TEMF
MCID: TRP020
MIFTS: 31

Tropical Endomyocardial Fibrosis (TEMF)

Categories: Rare diseases

Aliases & Classifications for Tropical Endomyocardial Fibrosis

MalaCards integrated aliases for Tropical Endomyocardial Fibrosis:

Name: Tropical Endomyocardial Fibrosis 60
Davies Disease 60
Temf 60

Characteristics:

Orphanet epidemiological data:

60
tropical endomyocardial fibrosis
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood;

Classifications:



External Ids:

ICD10 via Orphanet 35 I42.3
Orphanet 60 ORPHA75565

Summaries for Tropical Endomyocardial Fibrosis

MalaCards based summary : Tropical Endomyocardial Fibrosis, also known as davies disease, is related to endomyocardial fibrosis and schistosomiasis. An important gene associated with Tropical Endomyocardial Fibrosis is IL4 (Interleukin 4), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. Affiliated tissues include skeletal muscle, and related phenotypes are craniofacial and liver/biliary system

Related Diseases for Tropical Endomyocardial Fibrosis

Diseases related to Tropical Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 endomyocardial fibrosis 30.5 IL10 IL4 TNF
2 schistosomiasis 29.5 IL10 IL4 TNF
3 malaria 29.4 IL10 IL4 TNF
4 systemic lupus erythematosus 28.9 IL10 IL4 TNF
5 keratoconjunctivitis 10.1 IL4 TNF
6 scleritis 10.1 IL4 TNF
7 opisthorchiasis 10.1 IL4 TNF
8 lichen disease 10.1 IL4 TNF
9 conjunctival disease 10.1 IL4 TNF
10 rasmussen encephalitis 10.1 IL4 TNF
11 neuritis 10.0 IL4 TNF
12 tonsillitis 10.0 IL4 TNF
13 pulmonary hypertension 10.0
14 heart disease 10.0
15 mitral valve insufficiency 10.0
16 vascular disease 10.0
17 restrictive cardiomyopathy 10.0
18 gingivitis 10.0 IL4 TNF
19 behcet syndrome 10.0 IL10 TNF
20 sudden infant death syndrome 10.0 IL10 TNF
21 crohn's disease 10.0 IL10 TNF
22 hemophagocytic lymphohistiocytosis 10.0 IL10 TNF
23 ulcerative colitis 10.0 IL10 TNF
24 nervous system disease 10.0 IL10 TNF
25 pneumonia 10.0 IL10 TNF
26 bacterial infectious disease 10.0 IL10 TNF
27 leukocyte disease 10.0 IL4 TNF
28 punctate inner choroidopathy 10.0 IL10 TNF
29 multifocal choroiditis 10.0 IL10 TNF
30 choroiditis 10.0 IL10 TNF
31 transient hypogammaglobulinemia 10.0 IL10 TNF
32 cow milk allergy 10.0 IL10 TNF
33 trichuriasis 10.0 IL10 TNF
34 idiopathic achalasia 10.0 IL10 TNF
35 mucocutaneous leishmaniasis 10.0 IL10 TNF
36 chronic graft versus host disease 10.0 IL10 TNF
37 clonorchiasis 10.0 IL10 TNF
38 trachoma 10.0 IL10 TNF
39 meningitis 10.0 IL10 TNF
40 autoimmune disease of eyes, ear, nose and throat 10.0 IL10 TNF
41 intermediate uveitis 10.0 IL10 TNF
42 transverse myelitis 10.0 IL10 TNF
43 post-transplant lymphoproliferative disease 10.0 IL10 TNF
44 multidrug-resistant tuberculosis 10.0 IL10 TNF
45 hemorrhagic fever 10.0 IL10 TNF
46 spotted fever 10.0 IL10 TNF
47 hematopoietic stem cell transplantation 10.0 IL10 TNF
48 aseptic meningitis 10.0 IL10 TNF
49 lichen planus 10.0 IL4 TNF
50 scrub typhus 10.0 IL10 TNF

Graphical network of the top 20 diseases related to Tropical Endomyocardial Fibrosis:



Diseases related to Tropical Endomyocardial Fibrosis

Symptoms & Phenotypes for Tropical Endomyocardial Fibrosis

MGI Mouse Phenotypes related to Tropical Endomyocardial Fibrosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.33 IL10 IL4 TNF
2 liver/biliary system MP:0005370 9.13 IL10 IL4 TNF
3 no phenotypic analysis MP:0003012 8.8 IL10 IL4 TNF

Drugs & Therapeutics for Tropical Endomyocardial Fibrosis

Search Clinical Trials , NIH Clinical Center for Tropical Endomyocardial Fibrosis

Genetic Tests for Tropical Endomyocardial Fibrosis

Anatomical Context for Tropical Endomyocardial Fibrosis

MalaCards organs/tissues related to Tropical Endomyocardial Fibrosis:

42
Skeletal Muscle

Publications for Tropical Endomyocardial Fibrosis

Articles related to Tropical Endomyocardial Fibrosis:

(show all 23)
# Title Authors Year
1
Endomyocardial fibrosis. Davies disease. Multimodality imaging. ( 30797540 )
2019
2
Progressive mitral regurgitation in a patient with tropical endomyocardial fibrosis. ( 28582525 )
2017
3
Letter by Kothari Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881499 )
2016
4
Response by Grimaldi et al to Letter Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881500 )
2016
5
Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives. ( 27297343 )
2016
6
Non-tropical endomyocardial fibrosis: A rare cause of bi-apical filling. ( 26456913 )
2015
7
Plasma Cytokine Profile in Tropical Endomyocardial Fibrosis: Predominance of TNF-a, IL-4 and IL-10. ( 25303100 )
2014
8
Non-tropical endomyocardial fibrosis associated with sarcoidosis. ( 24168907 )
2013
9
Tropical endomyocardial fibrosis in India: a vanishing disease! ( 23287119 )
2012
10
Schistosomiasis and tropical endomyocardial fibrosis with pulmonary hypertension. ( 21592640 )
2011
11
Insights of prognostication of Davies disease: what could we learn from serial magnetic resonance imaging studies? ( 19144428 )
2010
12
Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and 'histamine dysmetabolism'. ( 18345505 )
2008
13
Ascites in tropical endomyocardial fibrosis. ( 18069682 )
2007
14
Tropical endomyocardial fibrosis (Davies' disease): case report demonstrating the role of magnetic resonance imaging. ( 15856635 )
2004
15
Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria. ( 9588233 )
1998
16
Pattern of cardiac calcification in tropical endomyocardial fibrosis. ( 2093711 )
1990
17
Is malaria involved in the pathogenesis of tropical endomyocardial fibrosis? ( 3072819 )
1988
18
Cardiac ultrastructure in tropical endomyocardial fibrosis. ( 3397162 )
1988
19
An autopsy study of tropical endomyocardial fibrosis in Kerala. ( 4093162 )
1985
20
Immunological phenomena in tropical endomyocardial fibrosis. ( 6724630 )
1984
21
Electron microscopic changes in tropical endomyocardial fibrosis. ( 6464108 )
1984
22
Skeletal muscle involvement in tropical endomyocardial fibrosis. ( 7077351 )
1982
23
Primary restrictive cardiomyopathy. Non-tropical endomyocardial fibrosis and hypereosinophilic heart disease. ( 869976 )
1977

Variations for Tropical Endomyocardial Fibrosis

Expression for Tropical Endomyocardial Fibrosis

Search GEO for disease gene expression data for Tropical Endomyocardial Fibrosis.

Pathways for Tropical Endomyocardial Fibrosis

Pathways related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 IL10 IL4 TNF
2
Show member pathways
12.9 IL10 IL4 TNF
3
Show member pathways
12.51 IL10 IL4 TNF
4
Show member pathways
12.27 IL10 IL4 TNF
5
Show member pathways
12.22 IL10 IL4 TNF
6 12.17 IL10 IL4 TNF
7
Show member pathways
12.04 IL10 IL4 TNF
8 11.93 IL10 TNF
9
Show member pathways
11.91 IL10 TNF
10
Show member pathways
11.88 IL4 TNF
11
Show member pathways
11.88 IL10 IL4 TNF
12
Show member pathways
11.88 IL10 IL4 TNF
13 11.87 IL10 TNF
14
Show member pathways
11.76 IL10 TNF
15
Show member pathways
11.75 IL4 TNF
16 11.72 IL4 TNF
17 11.62 IL4 TNF
18 11.62 IL10 TNF
19 11.61 IL10 IL4 TNF
20 11.55 IL10 IL4 TNF
21
Show member pathways
11.51 IL4 TNF
22 11.5 IL10 TNF
23 11.49 IL10 TNF
24 11.41 IL10 IL4
25 11.4 IL4 TNF
26 11.34 IL10 IL4 TNF
27 11.28 IL10 TNF
28 11.24 IL10 IL4
29 11.18 IL10 IL4 TNF
30 11.14 IL10 TNF
31 11.1 IL10 TNF
32 11.05 IL4 TNF
33 10.94 IL10 IL4
34 10.82 IL10 IL4 TNF
35 10.81 IL10 IL4 TNF
36 10.66 IL10 IL4 TNF
37 10.26 IL10 IL4 TNF

GO Terms for Tropical Endomyocardial Fibrosis

Biological processes related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.79 IL10 IL4 TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.75 IL10 IL4 TNF
3 immune response GO:0006955 9.73 IL10 IL4 TNF
4 regulation of signaling receptor activity GO:0010469 9.7 IL10 IL4 TNF
5 cytokine-mediated signaling pathway GO:0019221 9.63 IL10 IL4 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.62 IL10 TNF
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.61 IL10 TNF
8 response to organic substance GO:0010033 9.6 IL10 TNF
9 B cell differentiation GO:0030183 9.59 IL10 IL4
10 response to glucocorticoid GO:0051384 9.58 IL10 TNF
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.57 IL10 TNF
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.55 IL10 IL4
13 negative regulation of mitotic cell cycle GO:0045930 9.54 IL10 TNF
14 negative regulation of interleukin-6 production GO:0032715 9.51 IL10 TNF
15 positive regulation of cytokine secretion GO:0050715 9.49 IL10 TNF
16 regulation of synapse organization GO:0050807 9.48 IL10 TNF
17 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 TNF
19 endothelial cell apoptotic process GO:0072577 9.37 IL10 TNF
20 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IL10 IL4
21 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 IL10 TNF
22 regulation of isotype switching GO:0045191 9.16 IL10 IL4
23 type 2 immune response GO:0042092 8.96 IL10 IL4
24 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.96 IL10 IL4
2 cytokine activity GO:0005125 8.8 IL10 IL4 TNF

Sources for Tropical Endomyocardial Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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