MCID: TSH001
MIFTS: 50

Tsh Producing Pituitary Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Tsh Producing Pituitary Tumor

MalaCards integrated aliases for Tsh Producing Pituitary Tumor:

Name: Tsh Producing Pituitary Tumor 12 15
Thyrotroph Adenoma 12 60 74
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma 60
Thyroid Stimulating Hormone-Producing Pituitary Tumor 74
Tsh Secreting Adenoma of the Pituitary 12
Tsh Secreting Tumor of Pituitary 12
Tsh-Secreting Pituitary Adenoma 60
Pituitary Thyrotrophic Adenoma 60
Tsh-Oma 60

Classifications:

Orphanet: 60  
Rare endocrine diseases


Summaries for Tsh Producing Pituitary Tumor

MalaCards based summary : Tsh Producing Pituitary Tumor, also known as thyrotroph adenoma, is related to hyperthyroidism and craniopharyngioma. An important gene associated with Tsh Producing Pituitary Tumor is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Octreotide and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and brain, and related phenotypes are goiter and enlarged pituitary gland

Related Diseases for Tsh Producing Pituitary Tumor

Diseases related to Tsh Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 hyperthyroidism 31.1 GH1 PRL SST
2 craniopharyngioma 30.4 GH1 GNRH1 PRL
3 adenoma 29.8 GH1 POMC PRL SST SSTR5
4 hypothyroidism 29.3 GH1 POMC PRL TSHB TTR
5 pituitary adenoma 10.9
6 fibrous dysplasia/mccune-albright syndrome 10.4 GH1 PRL
7 pseudohypoparathyroidism, type ia 10.4 GH1 PRL
8 non-functioning pituitary adenoma 10.4 GH1 SST
9 prolactin producing pituitary tumor 10.4 PRL SST
10 pituitary adenoma 1, multiple types 10.3 GH1 PRL SST
11 type c thymoma 10.3 SST SSTR2
12 fibrous dysplasia 10.3 GH1 PRL SST
13 mccune-albright syndrome 10.3 GH1 PRL SST
14 hypogonadotropism 10.2 GNRH1 PRL
15 glucagonoma 10.2 GHRH SST
16 central precocious puberty 10.2 GH1 GNRH1
17 growth hormone secreting pituitary adenoma 10.2 PRL SST SSTR2
18 gigantism 10.2 GH1 GHRH PRL
19 carcinoid tumors, intestinal 10.2 SST SSTR2
20 spinocerebellar degeneration 10.2 PRL SST
21 patulous eustachian tube 10.2
22 graves' disease 10.2
23 oncogenic osteomalacia 10.2 SSTR1 SSTR3 SSTR5
24 isolated growth hormone deficiency, type ii 10.2 GH1 GHRH SST
25 leukemia, chronic lymphocytic 2 10.2
26 leukemia, chronic lymphocytic 10.2
27 smith-magenis syndrome 10.2
28 graves disease 1 10.2
29 leukemia 10.2
30 lymphocytic leukemia 10.2
31 cystadenoma 10.2
32 evans' syndrome 10.2
33 leukemia, b-cell, chronic 10.2
34 pelvic varices 10.1 GNRH1 PRL
35 hormone producing pituitary cancer 10.1 SST SSTR2 SSTR5
36 multiple endocrine neoplasia, type i 10.1 GHRH PRL SST
37 pancreatic cholera 10.1 GHRH SST
38 marasmus 10.1 GH1 TTR
39 isolated growth hormone deficiency, type ib 10.1 GH1 GHRH
40 serotonin syndrome 10.1 GHRH SST SSTR1
41 kwashiorkor 10.1 SLC17A5 TTR
42 bronchus adenoma 10.1 POMC SST
43 bronchial adenomas/carcinoids childhood 10.1 POMC SST
44 acidophil adenoma 10.1 POMC SST
45 lymphocytic hypophysitis 10.1 GH1 POMC
46 verbal auditory agnosia 10.0 POMC SLC17A5
47 insulin-like growth factor i 10.0 GH1 GHRH PRL SST
48 suprasellar meningioma 10.0 POMC TSHB
49 sheehan syndrome 10.0 POMC PRL
50 adenohypophysitis 10.0 GH1 POMC PRL

Graphical network of the top 20 diseases related to Tsh Producing Pituitary Tumor:



Diseases related to Tsh Producing Pituitary Tumor

Symptoms & Phenotypes for Tsh Producing Pituitary Tumor

Human phenotypes related to Tsh Producing Pituitary Tumor:

60 33 (show top 50) (show all 68)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 goiter 60 33 hallmark (90%) Very frequent (99-80%) HP:0000853
2 enlarged pituitary gland 60 33 hallmark (90%) Very frequent (99-80%) HP:0012505
3 increased thyroid-stimulating hormone level 33 hallmark (90%) HP:0002925
4 osteopenia 60 33 frequent (33%) Frequent (79-30%) HP:0000938
5 hyperhidrosis 60 33 frequent (33%) Frequent (79-30%) HP:0000975
6 tremor 60 33 frequent (33%) Frequent (79-30%) HP:0001337
7 hypotension 60 33 frequent (33%) Frequent (79-30%) HP:0002615
8 vomiting 60 33 frequent (33%) Frequent (79-30%) HP:0002013
9 fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012378
10 osteoporosis 60 33 frequent (33%) Frequent (79-30%) HP:0000939
11 pallor 60 33 frequent (33%) Frequent (79-30%) HP:0000980
12 weight loss 60 33 frequent (33%) Frequent (79-30%) HP:0001824
13 progressive visual loss 60 33 frequent (33%) Frequent (79-30%) HP:0000529
14 hypogonadotrophic hypogonadism 60 33 frequent (33%) Frequent (79-30%) HP:0000044
15 easy fatigability 60 33 frequent (33%) Frequent (79-30%) HP:0003388
16 male hypogonadism 60 33 frequent (33%) Frequent (79-30%) HP:0000026
17 abnormality of the menstrual cycle 60 33 frequent (33%) Frequent (79-30%) HP:0000140
18 gynecomastia 60 33 frequent (33%) Frequent (79-30%) HP:0000771
19 headache 60 33 frequent (33%) Frequent (79-30%) HP:0002315
20 secondary growth hormone deficiency 60 33 frequent (33%) Frequent (79-30%) HP:0008240
21 impotence 60 33 frequent (33%) Frequent (79-30%) HP:0000802
22 decreased fertility in females 60 33 frequent (33%) Frequent (79-30%) HP:0000868
23 decreased fertility in males 60 33 frequent (33%) Frequent (79-30%) HP:0012041
24 female hypogonadism 60 33 frequent (33%) Frequent (79-30%) HP:0000134
25 adrenocorticotropin deficient adrenal insufficiency 60 33 frequent (33%) Frequent (79-30%) HP:0011735
26 adrenocorticotropic hormone deficiency 60 33 frequent (33%) Frequent (79-30%) HP:0011748
27 decreased circulating acth level 60 33 frequent (33%) Frequent (79-30%) HP:0002920
28 decreased female libido 60 33 frequent (33%) Frequent (79-30%) HP:0030018
29 palpitations 60 33 frequent (33%) Frequent (79-30%) HP:0001962
30 abnormality of hair density 60 33 frequent (33%) Frequent (79-30%) HP:0011357
31 thyroid crisis 60 33 frequent (33%) Frequent (79-30%) HP:0011782
32 ptosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000508
33 diplopia 60 33 occasional (7.5%) Occasional (29-5%) HP:0000651
34 hypertension 60 33 occasional (7.5%) Occasional (29-5%) HP:0000822
35 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
36 blindness 60 33 occasional (7.5%) Occasional (29-5%) HP:0000618
37 delayed puberty 60 33 occasional (7.5%) Occasional (29-5%) HP:0000823
38 hypokalemia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002900
39 congestive heart failure 60 33 occasional (7.5%) Occasional (29-5%) HP:0001635
40 increased circulating gonadotropin level 60 33 occasional (7.5%) Occasional (29-5%) HP:0000837
41 supraventricular arrhythmia 60 33 occasional (7.5%) Occasional (29-5%) HP:0005115
42 periodic hypokalemic paresis 60 33 occasional (7.5%) Occasional (29-5%) HP:0008153
43 vertigo 60 33 occasional (7.5%) Occasional (29-5%) HP:0002321
44 growth hormone excess 60 33 occasional (7.5%) Occasional (29-5%) HP:0000845
45 abnormal visual field test 60 33 occasional (7.5%) Occasional (29-5%) HP:0030588
46 infertility 60 33 occasional (7.5%) Occasional (29-5%) HP:0000789
47 bitemporal hemianopia 60 33 occasional (7.5%) Occasional (29-5%) HP:0030521
48 oculomotor nerve palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0012246
49 prolactin excess 60 33 occasional (7.5%) Occasional (29-5%) HP:0000870
50 cranial nerve vi palsy 60 33 occasional (7.5%) Occasional (29-5%) HP:0006897

GenomeRNAi Phenotypes related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

27 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.8 GH1 POMC SSTR2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.8 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.8 GH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.8 POMC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.8 GH1 SSTR2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.8 SSTR2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.8 GH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.8 SSTR2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.8 SSTR2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.8 GH1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.8 SSTR2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.8 SSTR2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.8 GH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.8 SSTR2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.8 GH1 SSTR2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.8 POMC
17 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.8 POMC
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.8 SSTR2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.8 GH1 SSTR2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.8 SSTR2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.8 SSTR2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.8 POMC
23 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.8 POMC SSTR2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.8 GH1

MGI Mouse Phenotypes related to Tsh Producing Pituitary Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 CDH23 CREBBP GAL POMC PRL SLC17A5
2 growth/size/body region MP:0005378 9.85 CDH23 CREBBP GAL GHRH GNRH1 POMC
3 homeostasis/metabolism MP:0005376 9.8 CDH23 CREBBP GAL GHRH GNRH1 POMC
4 nervous system MP:0003631 9.36 CDH23 CREBBP GAL GHRH GNRH1 POMC

Drugs & Therapeutics for Tsh Producing Pituitary Tumor

Drugs for Tsh Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 6400441 383414
2 Gastrointestinal Agents Phase 3,Phase 1
3 Antineoplastic Agents, Hormonal Phase 3,Phase 1
4 Radiopharmaceuticals Phase 3,Phase 1
5 Edotreotide Phase 3,Phase 1
6 Hormones Phase 2,Phase 1
7
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
8 Pancreatic Polypeptide Investigational Phase 1 59763-91-6

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
2 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
3 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
4 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Tsh Producing Pituitary Tumor

Genetic Tests for Tsh Producing Pituitary Tumor

Anatomical Context for Tsh Producing Pituitary Tumor

MalaCards organs/tissues related to Tsh Producing Pituitary Tumor:

42
Pituitary, Thyroid, Brain, Testes

Publications for Tsh Producing Pituitary Tumor

Articles related to Tsh Producing Pituitary Tumor:

# Title Authors Year
1
A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism. ( 12714791 )
2003
2
Clinically and biochemically silent thyrotroph adenoma with oncocytic change. ( 11146605 )
2000
3
TSH producing pituitary tumor: biochemical diagnosis and long-term medical management with octreotide. ( 1612557 )
1992
4
Hyperprolactinaemia, amenorrhoea and galactorrhoea due to a pituitary thyrotroph adenoma. ( 2411452 )
1985

Variations for Tsh Producing Pituitary Tumor

Cosmic variations for Tsh Producing Pituitary Tumor:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM22623 MEN1 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 11:64805772-64805772 0

Expression for Tsh Producing Pituitary Tumor

Search GEO for disease gene expression data for Tsh Producing Pituitary Tumor.

Pathways for Tsh Producing Pituitary Tumor

GO Terms for Tsh Producing Pituitary Tumor

Cellular components related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 GAL GH1 GHRH GNRH1 POMC PRL
2 extracellular space GO:0005615 9.28 GAL GH1 GHRH GNRH1 POMC PRL
3 endosome lumen GO:0031904 9.26 GH1 PRL
4 secretory granule GO:0030141 9.16 GAL POMC

Biological processes related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.92 GAL GNRH1 SST SSTR1 SSTR2 SSTR3
2 cell-cell signaling GO:0007267 9.91 GHRH GNRH1 POMC SST SSTR3 TSHB
3 regulation of signaling receptor activity GO:0010469 9.81 GAL GH1 GHRH GNRH1 POMC PRL
4 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.77 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
5 forebrain development GO:0030900 9.76 SSTR1 SSTR2 SSTR3 SSTR4
6 cerebellum development GO:0021549 9.71 SSTR1 SSTR2 SSTR3
7 cellular response to glucocorticoid stimulus GO:0071385 9.71 SSTR2 SSTR3 SSTR4 SSTR5
8 cellular response to estradiol stimulus GO:0071392 9.67 SSTR1 SSTR2 SSTR3
9 response to starvation GO:0042594 9.65 SSTR1 SSTR2 SSTR3
10 positive regulation of JAK-STAT cascade GO:0046427 9.58 GH1 PRL
11 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.58 GH1 PRL
12 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.57 GH1 GHRH
13 hormone-mediated apoptotic signaling pathway GO:0008628 9.52 SST SSTR3
14 positive regulation of lactation GO:1903489 9.51 GHRH PRL
15 neuropeptide signaling pathway GO:0007218 9.5 GAL POMC SSTR1 SSTR2 SSTR3 SSTR4
16 ovulation cycle GO:0042698 9.26 GNRH1
17 somatostatin signaling pathway GO:0038170 9.02 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
18 signal transduction GO:0007165 10.15 CREBBP GNRH1 POMC SSTR1 SSTR2 SSTR3
19 G protein-coupled receptor signaling pathway GO:0007186 10 GAL GHRH GNRH1 POMC SST SSTR1

Molecular functions related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.72 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
2 neuropeptide binding GO:0042923 9.55 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
3 neuropeptide hormone activity GO:0005184 9.37 GAL GHRH
4 somatostatin receptor activity GO:0004994 9.35 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
5 hormone activity GO:0005179 9.28 GAL GH1 GHRH GNRH1 POMC PRL
6 prolactin receptor binding GO:0005148 9.26 GH1 PRL

Sources for Tsh Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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