MCID: TRP005
MIFTS: 39

Trophoblastic Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Trophoblastic Neoplasm

MalaCards integrated aliases for Trophoblastic Neoplasm:

Name: Trophoblastic Neoplasm 12 15
Trophoblastic Neoplasms 73 44 70
Trophoblastic Tumor 12 73 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4085
MeSH 44 D014328
NCIt 50 C3422
SNOMED-CT 67 115234004
UMLS 70 C0041182

Summaries for Trophoblastic Neoplasm

Disease Ontology : 12 A germ cell and embryonal cancer that derives from trophoblastic tissue.

MalaCards based summary : Trophoblastic Neoplasm, also known as trophoblastic neoplasms, is related to epithelioid trophoblastic tumor and testicular trophoblastic tumor. An important gene associated with Trophoblastic Neoplasm is H19 (H19 Imprinted Maternally Expressed Transcript). The drugs Etoposide and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include placenta, uterus and cervix, and related phenotype is reproductive system.

Wikipedia : 73 Gestational trophoblastic disease (GTD) is a term used for a group of pregnancy-related tumours. These... more...

Related Diseases for Trophoblastic Neoplasm

Diseases related to Trophoblastic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 epithelioid trophoblastic tumor 32.6 LGALS1 INHA CSH2 CSH1
2 testicular trophoblastic tumor 32.5 CSH2 CSH1
3 recurrent hydatidiform mole 32.2 NLRP7 KHDC3L
4 placental site trophoblastic tumor 31.8 LNPEP LGALS1 INHA CSH2 CSH1 CGB5
5 gestational trophoblastic neoplasm 31.2 NLRP7 NLRP5 NLRP2 LGALS1 KHDC3L HYMAI
6 ectopic pregnancy 31.0 LGALS1 CGB5 CGA
7 partial hydatidiform mole 30.7 NLRP7 KHDC3L
8 gestational choriocarcinoma 30.5 NLRP7 H19 CSH2 CSH1
9 seminoma 30.3 NLRP7 INHA CGB5 CGA
10 triploidy 30.2 NLRP7 KHDC3L CGA
11 pre-eclampsia 30.1 LNPEP INHA H19 CSH2 CSH1
12 placenta praevia 30.1 CSH2 CSH1
13 hydatidiform mole, recurrent, 1 30.0 NLRP7 KHDC3L INHA H19 CGB5 CGA
14 choriocarcinoma 29.8 LNPEP H19 CSH2 CSH1 CGB5 CGA
15 amenorrhea 10.6
16 invasive mole 10.5
17 rare tumor 10.4
18 teratoma 10.4
19 germ cells tumors 10.3
20 gestational ovarian choriocarcinoma 10.3 CSH2 CSH1
21 choriocarcinoma of the testis 10.3 CSH2 CSH1
22 choriocarcinoma of ovary 10.3 CSH2 CSH1
23 hemihyperplasia, isolated 10.3 H19 CDKN1C
24 non-gestational ovarian choriocarcinoma 10.3 CSH2 CSH1
25 anorchia 10.3 CGB5 CGA
26 germinoma 10.3 INHA CGB5 CGA
27 rh isoimmunization 10.3 CSH2 CSH1
28 gynecomastia 10.3 INHA CGB5 CGA
29 supine hypotensive syndrome 10.3 CSH2 CSH1
30 non-gestational choriocarcinoma 10.3 CSH2 CSH1
31 umbilical hernia 10.2 HYMAI H19 CDKN1C
32 rete ovarii adenoma 10.2 CSH2 CSH1
33 rete ovarii benign neoplasm 10.2 CSH2 CSH1
34 noonan syndrome with multiple lentigines 10.2 RASA2 RASA1 CSH2
35 wilms tumor predisposition 10.2 H19 CDKN1C
36 germ cell and embryonal cancer 10.2 NLRP7 KHDC3L CSH2 CSH1
37 suppressor of tumorigenicity 3 10.1
38 leiomyoma 10.1
39 adrenal cortical carcinoma 10.1 MIR675 INHA H19 CDKN1C
40 mayer-rokitansky-kuster-hauser syndrome 10.1 TP63 H19
41 testicular germ cell tumor 10.1
42 pneumothorax 10.1
43 endodermal sinus tumor 10.1
44 pulmonary tuberculosis 10.1
45 embryonal carcinoma 10.1
46 vaginal discharge 10.1
47 testicular yolk sac tumor 10.1
48 mixed germ cell tumor 10.1
49 thrombotic microangiopathy 10.1
50 pseudohypoparathyroidism, type ib 10.0 NLRP7 NLRP5 NLRP2 KHDC3L CGA

Graphical network of the top 20 diseases related to Trophoblastic Neoplasm:



Diseases related to Trophoblastic Neoplasm

Symptoms & Phenotypes for Trophoblastic Neoplasm

MGI Mouse Phenotypes related to Trophoblastic Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.28 CGA GAL INHA KHDC3L LGALS1 LNPEP

Drugs & Therapeutics for Trophoblastic Neoplasm

Drugs for Trophoblastic Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 124)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3 33419-42-0 36462
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
4
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
5
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
6
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2 149436
7
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
8
leucovorin Approved Phase 3 58-05-9 6006
9
Nitroglycerin Approved, Investigational Phase 2, Phase 3 55-63-0 4510
10
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
11
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
12
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
13
Polyestradiol phosphate Approved Phase 3 28014-46-2
14
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
15
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
16
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
17
Folic acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
18 Tubulin Modulators Phase 3
19 Etoposide phosphate Phase 3
20 Antimitotic Agents Phase 3
21 Albumin-Bound Paclitaxel Phase 3
22 Antidotes Phase 3
23 Nutrients Phase 3
24 Micronutrients Phase 3
25 Trace Elements Phase 3
26 Hematinics Phase 2, Phase 3
27 Protective Agents Phase 3
28 Vitamins Phase 3
29 Liver Extracts Phase 2, Phase 3
30 Calcium, Dietary Phase 3
31 Hormones Phase 3
32 Radiation-Protective Agents Phase 3
33 Cactinomycin Phase 3
34 Vitamin B9 Phase 2, Phase 3
35 Folic Acid Antagonists Phase 2, Phase 3
36 Vitamin B Complex Phase 2, Phase 3
37 Folate Phase 2, Phase 3
38 Antibiotics, Antitubercular Phase 2, Phase 3
39 Antirheumatic Agents Phase 2, Phase 3
40 Immunosuppressive Agents Phase 2, Phase 3
41 Immunologic Factors Phase 2, Phase 3
42 Dermatologic Agents Phase 2, Phase 3
43 Antimetabolites Phase 2, Phase 3
44 Anti-Bacterial Agents Phase 3
45 Anti-Infective Agents Phase 3
46 Estradiol 3-benzoate Phase 3
47 Contraceptive Agents Phase 3
48 Contraceptives, Oral Phase 3
49 Contraceptives, Oral, Combined Phase 3
50 Estradiol 17 beta-cypionate Phase 3

Interventional clinical trials:

(show all 43)
# Name Status NCT ID Phase Drugs
1 A Prospective Randomized Multicenter Clinical Control Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Unknown status NCT02639650 Phase 3 Etoposide;actinomycin D;methotrexate;vincristine;cyclophosphamide;Paclitaxel;Cisplatin;Carboplatin
2 Primary Surgery Plus Single Course Methotrexate Versus Primary Methotrexate for Treatment of Gestational Trophoblastic Neoplasms in Low Risk Cases Above 40y: a Randomized Controled Trial Unknown status NCT02606539 Phase 2, Phase 3 Methotrexate plus folinic acid alone
3 A Phase III Randomized Trial of Pulse Actinomycin-D Versus Multi-day Methotrexate for the Treatment of Low-Risk Gestational Trophoblastic Neoplasia Unknown status NCT01535053 Phase 3 Leucovorin Calcium;Methotrexate
4 A Randomized Phase III Trial of Amifostine vs. No Treatment for Platinum Induced Peripheral Neuropathy Completed NCT00058071 Phase 3 amifostine trihydrate
5 A Randomized Phase III Trial of Weekly Parenteral Methotrexate Versus "Pulsed" Dactinomycin as Primary Management for Low Risk Gestational Trophoblastic Neoplasia Completed NCT00003702 Phase 3 Methotrexate
6 Women's Hospital, Zhejiang University School of Medicine Recruiting NCT03885388 Phase 2, Phase 3 MTX;MTX+ACTD
7 Impact of Second Uterine Evacuation in Women With Non-metastatic, Low-risk Gestational Trophoblastic Neoplasia: A Phase III Trial Recruiting NCT04756713 Phase 3 Chemotherapy
8 A Multicenter, Prospective, Randomized Trial of Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01823315 Phase 3 MTX 1;MTX 2
9 Randomized, Double Blinded, Placebo-Controlled Trial of Antibacterial Prophylaxis for the Prevention of Bacterial Infections in the Post-Engraftment Phase After Allogeneic Hematopoeitic Stem Cell Transplantation Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
10 A Phase II Trial of Pemetrexed (Alimta) in the Treatment of Recurrent or Persistent Low Risk Gestational Trophoblastic Tumor Completed NCT00190918 Phase 2 Pemetrexed
11 Pulse Actinomycin-D as Salvage Therapy for Failed Low Risk Gestational Trophoblastic Neoplasia Completed NCT00003688 Phase 2
12 Oral Beclomethasone Dipropionate Capsules for Treatment of Intestinal Graft-Versus-Host Disease: Compassionate Use in Patients With Contraindictions to High-Dose Immunosuppressive Therapy Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
13 Cytokine-Based Immunotherapy Following High-Dose Chemotherapy and Autologous Stem Cell Transplantation Completed NCT00003408 Phase 2
14 Phase II Clinical Trial Incorporating Alemtuzumab (Campath-1H) in Combination With FK506 and Methylprednisolone for Treatment of Severe Acute Graft vs Host Disease Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
15 Donor Lymphocyte Infusion (DLI) as Adoptive Immunotherapy for Relapse Malignancies After Allogeneic Hematopoietic Transplantation Completed NCT00003887 Phase 2
16 Psychosexual Intervention for Gynecologic and Breast Cancer Patients Completed NCT01764802 Phase 2
17 A Phase II Study to Evaluate Low-Dose Alemtuzumab as a Glucocorticoid-Sparing Agent for Initial Systemic Treatment of Acute Graft-Versus-Host Disease Completed NCT00410657 Phase 2 methylprednisolone;prednisone
18 A Phase I-II Safety, Tolerability And Pharmacokinetic Study Of Ravuconazole For Prophylaxis Of Invasive Fungal Infections In Patients Undergoing Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2 ravuconazole
19 Combination of Interleukin 11 (Neumega) With G-CSF to Mobilize Autologous Peripheral Blood Stem Cells (PBSC) Completed NCT00004157 Phase 2
20 Prevention of DMSO-Related Nausea and Vomiting by Prophylactic Administration of Ondansetron for Patients Receiving Autologous Cryopreserved Peripheral Blood Stem Cells Completed NCT00795769 Phase 2 ondansetron
21 A Phase II Study to Determine the Response to Second Curettage as Initial Management for Persistent Low Risk, Non-metastatic Gestational Trophoblastic Neoplasia Completed NCT00521118 Phase 2
22 DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors Recruiting NCT02834013 Phase 2
23 A Phase 2A Study of TRC105 (With Option to Add Bevacizumab) in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Terminated NCT02664961 Phase 2 TRC105;Bevacizumab
24 A Phase II Trial of Pemetrexed (ALIMTA®, LY231514, IND #40061) as Salvage Therapy for Failed Low Risk Gestational Trophoblastic Tumor Terminated NCT00096187 Phase 2 pemetrexed disodium
25 Deferasirox Treatment and Labile Plasma Iron in Iron Overloaded Patients Who Have Undergone Allogeneic Hematopoietic Stem Cell Transplantation Terminated NCT01159067 Phase 2 deferasirox
26 A Phase I Trial of Recombinant Human Interleukin-12 After High-Dose Therapy and Autologous Hematopoietic Stem Cell Support Completed NCT00003107 Phase 1
27 Prolonged Infusion Compared to Standard Infusion Cefepime as Empiric Treatment of Febrile Neutropenia: A Pilot Study Completed NCT01484015 Phase 1 cefepime hydrochloride
28 Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Persistent Gestational Trophoblastic Tumors Using Atomic Force Microscopy and Dual Polarisation Interferometry Unknown status NCT00294177
29 Detection of Minimal Amount of Human Chorionic Gonadotropin by Interferometry in Gestational Trophoblastic Disease Unknown status NCT00166790 chemotherapy agents
30 Prediction of Chemoresistance in Patients Treated for Gestational Trophoblastic Tumors Unknown status NCT03488901
31 A Pilot Study to Evaluate the Potential Efficacy of Lithium Carbonate for Stimulation of Intestinal Recovery In Patients With Acute Graft-versus-host Disease (GVHD) Completed NCT00408681 lithium carbonate
32 Emotional Needs of Caregivers and Patient/Spouse Couples During Hematopoietic Stem Cell Transplantation (HSCT) Completed NCT00082654
33 A Biobehavioral Intervention for Patients With Gynecologic or Breast Cancer Recurrence Completed NCT01764789
34 Pilot Study Evaluating Aprepitant (MK-869) for Prevention of Nausea & Vomiting Secondary to High Dose Cyclophosphamide Administered to Patients Underging Undergoing Peripheral Hematopoietic Progenitor Cell Mobilization Prior to Autologous Transplantation Completed NCT00293384 Aprepitant;Cyclophosphamide;Dexamethasone;Granisetron hydrochloride
35 Randomized-Controlled, Pilot Study of the Effects of a Brief, Scripted Sexual Health Intervention on Sexual Function for Women With Gynecologic Cancer Completed NCT02096783
36 Acquisition of Human Gynecologic Specimens to be Used in Studying the Causes, Diagnosis, Prevention and Treatment of Cancer Completed NCT00897442
37 Tissue Bank for Studies Related to Graft-Versus-Host Disease (GVHD) Completed NCT00900406
38 A Prospective,Multicenter,Randomized Trial of Biweekly Single-dose Actinomycin-D Versus Multi-day Methotrexate Protocol for the Treatment of Low-risk Gestational Trophoblastic Neoplasia Recruiting NCT04562558 Methotrexate;Leucovorin;Dactinomycin
39 The French National Reference Centre of Gestational Trophoblastic Disease Recruiting NCT02892877
40 The Registry of Oncology Outcomes Associated With Testing and Treatment (ROOT) Not yet recruiting NCT04028479 Systemic Treatment (T)
41 Substance P Follow-up to a Pilot Study of Aprepitant vs Placebo Combined With Standard Antiemetics for the Control of Nausea and Vomiting During Hematopoietic Cell Transplantation Terminated NCT00900068
42 Regulatory T Cells at Engraftment as Predictors of Acute Graft-Versus-Host Disease Outcomes in Patients Undergoing Allogeneic Stem Cell Transplantation Terminated NCT00651716
43 Pilot Study of Mechanical Stimulation for Prevention of Hematopoietic Cell Transplant Associated Bone Density Loss Withdrawn NCT01558778

Search NIH Clinical Center for Trophoblastic Neoplasm

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Etoposide
etoposide phosphate
Methotrexate
Methotrexate Sodium

Cochrane evidence based reviews: trophoblastic neoplasms

Genetic Tests for Trophoblastic Neoplasm

Anatomical Context for Trophoblastic Neoplasm

MalaCards organs/tissues related to Trophoblastic Neoplasm:

40
Placenta, Uterus, Cervix, Testis, Thyroid, Bone, Liver

Publications for Trophoblastic Neoplasm

Articles related to Trophoblastic Neoplasm:

(show top 50) (show all 903)
# Title Authors PMID Year
1
Current issues in the histopathology of gestational trophoblastic tumors. 61 54
20055562 2010
2
The expression and diagnostic utility of p63 in the female genital tract. 61 54
19700941 2009
3
Placental site trophoblastic tumor. 61 54
17701427 2008
4
Selecting an appropriate hCG test for managing gestational trophoblastic disease and cancer. 61 54
15305826 2004
5
[Expression of RFC2 and PCNA in different gestational trophoblastic diseases]. 61 54
14960244 2004
6
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells. 61 54
14691298 2003
7
Persistent low levels of human chorionic gonadotropin: A premalignant gestational trophoblastic disease. 54 61
12748494 2003
8
Serum levels of macrophage colony-stimulating factor in trophoblastic disease. 61 54
11263936 2001
9
Cellular responses to sodium butyrate exhibit the dominance of one parental phenotype in somatic cell hybrids. 61 54
11032754 2000
10
Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. 61 54
1661266 1991
11
Epithelioid trophoblastic tumor presenting as a Caesarean scar defect: A case report. 61
33604444 2021
12
Uterine rupture and shock: an unusual presentation of gestational trophoblastic neoplasm. 61
33713681 2021
13
PLAC8 promotes the autophagic activity and improves the growth priority of human trophoblast cells. 61
33570788 2021
14
Total laparoscopic hysterectomy in combination with dilation and evacuation of an 18-week-sized uterus with gestational trophoblastic neoplasia: a novel treatment approach. 61
33197418 2021
15
Fertility and pregnancy outcome in gestational trophoblastic disease. 61
33649007 2021
16
"It's not lupus". A placental site trophoblastic tumor presenting as a lupus-like paraneoplastic syndrome. A grand round case. 61
33407043 2021
17
Gestational trophoblastic neoplasia: Novelties and challenges. 61
33685753 2021
18
CD133 Expression in Placenta Chorioangioma Presenting as a Giant Asymptomatic Mass. 61
33670362 2021
19
Directive clinique no 408 : Prise en charge des maladies gestationnelles trophoblastiques. 61
33384137 2021
20
Guideline No. 408: Management of Gestational Trophoblastic Diseases. 61
33384141 2021
21
Clinical presentation and diagnosis of Gestational Trophoblastic Disease. 61
33422446 2020
22
Tumor-suppressive function of methiothepin in human placental choriocarcinoma cells. 61
33112774 2020
23
Cystic Trophoblastic Tumor in a Primary Central Nervous System Post-Chemotherapy Germ Cell Tumor: The First Case Report. 61
32498578 2020
24
Double trouble: Extrauterine epithelioid trophoblastic tumor with uterine choriocarcinoma - An autopsy report. 61
33078754 2020
25
Epithelioid trophoblastic tumor coexisting with choriocarcinoma around an abdominal wall cesarean scar: a case report and review of the literature. 61
33012293 2020
26
Choriocarcinoma with lumbar muscle metastases: A case report. 61
33195679 2020
27
People living with human immunodeficiency virus and gestational trophoblastic neoplasm. 61
33176993 2020
28
Tubal choriocarcinoma presented as ruptured ectopic pregnancy: a case report and review of the literature. 61
32919475 2020
29
Epithelioid trophoblastic tumor that requires fertility preservation: A case report and review of literature. 61
32917327 2020
30
Hemoptysis as the first symptom in the diagnosis of metastatic choriocarcinoma in the third trimester of pregnancy: A case report. 61
32426244 2020
31
MiR-384 inhibits proliferation and migration of trophoblast cells via targeting PTBP3. 61
32512528 2020
32
Pleomorphic Undifferentiated Uterine Sarcoma in a Young Patient Presenting With Elevated Beta-hCG and Rare Variants of Benign Leiomyoma: A Case Report and Review of the Literature. 61
31033798 2020
33
[Preliminary study of PD-1 inhibitor in the treatment of drug-resistant recurrent gestational trophoblastic neoplasia]. 61
32842245 2020
34
Successful pregnancy in a cancer patient previously cured of a gestational trophoblastic tumor by immunotherapy. 61
32171750 2020
35
Placental site trophoblastic tumor: Successful treatment of 13 cases. 61
32274412 2020
36
A Rare Case of Atypical Placental Site Nodule With an Emerging Intermediate Trophoblastic Tumor. 61
30829757 2020
37
Differential expression of SALL4 in CTCs derived from hydatidiform moles and gestational trophoblastic neoplasms. 61
32187420 2020
38
Whole transcriptome analysis of gestational trophoblastic neoplasms reveals altered PI3K signaling pathway in epithelioid trophoblastic tumor. 61
31954539 2020
39
Ovarian Intermediate Trophoblastic Tumors: Genotyping Defines a Distinct Category of Nongestational Tumors of Germ Cell Type. 61
31688005 2020
40
A review on management of gestational trophoblastic neoplasia. 61
32509606 2020
41
Epithelioid trophoblastic tumor in a postmenopausal woman: A case report and review of the literature in the postmenopausal group. 61
32108639 2020
42
lnc003875/miR-363/EGR1 regulatory network in the carcinoma -associated fibroblasts controls the angiogenesis of human placental site trophoblastic tumor (PSTT). 61
31857113 2020
43
Epithelioid Trophoblastic Tumor: Expanding the Clinicopathologic Spectrum of a Rare Malignancy. 61
30480644 2020
44
Placental site trophoblastic disease. 61
31699803 2020
45
Recurrent Thyroid Storm Caused by a Complete Hydatidiform Mole in a Perimenopausal Woman. 61
33425402 2020
46
Cystic trophoblastic tumor - The effect of chemotherapy in metastatic testicular germ cell tumor to retroperitoneal lymph nodes. 61
32015622 2020
47
Gestational Trophoblastic Neoplasia, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology. 61
31693991 2019
48
Keratoacanthoma-like nodules as first manifestation of metastatic epithelioid trophoblastic tumor. 61
31735008 2019
49
Choriocarcinoma After Normal Vaginal Delivery; A Rare Entity. 61
31933325 2019
50
Laterally Extended Endopelvic Resection of Recurrent Epithelioid Trophoblastic Tumor by Laparoscopy. 61
31125723 2019

Variations for Trophoblastic Neoplasm

Expression for Trophoblastic Neoplasm

Search GEO for disease gene expression data for Trophoblastic Neoplasm.

Pathways for Trophoblastic Neoplasm

GO Terms for Trophoblastic Neoplasm

Cellular components related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 LNPEP LGALS1 INHA GAL CSH2 CSH1

Biological processes related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.01 RASA2 RASA1 LNPEP INHA CSH2 CSH1
2 skeletal system development GO:0001501 9.7 TP63 INHA CNMD
3 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.51 MIR675 H19
4 negative regulation of Ras protein signal transduction GO:0046580 9.49 RASA2 RASA1
5 animal organ development GO:0048513 9.48 CSH2 CSH1
6 peptide hormone processing GO:0016486 9.46 CGB5 CGA
7 negative regulation of phosphorylation GO:0042326 9.43 INHA CDKN1C
8 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.37 MIR675 H19
9 growth hormone receptor signaling pathway GO:0060396 9.32 CSH2 CSH1
10 positive regulation of growth GO:0045927 9.26 CSH2 CSH1
11 negative regulation of ATP biosynthetic process GO:2001170 9.16 MIR675 H19
12 negative regulation of superoxide dismutase activity GO:1901670 8.96 MIR675 H19
13 positive regulation of hepatocyte apoptotic process GO:1903945 8.62 MIR675 H19

Molecular functions related to Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 INHA GAL CSH2 CSH1 CGB5 CGA
2 growth hormone receptor binding GO:0005131 8.96 CSH2 CSH1

Sources for Trophoblastic Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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