MCID: TRP004
MIFTS: 41

Tropical Sprue

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Tropical Sprue

MalaCards integrated aliases for Tropical Sprue:

Name: Tropical Sprue 12 74 52 15 32
Sprue, Tropical 43 71
Idiopathic Tropical Malabsorption Syndrome 52
Tropical Steatorrhea 12
Tropical Enteropathy 52
Sprue - Tropical 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10607
ICD9CM 34 579.1
MeSH 43 D013182
NCIt 49 C45428
SNOMED-CT 67 47384003
ICD10 32 K90.1
UMLS 71 C0038054

Summaries for Tropical Sprue

MalaCards based summary : Tropical Sprue, also known as sprue, tropical, is related to macrocytic anemia and diarrhea. An important gene associated with Tropical Sprue is TOR1A (Torsin Family 1 Member A), and among its related pathways/superpathways are Metabolism of water-soluble vitamins and cofactors and Folate Metabolism. The drugs Glycine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver.

Wikipedia : 74 Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal... more...

Related Diseases for Tropical Sprue

Diseases related to Tropical Sprue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 macrocytic anemia 30.4 GAST CBLIF AMN
2 diarrhea 30.4 TGM2 PYY LCT GAST ALB
3 megaloblastic anemia 30.0 TCN1 SLC46A1 CBLIF AMN
4 glossitis 29.3 CBLIF ATP4A ATP12A
5 blind loop syndrome 29.2 CBLIF ATP4A ATP12A ALB
6 microscopic colitis 29.0 TOR1A TGM2 ATP4A ATP12A
7 zollinger-ellison syndrome 29.0 GAST ATP4A ATP12A
8 deficiency anemia 28.9 SLC46A1 CBLIF ATP4A ATP12A ALB
9 giardiasis 28.6 TOR1A TGM2 LCT ATP4A ATP12A ALB
10 pernicious anemia 28.5 TCN1 GAST CBLIF ATP4A ATP12A
11 peptic esophagitis 28.3 LCT GAST ATP4A ATP12A ALB
12 vitamin b12 deficiency 28.1 TCN1 GAST CBLIF ATP4A ATP12A AMN
13 constipation 28.0 TGM2 PYY GAST ATP4A ATP12A ALB
14 celiac disease 1 28.0 TOR1A TGM2 PYY LCT GAST CBLIF
15 whipple disease 11.5
16 overgrowth syndrome 10.4
17 gluten allergy 10.4 TOR1A TGM2
18 immunoglobulin a deficiency 1 10.3 TOR1A TGM2
19 wheat allergy 10.3 TOR1A TGM2
20 torsion dystonia 2 10.3 TOR1A TGM2
21 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.3
22 angular cheilitis 10.3 CBLIF ALB
23 folic acid deficiency anemia 10.3 SLC46A1 CBLIF
24 jejunoileitis 10.3 TOR1A TGM2 ALB
25 gastroenteritis 10.2
26 gastrointestinal neuroendocrine benign tumor 10.2 GAST CBLIF
27 gastric neuroendocrine neoplasm 10.2 GAST CBLIF
28 irritable bowel syndrome 10.2
29 dystonia 25 10.2 TOR1A TGM2
30 congenital intrinsic factor deficiency 10.1 CBLIF AMN ALB
31 transcobalamin ii deficiency 10.1 TCN1 CBLIF
32 osteomalacia 10.1
33 liver cirrhosis 10.1
34 intestinal disease 10.1
35 endometrial small cell carcinoma 10.1 PYY GAST
36 3-methylglutaconic aciduria, type i 10.0 TCN1 CBLIF AMN
37 intussusception 9.9
38 hypokalemic periodic paralysis, type 1 9.9
39 myeloma, multiple 9.9
40 beta-thalassemia 9.9
41 lymphoma 9.9
42 alpha chain disease 9.9
43 colitis 9.9
44 thalassemia 9.9
45 bacterial infectious disease 9.9
46 protein-losing enteropathy 9.9
47 megacolon 9.9
48 esophagitis 9.9
49 neutropenia 9.9
50 shigellosis 9.9

Comorbidity relations with Tropical Sprue via Phenotypic Disease Network (PDN):


Celiac Disease 1 Deficiency Anemia
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Tropical Sprue:



Diseases related to Tropical Sprue

Symptoms & Phenotypes for Tropical Sprue

Drugs & Therapeutics for Tropical Sprue

Drugs for Tropical Sprue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 3 56-40-6 750
2 Vaccines Phase 3
3 glutamine Phase 3
4 Analgesics, Non-Narcotic Phase 1, Phase 2
5 Mesalamine Phase 1, Phase 2 89-57-6
6 Analgesics Phase 1, Phase 2
7 Anti-Inflammatory Agents Phase 1, Phase 2
8 Antirheumatic Agents Phase 1, Phase 2
9 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
10 Immunologic Factors Phase 1
11
Rifaximin Approved, Investigational 80621-81-4 6436173 46783403
12
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
13 Anti-Bacterial Agents
14 Gastrointestinal Agents
15 Antibiotics, Antitubercular
16 Anti-Infective Agents
17 Trace Elements
18 Immunoglobulins
19 Vitamins
20 Antibodies
21 Retinol palmitate
22 retinol
23 Nutrients
24 Micronutrients

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh Completed NCT01375647 Phase 3
2 Intervention and Mechanisms of Alanyl-Glutamine for Inflammation, Nutrition, and Enteropathy (IMAGINE) Completed NCT01832636 Phase 3
3 Randomised Placebo-controlled Trial of a Gut Immunomodulatory Agent (Mesalamine) to Tackle Environmental Enteropathy in Acutely Malnourished Children: A Pilot Study. Completed NCT01841099 Phase 1, Phase 2 Mesalamine;Placebo granules
4 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in INDIA Completed NCT01571505 Phase 1
5 A Randomized, Double-blind, Placebo-controlled Trial of Rifaximin, a Non-absorbable Antibiotic, in the Treatment of Tropical Enteropathy Completed NCT00858988 Rifaximin;Placebo
6 Plasma Citrulline as Quantitative Biomarker of HIV Associate Villous Atrophy in a Tropical Enteropathy Population Completed NCT00816842
7 WASH Benefits Kenya: A Cluster Randomized Controlled Trial of the Benefits of Sanitation, Water Quality, Handwashing, and Nutrition Interventions on Child Health and Development Completed NCT01704105
8 WASH Benefits Bangladesh: A Cluster Randomized Controlled Trial of the Benefits of Water, Sanitation, Hygiene Plus Nutrition Interventions on Child Growth Active, not recruiting NCT01590095

Search NIH Clinical Center for Tropical Sprue

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Medium chain triglycerides

Cochrane evidence based reviews: sprue, tropical

Genetic Tests for Tropical Sprue

Anatomical Context for Tropical Sprue

MalaCards organs/tissues related to Tropical Sprue:

40
Small Intestine, Testes, Liver, Pancreas, Colon, Whole Blood, Adrenal Gland

Publications for Tropical Sprue

Articles related to Tropical Sprue:

(show top 50) (show all 542)
# Title Authors PMID Year
1
Carbohydrate Intolerance and Disaccharidase Measurement - a Mini-Review. 61
31857738 2019
2
Synthesis and characterization of Abhraka (mica) bhasma by two different methods. 61
30826258 2019
3
Clinical, endoscopic, and histological differentiation between celiac disease and tropical sprue: A systematic review. 61
30069926 2019
4
[Tropical sprue: report of a case]. 61
30317744 2018
5
Immunohistochemical Expression of Antitissue Transglutaminase 2 in Tissue Injuries: An Interpretation Beyond Celiac Disease. 61
27753658 2018
6
Practical Approach to the Flattened Duodenal Biopsy. 61
29103535 2017
7
Epidemiological and clinical perspectives on irritable bowel syndrome in India, Bangladesh and Malaysia: A review. 61
29085223 2017
8
Pros and Cons While Looking Through an Asian Window on the Rome IV Criteria for Irritable Bowel Syndrome: Pros. 61
28672432 2017
9
Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link. 61
28513629 2017
10
Prevalence and Characteristics of Duodenal Villous Atrophy in Renal Transplant Patients Presenting With Persistent Diarrhea in a Developing Country. 61
26496241 2016
11
Olmesartan-associated sprue-like enteropathy: a systematic review with emphasis on histopathology. 61
26997446 2016
12
The maladies of malabsorption. 61
27195041 2016
13
Spectrum of chronic small bowel diarrhea with malabsorption in Indian subcontinent: is the trend really changing? 61
26884738 2016
14
Disorders associated with malabsorption of iron: A critical review. 61
26870134 2015
15
Infectious Gastroenteritis as a Risk Factor for Tropical Sprue and Malabsorption: A Case-Control Study. 61
26115751 2015
16
Early, non-refractory celiac disease associated with microscopic colitis and splenomegaly. 61
25933449 2015
17
Gastrointestinal complications in renal transplant recipients detected by endoscopic biopsies in a developing country. 61
25757628 2015
18
The biopsy pathology of non-coeliac enteropathy. 61
25234408 2015
19
Neil Hamilton Fairley KBE FRCP FRS (1891-1966): an outstanding tropical physician in the twentieth century. 61
24833541 2014
20
Distinguishing tropical sprue from celiac disease in returning travellers with chronic diarrhoea: a diagnostic challenge? 61
24889052 2014
21
Tropical sprue: revisiting an underrecognized disease. 61
24441659 2014
22
Neurologic manifestations of malabsorption syndromes. 61
24365342 2014
23
[Tropical sprue as a differential diagnosis to coeliac disease in a patient on immunosuppressive medication]. 61
24629612 2014
24
Tropical sprue in 2014: the new face of an old disease. 61
24781741 2014
25
Clinical utility of retrograde terminal ileum intubation in the evaluation of chronic non-bloody diarrhea. 61
23777610 2013
26
Pathology of celiac disease: a brief review. 61
25046883 2013
27
The clinical significance of duodenal lymphocytosis with normal villus architecture. 61
23991733 2013
28
A presentation of latent tropical sprue in a Canadian hospital. 61
23636074 2013
29
Tropical sprue: two cases report and review of literature. Has anything changed in the past 40 years? 61
23590053 2013
30
Pathogenesis of tropical sprue: a pilot study of antroduodenal manometry, duodenocaecal transit time & fat-induced ileal brake. 61
23481053 2013
31
Tropical sprue: a riddle wrapped in a mystery inside an enigma. 61
23481048 2013
32
Diarrhoea due to small bowel diseases. 61
23384804 2012
33
[Tropical sprue in an expatriate]. 61
22405324 2012
34
Spectrum of malabsorption in India--tropical sprue is still the leader. 61
22315745 2011
35
Is the ghost of tropical sprue re-surfacing after its obituary? 61
22315742 2011
36
Post-infectious irritable bowel syndrome: the past, the present and the future. 61
21443719 2011
37
Current spectrum of malabsorption syndrome in adults in India. 61
21369836 2011
38
Abnormal small intestinal permeability in patients with idiopathic malabsorption in tropics (tropical sprue) does not change even after successful treatment. 61
20411417 2011
39
The Face of Tropical Sprue in 2010. 61
20805939 2010
40
[Tropical sprue: an unusual differential diagnosis in chronic diarrhea]. 61
19572249 2009
41
Classification of villous atrophy with enhanced magnification endoscopy in patients with celiac disease and tropical sprue. 61
17643717 2007
42
[Tropical sprue]. 61
17336033 2007
43
Diagnostic value of endoscopy for the diagnosis of giardiasis and other intestinal diseases in patients with persistent diarrhea from tropical or subtropical areas. 61
17354120 2007
44
The pathology of malabsorption: current concepts. 61
17204022 2007
45
Tropical malabsorption. 61
17148698 2006
46
Tropical sprue in two foreign residents, with evidence of Tropheryma whippelii in one case. 61
16706950 2006
47
Monitoring nonresponsive patients who have celiac disease. 61
16644460 2006
48
Profile of chronic small-bowel diarrhea in adults in Western India: a hospital-based study. 61
17089618 2006
49
Malabsorption syndrome due to various causes is associated with antroduodenal hypomotility. 61
16763331 2006
50
[Tropical or non-tropical sprue?]. 61
16261708 2005

Variations for Tropical Sprue

Expression for Tropical Sprue

Search GEO for disease gene expression data for Tropical Sprue.

Pathways for Tropical Sprue

Pathways related to Tropical Sprue according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 TCN1 SLC46A1 CBLIF AMN
2
Show member pathways
11.79 TCN1 SLC46A1 CBLIF ALB
3 10.92 SLC46A1 GGH
4 10.78 SLC46A1 CBLIF
5 10.17 GAST CBLIF
6 10.12 TCN1 CBLIF AMN
7
Show member pathways
10.1 CBLIF AMN
8 9.65 GAST ATP4A

GO Terms for Tropical Sprue

Cellular components related to Tropical Sprue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TCN1 PYY GGH GAST CBLIF AMN
2 apical plasma membrane GO:0016324 9.26 SLC46A1 LCT CBLIF AMN
3 extracellular space GO:0005615 9.23 TCN1 PYY GGH GAST CBLIF ATP4A

Biological processes related to Tropical Sprue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proton transmembrane transport GO:1902600 9.58 SLC46A1 ATP4A ATP12A
2 cellular sodium ion homeostasis GO:0006883 9.43 ATP4A ATP12A
3 sodium ion export across plasma membrane GO:0036376 9.37 ATP4A ATP12A
4 cellular potassium ion homeostasis GO:0030007 9.32 ATP4A ATP12A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP4A ATP12A
6 cobalt ion transport GO:0006824 9.16 TCN1 CBLIF
7 cobalamin metabolic process GO:0009235 9.13 TCN1 CBLIF AMN
8 cobalamin transport GO:0015889 8.8 TCN1 CBLIF AMN

Molecular functions related to Tropical Sprue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
2 cobalamin binding GO:0031419 9.16 TCN1 CBLIF
3 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Tropical Sprue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....