MCID: TRG001
MIFTS: 37

Trigonitis

Categories: Nephrological diseases

Aliases & Classifications for Trigonitis

MalaCards integrated aliases for Trigonitis:

Name: Trigonitis 12 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:13507
ICD9CM 34 595.3
NCIt 50 C123175
SNOMED-CT 67 155885003
ICD10 32 N30.3
UMLS 70 C1261278

Summaries for Trigonitis

MalaCards based summary : Trigonitis is related to acute cystitis and interstitial cystitis. An important gene associated with Trigonitis is PGR (Progesterone Receptor), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Mepivacaine and Hormones have been mentioned in the context of this disorder. Affiliated tissues include breast, cervix and spinal cord, and related phenotype is homeostasis/metabolism.

Wikipedia : 73 Trigonitis is a condition of inflammation of the trigone region of the bladder. It is more common in... more...

Related Diseases for Trigonitis

Diseases related to Trigonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 acute cystitis 29.4 SLC5A4 SLC5A2 SLC5A1 DPP4
2 interstitial cystitis 11.1
3 glassy cell carcinoma of the cervix 10.4 PGR ESR1
4 breast intraductal papillomatosis 10.4 PGR ESR1
5 intraductal papilloma 10.4 PGR ESR1
6 nipple carcinoma 10.4 PGR ESR1
7 bartholin's gland adenoma 10.4 PGR ESR1
8 bartholin's gland adenoid cystic carcinoma 10.4 PGR ESR1
9 uterine corpus adenosarcoma 10.4 PGR ESR1
10 bartholin's gland benign neoplasm 10.4 PGR ESR1
11 chronic tympanitis 10.4 PGR ESR1
12 vestibular gland benign neoplasm 10.4 PGR ESR1
13 granulomatous endometritis 10.4 PGR ESR1
14 vulvar syringoma 10.4 PGR ESR1
15 lung leiomyoma 10.4 PGR ESR1
16 adult type testicular granulosa cell tumor 10.4 PGR ESR1
17 breast scirrhous carcinoma 10.4 PGR ESR1
18 oncocytic breast carcinoma 10.4 PGR ESR1
19 cervical clear cell adenocarcinoma 10.4 PGR ESR1
20 ovarian seromucinous carcinoma 10.4 PGR ESR1
21 breast papillary carcinoma 10.4 PGR ESR1
22 comedo carcinoma 10.4 PGR ESR1
23 breast adenoid cystic carcinoma 10.4 PGR ESR1
24 breast leiomyoma 10.4 PGR CD34
25 breast metaplastic carcinoma 10.4 PGR ESR1
26 intracranial meningioma 10.4 PGR ESR1
27 pulmonary vein leiomyosarcoma 10.4 PGR CD34
28 lung meningioma 10.4 PGR CD34
29 mucocele of appendix 10.4 PGR CD34
30 bizarre leiomyoma 10.4 PGR ESR1
31 breast adenoma 10.4 PGR ESR1
32 breast myofibroblastoma 10.4 ESR1 CD34
33 peritoneal benign neoplasm 10.4 PGR CD34
34 lipid-rich carcinoma 10.4 PGR ESR1
35 prostate sarcoma 10.4 PGR CD34
36 progesterone-receptor negative breast cancer 10.4 PGR ESR1
37 cervical polyp 10.4 PGR CD34
38 intracystic papillary adenoma 10.4 PGR ESR1
39 breast osteosarcoma 10.3 PGR ESR1
40 urethral benign neoplasm 10.3 PGR ESR1
41 vaginal endometrial stromal sarcoma 10.3 PGR CD34
42 apocrine sweat gland neoplasm 10.3 PGR ESR1
43 apocrine adenocarcinoma 10.3 PGR ESR1
44 pleomorphic lipoma 10.3 PGR CD34
45 breast neuroendocrine neoplasm 10.3 PGR ESR1
46 breast sarcoma 10.3 PGR CD34
47 gender identity disorder 10.3 PGR ESR1
48 intravascular fasciitis 10.3 ESR1 CD34
49 vagina sarcoma 10.3 PGR CD34
50 progesterone resistance 10.3 PGR ESR1

Comorbidity relations with Trigonitis via Phenotypic Disease Network (PDN):


Acute Cystitis Female Stress Incontinence
Hypertension, Essential Urethral Stricture
Urethritis

Graphical network of the top 20 diseases related to Trigonitis:



Diseases related to Trigonitis

Symptoms & Phenotypes for Trigonitis

MGI Mouse Phenotypes related to Trigonitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.4 ACLY CD34 CXCR2 DPP4 ESR1 LAMP1

Drugs & Therapeutics for Trigonitis

Drugs for Trigonitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
2 Hormones Phase 4
3 Immunosuppressive Agents Phase 4
4 Hormone Antagonists Phase 4
5 Immunologic Factors Phase 4
6 glucocorticoids Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Parasympatholytics Phase 3
9 Trospium chloride Phase 3 10405-02-4
10 Solifenacin succinate Phase 3 242478-38-2
11 Muscarinic Antagonists Phase 3
12
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
13
Manganese Approved, Nutraceutical Phase 2 7439-96-5 27854
14 incobotulinumtoxinA Phase 2
15 Trace Elements Phase 2
16 Nutrients Phase 2
17 Micronutrients Phase 2
18 Ether Phase 2
19
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
20
Acetylcholine Approved, Investigational 51-84-3 187
21
Triamcinolone Approved, Vet_approved 124-94-7 31307
22
Ropivacaine Approved 84057-95-4 71273 175805
23
Betamethasone Approved, Vet_approved 378-44-9 9782
24
tannic acid Approved 1401-55-4
25
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
26
Lidocaine Approved, Vet_approved 137-58-6 3676
27 Anesthetics, Local
28 abobotulinumtoxinA
29 Cholinergic Agents
30 Botulinum Toxins, Type A
31 Neurotransmitter Agents
32 Botulinum Toxins
33 Cholinergic Antagonists
34 Anesthetics
35 Triamcinolone diacetate
36 Triamcinolone hexacetonide
37 triamcinolone acetonide
38 Calamus

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Efficacy of Peri-trigonal Onabotulinumtoxin Injections in the Treatment of Refractory Idiopathic Detrusor Overactivity (IDO): A Single-blind, Randomised Controlled Trial Comparing Peri-trigonal Injections vs Injection of the Bladder Body. Unknown status NCT02009540 Phase 4 Botulinum toxin injected to bladder body;Botulinum toxin injected into trigone
2 Comparison Between Blind and Ultrasound Guided Injection in Morton Neuroma Unknown status NCT03046108 Phase 4 blind injection of Mepivacaine;blind injection of Triamcinolone;guided injection of mepivacaine;guided injection of Triamcinolone
3 The Impact of Injection Location on the Efficacy of Intravesicular Onabotulinumtoxin A in Interstitial Cystitis--Phase 4 Completed NCT02297100 Phase 4 Onabotulinumtoxin A
4 Effect of Botox Treatment for Neurogenic Detrusor Overactivity on the Prevention of Autonomic Dysreflexia Following Spinal Cord Injury Completed NCT02298660 Phase 4 BOTOX
5 Efficacy and Impact of Botulinum Toxin A Versus Anticholinergic Therapy for the Treatment of Bothersome Urge Urinary Incontinence Completed NCT01166438 Phase 3 Botulinum toxin A (Botox A®);Solifenacin 5mg;Solifenacin 10mg;Trospium chloride
6 Refractory Urge Incontinence and Botox Injections Terminated NCT00373789 Phase 3 Botulinum Toxin A, bladder detrusor muscle injection;Vehicle saline as placebo
7 Comparative Study of the Efficacy and Safety Between Suburothelial and Trigonal Intravesical Botulinum Toxin A Injection in Treatment of Interstitial Cystitis Refractory to Conventional Treatment - A Prospective, Randomized, Clinical Trial Unknown status NCT03076762 Phase 2 intravesical onabotulinumtoxinA injection
8 A Randomized, Blinded, Placebo Controlled Phase 2 Trial of Concurrent Radiation Therapy and Cisplatin With and Without BMX-001 in Patients With Locally Advanced Head and Neck Cancer Not yet recruiting NCT04607642 Phase 2 BMX-001;Cisplatin
9 Trigonal-sparing Versus Trigonal-involved Intravesical Botulinumtoxin A Injection in Refractory Idiopathic Detrusor Overactivity. Completed NCT03533062 botulinum toxin A
10 Inferior Alveolar Nerve Block for Intraoperative Analgesia for Maxillofacial Cancer Surgery Requiring Unilateral Mandibular Resection-A Randomized Controlled Study Completed NCT02745288
11 Prevention of Mandibular Third Molar Extraction- Associated Periodontal Defects Using Platelet-Rich Fibrin Completed NCT04033744
12 Observational Prospective Single Centre Study of the Response to Interventional Pain Management Techniques in Chronic Low Back Pain in Adults. 1 and 6 Months Follow-up. Multivariate Analysis of Predictors of Response. Predictive Model. Recruiting NCT04451252
13 Selective Bladder Denervation Using RF Energy for the Treatment of UUI Recruiting NCT04408352
14 Evaluation of Professional Practices in Botulinum Toxin Type A Intradetrusor Injection, at the Dose of 50 Units for the Treatment of Urinary Incontinence by Refractory Idiopathic Overactive Bladder Recruiting NCT04075578 OnabotulinumtoxinA / Botox®, Allergan Ltd, Irvine, CA, United-States

Search NIH Clinical Center for Trigonitis

Genetic Tests for Trigonitis

Anatomical Context for Trigonitis

MalaCards organs/tissues related to Trigonitis:

40
Breast, Cervix, Spinal Cord, Lung, Prostate, Smooth Muscle, Colon

Publications for Trigonitis

Articles related to Trigonitis:

(show all 41)
# Title Authors PMID Year
1
[Laser technology applications in functional urology and urogynecology.] 61
33025916 2020
2
Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection. 61
31002774 2019
3
Is trigonitis a neglected, imprecise, misunderstood, or forgotten diagnosis? 61
30989795 2019
4
Impact of Allergy and Resistance on Antibiotic Selection for Recurrent Urinary Tract Infections in Older Women. 61
29196069 2018
5
Recurrent Urinary Tract Infections Due to Bacterial Persistence or Reinfection in Women-Does This Factor Impact Upper Tract Imaging Findings? 61
26880409 2016
6
A prospective study to evaluate the efficacy of Cistiquer in improving lower urinary tract symptoms in females with urethral syndrome. 61
25034330 2014
7
Pseudomembranous trigonitis in a male with Klinefelter syndrome: a case report and evidence of a hormonal etiology. 61
25031763 2014
8
Is routine cystoscopy justified in female stress urinary incontinence? 61
22369022 2011
9
Treatment of urethral syndrome: a prospective randomized study with Nd:YAG laser. 61
16493214 2006
10
Transabdominal vesical sonography of urethral syndrome and stress incontinence. 61
12534925 2003
11
Chronic pelvic pain. Laparoscopic and cystoscopic findings. 61
11590449 2001
12
Outflow uropathy: occupational disorder? 61
10554477 1999
13
Effect of high-dose melphalan and peripheral blood stem cell transplantation on renal function in patients with multiple myeloma and renal insufficiency: a case report and review of the literature. 61
10348151 1999
14
[Several comments and various considerations on Von Brunn nests]. 61
8191950 1994
15
Immunohistochemical detection of estrogen and progesterone receptors in the normal urinary bladder and in pseudomembranous trigonitis. 61
1491120 1992
16
[Vesical ultrasonography and internal examination of female patients with urethral syndrome]. 61
1507726 1992
17
Sensory disorders of the lower urinary tract: urodynamic evaluation. 61
1414722 1992
18
The fine structure of human pseudomembranous trigonitis. 61
2611616 1989
19
Pseudomembranous trigonitis of the bladder: hormonal aetiology. 61
2794080 1989
20
[Whatever became of trigonitis]. 61
3177056 1988
21
Urethral syndrome (abacterial cystitis)--search for a pathogen. 61
2998533 1985
22
[Our experience in the medical therapy of chronic cervico-trigonitis]. 61
4053547 1985
23
[Value of cystoscopy in the study of the urogynecological patient]. 61
744491 1978
24
Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. 61
636125 1978
25
Urological problems in aged patients. 61
67838 1977
26
Urinary tract disorders. Clinical comparison of flavoxate and phenazopyridine. 61
1093308 1975
27
Histological findings in pseudomembranous trigonitis. 61
5118826 1971
28
Pseudomembranoous trigonitis. 61
5420763 1970
29
Trigonitis during pregnancy. A method of treatment. 61
13746217 1961
30
Frequency in the female due to urethro-trigonitis caused by intestinal infection. 61
13356048 1956
31
Topical use of cortisone in urology. 61
13150216 1954
32
[Trigonitis secondary to inflammatory processes of the uterine cervix]. 61
13142343 1953
33
Segmental nerve lesions as a cause of the trigonitis syndrome. 61
13056835 1953
34
[Chronic urethro-trigonitis in women]. 61
12995103 1952
35
Chronic urethro-trigonitis in the female. 61
15417310 1950
36
Acute urinary tract complications following general surgical procedures. 61
18146912 1949
37
The aetiology and treatment of trigonitis in the female. 61
18100624 1948
38
Epithelium of vaginal type in the female trigone; the clinical problem of trigonitis. 61
20243913 1947
39
Clinical report of the frequent association of trigonitis with chronic cervicitis and vaginitis; diagnosis and treatment. 61
20290774 1947
40
Urethro-trigonitis in relation to abacterial pyuria. 61
20284829 1946
41
OBSCURE PSEUDOMEMBRANOUS TRIGONITIS: TRIGONITIS AREATA ALBA. 61
17856488 1935

Variations for Trigonitis

Expression for Trigonitis

Search GEO for disease gene expression data for Trigonitis.

Pathways for Trigonitis

GO Terms for Trigonitis

Cellular components related to Trigonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.13 TNFSF10 TNFRSF10D TLR5 SLC5A4 SLC5A2 SLC5A1
2 extracellular exosome GO:0070062 9.97 TNFSF10 SLC5A2 SLC5A1 SI MGAM LAMP1
3 integral component of membrane GO:0016021 9.97 TNFSF10 TNFRSF10D TLR5 SLC5A4 SLC5A2 SLC5A1
4 cell surface GO:0009986 9.72 TNFRSF10D LAMP1 DPP4 CXCR2 CD34
5 plasma membrane GO:0005886 9.5 TNFSF10 TNFRSF10D TLR5 TAC1 SLC5A4 SLC5A2
6 apical plasma membrane GO:0016324 9.35 SLC5A1 SI MGAM DPP4 CD34

Biological processes related to Trigonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.97 TNFSF10 TNFRSF10D TLR5 PGR ESR1 CXCR2
2 sodium ion transport GO:0006814 9.63 SLC5A4 SLC5A2 SLC5A1
3 male gonad development GO:0008584 9.58 TNFSF10 TLR5 ESR1
4 sodium ion import across plasma membrane GO:0098719 9.43 SLC5A2 SLC5A1
5 intracellular steroid hormone receptor signaling pathway GO:0030518 9.32 PGR ESR1
6 paracrine signaling GO:0038001 9.26 PGR CD34
7 polysaccharide digestion GO:0044245 9.16 SI MGAM
8 glucose import across plasma membrane GO:0098708 8.96 SLC5A2 SLC5A1
9 alpha-glucoside transport GO:0000017 8.62 SLC5A2 SLC5A1

Molecular functions related to Trigonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 D-glucose transmembrane transporter activity GO:0055056 9.32 SLC5A2 SLC5A1
2 alpha-1,4-glucosidase activity GO:0004558 9.26 SI MGAM
3 TRAIL binding GO:0045569 9.16 TNFSF10 TNFRSF10D
4 alpha-glucoside transmembrane transporter activity GO:0015151 8.96 SLC5A2 SLC5A1
5 glucose:sodium symporter activity GO:0005412 8.8 SLC5A4 SLC5A2 SLC5A1

Sources for Trigonitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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