MCID: TRP004
MIFTS: 36

Tropical Sprue

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Tropical Sprue

MalaCards integrated aliases for Tropical Sprue:

Name: Tropical Sprue 12 77 54 15
Sprue, Tropical 45 74
Idiopathic Tropical Malabsorption Syndrome 54
Tropical Steatorrhea 12
Tropical Enteropathy 54
Sprue - Tropical 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10607
ICD9CM 36 579.1
MeSH 45 D013182
NCIt 51 C45428
SNOMED-CT 69 47384003
ICD10 34 K90.1
UMLS 74 C0038054

Summaries for Tropical Sprue

MalaCards based summary : Tropical Sprue, also known as sprue, tropical, is related to whipple disease and celiac disease 1. An important gene associated with Tropical Sprue is GGH (Gamma-Glutamyl Hydrolase). The drugs Glycine and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pancreas.

Wikipedia : 77 Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal... more...

Related Diseases for Tropical Sprue

Diseases related to Tropical Sprue via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 whipple disease 11.5
2 celiac disease 1 10.4
3 diarrhea 10.3
4 steatorrhea 10.2
5 pernicious anemia 10.2
6 macrocytic anemia 10.2
7 blind loop syndrome 10.1
8 megaloblastic anemia 10.1
9 gastroenteritis 10.1
10 lymphoma 10.0
11 ichthyosis bullosa of siemens 9.9
12 intussusception 9.9
13 hypokalemic periodic paralysis, type 1 9.9
14 myeloma, multiple 9.9
15 aging 9.9
16 malaria 9.9
17 exocrine pancreatic insufficiency 9.9
18 neutropenia 9.9
19 thrombocytopenia 9.9
20 vitamin b12 deficiency 9.9
21 colitis 9.9
22 microscopic colitis 9.9
23 megacolon 9.9
24 agammaglobulinemia 9.9
25 duodenogastric reflux 9.7 PYY SCT
26 dumping syndrome 9.6 PYY SCT
27 pancreas disease 9.5 ALB SCT
28 gastrointestinal system disease 9.4 ALB PYY SCT

Comorbidity relations with Tropical Sprue via Phenotypic Disease Network (PDN):


Celiac Disease 1 Deficiency Anemia
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Tropical Sprue:



Diseases related to Tropical Sprue

Symptoms & Phenotypes for Tropical Sprue

Drugs & Therapeutics for Tropical Sprue

Drugs for Tropical Sprue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 3 56-40-6 750
2 Immunologic Factors Phase 3,Phase 1
3 Vaccines Phase 3,Phase 1
4 Neurotransmitter Agents Phase 3
5 glutamine Phase 3
6 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
7 Antirheumatic Agents Phase 1, Phase 2
8 Anti-Inflammatory Agents Phase 1, Phase 2
9 Peripheral Nervous System Agents Phase 1, Phase 2
10 Analgesics Phase 1, Phase 2
11 Analgesics, Non-Narcotic Phase 1, Phase 2
12 Mesalamine Phase 1, Phase 2 89-57-6
13
Rifaximin Approved, Investigational Not Applicable 80621-81-4 46783403 6436173
14
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
15 Gastrointestinal Agents Not Applicable
16 Antibiotics, Antitubercular Not Applicable
17 Anti-Infective Agents Not Applicable
18 Anti-Bacterial Agents Not Applicable
19 Immunoglobulins Not Applicable
20 Trace Elements Not Applicable
21 Nutrients Not Applicable
22 Vitamins Not Applicable
23 retinol Not Applicable
24 Retinol palmitate Not Applicable
25 Micronutrients Not Applicable
26 Antibodies Not Applicable
27 Disinfectants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh Completed NCT01375647 Phase 3
2 Intervention and Mechanisms of Alanyl-Glutamine for Inflammation, Nutrition, and Enteropathy Completed NCT01832636 Phase 3
3 Mesalamine in Environmental Enteropathy Completed NCT01841099 Phase 1, Phase 2 Mesalamine;Placebo granules
4 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in INDIA (PROVIDE) Completed NCT01571505 Phase 1
5 Trial of Rifaximin in the Treatment of Tropical Enteropathy Completed NCT00858988 Not Applicable Rifaximin
6 Plasma Citrulline Concentration in Tropical Enteropathy Completed NCT00816842
7 WASH Benefits Kenya Completed NCT01704105 Not Applicable
8 Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa Active, not recruiting NCT03012048 Not Applicable
9 WASH Benefits Bangladesh Active, not recruiting NCT01590095 Not Applicable

Search NIH Clinical Center for Tropical Sprue

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: sprue, tropical

Genetic Tests for Tropical Sprue

Anatomical Context for Tropical Sprue

MalaCards organs/tissues related to Tropical Sprue:

42
Small Intestine, Testes, Pancreas, Colon, Whole Blood, Adrenal Gland

Publications for Tropical Sprue

Articles related to Tropical Sprue:

(show top 50) (show all 366)
# Title Authors Year
1
Clinical, endoscopic, and histological differentiation between celiac disease and tropical sprue: A systematic review. ( 30069926 )
2019
2
Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link. ( 28513629 )
2017
3
Infectious Gastroenteritis as a Risk Factor for Tropical Sprue and Malabsorption: A Case-Control Study. ( 26115751 )
2015
4
Tropical sprue: revisiting an underrecognized disease. ( 24441659 )
2014
5
Tropical sprue in 2014: the new face of an old disease. ( 24781741 )
2014
6
Distinguishing tropical sprue from celiac disease in returning travellers with chronic diarrhoea: a diagnostic challenge? ( 24889052 )
2014
7
Tropical sprue: a riddle wrapped in a mystery inside an enigma. ( 23481048 )
2013
8
Pathogenesis of tropical sprue: a pilot study of antroduodenal manometry, duodenocaecal transit time & fat-induced ileal brake. ( 23481053 )
2013
9
Tropical sprue: two cases report and review of literature. Has anything changed in the past 40 years? ( 23590053 )
2013
10
A presentation of latent tropical sprue in a Canadian hospital. ( 23636074 )
2013
11
Is the ghost of tropical sprue re-surfacing after its obituary? ( 22315742 )
2011
12
Spectrum of malabsorption in India--tropical sprue is still the leader. ( 22315745 )
2011
13
Abnormal small intestinal permeability in patients with idiopathic malabsorption in tropics (tropical sprue) does not change even after successful treatment. ( 20411417 )
2011
14
The Face of Tropical Sprue in 2010. ( 20805939 )
2010
15
Classification of villous atrophy with enhanced magnification endoscopy in patients with celiac disease and tropical sprue. ( 17643717 )
2007
16
Tropical sprue in two foreign residents, with evidence of Tropheryma whippelii in one case. ( 16706950 )
2006
17
Tropical sprue in Far North Queensland. ( 15896184 )
2005
18
Tropical sprue. ( 16168231 )
2005
19
Tropical Sprue. ( 14723833 )
2004
20
Tropical sprue: revisited. ( 15129872 )
2004
21
Images of interest. Gastrointestinal: tropical sprue. ( 15304129 )
2004
22
Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time. ( 12702046 )
2003
23
What is tropical sprue? ( 12859716 )
2003
24
Exocrine pancreatic insufficiency in tropical sprue. ( 11173897 )
2001
25
William Twining (1790-1835): the first accurate clinical descriptions of "tropical sprue" and kala-azar? ( 11466511 )
2001
26
A perspective on tropical sprue. ( 11470001 )
2001
27
Tropical sprue in north Indian children. ( 11681110 )
2001
28
Treatment of tropical sprue: the work of Dr. Bailey K. Ashford examined in retrospect. ( 11776723 )
2001
29
Tropical sprue after travel to Tanzania. ( 10689238 )
2000
30
Tropical sprue as a cause of traveler's diarrhea. ( 10921367 )
2000
31
Tropical sprue and subclinical enteropathy: a vision for the nineties. ( 9288443 )
1997
32
Association of lymphocytic (microscopic) colitis with tropical sprue. ( 8155860 )
1994
33
Hypokalemic periodic paralysis in association with tropical sprue: a case report. ( 7887139 )
1994
34
Quantitation of immunoglobulin-containing cells in the jejunal lamina propria in tropical sprue. ( 1556433 )
1992
35
Case records of the Massachusetts General Hospital weekly clinicopathological exercises. Case 29-1992. A 76-year-old woman with recurrent diarrhea several months after treatment for tropical sprue. ( 1608409 )
1992
36
Scalloping of the valvulae conniventes and mosaic mucosa in tropical sprue. ( 2070991 )
1991
37
Tropical sprue. ( 2205942 )
1990
38
Vincent Ketelaer did not describe tropical or non-tropical sprue or coeliac disease in his book De Aphthis Nostratibus seu Belgarum Sprouw. ( 2278120 )
1990
39
Jejunal surface pH measurements in tropical sprue. ( 2603196 )
1989
40
Intestinal transit in healthy southern Indian subjects and in patients with tropical sprue. ( 2920924 )
1989
41
Absorption of water and sodium and activity of adenosine triphosphatases in the rectal mucosa in tropical sprue. ( 2840363 )
1988
42
Tropical sprue in southern India. ( 3051540 )
1988
43
Role of bacterial toxins, bile acids, and free fatty acids in colonic water malabsorption in tropical sprue. ( 3568936 )
1987
44
HLA and tropical sprue. ( 2877326 )
1986
45
Tropical sprue and multiple myeloma. ( 3462885 )
1986
46
Tropical sprue--its aetiology and pathogenesis. ( 3537290 )
1986
47
Tropical sprue--a clinical, biochemical and histopathological study. ( 3564147 )
1986
48
Epithelial cell renewal and turnover and relationship to morphologic abnormalities in jejunal mucosa in tropical sprue. ( 3709324 )
1986
49
Intestinal absorption and unmediated permeation of sugars in post-infective tropical malabsorption (tropical sprue). ( 3949090 )
1986
50
Tropical sprue in visitor to Mexico. ( 2857825 )
1985

Variations for Tropical Sprue

Expression for Tropical Sprue

Search GEO for disease gene expression data for Tropical Sprue.

Pathways for Tropical Sprue

GO Terms for Tropical Sprue

Cellular components related to Tropical Sprue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 ALB GGH PYY SCT
2 extracellular space GO:0005615 8.92 ALB GGH PYY SCT

Biological processes related to Tropical Sprue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 8.8 CD3E PYY SCT

Molecular functions related to Tropical Sprue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 PYY SCT
2 G protein-coupled receptor binding GO:0001664 8.62 PYY SCT

Sources for Tropical Sprue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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