MCID: TRY001
MIFTS: 50

Trypanosomiasis

Categories: Infectious diseases

Aliases & Classifications for Trypanosomiasis

MalaCards integrated aliases for Trypanosomiasis:

Name: Trypanosomiasis 12 54 43 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:10113
ICD9CM 34 086
MeSH 43 D014352
SNOMED-CT 67 78940002
ICD10 32 B57.2
UMLS 71 C0041227

Summaries for Trypanosomiasis

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans.

MalaCards based summary : Trypanosomiasis is related to sleeping sickness and chagas disease. An important gene associated with Trypanosomiasis is APOL1 (Apolipoprotein L1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Anti-Infective Agents and Antiprotozoal Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Trypanosomiasis

Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 800)
# Related Disease Score Top Affiliating Genes
1 sleeping sickness 34.5 ODC1 IL6 IL10 HPR HP APOL1
2 chagas disease 33.0 TNF TLR9 TLR4 TLR2 ODC1 MYD88
3 syphilis 31.7 TNF IL6 IFNG ALB
4 meningoencephalitis 31.6 TNF IL6 IL4 IL1B IL10 ALB
5 acute myocarditis 31.2 TNF IL1B IL10
6 congestive heart failure 31.2 TNF KNG1 IL6 IL1B ALB
7 encephalitis 31.1 TNF TLR2 IL6 IL4 IL1B IL10
8 acquired immunodeficiency syndrome 31.1 TNF IL6 IL1B IL10 IFNG ALB
9 myocarditis 31.1 TNF TLR4 IL6 IL4 IL1B IL10
10 deficiency anemia 31.1 TNF IL6 HP ALB
11 schistosomiasis 31.1 TNF IL4 IL10 IFNG CCL2 ALB
12 intracranial hypertension 31.0 TNF IL1B ALB
13 sleep disorder 31.0 TNF IL6 IL1B
14 mouth disease 30.9 TLR4 IL6 IL10 IFNG
15 pancytopenia 30.9 IL6 IFNG HP ALB
16 mucocutaneous leishmaniasis 30.9 TNF IL4 IL10 IFNG
17 nervous system disease 30.9 TNF IL6 IL1B IFNG ALB
18 glomerulonephritis 30.8 TLR9 IL1B CCL2 APOL1 ALB
19 human immunodeficiency virus infectious disease 30.8 TNF TLR9 IL4 IL10 IFNG IDO1
20 choroiditis 30.8 TNF IL10 IFNG
21 iridocyclitis 30.8 TNF IL6 IL10
22 myositis 30.8 TNF IL6 IL1B IFNG CXCL8 CCL2
23 spotted fever 30.8 TNF IL10 IFNG IDO1
24 chorioretinitis 30.8 TNF IL6 IL10 IFNG
25 lymphopenia 30.8 IL6 IL4 IL10 IFNG
26 endomyocardial fibrosis 30.8 TNF IL4 IL10
27 myelitis 30.8 TNF IL6 IL10 CXCL8
28 human immunodeficiency virus type 1 30.8 TNF IL10 IFNG IDO1 CCL2
29 disseminated intravascular coagulation 30.8 TNF IL6 IL10
30 transverse myelitis 30.7 TNF IL6 IL10 CXCL8
31 vasculitis 30.7 TNF IL6 IL10 CCL2
32 cryoglobulinemia 30.7 TNF IL6 IL1B IL10 IFNG
33 filariasis 30.7 TNF TLR9 TLR4 TLR2 IL6 IL10
34 tetanus 30.7 TNF IL6 IL4 IL1B IL10 IFNG
35 trichomoniasis 30.7 TNF IL6 IL1B CXCL8
36 thyroiditis 30.7 TNF IL6 IL4 IL10
37 alopecia 30.7 TNF IL4 IL1B IFNG
38 stroke, ischemic 30.7 TNF TLR4 IL6 IL1B ALB
39 central nervous system disease 30.6 TNF IL6 IL1B IFNG CCL2 ALB
40 echinococcosis 30.6 TNF TLR4 TLR2 IL6 IL10 IFNG
41 exanthem 30.6 TNF IL6 IL1B IL10 IFNG CXCL8
42 orchitis 30.6 TNF IL6 IL4 IL1B IL10
43 purpura 30.6 TNF IL6 IL4 IL10 IFNG
44 cysticercosis 30.6 TLR4 IL6 IL1B IL10
45 carpal tunnel syndrome 30.6 IL6 IL1B CCL2
46 brain edema 30.6 KNG1 IL6 IL1B IFNG ALB
47 diarrhea 30.5 TNF TLR4 IL6 IL1B IL10 IFNG
48 polyneuropathy 30.5 TNF IL6 IL1B ALB
49 filarial elephantiasis 30.5 TLR4 TLR2 IL4 IL10
50 narcolepsy 30.5 TNF IL6 IL1B CXCL8

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to Trypanosomiasis

Symptoms & Phenotypes for Trypanosomiasis

GenomeRNAi Phenotypes related to Trypanosomiasis according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.77 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.77 IL10 KNG1 ODC1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.77 KNG1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.77 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.77 TLR4
6 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.77 IL10 KNG1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.77 IL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 KNG1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.77 KNG1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.77 ODC1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.77 IL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-203 9.77 ODC1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.77 ODC1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.77 IL10
15 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.77 IL10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.77 TLR4
17 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.77 ODC1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.77 IL10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.77 IL10
20 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.77 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.77 IL10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.77 IL10 TLR4
23 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.77 IL10
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 IL10

MGI Mouse Phenotypes related to Trypanosomiasis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 ALB HP IDO1 IFNG IL10 IL4
2 homeostasis/metabolism MP:0005376 10.28 ALB HP IDO1 IFNG IL10 IL1B
3 cardiovascular system MP:0005385 10.25 ALB HP IDO1 IFNG IL10 IL1B
4 immune system MP:0005387 10.25 ALB CCL2 HP IDO1 IFNG IL10
5 hematopoietic system MP:0005397 10.23 HP IDO1 IFNG IL10 IL1B IL4
6 digestive/alimentary MP:0005381 10.18 ALB IFNG IL10 IL4 IL6 MYD88
7 mortality/aging MP:0010768 10.17 ALB AMD1 HP IFNG IL10 IL1B
8 liver/biliary system MP:0005370 10.07 ALB HP IFNG IL10 IL4 IL6
9 muscle MP:0005369 9.86 ALB IDO1 IFNG IL10 IL6 TLR2
10 neoplasm MP:0002006 9.85 ALB HP IFNG IL10 IL1B IL6
11 renal/urinary system MP:0005367 9.65 ALB HP IDO1 IFNG IL4 IL6
12 respiratory system MP:0005388 9.23 IFNG IL10 IL4 IL6 MYD88 TLR2

Drugs & Therapeutics for Trypanosomiasis

Drugs for Trypanosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Phase 4
2 Antiprotozoal Agents Phase 4
3 Antiparasitic Agents Phase 4
4 Immunologic Factors Phase 4
5 Immunosuppressive Agents Phase 4
6 Benzonidazole Phase 4
7
Ornithine Approved, Nutraceutical Phase 3 70-26-8, 3184-13-2 6262
8 Nifurtimox Investigational Phase 3 23256-30-6
9 Melarsoprol Investigational Phase 3 494-79-1
10 Immunoglobulins Phase 2, Phase 3
11 Antibodies Phase 2, Phase 3
12 polysaccharide-K Phase 2, Phase 3
13
Pentamidine Approved, Investigational Phase 2 100-33-4 4735
14
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
15
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
16
Permethrin Approved, Investigational Phase 2 52645-53-1 40326
17
Ivermectin Approved, Investigational, Vet_approved Phase 2 70288-86-7 6474909
18
Maleic acid Experimental, Investigational Phase 2 110-17-8, 110-16-7 444972
19
Pafuramidine Investigational Phase 2 186953-56-0
20 Antifungal Agents Phase 2
21 Insect Repellents Phase 2
22 Immunoglobulins, Intravenous
23 Immunoglobulin M
24 Immunoglobulin G

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Clinical Study to Assess the Clinical Tolerability, Feasibility and Effectiveness Under Field Conditions of the Combination of Nifurtimox and Eflornithine (NECT) for the Treatment of T.b.Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Stage Completed NCT00906880 Phase 4 Nifurtimox-Eflronithine Combination Treatment (NECT)
2 Optimization of Sampling Procedure for PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease Treated With Benznidazole in Aiquile, Bolivia Completed NCT01678599 Phase 4 Benznidazole
3 Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal Study Unknown status NCT02184689 Phase 2, Phase 3 fexinidazole
4 Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal Study Unknown status NCT02169557 Phase 2, Phase 3 Fexinidazole
5 Cardiovascular Health Investigation and Collaboration From Countries of America to Assess the Markers and Outcomes of Chagas Disease (CHICAMOCHA-3) - EQUITY (Equivalence of Usual Interventions for Trypanosomiasis) Unknown status NCT02369978 Phase 2, Phase 3 Nifurtimox;Benznidazole;Placebo
6 Efficacy and Safety of Fexinidazole Compared to Nifurtimox-Eflornithine Combination Therapy (NECT) in Patients With Late-stage Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: Pivotal, Non-inferiority, Multicentre, Randomised, Open-label Study Completed NCT01685827 Phase 2, Phase 3 Fexinidazole;Nifurtimox;Eflornithine
7 Clinical Study Comparing the Nifurtimox-Eflornithine Combination With the Standard Eflornithine Regimen for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis in the Meningoencephalitic Phase Completed NCT00146627 Phase 3 Eflornithine;Nifurtimox
8 Benznidazole Evaluation for Interrupting Trypanosomiasis - The BENEFIT Trial Completed NCT00123916 Phase 3 Benznidazole;Placebo
9 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
10 Efficacy and Safety of Fexinidazole in Patients With Human African Trypanosomiasis (HAT) Due to Trypanosoma Brucei Rhodesiense: a Multicentre, Open-label Clinical Trial Recruiting NCT03974178 Phase 2, Phase 3 Fexinidazole
11 Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring Recruiting NCT04099628 Phase 2, Phase 3
12 Efficacy and Safety Study of Acoziborole (SCYX-7158) in Patients With Human African Trypanosomiasis (HAT) Due to Trypanosoma Brucei Gambiense: a Multicentre, Open-label, Prospective Study Active, not recruiting NCT03087955 Phase 2, Phase 3 Acoziborole (SCYX-7158)
13 An Open-label Study Assessing Effectiveness, Safety and Compliance With Fexinidazole in Patients With Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage Active, not recruiting NCT03025789 Phase 3 Fexinidazole
14 Efficacy and Safety of an Eflornithine + Nifurtimox Combination for Treatment of Late-Stage Human African Trypanosomiasis (HAT) in West Nile, Uganda Terminated NCT00489658 Phase 2, Phase 3 Eflornithine plus Nifurtimox combination therapy
15 Clinical Trial Comparing the Therapeutic Combinations Melarsoprol-Nifurtimox, Melarsoprol-Eflornithine and Eflornithine-Nifurtimox in the Treatment of Gambiense Human African Trypanosomiasis in the Meningo-Encephalitic Phase Terminated NCT00330148 Phase 3 melarsoprol 1.8 mg/kg/d, 10d + nifurtimox 15/20 mg/kg/d, 10d;melarsoprol 1.8 mg/kg/d, 10d + eflornithine 400 mg/kg/d, 7d;nifurtimox 15/20 mg/kg/d 10d + eflornithine 400 mg/kg/d 7d
16 Phase 2, Randomized, Multicenter, Placebo-controlled, Safety and Efficacy Study to Evaluate Six Oral Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chronic Indeterminate Chagas Disease. Unknown status NCT02498782 Phase 2 Fexinidazole;Placebo
17 Phase II A Trial of DB289 for the Treatment of Stage I African Trypanosomiasis Completed NCT00802594 Phase 2 DB289
18 Phase II b Trial of DB289 for the Treatment of Stage I African Trypanosomiasis Completed NCT00803933 Phase 2 DB289;Pentamidine
19 A Within-subject Laboratory and Field Trial to Test the Use of Commercially Available Insect Repellents Against Contact From Musca Sorbens, the Putative Vector of Trachoma Completed NCT03813069 Phase 2
20 Phase 2 Randomized, Multicenter, Double-blinded Safety and Efficacy Study to Evaluate Oral Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chronic Indeterminate Chagas Disease Recruiting NCT03587766 Phase 2 Fexinidazole;Placebo Oral Tablet
21 Multicenter, Double-blind, Randomized, Placebo-controlled Study to Assess the Efficacy, Safety and Tolerability of Ivermectin in Mild Virus-positive Subjects (SARS-CoV)-2 With or Without Symptoms Not yet recruiting NCT04407507 Phase 2 Ivermectin;Placebo
22 Randomized, Double-blind, Placebo-controlled Sequential Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SCYX-7158 After Single Oral Ascending Doses in Healthy Male Volunteers Completed NCT01533961 Phase 1 SCYX-7158;Placebo
23 Randomized, Double-blind, Placebo-controlled Study of the Tolerability, and Pharmacokinetics of Fexinidazole After Single and Repeated Oral Ascending Doses, Completed by a Comparative Bioavailability Study of an Oral Suspension Versus a Tablet and an Exploratory Assessment of Food Effect, in Healthy Male Volunteers Completed NCT00982904 Phase 1 Fexinidazole/Placebo
24 Randomized, Open Study to Assess the Impact of Two Different Types of Food on the Relative Bioavailability of Fexinidazole Tablets After Single Oral Dose in Healthy Male Volunteers Completed NCT01340157 Phase 1 Fexinidazole
25 A Bioequivalence Study of the Reference Clinical Fexinidazole Tablet vs Proposed Market Formulation in Healthy Male Volunteers of African Sub-Saharan Origin:an Open-label,Randomized,Two-treatment,Single Dose,Replicate Design,Fed Condition Completed NCT02571062 Phase 1 Fexinidazole
26 An Open Label, Single-dose, Single Period Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of 14C-Acoziborole Recruiting NCT04270981 Phase 1 [14C]-acoziborole capsule, 240 mg containing NMT 9.25 kBq (250 nCi) 14C
27 Double-blind, Placebo Controlled, Randomized Multiple Ascending Dose Study in Fed Conditions for Ten Days Dosing Regimen With a Loading Dose to Evaluate the Safety, the Tolerability and the Pharmacokinetics of Oral Fexinidazole in 36 Healthy Male Sub-Saharan Volunteers. Terminated NCT01483170 Phase 1 Tablets Fexinidazole;Placebo
28 Abbott ESA Chagas Assay Post-Market Study Completed NCT01662362
29 Evaluation of Rapid Diagnostic Tests (RDT) in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases (NTD) in Patients Presenting With Persistent Fever (≥1 Week) in Cambodia, Nepal, Democratic Republic of the Congo and Sudan Completed NCT01766830
30 Epidemic History and Iatrogenic Transmission of Blood-borne Viruses Completed NCT02439918
31 Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP2 Passive Case Detection Recruiting NCT03356665
32 Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP4 Early Test-of-cure Active, not recruiting NCT03112655
33 Prospective Evaluation of a Rapid Diagnostic Test to Screen for Gambiense Human African Trypanosomiasis and Diagnose Plasmodium Falciparum Malaria Not yet recruiting NCT03394976

Search NIH Clinical Center for Trypanosomiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Pentamidine
Pentamidine Isethionate

Cochrane evidence based reviews: trypanosomiasis

Genetic Tests for Trypanosomiasis

Anatomical Context for Trypanosomiasis

MalaCards organs/tissues related to Trypanosomiasis:

40
Testes, Brain, T Cells, Heart, B Cells, Bone, Kidney

Publications for Trypanosomiasis

Articles related to Trypanosomiasis:

(show top 50) (show all 5408)
# Title Authors PMID Year
1
The prolyl oligopeptidase family. 61 54
11915948 2002
2
2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses. 61
32074064 2020
3
Diversity of trypanosomes in wildlife of the Kafue ecosystem, Zambia. 61
32420023 2020
4
Role of the translocase of the mitochondrial inner membrane in the import of tRNAs into mitochondria in Trypanosoma brucei. 61
32339625 2020
5
Ribose-5-phosphate isomerases: characteristics, structural features, and applications. 61
32533303 2020
6
Trypanocidal and leishmanicidal activity of six limonoids. 61
32277328 2020
7
A review of the systematics, species identification and diagnostics of the Trypanosomatidae using the maxicircle kinetoplast DNA: from past to present. 61
32333942 2020
8
Neglected Tropical Diseases in the Context of Climate Change in East Africa: A Systematic Scoping Review. 61
32228798 2020
9
Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. 61
32354742 2020
10
Fragment-based discovery of non-bisphosphonate binders of Trypanosoma brucei farnesyl pyrophosphate synthase. 61
32537808 2020
11
Screening Strategies for a Sustainable Endpoint for Gambiense Sleeping Sickness. 61
31876949 2020
12
Use of herbal remedies in the management of sleeping sickness in four northern provinces of Angola. 61
31743767 2020
13
Trypanosome infections in naturally infected horses and donkeys of three active sleeping sickness foci in the south of Chad. 61
32576240 2020
14
In-silico identification of fingerprint of pyrazolyl sulfonamide responsible for inhibition of N-myristoyltransferase using Monte Carlo method with index of ideality of correlation. 61
32579066 2020
15
Validation of ligands targeting metacaspase-2 (MCA2) from Trypanosoma brucei brucei and their application to MCA5 from T. congolense as possible trypanocides. 61
32197135 2020
16
Substrate promiscuity of polyketide synthase enables production of tsetse fly attractants 3-ethylphenol and 3-propylphenol by engineering precursor supply in yeast. 61
32561880 2020
17
Optimization of 2-(1H-imidazo-2-yl)piperazines series of Trypanosoma brucei growth inhibitors as potential treatment for the second stage of HAT. 61
32354566 2020
18
Structure-activity relationship exploration of 3'-deoxy-7-deazapurine nucleoside analogues as anti-Trypanosoma brucei agents. 61
32568511 2020
19
Development of Novel Benzodiazepine-Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense. 61
32329206 2020
20
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor. 61
32496217 2020
21
In vitro Treatment of a Murine Mammary Adenocarcinoma Cell Line with Recombinant Trypanosoma cruzi Calreticulin Promotes Immunogenicity and Phagocytosis. 61
32526557 2020
22
Basal Body Protein TbSAF1 Is Required for Microtubule Quartet Anchorage to the Basal Bodies in Trypanosoma brucei. 61
32518185 2020
23
Shelter dogs as indicators for Trypanosoma cruzi infection in an urban area of Aracaju, Brazil. 61
32526168 2020
24
Toosendanin relatives, trypanocidal principles from Meliae Cortex. 61
32529328 2020
25
Computational approaches for drug discovery against trypanosomatid-caused diseases. 61
32046803 2020
26
Nanotechnological interventions for treatment of trypanosomiasis in humans and animals. 61
32383004 2020
27
Inducible Germline IgMs Bridge Trypanosome Lytic Factor Assembly and Parasite Recognition. 61
32416060 2020
28
Monitoring the elimination of human African trypanosomiasis at continental and country level: Update to 2018. 61
32437391 2020
29
Drug Synergism: Studies of Combination of RK-52 and Curcumin against Rhodesain of Trypanosoma brucei rhodesiense. 61
32435388 2020
30
Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity. 61
32329788 2020
31
Spiro-containing derivatives show antiparasitic activity against Trypanosoma brucei through inhibition of the trypanothione reductase enzyme. 61
32437349 2020
32
The Change of Interleukin-6 Level-Related Genes and Pathways Induced by Exercise in Sedentary Individuals. 61
32401165 2020
33
Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis. 61
32456126 2020
34
TrypInDB: A searchable online resource of small molecule inhibitors against Trypanosoma sp. 61
32380213 2020
35
Indigofera oblongifolia as a fight against hepatic injury caused by murine trypanosomiasis. 61
32346351 2020
36
Chagas disease: Historic perspective. 61
32001300 2020
37
Development of Trypanosoma everetti in Culicoides biting midges. 61
32473117 2020
38
Microglia in neuropathology caused by protozoan parasites. 61
31682077 2020
39
Next-Generation Molecular Surveillance of TriTryp Diseases. 61
32191850 2020
40
The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targets. 61
32249457 2020
41
Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases. 61
32326257 2020
42
Sleeping Sickness at the Crossroads. 61
32276514 2020
43
Trypanosoma brucei colonizes the tsetse gut via an immature peritrophic matrix in the proventriculus. 61
32313202 2020
44
Evidence of the absence of human African trypanosomiasis in two northern districts of Uganda: Analyses of cattle, pigs and tsetse flies for the presence of Trypanosoma brucei gambiense. 61
32255793 2020
45
Activity of diphenyl ether benzyl amines against Human African Trypanosomiasis. 61
32179269 2020
46
Understanding the Role of the Diagnostic 'Reflex' in the Elimination of Human African Trypanosomiasis. 61
32244778 2020
47
Performance evaluation of a prototype rapid diagnostic test for combined detection of gambiense human African trypanosomiasis and malaria. 61
32251426 2020
48
Human African trypanosomiasis: the current situation in endemic regions and the risks for non-endemic regions from imported cases. 61
32338232 2020
49
An Active Follow-up Strategy for Serological Suspects of Human African Trypanosomiasis with Negative Parasitology Set up by a Health Zone Team in the Democratic Republic of Congo. 61
32260405 2020
50
Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds. 61
32196340 2020

Variations for Trypanosomiasis

Expression for Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for Trypanosomiasis

Pathways related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 TNF TLR9 TLR4 TLR2 MYD88 IL6
2
Show member pathways
13.75 TNF TLR4 IL6 IL4 IL1B IL10
3
Show member pathways
13.6 TNF IL6 IL4 IL1B IL10 IFNG
4
Show member pathways
13.55 TNF TLR9 TLR4 TLR2 MYD88 IL6
5
Show member pathways
13.48 TNF MYD88 IL6 IL4 IL1B IL10
6
Show member pathways
13.37 TNF IL6 IL4 IL1B IL10 CXCL8
7
Show member pathways
13.33 TNF TLR9 TLR4 TLR2 MYD88 IL4
8
Show member pathways
13.2 TNF TLR9 TLR4 TLR2 MYD88 KNG1
9
Show member pathways
13.09 TNF TLR4 TLR2 MYD88 IL6 IL1B
10
Show member pathways
12.99 TNF IL6 IL4 IL1B IL10 IFNG
11
Show member pathways
12.99 TNF TLR9 TLR4 TLR2 MYD88 IL6
12 12.97 TNF TLR9 TLR2 MYD88 IL6 IL1B
13
Show member pathways
12.9 TNF TLR9 TLR4 TLR2 MYD88 IL6
14
Show member pathways
12.86 TNF TLR9 TLR4 TLR2 MYD88 IL6
15
Show member pathways
12.79 TNF TLR4 TLR2 IL6 IL4 IL1B
16
Show member pathways
12.76 TNF TLR9 TLR4 TLR2 MYD88 IL6
17
Show member pathways
12.73 TNF IL6 IL1B IL10 IFNG CCL2
18
Show member pathways
12.72 TNF TLR9 TLR4 TLR2 MYD88 IL1B
19 12.67 TNF TLR9 TLR2 MYD88 IL4 IL1B
20
Show member pathways
12.55 TNF TLR2 IL6 IL4 IL1B IFNG
21
Show member pathways
12.53 TNF IL6 IL4 IL1B IFNG CCL2
22 12.52 TNF TLR4 MYD88 IL1B CXCL8
23 12.51 TNF TLR9 TLR4 TLR2 MYD88 IL6
24
Show member pathways
12.5 TNF TLR4 MYD88 IL6 IL1B IFNG
25
Show member pathways
12.47 TNF TLR9 TLR4 TLR2 MYD88 IL6
26
Show member pathways
12.46 TNF IL6 IL10 CXCL8 CCL2
27 12.45 TNF TLR4 MYD88 IL6 IL1B CXCL8
28
Show member pathways
12.45 TNF TLR4 TLR2 MYD88 IL4 IL1B
29
Show member pathways
12.44 TNF IL6 IL4 IL1B IL10 IFNG
30 12.44 TNF TLR4 MYD88 IL6 IL1B CXCL8
31
Show member pathways
12.39 TNF TLR9 MYD88 IL6 IL1B IL10
32 12.37 TNF TLR9 TLR4 TLR2 IL6 IFNG
33 12.32 TNF IL6 IL1B IL10 CXCL8
34
Show member pathways
12.29 TNF TLR4 IL1B IFNG
35 12.23 TNF TLR9 TLR4 TLR2 MYD88 IL6
36 12.21 TNF IL6 IL4 IL1B IL10 CXCL8
37 12.19 TNF IL1B IFNG CCL2
38 12.19 TNF TLR4 MYD88 IL6 IL1B IL10
39 12.18 TNF TLR4 IL6 IL4 IL1B IFNG
40 12.16 TNF IL6 IL4 IL10 IFNG
41
Show member pathways
12.14 TLR9 TLR4 TLR2 IL1B
42 12.11 TNF TLR4 MYD88 IL1B CXCL8
43 12.09 TNF IL6 IL1B CCL2
44 12.09 TNF IL6 IL1B CXCL8 CCL2
45 12.07 IL6 IL1B IFNG CXCL8
46
Show member pathways
12.07 TLR9 TLR4 TLR2 IL6 IL4 IL1B
47
Show member pathways
12.07 TNF TLR9 TLR4 TLR2 MYD88 IL6
48
Show member pathways
12.06 HPR HP APOL1 ALB
49
Show member pathways
12.06 TNF TLR9 TLR4 TLR2 IL6 IL1B
50 12.03 TNF IL6 IL4 IL1B

GO Terms for Trypanosomiasis

Cellular components related to Trypanosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNF TLR9 KNG1 IL6 IL4 IL1B
2 blood microparticle GO:0072562 9.55 KNG1 HPR HP APOL1 ALB
3 extracellular space GO:0005615 9.44 TNF KNG1 IL6 IL4 IL1B IL10

Biological processes related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.39 TLR9 TLR4 TLR2 MYD88 IL6 IL4
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.31 TNF TLR9 TLR4 TLR2 IL6 IL4
3 immune system process GO:0002376 10.24 TLR9 TLR4 TLR2 MYD88 IDO1 HP
4 positive regulation of gene expression GO:0010628 10.18 TNF TLR9 TLR4 TLR2 MYD88 IL6
5 negative regulation of cell proliferation GO:0008285 10.16 TLR2 IL6 IL1B IL10 CXCL8
6 defense response to bacterium GO:0042742 10.11 TNF TLR9 TLR4 MYD88 IL10 HP
7 cytokine-mediated signaling pathway GO:0019221 10.11 TNF MYD88 IL6 IL4 IL1B IL10
8 response to lipopolysaccharide GO:0032496 10.08 TLR4 TLR2 MYD88 IL1B IL10 IDO1
9 cellular protein metabolic process GO:0044267 10.07 KNG1 IL6 APOL1 ALB
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.07 TNF TLR9 TLR4 MYD88 IL1B
11 receptor-mediated endocytosis GO:0006898 10.04 HPR HP APOL1 ALB
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.04 TNF TLR9 TLR4 TLR2 MYD88 IL6
13 positive regulation of DNA-binding transcription factor activity GO:0051091 10.01 TNF IL6 IL1B IL10
14 defense response to Gram-positive bacterium GO:0050830 10.01 TNF TLR2 MYD88 IL6
15 response to virus GO:0009615 10.01 TNF ODC1 MYD88 IFNG
16 positive regulation of JNK cascade GO:0046330 10.01 TNF TLR9 TLR4 MYD88 IL1B
17 positive regulation of inflammatory response GO:0050729 10.01 TNF TLR9 TLR4 TLR2 IL1B IFNG
18 cellular response to lipopolysaccharide GO:0071222 10.01 TNF TLR4 MYD88 IL6 IL1B IL10
19 response to organic substance GO:0010033 9.99 TNF IL10 HPR HP
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.97 TNF IL6 IL4 IFNG
21 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.97 TNF TLR9 TLR4 TLR2 IL1B
22 positive regulation of interleukin-6 secretion GO:2000778 9.97 TNF TLR4 TLR2 IL1B IFNG
23 humoral immune response GO:0006959 9.96 TNF IL6 IFNG CCL2
24 cellular response to mechanical stimulus GO:0071260 9.95 TLR4 MYD88 IL1B
25 neutrophil chemotaxis GO:0030593 9.95 IL1B CXCL8 CCL2
26 positive regulation of tumor necrosis factor production GO:0032760 9.95 TLR9 TLR4 TLR2 MYD88
27 regulation of insulin secretion GO:0050796 9.94 TNF IL1B IFNG
28 cellular response to organic cyclic compound GO:0071407 9.94 TNF IL1B CCL2
29 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.94 TNF TLR9 TLR4
30 response to glucocorticoid GO:0051384 9.94 TNF IL6 IL10
31 toll-like receptor signaling pathway GO:0002224 9.94 TLR9 TLR4 TLR2 MYD88
32 positive regulation of nitric oxide biosynthetic process GO:0045429 9.94 TNF TLR4 IL1B IFNG
33 positive regulation of T cell proliferation GO:0042102 9.93 IL6 IL4 IL1B
34 positive regulation of smooth muscle cell proliferation GO:0048661 9.93 TNF MYD88 IL6
35 negative regulation of interleukin-6 production GO:0032715 9.93 TNF TLR9 TLR4 IL10
36 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.92 TLR9 TLR4 TLR2 MYD88
37 microglial cell activation GO:0001774 9.92 TNF TLR2 IL4 IFNG
38 positive regulation of phagocytosis GO:0050766 9.91 TNF IL1B IFNG
39 positive regulation of interferon-gamma production GO:0032729 9.91 TNF TLR4 IL1B
40 positive regulation of interleukin-10 production GO:0032733 9.91 TLR9 TLR4 TLR2 IL4
41 positive regulation of B cell proliferation GO:0030890 9.9 TLR9 TLR4 IL4
42 protein kinase B signaling GO:0043491 9.9 TNF IL1B CCL2
43 immune response GO:0006955 9.9 TNF TLR9 TLR4 TLR2 IL6 IL4
44 positive regulation of cytokine secretion GO:0050715 9.89 TNF IL10 IFNG
45 positive regulation of JAK-STAT cascade GO:0046427 9.89 TNF IL6 IL10
46 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.89 TNF TLR4 MYD88 IL6
47 negative regulation of neurogenesis GO:0050768 9.88 TNF IL6 IL1B
48 positive regulation of interferon-beta production GO:0032728 9.88 TLR9 TLR4 TLR2
49 positive regulation of interleukin-12 production GO:0032735 9.88 TLR9 TLR4 TLR2 IFNG IDO1
50 positive regulation of glial cell proliferation GO:0060252 9.86 TNF IL6 IL1B

Molecular functions related to Trypanosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Toll-like receptor binding GO:0035325 9.32 TLR2 MYD88
2 hemoglobin binding GO:0030492 9.26 HPR HP
3 cytokine activity GO:0005125 9.23 TNF IL6 IL4 IL1B IL10 IFNG
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2
5 interleukin-1 receptor binding GO:0005149 9.13 TLR9 MYD88 IL1B

Sources for Trypanosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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