MCID: TSH001
MIFTS: 42

Tsh Producing Pituitary Tumor

Categories: Endocrine diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Tsh Producing Pituitary Tumor

MalaCards integrated aliases for Tsh Producing Pituitary Tumor:

Name: Tsh Producing Pituitary Tumor 12 15
Thyrotroph Adenoma 12 59 73
Thyroid Stimulating Hormone-Secreting Pituitary Adenoma 59
Thyroid Stimulating Hormone-Producing Pituitary Tumor 73
Tsh Secreting Adenoma of the Pituitary 12
Tsh Secreting Tumor of Pituitary 12
Tsh-Secreting Pituitary Adenoma 59
Pituitary Thyrotrophic Adenoma 59
Tsh-Oma 59

Classifications:

Orphanet: 59  
Rare endocrine diseases


Summaries for Tsh Producing Pituitary Tumor

MalaCards based summary : Tsh Producing Pituitary Tumor, also known as thyrotroph adenoma, is related to pituitary tumors and hypothyroidism. An important gene associated with Tsh Producing Pituitary Tumor is CDH23 (Cadherin Related 23), and among its related pathways/superpathways are Peptide ligand-binding receptors and Peptide hormone metabolism. The drugs Octreotide and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and heart, and related phenotypes are male hypogonadism and hypogonadotrophic hypogonadism

Related Diseases for Tsh Producing Pituitary Tumor

Diseases related to Tsh Producing Pituitary Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 pituitary tumors 29.3 GH1 PRL SST
2 hypothyroidism 29.0 GH1 PRL TSHB
3 adenoma 29.0 GH1 PRL SST
4 pituitary adenoma 10.7
5 pituitary infarct 10.2 PRL SST
6 chiasmal syndrome 10.1 PRL SST
7 pituitary carcinoma 10.1 PRL SST
8 prolactin producing pituitary tumor 10.1 PRL SST
9 nelson syndrome 10.1 PRL SST
10 growth hormone secreting pituitary adenoma 10.1 PRL SST
11 adrenal cortex disease 10.1 PRL SST
12 fibrous dysplasia/mccune-albright syndrome 10.1 GH1 PRL
13 thyroid gland disease 10.1 PRL TSHB
14 adrenal gland disease 10.1 PRL SST
15 non-functioning pituitary adenoma 10.0 GH1 SST
16 adenohypophysitis 10.0 GH1 PRL
17 graves' disease 10.0
18 pseudohypoparathyroidism, type ia 10.0 GH1 PRL
19 hypothalamic disease 10.0 GH1 PRL
20 pituitary-dependent cushing's disease 10.0 PRL SST
21 gigantism 10.0 GH1 PRL
22 endocrine organ benign neoplasm 10.0 PRL SST
23 empty sella syndrome 10.0 GH1 PRL
24 organ system benign neoplasm 10.0 PRL SST
25 tetrahydrobiopterin deficiency 10.0 GH1 PRL
26 cell type benign neoplasm 9.9 PRL SST
27 chromophobe adenoma 9.9 GH1 PRL
28 pituitary stalk interruption syndrome 9.9 GH1 PRL
29 acquired metabolic disease 9.8 PRL SST
30 craniopharyngioma 9.8 GH1 PRL
31 multiple endocrine neoplasia, type i 9.8 PRL SST
32 hypopituitarism 9.8 GH1 PRL
33 insulin-like growth factor i 9.6 GH1 PRL
34 hypothyroidism, congenital, nongoitrous, 4 9.6 GH1 PRL TSHB
35 pituitary hormone deficiency, combined, 2 9.5 GH1 PRL TSHB
36 pituitary adenoma 1, multiple types 9.5 GH1 PRL SST
37 hyperpituitarism 9.5 GH1 PRL SST
38 functioning pituitary adenoma 9.5 GH1 PRL SST
39 mccune-albright syndrome 9.5 GH1 PRL SST
40 fibrous dysplasia 9.5 GH1 PRL SST
41 hyperinsulinism 9.5 GH1 SST
42 adrenal gland hyperfunction 9.5 GH1 PRL SST
43 pituitary gland disease 9.5 GH1 PRL SST
44 hyperprolactinemia 9.5 GH1 PRL SST
45 acromegaly 9.4 GH1 PRL SST
46 hyperthyroidism 9.4 GH1 PRL SST
47 anorexia nervosa 9.2 GH1 PRL
48 pituitary adenoma, prolactin-secreting 8.5 CDH23 GH1 PRL SST

Graphical network of the top 20 diseases related to Tsh Producing Pituitary Tumor:



Diseases related to Tsh Producing Pituitary Tumor

Symptoms & Phenotypes for Tsh Producing Pituitary Tumor

Human phenotypes related to Tsh Producing Pituitary Tumor:

59 32 (show top 50) (show all 68)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 male hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000026
2 hypogonadotrophic hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000044
3 female hypogonadism 59 32 frequent (33%) Frequent (79-30%) HP:0000134
4 abnormality of the menstrual cycle 59 32 frequent (33%) Frequent (79-30%) HP:0000140
5 ptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000508
6 progressive visual loss 59 32 frequent (33%) Frequent (79-30%) HP:0000529
7 blindness 59 32 occasional (7.5%) Occasional (29-5%) HP:0000618
8 diplopia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000651
9 gynecomastia 59 32 frequent (33%) Frequent (79-30%) HP:0000771
10 infertility 59 32 occasional (7.5%) Occasional (29-5%) HP:0000789
11 impotence 59 32 frequent (33%) Frequent (79-30%) HP:0000802
12 hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0000822
13 delayed puberty 59 32 occasional (7.5%) Occasional (29-5%) HP:0000823
14 increased circulating gonadotropin level 59 32 occasional (7.5%) Occasional (29-5%) HP:0000837
15 growth hormone excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000845
16 decreased fertility in females 59 32 frequent (33%) Frequent (79-30%) HP:0000868
17 goiter 59 32 hallmark (90%) Very frequent (99-80%) HP:0000853
18 prolactin excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000870
19 osteopenia 59 32 frequent (33%) Frequent (79-30%) HP:0000938
20 osteoporosis 59 32 frequent (33%) Frequent (79-30%) HP:0000939
21 hyperhidrosis 59 32 frequent (33%) Frequent (79-30%) HP:0000975
22 pallor 59 32 frequent (33%) Frequent (79-30%) HP:0000980
23 sudden loss of visual acuity 59 32 occasional (7.5%) Occasional (29-5%) HP:0001117
24 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
25 tremor 59 32 frequent (33%) Frequent (79-30%) HP:0001337
26 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
27 congestive heart failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001635
28 pericardial effusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0001698
29 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
30 palpitations 59 32 frequent (33%) Frequent (79-30%) HP:0001962
31 vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002013
32 vertigo 59 32 occasional (7.5%) Occasional (29-5%) HP:0002321
33 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
34 hypokalemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002900
35 decreased circulating acth level 59 32 frequent (33%) Frequent (79-30%) HP:0002920
36 easy fatigability 59 32 frequent (33%) Frequent (79-30%) HP:0003388
37 ventricular arrhythmia 59 32 occasional (7.5%) Occasional (29-5%) HP:0004308
38 supraventricular arrhythmia 59 32 occasional (7.5%) Occasional (29-5%) HP:0005115
39 cranial nerve vi palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0006897
40 fourth cranial nerve palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0007011
41 internal ophthalmoplegia 59 32 occasional (7.5%) Occasional (29-5%) HP:0007942
42 periodic hypokalemic paresis 59 32 occasional (7.5%) Occasional (29-5%) HP:0008153
43 euthyroid hyperthyroxinemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0008247
44 secondary growth hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0008240
45 abnormality of hair density 59 32 frequent (33%) Frequent (79-30%) HP:0011357
46 adrenocorticotropin deficient adrenal insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011735
47 adrenocorticotropic hormone deficiency 59 32 frequent (33%) Frequent (79-30%) HP:0011748
48 thyroid crisis 59 32 frequent (33%) Frequent (79-30%) HP:0011782
49 decreased fertility in males 59 32 frequent (33%) Frequent (79-30%) HP:0012041
50 oculomotor nerve palsy 59 32 occasional (7.5%) Occasional (29-5%) HP:0012246

Drugs & Therapeutics for Tsh Producing Pituitary Tumor

Drugs for Tsh Producing Pituitary Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 383414 6400441
2 Gastrointestinal Agents Phase 3,Phase 1
3 Edotreotide Phase 3,Phase 1
4 Radiopharmaceuticals Phase 3,Phase 1
5 Antineoplastic Agents, Hormonal Phase 3,Phase 1
6 Hormones Phase 2,Phase 1
7
Somatostatin Approved, Investigational Phase 1 38916-34-6, 51110-01-1 53481605
8 Pancreatic Polypeptide Investigational Phase 1 59763-91-6

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
2 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
3 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
4 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671

Search NIH Clinical Center for Tsh Producing Pituitary Tumor

Genetic Tests for Tsh Producing Pituitary Tumor

Anatomical Context for Tsh Producing Pituitary Tumor

MalaCards organs/tissues related to Tsh Producing Pituitary Tumor:

41
Pituitary, Thyroid, Heart, Testes, Brain

Publications for Tsh Producing Pituitary Tumor

Articles related to Tsh Producing Pituitary Tumor:

# Title Authors Year
1
A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism. ( 12714791 )
2003
2
Galanin gene expression in radiothyroidectomy-induced thyrotroph adenomas. ( 8760077 )
1996
3
TSH producing pituitary tumor: biochemical diagnosis and long-term medical management with octreotide. ( 1612557 )
1992

Variations for Tsh Producing Pituitary Tumor

Cosmic variations for Tsh Producing Pituitary Tumor:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM22623 MEN1 pituitary,NS,adenoma,TSH c.1050-2A>G p.? 11:64805772-64805772 19

Expression for Tsh Producing Pituitary Tumor

Search GEO for disease gene expression data for Tsh Producing Pituitary Tumor.

Pathways for Tsh Producing Pituitary Tumor

GO Terms for Tsh Producing Pituitary Tumor

Cellular components related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.46 GH1 PRL SST TSHB
2 extracellular space GO:0005615 9.26 GH1 PRL SST TSHB
3 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.26 GH1 PRL
2 positive regulation of JAK-STAT cascade GO:0046427 9.16 GH1 PRL
3 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 GH1 PRL
4 regulation of signaling receptor activity GO:0010469 8.92 GH1 PRL SST TSHB

Molecular functions related to Tsh Producing Pituitary Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 prolactin receptor binding GO:0005148 8.96 GH1 PRL
2 hormone activity GO:0005179 8.92 GH1 PRL SST TSHB

Sources for Tsh Producing Pituitary Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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