MCID: TRP020
MIFTS: 33

Tropical Endomyocardial Fibrosis

Categories: Rare diseases

Aliases & Classifications for Tropical Endomyocardial Fibrosis

MalaCards integrated aliases for Tropical Endomyocardial Fibrosis:

Name: Tropical Endomyocardial Fibrosis 60
Davies Disease 60
Temf 60

Characteristics:

Orphanet epidemiological data:

60
tropical endomyocardial fibrosis
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood;

Classifications:



External Ids:

ICD10 via Orphanet 35 I42.3
Orphanet 60 ORPHA75565

Summaries for Tropical Endomyocardial Fibrosis

MalaCards based summary : Tropical Endomyocardial Fibrosis, also known as davies disease, is related to endomyocardial fibrosis and schistosomiasis. An important gene associated with Tropical Endomyocardial Fibrosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. Affiliated tissues include skeletal muscle, skin and lymph node, and related phenotypes are craniofacial and liver/biliary system

Related Diseases for Tropical Endomyocardial Fibrosis

Diseases related to Tropical Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 197, show less)
# Related Disease Score Top Affiliating Genes
1 endomyocardial fibrosis 30.5 IL10 IL4 TNF
2 schistosomiasis 29.5 IL10 IL4 TNF
3 malaria 29.4 IL10 IL4 TNF
4 systemic lupus erythematosus 28.9 IL10 IL4 TNF
5 behcet syndrome 10.1 IL10 TNF
6 sudden infant death syndrome 10.1 IL10 TNF
7 crohn's disease 10.1 IL10 TNF
8 hemophagocytic lymphohistiocytosis 10.1 IL10 TNF
9 ulcerative colitis 10.1 IL10 TNF
10 nervous system disease 10.1 IL10 TNF
11 pneumonia 10.1 IL10 TNF
12 bacterial infectious disease 10.1 IL10 TNF
13 punctate inner choroidopathy 10.1 IL10 TNF
14 multifocal choroiditis 10.1 IL10 TNF
15 choroiditis 10.1 IL10 TNF
16 transient hypogammaglobulinemia 10.1 IL10 TNF
17 cow milk allergy 10.1 IL10 TNF
18 trichuriasis 10.1 IL10 TNF
19 idiopathic achalasia 10.1 IL10 TNF
20 mucocutaneous leishmaniasis 10.1 IL10 TNF
21 chronic graft versus host disease 10.1 IL10 TNF
22 clonorchiasis 10.1 IL10 TNF
23 trachoma 10.1 IL10 TNF
24 meningitis 10.1 IL10 TNF
25 autoimmune disease of eyes, ear, nose and throat 10.1 IL10 TNF
26 intermediate uveitis 10.1 IL10 TNF
27 transverse myelitis 10.1 IL10 TNF
28 post-transplant lymphoproliferative disease 10.1 IL10 TNF
29 multidrug-resistant tuberculosis 10.1 IL10 TNF
30 spotted fever 10.1 IL10 TNF
31 hematopoietic stem cell transplantation 10.1 IL10 TNF
32 aseptic meningitis 10.1 IL10 TNF
33 scrub typhus 10.1 IL10 TNF
34 panuveitis 10.1 IL10 TNF
35 plasmodium vivax malaria 10.1 IL10 TNF
36 bacterial sepsis 10.1 IL10 TNF
37 lacrimal apparatus disease 10.1 IL10 TNF
38 commensal bacterial infectious disease 10.1 IL10 TNF
39 churg-strauss syndrome 10.1 IL10 TNF
40 epstein-barr virus-associated gastric carcinoma 10.1 IL10 TNF
41 leprosy 3 10.1 IL10 TNF
42 complex regional pain syndrome 10.1 IL10 TNF
43 viral encephalitis 10.1 IL10 TNF
44 rheumatic fever 10.1 IL10 TNF
45 idiopathic neutropenia 10.1 IL10 TNF
46 lepromatous leprosy 10.1 IL10 TNF
47 prostatitis 10.1 IL10 TNF
48 lymph node disease 10.1 IL10 TNF
49 testicular disease 10.1 IL10 TNF
50 mixed connective tissue disease 10.1 IL10 TNF
51 connective tissue disease 10.1 IL10 TNF
52 echinococcosis 10.1 IL10 TNF
53 uveal disease 10.1 IL10 TNF
54 melioidosis 10.1 IL10 TNF
55 primary progressive multiple sclerosis 10.1 IL10 TNF
56 pyelonephritis 10.0 IL10 TNF
57 leptospirosis 10.0 IL10 TNF
58 reactive arthritis 10.0 IL10 TNF
59 peptic ulcer disease 10.0 IL10 TNF
60 hepatitis a 10.0 IL10 TNF
61 appendicitis 10.0 IL10 TNF
62 human immunodeficiency virus infectious disease 10.0 IL10 TNF
63 bronchiolitis obliterans 10.0 IL10 TNF
64 sarcoidosis 1 10.0
65 pulmonary hypertension 10.0
66 heart disease 10.0
67 mitral valve insufficiency 10.0
68 vascular disease 10.0
69 restrictive cardiomyopathy 10.0
70 hypereosinophilic syndrome 10.0
71 adult respiratory distress syndrome 10.0 IL10 TNF
72 dengue hemorrhagic fever 10.0 IL10 TNF
73 filariasis 10.0 IL10 TNF
74 pulmonary edema 10.0 IL10 TNF
75 bacterial meningitis 10.0 IL10 TNF
76 irritable bowel syndrome 10.0 IL10 TNF
77 endocarditis 10.0 IL10 TNF
78 chronic mucocutaneous candidiasis 10.0 IL10 TNF
79 keratoconjunctivitis 10.0 IL4 TNF
80 alcoholic hepatitis 10.0 IL10 TNF
81 lymphadenitis 10.0 IL10 TNF
82 osteomyelitis 10.0 IL10 TNF
83 chronic fatigue syndrome 10.0 IL10 TNF
84 graft-versus-host disease 10.0 IL10 TNF
85 scleritis 10.0 IL4 TNF
86 opisthorchiasis 10.0 IL4 TNF
87 plasmodium falciparum malaria 10.0 IL10 TNF
88 peritonitis 10.0 IL10 TNF
89 lichen disease 10.0 IL4 TNF
90 conjunctival disease 10.0 IL4 TNF
91 acquired immunodeficiency syndrome 10.0 IL10 TNF
92 rasmussen encephalitis 10.0 IL4 TNF
93 diabetes mellitus, insulin-dependent 10.0 IL10 IL4
94 allergic rhinitis 9.9 IL10 IL4
95 chagas disease 9.9 IL10 TNF
96 intestinal disease 9.9 IL10 TNF
97 hyperlucent lung 9.9 IL10 IL4
98 nickel allergic contact dermatitis 9.9 IL10 IL4
99 retinitis pigmentosa 22 9.9 IL10 IL4
100 baylisascariasis 9.9 IL10 IL4
101 neuritis 9.9 IL4 TNF
102 milk allergy 9.9 IL10 IL4
103 apple allergy 9.9 IL10 IL4
104 beta-lactam allergy 9.9 IL10 IL4
105 kawasaki disease 9.9 IL10 TNF
106 gaucher disease, type ii 9.9 IL10 IL4
107 tonsillitis 9.9 IL4 TNF
108 eosinophilic meningitis 9.9 IL10 IL4
109 filarial elephantiasis 9.9 IL10 IL4
110 buruli ulcer 9.9 IL10 IL4
111 bardet-biedl syndrome 15 9.9 IL10 IL4
112 mouth disease 9.9 IL10 TNF
113 genital herpes 9.9 IL10 IL4
114 gingivitis 9.9 IL4 TNF
115 paranasal sinus disease 9.9 IL10 IL4
116 transient hypogammaglobulinemia of infancy 9.9 IL10 IL4
117 nasal cavity disease 9.9 IL10 IL4
118 leukocyte disease 9.9 IL4 TNF
119 pertussis 9.9 IL10 TNF
120 respiratory allergy 9.9 IL10 IL4
121 ige responsiveness, atopic 9.9 IL10 IL4
122 lupus erythematosus 9.9
123 mitral valve disease 9.9 IL10 IL4
124 lichen planus 9.8 IL4 TNF
125 food allergy 9.8 IL10 IL4
126 immune deficiency disease 9.8 IL10 IL4
127 demyelinating disease 9.8 IL10 TNF
128 rheumatic disease 9.8 IL10 TNF
129 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8 IL10 IL4
130 tetanus 9.8 IL10 IL4
131 allergic asthma 9.7 IL10 IL4
132 tungiasis 9.6 IL10 IL4 TNF
133 autoimmune gastritis 9.6 IL10 IL4 TNF
134 orofacial granulomatosis 9.6 IL10 IL4 TNF
135 primary systemic mycosis 9.6 IL10 IL4 TNF
136 mycoplasma pneumoniae pneumonia 9.6 IL10 IL4 TNF
137 poliomyelitis 9.6 IL10 IL4 TNF
138 eales disease 9.6 IL10 IL4 TNF
139 coccidiosis 9.6 IL10 IL4 TNF
140 q fever 9.6 IL10 IL4 TNF
141 aphthous stomatitis 9.6 IL10 IL4 TNF
142 acute graft versus host disease 9.6 IL10 IL4 TNF
143 keratoconjunctivitis sicca 9.6 IL10 IL4 TNF
144 extrinsic cardiomyopathy 9.6 IL10 IL4 TNF
145 spondyloarthropathy 9.6 IL10 IL4 TNF
146 autoimmune uveitis 9.6 IL10 IL4 TNF
147 uveitis 9.6 IL10 IL4 TNF
148 paracoccidioidomycosis 9.6 IL10 IL4 TNF
149 opportunistic mycosis 9.6 IL10 IL4 TNF
150 rheumatic heart disease 9.6 IL10 IL4 TNF
151 nose disease 9.6 IL10 IL4 TNF
152 parasitic helminthiasis infectious disease 9.6 IL10 IL4 TNF
153 brucellosis 9.6 IL10 IL4 TNF
154 parasitic protozoa infectious disease 9.6 IL10 IL4 TNF
155 autoimmune disease of musculoskeletal system 9.6 IL10 IL4 TNF
156 autoimmune disease 9.6 IL10 IL4 TNF
157 autoimmune disease of central nervous system 9.6 IL10 IL4 TNF
158 allergic contact dermatitis 9.6 IL10 IL4 TNF
159 contact dermatitis 9.6 IL10 IL4 TNF
160 aggressive periodontitis 9.6 IL10 IL4 TNF
161 periodontitis 9.6 IL10 IL4 TNF
162 upper respiratory tract disease 9.6 IL10 IL4 TNF
163 primary bacterial infectious disease 9.6 IL10 IL4 TNF
164 cutaneous leishmaniasis 9.6 IL10 IL4 TNF
165 leishmaniasis 9.6 IL10 IL4 TNF
166 gastroenteritis 9.6 IL10 IL4 TNF
167 rubella 9.6 IL10 IL4 TNF
168 bronchial disease 9.6 IL10 IL4 TNF
169 visceral leishmaniasis 9.6 IL10 IL4 TNF
170 aspergillosis 9.6 IL10 IL4 TNF
171 bone inflammation disease 9.6 IL10 IL4 TNF
172 chlamydia 9.6 IL10 IL4 TNF
173 toxic shock syndrome 9.6 IL10 IL4 TNF
174 toxoplasmosis 9.6 IL10 IL4 TNF
175 bronchiolitis 9.6 IL10 IL4 TNF
176 relapsing-remitting multiple sclerosis 9.6 IL10 IL4 TNF
177 multiple sclerosis 9.6 IL10 IL4 TNF
178 otitis media 9.6 IL10 IL4 TNF
179 trypanosomiasis 9.6 IL10 IL4 TNF
180 proteasome-associated autoinflammatory syndrome 1 9.6 IL10 IL4 TNF
181 pulmonary tuberculosis 9.6 IL10 IL4 TNF
182 myasthenia gravis 9.6 IL10 IL4 TNF
183 omenn syndrome 9.6 IL10 IL4 TNF
184 respiratory system disease 9.6 IL10 IL4 TNF
185 interstitial lung disease 9.6 IL10 IL4 TNF
186 immune system disease 9.6 IL10 IL4 TNF
187 mycobacterium tuberculosis 1 9.6 IL10 IL4 TNF
188 viral infectious disease 9.6 IL10 IL4 TNF
189 dermatitis, atopic 9.6 IL10 IL4 TNF
190 colitis 9.6 IL10 IL4 TNF
191 common variable immunodeficiency 9.6 IL10 IL4 TNF
192 inflammatory bowel disease 9.6 IL10 IL4 TNF
193 skin disease 9.6 IL10 IL4 TNF
194 gastrointestinal system disease 9.6 IL10 TNF
195 rheumatoid arthritis 9.6 IL10 IL4 TNF
196 allergic hypersensitivity disease 9.6 IL10 IL4
197 asthma 9.5 IL10 IL4 TNF

Graphical network of the top 20 diseases related to Tropical Endomyocardial Fibrosis:



Diseases related to Tropical Endomyocardial Fibrosis

Symptoms & Phenotypes for Tropical Endomyocardial Fibrosis

MGI Mouse Phenotypes related to Tropical Endomyocardial Fibrosis:

47 (showing 3, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.33 IL10 IL4 TNF
2 liver/biliary system MP:0005370 9.13 IL10 IL4 TNF
3 no phenotypic analysis MP:0003012 8.8 IL10 IL4 TNF

Drugs & Therapeutics for Tropical Endomyocardial Fibrosis

Search Clinical Trials , NIH Clinical Center for Tropical Endomyocardial Fibrosis

Genetic Tests for Tropical Endomyocardial Fibrosis

Anatomical Context for Tropical Endomyocardial Fibrosis

MalaCards organs/tissues related to Tropical Endomyocardial Fibrosis:

42
Skeletal Muscle, Skin, Lymph Node, Eye, Tonsil

Publications for Tropical Endomyocardial Fibrosis

Articles related to Tropical Endomyocardial Fibrosis:

(showing 24, show less)
# Title Authors Year
1
Endomyocardial fibrosis. Davies disease. Multimodality imaging. ( 30797540 )
2019
2
Progressive mitral regurgitation in a patient with tropical endomyocardial fibrosis. ( 28582525 )
2017
3
Non-tropical endomyocardial fibrosis: A rare cause of bi-apical filling. ( 26456913 )
2016
4
Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives. ( 27297343 )
2016
5
Letter by Kothari Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881499 )
2016
6
Response by Grimaldi et al to Letter Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881500 )
2016
7
Non-tropical endomyocardial fibrosis associated with sarcoidosis. ( 24168907 )
2014
8
Plasma cytokine profile in tropical endomyocardial fibrosis: predominance of TNF-a, IL-4 and IL-10. ( 25303100 )
2014
9
Tropical endomyocardial fibrosis in India: a vanishing disease! ( 23287119 )
2012
10
Schistosomiasis and tropical endomyocardial fibrosis with pulmonary hypertension. ( 21592640 )
2011
11
Insights of prognostication of Davies disease: what could we learn from serial magnetic resonance imaging studies? ( 19144428 )
2010
12
Part III. keyword-based, boolean-logic driven data-mining discloses correlations between additional idiopathic conditions, occlusive vascular diseases such as tropical endomyocardial fibrosis with unexplained eosinophilia, and 'histamine dysmetabolism'. ( 18345505 )
2008
13
Ascites in tropical endomyocardial fibrosis. ( 18069682 )
2007
14
Tropical endomyocardial fibrosis (Davies' disease): case report demonstrating the role of magnetic resonance imaging. ( 15856635 )
2004
15
Endomyocardial fibrosis (Davies disease) coincidental with systemic lupus erythematosus. ( 10855412 )
2000
16
Helminth associated hypereosinophilia and tropical endomyocardial fibrosis (EMF) in Nigeria. ( 9588233 )
1998
17
Pattern of cardiac calcification in tropical endomyocardial fibrosis. ( 2093711 )
1990
18
Cardiac ultrastructure in tropical endomyocardial fibrosis. ( 3397162 )
1988
19
Is malaria involved in the pathogenesis of tropical endomyocardial fibrosis? ( 3072819 )
1988
20
An autopsy study of tropical endomyocardial fibrosis in Kerala. ( 4093162 )
1985
21
Electron microscopic changes in tropical endomyocardial fibrosis. ( 6464108 )
1984
22
Immunological phenomena in tropical endomyocardial fibrosis. ( 6724630 )
1984
23
Skeletal muscle involvement in tropical endomyocardial fibrosis. ( 7077351 )
1982
24
Primary restrictive cardiomyopathy. Non-tropical endomyocardial fibrosis and hypereosinophilic heart disease. ( 869976 )
1977

Variations for Tropical Endomyocardial Fibrosis

Expression for Tropical Endomyocardial Fibrosis

Search GEO for disease gene expression data for Tropical Endomyocardial Fibrosis.

Pathways for Tropical Endomyocardial Fibrosis

Pathways related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(showing 37, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 IL10 IL4 TNF
2
Show member pathways
12.9 IL10 IL4 TNF
3
Show member pathways
12.51 IL10 IL4 TNF
4
Show member pathways
12.27 IL10 IL4 TNF
5
Show member pathways
12.22 IL10 IL4 TNF
6 12.17 IL10 IL4 TNF
7
Show member pathways
12.17 IL10 IL4 TNF
8 11.93 IL10 TNF
9
Show member pathways
11.91 IL10 TNF
10
Show member pathways
11.88 IL4 TNF
11
Show member pathways
11.88 IL10 IL4 TNF
12
Show member pathways
11.88 IL10 IL4 TNF
13 11.87 IL10 TNF
14
Show member pathways
11.76 IL10 TNF
15
Show member pathways
11.75 IL4 TNF
16 11.72 IL4 TNF
17 11.62 IL4 TNF
18 11.62 IL10 TNF
19 11.61 IL10 IL4 TNF
20 11.55 IL10 IL4 TNF
21
Show member pathways
11.51 IL4 TNF
22 11.5 IL10 TNF
23 11.49 IL10 TNF
24 11.41 IL10 IL4
25 11.4 IL4 TNF
26 11.34 IL10 IL4 TNF
27 11.28 IL10 TNF
28 11.24 IL10 IL4
29 11.18 IL10 IL4 TNF
30 11.14 IL10 TNF
31 11.1 IL10 TNF
32 11.05 IL4 TNF
33 10.94 IL10 IL4
34 10.82 IL10 IL4 TNF
35 10.81 IL10 IL4 TNF
36 10.66 IL10 IL4 TNF
37 10.26 IL10 IL4 TNF

GO Terms for Tropical Endomyocardial Fibrosis

Biological processes related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(showing 24, show less)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.79 IL10 IL4 TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.75 IL10 IL4 TNF
3 immune response GO:0006955 9.73 IL10 IL4 TNF
4 regulation of signaling receptor activity GO:0010469 9.7 IL10 IL4 TNF
5 cytokine-mediated signaling pathway GO:0019221 9.63 IL10 IL4 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.62 IL10 TNF
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.61 IL10 TNF
8 response to organic substance GO:0010033 9.6 IL10 TNF
9 B cell differentiation GO:0030183 9.59 IL10 IL4
10 response to glucocorticoid GO:0051384 9.58 IL10 TNF
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.57 IL10 TNF
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.55 IL10 IL4
13 negative regulation of mitotic cell cycle GO:0045930 9.54 IL10 TNF
14 negative regulation of interleukin-6 production GO:0032715 9.51 IL10 TNF
15 positive regulation of cytokine secretion GO:0050715 9.49 IL10 TNF
16 regulation of synapse organization GO:0050807 9.48 IL10 TNF
17 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 TNF
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 TNF
19 endothelial cell apoptotic process GO:0072577 9.37 IL10 TNF
20 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IL10 IL4
21 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 IL10 TNF
22 regulation of isotype switching GO:0045191 9.16 IL10 IL4
23 type 2 immune response GO:0042092 8.96 IL10 IL4
24 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Tropical Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.96 IL10 IL4
2 cytokine activity GO:0005125 8.8 IL10 IL4 TNF

Sources for Tropical Endomyocardial Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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