MCID: TRP020
MIFTS: 32

Tropical Endomyocardial Fibrosis

Categories: Rare diseases

Aliases & Classifications for Tropical Endomyocardial Fibrosis

MalaCards integrated aliases for Tropical Endomyocardial Fibrosis:

Name: Tropical Endomyocardial Fibrosis 59
Davies Disease 59
Temf 59

Characteristics:

Orphanet epidemiological data:

59
tropical endomyocardial fibrosis
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood;

Classifications:



External Ids:

Orphanet 59 ORPHA75565
ICD10 via Orphanet 34 I42.3

Summaries for Tropical Endomyocardial Fibrosis

MalaCards based summary : Tropical Endomyocardial Fibrosis, also known as davies disease, is related to endomyocardial fibrosis and schistosomiasis. An important gene associated with Tropical Endomyocardial Fibrosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. Affiliated tissues include skeletal muscle and heart, and related phenotypes are craniofacial and liver/biliary system

Related Diseases for Tropical Endomyocardial Fibrosis

Diseases related to Tropical Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 endomyocardial fibrosis 29.8 IL10 IL4 TNF
2 schistosomiasis 28.7 IL10 IL4 TNF
3 malaria 28.6 IL10 IL4 TNF
4 punctate inner choroidopathy 10.2 IL10 TNF
5 microscopic polyangiitis 10.2 IL10 TNF
6 multifocal choroiditis 10.2 IL10 TNF
7 transient hypogammaglobulinemia 10.2 IL10 TNF
8 choroiditis 10.2 IL10 TNF
9 idiopathic achalasia 10.2 IL10 TNF
10 trichuriasis 10.2 IL10 TNF
11 mucocutaneous leishmaniasis 10.2 IL10 TNF
12 clonorchiasis 10.2 IL10 TNF
13 trachoma 10.2 IL10 TNF
14 listeriosis 10.2 IL10 TNF
15 transverse myelitis 10.2 IL10 TNF
16 intermediate uveitis 10.2 IL10 TNF
17 multidrug-resistant tuberculosis 10.2 IL10 TNF
18 post-transplant lymphoproliferative disease 10.2 IL10 TNF
19 hemorrhagic fever 10.2 IL10 TNF
20 spotted fever 10.2 IL10 TNF
21 hematopoietic stem cell transplantation 10.2 IL10 TNF
22 panuveitis 10.2 IL10 TNF
23 aseptic meningitis 10.2 IL10 TNF
24 scrub typhus 10.2 IL10 TNF
25 cytomegalovirus infection 10.2 IL10 TNF
26 plasmodium vivax malaria 10.2 IL10 TNF
27 q fever 10.2 IL10 TNF
28 lacrimal apparatus disease 10.2 IL10 TNF
29 churg-strauss syndrome 10.2 IL10 TNF
30 severe hemophilia a 10.2 IL10 TNF
31 epstein-barr virus-associated gastric carcinoma 10.2 IL10 TNF
32 lepromatous leprosy 10.2 IL10 TNF
33 hemorrhagic fever with renal syndrome 10.2 IL10 TNF
34 viral encephalitis 10.2 IL10 TNF
35 complex regional pain syndrome 10.2 IL10 TNF
36 idiopathic neutropenia 10.2 IL10 TNF
37 prostatitis 10.2 IL10 TNF
38 mixed connective tissue disease 10.2 IL10 TNF
39 primary progressive multiple sclerosis 10.2 IL10 TNF
40 echinococcosis 10.2 IL10 TNF
41 leptospirosis 10.2 IL10 TNF
42 reactive arthritis 10.1 IL10 TNF
43 melioidosis 10.1 IL10 TNF
44 pyelonephritis 10.1 IL10 TNF
45 peptic ulcer disease 10.1 IL10 TNF
46 appendicitis 10.1 IL10 TNF
47 dengue hemorrhagic fever 10.1 IL10 TNF
48 human immunodeficiency virus infectious disease 10.1 IL10 TNF
49 adult respiratory distress syndrome 10.1 IL10 TNF
50 filariasis 10.1 IL10 TNF

Graphical network of the top 20 diseases related to Tropical Endomyocardial Fibrosis:



Diseases related to Tropical Endomyocardial Fibrosis

Symptoms & Phenotypes for Tropical Endomyocardial Fibrosis

MGI Mouse Phenotypes related to Tropical Endomyocardial Fibrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.43 IL10 IL4 TNF
2 liver/biliary system MP:0005370 9.33 IL10 IL4 TNF
3 no phenotypic analysis MP:0003012 9.13 IL10 IL4 TNF
4 respiratory system MP:0005388 8.8 IL10 IL4 TNF

Drugs & Therapeutics for Tropical Endomyocardial Fibrosis

Search Clinical Trials , NIH Clinical Center for Tropical Endomyocardial Fibrosis

Genetic Tests for Tropical Endomyocardial Fibrosis

Anatomical Context for Tropical Endomyocardial Fibrosis

MalaCards organs/tissues related to Tropical Endomyocardial Fibrosis:

41
Skeletal Muscle, Heart

Publications for Tropical Endomyocardial Fibrosis

Articles related to Tropical Endomyocardial Fibrosis:

(show all 21)
# Title Authors Year
1
Progressive mitral regurgitation in a patient with tropical endomyocardial fibrosis. ( 28582525 )
2017
2
Letter by Kothari Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881499 )
2016
3
Response by Grimaldi et al to Letter Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881500 )
2016
4
Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives. ( 27297343 )
2016
5
Non-tropical endomyocardial fibrosis: A rare cause of bi-apical filling. ( 26456913 )
2015
6
Plasma Cytokine Profile in Tropical Endomyocardial Fibrosis: Predominance of TNF-a, IL-4 and IL-10. ( 25303100 )
2014
7
Non-tropical endomyocardial fibrosis associated with sarcoidosis. ( 24168907 )
2013
8
Tropical endomyocardial fibrosis in India: a vanishing disease! ( 23287119 )
2012
9
Schistosomiasis and tropical endomyocardial fibrosis with pulmonary hypertension. ( 21592640 )
2011
10
Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and 'histamine dysmetabolism'. ( 18345505 )
2008
11
Ascites in tropical endomyocardial fibrosis. ( 18069682 )
2007
12
Tropical endomyocardial fibrosis (Davies' disease): case report demonstrating the role of magnetic resonance imaging. ( 15856635 )
2004
13
Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria. ( 9588233 )
1998
14
Pattern of cardiac calcification in tropical endomyocardial fibrosis. ( 2093711 )
1990
15
Is malaria involved in the pathogenesis of tropical endomyocardial fibrosis? ( 3072819 )
1988
16
Cardiac ultrastructure in tropical endomyocardial fibrosis. ( 3397162 )
1988
17
An autopsy study of tropical endomyocardial fibrosis in Kerala. ( 4093162 )
1985
18
Immunological phenomena in tropical endomyocardial fibrosis. ( 6724630 )
1984
19
Electron microscopic changes in tropical endomyocardial fibrosis. ( 6464108 )
1984
20
Skeletal muscle involvement in tropical endomyocardial fibrosis. ( 7077351 )
1982
21
Primary restrictive cardiomyopathy. Non-tropical endomyocardial fibrosis and hypereosinophilic heart disease. ( 869976 )
1977

Variations for Tropical Endomyocardial Fibrosis

Expression for Tropical Endomyocardial Fibrosis

Search GEO for disease gene expression data for Tropical Endomyocardial Fibrosis.

Pathways for Tropical Endomyocardial Fibrosis

Pathways related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.93 IL10 IL4 TNF
2
Show member pathways
12.87 IL10 IL4 TNF
3
Show member pathways
12.48 IL10 IL4 TNF
4
Show member pathways
12.23 IL10 IL4 TNF
5 12.17 IL10 IL4 TNF
6
Show member pathways
12.03 IL10 IL4 TNF
7
Show member pathways
11.99 IL10 IL4 TNF
8
Show member pathways
11.93 IL10 TNF
9 11.9 IL10 TNF
10
Show member pathways
11.88 IL10 TNF
11
Show member pathways
11.86 IL4 TNF
12 11.85 IL10 TNF
13
Show member pathways
11.82 IL10 IL4 TNF
14 11.7 IL4 TNF
15 11.6 IL4 TNF
16 11.59 IL10 TNF
17 11.56 IL10 IL4 TNF
18
Show member pathways
11.49 IL4 TNF
19 11.49 IL10 IL4 TNF
20 11.48 IL10 TNF
21 11.46 IL10 TNF
22 11.38 IL10 IL4
23 11.38 IL4 TNF
24 11.25 IL10 TNF
25 11.23 IL10 IL4 TNF
26 11.21 IL10 IL4
27 11.08 IL10 TNF
28 11.07 IL10 TNF
29 11.02 IL4 TNF
30 10.91 IL10 IL4
31 10.82 IL10 IL4 TNF
32 10.28 IL10 IL4 TNF

GO Terms for Tropical Endomyocardial Fibrosis

Biological processes related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.78 IL10 IL4 TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.74 IL10 IL4 TNF
3 immune response GO:0006955 9.73 IL10 IL4 TNF
4 regulation of signaling receptor activity GO:0010469 9.7 IL10 IL4 TNF
5 cytokine-mediated signaling pathway GO:0019221 9.63 IL10 IL4 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.61 IL10 TNF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.6 IL10 TNF
8 response to organic substance GO:0010033 9.59 IL10 TNF
9 B cell differentiation GO:0030183 9.58 IL10 IL4
10 response to glucocorticoid GO:0051384 9.58 IL10 TNF
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.55 IL10 TNF
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.54 IL10 IL4
13 negative regulation of mitotic cell cycle GO:0045930 9.51 IL10 TNF
14 positive regulation of cytokine secretion GO:0050715 9.49 IL10 TNF
15 negative regulation of interleukin-6 production GO:0032715 9.48 IL10 TNF
16 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 TNF
18 endothelial cell apoptotic process GO:0072577 9.37 IL10 TNF
19 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IL10 IL4
20 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 IL10 TNF
21 type 2 immune response GO:0042092 9.16 IL10 IL4
22 regulation of isotype switching GO:0045191 8.96 IL10 IL4
23 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.96 IL10 IL4
2 cytokine activity GO:0005125 8.8 IL10 IL4 TNF

Sources for Tropical Endomyocardial Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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