MCID: TBR006
MIFTS: 44

Tuberculoid Leprosy

Categories: Endocrine diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Tuberculoid Leprosy

MalaCards integrated aliases for Tuberculoid Leprosy:

Name: Tuberculoid Leprosy 12 15 17 70 32
Leprosy, Tuberculoid 44
Leprosy Tuberculoid 54
Smooth Leprosy 12
Type T Leprosy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1025
ICD9CM 34 030.1
MeSH 44 D015441
SNOMED-CT 67 70143003
ICD10 32 A30.1
UMLS 70 C0023351

Summaries for Tuberculoid Leprosy

Disease Ontology : 12 A leprosy that results in one erythematous large plaque with well-defined borders that are elevated and that slope down into an atrophic center.

MalaCards based summary : Tuberculoid Leprosy, also known as leprosy, tuberculoid, is related to neuritis and epidermodysplasia verruciformis 1. An important gene associated with Tuberculoid Leprosy is IFNG (Interferon Gamma), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, t cells and lymph node, and related phenotypes are cellular and cardiovascular system

Wikipedia : 73 Tuberculoid leprosy is a form of leprosy characterized by solitary skin lesions that are asymmetrically... more...

Related Diseases for Tuberculoid Leprosy

Diseases related to Tuberculoid Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 555)
# Related Disease Score Top Affiliating Genes
1 neuritis 30.7 TNF TGFB1 IL10 IFNG
2 epidermodysplasia verruciformis 1 30.2 CORO1A CD4 CCR6
3 erythema nodosum 30.2 TNF IL10 IFNG
4 syphilis 30.2 TNF IFNG CD4 CCR6
5 purpura 30.2 TNF IL10 IFNG
6 lepromatous leprosy 30.1 TNF TLR2 IL2 IL10 IFNG
7 iridocyclitis 30.1 TNF IL10 CD4
8 sporotrichosis 30.1 IL10 IFNG CD4
9 cheilitis 30.0 TNF CD4 CCR6
10 granuloma annulare 30.0 TNF CD4 CD1B
11 cytomegalovirus retinitis 29.9 TNF IL10 IFNG CD4
12 histoplasmosis 29.9 TNF IFNG CD4 CCR6
13 lymphopenia 29.7 IL2RA IL2 IL10 IFNG CORO1A
14 mycosis fungoides 29.7 IL2RA IL2 IFNG CCR6
15 sarcoidosis 1 29.7 TNF IL2RA IL2 IFNG CD4 CCR6
16 human immunodeficiency virus type 1 29.6 TNF IL2 IL10 IFNG CD4
17 myocarditis 29.6 TNF IL2 IL10 IFNG
18 cutaneous leishmaniasis 29.5 TNF TLR2 IL2 IL10 IFNG
19 leishmaniasis 29.5 TNF TLR2 TGFB1 IL2 IL10 IFNG
20 skin sarcoidosis 29.4 TNF IL2 IFNG CD4 CD1B
21 ulcerative colitis 29.3 TNF IL2 IL10 IFNG CCR6
22 alopecia areata 29.3 TNF IL2RA IL2 IL10 IFNG
23 tetanus 29.3 TNF IL2RA IL2 IL10 IFNG
24 severe combined immunodeficiency 29.3 IL2RA IL2 IL10 IFNG CORO1A
25 allergic contact dermatitis 29.3 TNF IL2RA IL10 IFNG CD4 CCR6
26 leprosy 3 29.3 TNF TLR2 SDHD LILRA2 IL2 IL10
27 mucocutaneous leishmaniasis 29.2 TNF IL2 IL10 IFNG CD4
28 allergic disease 29.2 TNF TLR2 IL2 IL10 IFNG CCR6
29 pulmonary tuberculosis 29.2 TNF TLR2 IL2RA IL2 IL10 IFNG
30 exanthem 29.2 TNF IL2 IL10 IFNG CD4 CCR6
31 paracoccidioidomycosis 29.2 TNF TLR2 IL2 IL10 IFNG
32 uveitis 29.1 TNF TGFB2 IL2RA IL2 IL10 IFNG
33 toxic shock syndrome 29.1 TNF TLR2 IL2 IL10 IFNG
34 psoriatic arthritis 29.1 TNF TLR2 IL2 IL10 IFNG
35 bacterial infectious disease 29.1 TNF TLR2 IL10 IFNG CD4 CCR6
36 disease by infectious agent 28.9 TNF TLR2 IL2 IL10 IFNG CD4
37 common variable immunodeficiency 28.8 TNF TLR2 IL2RA IL2 IL10 IFNG
38 combined immunodeficiency 28.7 TNF IL2RA IL2 IL10 IFNG CORO1A
39 mycobacterium tuberculosis 1 28.7 TNF TLR2 IL10 IFNG CD4 CD1B
40 chagas disease 28.5 TNF TLR2 TGFB1 IL2 IL10 IFNG
41 immune deficiency disease 28.5 TNF TLR2 IL2RA IL2 IL10 IFNG
42 contact dermatitis 28.5 TNF TLR2 IL2 IL10 IFNG CD4
43 dermatitis 28.5 TNF TLR2 IL2 IL10 IFNG CD4
44 colitis 28.4 TNF TLR2 IL2 IL10 IFNG CD4
45 systemic lupus erythematosus 28.4 TNF TLR2 TGFB1 IL2RA IL2 IL10
46 hypertension, essential 28.3 TNF TLR2 TGFB1 IL2 IL10 IFNG
47 dermatitis, atopic 28.2 TNF TLR2 IL2RA IL2 IL10 IFNG
48 asthma 27.7 TNF TLR2 TGFB1 IL2RA IL2 IL10
49 malaria 27.7 TNF TLR2 TGFB2 TGFB1 IL2RA IL2
50 hansen's disease 11.2

Graphical network of the top 20 diseases related to Tuberculoid Leprosy:



Diseases related to Tuberculoid Leprosy

Symptoms & Phenotypes for Tuberculoid Leprosy

MGI Mouse Phenotypes related to Tuberculoid Leprosy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 CD4 CORO1A IFNG IL10 IL2 SDHD
2 cardiovascular system MP:0005385 10.18 IFNG IL10 IL2 IL2RA SDHD TGFB1
3 growth/size/body region MP:0005378 10.15 BMP6 CD4 IFNG IL10 IL2 IL2RA
4 endocrine/exocrine gland MP:0005379 10.14 CD4 CORO1A IFNG IL10 IL2 IL2RA
5 digestive/alimentary MP:0005381 10.13 CD4 IFNG IL10 IL2 IL2RA TGFB1
6 hematopoietic system MP:0005397 10.13 CCR6 CD4 CORO1A IFNG IL10 IL2
7 immune system MP:0005387 10.03 CCR6 CD4 CORO1A IFNG IL10 IL2
8 neoplasm MP:0002006 9.7 IFNG IL10 IL2 SDHD TGFB1 TLR2
9 respiratory system MP:0005388 9.61 IFNG IL10 IL2 IL2RA TGFB1 TGFB2
10 skeleton MP:0005390 9.28 BMP6 IFNG IL10 IL2RA TGFB1 TGFB2

Drugs & Therapeutics for Tuberculoid Leprosy

Search Clinical Trials , NIH Clinical Center for Tuberculoid Leprosy

Cochrane evidence based reviews: leprosy, tuberculoid

Genetic Tests for Tuberculoid Leprosy

Anatomical Context for Tuberculoid Leprosy

MalaCards organs/tissues related to Tuberculoid Leprosy:

40
Skin, T Cells, Lymph Node, Thymus, Liver, Heart, Kidney

Publications for Tuberculoid Leprosy

Articles related to Tuberculoid Leprosy:

(show top 50) (show all 919)
# Title Authors PMID Year
1
Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens. 54 61
12798309 2003
2
Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns. 61 54
11698444 2001
3
Dysregulation of IL-4 expression in lepromatous leprosy patients with and without erythema nodosum leprosum. 54 61
11201870 2000
4
A postgenomic approach to identification of Mycobacterium leprae-specific peptides as T-cell reagents. 61 54
10992494 2000
5
Immunological cytokine correlates of protective immunity and pathogenesis in leprosy. 61 54
10736116 2000
6
Cytokines in leprosy, I. Serum cytokine profile in leprosy. 54 61
9802682 1998
7
Induction of Th1 cytokine responses by mycobacterial antigens in leprosy. 61 54
8926118 1996
8
Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy. 61 54
8719110 1995
9
CD26 expression in leprosy and other granulomatous diseases correlates with the production of interferon-gamma. 61 54
7474942 1995
10
Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. 61 54
7590888 1995
11
Mycobacterium leprae DNA content, cellular and cytokine patterns in skin lesions of leprosy patients undergoing multidrug therapy (MDT). 54 61
7713552 1994
12
Th1-Th2 paradigm: insights from leprosy. 61 54
8006444 1994
13
Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients. 54 61
8482851 1993
14
Lymphocyte proliferation, IFN-gamma production and limiting dilution analysis of T-cell responses to ICRC and Mycobacterium leprae antigens in leprosy patients. 54 61
8326181 1993
15
Immunohistologic assessment of cytokine production of infiltrating cells in various forms of leprosy. 54 61
2121040 1990
16
Restoration of defective cytokine activity within lepromatous leprosy lesions. 54 61
1972881 1990
17
Laser evoked potentials in the evaluation of hypoesthetic patches in tuberculoid leprosy. 61
33450576 2021
18
Borderline Tuberculoid Leprosy in Erythema Nodosum Leprosum Reaction Mimicking Sweet's Syndrome. 61
32861672 2021
19
[Association of borderline tuberculoid leprosy and tuberculosis: A case report and review of the literature]. 61
33127165 2020
20
A neglected illness still present nowadays: Tuberculoid leprosy. 61
31813644 2020
21
Clinico-pathological spectrum of cutaneous sarcoidosis: an experience from a government institute in North India. 61
32832888 2020
22
Role of Histopathology in Predicting type 1 Lepra Reaction in Borderline Tuberculoid Leprosy. 61
32832447 2020
23
Immune Complex-Driven Generation of Human Macrophages with Anti-Inflammatory and Growth-Promoting Activity. 61
32434940 2020
24
ER Stress Regulates Immunosuppressive Function of Myeloid Derived Suppressor Cells in Leprosy that Can Be Overcome in the Presence of IFN-γ. 61
32339990 2020
25
The Curious Case of an Elusive Solitary Plaque. 61
32478007 2020
26
Evidence for Mycobacterium leprae Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India. 61
31933458 2020
27
Tuberculoid Leprosy with External Jugular Vein Thrombosis: A Case Report and Literature Review. 61
32133305 2020
28
Relationship Between sCD163 and mCD163 and Their Implication in the Detection and Typing of Leprosy. 61
32581565 2020
29
Tuberculoid leprosy: An in vivo microvascular evaluation of cutaneous lesions. 61
31929590 2020
30
Secondary syphilis mimicking tuberculoid leprosy in an HIV-positive individual: a case report. 61
31558132 2019
31
Dermatoscopy in leprosy and its correlation with clinical spectrum and histopathology: a prospective observational study. 61
31004456 2019
32
Pathogenesis of Leprosy: An Insight Into B Lymphocytes and Plasma Cells. 61
30422829 2019
33
Leprosy in the post-elimination era: a clinico-epidemiological study from a northern Indian tertiary care hospital. 61
30901062 2019
34
Major risk factors for leprosy in a non-endemic area of the United States: A case series. 61
31193361 2019
35
Transcription factors STAT-4, STAT-6 and CREB regulate Th1/Th2 response in leprosy patients: effect of M. leprae antigens. 61
30642265 2019
36
Neuritic Leprosy; An Intriguing Re-visit to a Forbidden Ailment. 61
31734684 2019
37
[Atypical Localization of a Case of Leprosy in Lomé (Togo)]. 61
31825189 2019
38
Granuloma multiforme: an uncommon differential for leprosy. 61
30286700 2019
39
Second-harmonic generation imaging analysis can help distinguish sarcoidosis from tuberculoid leprosy. 61
30516038 2018
40
Immunohistochemical characterization of the M4 macrophage population in leprosy skin lesions. 61
30442123 2018
41
Borderline tuberculoid leprosy mimicking sarcoidosis: A case report. 61
30095620 2018
42
Guillain-Barre Syndrome: A Rare Presentation of Borderline Tuberculoid Leprosy with Type 1 Lepra Reaction. 61
30069105 2018
43
A rare case of type 1 leprosy reactions following tetanus infection in a borderline tuberculoid leprosy patient and a literature review. 61
29908564 2018
44
Histomorphometric approach to differentiate skin lesions of tuberculoid leprosy from sarcoidosis. 61
29068075 2018
45
Fate of T Cells and their Secretory Proteins During the Progression of Leprosy. 61
28847289 2018
46
Dermoscopy of borderline tuberculoid leprosy. 61
28833001 2018
47
Serum Levels of Migration Inhibitory Factor (MIF) and In Situ Expression of MIF and Its Receptor CD74 in Lepromatous Leprosy Patients: A Preliminary Report. 61
29487601 2018
48
Emerging Concepts of Adaptive Immunity in Leprosy. 61
29686668 2018
49
BCG and Adverse Events in the Context of Leprosy. 61
29670618 2018
50
Hansen's Neuritis Revisited - A Clinicopathological Study. 61
29456344 2018

Variations for Tuberculoid Leprosy

Expression for Tuberculoid Leprosy

Search GEO for disease gene expression data for Tuberculoid Leprosy.

Pathways for Tuberculoid Leprosy

Pathways related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 TNF TLR2 TGFB1 LILRA2 IL2RA IL2
2
Show member pathways
13.85 TNF TGFB3 TGFB2 TGFB1 IL2RA IL2
3
Show member pathways
13.73 TNF TGFB3 TGFB2 TGFB1 IL2RA IL2
4
Show member pathways
13.57 TNF TGFB3 TGFB2 TGFB1 IL2RA IL2
5
Show member pathways
13.47 TNF TLR2 TGFB3 TGFB2 TGFB1 IL2RA
6
Show member pathways
13.4 TNF TGFB1 IL2RA IL2 IL10 IFNG
7
Show member pathways
13.36 TNF TGFB3 TGFB2 TGFB1 IL2RA IL2
8
Show member pathways
13.28 TNF TLR2 TGFB3 TGFB2 TGFB1 IL2
9
Show member pathways
13.11 TGFB3 TGFB2 TGFB1 IL2RA IL2 BMP6
10
Show member pathways
13.09 TGFB3 TGFB2 TGFB1 IL2RA IL2 BMP6
11
Show member pathways
12.95 TNF TGFB1 IL2RA IL2 IL10 IFNG
12 12.9 TGFB3 TGFB2 TGFB1 IL2RA IL2 IFNG
13
Show member pathways
12.88 TNF TLR2 IL2RA IL2 IFNG HSPA1A
14
Show member pathways
12.83 TNF TLR2 IL2RA IL2 IFNG
15 12.81 TNF TGFB3 TGFB2 TGFB1 HSPA1A
16
Show member pathways
12.8 TNF TLR2 TGFB3 TGFB2 TGFB1 IL2
17
Show member pathways
12.72 TNF TGFB2 TGFB1 LILRA2 IL10 IFNG
18
Show member pathways
12.71 TNF TLR2 TGFB1 IL2 IL10 IFNG
19
Show member pathways
12.7 TNF IL2RA IL2 IL10 IFNG CD4
20
Show member pathways
12.65 TNF IL2 IL10 IFNG CD4
21 12.64 TNF TLR2 IL2RA IL2 IL10 IFNG
22
Show member pathways
12.56 TNF TLR2 TGFB3 TGFB2 TGFB1 IL2RA
23
Show member pathways
12.45 IL2RA IL2 IL10 IFNG
24 12.45 TNF TGFB3 TGFB2 TGFB1 IL2RA IL2
25
Show member pathways
12.44 TGFB3 TGFB2 TGFB1 IL2 BMP6
26
Show member pathways
12.41 TNF IL2RA IL2 IL10 CCR6
27
Show member pathways
12.36 TNF TGFB3 TGFB2 TGFB1 IL2RA IL2
28
Show member pathways
12.36 TNF TLR2 TGFB3 TGFB2 TGFB1 IL10
29 12.35 TNF TLR2 TGFB2 TGFB1
30 12.31 TNF TLR2 TGFB3 TGFB2 TGFB1 IFNG
31 12.31 TNF TLR2 TGFB3 TGFB2 TGFB1 IL10
32
Show member pathways
12.3 TNF TGFB3 TGFB2 TGFB1
33 12.29 TGFB3 TGFB2 TGFB1 BMP6
34 12.22 TGFB3 TGFB2 TGFB1 BMP6
35 12.15 TNF IL2 IL10 CD4
36
Show member pathways
12.15 TGFB3 TGFB2 TGFB1 IL10
37 12.12 TNF IL2RA IL2 IL10 IFNG CD4
38 12.08 TNF TGFB1 IL2 IFNG
39
Show member pathways
12.05 IL2RA IL2 IFNG CD4
40 12.01 TNF TGFB3 TGFB2 TGFB1 IFNG BMP6
41 11.99 TNF TGFB3 TGFB2 TGFB1
42 11.99 TNF TLR2 TGFB3 TGFB2 TGFB1 IFNG
43 11.98 TNF IL2RA CD4 CD1B
44
Show member pathways
11.97 TLR2 TGFB3 TGFB2 TGFB1 IFNG CD4
45 11.96 TGFB3 TGFB2 TGFB1 BMP6
46 11.92 TGFB3 TGFB2 TGFB1
47 11.88 TGFB3 TGFB2 TGFB1
48 11.88 TNF IL2RA IL2 IL10 IFNG CD4
49 11.86 TNF TGFB1 IL2 IL10 IFNG CD4
50
Show member pathways
11.85 TNF IL2RA IL2 IFNG

GO Terms for Tuberculoid Leprosy

Cellular components related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TNF TGFB3 TGFB2 TGFB1 IL2 IL10
2 external side of plasma membrane GO:0009897 9.65 TNF IL2RA CD4 CD1B CCR6
3 extracellular region GO:0005576 9.65 TNF TGFB3 TGFB2 TGFB1 LILRA2 IL2
4 platelet alpha granule lumen GO:0031093 9.5 TGFB3 TGFB2 TGFB1
5 cell surface GO:0009986 9.23 TNF TLR2 TGFB3 TGFB1 IL2RA CD4

Biological processes related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.23 TNF TLR2 TGFB3 TGFB1 IL2 IL10
2 immune system process GO:0002376 10.2 TLR2 LILRA2 IL2RA IL2 CD4 CD1B
3 positive regulation of cell proliferation GO:0008284 10.1 TGFB3 TGFB2 TGFB1 IL2 IFNG BMP6
4 inflammatory response GO:0006954 10.09 TNF TLR2 TGFB1 IL2RA BMP6
5 positive regulation of gene expression GO:0010628 10.06 TNF TLR2 TGFB1 IFNG HSPA1A BMP6
6 MAPK cascade GO:0000165 10.05 TNF TGFB1 IL2RA IL2
7 negative regulation of cell proliferation GO:0008285 10.03 TLR2 TGFB3 TGFB2 TGFB1 IL10 HSPA1A
8 regulation of cell proliferation GO:0042127 10.02 TNF TGFB3 TGFB2 TGFB1
9 response to hypoxia GO:0001666 10 TLR2 TGFB3 TGFB2 TGFB1
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.98 TNF TLR2 TGFB1 HSPA1A
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.93 TGFB1 CD4 BMP6
12 positive regulation of protein phosphorylation GO:0001934 9.93 TNF TGFB1 IL2 IFNG CD4
13 positive regulation of tumor necrosis factor production GO:0032760 9.92 TLR2 LILRA2 IFNG
14 response to organic substance GO:0010033 9.92 TNF TGFB1 IL10
15 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.91 TGFB3 TGFB1 HSPA1A
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL2 IFNG
17 cytokine-mediated signaling pathway GO:0019221 9.91 TNF TGFB1 IL2RA IL2 IL10 CD4
18 response to glucocorticoid GO:0051384 9.9 TNF IL10 BMP6
19 positive regulation of interleukin-8 production GO:0032757 9.9 TNF TLR2 HSPA1A
20 humoral immune response GO:0006959 9.89 TNF IFNG CCR6
21 positive regulation of interleukin-1 beta production GO:0032731 9.88 TNF LILRA2 IFNG
22 inner ear development GO:0048839 9.88 TGFB3 TGFB2 TGFB1
23 positive regulation of protein complex assembly GO:0031334 9.88 TNF TGFB1 IFNG
24 positive regulation of cytokine production GO:0001819 9.88 TNF IL10 IFNG
25 positive regulation of inflammatory response GO:0050729 9.88 TNF TLR2 IL2 IFNG
26 positive regulation of interleukin-6 production GO:0032755 9.87 TNF TLR2 LILRA2 IFNG
27 positive regulation of cell division GO:0051781 9.86 TGFB3 TGFB2 TGFB1
28 positive regulation of epithelial to mesenchymal transition GO:0010718 9.86 TGFB3 TGFB2 TGFB1
29 negative regulation of T cell proliferation GO:0042130 9.85 TGFB1 IL2RA IL10
30 T cell differentiation GO:0030217 9.85 TGFB1 IL2 CD4
31 positive regulation of chemokine production GO:0032722 9.85 TNF TLR2 IFNG
32 positive regulation of bone mineralization GO:0030501 9.85 TGFB3 TGFB1 BMP6
33 BMP signaling pathway GO:0030509 9.85 TGFB3 TGFB2 TGFB1 BMP6
34 negative regulation of mitotic cell cycle GO:0045930 9.84 TNF TGFB1 IL10
35 positive regulation of epithelial cell migration GO:0010634 9.82 TGFB2 IFNG CCR6
36 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF TLR2 TGFB1
37 microglial cell activation GO:0001774 9.81 TNF TLR2 IFNG
38 positive regulation of T cell proliferation GO:0042102 9.81 IL2RA IL2 CORO1A CD4
39 T cell homeostasis GO:0043029 9.8 TGFB1 IL2RA CORO1A
40 SMAD protein signal transduction GO:0060395 9.8 TGFB3 TGFB2 TGFB1 BMP6
41 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.78 TGFB3 TGFB2 TGFB1 BMP6
42 cell-cell junction organization GO:0045216 9.77 TGFB3 TGFB2 TGFB1
43 positive regulation of protein secretion GO:0050714 9.76 TGFB3 TGFB2 TGFB1 BMP6
44 positive regulation of signaling receptor activity GO:2000273 9.75 IL10 IFNG
45 pathway-restricted SMAD protein phosphorylation GO:0060389 9.75 TGFB2 TGFB1
46 positive regulation of regulatory T cell differentiation GO:0045591 9.75 TGFB1 IL2
47 cell activation GO:0001775 9.75 TLR2 TGFB1
48 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.74 TNF TGFB1
49 negative regulation of amyloid-beta clearance GO:1900222 9.74 TNF IFNG
50 positive regulation of MHC class II biosynthetic process GO:0045348 9.74 IL10 IFNG

Molecular functions related to Tuberculoid Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.67 TLR2 LILRA2 CD4 CCR6
2 transforming growth factor beta receptor binding GO:0005160 9.5 TGFB3 TGFB2 TGFB1
3 lipopeptide binding GO:0071723 9.43 TLR2 CD1B
4 type II transforming growth factor beta receptor binding GO:0005114 9.43 TGFB3 TGFB2 TGFB1
5 growth factor activity GO:0008083 9.43 TGFB3 TGFB2 TGFB1 IL2 IL10 BMP6
6 type I transforming growth factor beta receptor binding GO:0034713 9.4 TGFB3 TGFB1
7 type III transforming growth factor beta receptor binding GO:0034714 9.33 TGFB3 TGFB2 TGFB1
8 cytokine activity GO:0005125 9.23 TNF TGFB3 TGFB2 TGFB1 IL2 IL10

Sources for Tuberculoid Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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