MCID: TRC015
MIFTS: 27

Trochlear Nerve Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Trochlear Nerve Disease

MalaCards integrated aliases for Trochlear Nerve Disease:

Name: Trochlear Nerve Disease 12 15 17
Trochlear Nerve Diseases 43 71
Superior Oblique Muscle Innervation Disorder 12
Fourth Cranial Nerve Paresis 71
Disorder of Trochlear Nerve 12
Trochlear Nerve Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13864
ICD9CM 34 378.53
MeSH 43 D020432
NCIt 49 C78395
ICD10 32 H49.1
UMLS 71 C0271375 C0423092 C0751939 more

Summaries for Trochlear Nerve Disease

MalaCards based summary : Trochlear Nerve Disease, also known as trochlear nerve diseases, is related to rare trochlear nerve disorder and pityriasis rosea. An important gene associated with Trochlear Nerve Disease is KRTAP10-8 (Keratin Associated Protein 10-8), and among its related pathways/superpathways are Developmental Biology and Interferon gamma signaling. Affiliated tissues include eye.

Wikipedia : 74 The trochlear nerve, also called the fourth cranial nerve or CN IV, is a motor nerve (a somatic efferent... more...

Related Diseases for Trochlear Nerve Disease

Diseases in the Trochlear Nerve Disease family:

Rare Trochlear Nerve Disorder

Diseases related to Trochlear Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 rare trochlear nerve disorder 12.4
2 pityriasis rosea 9.6 HLA-DRB5 HLA-DRB1
3 alveolar echinococcosis 9.6 HLA-DRB5 HLA-DRB1
4 focal epithelial hyperplasia 9.6 KRT14 HLA-DRB1
5 limited scleroderma 9.2 TRIM21 HLA-DRB1
6 vulvitis 9.2 KRTAP9-8 KRTAP4-4 KRTAP4-11 KRTAP12-3 KRTAP10-8 KRTAP10-7
7 systemic lupus erythematosus 8.3 TRIM21 SLAMF1 SERPINE1 HLA-DRB5 HLA-DRB1

Comorbidity relations with Trochlear Nerve Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Trochlear Nerve Disease:



Diseases related to Trochlear Nerve Disease

Symptoms & Phenotypes for Trochlear Nerve Disease

Drugs & Therapeutics for Trochlear Nerve Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
2 Measuring Cyclotorsion on Scanning Laser Ophthalmoscopy (SLO)-Fundus Photographs Using the Integrated Algorithm by Heidelberg Spectralis Completed NCT02631369
3 A Randomized Trial of Ocular Electroacupuncture for Trochlear Nerve Palsy Recruiting NCT03099473
4 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
5 A Retrospective Study to Investigate the Efficacy and Relative Factors of Ocular Acupuncture in Ocular Motor Nerve Palsy Patients Not yet recruiting NCT03461809

Search NIH Clinical Center for Trochlear Nerve Disease

Cochrane evidence based reviews: trochlear nerve diseases

Genetic Tests for Trochlear Nerve Disease

Anatomical Context for Trochlear Nerve Disease

MalaCards organs/tissues related to Trochlear Nerve Disease:

40
Eye

Publications for Trochlear Nerve Disease

Articles related to Trochlear Nerve Disease:

# Title Authors PMID Year
1
Clinical course and characteristics of acute presentation of fourth nerve paresis. 61
22800797 2012
2
Alfred Bielschowsky's 1940 legacy for neuro-ophthalmology. 61
9736210 1998
3
Recurrent subtemporal epidural hematoma with second, third and fourth cranial nerve compression. 61
6697706 1984

Variations for Trochlear Nerve Disease

Expression for Trochlear Nerve Disease

Search GEO for disease gene expression data for Trochlear Nerve Disease.

Pathways for Trochlear Nerve Disease

Pathways related to Trochlear Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 KRTAP9-8 KRTAP4-4 KRTAP4-11 KRTAP12-3 KRTAP10-8 KRTAP10-7
2
Show member pathways
11.99 TRIM21 HLA-DRB5 HLA-DRB1
3
Show member pathways
11.62 KRTAP9-8 KRTAP4-4 KRTAP4-11 KRTAP12-3 KRTAP10-8 KRTAP10-7
4 11.31 KRT14 HLA-DRB5 HLA-DRB1
5
Show member pathways
11.22 HLA-DRB5 HLA-DRB1

GO Terms for Trochlear Nerve Disease

Cellular components related to Trochlear Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.5 KRTAP9-8 KRTAP4-4 KRTAP4-11 KRTAP12-3 KRTAP10-8 KRTAP10-7
2 ER to Golgi transport vesicle membrane GO:0012507 9.4 HLA-DRB5 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.37 HLA-DRB5 HLA-DRB1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.32 HLA-DRB5 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DRB5 HLA-DRB1
6 keratin filament GO:0045095 9.17 KRTAP9-8 KRTAP4-4 KRTAP4-11 KRTAP12-3 KRTAP10-8 KRTAP10-7
7 MHC class II protein complex GO:0042613 9.16 HLA-DRB5 HLA-DRB1

Biological processes related to Trochlear Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation GO:0019882 9.26 HLA-DRB5 HLA-DRB1
2 keratinization GO:0031424 9.17 KRTAP9-8 KRTAP4-4 KRTAP4-11 KRTAP12-3 KRTAP10-8 KRTAP10-7
3 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.16 HLA-DRB5 HLA-DRB1
4 interferon-gamma-mediated signaling pathway GO:0060333 9.13 TRIM21 HLA-DRB5 HLA-DRB1

Molecular functions related to Trochlear Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-DRB5 HLA-DRB1

Sources for Trochlear Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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