Trigeminal Neuralgia

Categories: Blood diseases, Neuronal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Trigeminal Neuralgia

MalaCards integrated aliases for Trigeminal Neuralgia:

Name: Trigeminal Neuralgia 58 12 77 54 55 60 30 56 44 45 15 17 74
Tic Douloureux 58 54 55
Trifacial Neuralgia 12
Trifocal Neuralgia 12



autosomal dominant form


trigeminal neuralgia:
Inheritance autosomal dominant inheritance


Orphanet: 60  
Rare neurological diseases

External Ids:

Disease Ontology 12 DOID:12098
OMIM 58 190400
ICD9CM 36 350.1
MeSH 45 D014277
SNOMED-CT 69 31681005
ICD10 34 G50.0
MESH via Orphanet 46 D014277
ICD10 via Orphanet 35 G50.0
UMLS via Orphanet 75 C0040997
Orphanet 60 ORPHA221091
MedGen 43 C0040997
UMLS 74 C0040997

Summaries for Trigeminal Neuralgia

NINDS : 55 Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary : Trigeminal Neuralgia, also known as tic douloureux, is related to postpartum depression and glossopharyngeal neuralgia, and has symptoms including seizures, tremor and back pain. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are L1CAM interactions and Phase 0 - rapid depolarisation. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and trigeminal ganglion, and related phenotypes are trigeminal neuralgia and depressivity

NIH Rare Diseases : 54 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.

MedlinePlus : 44 Trigeminal neuralgia (TN) is a type of chronic pain that affects your face. It causes extreme, sudden burning or shock-like pain. It usually affects one side of the face. Any vibration on your face, even from talking, can set it off. The condition may come and go, disappearing for days or even months. But the longer you have it, the less often it goes away. TN usually affects people over 50, especially women. The cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. Tumors and multiple sclerosis can also cause TN, but in some cases the cause is unknown. There is no single test to diagnose TN. It can be hard to diagnose, since many other conditions can cause facial pain. Treatment options include medicines, surgery, and complementary techniques. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 77 Trigeminal neuralgia (TN or TGN) is a chronic pain disorder that affects the trigeminal nerve. There are... more...

Description from OMIM: 190400

Related Diseases for Trigeminal Neuralgia

Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 postpartum depression 29.9 ESR1 SLC6A4
2 glossopharyngeal neuralgia 11.8
3 headache 11.7
4 sunct headache 11.6
5 paroxysmal hemicrania 11.6
6 hemifacial atrophy, progressive 11.6
7 epidermoid brain cyst 11.3
8 trigeminal trophic syndrome 11.3
9 multiple sclerosis 10.9
10 hemifacial spasm 10.8
11 arteriovenous malformation 10.6
12 persistent idiopathic facial pain 10.4
13 arteriovenous fistula 10.4
14 arachnoid cysts 10.4
15 hydrocephalus 10.3
16 herpes simplex 10.3
17 depression 10.3
18 acoustic neuroma 10.3
19 epilepsy 10.3
20 neurilemmoma 10.3
21 cluster headache 10.3
22 enthesopathy 10.3
23 sodium channelopathy-related small fiber neuropathy 10.3 SCN10A SCN9A
24 epidermoid cysts 10.3
25 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
26 sinusitis 10.3
27 neuropathy 10.3
28 cavernous malformation 10.3
29 indifference to pain, congenital, autosomal recessive 10.2 SCN10A SCN9A
30 erythermalgia, primary 10.2 SCN10A SCN9A
31 paroxysmal extreme pain disorder 10.2 SCN10A SCN9A
32 lipomatosis, multiple 10.2
33 brittle bone disorder 10.2
34 anxiety 10.2
35 lymphoma 10.2
36 pleomorphic lipoma 10.2
37 col1a1/2-related osteogenesis imperfecta 10.2
38 erythromelalgia 10.2 SCN10A SCN9A
39 migraine with or without aura 1 10.1
40 meningioma, familial 10.1
41 charcot-marie-tooth disease 10.1
42 tooth disease 10.1
43 cholesteatoma of middle ear 10.1
44 spinal meningioma 10.1
45 squamous cell carcinoma 10.1
46 neuroma 10.1
47 secretory meningioma 10.1
48 pain - chronic 10.1
49 postherpetic neuralgia 10.1
50 syncope 10.1

Comorbidity relations with Trigeminal Neuralgia via Phenotypic Disease Network (PDN):

Acute Cystitis Glossopharyngeal Neuralgia
Hypertension, Essential Hypothyroidism
Multiple Sclerosis

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:

Diseases related to Trigeminal Neuralgia

Symptoms & Phenotypes for Trigeminal Neuralgia

Human phenotypes related to Trigeminal Neuralgia:

60 33 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 trigeminal neuralgia 60 33 obligate (100%) Obligate (100%) HP:0100661
2 depressivity 60 33 hallmark (90%) Very frequent (99-80%) HP:0000716
3 cluster headache 60 33 hallmark (90%) Very frequent (99-80%) HP:0012199
4 allodynia 60 33 hallmark (90%) Very frequent (99-80%) HP:0012533
5 feeding difficulties 60 33 frequent (33%) Frequent (79-30%) HP:0011968
6 paresthesia 60 33 frequent (33%) Frequent (79-30%) HP:0003401
7 sensory impairment 60 33 frequent (33%) Frequent (79-30%) HP:0003474
8 difficulty in tongue movements 60 33 frequent (33%) Frequent (79-30%) HP:0000183
9 poor speech 60 33 frequent (33%) Frequent (79-30%) HP:0002465
10 episodic paroxysmal anxiety 60 33 frequent (33%) Frequent (79-30%) HP:0000740
11 vascular tortuosity 60 33 frequent (33%) Frequent (79-30%) HP:0004948
12 mandibular pain 60 33 frequent (33%) Frequent (79-30%) HP:0200025
13 neoplasm 60 33 occasional (7.5%) Occasional (29-5%) HP:0002664
14 peripheral demyelination 60 33 occasional (7.5%) Occasional (29-5%) HP:0011096
15 ocular pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0200026
16 cranial nerve compression 60 33 occasional (7.5%) Occasional (29-5%) HP:0001293
17 cns demyelination 60 33 occasional (7.5%) Occasional (29-5%) HP:0007305
18 abnormality of the nervous system 33 HP:0000707

Symptoms via clinical synopsis from OMIM:

trigeminal neuralgia

Clinical features from OMIM:


UMLS symptoms related to Trigeminal Neuralgia:

seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia, facial pain, atypical facial pain, orofacial pain

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 CRLF1 ESR1 JMJD6 MBD1 SCN10A SCN3A
2 nervous system MP:0003631 9.17 CRLF1 ESR1 JMJD6 MBD1 SCN10A SCN9A

Drugs & Therapeutics for Trigeminal Neuralgia

Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Not Applicable 1177-87-3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
Lumefantrine Approved Phase 4 82186-77-4 6437380
Artemether Approved Phase 4 71963-77-4 119380 68911
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-84-3 187
Ondansetron Approved Phase 4 99614-02-5 4595
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Oxcarbazepine Approved Phase 4 28721-07-5 34312
13 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
14 Antiemetics Phase 4
15 Antineoplastic Agents, Hormonal Phase 4
16 Hormone Antagonists Phase 4
17 Immunologic Factors Phase 4
18 Triamcinolone diacetate Phase 4
19 triamcinolone acetonide Phase 4
20 Gastrointestinal Agents Phase 4
21 glucocorticoids Phase 4
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
23 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
24 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Triamcinolone hexacetonide Phase 4
26 Anti-Inflammatory Agents Phase 4
27 HIV Protease Inhibitors Phase 4
28 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
protease inhibitors Phase 4
30 Autonomic Agents Phase 4
31 BB 1101 Phase 4,Not Applicable
32 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
33 Anesthetics, Local Phase 4,Phase 2,Phase 3,Not Applicable
34 Immunosuppressive Agents Phase 4
35 Antimalarials Phase 4
36 Anti-Infective Agents Phase 4,Not Applicable
37 Artemether, Lumefantrine Drug Combination Phase 4
38 Antiprotozoal Agents Phase 4
39 Antiparasitic Agents Phase 4
40 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
41 Acetylcholine Release Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
42 Cholinergic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
44 Neuromuscular Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
45 Botulinum Toxins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
46 abobotulinumtoxinA Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
47 Analgesics, Opioid Phase 4
48 Excitatory Amino Acid Antagonists Phase 4,Phase 2
49 Psychotropic Drugs Phase 4,Phase 2,Phase 3,Not Applicable
50 Antipsychotic Agents Phase 4,Phase 2,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
2 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed NCT02024724 Phase 4 Bupivacaine;Triamcinolone;Dexamethasone
3 A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) Completed NCT01256658 Phase 4 COA566
4 (Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist Recruiting NCT03381261 Phase 4 Botulinum toxin type A
5 Postoperative Analgesia in Patients With Microvascular Decompression Active, not recruiting NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
6 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
7 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
8 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3 Levobupivacaine;Bupivacaine
9 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
10 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
11 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
12 Botulinum Toxin Injections for Oral Neuropathic Pain Not yet recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
13 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
14 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
15 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
16 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
17 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
18 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
19 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
20 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
21 Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy Not yet recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
22 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
23 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Terminated NCT02624661 Phase 1, Phase 2 Glycerol
24 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
25 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
26 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
27 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
28 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
29 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630 Not Applicable
30 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
31 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
32 Classical Trigeminal Neuralgia and Sodium Channel Mutations Completed NCT03656497
33 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia Completed NCT03549013
34 Prognosis of Trigeminal Neuralgia When Enrolled in a Multidisciplinary Management Program Completed NCT03838393
35 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406 Not Applicable
36 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Completed NCT01761604 Not Applicable
37 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 Not Applicable lamotrigine;Placebo
38 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 Not Applicable L-baclofen
39 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Not Applicable Lidocaine
40 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807 Not Applicable
41 Hippocampal Radiation Exposure and Memory Completed NCT00603694
42 A Study of Intra-dermal Injection of Botulinum Toxin Type A for the Diabetic Neuropathic Foot Pain Completed NCT00336349 Not Applicable Botulinum Toxin Type A
43 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
44 Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital Recruiting NCT03669744
45 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810 Not Applicable
46 Neurophysiologic Signatures of Trigeminal Neuralgia Pain Recruiting NCT03778177 Not Applicable
47 High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia Recruiting NCT03131466 Not Applicable Nerve block
48 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323
49 An Follow-up Study of Occlusal Adjustment for Orofacial Pain Recruiting NCT02856906 Not Applicable
50 Effect of Sumatriptan on the Postoperative Quality of Recovery After Elective Minimally Invasive Craniotomy Recruiting NCT01632657 Not Applicable Sumatriptan;Placebo

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: trigeminal neuralgia

Genetic Tests for Trigeminal Neuralgia

Genetic tests related to Trigeminal Neuralgia:

# Genetic test Affiliating Genes
1 Trigeminal Neuralgia 30

Anatomical Context for Trigeminal Neuralgia

MalaCards organs/tissues related to Trigeminal Neuralgia:

Brain, Testes, Trigeminal Ganglion, Skin, Tongue, Cortex, Bone

Publications for Trigeminal Neuralgia

Articles related to Trigeminal Neuralgia:

(show top 50) (show all 3065)
# Title Authors Year
Trigeminal Neuralgia Caused by Dural Arteriovenous Fistula in Meckel Cave Treated with Gamma Knife Radiosurgery. ( 30500585 )
Recurrent Secondary Trigeminal Neuralgia Caused by Obliterated Tentorial Dural Arteriovenous Fistula Cured with Surgical Resection: Case Report and Literature Review. ( 30176399 )
A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm. ( 30612530 )
Revision Microvascular Decompression for Trigeminal Neuralgia and Hemifacial Spasm: Factors Associated with Surgical Failure. ( 30733898 )
Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options. ( 30782116 )
One hundred eleven Percutaneous Balloon Compressions for Trigeminal Neuralgia in a Cohort of 66 Patients with Multiple Sclerosis. ( 30690631 )
The possible prognostic role of magnetic resonance imaging findings in patients with trigeminal neuralgia and multiple sclerosis submitted to percutaneous balloon compression. Report of our series and literature review. ( 30716488 )
Stereotactic Radiosurgery for Trigeminal Neuralgia in Patients With Multiple Sclerosis: A Multicenter Study. ( 29688562 )
Comparison of the Neuropathic Pain Symptoms and Psychosocial Impacts of Trigeminal Neuralgia and Painful Posttraumatic Trigeminal Neuropathy. ( 30703173 )
Risk of probable posttraumatic stress disorder in patients with trigeminal neuralgia. ( 30295062 )
Surgical Management of Trigeminal Neuralgia in Children. ( 30347302 )
Evaluation of biochemical variables in patients with trigeminal neuralgia. ( 30527860 )
Patterns of opioid use in patients with trigeminal neuralgia undergoing neurosurgery. ( 30641832 )
Topical Ambroxol 20% for the Treatment of Classical Trigeminal Neuralgia - A New Option? Initial Clinical Case Observations. ( 30653673 )
Comparing Microvascular Decompression with Gamma Knife Radiosurgery for Trigeminal Neuralgia A Cost-effectiveness Analysis. ( 30660885 )
Factors predicting successful outcomes for percutaneous radiofrequency thermocoagulation in patients with idiopathic trigeminal neuralgia: implications for surgical decision making. ( 30675989 )
Acupuncture treatment on idiopathic trigeminal neuralgia: A systematic review protocol. ( 30681609 )
A novel scoring system as a preoperative predictor for pain-free survival after microsurgery for trigeminal neuralgia. ( 30684937 )
Therapeutic efficacy and safety of radiofrequency ablation for the treatment of trigeminal neuralgia: a systematic review and meta-analysis. ( 30697063 )
Acupuncture for primary trigeminal neuralgia: A systematic review and PRISMA-compliant meta-analysis. ( 30712736 )
Sex-dependent posterior fossa anatomical differences in trigeminal neuralgia patients with and without neurovascular compression: a volumetric MRI age- and sex-matched case-control study. ( 30717058 )
Varying length of central myelin along the trigeminal nerve might contribute to trigeminal neuralgia. ( 30719770 )
Effect of Acupuncture on Cognitive Function and Quality of Life in Patients With Idiopathic Trigeminal Neuralgia. ( 30720599 )
Efficacy of Neurectomy of Peripheral Branches of the Trigeminal Nerve in Trigeminal Neuralgia: A Critical Review of the Literature. ( 30728686 )
Greater palatine block for V2 trigeminal neuralgia: Case report. ( 30768727 )
The Herpes simplex's reactivation after surgical treatment of Trigeminal Neuralgia. A retrospective cohort study. ( 30771541 )
Locating the foramen ovale by using molar and inter-eminence planes: a guide for percutaneous trigeminal neuralgia procedures. ( 30771764 )
Effects of long non-coding RNA uc.48+ on pain transmission in trigeminal neuralgia. ( 30772439 )
Fraction of anisotropy and apparent diffusion coefficient as diagnostic tools in trigeminal neuralgia. ( 30790091 )
Application of an artificial neural network model for early outcome prediction of gamma knife radiosurgery in patients with trigeminal neuralgia and determining the relative importance of risk factors. ( 30825722 )
Trigeminal neuralgia due to petrosal bone deformity: a case report. ( 30831302 )
Favourable prognosis of trigeminal neuralgia when enrolled in a multidisciplinary management program - a two-year prospective real-life study. ( 30832577 )
Long-term Follow-up of Patients Treated with Percutaneous Radiofrequency Thermocoagulation via the Foramen Rotundum for Isolated Maxillary Nerve Idiopathic Trigeminal Neuralgia. ( 30835786 )
Radiosurgery for trigeminal neuralgia: the state of art. ( 30838546 )
The efficacy and safety of nerve combing for trigeminal neuralgia without neurovascular compression. ( 30838601 )
Which drug treatments are best for trigeminal neuralgia? ( 30842102 )
Retrosigmoid approach for glycerin rhizotomy in the treatment of trigeminal neuralgia without overt arterial compression: updated case series. ( 30849763 )
A case of trigeminal neuralgia caused by both duplicated superior cerebellar arteries. ( 30860135 )
EAN guideline on trigeminal neuralgia. ( 30860637 )
Time course of pain response and toxicity after whole-nerve-encompassing LINAC-based stereotactic radiosurgery for trigeminal neuralgia-a prospective observational study. ( 30877350 )
A Case of Ophthalmic Branch Trigeminal Neuralgia in the Emergency Department. ( 30891372 )
Pain Outcomes Following Microvascular Decompression for Drug-Resistant Trigeminal Neuralgia: A Systematic Review and Meta-Analysis. ( 30892607 )
Erratum. Endoscopic versus open microvascular decompression for trigeminal neuralgia: a systematic review and comparative meta-analysis. ( 30901749 )
Letter to the Editor. Microvascular decompression for trigeminal neuralgia: does it matter whether the view is through a microscope or via an endoscope? ( 30901752 )
Trigeminal neuralgia in vestibular schwannoma: Atypical presentation and neuroanatomical correlations. ( 30905383 )
Vascular offenders in trigeminal neuralgia: A unified classification and assessment of the outcome of microvascular decompression. ( 30905645 )
ioCT-guided percutaneous radiofrequency ablation for trigeminal neuralgia: how I do it. ( 30911830 )
Preoperative MRI Evaluation of Relationship between Trigeminal Nerve and Superior Petrosal Vein: Its Role in Treating Trigeminal Neuralgia. ( 30913572 )
Successful Microvascular Decompression For Trigeminal Neuralgia Secondary to a Persistent Trigeminal Artery. ( 29554372 )
Older Patients Have Better Pain Outcomes Following Microvascular Decompression for Trigeminal Neuralgia. ( 29562363 )

Variations for Trigeminal Neuralgia

Expression for Trigeminal Neuralgia

Search GEO for disease gene expression data for Trigeminal Neuralgia.

Pathways for Trigeminal Neuralgia

Pathways related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
11.43 SCN10A SCN3A SCN9A
Show member pathways
11.01 SCN10A SCN3A SCN9A
3 10.28 SCN10A SCN3A SCN9A

GO Terms for Trigeminal Neuralgia

Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of presynaptic membrane GO:0099056 8.96 SCN10A SLC6A4
2 voltage-gated sodium channel complex GO:0001518 8.8 SCN10A SCN3A SCN9A

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.67 SCN10A SCN3A SCN9A SLC6A4
2 ion transmembrane transport GO:0034220 9.58 SCN10A SCN3A SCN9A
3 regulation of ion transmembrane transport GO:0034765 9.5 SCN10A SCN3A SCN9A
4 sensory perception of pain GO:0019233 9.43 SCN10A SCN9A
5 sodium ion transport GO:0006814 9.43 SCN10A SCN3A SCN9A
6 sodium ion transmembrane transport GO:0035725 9.33 SCN10A SCN3A SCN9A
7 neuronal action potential GO:0019228 9.13 SCN10A SCN3A SCN9A
8 membrane depolarization during action potential GO:0086010 8.8 SCN10A SCN3A SCN9A

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.43 SCN10A SCN3A SCN9A
2 voltage-gated ion channel activity GO:0005244 9.33 SCN10A SCN3A SCN9A
3 sodium channel activity GO:0005272 9.13 SCN10A SCN3A SCN9A
4 voltage-gated sodium channel activity GO:0005248 8.8 SCN10A SCN3A SCN9A

Sources for Trigeminal Neuralgia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
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