TEMF
MCID: TRP020
MIFTS: 37

Tropical Endomyocardial Fibrosis (TEMF)

Categories: Rare diseases

Aliases & Classifications for Tropical Endomyocardial Fibrosis

MalaCards integrated aliases for Tropical Endomyocardial Fibrosis:

Name: Tropical Endomyocardial Fibrosis 58
Davies Disease 58
Temf 58

Characteristics:

Orphanet epidemiological data:

58
tropical endomyocardial fibrosis
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood;

Classifications:



Summaries for Tropical Endomyocardial Fibrosis

MalaCards based summary : Tropical Endomyocardial Fibrosis, also known as davies disease, is related to endomyocardial fibrosis and hypereosinophilic syndrome. An important gene associated with Tropical Endomyocardial Fibrosis is IL10 (Interleukin 10), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. Affiliated tissues include heart, skin and lung, and related phenotypes are endocardial fibrosis and fatigue

Related Diseases for Tropical Endomyocardial Fibrosis

Diseases related to Tropical Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)
# Related Disease Score Top Affiliating Genes
1 endomyocardial fibrosis 30.6 TNF IL4 IL10
2 hypereosinophilic syndrome 30.2 IL4 IL10
3 alopecia 29.8 TNF IL4
4 schistosomiasis 29.5 TNF IL4 IL10
5 fibrosis of extraocular muscles, congenital, 1 10.5
6 restrictive cardiomyopathy 10.3
7 pulmonary hypertension 10.2
8 gastritis 10.1 TNF IL10
9 myelitis 10.1 TNF IL10
10 punctate inner choroidopathy 10.1 TNF IL10
11 multifocal choroiditis 10.1 TNF IL10
12 choroiditis 10.1 TNF IL10
13 spotted fever 10.1 TNF IL10
14 spotted fever rickettsiosis 10.1 TNF IL10
15 cervicitis 10.1 TNF IL10
16 palladium allergic contact dermatitis 10.1 TNF IL10
17 tertiary syphilis 10.1 TNF IL10
18 bacterial conjunctivitis 10.1 TNF IL10
19 post-transplant lymphoproliferative disease 10.1 TNF IL10
20 hypopyon 10.1 TNF IL10
21 chemical colitis 10.1 TNF IL10
22 enterocolitis 10.1 TNF IL10
23 transient hypogammaglobulinemia 10.1 TNF IL10
24 progressive myoclonus epilepsy 8 10.1 TNF IL10
25 vaginal discharge 10.1 TNF IL10
26 iritis 10.1 TNF IL10
27 chorioretinitis 10.1 TNF IL10
28 periapical periodontitis 10.1 TNF IL10
29 trichomoniasis 10.1 TNF IL10
30 clonorchiasis 10.1 TNF IL10
31 african tick-bite fever 10.1 TNF IL10
32 cardiomyopathy, familial hypertrophic, 20 10.1 TNF IL10
33 iridocyclitis 10.1 TNF IL10
34 epididymis disease 10.1 TNF IL10
35 idiopathic neutropenia 10.1 TNF IL10
36 orchitis 10.0 TNF IL10
37 urethritis 10.0 TNF IL10
38 tuberculoid leprosy 10.0 TNF IL10
39 funisitis 10.0 TNF IL10
40 macs syndrome 10.0 TNF IL10
41 central nervous system vasculitis 10.0 TNF IL10
42 cecal disease 10.0 TNF IL10
43 viral pneumonia 10.0 TNF IL10
44 sarcoidosis 1 10.0
45 schistosoma mansoni infection, susceptibility/ 10.0
46 constrictive pericarditis 10.0
47 mitral valve insufficiency 10.0
48 vascular disease 10.0
49 pericarditis 10.0
50 loeffler syndrome 10.0

Graphical network of the top 20 diseases related to Tropical Endomyocardial Fibrosis:



Diseases related to Tropical Endomyocardial Fibrosis

Symptoms & Phenotypes for Tropical Endomyocardial Fibrosis

Human phenotypes related to Tropical Endomyocardial Fibrosis:

58 31 (show all 48)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 endocardial fibrosis 58 31 obligate (100%) Obligate (100%) HP:0006685
2 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
3 restrictive cardiomyopathy 58 31 hallmark (90%) Very frequent (99-80%) HP:0001723
4 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
5 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
6 cardiomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0001640
7 ascites 58 31 frequent (33%) Frequent (79-30%) HP:0001541
8 atrioventricular block 58 31 frequent (33%) Frequent (79-30%) HP:0001678
9 cachexia 58 31 frequent (33%) Frequent (79-30%) HP:0004326
10 hypoalbuminemia 58 31 frequent (33%) Frequent (79-30%) HP:0003073
11 right bundle branch block 58 31 frequent (33%) Frequent (79-30%) HP:0011712
12 abnormal st segment 58 31 frequent (33%) Frequent (79-30%) HP:0012249
13 peripheral edema 58 31 frequent (33%) Frequent (79-30%) HP:0012398
14 malnutrition 58 31 frequent (33%) Frequent (79-30%) HP:0004395
15 left bundle branch block 58 31 frequent (33%) Frequent (79-30%) HP:0011713
16 orthopnea 58 31 frequent (33%) Frequent (79-30%) HP:0012764
17 left atrial enlargement 58 31 frequent (33%) Frequent (79-30%) HP:0031295
18 prolonged qrs complex 58 31 frequent (33%) Frequent (79-30%) HP:0006677
19 pulmonary venous hypertension 58 31 frequent (33%) Frequent (79-30%) HP:0030950
20 decreased qrs voltage 58 31 frequent (33%) Frequent (79-30%) HP:0025077
21 left ventricular diastolic dysfunction 58 31 frequent (33%) Frequent (79-30%) HP:0025168
22 systolic heart murmur 58 31 frequent (33%) Frequent (79-30%) HP:0031664
23 splenomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0001744
24 mitral regurgitation 58 31 occasional (7.5%) Occasional (29-5%) HP:0001653
25 proptosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000520
26 eosinophilia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001880
27 atrial fibrillation 58 31 occasional (7.5%) Occasional (29-5%) HP:0005110
28 tricuspid regurgitation 58 31 occasional (7.5%) Occasional (29-5%) HP:0005180
29 reduced ejection fraction 58 31 occasional (7.5%) Occasional (29-5%) HP:0012664
30 pedal edema 58 31 occasional (7.5%) Occasional (29-5%) HP:0010741
31 abnormal t-wave 58 31 occasional (7.5%) Occasional (29-5%) HP:0005135
32 thromboembolism 58 31 occasional (7.5%) Occasional (29-5%) HP:0001907
33 autoimmune antibody positivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0030057
34 elevated jugular venous pressure 58 31 occasional (7.5%) Occasional (29-5%) HP:0030848
35 atrial flutter 58 31 occasional (7.5%) Occasional (29-5%) HP:0004749
36 cardiogenic shock 58 31 occasional (7.5%) Occasional (29-5%) HP:0030149
37 supraventricular tachycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0004755
38 right ventricular cardiomyopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0011663
39 myocardial calcification 58 31 occasional (7.5%) Occasional (29-5%) HP:0006690
40 increased circulating interleukin 6 31 occasional (7.5%) HP:0030783
41 coronary artery stenosis 58 31 very rare (1%) Very rare (<4-1%) HP:0005145
42 p pulmonale 58 31 very rare (1%) Very rare (<4-1%) HP:0031601
43 dyspnea 58 Very frequent (99-80%)
44 arrhythmia 58 Frequent (79-30%)
45 abnormal ekg 58 Very frequent (99-80%)
46 abnormal p wave 58 Occasional (29-5%)
47 increased serum interleukin-6 58 Occasional (29-5%)
48 abnormal atrioventricular valve physiology 58 Occasional (29-5%)

Drugs & Therapeutics for Tropical Endomyocardial Fibrosis

Search Clinical Trials , NIH Clinical Center for Tropical Endomyocardial Fibrosis

Genetic Tests for Tropical Endomyocardial Fibrosis

Anatomical Context for Tropical Endomyocardial Fibrosis

MalaCards organs/tissues related to Tropical Endomyocardial Fibrosis:

40
Heart, Skin, Lung, Skeletal Muscle, Eye, Bone, Lymph Node

Publications for Tropical Endomyocardial Fibrosis

Articles related to Tropical Endomyocardial Fibrosis:

(show all 45)
# Title Authors PMID Year
1
[Cardiac manifestations of tropical diseases]. 61
30656388 2019
2
[Tropical endomyocardial fibrosis: Perspectives]. 61
29602442 2018
3
Progressive mitral regurgitation in a patient with tropical endomyocardial fibrosis. 61
28582525 2017
4
Cardiac manifestations of parasitic diseases. 61
28285268 2017
5
Tropical diseases of the myocardium: a review. 61
28435310 2017
6
Letter by Kothari Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". 61
27881499 2016
7
Response by Grimaldi et al to Letter Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". 61
27881500 2016
8
Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives. 61
27297343 2016
9
Refinement and growth enhancement of Al2Cu phase during magnetic field assisting directional solidification of hypereutectic Al-Cu alloy. 61
27091383 2016
10
Non-tropical endomyocardial fibrosis: A rare cause of bi-apical filling. 61
26456913 2016
11
Establishment and characterization of fin cell lines from diploid, triploid, and tetraploid oriental weatherfish (Misgurnus anguillicaudatus). 61
25721100 2015
12
Tapioca Cardiomyopathy: Curse of Cassava Endomyocardial Fibrosis. 61
28197237 2015
13
Non-tropical endomyocardial fibrosis associated with sarcoidosis. 61
24168907 2014
14
Plasma cytokine profile in tropical endomyocardial fibrosis: predominance of TNF-a, IL-4 and IL-10. 61
25303100 2014
15
[Tropical endomyocardial fibrosis in Spain]. 61
23092821 2013
16
Electrostatic spin crossover and concomitant electrically operated spin switch action in a ti-based endohedral metallofullerene polymer. 61
23368493 2012
17
Tropical endomyocardial fibrosis in India: a vanishing disease! 61
23287119 2012
18
Schistosomiasis and tropical endomyocardial fibrosis with pulmonary hypertension. 61
21592640 2011
19
Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and 'histamine dysmetabolism'. 61
18345505 2008
20
Ascites in tropical endomyocardial fibrosis. 61
18069682 2007
21
Prospective, randomized, single-blind, sham treatment-controlled study of the safety and efficacy of an electromagnetic field device for the treatment of chronic low back pain: a pilot study. 61
17714104 2007
22
Effects of different extremely low-frequency electromagnetic fields on osteoblasts. 61
17886004 2007
23
Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis. 61
16045802 2005
24
Low frequency therapeutic EMF differently influences experimental muscle pain in female and male subjects. 61
15832331 2005
25
Computational method for temporal pattern discovery in biomedical genomic databases. 61
16447993 2005
26
Tropical endomyocardial fibrosis (Davies' disease): case report demonstrating the role of magnetic resonance imaging. 61
15856635 2004
27
Therapeutic electromagnetic field effects on angiogenesis and tumor growth. 61
11911264 2001
28
[Tropical endomyocardial fibrosis or Davies disease. A case report]. 61
11181314 2001
29
Alterations in collagen metabolism and increased fibroproliferation in the heart in cerium-treated rats: implications for the pathogenesis of endomyocardial fibrosis. 61
9764572 1998
30
Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria. 61
9588233 1998
31
Levels of cerium in the tissues of rats fed a magnesium-restricted and cerium-adulterated diet. 61
8720088 1996
32
Cerium stimulates protein biosynthesis in rat heart in vivo. 61
8962795 1995
33
Myocardial and endocardial involvement in tuberculous constrictive pericarditis: difficulty in biopsy distinction from endomyocardial fibrosis as a cause of restrictive heart disease. 61
2394527 1990
34
Endomyocardial fibrosis in dermatomyositis. 61
2365526 1990
35
Pattern of cardiac calcification in tropical endomyocardial fibrosis. 61
2093711 1990
36
Cardiac ultrastructure in tropical endomyocardial fibrosis. 61
3397162 1988
37
Is malaria involved in the pathogenesis of tropical endomyocardial fibrosis? 61
3072819 1988
38
A geochemical basis for endomyocardial fibrosis. 61
3791358 1986
39
An autopsy study of tropical endomyocardial fibrosis in Kerala. 61
4093162 1985
40
Immunological phenomena in tropical endomyocardial fibrosis. 61
6724630 1984
41
Electron microscopic changes in tropical endomyocardial fibrosis. 61
6464108 1984
42
Skeletal muscle involvement in tropical endomyocardial fibrosis. 61
7077351 1982
43
Primary restrictive cardiomyopathy. Non-tropical endomyocardial fibrosis and hypereosinophilic heart disease. 61
869976 1977
44
Endomyocardial fibrosis associated with daunorubicin therapy. 61
1067858 1976
45
[African or tropical endomyocardial fibrosis. Report of the 1st case seen in Mexico]. 61
5126058 1971

Variations for Tropical Endomyocardial Fibrosis

Expression for Tropical Endomyocardial Fibrosis

Search GEO for disease gene expression data for Tropical Endomyocardial Fibrosis.

Pathways for Tropical Endomyocardial Fibrosis

Pathways related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 TNF IL4 IL10
2
Show member pathways
12.49 TNF IL4 IL10
3
Show member pathways
12.26 TNF IL4 IL10
4
Show member pathways
12.21 TNF IL4 IL10
5
Show member pathways
12.19 TNF IL4 IL10
6 12.12 TNF IL4 IL10
7
Show member pathways
11.86 TNF IL4 IL10
8
Show member pathways
11.84 TNF IL4 IL10
9 11.79 TNF IL10
10 11.73 TNF IL4
11 11.65 TNF IL10
12 11.63 TNF IL4
13 11.61 TNF IL4 IL10
14 11.55 TNF IL4 IL10
15
Show member pathways
11.51 TNF IL10
16 11.51 TNF IL10
17
Show member pathways
11.5 TNF IL4
18 11.49 TNF IL10
19 11.41 TNF IL4
20 11.4 IL4 IL10
21 11.34 TNF IL4 IL10
22 11.3 TNF IL10
23 11.25 IL4 IL10
24 11.15 TNF IL4 IL10
25 11.14 TNF IL10
26
Show member pathways
11.11 TNF IL10
27 11.09 TNF IL10
28 11.04 TNF IL4
29 10.93 IL4 IL10
30 10.82 TNF IL4 IL10
31 10.67 TNF IL4 IL10
32 10.26 TNF IL4 IL10

GO Terms for Tropical Endomyocardial Fibrosis

Biological processes related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.81 TNF IL4 IL10
2 positive regulation of transcription, DNA-templated GO:0045893 9.76 TNF IL4 IL10
3 immune response GO:0006955 9.71 TNF IL4 IL10
4 negative regulation of inflammatory response GO:0050728 9.63 IL4 IL10
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.62 TNF IL10
6 response to organic substance GO:0010033 9.62 TNF IL10
7 B cell differentiation GO:0030183 9.61 IL4 IL10
8 negative regulation of tumor necrosis factor production GO:0032720 9.61 IL4 IL10
9 cytokine-mediated signaling pathway GO:0019221 9.61 TNF IL4 IL10
10 negative regulation of interleukin-6 production GO:0032715 9.6 TNF IL10
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.59 TNF IL4
12 response to glucocorticoid GO:0051384 9.58 TNF IL10
13 positive regulation of cytokine production GO:0001819 9.57 TNF IL10
14 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.56 TNF IL10
15 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.55 TNF IL10
16 negative regulation of endothelial cell apoptotic process GO:2000352 9.52 IL4 IL10
17 negative regulation of mitotic cell cycle GO:0045930 9.51 TNF IL10
18 positive regulation of JAK-STAT cascade GO:0046427 9.49 TNF IL10
19 microglial cell activation GO:0001774 9.48 TNF IL4
20 regulation of synapse organization GO:0050807 9.46 TNF IL10
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 TNF IL10
22 positive regulation of MHC class II biosynthetic process GO:0045348 9.37 IL4 IL10
23 endothelial cell apoptotic process GO:0072577 9.32 TNF IL10
24 positive regulation of mononuclear cell migration GO:0071677 9.26 TNF IL4
25 negative regulation of cytokine production involved in immune response GO:0002719 9.16 TNF IL10
26 type 2 immune response GO:0042092 8.96 IL4 IL10
27 regulation of isotype switching GO:0045191 8.62 IL4 IL10

Molecular functions related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 TNF IL4 IL10

Sources for Tropical Endomyocardial Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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