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MCID: TRP009
MIFTS: 42

Triple X Syndrome

Categories: Endocrine diseases, Fetal diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Triple X Syndrome

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MalaCards integrated aliases for Triple X Syndrome:

Name: Triple X Syndrome 74 52 25 58
Xxx Syndrome 52 25 58
Trisomy X 52 25 58
Trisomy X Syndrome 29 71
Triplo X Syndrome 52 25
47,xxx Syndrome 25 58
47,xxx 74 25
Triple-X Chromosome Syndrome 52
Triplo-X Syndrome 58
47 Xxx Syndrome 52
Triple-X Female 52

Characteristics:

Orphanet epidemiological data:

58
trisomy x
Inheritance: Not applicable; Age of onset: Childhood,Infancy; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare infertility disorders
Rare gynaecological and obstetric diseases
Rare endocrine diseases
Developmental anomalies during embryogenesis


External Ids:

MESH via Orphanet 44 D014314
ICD10 via Orphanet 33 Q97.0
UMLS via Orphanet 72 C0221033
Orphanet 58 ORPHA3375
UMLS 71 C0221033
Sources

Summaries for Triple X Syndrome

About this section
NIH Rare Diseases : 52 47 XXX syndrome , also called trisomy X or triple X syndrome, is characterized by the presence of an additional (third) X chromosome in each of a female's cells (which normally have two X chromosomes ). An extra copy of the X chromosome is associated with tall stature, learning problems, and other features in some girls and women. Seizures or kidney abnormalities occur in about 10 percent of affected females. 47 XXX syndrome is usually caused by a random event during the formation of reproductive cells (eggs and sperm). An error in cell division called nondisjunction can result in reproductive cells with an abnormal number of chromosomes. Treatment typically focuses on specific symptoms, if present. Some females with 47 XXX syndrome have an extra X chromosome in only some of their cells; this is called 46,XX/47,XXX mosaicism .

MalaCards based summary : Triple X Syndrome, also known as xxx syndrome, is related to premature ovarian failure 1 and numeric sex chromosome variations. An important gene associated with Triple X Syndrome is SHOX (Short Stature Homeobox). The drugs Metformin and Entecavir have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and kidney, and related phenotypes are abnormality of chromosome segregation and global developmental delay

Genetics Home Reference : 25 Triple X syndrome, also called trisomy X or 47,XXX, is characterized by the presence of an additional X chromosome in each of a female's cells. Although females with this condition may be taller than average, this chromosomal change typically causes no unusual physical features. Most females with triple X syndrome have normal sexual development and are able to conceive children. Triple X syndrome is associated with an increased risk of learning disabilities and delayed development of speech and language skills. Delayed development of motor skills (such as sitting and walking), weak muscle tone (hypotonia), and behavioral and emotional difficulties are also possible, but these characteristics vary widely among affected girls and women. Seizures or kidney abnormalities occur in about 10 percent of affected females.

Wikipedia : 74 Triple X syndrome, also known as trisomy X and 47,XXX, is characterized by the presence of an extra X... more...

Sources

Related Diseases for Triple X Syndrome

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Diseases related to Triple X Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 premature ovarian failure 1 11.5
2 numeric sex chromosome variations 11.2
3 chromosome xq duplication 11.1
4 turner syndrome 10.4
5 47,xyy 10.3
6 nondisjunction 10.3
7 48, xxxx 10.3
8 48,xyyy 10.2
9 autoimmune disease 10.2
10 renal hypodysplasia/aplasia 1 10.2
11 chromosomal triplication 10.1
12 systemic lupus erythematosus 10.1
13 rett syndrome 10.1
14 46 xx gonadal dysgenesis 10.1
15 tic disorder 10.1
16 amenorrhea 10.0
17 cat eye syndrome 9.9
18 attention deficit-hyperactivity disorder 9.9
19 otitis media 9.9
20 prader-willi syndrome 9.9
21 sarcoidosis 1 9.9
22 scott syndrome 9.9
23 taurodontism 9.9
24 tooth size 9.9
25 anxiety 9.9
26 ring chromosome 14 syndrome 9.9
27 autism spectrum disorder 9.9
28 cloacal exstrophy 9.9
29 tonsillitis 9.9
30 intestinal atresia 9.9
31 premature menopause 9.9
32 transsexualism 9.9
33 infant gynecomastia 9.9
34 allergic hypersensitivity disease 9.9
35 primary biliary cirrhosis 9.9
36 gender identity disorder 9.9
37 gynecomastia 9.9
38 epilepsy 9.9
39 hypogonadism 9.9
40 focal epilepsy 9.9
41 mood disorder 9.9
42 kallmann syndrome 9.9
43 peritonitis 9.9
44 lupus erythematosus 9.9
45 encephalocele 9.9
46 horseshoe kidney 9.9
47 lower mesodermal defects sequence 9.9
48 mosaic trisomy 8 9.9
49 sternal cleft 9.9
50 urogenital adysplasia 9.9

Graphical network of the top 20 diseases related to Triple X Syndrome:



Diseases related to Triple X Syndrome
Sources

Symptoms & Phenotypes for Triple X Syndrome

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Human phenotypes related to Triple X Syndrome:

58 31 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of chromosome segregation 58 31 hallmark (90%) Very frequent (99-80%) HP:0002916
2 global developmental delay 58 31 frequent (33%) Frequent (79-30%) HP:0001263
3 muscular hypotonia 58 31 frequent (33%) Frequent (79-30%) HP:0001252
4 cognitive impairment 58 31 frequent (33%) Frequent (79-30%) HP:0100543
5 specific learning disability 58 31 frequent (33%) Frequent (79-30%) HP:0001328
6 epicanthus 58 31 frequent (33%) Frequent (79-30%) HP:0000286
7 clinodactyly of the 5th finger 58 31 frequent (33%) Frequent (79-30%) HP:0004209
8 tall stature 58 31 frequent (33%) Frequent (79-30%) HP:0000098
9 hypertelorism 58 31 occasional (7.5%) Occasional (29-5%) HP:0000316
10 hip dysplasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001385
11 tremor 58 31 occasional (7.5%) Occasional (29-5%) HP:0001337
12 attention deficit hyperactivity disorder 58 31 occasional (7.5%) Occasional (29-5%) HP:0007018
13 anxiety 58 31 occasional (7.5%) Occasional (29-5%) HP:0000739
14 secondary amenorrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0000869
15 depressivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0000716
16 pectus excavatum 58 31 occasional (7.5%) Occasional (29-5%) HP:0000767
17 renal hypoplasia/aplasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0008678
18 upslanted palpebral fissure 58 31 occasional (7.5%) Occasional (29-5%) HP:0000582
19 joint hyperflexibility 58 31 occasional (7.5%) Occasional (29-5%) HP:0005692
20 multicystic kidney dysplasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000003
21 seizure 31 occasional (7.5%) HP:0001250
22 seizures 58 Occasional (29-5%)
Sources

Drugs & Therapeutics for Triple X Syndrome

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Drugs for Triple X Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 789)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
3
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
4
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
5
Tranexamic Acid Approved Phase 4 1197-18-8 5526
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
8
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
9
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
10
Glimepiride Approved Phase 4 93479-97-1 3476
11
Glyburide Approved Phase 4 10238-21-8 3488
12
Ciclesonide Approved, Investigational Phase 4 141845-82-1, 126544-47-6 444033
13
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
14
Insulin glargine Approved Phase 4 160337-95-1
15
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
16
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
17
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
18
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
19
Lixisenatide Approved Phase 4 320367-13-3
20
Abciximab Approved Phase 4 143653-53-6
21
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
22
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
23
Haloperidol Approved Phase 4 52-86-8 3559
24
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
25
Morphine Approved, Investigational Phase 4 57-27-2 5288826
26
Ribavirin Approved Phase 4 36791-04-5 37542
27
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
28
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
29
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
30
Remifentanil Approved Phase 4 132875-61-7 60815
31
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
32
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
33
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
34
Phenylephrine Approved Phase 4 59-42-7 6041
35
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
36
Adenosine Approved, Investigational Phase 4 58-61-7 60961
37
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
38
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
39
Racepinephrine Approved Phase 4 329-65-7 838
40
Travoprost Approved Phase 4 157283-68-6 5282226
41
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
42
Dorzolamide Approved Phase 4 120279-96-1 5284549 3154
43
Brinzolamide Approved Phase 4 138890-62-7 68844
44
Timolol Approved Phase 4 26839-75-8 5478 33624
45
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
46
Norepinephrine Approved Phase 4 51-41-2 439260
47
Pseudoephedrine Approved Phase 4 90-82-4 7028
48
Ephedrine Approved Phase 4 299-42-3 9294
49
Histamine Approved, Investigational Phase 4 51-45-6 774
50
Loratadine Approved, Investigational Phase 4 79794-75-5 3957

Interventional clinical trials:

(show top 50) (show all 1135)
# Name Status NCT ID Phase Drugs
1 Clinical Trial Program of a Medical Instrument Product Unknown status NCT01157455 Phase 4 Aspirin;Clopidogrel;Heparin or Bivalirudin
2 Phase IV Study of the Efficacy of Entecavir in Patients With Chronic Hepatitis B Virus Infection and Persistently Normal Alanine Aminotransferase Unknown status NCT01833611 Phase 4 Entecavir;placebo
3 Cross-reactivity and Tolerability of Ertapenem in Patients With IgE-mediated Allergy to Beta-lactams Unknown status NCT01159379 Phase 4 ertapenem
4 Minimization of Bleeding Complications Through Utilization of Perioperative Tranexamic Acid in Breast Surgery: A Randomized Double-blinded Placebo-controlled Trial Unknown status NCT02615366 Phase 4 Tranexamic Acid;Placebo
5 A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. "KYMES" Unknown status NCT01168700 Phase 4 aged garlic extract;Placebo
6 Pulpal Blood Flow With the Use of Intra-nasal Anesthetic: a Randomized Double-blind Crossover Study Unknown status NCT03368391 Phase 4 tetracaine HCl and oxymetazoline HCL;2% Lidocaine with 1:100,000 epinephrine;3% Mepivacaine with 1:100,000 epinephrine;saline intranasal;saline infiltration
7 Effects on Incidence of Cardiovascular Events of the Addition of Pioglitazone as Compared With a Sulphonylurea in Type 2 Diabetic Patients Inadequately Controlled With Metformin. Unknown status NCT00700856 Phase 4 add-on pioglitazone;add-on sulphonylurea
8 Phase 4 Cost-effectiveness Study of Beclomethasone Versus Ciclesonide as Controller Medications in Pediatric Asthma in a Hospital in Bogotá Completed NCT01333800 Phase 4 Beclomethasone;Ciclesonide
9 Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS Completed NCT03644212 Phase 4 Vitamin D3
10 A Phase IV Open, Randomized, Controlled Study to Evaluate the Safety and Immunogenicity of a Pediatric Presentation (0.25 ml) of the Virosomal Hepatitis A Virus (HAV) Vaccine HAVpur in Healthy Young Children Aged Between and Including 18 Months to 47 Months, Using a 0/6 Month Immunization Schedule Completed NCT01349829 Phase 4
11 Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment Completed NCT02408445 Phase 4 testosterone cypionate 200mg/ml
12 Modified Non-clarithromycin Triple Therapy in Eradicating Helicobacter Pylori Completed NCT02776371 Phase 4 Modified non-clarithromycin triple therapy;Sequential therapy
13 Study of the Effect of Calcifediol Supplementation on Left Ventricular Function in Cardiopathic Patients Undergoing Major Orthopedic Surgery. Completed NCT03403933 Phase 4 Didrogyl
14 A Randomized, Multicenter, Open-Label, Parallel-Group, 28 Days Phase IV Study Comparing The Postprandial Plasma Glucose Profile of Lixisenatide With That of Sitagliptin Add-On to Insulin Glargine in Type 2 Diabetes Mellitus Completed NCT02200991 Phase 4 LIXISENATIDE AVE0010;Sitagliptin;Insulin glargine HOE901
15 Anti-inflammatory Effects of Intracoronary and Intravenous Abciximab Administration During Primary Percutaneous Coronary Intervention.(Molecole di Adesione Nella Sindrome Coronarica Acuta Completed NCT01757457 Phase 4 Intracoronary administration of an abciximab bolus during primary PCI;Intravenous administration of an abciximab bolus during primary PCI
16 Efficacy and Safety of Risperidone Oral Solution Combination Clonazepam Versus Haloperidol IM Injection for Treatment of Acute Psychotic Agitation in Schizophrenia Completed NCT00859872 Phase 4 risperidone oral solution;haloperidol
17 Reveal® XT Performance Trial Completed NCT00680927 Phase 4
18 Respiratory Muscle Stretching in Patients With Chronic Obstructive Pulmonary Disease Submitted a Pulmonary Rehabilitation Program Completed NCT00935181 Phase 4
19 A Feasibility Study: Understanding and Altering Pain Expectations in Subjects With Osteoarthritis of the Knee or Hip Completed NCT02155257 Phase 4 Modafinil;Gabapentin;Placebo
20 Oral Nystatin Prophylaxis to Prevent Systemic Fungal Infection in Very Low Birth Weight Preterm Infants: a Randomized Controlled Trial Completed NCT03390374 Phase 4 Nystatin Oral
21 The Effect of Prior Short Course Combination Antiretroviral Therapy Administered for the Prevention of Mother-to-Child Transmission (pMTCT) of HIV-1 on Subsequent Treatment Efficacy in Treatment-"Nearly Naive" Participants Completed NCT00442962 Phase 4 Efavirenz;Emtricitabine/Tenofovir disoproxil fumarate
22 Target-controlled Infusion of Propofol and Remifentanil During General Anaesthesia Guided by Entropy of the Electroencephalogram: Comparison Between Manual Perfusion and Automated Perfusion Completed NCT00391885 Phase 4
23 Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients; Randomized Prospective Study Completed NCT00355732 Phase 4
24 A New Strategy Regarding Discontinuation of Dual Antiplatelet; Real Safety and Efficacy of a 3-month Dual Antiplatelet Therapy Following Zotarolimus-eluting Stents Implantation (RESET Trial) Completed NCT01145079 Phase 4
25 Prospective Randomized Trial to Evaluate the Efficacy of Donor Preconditioning With Dopamine on Initial Graft Function After Kidney Transplantation Completed NCT00115115 Phase 4 Dopamine infusion to brain dead organ donors
26 Prospective, Randomized Clinical Trial,to Compare Standard Trabeculectomy to the Ex-PRESS Mini Glaucoma Shunt Implantation Under a Scleral Flap in Eyes With Open-Angle Glaucoma Completed NCT00698438 Phase 4
27 The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment Completed NCT03121521 Phase 4 Melatonin 10 mg;Placebo
28 ADenosine Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination: the ADVICE Trial Completed NCT01058980 Phase 4
29 A Randomized Trial Comparing Daily Atropine Versus Weekend Atropine Completed NCT00094614 Phase 4 Atropine
30 Choroidal Thickness and Its Correlations With Ocular Parameters in Cases With Primary Open-angle Glaucoma Completed NCT03966560 Phase 4 Brimonidine Tartrate;Dorzolamide (as Dorzolamide Hydrochloride) 20 Mg/mL and Timolol (as Timolol Maleate) 5 Mg/mL Eye Drops;Brinzolamide/Timolol 10 MG/1 ML-5 MG/1 ML Ophthalmic Suspension;Travoprost and Timolol;Bimatoprost and Timolol;Latanoprost
31 Comparison of the Effect of Fluoride Remineralizer Gel and Foam: a Randomized Clinical Trial Completed NCT02490592 Phase 4
32 Effect of Aspirin Intake on Awakening Versus at Bedtime on Circadian Rhythm of Platelet Reactivity in Healthy Subjects Completed NCT01900639 Phase 4
33 Crystalloid Coload Combined With Variable Rate Phenylephrine Infusion for Prevention of Hypotension During Spinal Anesthesia for Elective Cesarean Delivery vs Crystalloid Coload Alone Completed NCT01378325 Phase 4 Phenylephrine;saline
34 A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Evaluating the Pharmacodynamic Effect of a 6-week Treatment With Triamcinolone Acetonide Aqueous Nasal Spray 110 μg and 220 μg Once Daily on Basal Hypothalamic-Pituitary-Adrenal (HPA) Axis Function in Children [>=2 to < 12 Years of Age] With Allergic Rhinitis (AR). Completed NCT01154153 Phase 4 Placebo nasal spray;Triamcinolone acetonide aqueous (TAA-AQ) nasal spray (NASACORT AQ);Placebo nasal spray;Claritin® Syrup
35 Clinical Evaluation of Day and Night Skin Care Creams Supplemented With MediCell Technology (MCT)'s Composition of Defensins and Supportive Molecules Completed NCT02765763 Phase 4 2-Minute Reveal Masque;24/7 Barrier Repair Cream;8-in-1 BioSerum;Null Formula 2-Minute Reveal Masque;Null Formula 24/7 Barrier Repair Cream;Null Formula 8-in-1 BioSerum
36 Effects of Nitroglycerin Versus Labetalol on Tissue Perfusion During Deliberate Hypotension for Sinus Endoscopic Surgery. Completed NCT03809065 Phase 4 Nitroglycerin;Labetalol
37 Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
38 A Randomized, Double-blind, Comparator-controlled Trial to Assess the Effect of 12-week Treatment With Dapagliflozin Versus Gliclazide on Renal Physiology and Biomarkers in Metformin-treated Patients With Type 2 Diabetes Mellitus Completed NCT02682563 Phase 4 Dapagliflozin 10mg QD;Gliclazide 30mg QD
39 Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial Completed NCT02267538 Phase 4 dexmedetomidine hydrochloride for injection;0.9% sodium chloride for injection
40 Nasally Inhaled Isopropyl Alcohol Versus Oral Ondansetron for the Treatment of Nausea in the Emergency Department: A Double-Blind Randomized Controlled Trial Completed NCT02760069 Phase 4 Inhaled isopropyl alcohol;Oral ondansetron;Inhaled normal saline;Oral placebo
41 Prospective, Randomized Clinical Trial of a Silver Eluting Dressing System for Prevention of Lower Extremity Revascularization Wound Complications Completed NCT01229358 Phase 4
42 Effects of Anemia Correction on Vascular Function, Endothelial Cell Markers and Monocyte Apoptosis in Renal Transplant Recipients Completed NCT00204334 Phase 4 darbopoeitin
43 Incontinence & Intimate Partners: Assessing the Contribution of Treatment Completed NCT01559389 Phase 4 Solifenacin
44 Effectiveness and Safety of Inactivated EV71 Vaccine (Human Diploid Cell) in 6-71 Months Children: an Open-label Controlled Phase â…£ Clinical Study Completed NCT03001986 Phase 4
45 Randomized Trial of 24 or 48 Weeks of Peginterferon Alfa-2a Plus Ribavirin for Chronic Hepatitis C Virus Genotype 1-infected Patients in Taiwan Completed NCT00495131 Phase 4 Pegylated interferon alfa-2a plus ribavirin;Pegylated interferon alfa-2a plus ribavirin
46 Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentric Trial Completed NCT00914095 Phase 4 methylphenidate;placebo
47 Effects of Eplerenone on Left Ventricular Hypertrophy in Patients With Resistant Hypertension and Obstructive Sleep Apnoea Completed NCT03186742 Phase 4 Eplerenone 50 mg Tab
48 Nicotine Replacement Therapy Added to Cognitive Behavioral Therapy for Smoking Cessation in Patients With Major Mental Illness Completed NCT00320723 Phase 4 bupropion, transdermal nicotine patch
49 Midazolam With Meperidine and Dexmedetomidine vs Midazolam With Meperidine for Sedation During ERCP Completed NCT01404689 Phase 4 Dexmedetomidine
50 Pneumococcal Conjugate Vaccine (PCV) Schedules for the Northern Territory (NT): Randomised Controlled Trial of Booster Vaccines to Broaden and Strengthen Protection From Invasive and Mucosal Infections. Completed NCT01735084 Phase 4

Search NIH Clinical Center for Triple X Syndrome

Sources

Genetic Tests for Triple X Syndrome

About this section

Genetic tests related to Triple X Syndrome:

# Genetic test Affiliating Genes
1 Trisomy X Syndrome 29
Sources

Anatomical Context for Triple X Syndrome

About this section

MalaCards organs/tissues related to Triple X Syndrome:

40
Breast, Lung, Kidney, Testes, Prostate, Heart, Bone
Sources

Publications for Triple X Syndrome

About this section

Articles related to Triple X Syndrome:

(show top 50) (show all 108)
# Title Authors PMID Year
1
The epidemiology of sex chromosome abnormalities. 61
32506765 2020
2
Epigenetic and transcriptomic consequences of excess X-chromosome material in 47,XXX syndrome-A comparison with Turner syndrome and 46,XX females. 61
32489015 2020
3
Evaluating the Scope of Language Impairments in a Patient with Triple X Syndrome: A Brief Report. 61
32419557 2020
4
Cell-free DNA screening for sex chromosome aneuploidies by non-invasive prenatal testing in maternal plasma. 61
32190123 2020
5
Symptomatic Mandibular Fibrous Dysplasia With Concurrent Triple X- and Premutation Stage Fragile-X-Syndrome: Case Report With Short Literature Survey. 61
31810942 2019
6
47, XXX syndrome with infertility, premature ovarian insufficiency, and streak ovaries. 61
31183102 2019
7
Non-invasive prenatal testing for detection of trisomy 13, 18, 21 and sex chromosome aneuploidies in 8594 cases. 61
31165466 2019
8
Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies. 61
30127341 2019
9
Changes in the cohort composition of turner syndrome and severe non-diagnosis of Klinefelter, 47,XXX and 47,XYY syndrome: a nationwide cohort study. 61
30642344 2019
10
Identification of paternal uniparental disomy on chromosome 22 and a de novo deletion on chromosome 18 in individuals with orofacial clefts. 61
30141273 2018
11
Behavioral and psychological features in girls and women with triple-X syndrome. 61
30070765 2018
12
Novel biallelic ATM mutations coexist with a mosaic form of triple X syndrome in an 11-year-old girl at remission after T cell acute leukemia. 61
29492593 2018
13
Vocal and gestural productions of 24-month-old children with sex chromosome trisomies. 61
28726283 2018
14
Genomics-based non-invasive prenatal testing for detection of fetal chromosomal aneuploidy in pregnant women. 61
29125628 2017
15
Sex chromosome aneuploidies and copy-number variants: a further explanation for neurodevelopmental prognosis variability? 61
28612834 2017
16
Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient. 61
28925367 2017
17
A finding in genetic polymorphism analysis study: A case of non-mosaic 47, XXX without manifestations. 61
28697408 2017
18
Detection of Turner syndrome using X-chromosome inactivation specific differentially methylated CpG sites: A pilot study. 61
28284085 2017
19
Noninvasive prenatal screening for fetal common sex chromosome aneuploidies from maternal blood. 61
28357876 2017
20
Cross-sectional study shows that impaired bone mineral status and metabolism are found in nonmosaic triple X syndrome. 61
28090675 2017
21
Gender balance in patients with systemic lupus erythematosus. 61
28137478 2017
22
Expanding the phenotype of Triple X syndrome: A comparison of prenatal versus postnatal diagnosis. 61
27644018 2016
23
Triple X syndrome and puberty: focus on the hypothalamus-hypophysis-gonad axis. 61
26952785 2016
24
High Myopia Associated with Triple X Syndrome. 61
27928398 2016
25
Cytogenetic studies of 1232 patients with different sexual development abnormalities from the Sultanate of Oman. 61
26706459 2016
26
Over-expression of XIST, the Master Gene for X Chromosome Inactivation, in Females With Major Affective Disorders. 61
26425698 2015
27
The Turner syndrome in patient with 45X/47XXX mosaic karyotype--case report. 61
25826153 2015
28
45,X/47,XXX Mosaicism and Short Stature. 61
26137340 2015
29
A case-control study of brain structure and behavioral characteristics in 47,XXX syndrome. 61
25287572 2014
30
Bladder exstrophy-epispadias complex and triple-X syndrome: incidental finding or causality? 61
25200913 2014
31
Structural and numerical changes of chromosome X in patients with esophageal atresia. 61
24398799 2014
32
A case associated with comorbidities among cerebral infarction, idiopathic thrombocytopenic purpura, and triple x syndrome. 61
25035678 2014
33
Craniofacial and dental manifestations of triple X syndrome associated with congenital hypothyroidism: a case report. 61
24117978 2014
34
Poor socio-economic status in 47,XXX --an unexpected effect of an extra X chromosome. 61
23542668 2013
35
Cytogenetic evaluation of patients with clinical spectrum of Turner syndrome. 61
24082654 2013
36
Fetal axillary cystic hygroma: a novel association with triple X syndrome. 61
23109196 2012
37
Triple x syndrome with short stature: case report and literature review. 61
23056899 2012
38
Mosaic triple X syndrome in a female with primary amenorrhea. 61
23162306 2012
39
Autism in association with Triple X syndrome. 61
22311144 2012
40
Triple X syndrome. 61
22755288 2012
41
The psychiatric phenotype in triple X syndrome: new hypotheses illustrated in two cases. 61
22582855 2012
42
Gilles de la Tourette's syndrome in a patient with 47(XXX) syndrome: a case report. 61
22054059 2011
43
Premature ovarian aging in primary infertility: Triple X syndrome. 61
22346085 2011
44
GM1 gangliosidosis and Morquio B disease: an update on genetic alterations and clinical findings. 61
21497194 2011
45
Application of microsatellite loci on the chromosome X for rapid prenatal detection of the chromosome X numerical abnormalities. 61
21674836 2011
46
Maternal de novo triple mosaicism for two single OCRL nucleotide substitutions (c.1736A>T, c.1736A>G) in a Lowe syndrome family. 61
21225285 2011
47
Triple X syndrome: characteristics of 42 Italian girls and parental emotional response to prenatal diagnosis. 61
20473517 2010
48
Human embryonic stem cells as models for aneuploid chromosomal syndromes. 61
20641042 2010
49
Triple X syndrome: a review of the literature. 61
19568271 2010
50
Mortality and incidence in women with 47,XXX and variants. 61
20101696 2010
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Variations for Triple X Syndrome

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Expression for Triple X Syndrome

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Search GEO for disease gene expression data for Triple X Syndrome.
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Pathways for Triple X Syndrome

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GO Terms for Triple X Syndrome

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Sources for Triple X Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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