MCID: TRP002
MIFTS: 55

Tropical Spastic Paraparesis

Categories: Immune diseases, Infectious diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Tropical Spastic Paraparesis

MalaCards integrated aliases for Tropical Spastic Paraparesis:

Name: Tropical Spastic Paraparesis 12 76 54 15 73
Paraparesis, Tropical Spastic 44
Paraparesis Tropical Spastic 55
Tropical Spastic Paraplegia 12
Htlv-Associated Myelopathy 12
Tropical Spastic Paralysis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:321
ICD10 33 G04.1
MeSH 44 D015493
SNOMED-CT 68 45129002
UMLS 73 C0030481

Summaries for Tropical Spastic Paraparesis

NINDS : 54 For several decades the term “tropical spastic paraparesis” (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus — human T-cell lymphotrophic virus type 1 (also known as HTLV-1) — and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.

MalaCards based summary : Tropical Spastic Paraparesis, also known as paraparesis, tropical spastic, is related to htlv-1 associated myelopathy/tropical spastic paraparesis and t-cell leukemia. An important gene associated with Tropical Spastic Paraparesis is CNTN2 (Contactin 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Zidovudine and Lamivudine have been mentioned in the context of this disorder. Affiliated tissues include t cells, spinal cord and skin, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and hematopoietic system

Disease Ontology : 12 A viral infectious disease that results in inflammation located in spinal cord, has material basis in Human T-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms.

Wikipedia : 76 Tropical spastic paraparesis (TSP), also called HTLV-I-associated myelopathy (HAM) or HTLV-I-associated... more...

Related Diseases for Tropical Spastic Paraparesis

Diseases related to Tropical Spastic Paraparesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 265)
# Related Disease Score Top Affiliating Genes
1 htlv-1 associated myelopathy/tropical spastic paraparesis 34.2 CXCR3 FOXP3 IFNL3 IL2RA
2 t-cell leukemia 31.1 CNTN2 IL2 IL2RA NFKB1
3 adult t-cell leukemia 30.9 CNTN2 FOXP3 IL2 IL2RA
4 cutaneous t cell lymphoma 30.3 IFNG IL2 IL2RA
5 prostatitis 30.2 IL10 IL2 IL6
6 folliculitis 30.2 CCL5 IFNG IL2RA
7 lyme disease 30.0 IL17A IL6 MMP9
8 viral infectious disease 29.9 CCL5 IFNG IL10 IL2 IL6
9 multiple sclerosis 29.5 CCL5 CXCR3 FOXP3 IFNG IL10 IL17A
10 human immunodeficiency virus type 1 29.4 CCL5 HLA-B IFNG IL10 IL2 IL6
11 psoriasis 29.3 CCL5 CXCR3 IFNG IL10 IL17A IL2
12 systemic lupus erythematosus 28.5 CCL5 CXCR3 FOXP3 IFNG IL10 IL17A
13 myelopathy, htlv-1-associated 12.6
14 human t-cell leukemia virus type 1 11.7
15 retrovirus-associated myelopathy 11.6
16 spastic paraparesis 11.4
17 leukemia 10.8
18 dermatitis 10.6
19 neuropathy 10.4
20 nickel allergic contact dermatitis 10.3 IFNG IL10
21 baylisascariasis 10.3 IFNG IL10
22 penicillin allergy 10.3 IFNG IL10
23 sporotrichosis 10.3 IFNG IL10
24 microscopic polyangiitis 10.3 HLA-B IL10
25 variola major 10.3 IFNG IL2
26 berylliosis 10.3 IFNG IL2
27 gaucher disease, type ii 10.3 IL10 IL2
28 atopic keratoconjunctivitis 10.3 IFNG IL2
29 fixed drug eruption 10.3 IFNG IL2
30 acute necrotizing encephalitis 10.3 FOXP3 IFNG
31 autoimmune atherosclerosis 10.3 FOXP3 IL10
32 apple allergy 10.3 FOXP3 IL10
33 lymphoma 10.3
34 peripheral nervous system disease 10.3
35 infective dermatitis associated with htlv-1 10.3
36 scleritis 10.3 IFNG MMP9
37 large granular lymphocyte leukemia 10.3 IFNG IL2RA
38 b-cell growth factor 10.3 IFNG IL6
39 angiostrongyliasis 10.3 IL2 MMP9
40 funisitis 10.3 IL10 IL6
41 eye lymphoma 10.3 IL10 IL6
42 african tick-bite fever 10.2 CCL5 IFNG
43 vulvovaginitis 10.2 CCL5 IL10
44 uremic pruritus 10.2 IL2 IL6
45 streptococcal toxic-shock syndrome 10.2 IL2 IL6
46 diabetic foot ulcers 10.2 IL6 MMP9
47 trichosporonosis 10.2 IFNG IL17A
48 palladium allergic contact dermatitis 10.2 IL10 IL17A
49 neurosyphilis 10.2 IL10 IL17A
50 myasthenia gravis 10.2 IFNG IL10 IL2

Graphical network of the top 20 diseases related to Tropical Spastic Paraparesis:



Diseases related to Tropical Spastic Paraparesis

Symptoms & Phenotypes for Tropical Spastic Paraparesis

GenomeRNAi Phenotypes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression GR00224-A-2 8.8 MMP9 NFKB1 TNFRSF4

MGI Mouse Phenotypes related to Tropical Spastic Paraparesis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.29 CCL5 CXCR3 FOXP3 IFNG IFNL3 IL10
2 immune system MP:0005387 10.25 CCL5 CXCR3 FOXP3 IFNG IFNL3 IL10
3 digestive/alimentary MP:0005381 10.22 FOXP3 IFNG IL10 IL17A IL2 IL2RA
4 homeostasis/metabolism MP:0005376 10.2 CXCR3 FOXP3 IFNG IL10 IL17A IL2
5 cellular MP:0005384 10.19 CXCR3 FOXP3 IFNG IL10 IL2 IL6
6 growth/size/body region MP:0005378 10.19 FOXP3 IFNG IL10 IL17A IL2 IL2RA
7 endocrine/exocrine gland MP:0005379 10.11 FOXP3 IFNG IL10 IL17A IL2 IL2RA
8 mortality/aging MP:0010768 10.06 CXCR3 FOXP3 IFNG IL10 IL17A IL2
9 integument MP:0010771 9.95 FOXP3 IFNG IL10 IL6 MMP9 NFKB1
10 liver/biliary system MP:0005370 9.91 FOXP3 IFNG IL10 IL2 IL6 NFKB1
11 neoplasm MP:0002006 9.73 CXCR3 IFNG IL10 IL2 IL6 MMP9
12 respiratory system MP:0005388 9.7 CXCR3 FOXP3 IFNG IL10 IL17A IL2
13 renal/urinary system MP:0005367 9.63 CXCR3 FOXP3 IFNG IL17A IL6 MMP9
14 vision/eye MP:0005391 9.17 FOXP3 IFNG IL10 IL2 IL2RA IL6

Drugs & Therapeutics for Tropical Spastic Paraparesis

Drugs for Tropical Spastic Paraparesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zidovudine Approved Phase 2, Phase 3,Early Phase 1 30516-87-1 35370
2
Lamivudine Approved, Investigational Phase 2, Phase 3 134678-17-4 60825
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4
Valproic Acid Approved, Investigational Phase 3,Not Applicable 99-66-1 3121
5
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
6 Reverse Transcriptase Inhibitors Phase 2, Phase 3,Early Phase 1
7 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Early Phase 1
8 Anti-HIV Agents Phase 2, Phase 3,Early Phase 1
9 Antiviral Agents Phase 2, Phase 3,Early Phase 1
10 Anti-Retroviral Agents Phase 2, Phase 3,Early Phase 1
11 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Early Phase 1
12 Antimetabolites Phase 2, Phase 3,Early Phase 1
13 Immunosuppressive Agents Phase 2, Phase 3
14 Calcineurin Inhibitors Phase 2, Phase 3
15 Antifungal Agents Phase 2, Phase 3
16 Immunologic Factors Phase 2, Phase 3
17 Dermatologic Agents Phase 2, Phase 3
18 Cyclosporins Phase 2, Phase 3
19 Antirheumatic Agents Phase 2, Phase 3
20 Psychotropic Drugs Phase 3,Not Applicable
21 GABA Agents Phase 3,Not Applicable
22 Central Nervous System Depressants Phase 3,Not Applicable
23 Antimanic Agents Phase 3,Not Applicable
24 Anticonvulsants Phase 3,Not Applicable
25 Tranquilizing Agents Phase 3,Not Applicable
26 Neurotransmitter Agents Phase 3,Not Applicable
27 Vasodilator Agents Phase 3
28 Phosphodiesterase Inhibitors Phase 3
29 Free Radical Scavengers Phase 3
30 Radiation-Protective Agents Phase 3
31 Protective Agents Phase 3
32 Platelet Aggregation Inhibitors Phase 3
33 Antioxidants Phase 3
34
Interferon beta-1a Approved, Investigational Phase 2 145258-61-3 6438354
35
Infliximab Approved Phase 2 170277-31-3
36 Interferon-beta Phase 2
37 interferons Phase 2
38 Adjuvants, Immunologic Phase 2
39 Gastrointestinal Agents Phase 2
40 Immunoglobulins Phase 1
41 Antibodies, Monoclonal Phase 1
42 Antibodies Phase 1
43 HIV Integrase Inhibitors Early Phase 1
44 Integrase Inhibitors Early Phase 1
45 Raltegravir Potassium Early Phase 1

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
2 Efficacy and Safety of Tamibarotene(AM80H) for HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Unknown status NCT01343355 Phase 2, Phase 3 Tamibarotene
3 Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial Completed NCT00272480 Phase 2, Phase 3 Zidovudine/lamivudine
4 Ciclosporin in HTLV-1 Associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) Completed NCT00773292 Phase 2, Phase 3 ciclosporin
5 Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) Completed NCT00681980 Phase 3 Valproic acid;costicosteroids;valproid acid plus corticosteroids
6 Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases Completed NCT01472263 Phase 3 Pentoxifylline;Placebo
7 A Study of KW-0761 in Subjects With HTLV-1 Associated Myelopathy (HAM) Active, not recruiting NCT03191526 Phase 3 KW-0761 0.3 mg/kg IV;Placebo (saline)
8 Recombinant Human Interferon Beta-1a (Avonex) for the Treatment of Patients With HTLV-1-Associated Myelopathy (HAM) Completed NCT00001785 Phase 2 Recombinant human interferon beta-1a
9 The HAM Infliximab Study Terminated NCT00823641 Phase 2 Infliximab
10 Immunotherapy of Natural Killer(NK) Cells in Human T Lymphotropic Virus Type 1(HTLV-1) Associated Myelopathy(HAM) Unknown status NCT02961712 Phase 1
11 Hu Mik-Beta-1 to Treat HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00076843 Phase 1 Hu MiK-Beta-1
12 Evaluation of the MP Diagnostics HTLV Blot 2.4 Unknown status NCT01467024
13 MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis Completed NCT00034723
14 A Study of Familial and Genetic Aspects of Adult T-Cell: Leukemia/Lymphoma , Tropical Spastic Paraparesis, and Infective Dermatitis Completed NCT00340821
15 Raltegravir for HAM/TSP Completed NCT01867320 Early Phase 1 Raltegravir
16 Urological Physical Therapy in HTLV-1 With Urinary Symptoms Completed NCT01651819 Not Applicable
17 Influence of IL28B Genetic Variation on the Phenotype Infection of HTLV-1 Completed NCT01754311
18 Assessment of Patients With Multiple Sclerosis (MS) Completed NCT00001156
19 Dual Algorithm Post Market Clinical Study Completed NCT03146013
20 Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection Recruiting NCT02655471 Early Phase 1 "Raltegravir" and "Zidovudine"
21 Evaluation of Patients With HAM/TSP Recruiting NCT00001778
22 Safety and Efficiency Study of Valproic Acid In HAM/TSP Terminated NCT00519181 Not Applicable Valproic Acid

Search NIH Clinical Center for Tropical Spastic Paraparesis

Cochrane evidence based reviews: paraparesis, tropical spastic

Genetic Tests for Tropical Spastic Paraparesis

Anatomical Context for Tropical Spastic Paraparesis

MalaCards organs/tissues related to Tropical Spastic Paraparesis:

41
T Cells, Spinal Cord, Skin, Lung, Eye, B Cells, Thyroid

Publications for Tropical Spastic Paraparesis

Articles related to Tropical Spastic Paraparesis:

(show top 50) (show all 434)
# Title Authors Year
1
Balance, functional mobility, and fall occurrence in patients with human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis: a cross-sectional study. ( 29768548 )
2018
2
Role of Integrin Signaling Activation on the Development of Human T-Cell Leukemia VIrus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis: Its Relationship to HTLV-1-infected CD4+ T Cell Transmigrating Activity into the Tissues. ( 29400072 )
2018
3
Temporal trends in Human T-Lymphotropic virus 1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) incidence in Martinique over 25 years (1986-2010). ( 29554087 )
2018
4
Early Juvenile HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP): Study of 25 Patients. ( 29912303 )
2018
5
Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 28965354 )
2018
6
Proposal of Classification Criteria for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Disease Activity. ( 30090093 )
2018
7
Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 30341468 )
2018
8
Interferon Lambda Family along with HTLV-1 Proviral Load, Tax, and HBZ Implicated in the Pathogenesis of Myelopathy/Tropical Spastic Paraparesis. ( 29990995 )
2018
9
Human T-Lymphotropic Virus-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Associated With Sexual Dysfunction in Infected Women of Reproductive Age. ( 30181035 )
2018
10
Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil. ( 30466392 )
2018
11
Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 28378248 )
2017
12
Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. ( 27894665 )
2017
13
Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study. ( 28536850 )
2017
14
Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 28420387 )
2017
15
Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. ( 28101786 )
2017
16
Clinical and laboratory features of HTLV-I asymptomatic carriers and patients with HTLV-I-associated myelopathy/tropical spastic paraparesis from the Brazilian Amazon. ( 28380116 )
2017
17
Indigenous tropical spastic paraparesis in Madrid (Spain). Experience on screening of human T-lymphotropic virus. ( 26282070 )
2017
18
Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. ( 29292042 )
2017
19
The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 29202792 )
2017
20
Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review. ( 28582585 )
2017
21
IL17A Polymorphism Is Not Associated with Human T-Lymphotropic Virus 1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28410448 )
2017
22
Cytoplasmic Localization of HTLV-1 HBZ Protein: A Biomarker of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). ( 28095504 )
2017
23
Mediators Go Together: High Production of CXCL9, CXCL10, IFN-γ, and TNF-α in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 28648091 )
2017
24
The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. ( 27845163 )
2017
25
Human T-Lymphotropic Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: The First Case Report in Southeast Asia. ( 28343405 )
2017
26
Correction: Familial Clusters of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 27028551 )
2016
27
Two Cases of Human T-Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis Caused by Living-Donor Renal Transplantation. ( 27777805 )
2016
28
HLA-G 3' untranslated region polymorphisms are associated with HTLV-1 infection, proviral load and HTLV-associated myelopathy/tropical spastic paraparesis development. ( 27449667 )
2016
29
Retrospective clinic and urodynamic study in the neurogenic bladder dysfunction caused by human T cell lymphotrophic virus type 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 26756420 )
2016
30
Clonus Associated with Tropical Spastic Paraparesis. ( 27783915 )
2016
31
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression. ( 27871430 )
2016
32
Electrophysiological Analysis Shows Dizziness as the First Symptom in Human T Cell Lymphotropic Virus Type-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25760424 )
2015
33
Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 25820278 )
2015
34
Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26156876 )
2015
35
High IFN-I^/IL-10 Expression Ratio and Increased Frequency of Persistent Human T-Cell Lymphotropic Virus Type 1-Infected Clones Are Associated with Human T-Cell Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis Development. ( 25833232 )
2015
36
Neurological manifestations in individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis in the Amazon. ( 26169165 )
2015
37
Common I^-chain blocking peptide reduces in vitro immune activation markers in HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26283355 )
2015
38
Neurological Manifestations in Human T-Cell Lymphotropic Virus Type 1 (HTLV-1)-Infected Individuals Without HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Longitudinal Cohort Study. ( 25820277 )
2015
39
Human T-lymphotropic virus 1 (HTLV-1)-associated lichenoid dermatitis induced by CD8(+) T cells in HTLV-1 carrier, HTLV-1-associated myelopathy/tropical spastic paraparesis and adult T-cell leukemia/lymphoma. ( 26077665 )
2015
40
Postrenal Transplant Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy/Tropical Spastic Paraparesis: A Case Report and Review of the Literature. ( 27500208 )
2015
41
HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 27188208 )
2015
42
Deep Sequencing Analysis of Human T Cell Lymphotropic Virus Type 1 Long Terminal Repeat 5' Region from Patients with Tropical Spastic Paraparesis/Human T Cell Lymphotropic Virus Type 1-Associated Myelopathy and Asymptomatic Carriers. ( 26472535 )
2015
43
Tax secretion from peripheral blood mononuclear cells and tax detection in plasma of patients with human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis and asymptomatic carriers. ( 26241614 )
2015
44
Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. ( 26174324 )
2015
45
HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL-28B Gene. ( 26609200 )
2015
46
Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 25884435 )
2015
47
Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 25470342 )
2015
48
A Peruvian family with a high burden of HTLV-1-associated myelopathy/tropical spastic paraparesis. ( 26392440 )
2015
49
Immunopathogenesis of HTLV-1-assoaciated myelopathy/tropical spastic paraparesis (HAM/TSP). ( 24704970 )
2014
50
Interferon beta-1a treatment in HTLV-1-associated myelopathy/tropical spastic paraparesis: a case report. ( 25229227 )
2014

Variations for Tropical Spastic Paraparesis

Expression for Tropical Spastic Paraparesis

Search GEO for disease gene expression data for Tropical Spastic Paraparesis.

Pathways for Tropical Spastic Paraparesis

Pathways related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CCL5 HLA-B IFNG IFNL3 IL10 IL17A
2
Show member pathways
13.85 CCL5 CXCR3 IL10 IL17A IL2 IL2RA
3
Show member pathways
13.59 CCL5 CXCR3 IFNG IFNL3 IL10 IL17A
4
Show member pathways
13.55 CCL5 IFNG IL10 IL17A IL2 IL2RA
5
Show member pathways
13.4 CCL5 CXCR3 IL10 IL17A IL2 IL2RA
6
Show member pathways
13.26 CCL5 CXCR3 IL10 IL17A IL2 IL2RA
7
Show member pathways
13.04 CCL5 HLA-B IFNG IFNL3 IL10 IL17A
8
Show member pathways
13.03 CCL5 HLA-B IL6 MMP9 NFKB1
9
Show member pathways
13.03 CCL5 IFNG IL10 IL2 IL6 NFKB1
10
Show member pathways
12.98 HLA-B IL2 IL2RA IL6 NFKB1
11 12.87 IFNG IL2 IL2RA IL6 MMP9 NFKB1
12
Show member pathways
12.83 FOXP3 HLA-B IFNG IL10 IL17A IL2
13
Show member pathways
12.79 CCL5 IFNG IFNL3 IL6 NFKB1
14
Show member pathways
12.79 CCL5 HLA-B IFNG IL2 IL2RA IL6
15
Show member pathways
12.66 IFNG IL10 IL2 IL2RA NFKB1
16
Show member pathways
12.61 IFNG IL10 IL17A IL2 IL6 NFKB1
17
Show member pathways
12.54 FOXP3 IFNG IL10 IL17A IL2 IL2RA
18 12.47 HLA-B IL2 IL2RA IL6 NFKB1
19
Show member pathways
12.43 IFNG IFNL3 IL10 IL2 IL2RA IL6
20
Show member pathways
12.43 IFNG IL10 IL17A IL2 IL6 NFKB1
21
Show member pathways
12.38 CCL5 IFNG IL2 IL6 NFKB1
22
Show member pathways
12.37 IFNG IL17A IL6 MMP9 NFKB1
23 12.27 IFNG IL10 IL6 NFKB1
24
Show member pathways
12.25 IL10 IL2 IL6 NFKB1
25 12.23 IFNG IL6 MMP9 NFKB1
26
Show member pathways
12.23 HLA-B IFNG IL10 IL17A IL2 IL2RA
27 12.12 CCL5 FOXP3 IFNG IL10 IL17A IL2
28
Show member pathways
12.1 IFNG IL10 IL17A IL2 IL6
29 12.07 IFNG MMP9 NFKB1
30 12.07 IFNG IL2 IL6 MMP9
31
Show member pathways
12.05 IFNG IL2 IL2RA
32
Show member pathways
12.05 CCL5 IFNG IL10 IL17A IL2 IL2RA
33 12.04 IL10 IL17A IL6 MMP9
34
Show member pathways
12.04 IFNG IL2 IL2RA NFKB1
35 12.03 IFNG IL10 IL2 IL2RA IL6
36
Show member pathways
12.02 IFNG IL6 MMP9
37 12.02 CCL5 IL6 MMP9 NFKB1
38
Show member pathways
12.01 IL2 IL2RA NFKB1
39
Show member pathways
11.95 IL2 IL2RA NFKB1
40 11.95 IFNG IL10 IL6 NFKB1
41
Show member pathways
11.93 FOXP3 IL17A IL6 NFKB1
42 11.92 IFNG IL10 IL2 IL2RA IL6
43 11.91 IFNG IL6 NFKB1
44 11.91 CCL5 IFNG IL17A IL6
45 11.87 IFNG IL2 IL6 NFKB1
46 11.85 IFNG IL6 NFKB1
47
Show member pathways
11.82 FOXP3 IFNG IL2 IL2RA
48 11.8 IFNG IL10 IL2 IL6
49 11.79 IL10 IL6 NFKB1
50
Show member pathways
11.75 FOXP3 IL2 IL2RA NFKB1

GO Terms for Tropical Spastic Paraparesis

Cellular components related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.56 CXCR3 IL17A IL2RA TNFRSF4
2 extracellular space GO:0005615 9.56 CCL5 IFNG IFNL3 IL10 IL17A IL2
3 cell surface GO:0009986 9.55 CNTN2 CXCR3 HLA-B IL2RA TNFRSF4
4 extracellular region GO:0005576 9.28 CCL5 IFNG IFNL3 IL10 IL17A IL2

Biological processes related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 IL10 IL2 IL6 MMP9 NFKB1
2 regulation of signaling receptor activity GO:0010469 9.87 CCL5 IFNG IFNL3 IL10 IL17A IL2
3 response to virus GO:0009615 9.8 CCL5 FOXP3 IFNG
4 inflammatory response GO:0006954 9.8 CCL5 CXCR3 IL10 IL17A IL6 NFKB1
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.78 CCL5 IFNG IL2 IL6
6 negative regulation of inflammatory response GO:0050728 9.77 FOXP3 IL10 IL2 IL2RA NFKB1
7 cellular response to interleukin-1 GO:0071347 9.73 CCL5 IL17A NFKB1
8 positive regulation of T cell proliferation GO:0042102 9.73 CCL5 IL2 IL2RA IL6
9 negative regulation of T cell proliferation GO:0042130 9.69 FOXP3 IL10 IL2RA
10 positive regulation of osteoclast differentiation GO:0045672 9.63 IFNG IL17A
11 positive regulation of T cell differentiation GO:0045582 9.63 IL2 IL2RA
12 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL2 IL6 TNFRSF4
13 negative regulation of immune response GO:0050777 9.61 FOXP3 IL2RA
14 negative regulation of cytokine secretion GO:0050710 9.61 FOXP3 TNFRSF4
15 negative regulation of interleukin-17 production GO:0032700 9.59 FOXP3 IFNG
16 positive regulation of regulatory T cell differentiation GO:0045591 9.58 FOXP3 IL2
17 interleukin-2-mediated signaling pathway GO:0038110 9.58 IL2 IL2RA
18 negative regulation of lymphocyte proliferation GO:0050672 9.58 FOXP3 IL2 IL2RA
19 cytokine-mediated signaling pathway GO:0019221 9.56 CCL5 IFNL3 IL10 IL17A IL2 IL2RA
20 negative regulation of T-helper 17 cell differentiation GO:2000320 9.55 FOXP3 IL2
21 positive regulation of interleukin-23 production GO:0032747 9.54 IFNG IL17A
22 regulation of T cell anergy GO:0002667 9.52 FOXP3 HLA-B
23 regulation of T cell homeostatic proliferation GO:0046013 9.49 IL2 IL2RA
24 regulation of regulatory T cell differentiation GO:0045589 9.46 FOXP3 IFNG IL2 IL2RA
25 immune response GO:0006955 9.32 CCL5 CXCR3 HLA-B IFNG IL10 IL17A
26 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 FOXP3 IL10 IL17A IL2 IL6 NFKB1
27 apoptotic process GO:0006915 10.02 CXCR3 IFNG IL17A IL2RA NFKB1

Molecular functions related to Tropical Spastic Paraparesis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL5 IFNG IFNL3 IL10 IL17A IL2

Sources for Tropical Spastic Paraparesis

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