MCID: TSH001
MIFTS: 43

Tsh Producing Pituitary Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Tsh Producing Pituitary Tumor

MalaCards integrated aliases for Tsh Producing Pituitary Tumor:

Name: Tsh Producing Pituitary Tumor 12 15
Thyrotroph Adenoma 12 58 71
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma 58
Thyroid Stimulating Hormone-Producing Pituitary Tumor 71
Tsh Secreting Adenoma of the Pituitary 12
Tsh Secreting Tumor of Pituitary 12
Tsh-Secreting Pituitary Adenoma 58
Pituitary Thyrotrophic Adenoma 58
Tsh-Oma 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


Summaries for Tsh Producing Pituitary Tumor

MalaCards based summary : Tsh Producing Pituitary Tumor, also known as thyrotroph adenoma, is related to chromophobe adenoma and gigantism. An important gene associated with Tsh Producing Pituitary Tumor is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Peptide ligand-binding receptors and Relaxin signaling pathway. The drugs Somatostatin and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and heart, and related phenotypes are goiter and enlarged pituitary gland

Related Diseases for Tsh Producing Pituitary Tumor

Diseases related to Tsh Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 chromophobe adenoma 30.6 PRL GH1
2 gigantism 30.6 PRL GH1
3 diabetes insipidus 30.3 PRL GH1
4 pituitary hormone deficiency, combined, 2 30.2 TSHB PRL GH1
5 pituitary tumors 30.2 SSTR5 PRL GH1
6 hypothyroidism 30.1 TSHB PRL GH1
7 hyperprolactinemia 30.1 PRL GH1
8 thyroiditis 30.1 TSHB PRL
9 pituitary adenoma 29.5 TSHB SSTR5 SSTR3 SSTR2 PRL GH1
10 adenoma 29.3 SSTR5 SSTR2 PRL GH1
11 acromegaly 28.9 SSTR5 SSTR4 SSTR2 SSTR1 PRL GH1
12 pituitary adenoma, prolactin-secreting 26.7 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 PRL
13 graves disease 1 10.4
14 goiter 10.4
15 graves' disease 10.4
16 multiple endocrine neoplasia, type i 10.3
17 thyroid hormone resistance, generalized, autosomal dominant 10.3
18 congestive heart failure 10.3
19 multiple endocrine neoplasia 10.3
20 fibrous dysplasia 10.2 PRL GH1
21 fibrous dysplasia/mccune-albright syndrome 10.2 PRL GH1
22 mccune-albright syndrome 10.2 PRL GH1
23 adenohypophysitis 10.2 PRL GH1
24 acth deficiency, isolated 10.2 TSHB PRL
25 tetrahydrobiopterin deficiency 10.2 PRL GH1
26 pituitary-dependent cushing's disease 10.2 PRL GH1
27 hyperthyroxinemia 10.2
28 exophthalmos 10.2
29 hypopituitarism 10.2
30 pituitary apoplexy 10.2 PRL GH1
31 pituitary stalk interruption syndrome 10.2 PRL GH1
32 leukemia, chronic lymphocytic 10.2
33 thrombocytopenic purpura, autoimmune 10.2
34 anemia, autoimmune hemolytic 10.2
35 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
36 paraganglioma 10.2
37 lymphocytic leukemia 10.2
38 diarrhea 10.2
39 amenorrhea 10.2
40 purpura 10.2
41 craniopharyngioma 10.2
42 hemolytic anemia 10.2
43 evans' syndrome 10.2
44 rare tumor 10.2
45 empty sella syndrome 10.1 PRL GH1
46 pseudohypoparathyroidism, type ia 10.1 PRL GH1
47 pituitary hypoplasia 10.1 PRL GH1
48 intracranial hypertension 10.1 SSTR1 PRL
49 intracranial hypertension, idiopathic 10.1 SSTR1 GH1
50 pituitary adenoma 1, multiple types 10.1 PRL GH1

Graphical network of the top 20 diseases related to Tsh Producing Pituitary Tumor:



Diseases related to Tsh Producing Pituitary Tumor

Symptoms & Phenotypes for Tsh Producing Pituitary Tumor

Human phenotypes related to Tsh Producing Pituitary Tumor:

58 31 (show top 50) (show all 68)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 goiter 58 31 hallmark (90%) Very frequent (99-80%) HP:0000853
2 enlarged pituitary gland 58 31 hallmark (90%) Very frequent (99-80%) HP:0012505
3 increased thyroid-stimulating hormone level 58 31 hallmark (90%) Very frequent (99-80%) HP:0002925
4 hyperhidrosis 58 31 frequent (33%) Frequent (79-30%) HP:0000975
5 tremor 58 31 frequent (33%) Frequent (79-30%) HP:0001337
6 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
7 osteopenia 58 31 frequent (33%) Frequent (79-30%) HP:0000938
8 vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002013
9 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
10 osteoporosis 58 31 frequent (33%) Frequent (79-30%) HP:0000939
11 pallor 58 31 frequent (33%) Frequent (79-30%) HP:0000980
12 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
13 progressive visual loss 58 31 frequent (33%) Frequent (79-30%) HP:0000529
14 hypogonadotrophic hypogonadism 58 31 frequent (33%) Frequent (79-30%) HP:0000044
15 easy fatigability 58 31 frequent (33%) Frequent (79-30%) HP:0003388
16 male hypogonadism 58 31 frequent (33%) Frequent (79-30%) HP:0000026
17 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
18 abnormality of the menstrual cycle 58 31 frequent (33%) Frequent (79-30%) HP:0000140
19 gynecomastia 58 31 frequent (33%) Frequent (79-30%) HP:0000771
20 secondary growth hormone deficiency 58 31 frequent (33%) Frequent (79-30%) HP:0008240
21 impotence 58 31 frequent (33%) Frequent (79-30%) HP:0000802
22 decreased fertility in females 58 31 frequent (33%) Frequent (79-30%) HP:0000868
23 decreased fertility in males 58 31 frequent (33%) Frequent (79-30%) HP:0012041
24 female hypogonadism 58 31 frequent (33%) Frequent (79-30%) HP:0000134
25 adrenocorticotropin deficient adrenal insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0011735
26 adrenocorticotropic hormone deficiency 58 31 frequent (33%) Frequent (79-30%) HP:0011748
27 decreased circulating acth level 58 31 frequent (33%) Frequent (79-30%) HP:0002920
28 palpitations 58 31 frequent (33%) Frequent (79-30%) HP:0001962
29 decreased female libido 58 31 frequent (33%) Frequent (79-30%) HP:0030018
30 abnormality of hair density 58 31 frequent (33%) Frequent (79-30%) HP:0011357
31 thyroid crisis 58 31 frequent (33%) Frequent (79-30%) HP:0011782
32 seizures 58 31 occasional (7.5%) Occasional (29-5%) HP:0001250
33 ptosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000508
34 diplopia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000651
35 hypertension 58 31 occasional (7.5%) Occasional (29-5%) HP:0000822
36 blindness 58 31 occasional (7.5%) Occasional (29-5%) HP:0000618
37 delayed puberty 58 31 occasional (7.5%) Occasional (29-5%) HP:0000823
38 hypokalemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002900
39 congestive heart failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001635
40 increased circulating gonadotropin level 58 31 occasional (7.5%) Occasional (29-5%) HP:0000837
41 supraventricular arrhythmia 58 31 occasional (7.5%) Occasional (29-5%) HP:0005115
42 periodic hypokalemic paresis 58 31 occasional (7.5%) Occasional (29-5%) HP:0008153
43 vertigo 58 31 occasional (7.5%) Occasional (29-5%) HP:0002321
44 growth hormone excess 58 31 occasional (7.5%) Occasional (29-5%) HP:0000845
45 infertility 58 31 occasional (7.5%) Occasional (29-5%) HP:0000789
46 abnormal visual field test 58 31 occasional (7.5%) Occasional (29-5%) HP:0030588
47 pericardial effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0001698
48 bitemporal hemianopia 58 31 occasional (7.5%) Occasional (29-5%) HP:0030521
49 oculomotor nerve palsy 58 31 occasional (7.5%) Occasional (29-5%) HP:0012246
50 cranial nerve vi palsy 58 31 occasional (7.5%) Occasional (29-5%) HP:0006897

Drugs & Therapeutics for Tsh Producing Pituitary Tumor

Drugs for Tsh Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 1 51110-01-1, 38916-34-6 53481605
2 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
3 Radiopharmaceuticals Phase 1
4 Edotreotide Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Antineoplastons A10 and AS2-1 in Patients With Metastatic or Incurable Neuroendocrine Tumors Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
2 A Phase I, Open-Label, Maximum Tolerated Single-Cycle and Four-Cycle Dose-Finding Study to Evaluation the Safety and Tolerability of 90Y-SMT 487 Administered by Intravenous Infusion to Subjects With Refractory Somatostatin-Receptor Positive Tumors Completed NCT00006368 Phase 1
3 Prospective Study on the Short-Term Adverse Effects From Gamma Knife Radiosurgery Completed NCT00255671

Search NIH Clinical Center for Tsh Producing Pituitary Tumor

Genetic Tests for Tsh Producing Pituitary Tumor

Anatomical Context for Tsh Producing Pituitary Tumor

MalaCards organs/tissues related to Tsh Producing Pituitary Tumor:

40
Pituitary, Thyroid, Heart, Testes, T Cells, Liver, Breast

Publications for Tsh Producing Pituitary Tumor

Articles related to Tsh Producing Pituitary Tumor:

(show all 23)
# Title Authors PMID Year
1
Rubinstein-Taybi Syndrome Associated with Pituitary Macroadenoma: A Case Report. 61
28503387 2017
2
Concomitant Graves hyperthyroidism with thyrotrophin-secreting pituitary adenoma. 61
20224487 2010
3
Modification of hormonal secretion in clinically silent pituitary adenomas. 61
18350381 2009
4
Loss of heterozygosity at the SS receptor type 5 locus in human GH- and TSH-secreting pituitary adenomas. 61
15762041 2004
5
Oncocytic transformation in pituitary adenomas: immunohistochemical analyses of 65 cases. 61
15214824 2004
6
A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism. 61
12714791 2003
7
Clinically and biochemically silent thyrotroph adenoma with oncocytic change. 61
11146605 2000
8
Primary hypothyroidism-associated TSH-secreting pituitary adenoma/hyperplasia presenting as a bleeding nasal mass and extremely elevated TSH level. 61
10435850 1999
9
Galanin gene expression in radiothyroidectomy-induced thyrotroph adenomas. 61
8760077 1996
10
Thyrotropin-producing pituitary adenoma discovered as a pituitary incidentaloma. 61
8774963 1995
11
Heterogeneity of human luteinizing hormone in pituitary tumor homogenates and cell incubates. 61
7560806 1995
12
Immunohistochemical expression of PIT-1 protein in pituitary glands of human GRF transgenic mice: its relationship with hormonal expressions. 61
7951487 1993
13
TSH producing pituitary tumor: biochemical diagnosis and long-term medical management with octreotide. 61
1612557 1992
14
Effect of a long-acting somatostatin analogue (SMS 201-995) on a growth hormone and thyroid stimulating hormone-producing pituitary tumor. 61
1867112 1991
15
Relationship between somatostatin and growth hormone messenger ribonucleic acid in human pituitary adenomas: an in-situ hybridization histochemistry study. 61
1973086 1990
16
Circadian and pulsatile TSH secretion under physiological and pathophysiological conditions. 61
2210627 1990
17
Somatostatin and Thyrotrophin-Releasing Hormone Response and Receptor Status of a Thyrotrophin-Secreting Pituitary Adenoma: Clinical and in vitro Studies. 61
19210422 1989
18
Long term treatment with the somatostatin analog SMS 201-995 in a patient with a thyrotropin- and growth hormone-secreting pituitary adenoma. 61
2895119 1988
19
[Clinical evaluation of highly sensitive thyroid stimulating hormone immunoradiometric assay (RIABEAD II) kit]. 61
3393703 1988
20
[Selective control of different hypophysial secretions by long-lasting pharmacodynamic agents. Analogs of somatostatin and LHRH and long-lasting bromocriptine]. 61
2904789 1988
21
Pituitary gonadotroph adenomas in old Sprague-Dawley rats. 61
3935810 1985
22
Hyperprolactinaemia, amenorrhoea and galactorrhoea due to a pituitary thyrotroph adenoma. 61
2411452 1985
23
[A case of TSH-producing pituitary tumor]. 61
4009015 1985

Variations for Tsh Producing Pituitary Tumor

Cosmic variations for Tsh Producing Pituitary Tumor:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM92072553 MEN1 pituitary,NS,adenoma,TSH c.1065-2A>G p.? 11:64805772-64805772 24
2 COSM100255374 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 11:64805772-64805772 24
3 COSM100204187 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 11:64805772-64805772 24
4 COSM92200375 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 11:64805772-64805772 24
5 COSM100173638 pituitary,NS,adenoma,TSH c.1065-2A>G p.? 11:64805772-64805772 24
6 COSM99575811 pituitary,NS,adenoma,TSH c.1065-2A>G p.? 11:64805772-64805772 24
7 COSM90429831 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 11:64805772-64805772 24
8 COSM99563837 pituitary,NS,adenoma,TSH c.1065-2A>G p.? 11:64805772-64805772 24
9 COSM100244198 pituitary,NS,adenoma,TSH c.945-2A>G p.? 11:64805772-64805772 24

Expression for Tsh Producing Pituitary Tumor

Search GEO for disease gene expression data for Tsh Producing Pituitary Tumor.

Pathways for Tsh Producing Pituitary Tumor

GO Terms for Tsh Producing Pituitary Tumor

Cellular components related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
2 endosome lumen GO:0031904 8.62 PRL GH1

Biological processes related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1 PRL
2 G protein-coupled receptor signaling pathway GO:0007186 9.95 TSHB SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
3 negative regulation of cell proliferation GO:0008285 9.77 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
4 cerebellum development GO:0021549 9.67 SSTR3 SSTR2 SSTR1
5 neuropeptide signaling pathway GO:0007218 9.65 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
6 forebrain development GO:0030900 9.62 SSTR4 SSTR3 SSTR2 SSTR1
7 response to starvation GO:0042594 9.61 SSTR3 SSTR2 SSTR1
8 cellular response to estradiol stimulus GO:0071392 9.58 SSTR3 SSTR2 SSTR1
9 response to nutrient levels GO:0031667 9.54 PRL GH1
10 positive regulation of JAK-STAT cascade GO:0046427 9.52 PRL GH1
11 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.51 PRL GH1
12 cellular response to glucocorticoid stimulus GO:0071385 9.46 SSTR5 SSTR4 SSTR3 SSTR2
13 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.35 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
14 somatostatin signaling pathway GO:0038170 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Molecular functions related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.72 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
2 peptide binding GO:0042277 9.55 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
3 hormone activity GO:0005179 9.54 TSHB PRL GH1
4 neuropeptide binding GO:0042923 9.35 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1
5 prolactin receptor binding GO:0005148 9.26 PRL GH1
6 somatostatin receptor activity GO:0004994 9.02 SSTR5 SSTR4 SSTR3 SSTR2 SSTR1

Sources for Tsh Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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