Tuberculous Epididymitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TBR003 MIFTS: 31	Tuberculous Epididymitis Categories: Infectious diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Tuberculous Epididymitis

MalaCards integrated aliases for Tuberculous Epididymitis:

Name: Tuberculous Epididymitis ¹² ¹⁵

Tuberculosis of Epididymis ⁷¹

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1251

ICD9CM ³⁴ 016.4

SNOMED-CT ⁶⁷ 83652003

UMLS ⁷¹ C0152814

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Summaries for Tuberculous Epididymitis

Disease Ontology : ¹² An urogenital tuberculosis that is located in epididymis, has symptom pain and has symptom scrotal swelling.

MalaCards based summary : Tuberculous Epididymitis, also known as tuberculosis of epididymis, is related to epididymo-orchitis and pyuria, and has symptoms including pain and scrotal swelling. An important gene associated with Tuberculous Epididymitis is CGB3 (Chorionic Gonadotropin Subunit Beta 3), and among its related pathways/superpathways are Overview of nanoparticle effects and Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include epididymis, prostate and testis, and related phenotype is homeostasis/metabolism.

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Related Diseases for Tuberculous Epididymitis

Diseases related to Tuberculous Epididymitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)

#	Related Disease	Score	Top Affiliating Genes
1	epididymo-orchitis	30.6	KLK3 CRP AFP
2	pyuria	30.5	KLK3 CRP
3	pulmonary tuberculosis	29.7	VDR TNF CRP
4	nephrolithiasis, calcium oxalate	29.5	VDR CYP27B1 CRP AVP
5	extrapulmonary tuberculosis	29.4	VDR TNF CRP
6	acquired immunodeficiency syndrome	29.3	TNF POMC CRP
7	mixed germ cell tumor	10.5	CGB3 AFP
8	testicular seminoma	10.5	CGB3 AFP
9	chromosomal triplication	10.5	CGB3 AFP
10	liver inflammatory pseudotumor	10.5	CRP AFP
11	testicular infarct	10.5	CRP AFP
12	cardiac tuberculosis	10.4	EHD1 CRP
13	mediastinum teratoma	10.4	POMC CRP
14	glossopharyngeal nerve paralysis	10.4	KLK3 AFP
15	lung oat cell carcinoma	10.4	POMC AVP
16	pituitary infarct	10.4	POMC AVP
17	nodular nonsuppurative panniculitis	10.4	POMC CRP
18	paralytic ileus	10.4	CRP AVP
19	hypothalamic disease	10.4	POMC AVP
20	wissler's syndrome	10.4	POMC CRP
21	prostate adenoid cystic carcinoma	10.4	POMC KLK3
22	sheehan syndrome	10.4	POMC AVP
23	arachnoiditis	10.4	POMC CRP
24	olfactory nerve neoplasm	10.4	POMC AVP
25	choriocarcinoma of ovary	10.3	EHD1 AFP
26	cranial nerve malignant neoplasm	10.3	POMC AVP
27	atypical depressive disorder	10.3	POMC CRP
28	malignant leydig cell tumor	10.3	CALB2 AFP
29	malignant sertoli cell tumor	10.3	CALB2 AFP
30	cranial nerve neoplasm	10.3	POMC AVP
31	rete testis neoplasm	10.3	CALB2 AFP
32	rete testis adenocarcinoma	10.3	CALB2 AFP
33	adult type testicular granulosa cell tumor	10.3	CALB2 AFP
34	testicular granulosa cell tumor	10.3	CALB2 AFP
35	dermoid cyst of ovary	10.3	CALB2 AFP
36	hematocele of tunica vaginalis testis	10.3	CALB2 AFP
37	aids phobia	10.3	PLEKHG5 EHD1
38	scrotum neoplasm	10.3	CALB2 AFP
39	epididymal neoplasm	10.3	CALB2 AFP
40	ovarian wilms' cancer	10.3	CALB2 AFP
41	subacute leukemia	10.3	POMC PLEKHG5
42	ovarian germ cell teratoma	10.3	CALB2 AFP
43	benign mesothelioma	10.3	CALB2 AFP
44	lumbosacral lipoma	10.3	PLEKHG5 EHD1
45	cystadenofibroma	10.3	CALB2 AFP
46	pericardial tuberculosis	10.3	CRP CALB2
47	endodermal sinus tumor	10.3	KLK3 CGB3 AFP
48	juvenile type testicular granulosa cell tumor	10.2	CALB2 AFP
49	classic congenital mesoblastic nephroma	10.2	CD2AP AFP
50	diabetes insipidus	10.2	POMC AVP AFP

Graphical network of the top 20 diseases related to Tuberculous Epididymitis:

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Symptoms & Phenotypes for Tuberculous Epididymitis

Symptoms:

¹²

• pain

• scrotal swelling

MGI Mouse Phenotypes related to Tuberculous Epididymitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.36	AFP AVP CAPNS1 CD2AP CRP CYP27B1

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Drugs & Therapeutics for Tuberculous Epididymitis

Search Clinical Trials , NIH Clinical Center for Tuberculous Epididymitis

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Genetic Tests for Tuberculous Epididymitis

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Anatomical Context for Tuberculous Epididymitis

The Foundational Model of Anatomy Ontology organs/tissues related to Tuberculous Epididymitis:

¹⁹

Epididymis

MalaCards organs/tissues related to Tuberculous Epididymitis:

⁴⁰

Prostate, Testis, Heart, Lung, Skin, Bone, Kidney

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Publications for Tuberculous Epididymitis

Articles related to Tuberculous Epididymitis:

(show top 50) (show all 108)

#	Title	Authors	PMID	Year
1	Nodular granulomatous phlebitis of the penis in a patient with antecedent tuberculous epididymitis: The first reported case. ⁶¹	Kiyohara T...Tanimura H	31245863	2019
2	Histopathological Spectrum of Tumor and  Tumor-like Lesions of the Paratestis in a  Tertiary Care Hospital. ⁶¹	Khandeparkar SG...Pinto RG	26674546	2015
3	Tuberculous Epididymitis. ⁶¹	Herman KO...Lee ER	25945724	2015
4	Tuberculous Epididymitis: A Case of Tuberculous Epididymitis That Was the Presenting Manifestation of Extrapulmonary and Pulmonary Tuberculoses. ⁶¹	Woldenberg N...Hansen G	25851823	2015
5	[Tuberculous epididymitis after Bacillus Calmette-Guérin intravesical therapy : a case report]. ⁶¹	Uno T...Egawa S	25001646	2014
6	Sonographic findings of tuberculous vasitis. ⁶¹	Yang DM...Lim SJ	24764347	2014
7	Unusual isolated tubercolous epididymitis. Case report. ⁶¹	Dell'Atti L	24979105	2014
8	[IFN-gamma enzyme-linked immunospot assay versus PPD tuberculin skin test in the diagnosis of tuberculous epididymitis]. ⁶¹	Huang H...Yang DF	22774610	2012
9	Tuberculous epididymitis. ⁶¹	Singh D...Voci S	22634794	2012
10	Isolated tuberculous epididymitis presenting as a painless scrotal tumor. ⁶¹	Kho VK...Chan PH	22721625	2012
11	[A case of tuberculous epididymitis after Bacillus Calmette-Guérin intravesical instillation therapy for bladder cancer]. ⁶¹	Uesaka Y...Ichimaru N	22450841	2012
12	Tuberculous epididymitis-cytology-based diagnosis. ⁶¹	Upasham P...Kawane S	22670514	2012
13	[Unusual locations of tuberculosis: three case reports]. ⁶¹	Ralandison S...Rapelanoro Rabenja F	19233520	2009
14	Tuberculous epididymitis presenting as huge scrotal tumor. ⁶¹	Yu-Hung Lai A...Huang CY	18619652	2009
15	Tuberculous epididymitis following intravesical Bacillus Calmette-Guérin immunotherapy. ⁶¹	Hoag N...Eddy RJ	19364433	2009
16	Isolated tuberculous epididymitis masquerading as a scrotal tumor. ⁶¹	Miu WC...Luo FJ	19255699	2008
17	[Diagnosis and treatment of isolated tuberculous epididymitis]. ⁶¹	Chen ZB...Song YS	19157104	2008
18	[Case of tuberculous epididymitis caused by intravesical BCG therapy]. ⁶¹	Koizumi T...Kanayama HO	18975579	2008
19	Tuberculous epididymo-orchitis and prostatitis: a case report. ⁶¹	Ludwig M...Weidner W	18336455	2008
20	[The first "fillers", vaseline and paraffin. From miracle to disaster]. ⁶¹	Glicenstein J	16860452	2007
21	Fine needle aspiration of epididymal nodules in Chandigarh, north India: an audit of 228 cases. ⁶¹	Gupta N...Nijhawan R	16879267	2006
22	Tuberculous epididymitis presenting with Addison's disease: a rare case. ⁶¹	Guler ZM...Erdogan Y	16895290	2006
23	[Diagnosis and differential diagnosis value of ultrasound in epididymal mass]. ⁶¹	Li SQ...Na YQ	16519159	2006
24	[Bilateral tuberculous epididymitis after intravesical Bacillus Calmette-Guerin therapy]. ⁶¹	Shigehara K...Takemae K	16440736	2005
25	Tuberculosis, bronchiectasis, and infertility: what ailed George Orwell? ⁶¹	Ross JJ	16267732	2005
26	Tuberculous epididymitis: a case report and literature review. ⁶¹	Liu HY...Sun GH	16110362	2005
27	Tuberculous epididymitis and fertility in North Jordan. ⁶¹	Al-Ghazo MA...Amarin ZO	16127515	2005
28	Isolated tuberculous epididymitis: a review of forty cases. ⁶¹	Viswaroop BS...Gopalakrishnan G	16006701	2005
29	Painless scrotal swelling: ultrasonographical features with pathological correlation. ⁶¹	Muttarak M...Chaiwun B	15800728	2005
30	Fine-needle aspiration cytology versus open biopsy for evaluation of chronic epididymal lesions: a prospective study. ⁶¹	Viswaroop B...Gopalakrishnan G	16118093	2005
31	Tuberculous epididymitis with extensive retroperitoneal and mediastinal involvement. ⁶¹	Oben FT...Ahaghotu CA	15245961	2004
32	Tuberculous epididymitis associated with abdominal lymphadenopathy (2004:1b). ⁶¹	De Backer AI...Bomans P	15085800	2004
33	[Tuberculous epididymitis caused by intravesical BCG therapy: a case report]. ⁶¹	Ishizu K...Kobayashi T	14598693	2003
34	[Tuberculous epididymitis caused by Mycobacterium bovis]. ⁶¹	Mateos Colino A...Fernandez MA	12731446	2003
35	Differential diagnosis of focal epididymal lesions with gray scale sonographic, color Doppler sonographic, and clinical features. ⁶¹	Yang DM...Cho H	12562118	2003
36	[Epididymal tuberculosis: report of a case with particular color Doppler ultrasonography finding]. ⁶¹	Benchekroun A...Faik M	12611141	2002
37	[Tuberculous epididymitis following intravesical Bacillus Calmette-Guérin therapy]. ⁶¹	Okadome A...Hiratsuka Y	12056045	2002
38	[Orchiectomy for tuberculous epididymitis: a report of two cases with intractable to antituberculosis treatment]. ⁶¹	Kunichika N...Takeyama H	11712389	2001
39	Tuberculous epididymitis and epididymo-orchitis: sonographic appearances. ⁶¹	Muttarak M...Chaiwun B	11373214	2001
40	[A case of tuberculosis of the prostate presenting as endoscopically cavitary change]. ⁶¹	Oka N...Kagawa S	11449704	2001
41	[Lymphotropic therapy with antitubercular agents in the treatment of tuberculous epididymitis]. ⁶¹	Gamazkov RV...Ivanova LA	11523363	2001
42	Chronic tuberculous epididymitis: color Doppler US findings with histopathologic correlation. ⁶¹	Yang DM...Chung JW	10931999	2000
43	[A case of tuberculous epididymitis which was difficult to distinguish from a testicular tumor]. ⁶¹	Kimata R...Akimoto M	11019378	2000
44	Serious complications of tuberculous epididymitis. ⁶¹	Skoutelis A...Bassaris H	10879650	2000
45	The outcome of sperm retrieval and intracytoplasmic sperm injection in patients with obstructive azoospermia: impact of previous tuberculous epididymitis. ⁶¹	Moon SY...Lee JY	10478323	1999
46	[Epididymal manifestations of urogenital tuberculosis]. ⁶¹	Gueye SM...Mensah A	9615934	1998
47	Sonographic findings in tuberculous epididymitis and epididymo-orchitis. ⁶¹	Chung JJ...Lee JT	9282805	1997
48	Treatment of tuberculous epididymitis by intratunical rifampicin injection. ⁶¹	Shafik A	8743356	1996
49	[Epididymal manifestations of urogenital tuberculosis]. ⁶¹	Gueye SM...Mensah A	9827094	1996
50	Tuberculous epididymitis presenting as acute hydrocele. ⁶¹	Guy RJ	7562703	1995

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Genes for Tuberculous Epididymitis

Genes related to Tuberculous Epididymitis (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CGB3	Chorionic Gonadotropin Subunit Beta 3	Protein Coding	6.86	GeneCards inferred via : Publications (show sections)
2	ZNF77	Zinc Finger Protein 77	Protein Coding	6.1	DISEASES inferred ¹⁵
3	AVP	Arginine Vasopressin	Protein Coding	4.8	DISEASES inferred ¹⁵
4	AFP	Alpha Fetoprotein	Protein Coding	4.73	DISEASES inferred ¹⁵
5	CAPNS1	Calpain Small Subunit 1	Protein Coding	4.6	DISEASES inferred ¹⁵
6	CRP	C-Reactive Protein	Protein Coding	4.19	DISEASES inferred ¹⁵
7	EHD1	EH Domain Containing 1	Protein Coding	4.16	DISEASES inferred ¹⁵
8	POMC	Proopiomelanocortin	Protein Coding	4.13	DISEASES inferred ¹⁵
9	KLK3	Kallikrein Related Peptidase 3	Protein Coding	4.06	DISEASES inferred ¹⁵
10	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	4.05	DISEASES inferred ¹⁵
11	PLEKHG5	Pleckstrin Homology And RhoGEF Domain Containing G5	Protein Coding	3.98	DISEASES inferred ¹⁵
12	CALB2	Calbindin 2	Protein Coding	3.85	DISEASES inferred ¹⁵
13	CD2AP	CD2 Associated Protein	Protein Coding	3.74	DISEASES inferred ¹⁵
14	TNF	Tumor Necrosis Factor	Protein Coding	3.5	DISEASES inferred ¹⁵
15	VDR	Vitamin D Receptor	Protein Coding	3.4	DISEASES inferred ¹⁵

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Variations for Tuberculous Epididymitis

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Expression for Tuberculous Epididymitis

Search GEO for disease gene expression data for Tuberculous Epididymitis.

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Pathways for Tuberculous Epididymitis

Pathways related to Tuberculous Epididymitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Overview of nanoparticle effects ¹	10.54	TNF CRP
2	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.45	VDR TNF CYP27B1
3	RXR and RAR heterodimerization with other nuclear receptor ¹	10.3	VDR TNF
4	Vitamin D Metabolism ¹	9.96	VDR CYP27B1

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GO Terms for Tuberculous Epididymitis

Cellular components related to Tuberculous Epididymitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.7	TNF POMC KLK3 CRP CGB3 AVP
2	secretory granule	GO:0030141	9.13	POMC KLK3 AVP
3	endocytic vesicle	GO:0030139	8.8	PLEKHG5 EHD1 CD2AP

Biological processes related to Tuberculous Epididymitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of keratinocyte differentiation	GO:0045618	9.26	VDR CYP27B1
2	vitamin D metabolic process	GO:0042359	9.16	VDR CYP27B1
3	negative regulation of lipid storage	GO:0010888	8.96	TNF CRP
4	positive regulation of vitamin D 24-hydroxylase activity	GO:0010980	8.62	VDR CYP27B1

Molecular functions related to Tuberculous Epididymitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	8.8	POMC CGB3 AVP

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Sources for Tuberculous Epididymitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia