MCID: TRP004
MIFTS: 37

Tropical Sprue

Categories: Rare diseases, Gastrointestinal diseases

Aliases & Classifications for Tropical Sprue

MalaCards integrated aliases for Tropical Sprue:

Name: Tropical Sprue 12 76 53 15
Sprue, Tropical 44 73
Idiopathic Tropical Malabsorption Syndrome 53
Tropical Steatorrhea 12
Tropical Enteropathy 53
Sprue - Tropical 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10607
ICD10 33 K90.1
ICD9CM 35 579.1
MeSH 44 D013182
NCIt 50 C45428
UMLS 73 C0038054

Summaries for Tropical Sprue

MalaCards based summary : Tropical Sprue, also known as sprue, tropical, is related to whipple disease and celiac disease 1. An important gene associated with Tropical Sprue is GGH (Gamma-Glutamyl Hydrolase), and among its related pathways/superpathways are Folate Metabolism and FOXA2 and FOXA3 transcription factor networks. The drugs Glycine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and pancreas, and related phenotype is liver/biliary system.

Wikipedia : 76 Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal... more...

Related Diseases for Tropical Sprue

Diseases related to Tropical Sprue via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 whipple disease 11.3
2 celiac disease 1 10.2
3 steatorrhea 10.1
4 diarrhea 10.1
5 macrocytic anemia 10.0
6 pernicious anemia 10.0
7 blind loop syndrome 10.0
8 megaloblastic anemia 10.0
9 gastroenteritis 10.0
10 pancreatitis 10.0
11 pneumonia 10.0
12 intussusception 9.8
13 hypokalemic periodic paralysis, type 1 9.8
14 myeloma, multiple 9.8
15 aging 9.8
16 malaria 9.8
17 exocrine pancreatic insufficiency 9.8
18 hepatitis 9.8
19 thrombocytopenia 9.8
20 vitamin b12 deficiency 9.8
21 colitis 9.8
22 microscopic colitis 9.8
23 mucositis 9.8
24 megacolon 9.8
25 dysentery 9.8
26 agammaglobulinemia 9.8
27 duodenitis 9.8
28 galactosemia 9.2 ALDOB GIF
29 nutritional deficiency disease 9.1 ALB GIF
30 small intestine lymphoma 9.0 ALDOB CD3E GIF

Comorbidity relations with Tropical Sprue via Phenotypic Disease Network (PDN):


Celiac Disease 1 Deficiency Anemia
Protein-Energy Malnutrition

Graphical network of the top 20 diseases related to Tropical Sprue:



Diseases related to Tropical Sprue

Symptoms & Phenotypes for Tropical Sprue

MGI Mouse Phenotypes related to Tropical Sprue:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.8 ALB ALDOB GIF

Drugs & Therapeutics for Tropical Sprue

Drugs for Tropical Sprue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 3 56-40-6 750
2 Vaccines Phase 3,Phase 1
3 Neurotransmitter Agents Phase 3
4 glutamine Nutraceutical Phase 3
5 Analgesics Phase 1, Phase 2
6 Analgesics, Non-Narcotic Phase 1, Phase 2
7 Anti-Inflammatory Agents Phase 1, Phase 2
8 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
9 Antirheumatic Agents Phase 1, Phase 2
10 Mesalamine Phase 1, Phase 2 89-57-6
11 Peripheral Nervous System Agents Phase 1, Phase 2
12
Rifaximin Approved, Investigational Not Applicable 80621-81-4 6436173
13
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
14 Anti-Bacterial Agents Not Applicable
15 Antibiotics, Antitubercular Not Applicable
16 Anti-Infective Agents Not Applicable
17 Gastrointestinal Agents Not Applicable
18 Nucleic Acid Synthesis Inhibitors Not Applicable
19 rifamycin SV Not Applicable
20 Rifamycins Not Applicable
21 Antibodies Not Applicable
22 Immunoglobulins Not Applicable
23 Micronutrients Not Applicable
24 Retinol palmitate Not Applicable
25 Trace Elements Not Applicable
26 Vitamins Not Applicable
27 Disinfectants Not Applicable
28 retinol Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in Bangladesh Completed NCT01375647 Phase 3
2 Intervention and Mechanisms of Alanyl-Glutamine for Inflammation, Nutrition, and Enteropathy Completed NCT01832636 Phase 3
3 Mesalamine in Environmental Enteropathy Completed NCT01841099 Phase 1, Phase 2 Mesalamine;Placebo granules
4 Exploration of the Biologic Basis for Underperformance of Oral Polio and Rotavirus Vaccines in INDIA (PROVIDE) Completed NCT01571505 Phase 1
5 Trial of Rifaximin in the Treatment of Tropical Enteropathy Completed NCT00858988 Not Applicable Rifaximin
6 Plasma Citrulline Concentration in Tropical Enteropathy Completed NCT00816842
7 WASH Benefits Kenya Completed NCT01704105 Not Applicable
8 Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa Active, not recruiting NCT03012048 Not Applicable
9 WASH Benefits Bangladesh Active, not recruiting NCT01590095 Not Applicable

Search NIH Clinical Center for Tropical Sprue

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: sprue, tropical

Genetic Tests for Tropical Sprue

Anatomical Context for Tropical Sprue

MalaCards organs/tissues related to Tropical Sprue:

41
Small Intestine, Testes, Pancreas, Liver, Colon, Adrenal Gland, Whole Blood

Publications for Tropical Sprue

Articles related to Tropical Sprue:

(show top 50) (show all 356)
# Title Authors Year
1
Post-infectious IBS, tropical sprue and small intestinal bacterial overgrowth: the missing link. ( 28513629 )
2017
2
Infectious Gastroenteritis as a Risk Factor for Tropical Sprue and Malabsorption: A Case-Control Study. ( 26115751 )
2015
3
Tropical sprue in 2014: the new face of an old disease. ( 24781741 )
2014
4
Tropical sprue: revisiting an underrecognized disease. ( 24441659 )
2014
5
Distinguishing tropical sprue from celiac disease in returning travellers with chronic diarrhoea: a diagnostic challenge? ( 24889052 )
2014
6
A presentation of latent tropical sprue in a Canadian hospital. ( 23636074 )
2013
7
Pathogenesis of tropical sprue: a pilot study of antroduodenal manometry, duodenocaecal transit time & fat-induced ileal brake. ( 23481053 )
2013
8
Tropical sprue: a riddle wrapped in a mystery inside an enigma. ( 23481048 )
2013
9
Tropical sprue: two cases report and review of literature. Has anything changed in the past 40 years? ( 23590053 )
2013
10
Abnormal small intestinal permeability in patients with idiopathic malabsorption in tropics (tropical sprue) does not change even after successful treatment. ( 20411417 )
2011
11
Is the ghost of tropical sprue re-surfacing after its obituary? ( 22315742 )
2011
12
Spectrum of malabsorption in India--tropical sprue is still the leader. ( 22315745 )
2011
13
The Face of Tropical Sprue in 2010. ( 20805939 )
2010
14
Classification of villous atrophy with enhanced magnification endoscopy in patients with celiac disease and tropical sprue. ( 17643717 )
2007
15
Tropical sprue in two foreign residents, with evidence of Tropheryma whippelii in one case. ( 16706950 )
2006
16
Tropical sprue. ( 16168231 )
2005
17
Tropical sprue in Far North Queensland. ( 15896184 )
2005
18
Tropical sprue: revisited. ( 15129872 )
2004
19
Tropical Sprue. ( 14723833 )
2004
20
Images of interest. Gastrointestinal: tropical sprue. ( 15304129 )
2004
21
What is tropical sprue? ( 12859716 )
2003
22
Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time. ( 12702046 )
2003
23
Treatment of tropical sprue: the work of Dr. Bailey K. Ashford examined in retrospect. ( 11776723 )
2001
24
Exocrine pancreatic insufficiency in tropical sprue. ( 11173897 )
2001
25
Tropical sprue in north Indian children. ( 11681110 )
2001
26
A perspective on tropical sprue. ( 11470001 )
2001
27
Tropical sprue after travel to Tanzania. ( 10689238 )
2000
28
Tropical sprue as a cause of traveler's diarrhea. ( 10921367 )
2000
29
Tropical sprue and subclinical enteropathy: a vision for the nineties. ( 9288443 )
1997
30
Association of lymphocytic (microscopic) colitis with tropical sprue. ( 8155860 )
1994
31
Hypokalemic periodic paralysis in association with tropical sprue: a case report. ( 7887139 )
1994
32
Quantitation of immunoglobulin-containing cells in the jejunal lamina propria in tropical sprue. ( 1556433 )
1992
33
Case records of the Massachusetts General Hospital weekly clinicopathological exercises. Case 29-1992. A 76-year-old woman with recurrent diarrhea several months after treatment for tropical sprue. ( 1608409 )
1992
34
Scalloping of the valvulae conniventes and mosaic mucosa in tropical sprue. ( 2070991 )
1991
35
Tropical sprue. ( 2205942 )
1990
36
Vincent Ketelaer did not describe tropical or non-tropical sprue or coeliac disease in his book De Aphthis Nostratibus seu Belgarum Sprouw. ( 2278120 )
1990
37
Jejunal surface pH measurements in tropical sprue. ( 2603196 )
1989
38
Intestinal transit in healthy southern Indian subjects and in patients with tropical sprue. ( 2920924 )
1989
39
Absorption of water and sodium and activity of adenosine triphosphatases in the rectal mucosa in tropical sprue. ( 2840363 )
1988
40
Tropical sprue in southern India. ( 3051540 )
1988
41
Role of bacterial toxins, bile acids, and free fatty acids in colonic water malabsorption in tropical sprue. ( 3568936 )
1987
42
HLA and tropical sprue. ( 2877326 )
1986
43
Tropical sprue--a clinical, biochemical and histopathological study. ( 3564147 )
1986
44
Epithelial cell renewal and turnover and relationship to morphologic abnormalities in jejunal mucosa in tropical sprue. ( 3709324 )
1986
45
Tropical sprue--its aetiology and pathogenesis. ( 3537290 )
1986
46
Intestinal absorption and unmediated permeation of sugars in post-infective tropical malabsorption (tropical sprue). ( 3949090 )
1986
47
Tropical sprue and multiple myeloma. ( 3462885 )
1986
48
Tropical sprue in visitor to Mexico. ( 2857825 )
1985
49
Functional and structural aspects of the epithelial lymphocyte, with implications for coeliac disease and tropical sprue. ( 2935927 )
1985
50
Aetiology and pathogenesis of tropical sprue: do viruses play a role? ( 4024249 )
1985

Variations for Tropical Sprue

Expression for Tropical Sprue

Search GEO for disease gene expression data for Tropical Sprue.

Pathways for Tropical Sprue

Pathways related to Tropical Sprue according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 ALB GIF
2 10.27 ALB ALDOB

GO Terms for Tropical Sprue

Sources for Tropical Sprue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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