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 32 HP:0000707
2 trigeminal neuralgia 32 HP:0100661

UMLS symptoms related to Trigeminal Neuralgia:


back pain, facial pain, headache, neuralgia, pain, sciatica, seizures, syncope, tremor, chronic pain, atypical facial pain, orofacial pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 CRLF1 ESR1 MBD1 SCN10A SCN3A SCN9A
2 nervous system MP:0003631 9.17 CRLF1 ESR1 MBD1 SCN10A SCN9A SLC6A4
Sources

Drugs & Therapeutics for Trigeminal Neuralgia

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Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Artemether Approved Phase 4 71963-77-4 119380 68911
5
Lumefantrine Approved Phase 4 82186-77-4 6437380
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
7
Acetylcholine Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-84-3 187
8
Carbamazepine Approved, Investigational Phase 4,Phase 2,Phase 3 298-46-4 2554
9
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
10
Ondansetron Approved Phase 4 99614-02-5 4595
11
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
12
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
13
Oxcarbazepine Approved Phase 4 28721-07-5 34312
14 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
15 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
16 Anesthetics, Local Phase 4,Phase 2,Phase 3,Not Applicable
17 Antiemetics Phase 4
18 Anti-Inflammatory Agents Phase 4
19 Antineoplastic Agents, Hormonal Phase 4
20 Autonomic Agents Phase 4
21 BB 1101 Phase 4,Not Applicable
22 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
23 Dexamethasone acetate Phase 4,Not Applicable 1177-87-3
24 Gastrointestinal Agents Phase 4
25 glucocorticoids Phase 4
26 HIV Protease Inhibitors Phase 4
27 Hormone Antagonists Phase 4
28 Hormones Phase 4
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
30 Immunosuppressive Agents Phase 4
31 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
32
protease inhibitors Phase 4
33 triamcinolone acetonide Phase 4
34 Triamcinolone diacetate Phase 4
35 Triamcinolone hexacetonide Phase 4
36 Anthelmintics Phase 4
37 Antifungal Agents Phase 4,Not Applicable
38 Anti-Infective Agents Phase 4,Not Applicable
39 Antimalarials Phase 4
40 Antiparasitic Agents Phase 4
41 Antiprotozoal Agents Phase 4
42 Artemether-lumefantrine combination Phase 4
43 Artemisinine Phase 4
44 Artemisinins Phase 4
45 abobotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
46 Botulinum Toxins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
47 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
48 Cholinergic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
49 Neuromuscular Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
50 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
2 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed NCT02024724 Phase 4 Bupivacaine;Triamcinolone;Dexamethasone
3 A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) Completed NCT01256658 Phase 4 COA566
4 (Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist Recruiting NCT03381261 Phase 4 Botulinum toxin type A
5 Postoperative Analgesia in Patients With Microvascular Decompression Active, not recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
6 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
7 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
8 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3 Levobupivacaine;Bupivacaine
9 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
10 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
11 Botulinum Toxin Injections for Oral Neuropathic Pain Not yet recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
12 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
13 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
14 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
15 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
16 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
17 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
18 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
19 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Recruiting NCT02624661 Phase 1, Phase 2 Glycerol
20 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Active, not recruiting NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
21 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
22 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
23 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
24 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
25 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1
26 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
27 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
28 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
29 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia Completed NCT03549013
30 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406 Not Applicable
31 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Completed NCT01761604 Not Applicable
32 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 Not Applicable lamotrigine;Placebo
33 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 Not Applicable L-baclofen
34 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Not Applicable Lidocaine
35 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807 Not Applicable
36 Hippocampal Radiation Exposure and Memory Completed NCT00603694
37 A Study of Intra-dermal Injection of Botulinum Toxin Type A for the Diabetic Neuropathic Foot Pain Completed NCT00336349 Not Applicable Botulinum Toxin Type A
38 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
39 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810 Not Applicable
40 High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia Recruiting NCT03131466 Not Applicable Nerve block
41 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Recruiting NCT02801630 Not Applicable
42 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323
43 An Follow-up Study of Occlusal Adjustment for Orofacial Pain Recruiting NCT02856906 Not Applicable
44 Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy Recruiting NCT01632657 Not Applicable Sumatriptan;Placebo
45 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
46 Comparison Between Radiofrequency and Balloon Compression in the Treatment of Idiopathic Trigeminal Neuralgia Active, not recruiting NCT02427074 Not Applicable
47 RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT Enrolling by invitation NCT01885299
48 Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia Not yet recruiting NCT03580317 Not Applicable
49 FMRI Assessment After Radiofrequency in Trigeminal Neuralgia Not yet recruiting NCT03305289 Not Applicable
50 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: trigeminal neuralgia

Sources

Genetic Tests for Trigeminal Neuralgia

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Genetic tests related to Trigeminal Neuralgia:

# Genetic test Affiliating Genes
1 Trigeminal Neuralgia 29
Sources

Anatomical Context for Trigeminal Neuralgia

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MalaCards organs/tissues related to Trigeminal Neuralgia:

41
Brain, Testes, Skin, Trigeminal Ganglion, Liver, Cortex, Bone
Sources

Publications for Trigeminal Neuralgia

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Articles related to Trigeminal Neuralgia:

(show top 50) (show all 919)
# Title Authors Year
1
Trigeminal Neuralgia due to Vertebrobasilar Artery Compression. ( 29959080 )
2018
2
The timing of stereotactic radiosurgery for medically refractory trigeminal neuralgia: the evidence from diffusion tractography images. ( 29397449 )
2018
3
Therapeutic failure in trigeminal neuralgia: from a clarification of trigeminal nerve somatotopy to a targeted partial sensory rhizotomy. ( 29883821 )
2018
4
Pain-Free outcomes and Durability of Surgical Intervention for Trigeminal Neuralgia: A Comparison of Gamma Knife and Microvascular Decompression. ( 29382615 )
2018
5
Management of Primary Bilateral Trigeminal Neuralgia with Microvascular Decompression: 13-Case Series. ( 29066316 )
2018
6
Quantitative analysis of the safety and efficacy of microvascular decompression for patients with trigeminal neuralgia above and below 65a8^years of age. ( 29954647 )
2018
7
Extensive Craniocervical Abscess after Transoral Ganglionic Local Opioid Analgesia at the Superior Cervical Ganglion for Atypical Trigeminal Neuralgia: Report of a Severely Complicated Case. ( 29977303 )
2018
8
Dosimetric comparison of sector-blocked and non-sector-blocked Gamma Knife Perfexion treatment plans for trigeminal neuralgia. ( 29395459 )
2018
9
Surgical Management of Familial Trigeminal Neuralgia With Different Inheritance Patterns: A Case Report. ( 29867726 )
2018
10
Altered structure and functional connection in patients with classical trigeminal neuralgia. ( 29105886 )
2018
11
Intra- and postoperative bleeding in microvascular decompression for trigeminal neuralgia. ( 29959070 )
2018
12
Letter to the Editor. Cafeteria approach to management of trigeminal neuralgia: stereotactic radiosurgery as a preferred option. ( 29957108 )
2018
13
Immediate and Long-term Outcomes of Microvascular Decompression for Mixed Trigeminal Neuralgia. ( 29906578 )
2018
14
Trigeminal Neuralgia Secondary to Osteoid Osteoma of the Petrous Bone: Report of 4 Cases and Brief Review of Literature. ( 29551722 )
2018
15
Bridging veins and veins of the brainstem in microvascular decompression surgery for trigeminal neuralgia and hemifacial spasm. ( 29961378 )
2018
16
Prognostic factors for outcome of microvascular decompression in trigeminal neuralgia: A prospective systematic study using independent assessors. ( 29896973 )
2018
17
Awake Microvascular Decompression for Trigeminal Neuralgia: Concept and Initial Results. ( 29452326 )
2018
18
Trigeminal Nerve Compression Without Trigeminal Neuralgia: Intraoperative vs Imaging Evidence. ( 29425330 )
2018
19
Multivariate Pattern Classification of Brain White Matter Connectivity Predicts Classic Trigeminal Neuralgia. ( 29905649 )
2018
20
Computed tomography-guided percutaneous ozone injection of the Gasserian ganglion for the treatment of trigeminal neuralgia. ( 29430195 )
2018
21
Cystic Progression of a Cavernous Malformation at the Level of the Trigeminal Root Entry Zone Presenting With Sudden Onset of Trigeminal Neuralgia. ( 29570519 )
2018
22
Early Stereotactic Radiosurgery for Medically Refractory Trigeminal Neuralgia. ( 29371169 )
2018
23
Editors' note: Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. ( 29378922 )
2018
24
Validation of MLC-based linac radiosurgery for trigeminal neuralgia. ( 29901278 )
2018
25
Measuring the impact of trigeminal neuralgia pain: the Penn Facial Pain Scale-Revised. ( 29892203 )
2018
26
Successive occurrence of vertebrobasilar dolichectasia induced trigeminal neuralgia, vestibular paroxysmia and hemifacial spasm: A case report. ( 29924039 )
2018
27
Trigeminal Neuralgia in Pregnancy: A Management Challenge. ( 28574640 )
2018
28
Reader response: Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. ( 29378923 )
2018
29
Effect of coenzyme Q10 on mitochondrial respiratory proteins in trigeminal neuralgia. ( 29424256 )
2018
30
Abnormal brain white matter in patients with right trigeminal neuralgia: a diffusion tensor imaging study. ( 29931400 )
2018
31
Characterizing Treatment Utilization Patterns for Trigeminal Neuralgia in the United States. ( 29443722 )
2018
32
Author response: Teaching NeuroImages: Amlodipine-responsive trigeminal neuralgia: An alibi for vascular compression theory. ( 29378924 )
2018
33
Long-term follow-up of multimodality treatment for multiple sclerosis-related trigeminal neuralgia. ( 29167978 )
2018
34
Curcumin alleviates pain and improves cognitive impairment in a rat model of cobra venom-induced trigeminal neuralgia. ( 29950886 )
2018
35
Diffusion Tensor Imaging of Axonal and Myelin Changes in Classical Trigeminal Neuralgia. ( 29410338 )
2018
36
Therapeutic and Analgesic Efficacy of Laser in Conjunction With Pharmaceutical Therapy for Trigeminal Neuralgia. ( 29399314 )
2018
37
Sixth cranial nerve palsy and ipsilateral trigeminal neuralgia caused by vertebrobasilar dolichoectasia. ( 29780939 )
2018
38
Assessment of efficacy and safety of eslicarbazepine acetate for the treatment of trigeminal neuralgia. ( 29369456 )
2018
39
Hemodynamic features of offending vessels at neurovascular contact in patients with trigeminal neuralgia and hemifacial spasm. ( 29979116 )
2018
40
Comparative efficacy and acceptability of antiepileptic drugs for classical trigeminal neuralgia: a Bayesian network meta-analysis protocol. ( 29358420 )
2018
41
Clinical analysis and surgical treatment of trigeminal neuralgia caused by vertebrobasilar dolichoectasia: A retrospective study. ( 28392449 )
2017
42
Gamma Knife Radiosurgery for Idiopathic Trigeminal Neuralgia; does the status of offending vessels influence on pain control or side effects? ( 28532912 )
2017
43
The role of radiosurgery in trigeminal neuralgia. ( 28527088 )
2017
44
Diagnosis and management for trigeminal neuralgia caused solely by venous compression. ( 28108856 )
2017
45
Stereotactic Radiosurgery for Trigeminal Neuralgia Improves Patient-Reported Quality of Life and Reduces Depression. ( 28721891 )
2017
46
Radial Extracorporeal Shock Wave Therapy in an Individual With Primary Trigeminal Neuralgia: A Case Report and Literature Review. ( 28961605 )
2017
47
Postherpetic neuralgia, diabetic neuropathy, and trigeminal neuralgia - Chronic peripheral neuropathic pain in 58,480 rural Italian primary care patients. ( 29026761 )
2017
48
Nerve Combing for Trigeminal Neuralgia Without Vascular Compression. ( 27875506 )
2017
49
Phenytoin and carbamazepine in trigeminal neuralgia: marketing-based versus evidence-based treatment. ( 28761370 )
2017
50
Trigeminal neuralgia. ( 28033174 )
2017
Sources

Variations for Trigeminal Neuralgia

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Expression for Trigeminal Neuralgia

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Search GEO for disease gene expression data for Trigeminal Neuralgia.
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Pathways for Trigeminal Neuralgia

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Pathways related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
L1CAM interactions 66
Show member pathways
 11.43 SCN10A SCN3A SCN9A
2
Phase 0 - rapid depolarisation 66
Show member pathways
 11.01 SCN10A SCN3A SCN9A
3
Interaction between L1 and Ankyrins 66
10.28 SCN10A SCN3A SCN9A
Sources

GO Terms for Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated sodium channel complex GO:0001518 8.8 SCN10A SCN3A SCN9A

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.76 SCN10A SCN3A SCN9A TRPV1
2 ion transmembrane transport GO:0034220 9.65 SCN3A SCN9A TRPV1
3 transmembrane transport GO:0055085 9.65 SCN10A SCN3A SCN9A SLC6A4 TRPV1
4 regulation of ion transmembrane transport GO:0034765 9.61 SCN10A SCN3A SCN9A
5 sodium ion transport GO:0006814 9.58 SCN10A SCN3A SCN9A
6 sodium ion transmembrane transport GO:0035725 9.5 SCN10A SCN3A SCN9A
7 behavioral response to pain GO:0048266 9.37 SCN9A TRPV1
8 sensory perception of pain GO:0019233 9.33 SCN10A SCN9A TRPV1
9 membrane depolarization during action potential GO:0086010 9.13 SCN10A SCN3A SCN9A
10 neuronal action potential GO:0019228 8.8 SCN10A SCN3A SCN9A

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.56 SCN10A SCN3A SCN9A TRPV1
2 voltage-gated ion channel activity GO:0005244 9.5 SCN10A SCN3A SCN9A
3 sodium channel activity GO:0005272 9.33 SCN10A SCN3A SCN9A
4 voltage-gated sodium channel activity GO:0005248 9.13 SCN10A SCN3A SCN9A
5 cation channel activity GO:0005261 8.92 SCN10A SCN3A SCN9A TRPV1
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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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