MCID: TRM026
MIFTS: 23

Trimethoprim Allergy

Categories: Immune diseases

Aliases & Classifications for Trimethoprim Allergy

MalaCards integrated aliases for Trimethoprim Allergy:

Name: Trimethoprim Allergy 12 15
Proloprim Allergy 12
Primsol Allergy 12
Tmp Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040029
UMLS 71 C0571390

Summaries for Trimethoprim Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger trimethoprim.

MalaCards based summary : Trimethoprim Allergy, also known as proloprim allergy, is related to phenytoin toxicity and meningococcal infection. An important gene associated with Trimethoprim Allergy is AOC1 (Amine Oxidase Copper Containing 1), and among its related pathways/superpathways are Metabolism and Drug metabolism - cytochrome P450. Affiliated tissues include liver and kidney.

Related Diseases for Trimethoprim Allergy

Diseases related to Trimethoprim Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 phenytoin toxicity 10.2 NAT2 CYP2C9
2 meningococcal infection 10.2 GSR G6PD
3 isoniazid toxicity 10.2 NAT2 CYP2E1
4 lymphosarcoma 10.2 GSR G6PD
5 sulfonamide allergy 10.2 G6PD CYP2C9
6 diabetic cataract 10.1 GSR G6PD
7 hydrops of gallbladder 10.1 GPT G6PD
8 toxic oil syndrome 10.1 NAT2 GSTM1
9 mutagen sensitivity 10.1 NAT2 GSTM1
10 halothane hepatitis 10.0 CYP2E1 CYP2C9
11 reye syndrome 10.0 GSR GPT
12 choline deficiency disease 10.0 GPT CYP2E1
13 hepatitis d 10.0 GPT CYP2C9
14 sister chromatid exchange, frequency of 10.0 GSTM1 CYP2E1
15 pulmonary artery disease 9.9 GPT CYP2C9
16 blackwater fever 9.9 HP G6PD
17 asbestosis 9.9 GSTM1 G6PD
18 primary thrombocytopenia 9.9 HP GP1BA
19 glucosephosphate dehydrogenase deficiency 9.8 HP G6PD
20 neonatal jaundice 9.8 GSTM1 G6PD
21 cardia cancer 9.8 GSTM1 CYP2E1
22 anemia, nonspherocytic hemolytic, due to g6pd deficiency 9.8 HP G6PD
23 anemia, autoimmune hemolytic 9.8 HP G6PD
24 nutmeg liver 9.8 HP GPT
25 alcoholic pancreatitis 9.8 GSTM1 CYP2E1
26 multiple chemical sensitivity 9.8 NAT2 GSTM1 CYP2C9
27 senile cataract 9.8 GSTM1 GSR G6PD
28 splenic infarction 9.8 HP GPT
29 babesiosis 9.7 HP GPT
30 bronchopneumonia 9.7 HP GPT
31 tobacco addiction 9.7 NAT2 GSTM1 CYP2E1
32 multinodular goiter 9.7 GSR G6PD
33 plasmodium falciparum malaria 9.6 HP GSR G6PD
34 protein-energy malnutrition 9.6 HP GPT
35 blood coagulation disease 9.5 HP GPT GP1BA
36 blood platelet disease 9.5 HP GPT GP1BA
37 gilbert syndrome 9.5 HP GPT G6PD
38 autoimmune disease of gastrointestinal tract 9.5 HP GPT
39 bilirubin metabolic disorder 9.5 HP GPT G6PD
40 pulmonary disease, chronic obstructive 9.5 GSTM1 GSR CYP2E1
41 parasitic protozoa infectious disease 9.5 HP GPT G6PD
42 viral hepatitis 9.5 HP GPT G6PD
43 thalassemia 9.5 HP GPT G6PD
44 cholecystitis 9.5 HP GPT
45 hemolytic anemia 9.4 HP GSR G6PD
46 liver cirrhosis 9.4 HP GPT CYP2E1
47 acute kidney failure 9.4 HP GPT
48 cataract 9.4 GSTM1 GSR GPT G6PD
49 alcoholic liver cirrhosis 9.3 NAT2 GSTM1 GPT CYP2E1
50 drug-induced hepatitis 9.0 NAT2 GSTM1 GPT CYP2E1 CYP2C9

Graphical network of the top 20 diseases related to Trimethoprim Allergy:



Diseases related to Trimethoprim Allergy

Symptoms & Phenotypes for Trimethoprim Allergy

Drugs & Therapeutics for Trimethoprim Allergy

Search Clinical Trials , NIH Clinical Center for Trimethoprim Allergy

Genetic Tests for Trimethoprim Allergy

Anatomical Context for Trimethoprim Allergy

MalaCards organs/tissues related to Trimethoprim Allergy:

40
Liver, Kidney

Publications for Trimethoprim Allergy

Articles related to Trimethoprim Allergy:

# Title Authors PMID Year
1
Desensitization to co-trimoxazole in a patient with fixed drug eruption. 61
18714541 2008

Variations for Trimethoprim Allergy

Expression for Trimethoprim Allergy

Search GEO for disease gene expression data for Trimethoprim Allergy.

Pathways for Trimethoprim Allergy

Pathways related to Trimethoprim Allergy according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 NAT2 GSTM1 GSR GPT G6PD CYP2E1
2
Show member pathways
12.49 NAT2 GSTM1 CYP2E1 CYP2C9
3
Show member pathways
12.43 NAT2 GSTM1 GSR CYP2E1 CYP2C9 AOC1
4
Show member pathways
11.99 GSTM1 GSR G6PD
5 11.66 GSTM1 GSR G6PD
6 11.24 HP GP1BA
7
Show member pathways
11.19 NAT2 GSTM1
8
Show member pathways
11.13 CYP2E1 CYP2C9
9 11.07 CYP2E1 CYP2C9
10
Show member pathways
10.93 CYP2E1 CYP2C9
11
Show member pathways
10.88 NAT2 CYP2E1
12 10.71 CYP2E1 CYP2C9
13 10.62 GSR G6PD
14 10.46 GPT G6PD
15 10.18 GSTM1 CYP2E1 CYP2C9
16 9.93 GSTM1 CYP2E1

GO Terms for Trimethoprim Allergy

Cellular components related to Trimethoprim Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.1 HP GSR GPT GP1BA G6PD AOC1

Biological processes related to Trimethoprim Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.65 GSR G6PD CYP2E1 CYP2C9 AOC1
2 exogenous drug catabolic process GO:0042738 9.46 CYP2E1 CYP2C9
3 drug metabolic process GO:0017144 9.43 CYP2E1 CYP2C9
4 long-chain fatty acid biosynthetic process GO:0042759 9.4 CYP2E1 CYP2C9
5 organic acid metabolic process GO:0006082 9.37 CYP2E1 CYP2C9
6 epoxygenase P450 pathway GO:0019373 9.32 CYP2E1 CYP2C9
7 monoterpenoid metabolic process GO:0016098 9.16 CYP2E1 CYP2C9
8 glutathione metabolic process GO:0006749 9.13 GSTM1 GSR G6PD
9 xenobiotic metabolic process GO:0006805 8.92 NAT2 CYP2E1 CYP2C9 AOC1

Molecular functions related to Trimethoprim Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monooxygenase activity GO:0004497 9.4 CYP2E1 CYP2C9
2 NADP binding GO:0050661 9.37 GSR G6PD
3 steroid hydroxylase activity GO:0008395 9.32 CYP2E1 CYP2C9
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.26 CYP2E1 CYP2C9
5 aromatase activity GO:0070330 9.16 CYP2E1 CYP2C9
6 oxidoreductase activity GO:0016491 9.02 GSR G6PD CYP2E1 CYP2C9 AOC1
7 arachidonic acid epoxygenase activity GO:0008392 8.96 CYP2E1 CYP2C9

Sources for Trimethoprim Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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