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MCID: TRG002
MIFTS: 60

Trigeminal Neuralgia

Categories: Blood diseases, Neuronal diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Trigeminal Neuralgia

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MalaCards integrated aliases for Trigeminal Neuralgia:

Name: Trigeminal Neuralgia 58 12 77 54 55 60 30 56 44 45 15 17 74
Tic Douloureux 58 54 55
Trifacial Neuralgia 12
Trifocal Neuralgia 12

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant form


HPO:

33
trigeminal neuralgia:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Oral diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12098
OMIM 58 190400
ICD9CM 36 350.1
MeSH 45 D014277
SNOMED-CT 69 31681005
ICD10 34 G50.0
MESH via Orphanet 46 D014277
ICD10 via Orphanet 35 G50.0
UMLS via Orphanet 75 C0040997
Orphanet 60 ORPHA221091
MedGen 43 C0040997
UMLS 74 C0040997
Sources

Summaries for Trigeminal Neuralgia

About this section
NINDS : 55 Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary : Trigeminal Neuralgia, also known as tic douloureux, is related to postpartum depression and glossopharyngeal neuralgia, and has symptoms including seizures, tremor and back pain. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are L1CAM interactions and Phase 0 - rapid depolarisation. The drugs Ketamine and Ondansetron have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and trigeminal ganglion, and related phenotypes are trigeminal neuralgia and depressivity

NIH Rare Diseases : 54 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theĀ face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.

MedlinePlus : 44 Trigeminal neuralgia (TN) is a type of chronic pain that affects your face. It causes extreme, sudden burning or shock-like pain. It usually affects one side of the face. Any vibration on your face, even from talking, can set it off. The condition may come and go, disappearing for days or even months. But the longer you have it, the less often it goes away. TN usually affects people over 50, especially women. The cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. Tumors and multiple sclerosis can also cause TN, but in some cases the cause is unknown. There is no single test to diagnose TN. It can be hard to diagnose, since many other conditions can cause facial pain. Treatment options include medicines, surgery, and complementary techniques. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 77 Trigeminal neuralgia (TN or TGN) is a chronic pain disorder that affects the trigeminal nerve. There are... more...

Description from OMIM: 190400
Sources

Related Diseases for Trigeminal Neuralgia

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Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 postpartum depression 29.9 ESR1 SLC6A4
2 glossopharyngeal neuralgia 11.8
3 headache 11.7
4 sunct headache 11.7
5 paroxysmal hemicrania 11.6
6 hemifacial atrophy, progressive 11.6
7 epidermoid brain cyst 11.3
8 trigeminal trophic syndrome 11.3
9 multiple sclerosis 10.9
10 hemifacial spasm 10.8
11 arteriovenous malformation 10.6
12 persistent idiopathic facial pain 10.5
13 arteriovenous fistula 10.4
14 herpes simplex 10.4
15 arachnoid cysts 10.4
16 depression 10.4
17 neurilemmoma 10.4
18 meningioma, familial 10.3
19 hydrocephalus 10.3
20 spinal meningioma 10.3
21 acoustic neuroma 10.3
22 secretory meningioma 10.3
23 lipomatosis, multiple 10.3
24 pleomorphic lipoma 10.3
25 epilepsy 10.3
26 cluster headache 10.3
27 enthesopathy 10.3
28 epidermoid cysts 10.3
29 anxiety 10.3
30 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
31 sinusitis 10.3
32 neuropathy 10.3
33 cavernous malformation 10.3
34 sodium channelopathy-related small fiber neuropathy 10.3 SCN10A SCN9A
35 indifference to pain, congenital, autosomal recessive 10.2 SCN10A SCN9A
36 erythermalgia, primary 10.2 SCN10A SCN9A
37 paroxysmal extreme pain disorder 10.2 SCN10A SCN9A
38 brittle bone disorder 10.2
39 lymphoma 10.2
40 col1a1/2-related osteogenesis imperfecta 10.2
41 congenital hydrocephalus 10.2
42 erythromelalgia 10.2 SCN10A SCN9A
43 migraine with or without aura 1 10.2
44 charcot-marie-tooth disease 10.2
45 tooth disease 10.2
46 cholesteatoma of middle ear 10.2
47 facial paralysis 10.2
48 squamous cell carcinoma 10.2
49 neuroma 10.2
50 cerebellopontine angle tumor 10.2

Comorbidity relations with Trigeminal Neuralgia via Phenotypic Disease Network (PDN):


Acute Cystitis Glossopharyngeal Neuralgia
Hypertension, Essential Hypothyroidism
Multiple Sclerosis

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to Trigeminal Neuralgia
Sources

Symptoms & Phenotypes for Trigeminal Neuralgia

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Human phenotypes related to Trigeminal Neuralgia:

60 33 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 trigeminal neuralgia 60 33 obligate (100%) Obligate (100%) HP:0100661
2 depressivity 60 33 hallmark (90%) Very frequent (99-80%) HP:0000716
3 cluster headache 60 33 hallmark (90%) Very frequent (99-80%) HP:0012199
4 allodynia 60 33 hallmark (90%) Very frequent (99-80%) HP:0012533
5 feeding difficulties 60 33 frequent (33%) Frequent (79-30%) HP:0011968
6 paresthesia 60 33 frequent (33%) Frequent (79-30%) HP:0003401
7 sensory impairment 60 33 frequent (33%) Frequent (79-30%) HP:0003474
8 difficulty in tongue movements 60 33 frequent (33%) Frequent (79-30%) HP:0000183
9 poor speech 60 33 frequent (33%) Frequent (79-30%) HP:0002465
10 episodic paroxysmal anxiety 60 33 frequent (33%) Frequent (79-30%) HP:0000740
11 vascular tortuosity 60 33 frequent (33%) Frequent (79-30%) HP:0004948
12 mandibular pain 60 33 frequent (33%) Frequent (79-30%) HP:0200025
13 neoplasm 60 33 occasional (7.5%) Occasional (29-5%) HP:0002664
14 peripheral demyelination 60 33 occasional (7.5%) Occasional (29-5%) HP:0011096
15 ocular pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0200026
16 cranial nerve compression 60 33 occasional (7.5%) Occasional (29-5%) HP:0001293
17 cns demyelination 60 33 occasional (7.5%) Occasional (29-5%) HP:0007305
18 abnormality of the nervous system 33 HP:0000707

Symptoms via clinical synopsis from OMIM:

58
Neuro:
trigeminal neuralgia

Clinical features from OMIM:

190400

UMLS symptoms related to Trigeminal Neuralgia:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia, facial pain, atypical facial pain, orofacial pain

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 CRLF1 ESR1 JMJD6 MBD1 MSTN SCN10A
2 nervous system MP:0003631 9.5 CRLF1 ESR1 JMJD6 MBD1 SCN10A SCN9A
3 no phenotypic analysis MP:0003012 9.02 ESR1 JMJD6 MSTN SCN10A SCN3A
Sources

Drugs & Therapeutics for Trigeminal Neuralgia

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Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Ondansetron Approved Phase 4 99614-02-5 4595
3
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
4
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Not Applicable 1177-87-3
7
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 38396-39-3, 2180-92-9 2474
8
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
9
Artemether Approved Phase 4 71963-77-4 68911 119380
10
Lumefantrine Approved Phase 4 82186-77-4 6437380
11
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 51-84-3 187
12
Oxcarbazepine Approved Phase 4 28721-07-5 34312
13 Dermatologic Agents Phase 4,Not Applicable
14 Antipsychotic Agents Phase 4,Phase 2,Phase 3,Not Applicable
15 Analgesics, Opioid Phase 4
16 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
17 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
18 Serotonin Antagonists Phase 4
19 Excitatory Amino Acids Phase 4,Phase 2
20 Narcotics Phase 4
21 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
22 Excitatory Amino Acid Antagonists Phase 4,Phase 2
23 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Anesthetics, Intravenous Phase 4
25 Anesthetics, Dissociative Phase 4
26 Gastrointestinal Agents Phase 4
27 Antipruritics Phase 4
28 Antiemetics Phase 4
29 Tranquilizing Agents Phase 4,Phase 2,Phase 3,Not Applicable
30 Psychotropic Drugs Phase 4,Phase 2,Phase 3,Not Applicable
31 Autonomic Agents Phase 4
32 Anti-Anxiety Agents Phase 4
33 Adjuvants, Anesthesia Phase 4
34 Serotonin Agents Phase 4,Not Applicable
35 Anesthetics, General Phase 4
36 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
38 Triamcinolone hexacetonide Phase 4
39 BB 1101 Phase 4,Not Applicable
40 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
41 Anesthetics, Local Phase 4,Phase 2,Phase 3,Not Applicable
42 Anti-Inflammatory Agents Phase 4
43 Immunologic Factors Phase 4
44 HIV Protease Inhibitors Phase 4
45 Antineoplastic Agents, Hormonal Phase 4
46 Immunosuppressive Agents Phase 4
47 glucocorticoids Phase 4
48 Triamcinolone diacetate Phase 4
49
protease inhibitors Phase 4
50 triamcinolone acetonide Phase 4

Interventional clinical trials:

(show top 50) (show all 60)
# Name Status NCT ID Phase Drugs
1 Postoperative Analgesia in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
2 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
3 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain Completed NCT02024724 Phase 4 Bupivacaine;Triamcinolone;Dexamethasone
4 A Community Setting Study of Malaria After Systematic Treatment of Symptomatic Carriers of P. Falciparum With COA566 (Coartem®) Completed NCT01256658 Phase 4 COA566
5 (Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist Recruiting NCT03381261 Phase 4 Botulinum toxin type A
6 Oxtellar Extended Release (Oxcarbazepine Extended Release) Patients With Trigeminal Neuralgia Not yet recruiting NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
7 Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
8 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3 Levobupivacaine;Bupivacaine
9 Botulinum Toxin for Trigeminal Neuralgia Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
10 Botulinum Toxin Injections for Oral Neuropathic Pain Recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
11 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
12 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
13 A Study of Amifostine for Prevention of Facial Numbness in Radiosurgery Treatment of Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
14 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
15 Efficacy and Safety of ATNC05 in Treatment of Atypical Facial Pain Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
16 Clinical Trial of Hyperbaric Oxygen Treatment in Trigeminal Neuralgia Patients Unknown status NCT00866424 Phase 1, Phase 2
17 Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
18 A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
19 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
20 Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain Completed NCT00001725 Phase 2 Dextromethorphan
21 Trial for Treatment Refractory Trigeminal Neuralgia Recruiting NCT03941834 Phase 2 Rimegepant;Placebo
22 Efficacy of Guanfacine and Lidocaine Combination in Trigeminal Nerve Block for Pain Management in Trigeminal Neuropathy Not yet recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
23 Botulinum Toxin for the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
24 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Terminated NCT02624661 Phase 1, Phase 2 Glycerol
25 PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Completed NCT02359344 Phase 1 CNV1014802;Placebo
26 PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Completed NCT02831517 Phase 1 BIIB074;Placebo
27 New Formulation and Food Effect Study of BIIB074 Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
28 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
29 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
30 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630 Not Applicable
31 Magnetic Resonance Imaging Study on Patients With Trigeminal Neuralgia Unknown status NCT02713646
32 Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
33 Classical Trigeminal Neuralgia and Sodium Channel Mutations Completed NCT03656497
34 3D-CT-guided Percutaneous Radiofrequency Thermocoagulation for Tumor-related Trigeminal Neuralgia Completed NCT03549013
35 Prognosis of Trigeminal Neuralgia When Enrolled in a Multidisciplinary Management Program Completed NCT03838393
36 Treatment of Recurrent Trigeminal Neuralgia by Using Extended Duration of Pulsed Radiofrequency Completed NCT03396406 Not Applicable
37 A Nasal Applicator for the Treatment of Trigeminal Neuralgia Completed NCT01761604 Not Applicable
38 Research Study to Test Safety and Effectiveness of Investigational Drug in Patients With Trigeminal Neuralgia Completed NCT00203229 Not Applicable lamotrigine;Placebo
39 Randomized Study of L-Baclofen in Patients With Refractory Trigeminal Neuralgia Completed NCT00004431 Not Applicable L-baclofen
40 The Effect of Intravenous Lidocaine on Trigeminal Neuralgia Completed NCT01955967 Not Applicable Lidocaine
41 EEG Monitoring to Assess Emergence From Neuroanesthesia Completed NCT00443807 Not Applicable
42 Hippocampal Radiation Exposure and Memory Completed NCT00603694
43 A Study of Intra-dermal Injection of Botulinum Toxin Type A for the Diabetic Neuropathic Foot Pain Completed NCT00336349 Not Applicable Botulinum Toxin Type A
44 Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study Completed NCT03066037
45 Regional Anesthesia in Refractory Trigeminal Neuralgia: 21 Cases Reported to the Limoges University Hospital Recruiting NCT03669744
46 RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery Recruiting NCT02708810 Not Applicable
47 Neurophysiologic Signatures of Trigeminal Neuralgia Pain Recruiting NCT03778177 Not Applicable
48 High-voltage Pulsed Radiofrequency on Gasserian Ganglion to Treat Patients With Primary Trigeminal Neuralgia Recruiting NCT03131466 Not Applicable Nerve block
49 Phenytoin as Treatment for Acute Exacerbations of Trigeminal Neuralgia - a Prospective Systematic Study of 20 Patients Recruiting NCT03712254 Fosphenytoin
50 The Will Erwin Headache Research Center - Cluster Headache Study Recruiting NCT02910323

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: trigeminal neuralgia

Sources

Genetic Tests for Trigeminal Neuralgia

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Genetic tests related to Trigeminal Neuralgia:

# Genetic test Affiliating Genes
1 Trigeminal Neuralgia 30
Sources

Anatomical Context for Trigeminal Neuralgia

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MalaCards organs/tissues related to Trigeminal Neuralgia:

42
Brain, Testes, Trigeminal Ganglion, Tongue, Skin, Kidney, Cortex
Sources

Publications for Trigeminal Neuralgia

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Articles related to Trigeminal Neuralgia:

(show top 50) (show all 3103)
# Title Authors Year
1
Effects of depression and anxiety on microvascular decompression outcome for trigeminal neuralgia patients. ( 31071444 )
2019
2
Recurrent Secondary Trigeminal Neuralgia Caused by Obliterated Tentorial Dural Arteriovenous Fistula Cured with Surgical Resection: Case Report and Literature Review. ( 30176399 )
2019
3
Trigeminal Neuralgia Caused by Dural Arteriovenous Fistula in Meckel Cave Treated with Gamma Knife Radiosurgery. ( 30500585 )
2019
4
Course of Concomitant Bell's Palsy and Trigeminal Neuralgia Shortened with a Multi-Modal Intervention: A Case Report. ( 31104906 )
2019
5
Case Report: Repetitive Transcranial Magnetic Stimulation for Comorbid Treatment-Resistant Depression and Trigeminal Neuralgia. ( 30973457 )
2019
6
Diffuse Large B Cell Lymphoma Presented as Trigeminal Neuralgia: 2 Cases Reported and Literature Review. ( 30528527 )
2019
7
The Exacerbation of Hemicrania Continua Mimics Trigeminal Neuralgia. ( 30333409 )
2019
8
A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm. ( 30612530 )
2019
9
Revision Microvascular Decompression for Trigeminal Neuralgia and Hemifacial Spasm: Factors Associated with Surgical Failure. ( 30733898 )
2019
10
A Charcot Marie Tooth Type 1B Kindred Associated with Hemifacial Spasm and Trigeminal Neuralgia. ( 30920665 )
2019
11
Herpes Simplex Reactivation After Surgical Treatment of Trigeminal Neuralgia: A Retrospective Cohort Study. ( 30771541 )
2019
12
Percutaneous glycerol rhizotomy for trigeminal neuralgia in patients with multiple sclerosis: a long-term retrospective cohort study. ( 30978686 )
2019
13
Commentary: One Hundred Eleven Percutaneous Balloon Compressions for Trigeminal Neuralgia in a Cohort of 66 Patients with Multiple Sclerosis. ( 30919895 )
2019
14
The Effectiveness of Percutaneous Balloon Compression, Thermocoagulation, and Glycerol Rhizolysis for Trigeminal Neuralgia in Multiple Sclerosis. ( 30957177 )
2019
15
Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options. ( 30782116 )
2019
16
One hundred eleven Percutaneous Balloon Compressions for Trigeminal Neuralgia in a Cohort of 66 Patients with Multiple Sclerosis. ( 30690631 )
2019
17
Possible Prognostic Role of Magnetic Resonance Imaging Findings in Patients with Trigeminal Neuralgia and Multiple Sclerosis Who Underwent Percutaneous Balloon Compression: Report of Our Series and Literature Review. ( 30716488 )
2019
18
Stereotactic Radiosurgery for Trigeminal Neuralgia in Patients With Multiple Sclerosis: A Multicenter Study. ( 29688562 )
2019
19
Comparison of the Neuropathic Pain Symptoms and Psychosocial Impacts of Trigeminal Neuralgia and Painful Posttraumatic Trigeminal Neuropathy. ( 30703173 )
2019
20
Comparative Analysis of Balloon Compression and Radiofrequency Ablation in Idiopathic Trigeminal Neuralgia: A Retrospective Study with a 24-Month Follow-up. ( 31080957 )
2019
21
Radiosurgery for the management of intractable trigeminal neuralgia. ( 31085850 )
2019
22
Trigeminal neuralgia: An orphan with many fathers. ( 31085851 )
2019
23
The efficacy of gamma knife radiosurgery in patients with trigeminal neuralgia: The initial experience of the Bezmialem Vakif University. ( 31085863 )
2019
24
Altered brain network centrality in patients with trigeminal neuralgia: a resting-state fMRI study. ( 31088124 )
2019
25
Gamma knife radiosurgery for trigeminal neuralgia: first case series from Latin America. ( 31090803 )
2019
26
P2X receptors and trigeminal neuralgia. ( 31095112 )
2019
27
Trigeminal Neuralgia and Other Facial Neuralgias. ( 31096245 )
2019
28
Trigeminal Neuralgia Resulting from Delayed Cervical Cord Compression after Acute Traumatic Fracture of Odontoid Process. ( 31098348 )
2019
29
Risk of probable posttraumatic stress disorder in patients with trigeminal neuralgia. ( 30295062 )
2019
30
Dedicated Linear Accelerator Radiosurgery for Classic Trigeminal Neuralgia: A Single-Center Experience with Long-Term Follow-Up. ( 30312817 )
2019
31
Predicting the therapeutic effect of carbamazepine in trigeminal neuralgia by analysis of neurovascular compression utilizing magnetic resonance cisternography. ( 30316661 )
2019
32
Surgical Management of Trigeminal Neuralgia in Children. ( 30347302 )
2019
33
Familial Trigeminal Neuralgia Cases Implicate Genetic Factors in Disease Pathogenesis. ( 30398541 )
2019
34
Epidermoid Cyst of the Cerebellopontine Angle Presenting with Contralateral Trigeminal Neuralgia: Extremely Rare Case and Review of Literature. ( 30414520 )
2019
35
Analysis of morphological measurements of the trigeminal nerve in the linac stereotactic radiosurgery simulation targeting the root entry zone in trigeminal neuralgia. ( 30424930 )
2019
36
Long-term pain relief at five years after medical, repeat surgical procedures or no management for recurrence of trigeminal neuralgia after microvascular decompression: analysis of a historical cohort. ( 30451006 )
2019
37
Study on the Therapeutic Effects of Trigeminal Neuralgia With Microvascular Decompression and Stereotactic Gamma Knife Surgery in the Elderly. ( 30507874 )
2019
38
Evaluation of biochemical variables in patients with trigeminal neuralgia. ( 30527860 )
2019
39
The efficacy and safety of nerve combing for trigeminal neuralgia without neurovascular compression. ( 30838601 )
2019
40
Which drug treatments are best for trigeminal neuralgia? ( 30842102 )
2019
41
Retrosigmoid approach for glycerin rhizotomy in the treatment of trigeminal neuralgia without overt arterial compression: updated case series. ( 30849763 )
2019
42
A case of trigeminal neuralgia caused by both duplicated superior cerebellar arteries. ( 30860135 )
2019
43
European Academy of Neurology guideline on trigeminal neuralgia. ( 30860637 )
2019
44
Time course of pain response and toxicity after whole-nerve-encompassing LINAC-based stereotactic radiosurgery for trigeminal neuralgia-a prospective observational study. ( 30877350 )
2019
45
A Case of Ophthalmic Branch Trigeminal Neuralgia in the Emergency Department. ( 30891372 )
2019
46
Pain Outcomes Following Microvascular Decompression for Drug-Resistant Trigeminal Neuralgia: A Systematic Review and Meta-Analysis. ( 30892607 )
2019
47
Erratum. Endoscopic versus open microvascular decompression for trigeminal neuralgia: a systematic review and comparative meta-analysis. ( 30901749 )
2019
48
Letter to the Editor. Microvascular decompression for trigeminal neuralgia: does it matter whether the view is through a microscope or via an endoscope? ( 30901752 )
2019
49
Trigeminal neuralgia in vestibular schwannoma: Atypical presentation and neuroanatomical correlations. ( 30905383 )
2019
50
Vascular Offenders in Trigeminal Neuralgia: A Unified Classification and Assessment of the Outcome of Microvascular Decompression. ( 30905645 )
2019
Sources

Variations for Trigeminal Neuralgia

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Sources

Expression for Trigeminal Neuralgia

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Search GEO for disease gene expression data for Trigeminal Neuralgia.
Sources

Pathways for Trigeminal Neuralgia

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Pathways related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
L1CAM interactions 67
Show member pathways
 11.43 SCN10A SCN3A SCN9A
2
Phase 0 - rapid depolarisation 67
Show member pathways
 11.01 SCN10A SCN3A SCN9A
3
Interaction between L1 and Ankyrins 67
10.28 SCN10A SCN3A SCN9A
Sources

GO Terms for Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of presynaptic membrane GO:0099056 8.96 SCN10A SLC6A4
2 voltage-gated sodium channel complex GO:0001518 8.8 SCN10A SCN3A SCN9A

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.67 SCN10A SCN3A SCN9A SLC6A4
2 ion transmembrane transport GO:0034220 9.58 SCN10A SCN3A SCN9A
3 regulation of ion transmembrane transport GO:0034765 9.5 SCN10A SCN3A SCN9A
4 response to estrogen GO:0043627 9.46 ESR1 MSTN
5 sensory perception of pain GO:0019233 9.43 SCN10A SCN9A
6 sodium ion transport GO:0006814 9.43 SCN10A SCN3A SCN9A
7 sodium ion transmembrane transport GO:0035725 9.33 SCN10A SCN3A SCN9A
8 neuronal action potential GO:0019228 9.13 SCN10A SCN3A SCN9A
9 membrane depolarization during action potential GO:0086010 8.8 SCN10A SCN3A SCN9A

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.43 SCN10A SCN3A SCN9A
2 voltage-gated ion channel activity GO:0005244 9.33 SCN10A SCN3A SCN9A
3 sodium channel activity GO:0005272 9.13 SCN10A SCN3A SCN9A
4 voltage-gated sodium channel activity GO:0005248 8.8 SCN10A SCN3A SCN9A
Sources

Sources for Trigeminal Neuralgia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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