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MCID: TRG002
MIFTS: 60

Trigeminal Neuralgia

Categories: Blood diseases, Neuronal diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Trigeminal Neuralgia

About this section

MalaCards integrated aliases for Trigeminal Neuralgia:

Name: Trigeminal Neuralgia 56 12 74 52 53 58 29 54 42 43 15 17 71 32
Tic Douloureux 56 52 53
Trifacial Neuralgia 12
Trifocal Neuralgia 12

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant form


HPO:

31
trigeminal neuralgia:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Oral diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12098
OMIM 56 190400
ICD9CM 34 350.1
MeSH 43 D014277
SNOMED-CT 67 31681005
ICD10 32 G50.0
MESH via Orphanet 44 D014277
ICD10 via Orphanet 33 G50.0
UMLS via Orphanet 72 C0040997
Orphanet 58 ORPHA221091
MedGen 41 C0040997
UMLS 71 C0040997
Sources

Summaries for Trigeminal Neuralgia

About this section
NINDS : 53 Trigeminal neuralgia (TN), also called tic douloureux, is a chronic pain condition that causes extreme, sporadic, sudden burning or shock-like face pain. The pain seldom lasts more than a few seconds or a minute or two per episode. The intensity of pain can be physically and mentally incapacitating. TN pain is typically felt on one side of the jaw or cheek. Episodes can last for days, weeks, or months at a time and then disappear for months or years. In the days before an episode begins, some patients may experience a tingling or numbing sensation or a somewhat constant and aching pain. The attacks often worsen over time, with fewer and shorter pain-free periods before they recur. The intense flashes of pain can be triggered by vibration or contact with the cheek (such as when shaving, washing the face, or applying makeup), brushing teeth, eating, drinking, talking, or being exposed to the wind. TN occurs most often in people over age 50, but it can occur at any age, and is more common in women than in men. There is some evidence that the disorder runs in families, perhaps because of an inherited pattern of blood vessel formation. Although sometimes debilitating, the disorder is not life-threatening. The presumed cause of TN is a blood vessel pressing on the trigeminal nerve in the head as it exits the brainstem. TN may be part of the normal aging process but in some cases it is the associated with another disorder, such as multiple sclerosis or other disorders characterized by damage to the myelin sheath that covers certain nerves.

MalaCards based summary : Trigeminal Neuralgia, also known as tic douloureux, is related to glossopharyngeal neuralgia and arachnoiditis, and has symptoms including seizures, tremor and back pain. An important gene associated with Trigeminal Neuralgia is SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Ketamine and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include brain, trigeminal ganglion and testes, and related phenotypes are trigeminal neuralgia and depressivity

NIH Rare Diseases : 52 Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of the face), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.

MedlinePlus : 42 Trigeminal neuralgia (TN) is a type of chronic pain that affects your face. It causes extreme, sudden burning or shock-like pain. It usually affects one side of the face. Any vibration on your face, even from talking, can set it off. The condition may come and go, disappearing for days or even months. But the longer you have it, the less often it goes away. TN usually affects people over 50, especially women. The cause is probably a blood vessel pressing on the trigeminal nerve, one of the largest nerves in the head. Tumors and multiple sclerosis can also cause TN, but in some cases the cause is unknown. There is no specific test for TN. It can be hard to diagnose, since many other conditions can cause facial pain. Treatment options include medicines, surgery, and complementary techniques. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 Trigeminal neuralgia (TN or TGN) is a long-term pain disorder that affects the trigeminal nerve. There... more...

More information from OMIM: 190400
Sources

Related Diseases for Trigeminal Neuralgia

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Diseases related to Trigeminal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 448)
# Related Disease Score Top Affiliating Genes
1 glossopharyngeal neuralgia 33.4 TAC1 KANTR CRLF1
2 arachnoiditis 31.2 TAC1 CRLF1
3 facial neuralgia 31.1 TAC1 MBD1 CRLF1
4 cerebellopontine angle tumor 31.0 KANTR CRLF1
5 neuroma 31.0 TRPV1 SCN10A CALCA
6 intracranial hypotension 30.7 MBD1 CRLF1
7 diabetic neuropathy 30.5 TRPV1 SCN9A CALCA
8 postpartum depression 30.4 SLC6A4 LOC110806262 ESR1
9 algoneurodystrophy 30.2 TAC1 NPS CALCA
10 reflex sympathetic dystrophy 30.2 TAC1 NPS CALCA
11 causalgia 29.9 TRPV1 TAC1 NPS CALCA
12 myofascial pain syndrome 29.9 TRPV1 TAC1 NPS CALCA
13 vasomotor rhinitis 29.9 TRPV1 TAC1 NPS CALCA
14 major depressive disorder 29.8 TAC1 SLC6A4 OPRM1 NPS ESR1
15 sensory peripheral neuropathy 29.8 TRPV1 TRPA1 TAC1 CALCA
16 burning mouth syndrome 29.7 TRPV1 TAC1 SLC6A4 SCN9A P2RX3 CALCA
17 diarrhea 29.7 TRPV1 TAC1 SLC6A4 OPRM1 CALCA
18 anxiety 29.6 TAC1 SLC6A4 OPRM1 OPRL1 NPS ESR1
19 constipation 29.0 TRPV1 TAC1 SLC6A4 OPRM1 OPRL1 CALCA
20 pain agnosia 28.9 TRPV1 TRPA1 TAC1 SCN9A SCN10A OPRM1
21 migraine with aura 28.6 TAC1 SLC6A4 P2RX3 OPRM1 NPS LOC110806262
22 peripheral nervous system disease 28.0 TRPV1 TRPA1 TAC1 SCN9A SCN8A SCN3A
23 paine syndrome 27.6 TRPV1 TRPA1 TAC1 SCN9A SCN8A SCN3A
24 migraine with or without aura 1 27.1 TRPV1 TRPA1 TAC1 SLC6A4 SCN9A SCN8A
25 headache 11.8
26 sunct headache 11.8
27 trigeminal trophic syndrome 11.8
28 hemifacial atrophy, progressive 11.8
29 epidermoid brain cyst 11.5
30 hemifacial spasm, familial 10.9
31 hemifacial spasm 10.9
32 multiple sclerosis 10.8
33 persistent idiopathic facial pain 10.7
34 arteriovenous malformation 10.7
35 meningioma, radiation-induced 10.7
36 meningioma, familial 10.7
37 spinal meningioma 10.7
38 secretory meningioma 10.7
39 lymphoplasmacyte-rich meningioma 10.7
40 chronic pain 10.7
41 paresthesia 10.7
42 keratitis, hereditary 10.6
43 facial paralysis 10.6
44 cluster headache 10.6
45 hydrocephalus 10.6
46 neurilemmoma 10.5
47 acoustic neuroma 10.5
48 herpes simplex 10.5
49 postherpetic neuralgia 10.5
50 cranial neuralgia 10.5

Comorbidity relations with Trigeminal Neuralgia via Phenotypic Disease Network (PDN):


Acute Cystitis Glossopharyngeal Neuralgia
Hypertension, Essential Hypothyroidism
Multiple Sclerosis

Graphical network of the top 20 diseases related to Trigeminal Neuralgia:



Diseases related to Trigeminal Neuralgia
Sources

Symptoms & Phenotypes for Trigeminal Neuralgia

About this section

Human phenotypes related to Trigeminal Neuralgia:

58 31 (show all 18)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 trigeminal neuralgia 58 31 obligate (100%) Obligate (100%) HP:0100661
2 depressivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0000716
3 allodynia 58 31 hallmark (90%) Very frequent (99-80%) HP:0012533
4 cluster headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0012199
5 feeding difficulties 58 31 frequent (33%) Frequent (79-30%) HP:0011968
6 paresthesia 58 31 frequent (33%) Frequent (79-30%) HP:0003401
7 sensory impairment 58 31 frequent (33%) Frequent (79-30%) HP:0003474
8 poor speech 58 31 frequent (33%) Frequent (79-30%) HP:0002465
9 mandibular pain 58 31 frequent (33%) Frequent (79-30%) HP:0200025
10 episodic paroxysmal anxiety 58 31 frequent (33%) Frequent (79-30%) HP:0000740
11 difficulty in tongue movements 58 31 frequent (33%) Frequent (79-30%) HP:0000183
12 vascular tortuosity 58 31 frequent (33%) Frequent (79-30%) HP:0004948
13 neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0002664
14 ocular pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0200026
15 peripheral demyelination 58 31 occasional (7.5%) Occasional (29-5%) HP:0011096
16 cns demyelination 58 31 occasional (7.5%) Occasional (29-5%) HP:0007305
17 cranial nerve compression 58 31 occasional (7.5%) Occasional (29-5%) HP:0001293
18 abnormality of the nervous system 31 HP:0000707

Symptoms via clinical synopsis from OMIM:

56
Neuro:
trigeminal neuralgia

Clinical features from OMIM:

190400

UMLS symptoms related to Trigeminal Neuralgia:


seizures, tremor, back pain, headache, syncope, pain, chronic pain, sciatica, vertigo/dizziness, sleeplessness, neuralgia, facial pain, atypical facial pain, orofacial pain

MGI Mouse Phenotypes related to Trigeminal Neuralgia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 CRLF1 ESR1 MBD1 OPRL1 OPRM1 P2RX3
2 integument MP:0010771 9.9 ESR1 OPRL1 OPRM1 P2RX3 SCN10A SCN11A
3 nervous system MP:0003631 9.77 CRLF1 ESR1 MBD1 OPRL1 OPRM1 P2RX3
4 normal MP:0002873 9.23 ESR1 OPRL1 OPRM1 SCN3A SCN9A SLC6A4
Sources

Drugs & Therapeutics for Trigeminal Neuralgia

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Drugs for Trigeminal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
2
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
3
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
4
Ondansetron Approved Phase 4 99614-02-5 4595
5
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
6
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
7
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
10
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
11
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
12
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
13
Lumefantrine Approved Phase 4 82186-77-4 6437380
14
Artemether Approved Phase 4 71963-77-4 68911 9796294 119380
15 Anesthetics, Dissociative Phase 4
16 Anesthetics, General Phase 4
17 Anesthetics, Intravenous Phase 4
18 Analgesics Phase 4
19 triamcinolone acetonide Phase 4
20 Triamcinolone diacetate Phase 4
21 Triamcinolone hexacetonide Phase 4
22 Hormones Phase 4
23 Psychotropic Drugs Phase 4
24 Calcium, Dietary Phase 4
25 Antipsychotic Agents Phase 4
26 calcium channel blockers Phase 4
27 Excitatory Amino Acid Antagonists Phase 4
28 Anti-Anxiety Agents Phase 4
29 Antiemetics Phase 4
30 Gastrointestinal Agents Phase 4
31 Analgesics, Non-Narcotic Phase 4
32 Antineoplastic Agents, Hormonal Phase 4
33 Hormone Antagonists Phase 4
34 glucocorticoids Phase 4
35 Anti-Inflammatory Agents Phase 4
36 Antiparasitic Agents Phase 4
37 Antiprotozoal Agents Phase 4
38 Artemether, Lumefantrine Drug Combination Phase 4
39 Antimalarials Phase 4
40 Immunoglobulins Phase 4
41 Antibodies Phase 4
42 Antibodies, Blocking Phase 4
43
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
44
Calcium Nutraceutical Phase 4 7440-70-2 271
45
Bupivacaine Approved, Investigational Phase 2, Phase 3 2180-92-9, 38396-39-3 2474
46
4-Aminopyridine Approved Phase 2, Phase 3 504-24-5 1727
47
Levobupivacaine Approved, Investigational Phase 2, Phase 3 27262-47-1 92253
48
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
49 Anesthetics Phase 2, Phase 3
50 Anesthetics, Local Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 92)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Multimodal Analgesia Used in Patients With Microvascular Decompression Unknown status NCT03152955 Phase 4 Ketamine;ondansetron;Sufentanil
2 Examining the Efficacy of Low Intensity Low Frequency Surface Acoustic Wave Ultrasound(LILF/SAWU) in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
3 Randomised, Placebo Controlled, Double Blind, Parallel Group 3-Months Study of Carbamazepine Efficacy in Moderate Persistent and Severe Asthma Therapy Completed NCT00153296 Phase 4 Carbamazepine
4 Randomised, Placebo Controlled, Double Blind, Parallel Group 3-Months Study of Gabapentin Efficacy in Asthma Therapy Completed NCT00153283 Phase 4 Gabapentin
5 Randomised, Placebo Controlled, Double Blind, Parallel Group 3-Months Study of Sodium Valproate Efficacy in Asthma Therapy Completed NCT00153270 Phase 4 Sodium Valproate
6 Randomised, Placebo Controlled, Double Blind, Parallel Group 3-Months Study of Lamotrigine Efficacy in Asthma Therapy Completed NCT00153244 Phase 4 Lamotrigine
7 Randomised, Placebo Controlled, Double Blind, Parallel Group 3-Months Study of Oxcarbazepine Efficacy in Asthma Therapy Completed NCT00142025 Phase 4 Oxcarbazepine
8 Randomised, Placebo Controlled, Double Blind, Parallel Group 3-Months Study of Phenytoin Efficacy in Children for Therapy of Bronchial Asthma Completed NCT00366067 Phase 4 Phenytoin
9 A Cluster Randomized, Single-centre, Controlled, Parallel,12-month Prospective Study and Additional 12-month Follow-up in Africa of Malaria Incidence in a Community Setting Following Systematic Treatment of P. Falciparum Asymptomatic Carriers With Artemether-lumefantrine (Coartem® / Coartem® Dispersible) Completed NCT01256658 Phase 4 COA566
10 Phase 4 Study Comparing of Dexamethasone to Triamcinolone for Ultrasound-guided Trigeminal Nerve Block: A Randomized Controlled Trial. Completed NCT02024724 Phase 4 Bupivacaine;Triamcinolone;Dexamethasone
11 Randomised, Placebo Controlled, Double Blind, Parallel Group 3-Months Study of Phenytoin Efficacy in Bronchial Asthma Therapy Completed NCT00327028 Phase 4 Diphenine
12 Randomized, Placebo Controlled, Double Blind Study of Carbamazepine in Treatment of Bronchial Asthma Completed NCT00207428 Phase 4 Carbamazepine
13 Novel Concepts for OnabotulinumtoxinA (Botox) Mechanisms of Action: Role in Altering the Molecular Environment in Which Pain Fibers Exist Recruiting NCT03381261 Phase 4 Botulinum toxin type A
14 Anti-CGRP Neutralizing Antibody for Modulation of Neurogenic Inflammation in Trigeminal and Glossopharyngeal Pain Associated With Small Fiber Neuropathy/Fibromyalgia Suspended NCT04158752 Phase 4 Galcanezumab
15 Pilot Study of Oxtellar XR (Oxcarbazepine Extended Release) in Neurology Patients With Trigeminal Neuralgia Withdrawn NCT03374709 Phase 4 Oxtellar XR 150Mg Extended Release Tablet
16 Lamotrigine in Trigeminal Neuralgia: Efficacy and Safety in Comparison With Carbamazepine Completed NCT00913107 Phase 2, Phase 3 Lamictal®;Tegretol®
17 Effects of Dalfampridine on Cognition in Multiple Sclerosis Completed NCT02006160 Phase 2, Phase 3 dalfampridine;placebo
18 Comparative Study Between Levobupivacaine and Bupivacaine for Nerve Block During Pediatric Primary Cleft Palate Surgery Completed NCT02923869 Phase 2, Phase 3 Levobupivacaine;Bupivacaine
19 Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients Victims of Landmines With Phantom Limb Pain Completed NCT01872481 Phase 3
20 The Efficacy and Safety of Botulinum Toxin for the Treatment of Trigeminal Neuralgia: Comparison of Two Different Treatment Methods Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
21 Use of Botulinum Toxin (BTX) for the Treatment of Peripheral Painful Traumatic Trigeminal Neuropathy (PPTTN) Recruiting NCT03555916 Phase 3 BOTOX®, Allergan;Placebo
22 A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia Not yet recruiting NCT03637387 Phase 3 BIIB074;Placebo
23 A Phase 3 Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Efficacy and Safety of BIIB074 in Subjects With Trigeminal Neuralgia Not yet recruiting NCT03070132 Phase 3 BIIB074;Placebo
24 A Randomized, Placebo-controlled Trial of Amifostine for Prevention of Facial Numbness in Patients Receiving Stereotactic Radiosurgery for Trigeminal Neuralgia Terminated NCT01364259 Phase 3 Amifostine
25 Phase II Double Blind, Randomized, Placebo Controlled, Safety and Efficacy Study of ATNC05 in Patients With Atypical Facial Pain With an Open-Label Extension Phase for Nonresponders Withdrawn NCT01920087 Phase 2, Phase 3 ATNC05;Placebo
26 Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception Withdrawn NCT00349050 Phase 2, Phase 3
27 A Prospective Study on Efficacy of Hyperbaric Oxygenation Treatment for Patients With Trigeminal Neuralgia: a Randomized, Double-Blind, Mock Hyperbaric Chamber -Controlled, Parallel-Group Trial Unknown status NCT00866424 Phase 1, Phase 2
28 A Placebo-Controlled, Single-Blind Study Evaluating the Safety and Efficacy of Nasal Carbon Dioxide for the Symptomatic Treatment of Classical Trigeminal Neuralgia Completed NCT02473016 Phase 2 Carbon Dioxide Drug Delivery System (CDDS)
29 Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues. Completed NCT02662972 Phase 1, Phase 2 Botulinum Toxin Type A
30 A Phase IIa Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Safety and Efficacy of CNV1014802 in Patients With Trigeminal Neuralgia Completed NCT01540630 Phase 2 CNV1014802;Placebo
31 Effect of Pregabalin in Patients With Radiotherapy-Related Neuropathic Pain: a Randomized, Double-blind, Placebo-controlled Trial Completed NCT01869569 Phase 2 Pregabalin;Placebo
32 Clinical Trials in Orofacial Neuralgias Completed NCT00001725 Phase 2 Dextromethorphan
33 A Placebo-Controlled, Double-Blind, Randomized, Proof-of-Concept Study to Evaluate the Efficacy and Tolerability of Erenumab in Patients With Trigeminal Neuralgia Recruiting NCT04054024 Phase 2 Erenumab;Placebos
34 BHV3000-202: Phase 2: A Double-Blind, Placebo Controlled, Crossover Trial of BHV-3000 (Rimegepant) for Treatment Refractory Trigeminal Neuraligia Recruiting NCT03941834 Phase 2 Rimegepant;Placebo
35 A Randomized, Double-Blind, 2-Way Crossover Trial to Assess the Efficacy of Guanfacine and Lidocaine Combination Versus Lidocaine Alone in Trigeminal Nerve Block for Pain Management in Painful Trigeminal Neuropathy Patients Recruiting NCT03865940 Phase 2 Lidocaine;Guanfacine
36 A Multicenter Double Blinded Randomized Controlled Trial of the Efficacy of the Sphenopalatine Ganglion Block for the Treatment of the Postdural Puncture Headache After Labor Epidural Enrolling by invitation NCT03560349 Phase 2 Lidocaine HCl Gel 2%;placebo gel
37 Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy Not yet recruiting NCT03571334 Phase 2 IncobotulinumtoxinA (Xeomin®, Merz) (INA);Normal saline
38 Glycerol Block of the Trigeminal Ganglion in Trigeminal Neuralgia Using a New Neuronavigation-based Surgical Technique Terminated NCT02624661 Phase 1, Phase 2 Glycerol
39 A Randomized, Double-Blind, Placebo-Controlled, Add-on Therapy Study of Xeomin (Incobotulinumtoxina) Versus Placebo in the Treatment of Trigeminal Neuralgia Terminated NCT02088632 Phase 2
40 A Randomized, Double-blind, Placebo Controlled, Two Period Crossover Study to Investigate the Pharmacokinetics, Tolerability and Cognitive Effects of an Oral Dose Regimen of 150mg Tid CNV1014802 in Healthy Young Versus Elderly Male and Female Subjects Completed NCT02359344 Phase 1 CNV1014802;Placebo
41 A Phase 1, Open-label Study to Evaluate the Relative Bioavailability of Two Formulations of BIIB074 and to Assess the Effect of Food on BIIB074 Pharmacokinetics in Healthy Subjects Completed NCT02951221 Phase 1 BIIB074 Treatment A;BIIB074 Treatment B;BIIB074 Treatment C;BIIB074 Treatment D
42 A Phase 1 Pharmacokinetics and Safety Study of BIIB074 in Healthy Japanese and Caucasian Subjects Completed NCT02831517 Phase 1 BIIB074;Placebo
43 Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache Not yet recruiting NCT04353505 Phase 1 Ketorolac;Dexamethasone
44 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
45 Investigation of Diffusion Tensor Imaging Magnetic Resonance Imaging (DTI MRI) as a Correlate to Pain Relief and Facial Numbness in Patients Following Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364272
46 A Study of Patient Reported Outcomes After Stereotactic Radiosurgical Rhizotomy for Trigeminal Neuralgia Unknown status NCT01364285
47 An Evaluation of the Effect of a Surface Acoustic Wave Patch Device on the Symptons of Trigeminal Neuralgia Unknown status NCT02801630
48 Brain Activity Assessment by Functional MRI Before, After Radiofrequency of Gasserian Ganglia in Patient With Trigeminal Neuralgia Unknown status NCT03305289
49 Applied Research on Patients With Trigeminal Neuralgia by Multi-planar Reconstruction, Curved Planar Reconstruction and Magnetic Resonance Virtual Endoscopy Unknown status NCT02713646
50 Transitional Care Services: A Quality and Safety Process Improvement Programme in Neurosurgery Unknown status NCT03593330

Search NIH Clinical Center for Trigeminal Neuralgia

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Baclofen
Carbamazepine
tizanidine
tizanidine hydrochloride
Tocainide
Tocainide Monohydrochloride

Cochrane evidence based reviews: trigeminal neuralgia

Sources

Genetic Tests for Trigeminal Neuralgia

About this section

Genetic tests related to Trigeminal Neuralgia:

# Genetic test Affiliating Genes
1 Trigeminal Neuralgia 29
Sources

Anatomical Context for Trigeminal Neuralgia

About this section

MalaCards organs/tissues related to Trigeminal Neuralgia:

40
Brain, Trigeminal Ganglion, Testes, Skin, Bone, Cortex, Tongue
Sources

Publications for Trigeminal Neuralgia

About this section

Articles related to Trigeminal Neuralgia:

(show top 50) (show all 6198)
# Title Authors PMID Year
1
Familial trigeminal neuralgia: case report. 56 61
2716987 1989
2
Familial trigeminal neuralgia. 61 56
7387447 1980
3
Inherited tic douloureux. 61 56
4737685 1973
4
TRIGEMINAL NEURALGIA IN SIX MEMBERS OF ONE GENERATION. 56 61
14315671 1965
5
[Trigeminal neuralgia in three brothers of which two were twins]. 56 61
13794177 1959
6
Orofacial pain secondary to acoustic neuroma-A case report. 42 61
32384226 2020
7
Electroacupuncture therapy for change of pain in classical trigeminal neuralgia. 42 61
32311955 2020
8
Idiopathic Trigeminal Neuralgia (ITN): Facts and Fiction. 61 42
32160164 2019
9
BILATERAL TRIGEMINAL TIC: ITS ASSOCIATION WITH HEREDITY AND DISSEMINATED SCLEROSIS. 56
17856710 1936
10
Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. 54 61
11642720 2001
11
Transcriptional mRNA of bone morphogenetic proteins 2, 3, 4, and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. 54 61
11411255 2001
12
Hypertrophic Interstitial Neuropathy of the Trigeminal Nerve: Case Report and Literature Review. 61
31620786 2020
13
Development and Evaluation of a Preoperative Trigeminal Neuralgia Scoring System to Predict Long-Term Outcome Following Microvascular Decompression. 61
31541255 2020
14
Commentary: Development and Evaluation of a Preoperative Trigeminal Neuralgia Scoring System to Predict Long-Term Outcome Following Microvascular Decompression. 61
31625571 2020
15
Commentary: Development and Evaluation of a Preoperative Trigeminal Neuralgia Scoring System to Predict Long-Term Outcome Following Microvascular Decompression. 61
31813971 2020
16
Commentary: Vascular Transposition of the Superior Cerebellar Artery Using a Fenestrated Clip and Fibrin Glue in Trigeminal Neuralgia: 2-Dimensional Operative Video. 61
31724730 2020
17
Vascular Transposition of the Superior Cerebellar Artery Using a Fenestrated Clip and Fibrin Glue in Trigeminal Neuralgia: 2-Dimensional Operative Video. 61
31724733 2020
18
In Reply: Vascular Transposition of the Superior Cerebellar Artery Using a Fenestrated Clip and Fibrin Glue in Trigeminal Neuralgia: 2-Dimensional Operative Video. 61
32294210 2020
19
Letter: Vascular Transposition of the Superior Cerebellar Artery Using a Fenestrated Clip and Fibrin Glue in Trigeminal Neuralgia: 2-Dimensional Operative Video. 61
32297638 2020
20
Complication Rates During Endoscopic Microvascular Decompression Surgery Are Low With or Without Petrosal Vein Sacrifice. 61
32145425 2020
21
Neuropathy mimicking dental pain on a patient diagnosed with Lyme disease. 61
32562700 2020
22
Neurological manifestations of Behçet's disease: Study of 57 patients. 61
31924326 2020
23
Imaging Of Orofacial Pain. 61
32531821 2020
24
Current application of cannabidiol (CBD) in the management and treatment of neurological disorders. 61
32556748 2020
25
Effectiveness of Gamma Knife Radiosurgery in the Treatment of Refractory Trigeminal Neuralgia: A Case Series. 61
31620790 2020
26
The historical evolution of microvascular decompression for trigeminal neuralgia: from Dandy's discovery to Jannetta's legacy. 61
32519161 2020
27
Trigeminal Neuralgia Due to Compression of Primitive Trigeminal Artery Variant: Usefulness of Fusion Images of Constructive Interference in Steady-State Magnetic Resonance Imaging and Computed Tomography Angiography. 61
32151772 2020
28
3-dimensional computer graphics model elucidating involvement of intraparenchymal venous malformation in trigeminal nucleus of brachium pontis with intractable trigeminal neuralgia. 61
32291239 2020
29
Herbal medicine for the management of idiopathic trigeminal neuralgia: A protocol for a systematic review of controlled trials. 61
32569221 2020
30
Increased CSF levels of apolipoproteins and complement factors in trigeminal neuralgia patients - in depth proteomic analysis using mass spectrometry. 61
32553624 2020
31
The applicability and efficacy of magnetic resonance-guided high intensity focused ultrasound system in the treatment of primary trigeminal neuralgia. 61
32240878 2020
32
Trigeminal neuralgia linked to demyelination in multiple sclerosis. 61
32246109 2020
33
Clinical Analysis of Patients with Ipsilateral Coexistence of Hemifacial Spasm and Trigeminal Neuralgia. 61
32179189 2020
34
A Unique Case of Microvascular Triple Decompression for Combined Simultaneous Trigeminal Neuralgia, Hemifacial Spasm, and Glossopharyngeal Neuralgia Because of the Dolichoectatic Vertebrobasilar System. 61
31334555 2020
35
Aberrant Abducent Nerve During Microvascular Decompression for Trigeminal Neuralgiass. 61
32251825 2020
36
Acupuncture in the management of trigeminal neuralgia. 61
32517481 2020
37
Advancement in Neuromodulation Technology with the Innovation of Design-Specific Peripheral Nerve Stimulators: Sural Nerve Stimulation for Radiculopathy. 61
32249315 2020
38
IL-6 contributes to Nav1.3 up-regulation in trigeminal nerve following chronic constriction injury. 61
32279611 2020
39
The Effect of Atropine on Trigeminocardiac Reflex-induced Hemodynamic Changes During Therapeutic Compression of the Trigeminal Ganglion. 61
32496449 2020
40
Botulinum neurotoxin injections for muscle-based (dystonia and spasticity) and non-muscle-based (neuropathic pain) pain disorders: a meta-analytic study. 61
32146504 2020
41
Computed Tomography-Guided Radiofrequency Thermocoagulation of the Gasserian Ganglion Using an Alternative to Hartel Anterior Approach: A Bicentral Study. 61
32517395 2020
42
Intraoperative CT for Neuronavigation Guidance and Confirmation of Foramen Ovale Cannulation for Glycerol Trigeminal Rhizotomy: A Technical Report and Case Series. 61
32542155 2020
43
Facial Sensory Restoration After Trigeminal Sensory Rhizotomy by Collateral Sprouting From the Occipital Nerves. 61
31432075 2020
44
Vagus Associated Neurogenic Cough Occurring Due to Unilateral Vascular Encroachment of Its Root: A Case Report and Proof of Concept of VANCOUVER Syndrome. 61
31786948 2020
45
Anosmia and Ageusia as the Only Indicators of Coronavirus Disease 2019 (COVID-19). 61
32494532 2020
46
Palmatine alleviates hyperalgesia by inhibiting the expression of calcitonin gene-related peptide in the trigeminal ganglion of rats with chronic constriction injury of the infraorbital nerve. 61
32139146 2020
47
Outcomes of Treatment for Elderly Patients With Trigeminal Neuralgia: Percutaneous Balloon Compression Versus Microvascular Decompression. 61
32472880 2020
48
Factors affecting outcome in frameless non-isocentric stereotactic radiosurgery for trigeminal neuralgia: a multicentric cohort study. 61
32443978 2020
49
Intracranial Leiomyoma Associated with Epstein-Barr Virus: a cerebellopontine angle mass presenting with trigeminal neuralgia. 61
32450307 2020
50
Resection of the suprameatal tubercle in microvascular decompression for trigeminal neuralgia. 61
31993750 2020
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Variations for Trigeminal Neuralgia

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Expression for Trigeminal Neuralgia

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Search GEO for disease gene expression data for Trigeminal Neuralgia.
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Pathways for Trigeminal Neuralgia

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Pathways related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cardiac conduction 65
Show member pathways
 12.49 SCN9A SCN8A SCN3A SCN11A SCN10A
2
Neuropathic Pain-Signaling in Dorsal Horn Neurons 63
Show member pathways
 12.39 TAC1 SCN9A SCN8A SCN3A SCN11A SCN10A
3
Neuroscience 4
12.27 SCN9A SCN8A SCN11A SCN10A OPRM1 CALCA
4
Taste transduction 36
Show member pathways
 11.67 SCN9A SCN3A P2RX3
5
L1CAM interactions 65
Show member pathways
 11.65 SCN9A SCN8A SCN3A SCN11A SCN10A
6
Phase 0 - rapid depolarisation 65
Show member pathways
 11.23 SCN9A SCN8A SCN3A SCN11A SCN10A
7
Interaction between L1 and Ankyrins 65
10.5 SCN9A SCN8A SCN3A SCN11A SCN10A
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GO Terms for Trigeminal Neuralgia

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Cellular components related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.22 TRPV1 TRPA1 SLC6A4 SCN9A SCN8A SCN3A
2 plasma membrane GO:0005886 10.18 TRPV1 TRPA1 TAC1 SLC6A4 SCN9A SCN8A
3 integral component of plasma membrane GO:0005887 9.98 TRPV1 TRPA1 SLC6A4 SCN9A P2RX3 OPRM1
4 cell GO:0005623 9.87 TRPV1 TRPA1 TAC1 P2RX3 OPRL1 ESR1
5 neuron projection GO:0043005 9.7 TRPV1 SLC6A4 SCN9A P2RX3 OPRM1 OPRL1
6 axon GO:0030424 9.61 TAC1 SCN9A SCN8A SCN3A SCN11A SCN10A
7 integral component of presynaptic membrane GO:0099056 9.56 SLC6A4 SCN10A P2RX3 OPRM1
8 voltage-gated sodium channel complex GO:0001518 9.02 SCN9A SCN8A SCN3A SCN11A SCN10A

Biological processes related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.06 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN11A
2 transmembrane transport GO:0055085 10.01 TRPV1 TRPA1 SLC6A4 SCN9A SCN8A SCN3A
3 response to drug GO:0042493 9.96 TRPA1 SLC6A4 SCN11A MBD1
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.9 TRPV1 TAC1 ESR1 CALCA
5 regulation of ion transmembrane transport GO:0034765 9.89 SCN9A SCN8A SCN3A SCN11A SCN10A
6 sodium ion transport GO:0006814 9.88 SCN9A SCN8A SCN3A SCN11A SCN10A
7 ion transmembrane transport GO:0034220 9.87 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN10A
8 response to estradiol GO:0032355 9.85 SLC6A4 OPRL1 MBD1 ESR1
9 calcium ion transmembrane transport GO:0070588 9.84 TRPV1 TRPA1 OPRM1
10 neuropeptide signaling pathway GO:0007218 9.83 TAC1 OPRM1 OPRL1 NPS CALCA
11 response to organic substance GO:0010033 9.82 TRPA1 SLC6A4 P2RX3
12 excitatory postsynaptic potential GO:0060079 9.8 TRPV1 P2RX3 OPRM1
13 response to heat GO:0009408 9.77 TRPV1 P2RX3 CALCA
14 sodium ion transmembrane transport GO:0035725 9.77 SCN9A SCN8A SCN3A SCN11A SCN10A
15 cellular response to nerve growth factor stimulus GO:1990090 9.76 TRPV1 TAC1 CALCA
16 regulation of sensory perception of pain GO:0051930 9.73 SCN11A OPRM1 OPRL1
17 behavioral response to pain GO:0048266 9.7 TRPV1 SCN9A P2RX3
18 sensory perception GO:0007600 9.69 SCN10A OPRM1 OPRL1
19 cellular response to ATP GO:0071318 9.66 TRPV1 P2RX3
20 estrous cycle GO:0044849 9.66 OPRM1 OPRL1
21 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.65 TRPV1 CALCA
22 positive regulation of synaptic transmission, GABAergic GO:0032230 9.64 TAC1 NPS
23 negative regulation of heart rate GO:0010459 9.64 TRPV1 TAC1
24 opioid receptor signaling pathway GO:0038003 9.63 OPRM1 OPRL1
25 positive regulation of sensory perception of pain GO:1904058 9.62 P2RX3 OPRL1
26 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106072 9.62 OPRM1 OPRL1
27 urinary bladder smooth muscle contraction GO:0014832 9.61 TRPV1 P2RX3
28 positive regulation of action potential GO:0045760 9.61 TAC1 NPS
29 detection of chemical stimulus involved in sensory perception of pain GO:0050968 9.58 TRPV1 TRPA1
30 thermoception GO:0050955 9.57 TRPV1 TRPA1
31 response to pain GO:0048265 9.56 TRPV1 TRPA1 TAC1 CALCA
32 membrane depolarization during action potential GO:0086010 9.55 SCN9A SCN8A SCN3A SCN11A SCN10A
33 positive regulation of gastric acid secretion GO:0060454 9.54 TRPV1 OPRL1
34 neuronal action potential GO:0019228 9.43 SCN9A SCN8A SCN3A SCN11A SCN10A P2RX3
35 sensory perception of pain GO:0019233 9.17 TRPV1 TRPA1 TAC1 SCN9A SCN10A OPRM1

Molecular functions related to Trigeminal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.98 TRPV1 TRPA1 SLC6A4 P2RX3 ESR1 CALCA
2 voltage-gated ion channel activity GO:0005244 9.72 SCN9A SCN8A SCN3A SCN11A SCN10A
3 sodium channel activity GO:0005272 9.65 SCN9A SCN8A SCN3A SCN11A SCN10A
4 voltage-gated sodium channel activity GO:0005248 9.55 SCN9A SCN8A SCN3A SCN11A SCN10A
5 cation channel activity GO:0005261 9.43 TRPV1 SCN9A SCN8A SCN3A SCN11A SCN10A
6 calcium-release channel activity GO:0015278 9.4 TRPV1 TRPA1
7 opioid receptor activity GO:0004985 9.37 OPRM1 OPRL1
8 ion channel activity GO:0005216 9.23 TRPV1 TRPA1 SCN9A SCN8A SCN3A SCN11A
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Sources for Trigeminal Neuralgia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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