MCID: TRY001
MIFTS: 54

Trypanosomiasis

Categories: Infectious diseases

Aliases & Classifications for Trypanosomiasis

MalaCards integrated aliases for Trypanosomiasis:

Name: Trypanosomiasis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10113
ICD10 33 B57.2
ICD9CM 35 086 086.9
MeSH 44 D014352
UMLS 73 C0041227

Summaries for Trypanosomiasis

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans.

MalaCards based summary : Trypanosomiasis is related to sleeping sickness and leishmaniasis. An important gene associated with Trypanosomiasis is APOL1 (Apolipoprotein L1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Carvedilol and Enalapril have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and brain, and related phenotypes are Reduced mammosphere formation and cellular

Wikipedia : 76 Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasitic... more...

Related Diseases for Trypanosomiasis

Diseases related to Trypanosomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 372)
# Related Disease Score Top Affiliating Genes
1 sleeping sickness 32.5 AMD1 APOL1 HP HPR IL10 IL6
2 leishmaniasis 30.8 IFNG IL10 IL1B IL4 TLR9 TNF
3 endomyocardial fibrosis 30.6 IL10 IL4 TNF
4 chagas disease 30.5 CALR CCL2 CCL3 CXCL8 IFNG IL10
5 cutaneous leishmaniasis 30.1 IFNG IL10 IL4 TLR9 TNF
6 uveitis 30.0 CCL2 IFNG IL10 IL4 TNF
7 toxoplasmosis 29.8 IFNG IL10 IL1B IL4 IL6 TLR9
8 onchocerciasis 29.3 CALR IL2 IL4
9 filariasis 29.0 ALB IFNG IL10 IL2 IL6 TLR9
10 brucellosis 28.8 CXCL8 IFNG IL10 IL2 IL4 IL6
11 schistosomiasis 28.3 ALB CCL3 IFNG IL10 IL2 IL4
12 visceral leishmaniasis 27.9 ALB CXCL8 IFNG IL10 IL1B IL2
13 malaria 25.4 ALB AMD1 CCL2 CCL3 CXCL8 HP
14 trypanosomiasis, human east-african 12.2
15 trypanosomiasis, human west-african 11.9
16 punctate inner choroidopathy 11.1 IL10 TNF
17 scorpion envenomation 11.0 IL6 TNF
18 staphylococcal toxic shock syndrome 11.0 IFNG IL1B TNF
19 eye lymphoma 11.0 IL10 IL6 TLR9
20 multicentric castleman disease 11.0 IFNG IL10 IL6
21 mucocutaneous leishmaniasis 11.0 IL10 TLR9 TNF
22 spotted fever 11.0 IFNG IL10 TNF
23 hand, foot and mouth disease 11.0 IFNG IL10 IL6
24 trachoma 11.0 IDO1 IL10 TNF
25 post-transplant lymphoproliferative disease 10.9 IL10 IL6 TNF
26 acute transverse myelitis 10.9 CXCL8 IL10 IL6
27 laryngitis 10.9 IL1B IL6 TNF
28 eastern equine encephalitis 10.9
29 acute vascular insufficiency of intestine 10.9 IL1B IL6 TNF
30 poems syndrome 10.9 IL1B IL6 TNF
31 osteosclerotic myeloma 10.9 IL1B IL6 TNF
32 scrub typhus 10.9 IL10 IL1B TNF
33 recurrent corneal erosion 10.9 CXCL8 IL1B IL6
34 primary peritoneal carcinoma 10.9 CXCL8 IFNG IL10
35 bagassosis 10.9 CXCL8 IL1B IL6
36 louse-borne relapsing fever 10.9 CXCL8 IL6 TNF
37 radiculopathy 10.9 CXCL8 IL10 IL6
38 joint disorders 10.9 IL1B IL6 TNF
39 adult-onset still's disease 10.9 IL1B IL6 TNF
40 denture stomatitis 10.9 CCL2 CXCL8 IL6
41 leukomalacia 10.9 IL6 TNF
42 dental pulp disease 10.9 CXCL8 IL1B TNF
43 post-thrombotic syndrome 10.9 CCL2 IL6 TLR9
44 vaginal disease 10.8 CXCL8 IL1B IL6
45 fasciitis 10.8 CXCL8 IL6 TNF
46 plasmodium vivax malaria 10.8 IFNG IL10 IL6 TNF
47 vaginitis 10.8 CXCL8 IL1B IL6
48 pericarditis 10.8 IL1B IL6 TNF
49 mixed connective tissue disease 10.8 IFNG IL10 IL6 TNF
50 echinococcosis 10.8 IFNG IL10 IL6 TNF

Graphical network of the top 20 diseases related to Trypanosomiasis:



Diseases related to Trypanosomiasis

Symptoms & Phenotypes for Trypanosomiasis

GenomeRNAi Phenotypes related to Trypanosomiasis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CALR CCL2 CCL3 CXCL8 IDO1

MGI Mouse Phenotypes related to Trypanosomiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.23 ALB CALR HP IDO1 IFNG IL10
2 homeostasis/metabolism MP:0005376 10.18 ALB CALR HP IDO1 IFNG IL10
3 hematopoietic system MP:0005397 10.14 IL6 TF TLR9 TNF IL10 IL1B
4 immune system MP:0005387 10.06 IL4 IL6 TLR9 TNF CCL2 HP
5 digestive/alimentary MP:0005381 10.03 ALB IFNG IL10 IL2 IL4 IL6
6 mortality/aging MP:0010768 9.97 ALB CALR HP IFNG IL10 IL1B
7 liver/biliary system MP:0005370 9.86 IL10 IL2 IL4 IL6 TNF ALB
8 neoplasm MP:0002006 9.56 ALB HP IFNG IL10 IL1B IL2
9 renal/urinary system MP:0005367 9.17 ALB HP IDO1 IFNG IL4 IL6

Drugs & Therapeutics for Trypanosomiasis

Drugs for Trypanosomiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
3
Enalaprilat Approved Phase 4 76420-72-9 6917719
4
Warfarin Approved Phase 4 81-81-2 6691 54678486
5
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
6
Ornithine Approved, Nutraceutical Phase 4,Phase 3,Phase 2 70-26-8, 3184-13-2 6262
7 Nifurtimox Investigational Phase 4,Phase 3,Phase 2,Phase 1 23256-30-6
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Benzonidazole Phase 4,Phase 3,Phase 2,Not Applicable
12 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Adrenergic Agents Phase 4,Phase 3
14 Adrenergic alpha-1 Receptor Antagonists Phase 4
15 Adrenergic alpha-Antagonists Phase 4
16 Adrenergic Antagonists Phase 4,Phase 3
17 Adrenergic beta-Antagonists Phase 4,Phase 3
18 Angiotensin-Converting Enzyme Inhibitors Phase 4
19 Antihypertensive Agents Phase 4,Phase 3
20 HIV Protease Inhibitors Phase 4
21 Natriuretic Peptide, Brain Phase 4
22 Neurotransmitter Agents Phase 4,Phase 3
23
protease inhibitors Phase 4
24 Vasodilator Agents Phase 4,Phase 3,Not Applicable
25 Anticoagulants Phase 4
26 Peripheral Nervous System Agents Phase 4,Phase 3
27 Analgesics Phase 4
28 Analgesics, Non-Narcotic Phase 4
29 Anti-Inflammatory Agents Phase 4
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4
31 Antipyretics Phase 4
32 Antirheumatic Agents Phase 4
33 Cyclooxygenase Inhibitors Phase 4
34 Fibrinolytic Agents Phase 4
35 Platelet Aggregation Inhibitors Phase 4
36
Coumarin Experimental, Nutraceutical Phase 4 91-64-5 323
37
Bisoprolol Approved Phase 3 66722-44-9 2405
38
Selenium Approved, Investigational, Vet_approved Phase 3 7782-49-2
39
Amiodarone Approved, Investigational Phase 3,Not Applicable 1951-25-3 2157
40
Coal tar Approved Phase 3 8007-45-2
41 Melarsoprol Investigational Phase 3 494-79-1
42 Adrenergic beta-1 Receptor Antagonists Phase 3
43 Autonomic Agents Phase 3
44 Sympatholytics Phase 3
45 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Not Applicable
46 Antioxidants Phase 3
47 Micronutrients Phase 3
48 Protective Agents Phase 3
49 Sodium Selenite Phase 3
50 Trace Elements Phase 3

Interventional clinical trials:

(show top 50) (show all 76)
# Name Status NCT ID Phase Drugs
1 Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Phase Completed NCT00906880 Phase 4 Nifurtimox-Eflronithine Combination Treatment (NECT)
2 Population Pharmacokinetics in Benznidazole-treated Adults With Chronic With Chagas Disease Completed NCT01755403 Phase 4 Benznidazole
3 Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease Completed NCT01678599 Phase 4 Benznidazole
4 Population Pharmacokinetics Study of Benznidazole in Children With Chagas'Disease Completed NCT01549236 Phase 4 Benznidazole 12,5mg or 100mg
5 Exercise Training in Chagas Cardiomyopathy Completed NCT01006473 Phase 4
6 A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
7 Outcomes of an Anticoagulation Clinic in an University Hospital Completed NCT01006486 Phase 4
8 Clinical Assessment, Neuroimaging and Immunomarkers in Chagas Disease Study (CLINICS) Recruiting NCT01650792 Phase 4 Aspirin
9 Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease Terminated NCT01539161 Phase 4
10 BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Unknown status NCT00123916 Phase 3 Benznidazole;Placebo
11 Efficacy - Safety of Eflornithine-Nifurtimox Combination Versus Eflornithine to Treat Human African Trypanosomiasis Completed NCT00146627 Phase 3 Eflornithine;Nifurtimox
12 Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2 Completed NCT01685827 Phase 2, Phase 3 Fexinidazole;Nifurtimox;Eflornithine
13 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
14 Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial Completed NCT02386358 Phase 3 Benznidazole;Placebo
15 Physical Exercise Program in Chronic Chagas Heart Disease Completed NCT02517632 Phase 3
16 Cardiac Rehabilitation in Chagas Heart Failure Completed NCT02516293 Phase 2, Phase 3
17 Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Completed NCT00323973 Phase 3 Bisoprolol
18 Prospective Study on Efficacy and Safety of SCYX-7158 in Patients Infected by Human African Trypanosomiasis Due to T.b. Gambiense Recruiting NCT03087955 Phase 2, Phase 3 SCYX 7158
19 Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage Recruiting NCT03025789 Phase 3 Fexinidazole
20 CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) Recruiting NCT02369978 Phase 2, Phase 3 Nifurtimox;Benznidazole;Placebo
21 Selenium Treatment and Chagasic Cardiopathy (STCC) Recruiting NCT00875173 Phase 3 Selenium;Placebo (for Selenium)
22 A Trial Testing Amiodarone in Chagas Cardiomiopathy Recruiting NCT03193749 Phase 3 Amiodarone Hydrochloride;Placebo Oral Tablet
23 Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal Study Active, not recruiting NCT02169557 Phase 2, Phase 3 Fexinidazole
24 Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal Study Active, not recruiting NCT02184689 Phase 2, Phase 3 fexinidazole
25 Prospective Study of a Pediatric Nifurtimox Formulation for Chagas' Disease Active, not recruiting NCT02625974 Phase 3 Nifurtimox (BAYA2502);Nifurtimox (BAYA2502) followed by Placebo
26 Eflornithine + Nifurtimox Late-Stage Human African Trypanosomiasis (HAT)in West Nile, Uganda Terminated NCT00489658 Phase 2, Phase 3 Eflornithine plus Nifurtimox combination therapy
27 Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis Terminated NCT00330148 Phase 3 melarsoprol 1.8 mg/kg/d, 10d + nifurtimox 15/20 mg/kg/d, 10d;melarsoprol 1.8 mg/kg/d, 10d + eflornithine 400 mg/kg/d, 7d;nifurtimox 15/20 mg/kg/d 10d + eflornithine 400 mg/kg/d 7d
28 Cell Therapy in Chagas Cardiomyopathy Terminated NCT00349271 Phase 3 Filgrastime (G-CSF);Standart therapy
29 Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease Unknown status NCT02498782 Phase 2 Fexinidazole;Placebo
30 Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease Unknown status NCT01489228 Phase 2 E1224;Benznidazole;Placebo
31 Trial of DB289 for the Treatment of Stage I African Trypanosomiasis Completed NCT00803933 Phase 2 DB289;Pentamidine
32 A Trial of DB289 for the Treatment of Stage I African Trypanosomiasis Completed NCT00802594 Phase 2 DB289
33 A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) Completed NCT01377480 Phase 2 Posaconazole;Placebo for posaconazole;Benznidazole
34 Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole Completed NCT01162967 Phase 2 Benznidazole;Posaconazole
35 Evaluation of Different Benznidazole Regimens for the Treatment of Chronic Chagas Disease. Recruiting NCT03191162 Phase 2 Benznidazole
36 BENDITA BEnznidazole New Doses Improved Treatment and Associations Active, not recruiting NCT03378661 Phase 2 Benznidazole;E1224;E1224 Placebo;Benznidazole Placebo
37 Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy Enrolling by invitation NCT02154269 Phase 2 Treatment with G-CSF (Granulocyte colony stimulating factor);Placebo saline
38 Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the Fexinidazole Completed NCT00982904 Phase 1 Fexinidazole/Placebo
39 Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158 Completed NCT01533961 Phase 1 SCYX-7158;Placebo
40 Bioequivalence Study - Reference Clinical Fexinidazole Tablet Versus Proposed Market Formulation Completed NCT02571062 Phase 1 Fexinidazole
41 Fexinidazole (1200mg) Bioavailability Under Different Food Intake Conditions Completed NCT01340157 Phase 1 Fexinidazole
42 Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients Completed NCT02606864 Phase 1 Nifurtimox (BAYa2502)
43 Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients Completed NCT01927224 Phase 1 Nifurtimox (BAYa2502) (4 x 30 mg tablet);Nifurtimox (BAYa2502) (slurry of 4 x 30 mg tablets in tap water);Nifurtimox (BAYa2502) (120 mg tablet)
44 Study Will Evaluate the Relative Bioavailability, Safety, and Tolerability of Single Doses of Nifurtimox 30 mg Tablets Exhibiting Different in Vitro Dissolution Characteristics, and to Evaluate the Relative Bioavailability of Nifurtimox 30 mg and 120 mg Recruiting NCT03350295 Phase 1 Nifurtimox (Lampit, BAYA2502)
45 Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study Not yet recruiting NCT03334838 Phase 1 Nifurtimox (Lampit, BAYA2502)
46 Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food Terminated NCT01483170 Phase 1 Tablets Fexinidazole;Placebo
47 Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Unknown status NCT00453700 Not Applicable
48 Exercise Training in Patients With Chagasic Heart Disease Without Ventricular Dysfunction Unknown status NCT02295215 Not Applicable
49 Renal Denervation in Patients With Heart Failure Secondary to Chagas Disease Unknown status NCT02099903 Not Applicable
50 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable

Search NIH Clinical Center for Trypanosomiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: trypanosomiasis

Genetic Tests for Trypanosomiasis

Anatomical Context for Trypanosomiasis

MalaCards organs/tissues related to Trypanosomiasis:

41
Testes, Heart, Brain, T Cells, Endothelial, B Cells, Skin

Publications for Trypanosomiasis

Articles related to Trypanosomiasis:

(show top 50) (show all 682)
# Title Authors Year
1
Melarsoprol Resistance in African Trypanosomiasis. ( 29705579 )
2018
2
Integrated cost-benefit analysis of tsetse control and herd productivity to inform control programs for animal African trypanosomiasis. ( 29514668 )
2018
3
A case of delayed diagnosis of East-African trypanosomiasis in a Dutch traveller. ( 29688491 )
2018
4
No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations. ( 29470556 )
2018
5
Mortality trends and risk factors in advanced stage-2 Human African Trypanosomiasis: A critical appraisal of 23 years of experience in the Democratic Republic of Congo. ( 29897919 )
2018
6
African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System. ( 29497418 )
2018
7
Brain-penetrant, triazolopyrimidine and phenylpyrimidine microtubule-stabilizers as potential leads to treat human African trypanosomiasis. ( 29969537 )
2018
8
FDG PET/CT in a Case of Human African Trypanosomiasis (Sleeping Sickness). ( 29863573 )
2018
9
Trypanosomiasis in a Young Infant from Rural Gujarat, India. ( 29396940 )
2018
10
Oral fexinidazole for human African trypanosomiasis. ( 29353603 )
2018
11
The impact of passive case detection on the transmission dynamics of gambiense Human African Trypanosomiasis. ( 29624584 )
2018
12
A Phase III Diagnostic Accuracy Study of a Rapid Diagnostic Test for Diagnosis of Second-Stage Human African Trypanosomiasis in the Democratic Republic of the Congo. ( 29246478 )
2018
13
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT). ( 29169674 )
2018
14
Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis. ( 29744736 )
2018
15
Human African trypanosomiasis: How do the parasites enter and cause dysfunctions of the nervous system in murine models? ( 29870779 )
2018
16
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides. ( 29191556 )
2018
17
Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis. ( 29701144 )
2018
18
A multicentre, randomised, non-inferiority clinical trial comparing a nifurtimox-eflornithine combination to standard eflornithine monotherapy for late stage Trypanosoma brucei gambiense human African trypanosomiasis in Uganda. ( 29471865 )
2018
19
Human African Trypanosomiasis in Emigrant Returning to China from Gabon, 2017. ( 29350158 )
2018
20
Socioeconomic benefit to individuals of achieving 2020 targets for four neglected tropical diseases controlled/eliminated by innovative and intensified disease management: Human African trypanosomiasis, leprosy, visceral leishmaniasis, Chagas disease. ( 29534061 )
2018
21
A meta-analysis of the prevalence of African animal trypanosomiasis in Nigeria from 1960 to 2017. ( 29720251 )
2018
22
The development of high resolution maps of tsetse abundance to guide interventions against human African trypanosomiasis in northern Uganda. ( 29884213 )
2018
23
The structure of serum resistance-associated protein and its implications for human African trypanosomiasis. ( 29358741 )
2018
24
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial. ( 29113731 )
2018
25
Pastoralists' Vulnerability to Trypanosomiasis in Maasai Steppe. ( 29098491 )
2017
26
Bovine trypanosomiasis in tsetse-free pastoral zone of the Far-North region, Cameroon. ( 29097642 )
2017
27
Performance of the SD BIOLINEAr HAT rapid test in various diagnostic algorithms for gambiense human African trypanosomiasis in the Democratic Republic of the Congo. ( 28672036 )
2017
28
Sexual transmission of American trypanosomiasis in humans: a new potential pandemic route for Chagas parasites. ( 28591404 )
2017
29
Use of Zymography in Trypanosomiasis Studies. ( 28608214 )
2017
30
Human African trypanosomiasis control: Achievements and challenges. ( 28426685 )
2017
31
Case of Nigeria-Acquired Human African Trypanosomiasis in United Kingdom, 2016. ( 28628444 )
2017
32
Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. ( 28827791 )
2017
33
Delineating neuroinflammation, parasite CNS invasion, and blood-brain barrier dysfunction in an experimental murine model of human African trypanosomiasis. ( 28636879 )
2017
34
Dose-dependent effect and pharmacokinetics of fexinidazole and its metabolites in a mouse model of human African trypanosomiasis. ( 28552771 )
2017
35
The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of CA'te d'Ivoire identifies pigs and cattle as potential reservoirs of Trypanosoma brucei gambiense. ( 29045405 )
2017
36
Discovery and genomic analyses of hybridization between divergent lineages of Trypanosoma congolense, causative agent of Animal African Trypanosomiasis. ( 28752916 )
2017
37
Introducing the TrypanoGEN biobank: A valuable resource for the elimination of human African trypanosomiasis. ( 28570558 )
2017
38
Hsp70/J-protein machinery from Glossina morsitans morsitans, vector of African trypanosomiasis. ( 28902917 )
2017
39
Trypanosomiasis in an Australian little red flying fox (Pteropus scapulatus). ( 28653380 )
2017
40
Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis. ( 28821016 )
2017
41
Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis. ( 28074881 )
2017
42
People, Patches, and Parasites: The Case of Trypanosomiasis in Zimbabwe. ( 29170590 )
2017
43
Enhanced passive screening and diagnosis for gambiense human African trypanosomiasis in north-western Uganda - Moving towards elimination. ( 29023573 )
2017
44
Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis. ( 28713367 )
2017
45
Serological tests for gambiense human African trypanosomiasis detect antibodies in cattle. ( 29100526 )
2017
46
Vertical transmission of human African trypanosomiasis: Clinical evolution and brain MRI of a mother and her son. ( 28750004 )
2017
47
The challenging problem of disease staging in human African trypanosomiasis (sleeping sickness): a new approach to a circular question. ( 28957467 )
2017
48
Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in CA'te d'Ivoire. ( 29059176 )
2017
49
Impact of the Ebola outbreak on Trypanosoma brucei gambiense infection medical activities in coastal Guinea, 2014-2015: A retrospective analysis from the Guinean national Human African Trypanosomiasis control program. ( 29131822 )
2017
50
The socio-economic burden of human African trypanosomiasis and the coping strategies of households in the South Western Kenya foci. ( 29073144 )
2017

Variations for Trypanosomiasis

Expression for Trypanosomiasis

Search GEO for disease gene expression data for Trypanosomiasis.

Pathways for Trypanosomiasis

Pathways related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CALR CCL2 CCL3 CXCL8 HP IFNG
2
Show member pathways
13.77 CCL2 CCL3 CXCL8 IFNG IL10 IL1B
3
Show member pathways
13.63 CCL2 CCL3 CXCL8 IFNG IL10 IL1B
4
Show member pathways
13.54 CCL2 CCL3 CXCL8 IL10 IL1B IL2
5
Show member pathways
13.49 CCL2 CCL3 CXCL8 IFNG IL10 IL1B
6
Show member pathways
13.42 CCL2 CCL3 CXCL8 IL10 IL1B IL2
7
Show member pathways
13.07 CALR CCL2 CCL3 CXCL8 IFNG IL10
8
Show member pathways
13.02 CALR CXCL8 IFNG IL10 IL1B IL2
9
Show member pathways
12.93 CCL2 CXCL8 IFNG IL1B IL2 IL4
10
Show member pathways
12.89 IFNG IL1B IL2 IL4 TLR9 TNF
11 12.87 CXCL8 IFNG IL2 IL4 IL6
12
Show member pathways
12.81 CXCL8 IFNG IL1B IL6 TNF
13
Show member pathways
12.76 IL1B IL2 IL6 TLR9 TNF
14
Show member pathways
12.76 CXCL8 IFNG IL10 IL1B IL2 IL4
15
Show member pathways
12.75 CCL2 IFNG IL10 IL1B IL2 IL6
16 12.66 CCL2 IDO1 IFNG IL10 IL1B IL2
17
Show member pathways
12.6 IFNG IL10 IL1B IL2 IL4 IL6
18
Show member pathways
12.59 IFNG IL10 IL1B IL2 IL4 IL6
19
Show member pathways
12.48 CCL2 CXCL8 IFNG IL1B IL4 IL6
20 12.46 CALR IL2 IL6 TNF
21
Show member pathways
12.46 ALB CCL2 IFNG IL1B IL2 IL4
22
Show member pathways
12.41 CXCL8 IFNG IL1B IL6 TNF
23
Show member pathways
12.41 IFNG IL10 IL1B IL2 IL6 TLR9
24 12.39 IFNG IL10 IL1B IL6 TLR9 TNF
25
Show member pathways
12.38 IFNG IL10 IL1B IL4 TNF
26
Show member pathways
12.37 IL10 IL1B IL2 IL6 TLR9 TNF
27 12.33 CXCL8 IL10 IL1B IL6 TF TNF
28
Show member pathways
12.32 CXCL8 IL6 TLR9 TNF
29
Show member pathways
12.32 CXCL8 IFNG IL1B IL4 IL6 TLR9
30
Show member pathways
12.29 CXCL8 IL1B IL6 TNF
31 12.26 IFNG IL6 TLR9 TNF
32
Show member pathways
12.2 CCL2 CCL3 CXCL8 IFNG IL10 IL1B
33 12.18 CCL2 IFNG IL1B TNF
34 12.16 IFNG IL10 IL2 IL4 IL6 TNF
35
Show member pathways
12.14 CCL3 IFNG IL1B IL2 IL4
36 12.11 CCL3 CXCL8 IFNG IL1B IL6
37 12.11 CCL2 CXCL8 IL10 IL1B IL4 IL6
38
Show member pathways
12.1 ALB APOL1 CALR HP HPR
39 12.07 CCL2 CXCL8 IL1B IL6 TNF
40 12.06 CCL2 IL1B IL6 TNF
41 12.06 CXCL8 IFNG IL10 IL1B IL6 TNF
42 12.01 IL1B IL4 IL6 TNF
43 12 CCL3 CXCL8 IFNG IL1B IL6
44 12 CCL2 CXCL8 IFNG IL1B IL2 IL4
45 11.98 IFNG IL10 IL2 IL6
46 11.98 CXCL8 IFNG IL2 IL4 IL6
47 11.96 CCL2 CCL3 CXCL8 IFNG IL1B IL6
48
Show member pathways
11.93 CXCL8 IFNG IL2 IL4 TNF
49 11.93 CXCL8 IL10 IL1B IL6 TNF
50 11.88 CCL3 IFNG IL10 IL1B IL2 IL4

GO Terms for Trypanosomiasis

Cellular components related to Trypanosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 ALB APOL1 CALR CCL2 CCL3 CXCL8
2 endoplasmic reticulum lumen GO:0005788 9.65 ALB APOL1 CALR IL6 TF
3 blood microparticle GO:0072562 9.55 ALB APOL1 HP HPR TF
4 extracellular space GO:0005615 9.53 ALB APOL1 CALR CCL2 CCL3 CXCL8

Biological processes related to Trypanosomiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 receptor-mediated endocytosis GO:0006898 9.99 ALB APOL1 CALR HP HPR
2 positive regulation of protein phosphorylation GO:0001934 9.98 IFNG IL1B IL2 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 IL1B IL6 TLR9 TNF
4 positive regulation of gene expression GO:0010628 9.95 CALR CCL3 IFNG IL1B IL6 TLR9
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.93 IL10 IL1B IL6 TNF
6 inflammatory response GO:0006954 9.91 CCL2 CCL3 CXCL8 IDO1 IL10 IL1B
7 cellular response to interleukin-1 GO:0071347 9.9 CCL2 CCL3 CXCL8
8 positive regulation of inflammatory response GO:0050729 9.9 CCL3 IL2 TLR9
9 chemokine-mediated signaling pathway GO:0070098 9.9 CCL2 CCL3 CXCL8
10 positive regulation of JNK cascade GO:0046330 9.9 IL1B TLR9 TNF
11 regulation of insulin secretion GO:0050796 9.89 IFNG IL1B TNF
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.89 IFNG IL2 IL6
13 cellular response to lipopolysaccharide GO:0071222 9.89 CCL2 CXCL8 IL10 IL6 TNF
14 response to glucocorticoid GO:0051384 9.88 IL10 IL6 TNF
15 cellular response to organic cyclic compound GO:0071407 9.88 CCL2 CCL3 IL1B TNF
16 neutrophil chemotaxis GO:0030593 9.87 CCL2 CCL3 CXCL8 IL1B
17 positive regulation of T cell proliferation GO:0042102 9.86 IL1B IL2 IL4 IL6
18 monocyte chemotaxis GO:0002548 9.85 CCL2 CCL3 IL6
19 positive regulation of interferon-gamma production GO:0032729 9.85 IL1B IL2 TNF
20 immune response GO:0006955 9.85 CCL2 CCL3 CXCL8 IFNG IL10 IL1B
21 positive regulation of B cell proliferation GO:0030890 9.84 IL2 IL4 TLR9
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 IFNG IL1B TNF
23 humoral immune response GO:0006959 9.84 CCL2 IFNG IL6 TNF
24 response to organic substance GO:0010033 9.83 CALR HP HPR IL10 TNF
25 positive regulation of phagocytosis GO:0050766 9.82 CALR IL1B TNF
26 positive regulation of interleukin-6 production GO:0032755 9.81 IL1B IL6 TLR9 TNF
27 positive regulation of interleukin-8 production GO:0032757 9.8 IL1B TLR9 TNF
28 negative regulation of interleukin-6 production GO:0032715 9.79 IL10 TLR9 TNF
29 positive regulation of interleukin-12 production GO:0032735 9.78 IDO1 IFNG TLR9
30 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 CALR IL1B TLR9 TNF
31 positive regulation of chemokine production GO:0032722 9.77 IL6 TLR9 TNF
32 protein kinase B signaling GO:0043491 9.76 CCL2 CCL3 IL1B TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.75 IFNG IL1B TNF
34 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL2 IL6
35 PERK-mediated unfolded protein response GO:0036499 9.73 CCL2 CXCL8
36 polyamine biosynthetic process GO:0006596 9.73 AMD1 ODC1
37 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.73 IL1B TLR9
38 negative regulation of lipid storage GO:0010888 9.72 IL6 TNF
39 positive regulation of isotype switching to IgG isotypes GO:0048304 9.72 IL2 IL4
40 response to molecule of bacterial origin GO:0002237 9.72 CXCL8 IL10 TLR9
41 polyamine metabolic process GO:0006595 9.71 AMD1 ODC1
42 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
43 endothelial cell apoptotic process GO:0072577 9.7 IL10 TNF
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.7 IL10 IL4
45 regulation of establishment of endothelial barrier GO:1903140 9.7 IL1B TNF
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 IL1B TNF
47 negative regulation of cytokine secretion involved in immune response GO:0002740 9.69 IL10 TNF
48 type 2 immune response GO:0042092 9.69 IL10 IL4
49 negative regulation of interleukin-8 production GO:0032717 9.68 IL10 TLR9
50 astrocyte cell migration GO:0043615 9.68 CCL2 CCL3

Molecular functions related to Trypanosomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL10 IL2 IL4 IL6
2 chemokine activity GO:0008009 9.43 CCL2 CCL3 CXCL8
3 cytokine activity GO:0005125 9.32 CCL2 CCL3 CXCL8 IFNG IL10 IL1B
4 hemoglobin binding GO:0030492 8.96 HP HPR

Sources for Trypanosomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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51 NDF-RT
54 NINDS
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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