MCID: TRP002
MIFTS: 57

Tropical Spastic Paraparesis

Categories: Neuronal diseases, Infectious diseases

Aliases & Classifications for Tropical Spastic Paraparesis

MalaCards integrated aliases for Tropical Spastic Paraparesis:

Name: Tropical Spastic Paraparesis 12 76 54 15 73
Paraparesis, Tropical Spastic 44
Paraparesis Tropical Spastic 55
Tropical Spastic Paraplegia 12
Htlv-Associated Myelopathy 12
Tropical Spastic Paralysis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:321
ICD10 33 G04.1
MeSH 44 D015493
UMLS 73 C0030481

Summaries for Tropical Spastic Paraparesis

NINDS : 54 For several decades the term “tropical spastic paraparesis” (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus — human T-cell lymphotrophic virus type 1 (also known as HTLV-1) — and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.

MalaCards based summary : Tropical Spastic Paraparesis, also known as paraparesis, tropical spastic, is related to adult t-cell leukemia and cutaneous t cell lymphoma, and has symptoms including spastic weakness of both legs, muscle stiffness and sensory disturbance. An important gene associated with Tropical Spastic Paraparesis is CNTN2 (Contactin 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Lamivudine and Zidovudine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, t cells and spinal cord, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and hematopoietic system

Disease Ontology : 12 A viral infectious disease that results in inflammation located in spinal cord, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

Wikipedia : 76 Tropical spastic paraparesis (TSP), also called HTLV-I-associated myelopathy (HAM) or HTLV-I-associated... more...

Related Diseases for Tropical Spastic Paraparesis

Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 adult t-cell leukemia 31.0 CNTN2 FOXP3 IL2 IL2RA
2 cutaneous t cell lymphoma 30.5 IFNG IL2 IL2RA
3 t-cell leukemia 30.5 CNTN2 IL2 IL2RA TNFRSF4
4 folliculitis 30.5 CCL5 IFNG IL2RA
5 human immunodeficiency virus type 1 28.6 CCL5 IFNG IL10 IL2 IL6 NFKB1
6 psoriasis 27.2 CCL5 CXCR3 IFNG IL10 IL17A IL2
7 systemic lupus erythematosus 26.6 CCL5 CXCR3 IFNG IL10 IL17A IL2
8 multiple sclerosis 26.3 CCL5 CXCR3 FOXP3 IFNG IL10 IL17A
9 htlv-1 associated myelopathy/tropical spastic paraparesis 12.7
10 myelopathy, htlv-1-associated 12.4
11 human t-cell leukemia virus type 1 11.5
12 retrovirus-associated myelopathy 11.5
13 spastic paraparesis 11.2
14 spasticity 11.2
15 type i 10.9
16 variola major 10.8 IFNG IL2
17 acute necrotizing encephalitis 10.8 FOXP3 IFNG
18 autoimmune myocarditis 10.8 IFNG IL2
19 fixed drug eruption 10.8 IFNG IL2
20 berylliosis 10.8 IFNG IL2
21 sporotrichosis 10.7 IFNG IL10
22 baylisascariasis 10.7 IFNG IL10
23 eye lymphoma 10.7 IL10 IL6
24 leukemia 10.7
25 clonorchiasis 10.6 IFNG IL10 IL2
26 chronic active epstein-barr virus infection 10.6 IFNG IL10 IL2
27 coccidiosis 10.6 IFNG IL10 IL2
28 b-cell growth factor 10.6 IFNG IL6
29 lepromatous leprosy 10.6 IFNG IL10 IL2
30 diabetic foot ulcers 10.6 IL6 MMP9
31 herpes zoster 10.6 IFNG IL10 IL2
32 hyperlucent lung 10.6 IFNG IL10 IL2RA
33 leprosy 3 10.6 IFNG IL10 IL2
34 streptococcal toxic-shock syndrome 10.6 IL2 IL6
35 african tick-bite fever 10.6 CCL5 IFNG
36 chronic graft versus host disease 10.6 IFNG IL10 IL2RA
37 extramedullary plasmacytoma 10.6 IL2 IL6
38 scorpion envenomation 10.6 CCL5 IL6
39 autoimmune disease of endocrine system 10.6 FOXP3 IFNG IL2
40 food allergy 10.6 FOXP3 IFNG IL10
41 schistosomiasis 10.6 IFNG IL10 IL2
42 cutaneous leishmaniasis 10.6 FOXP3 IFNG IL10
43 multicentric castleman disease 10.5 IFNG IL10 IL6
44 posterior uveitis 10.5 IFNG IL2 IL2RA
45 atopic keratoconjunctivitis 10.5 IFNG IL2
46 hand, foot and mouth disease 10.5 IFNG IL10 IL6
47 myasthenia gravis 10.5 IFNG IL10 IL2
48 eales disease 10.5 IFNG IL10 IL6
49 hemorrhagic fever 10.5 IFNG IL10 IL6
50 pulmonary tuberculosis 10.5 IFNG IL10 IL2

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to Tropical Spastic Paraparesis

Symptoms & Phenotypes for Tropical Spastic Paraparesis

Symptoms:

12
  • spastic weakness of both legs
  • muscle stiffness
  • sensory disturbance
  • spasms

GenomeRNAi Phenotypes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression GR00224-A-2 8.8 MMP9 NFKB1 TNFRSF4

MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.32 IL2 MMP9 IL2RA NFKB1 IL6 IFNL3
2 immune system MP:0005387 10.28 IL2 MMP9 IL2RA NFKB1 IL6 IFNL3
3 cellular MP:0005384 10.24 IL6 IL2 MMP9 NFKB1 FOXP3 IL10
4 growth/size/body region MP:0005378 10.24 IL17A IL6 IL2 MMP9 IL2RA FOXP3
5 digestive/alimentary MP:0005381 10.22 IL6 IL2 MMP9 IL2RA NFKB1 FOXP3
6 homeostasis/metabolism MP:0005376 10.2 IL17A IL6 IL2 MMP9 IL2RA NFKB1
7 endocrine/exocrine gland MP:0005379 10.11 IL17A IL6 IL2 IL2RA NFKB1 FOXP3
8 mortality/aging MP:0010768 10.06 IL17A IL6 IL2 MMP9 IL2RA NFKB1
9 integument MP:0010771 9.95 IL6 MMP9 NFKB1 FOXP3 IL10 TNFRSF4
10 liver/biliary system MP:0005370 9.91 IL6 IL2 NFKB1 FOXP3 IL10 TNFRSF4
11 neoplasm MP:0002006 9.73 IL6 IL2 MMP9 CXCR3 IL10 IFNG
12 respiratory system MP:0005388 9.7 IL2 MMP9 IL2RA NFKB1 IL6 FOXP3
13 renal/urinary system MP:0005367 9.63 IL17A IL6 MMP9 CXCR3 FOXP3 IFNG
14 vision/eye MP:0005391 9.23 IL6 IL2 MMP9 IL2RA FOXP3 IL10

Drugs & Therapeutics for Tropical Spastic Paraparesis

Drugs for Tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
2
Zidovudine Approved Phase 2, Phase 3,Early Phase 1 30516-87-1 35370
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4
Valproic Acid Approved, Investigational Phase 3,Not Applicable 99-66-1 3121
5
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
6 Central Nervous System Depressants Phase 3,Not Applicable
7 Reverse Transcriptase Inhibitors Phase 2, Phase 3,Early Phase 1
8 GABA Agents Phase 3,Not Applicable
9 Neurotransmitter Agents Phase 3,Not Applicable
10 Cyclosporins Phase 2, Phase 3
11 Dermatologic Agents Phase 2, Phase 3
12 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Early Phase 1
13 Tranquilizing Agents Phase 3,Not Applicable
14 Vasodilator Agents Phase 3
15 Phosphodiesterase Inhibitors Phase 3
16 Platelet Aggregation Inhibitors Phase 3
17 Immunosuppressive Agents Phase 2, Phase 3
18 Anticonvulsants Phase 3,Not Applicable
19 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Early Phase 1
20 Antifungal Agents Phase 2, Phase 3
21 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
22 Antioxidants Phase 3
23 Protective Agents Phase 3
24 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
25 Psychotropic Drugs Phase 3,Not Applicable
26 Radiation-Protective Agents Phase 3
27 Antimanic Agents Phase 3,Not Applicable
28 Antirheumatic Agents Phase 2, Phase 3
29 Antimetabolites Phase 2, Phase 3,Early Phase 1
30 Antiviral Agents Phase 2, Phase 3,Early Phase 1
31 Calcineurin Inhibitors Phase 2, Phase 3
32
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
33
Infliximab Approved Phase 2 170277-31-3
34 interferons Phase 2
35 Adjuvants, Immunologic Phase 2
36 Interferon-beta Phase 2
37 Gastrointestinal Agents Phase 2
38 Antibodies Phase 1
39 Immunoglobulins Phase 1
40 Antibodies, Monoclonal Phase 1
41 Raltegravir Potassium Early Phase 1
42 HIV Integrase Inhibitors Early Phase 1
43 Integrase Inhibitors Early Phase 1

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
2 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
3 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
4 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
5 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Completed NCT00681980 Phase 3 Valproic acid;costicosteroids;valproid acid plus corticosteroids
6 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
7 A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM) Active, not recruiting NCT03191526 Phase 3 KW-0761 0.3 mg/kg IV;Placebo (saline)
8 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
9 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
10 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
11 Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM) Recruiting NCT02961712 Phase 1
12 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Unknown status NCT01651819 Not Applicable
13 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
14 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
15 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
16 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
17 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
18 Dual Algorithm Post Market Clinical Study Completed NCT03146013
19 Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection Recruiting NCT02655471 Early Phase 1 "Raltegravir" and "Zidovudine"
20 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
21 Raltegravir for HAM/TSP Active, not recruiting NCT01867320 Early Phase 1 Raltegravir
22 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Not Applicable Valproic Acid

Search NIH Clinical Center for Tropical Spastic Paraparesis

Cochrane evidence based reviews: paraparesis, tropical spastic

Genetic Tests for Tropical Spastic Paraparesis

Anatomical Context for Tropical Spastic Paraparesis

The Foundational Model of Anatomy Ontology organs/tissues related to Tropical Spastic Paraparesis:

19
Spinal Cord

MalaCards organs/tissues related to Tropical Spastic Paraparesis:

41
T Cells, Spinal Cord, Skin, Eye, Lung, Brain, Nk Cells

Publications for Tropical Spastic Paraparesis

Articles related to Tropical Spastic Paraparesis:

(show top 50) (show all 424)
# Title Authors Year
1
Balance, functional mobility, and fall occurrence in patients with human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis: a cross-sectional study. ( 29768548 )
2018
2
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
3
Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010). ( 29554087 )
2018
4
Early Juvenile HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP): Study of 25 Patients. ( 29912303 )
2018
5
Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 28965354 )
2018
6
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 28378248 )
2017
7
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
8
Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study. ( 28536850 )
2017
9
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
10
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. ( 28101786 )
2017
11
Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis from the Brazilian Amazon. ( 28380116 )
2017
12
Indigenous tropical spastic paraparesis in Madrid (Spain). Experience on screening of human T-lymphotropic virus. ( 26282070 )
2017
13
Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 29292042 )
2017
14
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 29202792 )
2017
15
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2017
16
IL17A Polymorphism Is Not Associated with Human T-Lymphotropic Virus 1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28410448 )
2017
17
Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 28095504 )
2017
18
Mediators Go Together: High Production of CXCL9, CXCL10, IFN-I^, and TNF-I+ in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28648091 )
2017
19
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: The First Case Report in Southeast Asia. ( 28343405 )
2017
20
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
21
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 27028551 )
2016
22
Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation. ( 27777805 )
2016
23
HLA-G 3' untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development. ( 27449667 )
2016
24
Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 26756420 )
2016
25
Clonus Associated with Tropical Spastic Paraparesis. ( 27783915 )
2016
26
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
27
Electrophysiological Analysis Shows Dizziness as the First Symptom in Human T Cell Lymphotropic Virus Type-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25760424 )
2015
28
Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25820278 )
2015
29
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26156876 )
2015
30
High IFN-I^/IL-10 Expression Ratio and Increased Frequency of Persistent Human T-Cell Lymphotropic Virus Type 1-Infected Clones Are Associated with Human T-Cell Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Development. ( 25833232 )
2015
31
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. ( 26169165 )
2015
32
Common I^-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26283355 )
2015
33
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. ( 25820277 )
2015
34
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8(+) T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. ( 26077665 )
2015
35
Postrenal Transplant Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis: A Case Report and Review of the Literature. ( 27500208 )
2015
36
HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 27188208 )
2015
37
Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers. ( 26472535 )
2015
38
Tax secretion from peripheral blood mononuclear cells and tax detection in plasma of patients with human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis and asymptomatic carriers. ( 26241614 )
2015
39
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
40
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. ( 26609200 )
2015
41
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
42
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 25470342 )
2015
43
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26392440 )
2015
44
Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 24704970 )
2014
45
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. ( 25229227 )
2014
46
Proprioceptive neuromuscular facilitation in HTLV-I-associated myelopathy/tropical spastic paraparesis. ( 24603733 )
2014
47
Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 24802839 )
2014
48
HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis: Semiautomatic Quantification of Spinal Cord Atrophy from 3-Dimensional MR Images. ( 22303896 )
2014
49
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis. ( 24472094 )
2014
50
Temporal lesions and widespread involvement of white matter associated with multi-organ inflammatory disease in human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 24815740 )
2014

Variations for Tropical Spastic Paraparesis

Expression for Tropical Spastic Paraparesis

Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for Tropical Spastic Paraparesis

Pathways related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CCL5 IFNG IFNL3 IL10 IL17A IL2
2
Show member pathways
13.84 CCL5 CXCR3 IL10 IL17A IL2 IL2RA
3
Show member pathways
13.59 CCL5 CXCR3 IFNG IFNL3 IL10 IL17A
4
Show member pathways
13.5 CCL5 IFNG IL10 IL17A IL2 IL2RA
5
Show member pathways
13.36 CCL5 CXCR3 IL10 IL17A IL2 IL2RA
6
Show member pathways
13.22 CCL5 IFNG IFNL3 IL10 IL17A IL2
7
Show member pathways
13.17 CCL5 CXCR3 IL10 IL17A IL2 IL2RA
8
Show member pathways
13.02 CCL5 IFNG IL10 IL2 IL6 NFKB1
9 12.85 IFNG IL2 IL2RA IL6 MMP9 NFKB1
10
Show member pathways
12.82 FOXP3 IFNG IL10 IL17A IL2 IL2RA
11
Show member pathways
12.8 CCL5 IFNG IL2 IL2RA IL6 NFKB1
12
Show member pathways
12.78 CCL5 IFNG IFNL3 IL6 NFKB1
13
Show member pathways
12.59 IFNG IL10 IL17A IL2 IL6 NFKB1
14
Show member pathways
12.57 IFNG IFNL3 IL10 IL17A IL2 IL2RA
15 12.43 IL2 IL2RA IL6 NFKB1
16
Show member pathways
12.42 IFNG IL10 IL17A IL2 IL6 NFKB1
17
Show member pathways
12.35 CCL5 IFNG IL2 IL6 NFKB1
18
Show member pathways
12.35 IFNG IL17A IL6 MMP9 NFKB1
19 12.26 IFNG IL10 IL6 NFKB1
20
Show member pathways
12.26 IFNG IL10 IL17A IL2 IL6
21
Show member pathways
12.24 IL10 IL2 IL6 NFKB1
22 12.21 IFNG IL6 MMP9 NFKB1
23
Show member pathways
12.18 FOXP3 IFNG IL10 IL17A IL2 IL2RA
24 12.06 IFNG MMP9 NFKB1
25 12.06 IFNG IL2 IL6 MMP9
26
Show member pathways
12.05 CCL5 IFNG IL10 IL17A IL2 IL2RA
27
Show member pathways
12.04 IFNG IL2 IL2RA
28 12.03 IL10 IL17A IL6 MMP9
29
Show member pathways
12.02 IFNG IL2 IL2RA NFKB1
30 12.01 IFNG IL10 IL2 IL2RA IL6
31
Show member pathways
12 IL2 IL2RA NFKB1
32 11.99 CCL5 IL6 MMP9 NFKB1
33
Show member pathways
11.94 IL2 IL2RA NFKB1
34 11.93 IFNG IL10 IL6 NFKB1
35
Show member pathways
11.91 FOXP3 IL17A IL6 NFKB1
36 11.91 IFNG IL10 IL2 IL2RA IL6
37 11.9 IFNG IL6 NFKB1
38 11.89 CCL5 IFNG IL17A IL6
39 11.84 IFNG IL6 NFKB1
40 11.84 IFNG IL2 IL6 NFKB1
41
Show member pathways
11.79 FOXP3 IFNG IL2 IL2RA
42 11.79 CCL5 FOXP3 IFNG IL10 IL17A IL2
43 11.78 IL10 IL6 NFKB1
44 11.78 IFNG IL10 IL2 IL6
45
Show member pathways
11.73 FOXP3 IL2 IL2RA NFKB1
46 11.72 IFNG IL2 NFKB1
47 11.71 IL6 MMP9 NFKB1
48 11.7 CXCR3 IFNG IL10 IL17A IL2 IL2RA
49 11.69 CCL5 IL6 MMP9
50
Show member pathways
11.67 IFNG IL2 IL2RA TNFRSF4

GO Terms for Tropical Spastic Paraparesis

Cellular components related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CCL5 IFNG IFNL3 IL10 IL17A IL2
2 extracellular region GO:0005576 9.28 CCL5 IFNG IFNL3 IL10 IL17A IL2

Biological processes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.96 IL10 IL2 IL6 MMP9 NFKB1
2 regulation of signaling receptor activity GO:0010469 9.87 CCL5 IFNG IFNL3 IL10 IL17A IL2
3 cellular response to lipopolysaccharide GO:0071222 9.8 IL10 IL6 NFKB1
4 response to virus GO:0009615 9.78 CCL5 FOXP3 IFNG
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.78 CCL5 IFNG IL2 IL6
6 negative regulation of inflammatory response GO:0050728 9.77 FOXP3 IL10 IL2 IL2RA NFKB1
7 positive regulation of T cell proliferation GO:0042102 9.76 CCL5 IL2 IL2RA IL6
8 immune response GO:0006955 9.76 CCL5 IFNG IL10 IL17A IL2 IL2RA
9 cellular response to interleukin-1 GO:0071347 9.72 CCL5 IL17A NFKB1
10 negative regulation of T cell proliferation GO:0042130 9.69 FOXP3 IL10 IL2RA
11 positive regulation of osteoclast differentiation GO:0045672 9.62 IFNG IL17A
12 positive regulation of T cell differentiation GO:0045582 9.62 IL2 IL2RA
13 positive regulation of immunoglobulin secretion GO:0051024 9.61 IL2 IL6 TNFRSF4
14 negative regulation of interleukin-17 production GO:0032700 9.59 FOXP3 IFNG
15 regulation of T cell activation GO:0050863 9.58 CCL5 IFNL3
16 interleukin-2-mediated signaling pathway GO:0038110 9.58 IL2 IL2RA
17 negative regulation of lymphocyte proliferation GO:0050672 9.58 FOXP3 IL2 IL2RA
18 positive regulation of regulatory T cell differentiation GO:0045591 9.57 FOXP3 IL2
19 regulation of regulatory T cell differentiation GO:0045589 9.56 FOXP3 IFNG IL2 IL2RA
20 inflammatory response GO:0006954 9.56 CCL5 CXCR3 IL10 IL17A IL2RA IL6
21 negative regulation of T-helper 17 cell differentiation GO:2000320 9.54 FOXP3 IL2
22 positive regulation of interleukin-23 production GO:0032747 9.52 IFNG IL17A
23 regulation of T cell homeostatic proliferation GO:0046013 9.49 IL2 IL2RA
24 cytokine-mediated signaling pathway GO:0019221 9.23 CCL5 IFNL3 IL10 IL17A IL2 IL2RA
25 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 FOXP3 IL10 IL17A IL2 IL6 NFKB1
26 apoptotic process GO:0006915 10.01 CXCR3 IFNG IL17A IL2RA NFKB1

Molecular functions related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL5 IFNG IFNL3 IL10 IL17A IL2

Sources for Tropical Spastic Paraparesis

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