MCID: TRP002
MIFTS: 55

Tropical Spastic Paraparesis

Categories: Immune diseases, Infectious diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Tropical Spastic Paraparesis

MalaCards integrated aliases for Tropical Spastic Paraparesis:

Name: Tropical Spastic Paraparesis 12 77 55 15 17 74
Paraparesis, Tropical Spastic 45
Paraparesis Tropical Spastic 56
Tropical Spastic Paraplegia 12
Htlv-Associated Myelopathy 12
Tropical Spastic Paralysis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:321
MeSH 45 D015493
SNOMED-CT 69 45129002
ICD10 34 G04.1
UMLS 74 C0030481

Summaries for Tropical Spastic Paraparesis

NINDS : 55 For several decades the term “tropical spastic paraparesis” (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus — human T-cell lymphotrophic virus type 1 (also known as HTLV-1) — and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.

MalaCards based summary : Tropical Spastic Paraparesis, also known as paraparesis, tropical spastic, is related to htlv-1 associated myelopathy/tropical spastic paraparesis and t-cell leukemia. An important gene associated with Tropical Spastic Paraparesis is CNTN2 (Contactin 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Lamivudine and Zidovudine have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and eye, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and hematopoietic system

Disease Ontology : 12 A viral infectious disease that results in inflammation located in spinal cord, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

Wikipedia : 77 Tropical spastic paraparesis (TSP), also called HTLV-I-associated myelopathy (HAM) or HTLV-I-associated... more...

Related Diseases for Tropical Spastic Paraparesis

Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
# Related Disease Score Top Affiliating Genes
1 htlv-1 associated myelopathy/tropical spastic paraparesis 34.8 IFNL3 IL2
2 t-cell leukemia 31.0 CNTN2 IL2 IL2RA NFKB1
3 adult t-cell leukemia 31.0 CNTN2 FOXP3 IL2 IL2RA
4 prostatitis 30.4 IL10 IL2 IL6
5 cutaneous t cell lymphoma 30.3 IFNG IL2 IL2RA
6 folliculitis 30.3 CCL5 IFNG IL2RA
7 human t-cell leukemia virus type 2 30.2 CNTN2 IFNG NFKB1
8 multiple sclerosis 29.4 CCL5 CXCR3 FOXP3 IFNG IL10 IL2
9 human immunodeficiency virus type 1 29.3 CCL5 IFNG IL10 IL2 IL6 NFKB1
10 systemic lupus erythematosus 28.5 CCL5 CXCR3 FOXP3 IFNG IL10 IL2
11 myelopathy, htlv-1-associated 12.6
12 human t-cell leukemia virus type 1 11.8
13 retrovirus-associated myelopathy 11.6
14 spastic paraparesis 11.4
15 leukemia 10.8
16 dermatitis 10.6
17 lymphoma 10.5
18 nickel allergic contact dermatitis 10.5 IFNG IL10
19 baylisascariasis 10.5 IFNG IL10
20 sporotrichosis 10.5 IFNG IL10
21 berylliosis 10.5 IFNG IL2
22 atopic keratoconjunctivitis 10.5 IFNG IL2
23 apple allergy 10.5 FOXP3 IL10
24 scleritis 10.5 IFNG MMP9
25 angiostrongyliasis 10.4 IL2 MMP9
26 b-cell growth factor 10.4 IFNG IL6
27 funisitis 10.4 IL10 IL6
28 autoimmune enteropathy 10.4 FOXP3 IL2RA
29 neuropathy 10.4
30 extramedullary plasmacytoma 10.4 IL2 IL6
31 uremic pruritus 10.4 IL2 IL6
32 african tick-bite fever 10.4 CCL5 IFNG
33 cephalosporin allergy 10.4 IFNG IL10
34 vulvovaginitis 10.4 CCL5 IL10
35 anterior uveitis 10.4 IL2RA IL6
36 chromoblastomycosis 10.4 CXCR3 MMP9
37 variola major 10.4 IFNG IL2
38 acute necrotizing encephalitis 10.3 FOXP3 IFNG
39 clonorchiasis 10.3 IFNG IL10 IL2
40 hemophagocytic lymphohistiocytosis 10.3 IFNG IL10 IL2RA
41 chronic active epstein-barr virus infection 10.3 IFNG IL10 IL2
42 peripheral nervous system disease 10.3
43 infective dermatitis associated with htlv-1 10.3
44 autoimmune atherosclerosis 10.3 FOXP3 IL10
45 pancreas adenocarcinoma 10.3 FOXP3 IFNG MMP9
46 coccidiosis 10.3 IFNG IL10 IL2
47 leprosy 3 10.3 IFNG IL10 IL2
48 hyperlucent lung 10.3 IFNG IL10 IL2RA
49 autoimmune lymphoproliferative syndrome 10.3 IL10 IL2 IL2RA
50 lepromatous leprosy 10.3 IFNG IL10 IL2

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to Tropical Spastic Paraparesis

Symptoms & Phenotypes for Tropical Spastic Paraparesis

GenomeRNAi Phenotypes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression GR00224-A-2 8.8 MMP9 NFKB1 TNFRSF4

MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 CCL5 CXCR3 FOXP3 IFNG IFNL3 IL10
2 immune system MP:0005387 10.15 CCL5 CXCR3 FOXP3 IFNG IFNL3 IL10
3 cellular MP:0005384 10.13 CXCR3 FOXP3 IFNG IL10 IL2 IL6
4 digestive/alimentary MP:0005381 10.11 FOXP3 IFNG IL10 IL2 IL2RA IL6
5 homeostasis/metabolism MP:0005376 10.1 CXCR3 FOXP3 IFNG IL10 IL2 IL2RA
6 integument MP:0010771 9.87 FOXP3 IFNG IL10 IL6 MMP9 NFKB1
7 liver/biliary system MP:0005370 9.8 FOXP3 IFNG IL10 IL2 IL6 NFKB1
8 respiratory system MP:0005388 9.65 CXCR3 FOXP3 IFNG IL10 IL2 IL2RA
9 neoplasm MP:0002006 9.63 CXCR3 IFNG IL10 IL2 IL6 MMP9
10 vision/eye MP:0005391 9.17 FOXP3 IFNG IL10 IL2 IL2RA IL6

Drugs & Therapeutics for Tropical Spastic Paraparesis

Drugs for Tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
2
Zidovudine Approved Phase 2, Phase 3,Early Phase 1 30516-87-1 35370
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4
Valproic Acid Approved, Investigational Phase 3,Not Applicable 99-66-1 3121
5
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
6
Mogamulizumab Approved, Investigational Phase 3 1159266-37-1
7 Antiviral Agents Phase 2, Phase 3,Early Phase 1
8 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
9 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
10 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Early Phase 1
11 Reverse Transcriptase Inhibitors Phase 2, Phase 3,Early Phase 1
12 Antimetabolites Phase 2, Phase 3,Early Phase 1
13 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Early Phase 1
14 Dermatologic Agents Phase 2, Phase 3
15 Cyclosporins Phase 2, Phase 3
16 Antifungal Agents Phase 2, Phase 3
17 Immunologic Factors Phase 2, Phase 3
18 Calcineurin Inhibitors Phase 2, Phase 3
19 Immunosuppressive Agents Phase 2, Phase 3
20 Antirheumatic Agents Phase 2, Phase 3
21 Psychotropic Drugs Phase 3,Not Applicable
22 GABA Agents Phase 3,Not Applicable
23 Central Nervous System Depressants Phase 3,Not Applicable
24 Neurotransmitter Agents Phase 3,Not Applicable
25 Antimanic Agents Phase 3,Not Applicable
26 Anticonvulsants Phase 3,Not Applicable
27 Tranquilizing Agents Phase 3,Not Applicable
28 Protective Agents Phase 3
29 Radiation-Protective Agents Phase 3
30 Free Radical Scavengers Phase 3
31 Antioxidants Phase 3
32 Vasodilator Agents Phase 3
33 Platelet Aggregation Inhibitors Phase 3
34 Phosphodiesterase Inhibitors Phase 3
35
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
36
Infliximab Approved Phase 2 170277-31-3
37 Adjuvants, Immunologic Phase 2
38 interferons Phase 2
39 Interferon-beta Phase 2
40 Gastrointestinal Agents Phase 2
41 Antibodies, Monoclonal Phase 1
42 Immunoglobulins Phase 1
43 Antibodies Phase 1
44 Raltegravir Potassium Early Phase 1
45 Integrase Inhibitors Early Phase 1
46 HIV Integrase Inhibitors Early Phase 1

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
2 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
3 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
4 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
5 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Completed NCT00681980 Phase 3 Valproic acid;costicosteroids;valproid acid plus corticosteroids
6 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
7 A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM) Active, not recruiting NCT03191526 Phase 3 KW-0761 0.3 mg/kg IV;Placebo (saline)
8 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
9 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
10 Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM) Unknown status NCT02961712 Phase 1
11 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
12 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
13 Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection Completed NCT02655471 Early Phase 1 "Raltegravir" and "Zidovudine"
14 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
15 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
16 Raltegravir for HAM/TSP Completed NCT01867320 Early Phase 1 Raltegravir
17 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Completed NCT01651819 Not Applicable
18 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
19 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
20 Dual Algorithm Post Market Clinical Study Completed NCT03146013
21 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
22 Electromiography Study in the Respiratory Muscle Training in Human Lymphotropic Virus Type 1 Recruiting NCT03829709 Not Applicable
23 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Not Applicable Valproic Acid

Search NIH Clinical Center for Tropical Spastic Paraparesis

Cochrane evidence based reviews: paraparesis, tropical spastic

Genetic Tests for Tropical Spastic Paraparesis

Anatomical Context for Tropical Spastic Paraparesis

MalaCards organs/tissues related to Tropical Spastic Paraparesis:

42
T Cells, Spinal Cord, Eye, Skin, Brain, B Cells, Thyroid

Publications for Tropical Spastic Paraparesis

Articles related to Tropical Spastic Paraparesis:

(show top 50) (show all 441)
# Title Authors Year
1
Curcumin increased the expression of c-FLIP in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 31074052 )
2019
2
Functional capacity of natural killer cells in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 31101076 )
2019
3
Pain and Quality of Life in Human T-cell Lymphotropic Virus Type 1-Associated Myelopathy or Tropical Spastic Paraparesis After Home-Based Exercise Protocol: A Randomized Clinical Trial. ( 31038621 )
2019
4
Neuroimmunology of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 31105674 )
2019
5
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2018
6
Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 30341468 )
2018
7
Role of Integrin Signaling Activation on the Development of Human T Cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-Infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
8
Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010). ( 29554087 )
2018
9
Proposal of Classification Criteria for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Disease Activity. ( 30090093 )
2018
10
Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 28965354 )
2018
11
Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 29292042 )
2018
12
Balance, functional mobility, and fall occurrence in patients with human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis: a cross-sectional study. ( 29768548 )
2018
13
Early Juvenile Human T-cell Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Study of 25 Patients. ( 29912303 )
2018
14
Interferon Lambda Family along with HTLV-1 Proviral Load, Tax, and HBZ Implicated in the Pathogenesis of Myelopathy/Tropical Spastic Paraparesis. ( 29990995 )
2018
15
Human T-Lymphotropic Virus-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age. ( 30181035 )
2018
16
Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil. ( 30466392 )
2018
17
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
18
Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 28095504 )
2017
19
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. ( 28101786 )
2017
20
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 28378248 )
2017
21
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
22
Mediators Go Together: High Production of CXCL9, CXCL10, IFN-γ, and TNF-α in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28648091 )
2017
23
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 29202792 )
2017
24
Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 26756420 )
2017
25
Indigenous tropical spastic paraparesis in Madrid (Spain). Experience on screening of human T-lymphotropic virus. ( 26282070 )
2017
26
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
27
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: The First Case Report in Southeast Asia. ( 28343405 )
2017
28
Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis from the Brazilian Amazon. ( 28380116 )
2017
29
IL17A Polymorphism Is Not Associated with Human T-Lymphotropic Virus 1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28410448 )
2017
30
Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study. ( 28536850 )
2017
31
Central motor pathways in tropical spastic paraparesis: a combined transcranial magnetic stimulation and diffusion tensor imaging study. ( 30944510 )
2017
32
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. ( 26169165 )
2016
33
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 27028551 )
2016
34
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
35
Tax secretion from peripheral blood mononuclear cells and Tax detection in plasma of patients with human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis and asymptomatic carriers. ( 26241614 )
2016
36
Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers. ( 26472535 )
2016
37
HLA-G 3'-untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development. ( 27449667 )
2016
38
Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation. ( 27777805 )
2016
39
Clonus Associated with Tropical Spastic Paraparesis. ( 27783915 )
2016
40
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8+ T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. ( 26077665 )
2015
41
HTLV-1-associated myelopathy/tropical spastic paraparesis and peripheral neuropathy following live-donor renal transplantation. ( 25196582 )
2015
42
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 25470342 )
2015
43
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. ( 25820277 )
2015
44
Editorial Commentary: Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25820278 )
2015
45
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
46
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26156876 )
2015
47
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
48
Common γ-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26283355 )
2015
49
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26392440 )
2015
50
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. ( 26609200 )
2015

Variations for Tropical Spastic Paraparesis

Expression for Tropical Spastic Paraparesis

Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for Tropical Spastic Paraparesis

Pathways related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 CCL5 IFNG IFNL3 IL10 IL2 IL2RA
2
Show member pathways
13.6 CCL5 CXCR3 IFNG IFNL3 IL10 IL2
3
Show member pathways
13.52 CCL5 IFNG IL10 IL2 IL2RA IL6
4
Show member pathways
13.39 CCL5 CXCR3 IL10 IL2 IL2RA IL6
5
Show member pathways
13.26 CCL5 CXCR3 IL10 IL2 IL2RA IL6
6
Show member pathways
13.21 CCL5 IFNG IFNL3 IL10 IL2 IL2RA
7
Show member pathways
13.09 CCL5 IFNG IL10 IL2 IL6 NFKB1
8 12.83 IFNG IL2 IL2RA IL6 MMP9 NFKB1
9
Show member pathways
12.82 FOXP3 IFNG IL10 IL2 IL2RA IL6
10
Show member pathways
12.77 CCL5 IFNG IFNL3 IL6 NFKB1
11
Show member pathways
12.64 IFNG IL10 IL2 IL2RA NFKB1
12
Show member pathways
12.6 IFNG IL10 IL2 IL6 NFKB1
13
Show member pathways
12.56 IFNG IL10 IL2 IL6 NFKB1
14
Show member pathways
12.54 FOXP3 IFNG IL10 IL2 IL2RA IL6
15
Show member pathways
12.51 IFNG IL2 KIR2DL3 KLRK1
16
Show member pathways
12.37 IFNG IFNL3 IL10 IL2 IL2RA IL6
17 12.37 CCL5 FOXP3 IFNG IL10 IL2 IL2RA
18 12.36 IL2 IL2RA IL6 NFKB1
19
Show member pathways
12.34 IFNG IL6 MMP9 NFKB1
20
Show member pathways
12.34 CCL5 IFNG IL2 IL6 NFKB1
21
Show member pathways
12.28 IFNG IL10 IL2 IL2RA IL6
22 12.25 IFNG IL10 IL6 NFKB1
23
Show member pathways
12.23 IL10 IL2 IL6 NFKB1
24 12.21 IFNG IL6 MMP9 NFKB1
25
Show member pathways
12.08 IFNG IL10 IL2 IL6
26 12.06 IFNG MMP9 NFKB1
27
Show member pathways
12.05 IFNG IL2 IL2RA
28 12.04 IFNG IL2 IL6 MMP9
29
Show member pathways
12.04 CCL5 IFNG IL10 IL2 IL2RA IL6
30
Show member pathways
12.02 IFNG IL6 MMP9
31
Show member pathways
12.01 IL2 IL2RA NFKB1
32
Show member pathways
12 IFNG IL2 IL2RA NFKB1
33 11.99 CCL5 IL6 MMP9 NFKB1
34 11.97 IL10 IL6 MMP9
35
Show member pathways
11.94 IL2 IL2RA NFKB1
36 11.91 IFNG IL6 NFKB1
37 11.91 IFNG IL10 IL6 NFKB1
38 11.91 IFNG IL10 IL2 IL2RA IL6 KLRK1
39
Show member pathways
11.87 FOXP3 IL6 NFKB1
40 11.86 CCL5 IFNG IL6
41 11.85 IFNG IL10 IL2 IL2RA IL6
42 11.84 IFNG IL6 NFKB1
43 11.83 IFNG IL2 IL6 NFKB1
44
Show member pathways
11.79 FOXP3 IFNG IL2 IL2RA
45 11.77 IL10 IL6 NFKB1
46 11.77 IFNG IL10 IL2 IL6
47 11.71 IFNG IL2 NFKB1
48
Show member pathways
11.71 FOXP3 IL2 IL2RA NFKB1
49 11.7 IL6 MMP9 NFKB1
50 11.7 CXCR3 IFNG IL10 IL2 IL2RA KLRK1

GO Terms for Tropical Spastic Paraparesis

Cellular components related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 CCL5 IFNG IFNL3 IL10 IL2 IL6
2 external side of plasma membrane GO:0009897 9.56 CXCR3 IL2RA KLRK1 TNFRSF4
3 cell surface GO:0009986 9.35 CNTN2 CXCR3 IL2RA KLRK1 TNFRSF4
4 extracellular region GO:0005576 9.23 CCL5 IFNG IFNL3 IL10 IL2 IL6

Biological processes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 IL10 IL2 IL6 MMP9 NFKB1
2 regulation of signaling receptor activity GO:0010469 9.95 CCL5 IFNG IFNL3 IL10 IL2 IL6
3 inflammatory response GO:0006954 9.91 CCL5 CXCR3 IL10 IL6 NFKB1 TNFRSF4
4 cellular response to lipopolysaccharide GO:0071222 9.83 IL10 IL6 KLRK1 NFKB1
5 response to virus GO:0009615 9.77 CCL5 FOXP3 IFNG
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.76 CCL5 IFNG IL2 IL6
7 negative regulation of T cell proliferation GO:0042130 9.69 FOXP3 IL10 IL2RA
8 positive regulation of T cell proliferation GO:0042102 9.67 CCL5 IL2 IL2RA IL6
9 negative regulation of inflammatory response GO:0050728 9.65 FOXP3 IL10 IL2 IL2RA NFKB1
10 positive regulation of T cell differentiation GO:0045582 9.61 IL2 IL2RA
11 negative regulation of immune response GO:0050777 9.59 FOXP3 IL2RA
12 negative regulation of cytokine secretion GO:0050710 9.58 FOXP3 TNFRSF4
13 negative regulation of interleukin-17 production GO:0032700 9.58 FOXP3 IFNG
14 positive regulation of immunoglobulin secretion GO:0051024 9.58 IL2 IL6 TNFRSF4
15 positive regulation of regulatory T cell differentiation GO:0045591 9.57 FOXP3 IL2
16 interleukin-2-mediated signaling pathway GO:0038110 9.56 IL2 IL2RA
17 negative regulation of T-helper 17 cell differentiation GO:2000320 9.54 FOXP3 IL2
18 negative regulation of lymphocyte proliferation GO:0050672 9.5 FOXP3 IL2 IL2RA
19 cytokine-mediated signaling pathway GO:0019221 9.5 CCL5 IFNL3 IL10 IL2 IL2RA IL6
20 regulation of T cell homeostatic proliferation GO:0046013 9.49 IL2 IL2RA
21 regulation of regulatory T cell differentiation GO:0045589 9.46 FOXP3 IFNG IL2 IL2RA
22 immune response GO:0006955 9.28 CCL5 CXCR3 IFNG IL10 IL2 IL2RA

Molecular functions related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CCL5 IFNG IFNL3 IL10 IL2 IL6

Sources for Tropical Spastic Paraparesis

3 CDC
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