MCID: TSH001
MIFTS: 38

Tsh Producing Pituitary Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Tsh Producing Pituitary Tumor

MalaCards integrated aliases for Tsh Producing Pituitary Tumor:

Name: Tsh Producing Pituitary Tumor 12 15
Thyrotroph Adenoma 12 59 72
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma 59
Thyroid Stimulating Hormone-Producing Pituitary Tumor 72
Tsh Secreting Adenoma of the Pituitary 12
Tsh Secreting Tumor of Pituitary 12
Tsh-Secreting Pituitary Adenoma 59
Pituitary Thyrotrophic Adenoma 59
Tsh-Oma 59

Classifications:

Orphanet: 59  
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:6275
NCIt 50 C8011
ICD10 via Orphanet 34 D35.2
UMLS via Orphanet 73 C0346303
Orphanet 59 ORPHA91347
UMLS 72 C0346303 C2362538

Summaries for Tsh Producing Pituitary Tumor

MalaCards based summary : Tsh Producing Pituitary Tumor, also known as thyrotroph adenoma, is related to pituitary tumors and gigantism. An important gene associated with Tsh Producing Pituitary Tumor is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Peptide ligand-binding receptors and Growth hormone receptor signaling. The drugs Somatostatin and Octreotide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and heart, and related phenotypes are goiter and enlarged pituitary gland

Related Diseases for Tsh Producing Pituitary Tumor

Diseases related to Tsh Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 30.5 PRL GH1
2 gigantism 30.5 PRL GH1
3 acromegaly 30.4 SSTR1 PRL GH1
4 chromophobe adenoma 30.4 PRL GH1
5 hyperprolactinemia 30.3 PRL GH1
6 craniopharyngioma 30.2 PRL GH1
7 hypopituitarism 30.2 PRL GH1
8 pituitary hormone deficiency, combined, 2 29.9 TSHB PRL GH1
9 hyperthyroidism 29.9 PRL GH1
10 hypothyroidism 29.8 TSHB PRL GH1
11 pituitary adenoma, prolactin-secreting 27.6 SSTR3 SSTR1 PRL GH1 CDH23
12 pituitary adenoma 11.0
13 graves disease 1 10.4
14 goiter 10.4
15 graves' disease 10.4
16 multiple endocrine neoplasia, type i 10.3
17 thyroid hormone resistance, generalized, autosomal dominant 10.3
18 congestive heart failure 10.3
19 multiple endocrine neoplasia 10.3
20 hyperthyroxinemia 10.2
21 exophthalmos 10.2
22 diabetes insipidus 10.2
23 fibrous dysplasia 10.2 PRL GH1
24 fibrous dysplasia/mccune-albright syndrome 10.2 PRL GH1
25 leukemia, chronic lymphocytic 10.2
26 thrombocytopenic purpura, autoimmune 10.2
27 anemia, autoimmune hemolytic 10.2
28 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
29 paraganglioma 10.2
30 lymphocytic leukemia 10.2
31 diarrhea 10.2
32 amenorrhea 10.2
33 purpura 10.2
34 hemolytic anemia 10.2
35 evans' syndrome 10.2
36 leukemia, b-cell, chronic 10.2
37 rare tumor 10.2
38 mccune-albright syndrome 10.2 PRL GH1
39 adenohypophysitis 10.2 PRL GH1
40 hypothalamic disease 10.2 PRL GH1
41 pseudohypoparathyroidism, type ia 10.1 PRL GH1
42 empty sella syndrome 10.1 PRL GH1
43 hyperpituitarism 10.1 PRL GH1
44 functioning pituitary adenoma 10.1 PRL GH1
45 hypothyroidism, central, and testicular enlargement 10.1 TSHB PRL
46 tetrahydrobiopterin deficiency 10.1 PRL GH1
47 pituitary adenoma 1, multiple types 10.1 PRL GH1
48 thyroid gland disease 10.1 TSHB PRL
49 pituitary stalk interruption syndrome 10.1 PRL GH1
50 adenoma 10.1

Graphical network of the top 20 diseases related to Tsh Producing Pituitary Tumor:



Diseases related to Tsh Producing Pituitary Tumor

Symptoms & Phenotypes for Tsh Producing Pituitary Tumor

Human phenotypes related to Tsh Producing Pituitary Tumor:

59 32 (show top 50) (show all 67)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 goiter 59 32 hallmark (90%) Very frequent (99-80%) HP:0000853
2 enlarged pituitary gland 59 32 hallmark (90%) Very frequent (99-80%) HP:0012505
3 increased thyroid-stimulating hormone level 59 32 hallmark (90%) Very frequent (99-80%) HP:0002925
4 osteopenia 59 32 frequent (33%) Frequent (79-30%) HP:0000938
5 hyperhidrosis 59 32 frequent (33%) Frequent (79-30%) HP:0000975
6 tremor 59 32 frequent (33%) Frequent (79-30%) HP:0001337
7 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
8 vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002013
9 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
10 osteoporosis 59 32 frequent (33%) Frequent (79-30%) HP:0000939
11 pallor 59 32 frequent (33%) Frequent (79-30%) HP:0000980
12 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
13 progressive visual loss 59 32 frequent (33%) Frequent (79-30%) HP:0000529
14 hypogonadotrophic hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000044
15 easy fatigability 59 32 frequent (33%) Frequent (79-30%) HP:0003388
16 male hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000026
17 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
18 abnormality of the menstrual cycle 59 32 frequent (33%) Frequent (79-30%) HP:0000140
19 gynecomastia 59 32 frequent (33%) Frequent (79-30%) HP:0000771
20 secondary growth hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008240
21 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
22 decreased fertility in females 59 32 frequent (33%) Frequent (79-30%) HP:0000868
23 decreased fertility in males 59 32 frequent (33%) Frequent (79-30%) HP:0012041
24 female hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000134
25 adrenocorticotropin deficient adrenal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011735
26 adrenocorticotropic hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011748
27 decreased circulating acth level 59 32 frequent (33%) Frequent (79-30%) HP:0002920
28 palpitations 59 32 frequent (33%) Frequent (79-30%) HP:0001962
29 decreased female libido 59 32 frequent (33%) Frequent (79-30%) HP:0030018
30 abnormality of hair density 59 32 frequent (33%) Frequent (79-30%) HP:0011357
31 thyroid crisis 59 32 frequent (33%) Frequent (79-30%) HP:0011782
32 ptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000508
33 diplopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000651
34 hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0000822
35 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
36 blindness 59 32 occasional (7.5%) Occasional (29-5%) HP:0000618
37 delayed puberty 59 32 occasional (7.5%) Occasional (29-5%) HP:0000823
38 hypokalemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002900
39 congestive heart failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001635
40 increased circulating gonadotropin level 59 32 occasional (7.5%) Occasional (29-5%) HP:0000837
41 supraventricular arrhythmia 59 32 occasional (7.5%) Occasional (29-5%) HP:0005115
42 periodic hypokalemic paresis 59 32 occasional (7.5%) Occasional (29-5%) HP:0008153
43 vertigo 59 32 occasional (7.5%) Occasional (29-5%) HP:0002321
44 growth hormone excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000845
45 abnormal visual field test 59 32 occasional (7.5%) Occasional (29-5%) HP:0030588
46 infertility 59 32 occasional (7.5%) Occasional (29-5%) HP:0000789
47 pericardial effusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0001698
48 bitemporal hemianopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0030521
49 oculomotor nerve palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0012246
50 prolactin excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000870

Drugs & Therapeutics for Tsh Producing Pituitary Tumor

Drugs for Tsh Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
2
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441
3 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
4 Gastrointestinal Agents Phase 1
5 Radiopharmaceuticals Phase 1
6 Antineoplastic Agents, Hormonal Phase 1
7 Edotreotide Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Antineoplastons A10 and AS2-1 in Patients With Metastatic or Incurable Neuroendocrine Tumors Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
2 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
3 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671

Search NIH Clinical Center for Tsh Producing Pituitary Tumor

Genetic Tests for Tsh Producing Pituitary Tumor

Anatomical Context for Tsh Producing Pituitary Tumor

MalaCards organs/tissues related to Tsh Producing Pituitary Tumor:

41
Pituitary, Thyroid, Heart, Testes

Publications for Tsh Producing Pituitary Tumor

Articles related to Tsh Producing Pituitary Tumor:

(show all 23)
# Title Authors PMID Year
1
Rubinstein-Taybi Syndrome Associated with Pituitary Macroadenoma: A Case Report. 38
28503387 2017
2
Concomitant Graves hyperthyroidism with thyrotrophin-secreting pituitary adenoma. 38
20224487 2010
3
Modification of hormonal secretion in clinically silent pituitary adenomas. 38
18350381 2009
4
Loss of heterozygosity at the SS receptor type 5 locus in human GH- and TSH-secreting pituitary adenomas. 38
15762041 2004
5
Oncocytic transformation in pituitary adenomas: immunohistochemical analyses of 65 cases. 38
15214824 2004
6
A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism. 38
12714791 2003
7
Clinically and biochemically silent thyrotroph adenoma with oncocytic change. 38
11146605 2000
8
Primary hypothyroidism-associated TSH-secreting pituitary adenoma/hyperplasia presenting as a bleeding nasal mass and extremely elevated TSH level. 38
10435850 1999
9
Galanin gene expression in radiothyroidectomy-induced thyrotroph adenomas. 38
8760077 1996
10
Thyrotropin-producing pituitary adenoma discovered as a pituitary incidentaloma. 38
8774963 1995
11
Heterogeneity of human luteinizing hormone in pituitary tumor homogenates and cell incubates. 38
7560806 1995
12
Immunohistochemical expression of PIT-1 protein in pituitary glands of human GRF transgenic mice: its relationship with hormonal expressions. 38
7951487 1993
13
TSH producing pituitary tumor: biochemical diagnosis and long-term medical management with octreotide. 38
1612557 1992
14
Effect of a long-acting somatostatin analogue (SMS 201-995) on a growth hormone and thyroid stimulating hormone-producing pituitary tumor. 38
1867112 1991
15
Relationship between somatostatin and growth hormone messenger ribonucleic acid in human pituitary adenomas: an in-situ hybridization histochemistry study. 38
1973086 1990
16
Circadian and pulsatile TSH secretion under physiological and pathophysiological conditions. 38
2210627 1990
17
Somatostatin and Thyrotrophin-Releasing Hormone Response and Receptor Status of a Thyrotrophin-Secreting Pituitary Adenoma: Clinical and in vitro Studies. 38
19210422 1989
18
Long term treatment with the somatostatin analog SMS 201-995 in a patient with a thyrotropin- and growth hormone-secreting pituitary adenoma. 38
2895119 1988
19
[Clinical evaluation of highly sensitive thyroid stimulating hormone immunoradiometric assay (RIABEAD II) kit]. 38
3393703 1988
20
[Selective control of different hypophysial secretions by long-lasting pharmacodynamic agents. Analogs of somatostatin and LHRH and long-lasting bromocriptine]. 38
2904789 1988
21
Pituitary gonadotroph adenomas in old Sprague-Dawley rats. 38
3935810 1985
22
Hyperprolactinaemia, amenorrhoea and galactorrhoea due to a pituitary thyrotroph adenoma. 38
2411452 1985
23
[A case of TSH-producing pituitary tumor]. 38
4009015 1985

Variations for Tsh Producing Pituitary Tumor

Cosmic variations for Tsh Producing Pituitary Tumor:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM22623 MEN1 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 11:64805772-64805772 24

Expression for Tsh Producing Pituitary Tumor

Search GEO for disease gene expression data for Tsh Producing Pituitary Tumor.

Pathways for Tsh Producing Pituitary Tumor

GO Terms for Tsh Producing Pituitary Tumor

Cellular components related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 PRL GH1

Biological processes related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.48 SSTR3 SSTR1
2 forebrain development GO:0030900 9.46 SSTR3 SSTR1
3 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.43 SSTR3 SSTR1
4 response to nutrient levels GO:0031667 9.4 PRL GH1
5 cerebellum development GO:0021549 9.37 SSTR3 SSTR1
6 response to starvation GO:0042594 9.32 SSTR3 SSTR1
7 cellular response to estradiol stimulus GO:0071392 9.26 SSTR3 SSTR1
8 response to estradiol GO:0032355 9.19 GH1
9 positive regulation of JAK-STAT cascade GO:0046427 9.16 PRL GH1
10 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 PRL GH1
11 somatostatin signaling pathway GO:0038170 8.62 SSTR3 SSTR1

Molecular functions related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 TSHB PRL GH1
2 neuropeptide binding GO:0042923 9.26 SSTR3 SSTR1
3 somatostatin receptor activity GO:0004994 8.96 SSTR3 SSTR1
4 prolactin receptor binding GO:0005148 8.62 PRL GH1

Sources for Tsh Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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