MCID: TRP004
MIFTS: 41

Tropical Sprue

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Tropical Sprue

MalaCards integrated aliases for Tropical Sprue:

Name: Tropical Sprue 12 75 53 15 33
Sprue, Tropical 44 72
Idiopathic Tropical Malabsorption Syndrome 53
Tropical Steatorrhea 12
Tropical Enteropathy 53
Sprue - Tropical 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10607
ICD9CM 35 579.1
MeSH 44 D013182
NCIt 50 C45428
SNOMED-CT 68 47384003
ICD10 33 K90.1
UMLS 72 C0038054

Summaries for Tropical Sprue

MalaCards based summary : Tropical Sprue, also known as sprue, tropical, is related to diarrhea and irritable bowel syndrome. An important gene associated with Tropical Sprue is GGH (Gamma-Glutamyl Hydrolase), and among its related pathways/superpathways are Peptide ligand-binding receptors and G alpha (s) signalling events. The drugs Glycine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver, and related phenotypes are no effect and immune system

Wikipedia : 75 Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal... more...

Related Diseases for Tropical Sprue

Diseases related to Tropical Sprue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 diarrhea 30.9 SST GAST ALB
2 irritable bowel syndrome 30.4 VIP PYY MLN
3 blind loop syndrome 30.2 MLN CBLIF ALB
4 pernicious anemia 30.0 SST GAST CBLIF
5 zollinger-ellison syndrome 29.6 SST SCT NTS GAST
6 constipation 28.4 VIP SST PYY NTS MLN GAST
7 gastrointestinal system disease 27.5 SST SCT PYY MLN GCG GAST
8 whipple disease 11.7
9 non-secretory myeloma 10.5 ITGAE ALB
10 celiac disease 1 10.5
11 yellow nail syndrome 10.5 SST ALB
12 steatorrhea 10.5
13 wdha syndrome 10.5 VIP SST
14 chylothorax, congenital 10.4 SST ALB
15 angiodysplasia 10.4 SST SCT
16 somatostatinoma 10.4 VIP SST
17 overgrowth syndrome 10.4
18 adie pupil 10.4 VIP TNFRSF25
19 pancreatoblastoma 10.4 SST NTS
20 megaloblastic anemia 10.4
21 esophageal varix 10.4 SST ALB
22 ascending cholangitis 10.4 TNFRSF25 ALB
23 deficiency anemia 10.3
24 macrocytic anemia 10.3
25 ostertagiasis 10.3 GAST ALB
26 pancreatic somatostatinoma 10.3 SST PPY
27 trichostrongyloidiasis 10.3 GAST ALB
28 glucagonoma 10.3 VIP SST SCT
29 carcinoid syndrome 10.3 SST PYY NTS
30 duodenal somatostatinoma 10.3 SST PPY
31 small intestine lymphoma 10.3 ITGAE CD3E CBLIF
32 pancreatic steatorrhea 10.2 SCT CBLIF
33 gastroenteritis 10.2
34 vitamin b12 deficiency 10.2
35 binswanger's disease 10.1 VIP SST
36 granulomatous gastritis 10.1 GAST CBLIF
37 osteomalacia 10.1
38 giardiasis 10.1
39 liver cirrhosis 10.1
40 intestinal disease 10.1
41 postgastrectomy syndrome 10.0 VIP SST PYY NTS
42 fetal erythroblastosis 10.0 PPY ALB
43 insulinomatosis and diabetes mellitus 10.0 SST SCT GAST
44 functional colonic disease 10.0 SST MLN
45 serotonin syndrome 10.0 SST PYY GAST
46 diphyllobothriasis 9.9 SCT GAST CBLIF
47 intussusception 9.9
48 hypokalemic periodic paralysis, type 1 9.9
49 myeloma, multiple 9.9
50 beta-thalassemia 9.9

Comorbidity relations with Tropical Sprue via Phenotypic Disease Network (PDN):


Celiac Disease 1 Deficiency Anemia
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Tropical Sprue:



Diseases related to Tropical Sprue

Symptoms & Phenotypes for Tropical Sprue

GenomeRNAi Phenotypes related to Tropical Sprue according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.9 ALB CBLIF CD3E GAST GCG GGH

MGI Mouse Phenotypes related to Tropical Sprue:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 CBLIF CD3E GAST ITGAE SIX1 SST

Drugs & Therapeutics for Tropical Sprue

Drugs for Tropical Sprue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 3 56-40-6 750
2 Vaccines Phase 3
3 Immunologic Factors Phase 3
4 Neurotransmitter Agents Phase 3
5 glutamine Phase 3
6 Analgesics Phase 1, Phase 2
7 Analgesics, Non-Narcotic Phase 1, Phase 2
8 Mesalamine Phase 1, Phase 2 89-57-6
9 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
10 Peripheral Nervous System Agents Phase 1, Phase 2
11 Anti-Inflammatory Agents Phase 1, Phase 2
12 Antirheumatic Agents Phase 1, Phase 2
13
Rifaximin Approved, Investigational 80621-81-4 46783403 6436173
14
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
15 Gastrointestinal Agents
16 Anti-Bacterial Agents
17 Antibiotics, Antitubercular
18 Anti-Infective Agents
19 Disinfectants
20 Vitamins
21 Antibodies
22 retinol
23 Nutrients
24 Retinol palmitate
25 Micronutrients
26 Trace Elements
27 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh Completed NCT01375647 Phase 3
2 Intervention and Mechanisms of Alanyl-Glutamine for Inflammation, Nutrition, and Enteropathy (IMAGINE) Completed NCT01832636 Phase 3
3 Randomised Placebo-controlled Trial of a Gut Immunomodulatory Agent (Mesalamine) to Tackle Environmental Enteropathy in Acutely Malnourished Children: A Pilot Study. Completed NCT01841099 Phase 1, Phase 2 Mesalamine;Placebo granules
4 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in INDIA Completed NCT01571505 Phase 1
5 A Randomized, Double-Blind, Placebo-Controlled Trial of Rifaximin, a Non-Absorbable Antibiotic, in the Treatment of Tropical Enteropathy Completed NCT00858988 Rifaximin
6 Plasma Citrulline as Quantitative Biomarker of HIV Associate Villous Atrophy in a Tropical Enteropathy Population Completed NCT00816842
7 WASH Benefits Kenya: A Cluster Randomized Controlled Trial of the Benefits of Sanitation, Water Quality, Handwashing, and Nutrition Interventions on Child Health and Development Completed NCT01704105
8 Effectiveness of Low-cost Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in Limpopo, South Africa Active, not recruiting NCT03012048
9 WASH Benefits Bangladesh: A Cluster Randomized Controlled Trial of the Benefits of Water, Sanitation, Hygiene Plus Nutrition Interventions on Child Growth Active, not recruiting NCT01590095

Search NIH Clinical Center for Tropical Sprue

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Medium chain triglycerides

Cochrane evidence based reviews: sprue, tropical

Genetic Tests for Tropical Sprue

Anatomical Context for Tropical Sprue

MalaCards organs/tissues related to Tropical Sprue:

41
Small Intestine, Testes, Liver, Pancreas, Colon, Adrenal Gland, Whole Blood

Publications for Tropical Sprue

Articles related to Tropical Sprue:

(show top 50) (show all 541)
# Title Authors PMID Year
1
Synthesis and characterization of Abhraka (mica) bhasma by two different methods. 38
30826258 2019
2
Clinical, endoscopic, and histological differentiation between celiac disease and tropical sprue: A systematic review. 38
30069926 2019
3
[Tropical sprue: report of a case]. 38
30317744 2018
4
Immunohistochemical Expression of Antitissue Transglutaminase 2 in Tissue Injuries: An Interpretation Beyond Celiac Disease. 38
27753658 2018
5
Practical Approach to the Flattened Duodenal Biopsy. 38
29103535 2017
6
Epidemiological and clinical perspectives on irritable bowel syndrome in India, Bangladesh and Malaysia: A review. 38
29085223 2017
7
Pros and Cons While Looking Through an Asian Window on the Rome IV Criteria for Irritable Bowel Syndrome: Pros. 38
28672432 2017
8
Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link. 38
28513629 2017
9
Prevalence and Characteristics of Duodenal Villous Atrophy in Renal Transplant Patients Presenting With Persistent Diarrhea in a Developing Country. 38
26496241 2016
10
Olmesartan-associated sprue-like enteropathy: a systematic review with emphasis on histopathology. 38
26997446 2016
11
The maladies of malabsorption. 38
27195041 2016
12
Spectrum of chronic small bowel diarrhea with malabsorption in Indian subcontinent: is the trend really changing? 38
26884738 2016
13
Disorders associated with malabsorption of iron: A critical review. 38
26870134 2015
14
Infectious Gastroenteritis as a Risk Factor for Tropical Sprue and Malabsorption: A Case-Control Study. 38
26115751 2015
15
Early, non-refractory celiac disease associated with microscopic colitis and splenomegaly. 38
25933449 2015
16
Gastrointestinal complications in renal transplant recipients detected by endoscopic biopsies in a developing country. 38
25757628 2015
17
The biopsy pathology of non-coeliac enteropathy. 38
25234408 2015
18
Neil Hamilton Fairley KBE FRCP FRS (1891-1966): an outstanding tropical physician in the twentieth century. 38
24833541 2014
19
Distinguishing tropical sprue from celiac disease in returning travellers with chronic diarrhoea: a diagnostic challenge? 38
24889052 2014
20
Tropical sprue: revisiting an underrecognized disease. 38
24441659 2014
21
Neurologic manifestations of malabsorption syndromes. 38
24365342 2014
22
Tropical sprue in 2014: the new face of an old disease. 38
24781741 2014
23
[Tropical sprue as a differential diagnosis to coeliac disease in a patient on immunosuppressive medication]. 38
24629612 2014
24
Clinical utility of retrograde terminal ileum intubation in the evaluation of chronic non-bloody diarrhea. 38
23777610 2013
25
Pathology of celiac disease: a brief review. 38
25046883 2013
26
The clinical significance of duodenal lymphocytosis with normal villus architecture. 38
23991733 2013
27
A presentation of latent tropical sprue in a Canadian hospital. 38
23636074 2013
28
Tropical sprue: two cases report and review of literature. Has anything changed in the past 40 years? 38
23590053 2013
29
Pathogenesis of tropical sprue: a pilot study of antroduodenal manometry, duodenocaecal transit time & fat-induced ileal brake. 38
23481053 2013
30
Tropical sprue: a riddle wrapped in a mystery inside an enigma. 38
23481048 2013
31
Diarrhoea due to small bowel diseases. 38
23384804 2012
32
[Tropical sprue in an expatriate]. 38
22405324 2012
33
Spectrum of malabsorption in India--tropical sprue is still the leader. 38
22315745 2011
34
Is the ghost of tropical sprue re-surfacing after its obituary? 38
22315742 2011
35
Post-infectious irritable bowel syndrome: the past, the present and the future. 38
21443719 2011
36
Current spectrum of malabsorption syndrome in adults in India. 38
21369836 2011
37
Abnormal small intestinal permeability in patients with idiopathic malabsorption in tropics (tropical sprue) does not change even after successful treatment. 38
20411417 2011
38
The Face of Tropical Sprue in 2010. 38
20805939 2010
39
[Tropical sprue: an unusual differential diagnosis in chronic diarrhea]. 38
19572249 2009
40
Classification of villous atrophy with enhanced magnification endoscopy in patients with celiac disease and tropical sprue. 38
17643717 2007
41
[Tropical sprue]. 38
17336033 2007
42
Diagnostic value of endoscopy for the diagnosis of giardiasis and other intestinal diseases in patients with persistent diarrhea from tropical or subtropical areas. 38
17354120 2007
43
The pathology of malabsorption: current concepts. 38
17204022 2007
44
Tropical malabsorption. 38
17148698 2006
45
Tropical sprue in two foreign residents, with evidence of Tropheryma whippelii in one case. 38
16706950 2006
46
Monitoring nonresponsive patients who have celiac disease. 38
16644460 2006
47
Profile of chronic small-bowel diarrhea in adults in Western India: a hospital-based study. 38
17089618 2006
48
Malabsorption syndrome due to various causes is associated with antroduodenal hypomotility. 38
16763331 2006
49
Tropical sprue. 38
16168231 2005
50
[Tropical or non-tropical sprue?]. 38
16261708 2005

Variations for Tropical Sprue

Expression for Tropical Sprue

Search GEO for disease gene expression data for Tropical Sprue.

Pathways for Tropical Sprue

GO Terms for Tropical Sprue

Cellular components related to Tropical Sprue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 SST SCT PYY PPY GRP GGH
2 extracellular region GO:0005576 9.47 VIP TNFRSF25 SST SCT PYY PPY

Biological processes related to Tropical Sprue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.36 VIP SST SCT PYY PPY NTS
2 neuropeptide signaling pathway GO:0007218 9.13 PYY PPY GRP

Molecular functions related to Tropical Sprue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.35 VIP PYY PPY NTS GRP
2 G protein-coupled receptor binding GO:0001664 9.33 SCT PYY PPY
3 hormone activity GO:0005179 9.23 VIP SST SCT PYY PPY MLN

Sources for Tropical Sprue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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