TCP
MCID: TRP008
MIFTS: 50

Tropical Calcific Pancreatitis (TCP)

Categories: Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Tropical Calcific Pancreatitis

MalaCards integrated aliases for Tropical Calcific Pancreatitis:

Name: Tropical Calcific Pancreatitis 58 76 38 30 13 6 41 74
Tcp 58 60 76
Fibrocalculous Pancreatic Diabetes 58 74
Fibrocalculous Pancreatic Diabetes, Susceptibility to 58
Tropical Calcific Chronic Pancreatitis 60
Tropical Pancreatitis 60

Characteristics:

Orphanet epidemiological data:

60
tropical pancreatitis
Age of onset: Childhood;

OMIM:

58
Inheritance:
autosomal recessive
autosomal dominant

Miscellaneous:
median age at onset is 21 years
occurs most often in developing countries in tropical regions
no phenotypic difference between patients who are homozygous or heterozygous for mutations in the spink1 gene


HPO:

33
tropical calcific pancreatitis:
Inheritance autosomal dominant inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 58 608189
KEGG 38 H00932
ICD10 via Orphanet 35 K86.1
UMLS via Orphanet 75 C1842402
Orphanet 60 ORPHA103918
MedGen 43 C1842402

Summaries for Tropical Calcific Pancreatitis

UniProtKB/Swiss-Prot : 76 Tropical calcific pancreatitis: Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.

MalaCards based summary : Tropical Calcific Pancreatitis, also known as tcp, is related to alcoholic pancreatitis and pancreatitis. An important gene associated with Tropical Calcific Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Lysosome and Antigen processing and presentation. The drugs Vitamin D and Calcium have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow, and related phenotypes are abdominal pain and neoplasm of the pancreas

Description from OMIM: 608189

Related Diseases for Tropical Calcific Pancreatitis

Diseases related to Tropical Calcific Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 alcoholic pancreatitis 30.0 PRSS1 SPINK1
2 pancreatitis 29.7 CTRC CTSB PRSS1 PRSS2 REG1A SPINK1
3 pancreatitis, hereditary 29.3 CTRC PRSS1 PRSS2 SPINK1
4 fibrocalculous pancreatopathy 12.0
5 cholera 10.4
6 diabetes mellitus 10.3
7 prostate cancer 10.3
8 prostate cancer, hereditary, 8 10.3
9 prostate cancer, hereditary, 6 10.3
10 alzheimer disease 10.2
11 pityriasis rubra pilaris 10.2
12 cervical intraepithelial neoplasia 10.2
13 diabetes mellitus, noninsulin-dependent 10.1
14 cataract 10.1
15 hemiplegia 10.1
16 autonomic neuropathy 10.1
17 neuropathy 10.1
18 small cell cancer of the lung 10.1
19 lung cancer 10.1
20 hypoxia 10.1
21 acute pancreatitis 10.1 CTSB SPINK1
22 pancreatic steatorrhea 10.1 CTSB PRSS1
23 pancreas disease 10.0 PRSS1 SPINK1
24 bone fracture 10.0
25 linitis plastica 10.0 PRSS1 PRSS2
26 celiac disease 1 9.9
27 cystic fibrosis 9.9
28 bone mineral density quantitative trait locus 3 9.9
29 kwashiorkor 9.9
30 adenocarcinoma 9.9
31 recurrent acute pancreatitis 9.9 CTRC PRSS1 SPINK1
32 blood group, colton system 9.9
33 leri-weill dyschondrosteosis 9.9
34 neutrophil migration 9.9
35 rheumatoid arthritis 9.9
36 nasopharyngeal carcinoma 9.9
37 avascular necrosis of femoral head, primary, 1 9.9
38 intraocular pressure quantitative trait locus 9.9
39 gingival recession 9.9
40 osteonecrosis 9.9
41 obstructive nephropathy 9.9
42 osteomyelitis 9.9
43 dentin caries 9.9
44 sarcoma 9.9
45 dementia 9.9
46 status epilepticus 9.9
47 rectum cancer 9.9
48 neuroma 9.9
49 gastroenteritis 9.9
50 oropharynx cancer 9.9

Graphical network of the top 20 diseases related to Tropical Calcific Pancreatitis:



Diseases related to Tropical Calcific Pancreatitis

Symptoms & Phenotypes for Tropical Calcific Pancreatitis

Human phenotypes related to Tropical Calcific Pancreatitis:

33
# Description HPO Frequency HPO Source Accession
1 abdominal pain 33 HP:0002027
2 neoplasm of the pancreas 33 HP:0002894
3 pancreatic calcification 33 HP:0005213
4 chronic pancreatitis 33 HP:0006280
5 insulin-dependent but ketosis-resistant diabetes 33 HP:0008205

Symptoms via clinical synopsis from OMIM:

58
Abdomen Pancreas:
chronic pancreatitis
pancreatic calcifications
intraductal calculi, especially in the caput
increased risk of pancreatic cancer

Neoplasia:
increased risk of pancreatic cancer

Abdomen:
recurrent abdominal pain since childhood

Endocrine Features:
increased incidence of fibrocalculus pancreatic diabetes (fcpd)
insulin-dependent but ketosis-resistant diabetes

Clinical features from OMIM:

608189

MGI Mouse Phenotypes related to Tropical Calcific Pancreatitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 ACE CTSB REG1A SPINK1 TCF7L2

Drugs & Therapeutics for Tropical Calcific Pancreatitis

Drugs for Tropical Calcific Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
4
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
5 Trace Elements Phase 4
6 Nutrients Phase 4
7 Bone Density Conservation Agents Phase 4
8 Ergocalciferols Phase 4
9 Hormones Phase 4
10 Vitamins Phase 4
11 Calcium, Dietary Phase 4
12 Vitamin D2 Phase 4
13 Micronutrients Phase 4
14 Calciferol Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)

Search NIH Clinical Center for Tropical Calcific Pancreatitis

Genetic Tests for Tropical Calcific Pancreatitis

Genetic tests related to Tropical Calcific Pancreatitis:

# Genetic test Affiliating Genes
1 Tropical Calcific Pancreatitis 30 SPINK1

Anatomical Context for Tropical Calcific Pancreatitis

MalaCards organs/tissues related to Tropical Calcific Pancreatitis:

42
Bone, Brain, Bone Marrow, Pancreas, Testes, Neutrophil, Thymus

Publications for Tropical Calcific Pancreatitis

Articles related to Tropical Calcific Pancreatitis:

(show top 50) (show all 930)
# Title Authors Year
1
Comparison of hyper- and hypofractionated radiation schemes with IMRT technique in small cell lung cancer: Clinical outcomes and the introduction of extended LQ and TCP models. ( 31015136 )
2019
2
Local administration of aspirin with β-tricalcium phosphate/poly-lactic-co-glycolic acid (β-TCP/PLGA) could enhance osteoporotic bone regeneration. ( 31076895 )
2019
3
Single-dose local administration of parathyroid hormone (1-34, PTH) with β-tricalcium phosphate/collagen (β-TCP/COL) enhances bone defect healing in ovariectomized rats. ( 29392472 )
2019
4
PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. ( 29655516 )
2019
5
Healing bone lesion defects using injectable CaSO4 /CaPO4 -TCP bone graft substitute compared to cancellous allograft bone chips in a canine model. ( 29663638 )
2019
6
Data-Driven Methods for Stealthy Attacks on TCP/IP-Based Networked Control Systems Equipped With Attack Detectors. ( 29994347 )
2019
7
Escherichia coli-derived BMP-2-absorbed β-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects. ( 30097727 )
2019
8
Collagen/β-TCP nerve guidance conduits promote facial nerve regeneration in mini-swine and the underlying biological mechanism: A pilot in vivo study. ( 30261120 )
2019
9
Association between tobacco prices and smoking onset: evidence from the TCP India Survey. ( 30275169 )
2019
10
Combined treatment with Cinnamaldehyde and β-TCP had an additive effect on bone formation and angiogenesis in critical size calvarial defect in ovariectomized rats. ( 30399593 )
2019
11
Synergistically enhanced osteoconductivity and anti-inflammation of PLGA/β-TCP/Mg(OH)2 composite for orthopedic applications. ( 30423751 )
2019
12
Direct Regulation of the EFR-Dependent Immune Response by Arabidopsis TCP Transcription Factors. ( 30480481 )
2019
13
Evaluation of the Efficacy of a 1:1 Mixture of β-TCP and rhPDGF-BB in the Surgical Management of Two- and Three-Wall Intraosseous Defects: A Prospective Clinical Trial. ( 30543732 )
2019
14
Congestion tracking control for uncertain TCP/AQM network based on integral backstepping. ( 30621910 )
2019
15
TCP transcription factors interact with ZED1-related kinases as components of the temperature-regulated immunity. ( 30652316 )
2019
16
Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect. ( 30660996 )
2019
17
A Systematic Study of the Effect of pH on the Initialization of Ca-deficient Hydroxyapatite to β-TCP Nanoparticles. ( 30678124 )
2019
18
An Approach to Reinforce Multipath TCP with Path-Aware Information. ( 30682810 )
2019
19
Comparative evaluation of chlorpyrifos exposure estimates from whole-body dermal dosimetry and urinary trichloro-2-pyridinol (TCP) methods. ( 30735976 )
2019
20
The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways. ( 30742619 )
2019
21
Engineering Porous β-tricalcium Phosphate (β-TCP) Scaffolds with Multiple Channels to Promote Cell Migration, Proliferation, and Angiogenesis. ( 30758175 )
2019
22
The fast degradation of β-TCP ceramics facilitates healing of bone defects by the combination of BMP-2 and Teriparatide. ( 30784943 )
2019
23
Horizontal Bone Augmentation in the Anterior Esthetic Area of the Maxilla Using a Flap Design Adapted from Mucogingival Surgery in Association with PLA Membrane and β-TCP. ( 30794255 )
2019
24
Osteogenic differentiation of mesenchymal stem cells is enhanced in a 45S5-supplemented β-TCP composite scaffold: an in-vitro comparison of Vitoss and Vitoss BA. ( 30811492 )
2019
25
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties. ( 30813075 )
2019
26
Comprehensive phenotyping reveals interactions and functions of Arabidopsis thaliana TCP genes in yield determination. ( 30903633 )
2019
27
Impact of setup and range uncertainties on TCP and NTCP following VMAT or IMPT of oropharyngeal cancer patients. ( 30921775 )
2019
28
Genome-wide identification of members of the TCP gene family in switchgrass (Panicum virgatum L.) and analysis of their expression. ( 30928363 )
2019
29
3D printed β-TCP scaffold with sphingosine 1-phosphate coating promotes osteogenesis and inhibits inflammation. ( 30929923 )
2019
30
Effect of strontium substituted ß-TCP associated to mesenchymal stem cells from bone marrow and adipose tissue on spinal fusion in healty and ovariectomized rat. ( 30950062 )
2019
31
Alginate/Gelatin Hydrogels Reinforced with TiO₂ and β-TCP Fabricated by Microextrusion-based Printing for Tissue Regeneration. ( 30960441 )
2019
32
Indirect 3D printing technology for the fabrication of customised β-TCP/chitosan scaffold with the shape of rabbit radial head-an in vitro study. ( 30975173 )
2019
33
In Vitro and In Vivo Studies of Hydrophilic Electrospun PLA95/β-TCP Membranes for Guided Tissue Regeneration (GTR) Applications. ( 30979018 )
2019
34
Implementation and characterization of coating pure titanium dental implant with sintered β-TCP by using Nd:YAG laser. ( 30983835 )
2019
35
Storming the Castle with TCP. ( 31000513 )
2019
36
Natural Variations at TIG1 Encoding a TCP Transcription Factor Contribute to Plant Architecture Domestication in Rice. ( 31002981 )
2019
37
Collagen/β-TCP composite as a bone-graft substitute for posterior spinal fusion in rabbit model: a comparison study. ( 31022713 )
2019
38
Fabrication and in vitro dissolution evaluation of low-crystalline β-TCP blocks through aqueous solution mediated phase conversion. ( 31029315 )
2019
39
Parallel Transmission of Distributed Sensor Based on SCTP and TCP for Heterogeneous Wireless Networks in IoT. ( 31035666 )
2019
40
TCP Transcription Factors Associate with PHYTOCHROME INTERACTING FACTOR 4 and CRYPTOCHROME 1 to Regulate Thermomorphogenesis in Arabidopsis thaliana. ( 31078553 )
2019
41
Genome-Wide Analysis of the TCP Gene Family in Switchgrass (Panicum virgatum L.). ( 31093492 )
2019
42
Caries-Preventive Effect of NaF, NaF plus TCP, NaF plus CPP-ACP, and SDF Varnishes on Sound Dentin and Artificial Dentin Caries in vitro. ( 29339648 )
2018
43
mutTCPdb: a comprehensive database for genomic variants of a tropical country neglected disease-tropical calcific pancreatitis. ( 30053238 )
2018
44
The application of PRP combined with TCP in repairing avascular necrosis of the femoral head after femoral neck fracture in rabbit. ( 29509236 )
2018
45
An AT-hook protein DEPRESSED PALEA1 physically interacts with the TCP Family transcription factor RETARDED PALEA1 in rice. ( 29122595 )
2018
46
Adsorption of 1,2,3-Trichloropropane (TCP) to meet a MCL of 5 ppt. ( 29128248 )
2018
47
Transcriptome - Scale characterization of salt responsive bean TCP transcription factors. ( 29129811 )
2018
48
Spatial Control of Gene Expression by miR319-Regulated TCP Transcription Factors in Leaf Development. ( 29133375 )
2018
49
TCP Transcription Factors Regulate Shade Avoidance via Directly Mediating the Expression of Both PHYTOCHROME INTERACTING FACTORs and Auxin Biosynthetic Genes. ( 29254986 )
2018
50
Physico-Mechanical Properties of HA/TCP Pellets and Their Three-Dimensional Biological Evaluation In Vitro. ( 29299875 )
2018

Variations for Tropical Calcific Pancreatitis

UniProtKB/Swiss-Prot genetic disease variations for Tropical Calcific Pancreatitis:

76
# Symbol AA change Variation ID SNP ID
1 SPINK1 p.Asn34Ser VAR_011689 rs17107315

ClinVar genetic disease variations for Tropical Calcific Pancreatitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SPINK1 SPINK1, -215G-T, PROMOTER single nucleotide variant Pathogenic
2 SPINK1 NM_003122.4(SPINK1): c.194+2T> C single nucleotide variant Pathogenic rs148954387 GRCh38 Chromosome 5, 147828020: 147828020
3 SPINK1 NM_003122.4(SPINK1): c.194+2T> C single nucleotide variant Pathogenic rs148954387 GRCh37 Chromosome 5, 147207583: 147207583

Expression for Tropical Calcific Pancreatitis

Search GEO for disease gene expression data for Tropical Calcific Pancreatitis.

Pathways for Tropical Calcific Pancreatitis

Pathways related to Tropical Calcific Pancreatitis according to KEGG:

38
# Name Kegg Source Accession
1 Lysosome hsa04142
2 Antigen processing and presentation hsa04612

GO Terms for Tropical Calcific Pancreatitis

Cellular components related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ACE CTSB PRSS1 PRSS2 REG1A SPINK1
2 extracellular region GO:0005576 9.17 ACE CTRC CTSB PRSS1 PRSS2 REG1A

Biological processes related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein binding GO:0032092 9.37 ACE TCF7L2
2 extracellular matrix disassembly GO:0022617 9.32 PRSS1 PRSS2
3 collagen catabolic process GO:0030574 9.26 CTSB PRSS2
4 digestion GO:0007586 9.16 PRSS1 PRSS2
5 proteolysis GO:0006508 9.02 ACE CTRC CTSB PRSS1 PRSS2
6 cobalamin metabolic process GO:0009235 8.96 CTRC PRSS1

Molecular functions related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.65 ACE CTRC CTSB PRSS1 PRSS2
2 serine-type peptidase activity GO:0008236 9.33 CTRC PRSS1 PRSS2
3 serine-type endopeptidase activity GO:0004252 9.13 CTRC PRSS1 PRSS2
4 peptidase activity GO:0008233 9.02 ACE CTRC CTSB PRSS1 PRSS2

Sources for Tropical Calcific Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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