MCID: TRY001
MIFTS: 55

Trypanosomiasis

Categories: Infectious diseases

Aliases & Classifications for Trypanosomiasis

MalaCards integrated aliases for Trypanosomiasis:

Name: Trypanosomiasis 12 56 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10113
ICD9CM 36 086 086.9
MeSH 45 D014352
SNOMED-CT 69 78940002
ICD10 34 B57.2
UMLS 74 C0041227

Summaries for Trypanosomiasis

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans.

MalaCards based summary : Trypanosomiasis is related to sleeping sickness and chagas disease. An important gene associated with Trypanosomiasis is APOL1 (Apolipoprotein L1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Aspirin and Enalaprilat have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related phenotypes are cellular and growth/size/body region

Wikipedia : 77 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Related Diseases for Trypanosomiasis

Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 410)
# Related Disease Score Top Affiliating Genes
1 sleeping sickness 33.6 AMD1 APOL1 HP HPR IL10 IL6
2 chagas disease 32.4 CALR CCL2 CXCL8 IFNG IL10 IL1B
3 leishmaniasis 30.8 IFNG IL10 IL1B IL4 TLR2 TLR9
4 schistosomiasis 30.4 IFNG IL10 IL2 IL4 TNF
5 endomyocardial fibrosis 30.4 IL10 IL4 TNF
6 transverse myelitis 30.3 CXCL8 IL10 IL6 TNF
7 mouth disease 30.3 IFNG IL10 IL1B IL6 TLR9 TNF
8 filarial elephantiasis 30.2 IL10 IL4 TLR2 TLR9
9 acquired immunodeficiency syndrome 30.1 IFNG IL10 IL1B IL2 IL6 TNF
10 uveitis 30.1 CCL2 IFNG IL10 IL4 TNF
11 filariasis 30.1 IFNG IL10 IL2 IL6 TLR2 TLR9
12 onchocerciasis 30.0 CALR IL2 IL4
13 toxoplasmosis 30.0 IFNG IL10 IL1B IL4 IL6 TLR2
14 human immunodeficiency virus infectious disease 29.9 IFNG IL10 IL2 IL6 TLR9 TNF
15 cutaneous leishmaniasis 29.8 IFNG IL10 IL4 TLR2 TLR9 TNF
16 brucellosis 29.6 CXCL8 IFNG IL10 IL2 IL4 IL6
17 malaria 29.5 CCL2 CXCL8 HP IDO1 IFNG IL10
18 visceral leishmaniasis 29.4 CXCL8 IFNG IL10 IL2 IL4 TLR2
19 trypanosomiasis, human east-african 12.4
20 trypanosomiasis, human west-african 12.1
21 eastern equine encephalitis 11.1
22 punctate inner choroidopathy 10.5 IL10 TNF
23 scorpion envenomation 10.5 IL6 TNF
24 cephalosporin allergy 10.5 IFNG IL10
25 chronic graft versus host disease 10.5 IFNG IL10 TNF
26 autoimmune myocarditis 10.5 IFNG IL6 TNF
27 staphylococcal toxic shock syndrome 10.5 IFNG IL1B TNF
28 multicentric castleman disease 10.5 IFNG IL10 IL6
29 castleman disease 10.5 IFNG IL10 IL6
30 trachoma 10.5 IDO1 IL10 TNF
31 eye lymphoma 10.5 IL10 IL6 TLR9
32 spotted fever 10.5 IFNG IL10 TNF
33 hand, foot and mouth disease 10.5 IFNG IL10 IL6
34 mucocutaneous leishmaniasis 10.5 IL10 TLR9 TNF
35 fascioliasis 10.5 IFNG IL10 IL1B
36 post-transplant lymphoproliferative disease 10.5 IL10 IL6 TNF
37 glossitis 10.5 IL1B IL6 TNF
38 laryngitis 10.5 IL1B IL6 TNF
39 fungal meningitis 10.5 CCL2 IFNG IL10
40 acute vascular insufficiency of intestine 10.5 IL1B IL6 TNF
41 acute transverse myelitis 10.5 CXCL8 IL10 IL6
42 osteosclerotic myeloma 10.5 IL1B IL6 TNF
43 exudative glomerulonephritis 10.5 CXCL8 IL1B TNF
44 poems syndrome 10.5 IL1B IL6 TNF
45 listeriosis 10.5 IDO1 IL6 TNF
46 leukomalacia 10.5 IL6 TNF
47 recurrent corneal erosion 10.4 CXCL8 IL1B IL6
48 bagassosis 10.4 CXCL8 IL1B IL6
49 hepatitis a 10.4 IFNG IL10 TNF
50 joint disorders 10.4 IL1B IL6 TNF

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to Trypanosomiasis

Symptoms & Phenotypes for Trypanosomiasis

MGI Mouse Phenotypes related to Trypanosomiasis:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.26 CALR HP IDO1 IFNG IL10 IL2
2 growth/size/body region MP:0005378 10.21 CALR IFNG IL10 IL1B IL2 IL4
3 cardiovascular system MP:0005385 10.19 CALR HP IDO1 IFNG IL10 IL1B
4 hematopoietic system MP:0005397 10.18 HP IDO1 IFNG IL10 IL1B IL2
5 homeostasis/metabolism MP:0005376 10.18 CALR HP IDO1 IFNG IL10 IL1B
6 immune system MP:0005387 10.13 CCL2 HP IDO1 IFNG IL10 IL1B
7 digestive/alimentary MP:0005381 10.06 IFNG IL10 IL2 IL4 IL6 TLR2
8 mortality/aging MP:0010768 9.97 CALR HP IFNG IL10 IL1B IL2
9 liver/biliary system MP:0005370 9.91 HP IFNG IL10 IL2 IL4 IL6
10 neoplasm MP:0002006 9.56 HP IFNG IL10 IL1B IL2 IL6
11 renal/urinary system MP:0005367 9.23 HP IDO1 IFNG IL4 IL6 PREP

Drugs & Therapeutics for Trypanosomiasis

Drugs for Trypanosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Enalaprilat Approved Phase 4 76420-72-9 6917719
3
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
4
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
5
Warfarin Approved Phase 4 81-81-2 6691 54678486
6
Ornithine Approved, Nutraceutical Phase 4,Phase 2,Phase 3 3184-13-2, 70-26-8 6262
7
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
8 Nifurtimox Investigational Phase 4,Phase 2,Phase 3,Phase 1 23256-30-6
9
Coumarin Experimental Phase 4 91-64-5 323
10 Peripheral Nervous System Agents Phase 4,Phase 3
11 Anti-Inflammatory Agents Phase 4
12 Fibrinolytic Agents Phase 4
13 Cyclooxygenase Inhibitors Phase 4
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4
15 Antipyretics Phase 4
16 Analgesics Phase 4
17 Platelet Aggregation Inhibitors Phase 4
18 Antirheumatic Agents Phase 4,Phase 2
19 Analgesics, Non-Narcotic Phase 4
20 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Benzonidazole Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Protective Agents Phase 4,Phase 3
27 Antihypertensive Agents Phase 4,Phase 3
28 Calcium, Dietary Phase 4
29 Adrenergic Agents Phase 4,Phase 3
30 Adrenergic alpha-Antagonists Phase 4
31 Neurotransmitter Agents Phase 4,Phase 3
32 calcium channel blockers Phase 4
33 Angiotensin-Converting Enzyme Inhibitors Phase 4
34 Natriuretic Peptide, Brain Phase 4
35 Hormones Phase 4,Phase 2
36
protease inhibitors Phase 4
37 HIV Protease Inhibitors Phase 4
38 Adrenergic alpha-1 Receptor Antagonists Phase 4
39 Adrenergic beta-Antagonists Phase 4,Phase 3
40 Adrenergic Antagonists Phase 4,Phase 3
41 Antioxidants Phase 4,Phase 3
42 Vasodilator Agents Phase 4,Phase 3,Not Applicable
43 Anticoagulants Phase 4
44
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
45
Amiodarone Approved, Investigational Phase 3,Not Applicable 1951-25-3 2157
46
Coal tar Approved Phase 3 8007-45-2
47
Bisoprolol Approved Phase 3 66722-44-9 2405
48 Melarsoprol Investigational Phase 3 494-79-1
49 Trace Elements Phase 3
50 Nutrients Phase 3

Interventional clinical trials:

(show top 50) (show all 81)
# Name Status NCT ID Phase Drugs
1 Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS) Unknown status NCT01650792 Phase 4 Aspirin
2 Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Phase Completed NCT00906880 Phase 4 Nifurtimox-Eflronithine Combination Treatment (NECT)
3 Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease Completed NCT01755403 Phase 4 Benznidazole
4 Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease Completed NCT01678599 Phase 4 Benznidazole
5 Population Pharmacokinetics Study of Benznidazole in Children With Chagas'Disease Completed NCT01549236 Phase 4 Benznidazole 12,5mg or 100mg
6 Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease Terminated NCT01539161 Phase 4
7 Exercise Training in Chagas Cardiomyopathy Completed NCT01006473 Phase 4
8 A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
9 Outcomes of an Anticoagulation Clinic in an University Hospital Completed NCT01006486 Phase 4
10 Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal Study Unknown status NCT02169557 Phase 2, Phase 3 Fexinidazole
11 Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal Study Unknown status NCT02184689 Phase 2, Phase 3 fexinidazole
12 BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Unknown status NCT00123916 Phase 3 Benznidazole;Placebo
13 Eflornithine + Nifurtimox Late-Stage Human African Trypanosomiasis (HAT)in West Nile, Uganda Terminated NCT00489658 Phase 2, Phase 3 Eflornithine plus Nifurtimox combination therapy
14 Efficacy - Safety of Eflornithine-Nifurtimox Combination Versus Eflornithine to Treat Human African Trypanosomiasis Completed NCT00146627 Phase 3 Eflornithine;Nifurtimox
15 Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis Terminated NCT00330148 Phase 3 melarsoprol 1.8 mg/kg/d, 10d + nifurtimox 15/20 mg/kg/d, 10d;melarsoprol 1.8 mg/kg/d, 10d + eflornithine 400 mg/kg/d, 7d;nifurtimox 15/20 mg/kg/d 10d + eflornithine 400 mg/kg/d 7d
16 Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2 Completed NCT01685827 Phase 2, Phase 3 Fexinidazole;Nifurtimox;Eflornithine
17 Prospective Study on Efficacy and Safety of SCYX-7158 in Patients Infected by Human African Trypanosomiasis Due to T.b. Gambiense Recruiting NCT03087955 Phase 2, Phase 3 SCYX 7158
18 Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage Recruiting NCT03025789 Phase 3 Fexinidazole
19 CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) Recruiting NCT02369978 Phase 2, Phase 3 Nifurtimox;Benznidazole;Placebo
20 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
21 Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age Not yet recruiting NCT03672487 Phase 3 Benznidazole;Placebo Oral Tablet
22 Prospective Study of a Pediatric Nifurtimox Formulation for Chagas' Disease Active, not recruiting NCT02625974 Phase 3 Nifurtimox (BAYA2502);Nifurtimox (BAYA2502) followed by Placebo
23 Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial Completed NCT02386358 Phase 3 Benznidazole;Placebo
24 Physical Exercise Program in Chronic Chagas Heart Disease Completed NCT02517632 Phase 3
25 Selenium Treatment and Chagasic Cardiopathy (STCC) Recruiting NCT00875173 Phase 3 Selenium;Placebo (for Selenium)
26 Cardiac Rehabilitation in Chagas Heart Failure Completed NCT02516293 Phase 2, Phase 3
27 A Trial Testing Amiodarone in Chagas Cardiomiopathy Recruiting NCT03193749 Phase 3 Amiodarone Hydrochloride;Placebo Oral Tablet
28 Cell Therapy in Chagas Cardiomyopathy Terminated NCT00349271 Phase 3 Filgrastime (G-CSF);Standart therapy
29 Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Completed NCT00323973 Phase 3 Bisoprolol
30 Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease Unknown status NCT02498782 Phase 2 Fexinidazole;Placebo
31 Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease Unknown status NCT01489228 Phase 2 E1224;Benznidazole;Placebo
32 Trial of DB289 for the Treatment of Stage I African Trypanosomiasis Completed NCT00803933 Phase 2 DB289;Pentamidine
33 A Trial of DB289 for the Treatment of Stage I African Trypanosomiasis Completed NCT00802594 Phase 2 DB289
34 Oral Fexinidazole Dosing Regimens for the Treatment of Adults With Chronic Indeterminate Chagas Disease Recruiting NCT03587766 Phase 2 Fexinidazole;Placebo Oral Tablet
35 Colchicine for Patients With Chagas´ Disease( B1 Stage) Recruiting NCT03704181 Phase 2 Colchicine 0.5 MG twice day for one year;Placebo Oral Tablet
36 BENDITA BEnznidazole New Doses Improved Treatment and Associations Active, not recruiting NCT03378661 Phase 2 Benznidazole;E1224;E1224 Placebo;Benznidazole Placebo
37 Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease. Recruiting NCT03191162 Phase 2 Benznidazole
38 A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) Completed NCT01377480 Phase 2 Posaconazole;Placebo for posaconazole;Benznidazole
39 Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole Completed NCT01162967 Phase 2 Benznidazole;Posaconazole
40 Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy Enrolling by invitation NCT02154269 Phase 2 Treatment with G-CSF (Granulocyte colony stimulating factor);Placebo saline
41 Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the Fexinidazole Completed NCT00982904 Phase 1 Fexinidazole/Placebo
42 Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food Terminated NCT01483170 Phase 1 Tablets Fexinidazole;Placebo
43 Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158 Completed NCT01533961 Phase 1 SCYX-7158;Placebo
44 Bioequivalence Study - Reference Clinical Fexinidazole Tablet Versus Proposed Market Formulation Completed NCT02571062 Phase 1 Fexinidazole
45 Fexinidazole (1200mg) Bioavailability Under Different Food Intake Conditions Completed NCT01340157 Phase 1 Fexinidazole
46 Pharmacokinetic Drug-Drug Interaction Study Completed NCT03892213 Phase 1 Benznidazole;E1224
47 Study Will Evaluate the Relative Bioavailability, Safety, and Tolerability of Single Doses of Nifurtimox 30 mg Tablets Exhibiting Different in Vitro Dissolution Characteristics, and to Evaluate the Relative Bioavailability of Nifurtimox 30 mg and 120 mg Completed NCT03350295 Phase 1 Nifurtimox (Lampit, BAYA2502)
48 Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study Not yet recruiting NCT03334838 Phase 1 Nifurtimox (Lampit, BAYA2502)
49 Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients Completed NCT02606864 Phase 1 Nifurtimox (BAYa2502)
50 Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients Completed NCT01927224 Phase 1 Nifurtimox (BAYa2502) (4 x 30 mg tablet);Nifurtimox (BAYa2502) (slurry of 4 x 30 mg tablets in tap water);Nifurtimox (BAYa2502) (120 mg tablet)

Search NIH Clinical Center for Trypanosomiasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: trypanosomiasis

Genetic Tests for Trypanosomiasis

Anatomical Context for Trypanosomiasis

MalaCards organs/tissues related to Trypanosomiasis:

42
Testes, Brain, T Cells, B Cells, Spleen, Endothelial, Bone

Publications for Trypanosomiasis

Articles related to Trypanosomiasis:

(show top 50) (show all 1861)
# Title Authors Year
1
American Trypanosomiasis and Chagas disease: sexual transmission. ( 30664986 )
2019
2
American Trypanosomiasis (Chagas Disease). ( 30712757 )
2019
3
Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon. ( 30908482 )
2019
4
Trans-sialidase Protein as a Potential Serological Marker for African Trypanosomiasis. ( 30604107 )
2019
5
Triazolopyrimidines and Imidazopyridines: Structure-Activity Relationships and in Vivo Efficacy for Trypanosomiasis. ( 30655955 )
2019
6
Human African Trypanosomiasis: Progress and Stagnation. ( 30712768 )
2019
7
Integration of Human African Trypanosomiasis Control Activities into Primary Health Services in the Democratic Republic of the Congo: A Qualitative Study of Stakeholder Perceptions. ( 30719963 )
2019
8
Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis. ( 30740102 )
2019
9
Novel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model. ( 30763102 )
2019
10
Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection. ( 30779758 )
2019
11
Community-led data collection using Open Data Kit for surveillance of animal African trypanosomiasis in Shimba hills, Kenya. ( 30885271 )
2019
12
Indigofera oblongifolia protects against trypanosomiasis-induced spleen injury. ( 30898472 )
2019
13
QSAR study of anti-Human African Trypanosomiasis activity for 2-phenylimidazopyridines derivatives using DFT and Lipinski's descriptors. ( 30899832 )
2019
14
Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial. ( 30901321 )
2019
15
Melarsoprol Resistance in African Trypanosomiasis. ( 29705579 )
2018
16
Integrated cost-benefit analysis of tsetse control and herd productivity to inform control programs for animal African trypanosomiasis. ( 29514668 )
2018
17
A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller. ( 29688491 )
2018
18
No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations. ( 29470556 )
2018
19
Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo. ( 29897919 )
2018
20
African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System. ( 29497418 )
2018
21
Brain-penetrant, triazolopyrimidine and phenylpyrimidine microtubule-stabilizers as potential leads to treat human African trypanosomiasis. ( 29969537 )
2018
22
FDG PET/CT in a Case of Human African Trypanosomiasis (Sleeping Sickness). ( 29863573 )
2018
23
Trypanosomiasis in a Young Infant from Rural Gujarat, India. ( 29396940 )
2018
24
Oral fexinidazole for human African trypanosomiasis. ( 29353603 )
2018
25
The impact of passive case detection on the transmission dynamics of gambiense Human African Trypanosomiasis. ( 29624584 )
2018
26
A Phase III Diagnostic Accuracy Study of a Rapid Diagnostic Test for Diagnosis of Second-Stage Human African Trypanosomiasis in the Democratic Republic of the Congo. ( 29246478 )
2018
27
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). ( 29169674 )
2018
28
Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis. ( 29744736 )
2018
29
Human African trypanosomiasis: How do the parasites enter and cause dysfunctions of the nervous system in murine models? ( 29870779 )
2018
30
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides. ( 29191556 )
2018
31
Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis. ( 29701144 )
2018
32
A multicentre, randomised, non-inferiority clinical trial comparing a nifurtimox-eflornithine combination to standard eflornithine monotherapy for late stage Trypanosoma brucei gambiense human African trypanosomiasis in Uganda. ( 29471865 )
2018
33
Human African Trypanosomiasis in Emigrant Returning to China from Gabon, 2017. ( 29350158 )
2018
34
Socioeconomic benefit to individuals of achieving 2020 targets for four neglected tropical diseases controlled/eliminated by innovative and intensified disease management: Human African trypanosomiasis, leprosy, visceral leishmaniasis, Chagas disease. ( 29534061 )
2018
35
A meta-analysis of the prevalence of African animal trypanosomiasis in Nigeria from 1960 to 2017. ( 29720251 )
2018
36
The development of high resolution maps of tsetse abundance to guide interventions against human African trypanosomiasis in northern Uganda. ( 29884213 )
2018
37
The structure of serum resistance-associated protein and its implications for human African trypanosomiasis. ( 29358741 )
2018
38
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial. ( 29113731 )
2018
39
Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria. ( 30453246 )
2018
40
Applying Loop-mediated Isothermal Amplification (LAMP) in the Diagnosis of Malaria, Leishmaniasis and Trypanosomiasis as Point-of-Care Tests (POCTs). ( 30360713 )
2018
41
Advanced in silico methods for the development of anti-leishmaniasis and anti-trypanosomiasis agents. ( 30378482 )
2018
42
Parasitological and Molecular Detection of Canine Trypanosomiasis From Riyadh Province, Saudi Arabia. ( 29990441 )
2018
43
Integrating innovations: a qualitative analysis of referral non-completion among rapid diagnostic test-positive patients in Uganda's human African trypanosomiasis elimination programme. ( 30119700 )
2018
44
Clinical management of East African trypanosomiasis in South Africa: Lessons learned. ( 30153486 )
2018
45
The activity of Artemisia spp. and their constituents against Trypanosomiasis. ( 30166103 )
2018
46
A systematic review and meta-analysis of small ruminant and porcine trypanosomiasis prevalence in sub-Saharan Africa (1986 to 2018). ( 30179607 )
2018
47
The Long Wait for a New Drug for Human African Trypanosomiasis. ( 30181071 )
2018
48
Molecular detection of equine trypanosomiasis in the Riyadh Province of Saudi Arabia. ( 30204053 )
2018
49
Innovative digital technologies for quality assurance of diagnosis of human African trypanosomiasis. ( 30212459 )
2018
50
Cost-effectiveness of using a rapid diagnostic test to screen for human African trypanosomiasis in the Democratic Republic of the Congo. ( 30240406 )
2018

Variations for Trypanosomiasis

Expression for Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for Trypanosomiasis

Pathways related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 CALR CCL2 CXCL8 HP IFNG IL10
2
Show member pathways
13.75 CCL2 CXCL8 IFNG IL10 IL1B IL2
3
Show member pathways
13.64 CCL2 CXCL8 IFNG IL10 IL1B IL2
4
Show member pathways
13.54 CCL2 CXCL8 IL10 IL1B IL2 IL4
5
Show member pathways
13.47 CCL2 CXCL8 IFNG IL10 IL1B IL2
6
Show member pathways
13.4 CCL2 CXCL8 IL10 IL1B IL2 IL4
7
Show member pathways
13.31 CALR CCL2 CXCL8 IFNG IL10 IL1B
8
Show member pathways
13.29 IFNG IL1B IL2 IL4 TLR2 TLR9
9
Show member pathways
13.07 CALR CCL2 CXCL8 IL1B IL6 TLR2
10
Show member pathways
13.04 CALR CXCL8 IFNG IL10 IL1B IL2
11 12.88 CXCL8 IFNG IL2 IL4 IL6
12
Show member pathways
12.82 CXCL8 IFNG IL1B IL6 TNF
13
Show member pathways
12.82 IL1B IL2 IL6 TLR2 TLR9 TNF
14
Show member pathways
12.76 CCL2 IFNG IL10 IL1B IL2 IL6
15
Show member pathways
12.76 IFNG IL10 IL1B IL2 IL4 IL6
16
Show member pathways
12.72 CCL2 CXCL8 IFNG IL1B IL2 IL4
17
Show member pathways
12.71 IFNG IL10 IL2 IL4 TNF
18
Show member pathways
12.61 IFNG IL10 IL1B IL2 IL4 IL6
19 12.58 CCL2 IDO1 IFNG IL10 IL1B IL2
20
Show member pathways
12.51 IFNG IL10 IL2 IL4 IL6
21
Show member pathways
12.51 CCL2 IFNG IL1B IL2 IL4 IL6
22
Show member pathways
12.5 CCL2 CXCL8 IFNG IL1B IL4 IL6
23
Show member pathways
12.44 IFNG IL10 IL1B IL4 TLR2 TNF
24
Show member pathways
12.43 CXCL8 IFNG IL1B IL6 TNF
25
Show member pathways
12.42 CXCL8 IFNG IL10 IL1B IL2 IL4
26 12.4 CALR IL2 IL6 TNF
27 12.4 IFNG IL10 IL1B IL6 TLR2 TLR9
28
Show member pathways
12.39 CXCL8 IL6 TLR2 TLR9 TNF
29
Show member pathways
12.38 IL10 IL1B IL2 IL6 TLR9 TNF
30
Show member pathways
12.36 CXCL8 IL1B IL6 TLR2 TNF
31 12.32 IFNG IL6 TLR2 TLR9 TNF
32 12.32 CXCL8 IL10 IL1B IL6 TNF
33
Show member pathways
12.3 CXCL8 IFNG IL1B IL4 IL6 TLR2
34
Show member pathways
12.24 CCL2 CXCL8 IFNG IL10 IL1B IL2
35
Show member pathways
12.23 IFNG IL1B IL4 IL6 TLR2 TNF
36 12.19 CCL2 IFNG IL1B TNF
37 12.18 IFNG IL10 IL2 IL4 IL6 TNF
38 12.16 CCL2 CXCL8 IL10 IL1B IL4 IL6
39
Show member pathways
12.15 IFNG IL10 IL1B IL2 IL6 TLR2
40
Show member pathways
12.14 IL1B IL2 TLR2 TLR9
41
Show member pathways
12.09 IFNG IL1B IL2 IL4
42 12.09 CCL2 CXCL8 IL1B IL6 TNF
43 12.09 CCL2 CXCL8 IFNG IL1B IL2 IL4
44 12.08 CCL2 IL1B IL6 TNF
45 12.06 CXCL8 IFNG IL1B IL6
46
Show member pathways
12.05 APOL1 CALR HP HPR
47 12.04 CXCL8 IFNG IL10 IL1B IL6 TLR2
48 12.01 IL1B IL4 IL6 TNF
49 12 CCL2 CXCL8 IFNG IL1B IL6 TLR2
50 11.99 IFNG IL10 IL2 IL6

GO Terms for Trypanosomiasis

Cellular components related to Trypanosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 APOL1 CALR CCL2 CXCL8 HP HPR
2 extracellular space GO:0005615 9.47 APOL1 CALR CCL2 CXCL8 HP HPR
3 blood microparticle GO:0072562 9.46 APOL1 HP HPR KNG1

Biological processes related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 IL1B IL6 TLR2 TLR9 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.97 CCL2 CXCL8 IL10 IL1B IL6 TNF
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.95 IL10 IL1B IL6 TNF
4 positive regulation of inflammatory response GO:0050729 9.93 IL2 TLR2 TLR9 TNF
5 response to organic substance GO:0010033 9.93 CALR HP HPR IL10 TNF
6 neutrophil chemotaxis GO:0030593 9.91 CCL2 CXCL8 IL1B
7 positive regulation of JNK cascade GO:0046330 9.91 IL1B TLR9 TNF
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 IFNG IL2 IL4 IL6
9 cellular response to organic cyclic compound GO:0071407 9.9 CCL2 IL1B TNF
10 regulation of insulin secretion GO:0050796 9.9 IFNG IL1B TNF
11 positive regulation of T cell proliferation GO:0042102 9.88 IL1B IL2 IL4 IL6
12 humoral immune response GO:0006959 9.88 CCL2 IFNG IL6 TNF
13 positive regulation of interferon-gamma production GO:0032729 9.87 IL1B IL2 TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 IFNG IL1B TNF
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.86 CCL2 IL1B TLR2 TNF
16 cytokine-mediated signaling pathway GO:0019221 9.86 CCL2 CXCL8 IL10 IL1B IL2 IL4
17 positive regulation of B cell proliferation GO:0030890 9.85 IL2 IL4 TLR9
18 positive regulation of phagocytosis GO:0050766 9.84 CALR IL1B TNF
19 protein kinase B signaling GO:0043491 9.84 CCL2 IL1B TNF
20 positive regulation of interleukin-8 production GO:0032757 9.83 IL1B TLR2 TLR9 TNF
21 positive regulation of interleukin-6 production GO:0032755 9.83 IL1B IL6 TLR2 TLR9 TNF
22 negative regulation of interleukin-6 production GO:0032715 9.82 IL10 TLR9 TNF
23 negative regulation of neurogenesis GO:0050768 9.81 IL1B IL6 TNF
24 positive regulation of interleukin-12 production GO:0032735 9.81 IDO1 IFNG TLR2 TLR9
25 regulation of signaling receptor activity GO:0010469 9.81 CCL2 CXCL8 IFNG IL10 IL1B IL2
26 positive regulation of glial cell proliferation GO:0060252 9.8 IL1B IL6 TNF
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.79 IFNG IL1B TNF
28 response to glucocorticoid GO:0051384 9.78 IL10 IL6 TNF
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 IL1B TNF
30 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.77 CCL2 TLR2 TLR9
31 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.77 CALR IL1B TLR2 TLR9 TNF
32 positive regulation of chemokine production GO:0032722 9.76 IL6 TLR2 TLR9 TNF
33 regulation of cytokine secretion GO:0050707 9.75 TLR2 TLR9
34 I-kappaB phosphorylation GO:0007252 9.75 TLR2 TLR9
35 PERK-mediated unfolded protein response GO:0036499 9.74 CCL2 CXCL8
36 polyamine biosynthetic process GO:0006596 9.74 AMD1 ODC1
37 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL2 IL6
38 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL1B TLR9
39 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR9 TNF
40 positive regulation of isotype switching to IgG isotypes GO:0048304 9.73 IL2 IL4
41 negative regulation of lipid storage GO:0010888 9.73 IL6 TNF
42 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF
43 polyamine metabolic process GO:0006595 9.72 AMD1 ODC1
44 positive regulation of chemokine biosynthetic process GO:0045080 9.72 IL1B TNF
45 positive regulation of neuroinflammatory response GO:0150078 9.72 IL1B IL6 TNF
46 negative regulation of interleukin-8 production GO:0032717 9.71 IL10 TLR9
47 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 IL10 IL4
48 regulation of establishment of endothelial barrier GO:1903140 9.71 IL1B TNF
49 negative regulation of cytokine secretion involved in immune response GO:0002740 9.71 IL10 TNF
50 positive regulation of fever generation GO:0031622 9.7 IL1B TNF

Molecular functions related to Trypanosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL10 IL2 IL4 IL6
2 cytokine activity GO:0005125 9.28 CCL2 CXCL8 IFNG IL10 IL1B IL2
3 signaling pattern recognition receptor activity GO:0008329 9.26 TLR2 TLR9
4 hemoglobin binding GO:0030492 8.96 HP HPR

Sources for Trypanosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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