MCID: TRG001
MIFTS: 29

Trigonitis

Categories: Nephrological diseases

Aliases & Classifications for Trigonitis

MalaCards integrated aliases for Trigonitis:

Name: Trigonitis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13507
ICD9CM 36 595.3
NCIt 51 C123175
SNOMED-CT 69 74445007
ICD10 34 N30.3
UMLS 74 C1261278

Summaries for Trigonitis

MalaCards based summary : Trigonitis is related to meningioma, familial and leiomyoma. An important gene associated with Trigonitis is PGR (Progesterone Receptor), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Signaling by ERBB4. Affiliated tissues include ovary, cervix and bone marrow, and related phenotypes are hematopoietic system and integument

Wikipedia : 77 Trigonitis is a condition of inflammation of the trigone region of the bladder. It is more common in... more...

Related Diseases for Trigonitis

Diseases related to Trigonitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 meningioma, familial 30.2 CD34 ESR1 PGR
2 leiomyoma 29.8 CD34 ESR1 PGR
3 bladder trigone cancer 12.4
4 interstitial cystitis 11.6
5 glandular cystitis 11.2
6 spinal meningioma 10.3
7 secretory meningioma 10.3
8 cystitis 10.2
9 leiomyomatosis 10.2 ESR1 PGR
10 myoma 10.2 ESR1 PGR
11 vestibular gland benign neoplasm 10.2 ESR1 PGR
12 prostate stromal sarcoma 10.2 CD34 PGR
13 bartholin's gland adenoma 10.2 ESR1 PGR
14 vulvar syringoma 10.2 ESR1 PGR
15 lung leiomyoma 10.2 ESR1 PGR
16 glassy cell carcinoma of the cervix 10.2 ESR1 PGR
17 vulvar benign neoplasm 10.2 ESR1 PGR
18 vulvar leiomyoma 10.2 ESR1 PGR
19 lung meningioma 10.2 CD34 PGR
20 predominantly cortical thymoma 10.2 ESR1 PGR
21 vulvar dystrophy 10.2 CD34 PGR
22 breast medullary carcinoma 10.2 ESR1 PGR
23 breast scirrhous carcinoma 10.2 ESR1 PGR
24 bartholin's gland benign neoplasm 10.2 ESR1 PGR
25 oncocytic breast carcinoma 10.2 ESR1 PGR
26 progesterone-receptor positive breast cancer 10.2 ESR1 PGR
27 progesterone resistance 10.2 ESR1 PGR
28 endometrial squamous cell carcinoma 10.2 ESR1 PGR
29 cribriform carcinoma 10.2 ESR1 PGR
30 endometrial mucinous adenocarcinoma 10.2 ESR1 PGR
31 adenoid basal cell carcinoma 10.2 ESR1 PGR
32 apocrine adenocarcinoma 10.2 ESR1 PGR
33 gender identity disorder 10.2 ESR1 PGR
34 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
35 breast adenoid cystic carcinoma 10.2 ESR1 PGR
36 female reproductive endometrioid cancer 10.2 ESR1 PGR
37 cervical carcinosarcoma 10.2 ESR1 PGR
38 estrogen excess 10.2 ESR1 PGR
39 glycogen-rich clear cell breast carcinoma 10.2 ESR1 PGR
40 mammographic density 10.1 ESR1 PGR
41 cervical clear cell adenocarcinoma 10.1 ESR1 PGR
42 retinitis pigmentosa 47 10.1 ESR1 PGR
43 inflammatory breast carcinoma 10.1 ESR1 PGR
44 retinitis pigmentosa 20 10.1 ESR1 PGR
45 adenosarcoma 10.1 ESR1 PGR
46 luminal breast carcinoma 10.1 ESR1 PGR
47 endometriosis of ovary 10.1 ESR1 PGR
48 endometriosis 10.1 ESR1 PGR
49 vesicoureteral reflux 1 10.1
50 blood group, gerbich system 10.1

Comorbidity relations with Trigonitis via Phenotypic Disease Network (PDN):


Acute Cystitis Female Stress Incontinence
Hypertension, Essential Urethral Stricture
Urethritis

Graphical network of the top 20 diseases related to Trigonitis:



Diseases related to Trigonitis

Symptoms & Phenotypes for Trigonitis

MGI Mouse Phenotypes related to Trigonitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 AFM CD34 CSF3 ESR1 PGR
2 integument MP:0010771 8.92 CD34 CSF3 ESR1 PGR

Drugs & Therapeutics for Trigonitis

Search Clinical Trials , NIH Clinical Center for Trigonitis

Genetic Tests for Trigonitis

Anatomical Context for Trigonitis

MalaCards organs/tissues related to Trigonitis:

42
Ovary, Cervix, Bone Marrow, Smooth Muscle

Publications for Trigonitis

Articles related to Trigonitis:

(show all 16)
# Title Authors Year
1
Is trigonitis a neglected, imprecise, misunderstood, or forgotten diagnosis? ( 30989795 )
2019
2
Pseudomembranous trigonitis in a male with Klinefelter syndrome: a case report and evidence of a hormonal etiology. ( 25031763 )
2014
3
Immunohistochemical detection of estrogen and progesterone receptors in the normal urinary bladder and in pseudomembranous trigonitis. ( 1491120 )
1992
4
The fine structure of human pseudomembranous trigonitis. ( 2611616 )
1989
5
Pseudomembranous trigonitis of the bladder: hormonal aetiology. ( 2794080 )
1989
6
Histological findings in pseudomembranous trigonitis. ( 5118826 )
1971
7
Pseudomembranoous trigonitis. ( 5420763 )
1970
8
Trigonitis during pregnancy. A method of treatment. ( 13746217 )
1961
9
Frequency in the female due to urethro-trigonitis caused by intestinal infection. ( 13356048 )
1956
10
Segmental nerve lesions as a cause of the trigonitis syndrome. ( 13056835 )
1953
11
Chronic urethro-trigonitis in the female. ( 15417310 )
1950
12
The aetiology and treatment of trigonitis in the female. ( 18100624 )
1948
13
Clinical report of the frequent association of trigonitis with chronic cervicitis and vaginitis; diagnosis and treatment. ( 20290774 )
1947
14
Epithelium of vaginal type in the female trigone; the clinical problem of trigonitis. ( 20243913 )
1947
15
Urethro-trigonitis in relation to abacterial pyuria. ( 20284829 )
1946
16
OBSCURE PSEUDOMEMBRANOUS TRIGONITIS: TRIGONITIS AREATA ALBA. ( 17856488 )
1935

Variations for Trigonitis

Expression for Trigonitis

Search GEO for disease gene expression data for Trigonitis.

Pathways for Trigonitis

Pathways related to Trigonitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 CD34 CSF3
2
Show member pathways
11.19 ESR1 PGR
3 10.94 CD34 CSF3
4
Show member pathways
10.58 ESR1 PGR

GO Terms for Trigonitis

Biological processes related to Trigonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.32 CSF3 ESR1
2 negative regulation of neuron death GO:1901215 9.26 CD34 CSF3
3 steroid hormone mediated signaling pathway GO:0043401 9.16 ESR1 PGR
4 negative regulation of gene expression GO:0010629 9.13 CD34 ESR1 PGR
5 paracrine signaling GO:0038001 8.62 CD34 PGR

Molecular functions related to Trigonitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.32 ESR1 PGR
2 steroid hormone receptor activity GO:0003707 9.26 ESR1 PGR
3 nuclear receptor activity GO:0004879 9.16 ESR1 PGR
4 enzyme binding GO:0019899 9.13 CSF3 ESR1 PGR
5 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Trigonitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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