TCP
MCID: TRP008
MIFTS: 50

Tropical Calcific Pancreatitis (TCP)

Categories: Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Tropical Calcific Pancreatitis

MalaCards integrated aliases for Tropical Calcific Pancreatitis:

Name: Tropical Calcific Pancreatitis 58 76 38 30 13 6 41 74
Tcp 58 60 76
Fibrocalculous Pancreatic Diabetes 58 74
Fibrocalculous Pancreatic Diabetes, Susceptibility to 58
Tropical Calcific Chronic Pancreatitis 60
Tropical Pancreatitis 60

Characteristics:

Orphanet epidemiological data:

60
tropical pancreatitis
Age of onset: Childhood;

OMIM:

58
Inheritance:
autosomal recessive
autosomal dominant

Miscellaneous:
median age at onset is 21 years
occurs most often in developing countries in tropical regions
no phenotypic difference between patients who are homozygous or heterozygous for mutations in the spink1 gene


HPO:

33
tropical calcific pancreatitis:
Inheritance autosomal recessive inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 608189
KEGG 38 H00932
ICD10 via Orphanet 35 K86.1
UMLS via Orphanet 75 C1842402
Orphanet 60 ORPHA103918
MedGen 43 C1842402

Summaries for Tropical Calcific Pancreatitis

UniProtKB/Swiss-Prot : 76 Tropical calcific pancreatitis: Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.

MalaCards based summary : Tropical Calcific Pancreatitis, also known as tcp, is related to alcoholic pancreatitis and pancreatitis. An important gene associated with Tropical Calcific Pancreatitis is SPINK1 (Serine Peptidase Inhibitor, Kazal Type 1), and among its related pathways/superpathways are Lysosome and Antigen processing and presentation. The drugs Ergocalciferol and Vitamin D have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow, and related phenotypes are abdominal pain and neoplasm of the pancreas

Description from OMIM: 608189

Related Diseases for Tropical Calcific Pancreatitis

Diseases related to Tropical Calcific Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 alcoholic pancreatitis 30.0 PRSS1 SPINK1
2 pancreatitis 29.6 CTRC CTSB PRSS1 PRSS2 REG1A SPINK1
3 fibrocalculous pancreatopathy 12.0
4 cholera 10.4
5 diabetes mellitus 10.3
6 prostate cancer 10.3
7 prostate cancer, hereditary, 8 10.3
8 prostate cancer, hereditary, 6 10.3
9 alzheimer disease 10.2
10 pityriasis rubra pilaris 10.2
11 cervical intraepithelial neoplasia 10.2
12 diabetes mellitus, noninsulin-dependent 10.1
13 cataract 10.1
14 hemiplegia 10.1
15 autonomic neuropathy 10.1
16 neuropathy 10.1
17 hypoxia 10.1
18 acute pancreatitis 10.1 CTSB SPINK1
19 pancreatic steatorrhea 10.1 CTSB PRSS1
20 pancreas disease 10.0 PRSS1 SPINK1
21 small cell cancer of the lung 10.0
22 lung cancer 10.0
23 bone fracture 10.0
24 linitis plastica 10.0 PRSS1 PRSS2
25 celiac disease 1 9.9
26 cystic fibrosis 9.9
27 bone mineral density quantitative trait locus 3 9.9
28 kwashiorkor 9.9
29 adenocarcinoma 9.9
30 recurrent acute pancreatitis 9.9 CTRC PRSS1 SPINK1
31 cervical cancer 9.9
32 nasopharyngeal carcinoma 9.9
33 avascular necrosis of femoral head, primary, 1 9.9
34 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.9
35 gingival recession 9.9
36 osteonecrosis 9.9
37 obstructive nephropathy 9.9
38 dentin caries 9.9
39 sarcoma 9.9
40 patulous eustachian tube 9.9
41 dementia 9.9
42 status epilepticus 9.9
43 rectum cancer 9.9
44 neuroma 9.9
45 gastroenteritis 9.9
46 spondyloenchondrodysplasia 9.9
47 depression 9.9
48 rapidly involuting congenital hemangioma 9.9
49 nodular lymphocyte predominant hodgkin lymphoma 9.9
50 pancreatic cancer 9.7

Graphical network of the top 20 diseases related to Tropical Calcific Pancreatitis:



Diseases related to Tropical Calcific Pancreatitis

Symptoms & Phenotypes for Tropical Calcific Pancreatitis

Human phenotypes related to Tropical Calcific Pancreatitis:

33
# Description HPO Frequency HPO Source Accession
1 abdominal pain 33 HP:0002027
2 neoplasm of the pancreas 33 HP:0002894
3 pancreatic calcification 33 HP:0005213
4 chronic pancreatitis 33 HP:0006280
5 insulin-dependent but ketosis-resistant diabetes 33 HP:0008205

Symptoms via clinical synopsis from OMIM:

58
Abdomen Pancreas:
chronic pancreatitis
pancreatic calcifications
intraductal calculi, especially in the caput
increased risk of pancreatic cancer

Neoplasia:
increased risk of pancreatic cancer

Abdomen:
recurrent abdominal pain since childhood

Endocrine Features:
increased incidence of fibrocalculus pancreatic diabetes (fcpd)
insulin-dependent but ketosis-resistant diabetes

Clinical features from OMIM:

608189

MGI Mouse Phenotypes related to Tropical Calcific Pancreatitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.02 ACE CTSB REG1A SPINK1 TCF7L2

Drugs & Therapeutics for Tropical Calcific Pancreatitis

Drugs for Tropical Calcific Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
2
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
3
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
4
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
5 Calciferol Phase 4
6 Bone Density Conservation Agents Phase 4
7 Ergocalciferols Phase 4
8 Vitamin D2 Phase 4
9 Hormones Phase 4
10 Nutrients Phase 4
11 Trace Elements Phase 4
12 Vitamins Phase 4
13 Micronutrients Phase 4
14 Calcium, Dietary Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)

Search NIH Clinical Center for Tropical Calcific Pancreatitis

Genetic Tests for Tropical Calcific Pancreatitis

Genetic tests related to Tropical Calcific Pancreatitis:

# Genetic test Affiliating Genes
1 Tropical Calcific Pancreatitis 30 SPINK1

Anatomical Context for Tropical Calcific Pancreatitis

MalaCards organs/tissues related to Tropical Calcific Pancreatitis:

42
Bone, Brain, Bone Marrow, Pancreas, Prostate, Colon, Cortex

Publications for Tropical Calcific Pancreatitis

Articles related to Tropical Calcific Pancreatitis:

(show top 50) (show all 791)
# Title Authors Year
1
Single-dose local administration of parathyroid hormone (1-34, PTH) with β-tricalcium phosphate/collagen (β-TCP/COL) enhances bone defect healing in ovariectomized rats. ( 29392472 )
2019
2
PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. ( 29655516 )
2019
3
Healing bone lesion defects using injectable CaSO4 /CaPO4 -TCP bone graft substitute compared to cancellous allograft bone chips in a canine model. ( 29663638 )
2019
4
Degradation in vitro and in vivo of β-TCP/MCPM-based premixed calcium phosphate cement. ( 30359856 )
2019
5
Synergistically enhanced osteoconductivity and anti-inflammation of PLGA/β-TCP/Mg(OH)2 composite for orthopedic applications. ( 30423751 )
2019
6
Evaluation of the Efficacy of a 1:1 Mixture of β-TCP and rhPDGF-BB in the Surgical Management of Two- and Three-Wall Intraosseous Defects: A Prospective Clinical Trial. ( 30543732 )
2019
7
Congestion tracking control for uncertain TCP/AQM network based on integral backstepping. ( 30621910 )
2019
8
TCP transcription factors interact with ZED1-related kinases as components of the temperature-regulated immunity. ( 30652316 )
2019
9
Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect. ( 30660996 )
2019
10
A Systematic Study of the Effect of pH on the Initialization of Ca-deficient Hydroxyapatite to β-TCP Nanoparticles. ( 30678124 )
2019
11
An Approach to Reinforce Multipath TCP with Path-Aware Information. ( 30682810 )
2019
12
Comparative evaluation of chlorpyrifos exposure estimates from whole-body dermal dosimetry and urinary trichloro-2-pyridinol (TCP) methods. ( 30735976 )
2019
13
The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways. ( 30742619 )
2019
14
Engineering Porous β-tricalcium Phosphate (β-TCP) Scaffolds with Multiple Channels to Promote Cell Migration, Proliferation, and Angiogenesis. ( 30758175 )
2019
15
The fast degradation of β-TCP ceramics facilitates healing of bone defects by the combination of BMP-2 and Teriparatide. ( 30784943 )
2019
16
Horizontal Bone Augmentation in the Anterior Esthetic Area of the Maxilla Using a Flap Design Adapted from Mucogingival Surgery in Association with PLA Membrane and β-TCP. ( 30794255 )
2019
17
Osteogenic differentiation of mesenchymal stem cells is enhanced in a 45S5-supplemented β-TCP composite scaffold: an in-vitro comparison of Vitoss and Vitoss BA. ( 30811492 )
2019
18
Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties. ( 30813075 )
2019
19
Comprehensive phenotyping reveals interactions and functions of Arabidopsis thaliana TCP genes in yield determination. ( 30903633 )
2019
20
mutTCPdb: a comprehensive database for genomic variants of a tropical country neglected disease-tropical calcific pancreatitis. ( 30053238 )
2018
21
The application of PRP combined with TCP in repairing avascular necrosis of the femoral head after femoral neck fracture in rabbit. ( 29509236 )
2018
22
Physico-Mechanical Properties of HA/TCP Pellets and Their Three-Dimensional Biological Evaluation In Vitro. ( 29299875 )
2018
23
In Vivo Evaluation of 3D-Printed Polycaprolactone Scaffold Implantation Combined with β-TCP Powder for Alveolar Bone Augmentation in a Beagle Defect Model. ( 29401707 )
2018
24
Novel β-TCP Coated Titanium Nanofiber Surface for Enhanced Bone Growth. ( 29448505 )
2018
25
Cultivation of EPC and co-cultivation with MSC on β-TCP granules in vitro is feasible without fibronectin coating but influenced by scaffolds' design. ( 29523894 )
2018
26
Preparation and characterization of gelatin-chitosan-nanoβ-TCP based scaffold for orthopaedic application. ( 29525100 )
2018
27
Genome-Wide Identification and Analysis of TCP Transcription Factors Involved in the Formation of Leafy Head in Chinese Cabbage. ( 29538304 )
2018
28
Injectable Bone Substitute Material on the Basis of β-TCP and Hyaluronan Achieves Complete Bone Regeneration While Undergoing Nearly Complete Degradation. ( 29543928 )
2018
29
Enhanced bone regeneration composite scaffolds of PLLA/β-TCP matrix grafted with gelatin and HAp. ( 29549950 )
2018
30
Integrated Oxidized-Hyaluronic Acid/Collagen Hydrogel with β-TCP Using Proanthocyanidins as a Crosslinker for Drug Delivery. ( 29561754 )
2018
31
Collagen and mPCL-TCP scaffolds induced differential bone regeneration in ovary-intact and ovariectomized rats. ( 29578466 )
2018
32
Soybean TCP transcription factors: Evolution, classification, protein interaction and stress and hormone responsiveness. ( 29579640 )
2018
33
Low-Temperature Deposition Modeling of β-TCP Scaffolds with Controlled Bimodal Porosity. ( 29679321 )
2018
34
Efficacy of rhBMP-2 Loaded PCL/β-TCP/bdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration. ( 29682530 )
2018
35
Hemocompatible and Bioactive Heparin-Loaded PCL-α-TCP Fibrous Membranes for Bone Tissue Engineering. ( 29700984 )
2018
36
Evolution of Darwin's Peloric Gloxinia (Sinningia speciosa) Is Caused by a Null Mutation in a Pleiotropic TCP Gene. ( 29718509 )
2018
37
Stimulation of calvarial bone healing with human bone marrow stromal cells versus inhibition with adipose-tissue stromal cells on nanostructured β-TCP-collagen. ( 29933108 )
2018
38
CIN-TCP transcription factors: Transiting cell proliferation in plants. ( 29934986 )
2018
39
Genome-Wide Identification of TCP Family Transcription Factors in Medicago truncatula Reveals Significant Roles of miR319-Targeted TCPs in Nodule Development. ( 29942322 )
2018
40
Evolutionary diversification of CYC/TB1-like TCP homologs and their recruitment for the control of branching and floral morphology in Papaveraceae (basal eudicots). ( 29949661 )
2018
41
Data-Driven Methods for Stealthy Attacks on TCP/IP-Based Networked Control Systems Equipped With Attack Detectors. ( 29994347 )
2018
42
Effects of solidification cooling rate on the corrosion resistance of a biodegradable β-TCP/Mg-Zn-Ca composite. ( 30007209 )
2018
43
Phytoplasma effector SWP1 induces witches' broom symptom by destabilizing the TCP transcription factor BRANCHED1. ( 30047227 )
2018
44
Preclinical Studies of the Biosafety and Efficacy of Human Bone Marrow Mesenchymal Stem Cells Pre-Seeded into β-TCP Scaffolds after Transplantation. ( 30081464 )
2018
45
Escherichia coli-derived BMP-2-absorbed β-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects. ( 30097727 )
2018
46
TCP Transcription Factors Interact With NPR1 and Contribute Redundantly to Systemic Acquired Resistance. ( 30154809 )
2018
47
A TCP-based early regression index predicts the pathological response in neo-adjuvant radio-chemotherapy of rectal cancer. ( 30196982 )
2018
48
EZH1 Is Associated with TCP-Induced Bone Regeneration through Macrophage Polarization. ( 30228822 )
2018
49
Development of a PCL/gelatin/chitosan/β-TCP electrospun composite for guided bone regeneration. ( 30242739 )
2018
50
Collagen/β-TCP nerve guidance conduits promote facial nerve regeneration in mini-swine and the underlying biological mechanism: A pilot in vivo study. ( 30261120 )
2018

Variations for Tropical Calcific Pancreatitis

UniProtKB/Swiss-Prot genetic disease variations for Tropical Calcific Pancreatitis:

76
# Symbol AA change Variation ID SNP ID
1 SPINK1 p.Asn34Ser VAR_011689 rs17107315

ClinVar genetic disease variations for Tropical Calcific Pancreatitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SPINK1 SPINK1, -215G-T, PROMOTER single nucleotide variant Pathogenic

Expression for Tropical Calcific Pancreatitis

Search GEO for disease gene expression data for Tropical Calcific Pancreatitis.

Pathways for Tropical Calcific Pancreatitis

Pathways related to Tropical Calcific Pancreatitis according to KEGG:

38
# Name Kegg Source Accession
1 Lysosome hsa04142
2 Antigen processing and presentation hsa04612

GO Terms for Tropical Calcific Pancreatitis

Cellular components related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ACE CTSB PRSS1 PRSS2 REG1A SPINK1
2 extracellular region GO:0005576 9.17 ACE CTRC CTSB PRSS1 PRSS2 REG1A

Biological processes related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein binding GO:0032092 9.37 ACE TCF7L2
2 extracellular matrix disassembly GO:0022617 9.32 PRSS1 PRSS2
3 collagen catabolic process GO:0030574 9.26 CTSB PRSS2
4 digestion GO:0007586 9.16 PRSS1 PRSS2
5 proteolysis GO:0006508 9.02 ACE CTRC CTSB PRSS1 PRSS2
6 cobalamin metabolic process GO:0009235 8.96 CTRC PRSS1

Molecular functions related to Tropical Calcific Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.65 ACE CTRC CTSB PRSS1 PRSS2
2 serine-type peptidase activity GO:0008236 9.33 CTRC PRSS1 PRSS2
3 serine-type endopeptidase activity GO:0004252 9.26 CTRC CTSB PRSS1 PRSS2
4 peptidase activity GO:0008233 9.02 ACE CTRC CTSB PRSS1 PRSS2

Sources for Tropical Calcific Pancreatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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