MCID: TSH001
MIFTS: 49

Tsh Producing Pituitary Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Tsh Producing Pituitary Tumor

MalaCards integrated aliases for Tsh Producing Pituitary Tumor:

Name: Tsh Producing Pituitary Tumor 12 15
Thyrotroph Adenoma 12 59 73
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma 59
Thyroid Stimulating Hormone-Producing Pituitary Tumor 73
Tsh Secreting Adenoma of the Pituitary 12
Tsh Secreting Tumor of Pituitary 12
Tsh-Secreting Pituitary Adenoma 59
Pituitary Thyrotrophic Adenoma 59
Tsh-Oma 59

Classifications:

Orphanet: 59  
Rare endocrine diseases


Summaries for Tsh Producing Pituitary Tumor

MalaCards based summary : Tsh Producing Pituitary Tumor, also known as thyrotroph adenoma, is related to hyperthyroidism and craniopharyngioma. An important gene associated with Tsh Producing Pituitary Tumor is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Peptide ligand-binding receptors. The drugs Octreotide and Radiopharmaceuticals have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and heart, and related phenotypes are ptosis and diplopia

Related Diseases for Tsh Producing Pituitary Tumor

Diseases related to Tsh Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 hyperthyroidism 30.6 GH1 PRL SST
2 craniopharyngioma 30.2 GH1 GNRH1 PRL
3 adenoma 30.2 GH1 POMC PRL SST
4 hypothyroidism 29.5 GH1 POMC PRL TSHB TTR
5 pituitary adenoma 10.8
6 fibrous dysplasia/mccune-albright syndrome 10.2 GH1 PRL
7 pseudohypoparathyroidism, type ia 10.2 GH1 PRL
8 prolactin producing pituitary tumor 10.2 PRL SST
9 non-functioning pituitary adenoma 10.2 GH1 SST
10 growth hormone secreting pituitary adenoma 10.2 PRL SST
11 spinocerebellar degeneration 10.2 PRL SST
12 tetrahydrobiopterin deficiency 10.2 GH1 PRL
13 graves' disease 10.2
14 leukemia, chronic lymphocytic 2 10.1
15 leukemia, chronic lymphocytic 10.1
16 smith-magenis syndrome 10.1
17 graves disease 1 10.1
18 leukemia 10.1
19 lymphocytic leukemia 10.1
20 cystadenoma 10.1
21 evans' syndrome 10.1
22 leukemia, b-cell, chronic 10.1
23 suprasellar meningioma 10.1 POMC TSHB
24 lymphocytic hypophysitis 10.1 GH1 POMC
25 bronchus adenoma 10.1 POMC SST
26 bronchial adenomas/carcinoids childhood 10.1 POMC SST
27 sheehan syndrome 10.1 POMC PRL
28 acidophil adenoma 10.1 POMC SST
29 acth-secreting pituitary adenoma 10.1 POMC PRL
30 hypoadrenalism 10.1 GH1 POMC
31 pituitary adenoma 1, multiple types 10.1 GH1 PRL SST
32 verbal auditory agnosia 10.1 POMC SLC17A5
33 pancreatic endocrine carcinoma 10.1 POMC SST
34 pituitary stalk interruption syndrome 10.1 GH1 PRL
35 mccune-albright syndrome 10.1 GH1 PRL SST
36 glucagonoma 10.1 GHRH SST
37 fibrous dysplasia 10.1 GH1 PRL SST
38 hypothyroidism, central, and testicular enlargement 10.1 PRL TSHB
39 isolated growth hormone deficiency, type ib 10.1 GH1 GHRH
40 hypogonadotropism 10.1 GNRH1 PRL
41 abducens nerve disease 10.1 POMC PRL
42 pancreatic cholera 10.1 GHRH SST
43 pelvic varices 10.1 GNRH1 PRL
44 carcinoid syndrome 10.1 GHRH SST
45 zollinger-ellison syndrome 10.1 GHRH SST
46 adenohypophysitis 10.1 GH1 POMC PRL
47 gigantism 10.1 GH1 GHRH PRL
48 ectopic cushing syndrome 10.1 POMC SST
49 aromatase deficiency 10.0 GH1 GNRH1
50 pituitary carcinoma 10.0 POMC PRL SST

Graphical network of the top 20 diseases related to Tsh Producing Pituitary Tumor:



Diseases related to Tsh Producing Pituitary Tumor

Symptoms & Phenotypes for Tsh Producing Pituitary Tumor

Human phenotypes related to Tsh Producing Pituitary Tumor:

59 32 (show top 50) (show all 68)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000508
2 diplopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000651
3 hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0000822
4 osteopenia 59 32 frequent (33%) Frequent (79-30%) HP:0000938
5 hyperhidrosis 59 32 frequent (33%) Frequent (79-30%) HP:0000975
6 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
7 tremor 59 32 frequent (33%) Frequent (79-30%) HP:0001337
8 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
9 blindness 59 32 occasional (7.5%) Occasional (29-5%) HP:0000618
10 delayed puberty 59 32 occasional (7.5%) Occasional (29-5%) HP:0000823
11 vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002013
12 hypokalemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002900
13 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
14 osteoporosis 59 32 frequent (33%) Frequent (79-30%) HP:0000939
15 pallor 59 32 frequent (33%) Frequent (79-30%) HP:0000980
16 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
17 congestive heart failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001635
18 progressive visual loss 59 32 frequent (33%) Frequent (79-30%) HP:0000529
19 increased circulating gonadotropin level 59 32 occasional (7.5%) Occasional (29-5%) HP:0000837
20 hypogonadotrophic hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000044
21 supraventricular arrhythmia 59 32 occasional (7.5%) Occasional (29-5%) HP:0005115
22 goiter 59 32 hallmark (90%) Very frequent (99-80%) HP:0000853
23 easy fatigability 59 32 frequent (33%) Frequent (79-30%) HP:0003388
24 periodic hypokalemic paresis 59 32 occasional (7.5%) Occasional (29-5%) HP:0008153
25 male hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000026
26 vertigo 59 32 occasional (7.5%) Occasional (29-5%) HP:0002321
27 growth hormone excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000845
28 abnormality of the menstrual cycle 59 32 frequent (33%) Frequent (79-30%) HP:0000140
29 gynecomastia 59 32 frequent (33%) Frequent (79-30%) HP:0000771
30 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
31 abnormal visual field test 59 32 occasional (7.5%) Occasional (29-5%) HP:0030588
32 infertility 59 32 occasional (7.5%) Occasional (29-5%) HP:0000789
33 secondary growth hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008240
34 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
35 decreased fertility in females 59 32 frequent (33%) Frequent (79-30%) HP:0000868
36 decreased fertility in males 59 32 frequent (33%) Frequent (79-30%) HP:0012041
37 female hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000134
38 adrenocorticotropin deficient adrenal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011735
39 adrenocorticotropic hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011748
40 decreased circulating acth level 59 32 frequent (33%) Frequent (79-30%) HP:0002920
41 bitemporal hemianopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0030521
42 oculomotor nerve palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0012246
43 prolactin excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000870
44 enlarged pituitary gland 59 32 hallmark (90%) Very frequent (99-80%) HP:0012505
45 cranial nerve vi palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0006897
46 pericardial effusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0001698
47 decreased female libido 59 32 frequent (33%) Frequent (79-30%) HP:0030018
48 ventricular arrhythmia 59 32 occasional (7.5%) Occasional (29-5%) HP:0004308
49 palpitations 59 32 frequent (33%) Frequent (79-30%) HP:0001962
50 sudden loss of visual acuity 59 32 occasional (7.5%) Occasional (29-5%) HP:0001117

MGI Mouse Phenotypes related to Tsh Producing Pituitary Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.81 CDH23 CREBBP GAL GHRH GNRH1 POMC
2 homeostasis/metabolism MP:0005376 9.65 CDH23 CREBBP GAL GHRH GNRH1 POMC
3 nervous system MP:0003631 9.28 CDH23 CREBBP GAL GHRH GNRH1 POMC

Drugs & Therapeutics for Tsh Producing Pituitary Tumor

Drugs for Tsh Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 383414 6400441
2 Radiopharmaceuticals Phase 3,Phase 1
3 Antineoplastic Agents, Hormonal Phase 3,Phase 1
4 Gastrointestinal Agents Phase 3,Phase 1
5 Edotreotide Phase 3,Phase 1
6 Hormones Phase 2,Phase 1
7
Somatostatin Approved, Investigational Phase 1 51110-01-1, 38916-34-6 53481605
8 Pancreatic Polypeptide Investigational Phase 1 59763-91-6

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
2 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
3 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
4 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Tsh Producing Pituitary Tumor

Genetic Tests for Tsh Producing Pituitary Tumor

Anatomical Context for Tsh Producing Pituitary Tumor

MalaCards organs/tissues related to Tsh Producing Pituitary Tumor:

41
Pituitary, Thyroid, Heart, Liver, Pancreas, Cortex, Adrenal Gland

Publications for Tsh Producing Pituitary Tumor

Articles related to Tsh Producing Pituitary Tumor:

# Title Authors Year
1
A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism. ( 12714791 )
2003
2
Clinically and biochemically silent thyrotroph adenoma with oncocytic change. ( 11146605 )
2000
3
TSH producing pituitary tumor: biochemical diagnosis and long-term medical management with octreotide. ( 1612557 )
1992
4
Hyperprolactinaemia, amenorrhoea and galactorrhoea due to a pituitary thyrotroph adenoma. ( 2411452 )
1985

Variations for Tsh Producing Pituitary Tumor

Cosmic variations for Tsh Producing Pituitary Tumor:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM22623 MEN1 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 11:64805772-64805772 19

Expression for Tsh Producing Pituitary Tumor

Search GEO for disease gene expression data for Tsh Producing Pituitary Tumor.

Pathways for Tsh Producing Pituitary Tumor

Pathways related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 CDH23 CREBBP GH1 GHRH GNRH1
2
Show member pathways
12.49 GAL GH1 GHRH GNRH1 POMC PRL
3
Show member pathways
12.24 CREBBP GH1 GHRH GNRH1
4
Show member pathways
11.84 GH1 POMC TSHB
5 11.71 GHRH POMC TSHB
6
Show member pathways
11.57 CREBBP GH1 GHRH GNRH1
7
Show member pathways
11.07 GH1 PRL
8 11.05 CREBBP POMC PRL
9 10.27 GNRH1 TSHB

GO Terms for Tsh Producing Pituitary Tumor

Cellular components related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 GAL GH1 GHRH GNRH1 POMC PRL
2 secretory granule GO:0030141 9.33 GAL POMC PRL
3 extracellular space GO:0005615 9.28 GAL GH1 GHRH GNRH1 POMC PRL
4 endosome lumen GO:0031904 9.26 GH1 PRL

Biological processes related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.73 GAL GHRH GNRH1 POMC SST TSHB
2 positive regulation of multicellular organism growth GO:0040018 9.48 GH1 GHRH
3 response to steroid hormone GO:0048545 9.46 GNRH1 SST
4 positive regulation of JAK-STAT cascade GO:0046427 9.43 GH1 PRL
5 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.4 GH1 PRL
6 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.37 GH1 GHRH
7 cell-cell signaling GO:0007267 9.35 GHRH GNRH1 POMC SST TSHB
8 ovulation cycle GO:0042698 9.32 GNRH1 PRL
9 regulation of signaling receptor activity GO:0010469 9.28 GAL GH1 GHRH GNRH1 POMC PRL
10 positive regulation of lactation GO:1903489 9.16 GHRH PRL

Molecular functions related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.28 GAL GH1 GHRH GNRH1 POMC PRL
2 neuropeptide hormone activity GO:0005184 9.16 GAL GHRH
3 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Tsh Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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