MCID: TBR011
MIFTS: 53

Tuberculous Meningitis

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Tuberculous Meningitis

MalaCards integrated aliases for Tuberculous Meningitis:

Name: Tuberculous Meningitis 53 59
Tubercular Meningitis 53 59
Tuberculosis, Meningeal 73
Meningitis Tuberculous 55
Tb Meningitis 53
Tbm 59

Classifications:



External Ids:

Orphanet 59 ORPHA499004
ICD10 33 A17.0
UMLS 73 C0041318

Summaries for Tuberculous Meningitis

MalaCards based summary : Tuberculous Meningitis, also known as tubercular meningitis, is related to extrapulmonary tuberculosis and bacterial meningitis. An important gene associated with Tuberculous Meningitis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related phenotypes are immune system and cardiovascular system

Wikipedia : 76 Tuberculous meningitis is also known as TB meningitis or tubercular meningitis. Tuberculous meningitis... more...

Related Diseases for Tuberculous Meningitis

Diseases related to Tuberculous Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 extrapulmonary tuberculosis 33.0 ADA CCL2 TLR2
2 bacterial meningitis 30.7 CXCL8 MMP9 TLR2 TNF
3 meningitis 30.7 ADA CCL2 CXCL8 LYZ MMP9 TLR2
4 endocarditis 30.4 CXCL8 TLR2 TNF
5 visceral leishmaniasis 30.2 ADA CXCL8 TLR2 TNF
6 neurosyphilis 29.5 CXCL8 TLR2
7 pulmonary tuberculosis 29.3 ADA CCL3 NAT2 TLR2 TNF
8 tracheobronchomalacia 11.8
9 tuberculous peritonitis 11.1
10 bronchomalacia 10.9
11 mycobacterium chelonae 10.9 CXCL8 TLR2
12 autoimmune inner ear disease 10.8 MMP9 TNF
13 haemophilus influenzae 10.7 CXCL8 TLR2 TNF
14 mycobacterium abscessus 10.7 CXCL8 TLR2 TNF
15 mycobacterium kansasii 10.7 CXCL8 TLR2
16 middle ear disease 10.7 CXCL8 TLR2 TNF
17 tungiasis 10.7 CXCL8 TNF
18 clonorchiasis 10.7 CXCL8 TGFB1 TNF
19 bacterial vaginosis 10.7 CXCL8 TLR2 TNF
20 herpes simplex virus keratitis 10.7 CCL2 CXCL8
21 transverse myelitis 10.7 CXCL8 MMP9 TNF
22 primary bacterial infectious disease 10.7 ADA TLR2 TNF
23 prostatitis 10.7 CXCL8 TGFB1 TNF
24 diabetic foot ulcers 10.7 MMP9 TGFB1
25 vibratory urticaria 10.6 CXCL8 MMP9
26 viral meningitis 10.6 ADA CCL2 CXCL8
27 allergic contact dermatitis 10.6 CXCL8 NAT2 TNF
28 viral encephalitis 10.6 CCL2 CXCL8 TNF
29 chlamydia 10.6 CXCL8 TLR2 TNF
30 toxic shock syndrome 10.6 CXCL8 TLR2 TNF
31 bronchiolitis obliterans 10.6 CXCL8 MMP9 TNF
32 pyelonephritis 10.6 CCL2 CXCL8 TNF
33 severe acute respiratory syndrome 10.6 CCL2 CXCL8 TNF
34 gingivitis 10.6 CXCL8 MMP9 TNF
35 leukoregulin 10.6 CXCL8 TGFB1
36 scleritis 10.6 CCL2 MMP9 TNF
37 otitis media 10.6 CXCL8 TLR2 TNF
38 chronic fatigue syndrome 10.6 CXCL8 TGFB1 TNF
39 trench fever 10.6 TLR2 TNF
40 alcoholic hepatitis 10.6 CCL2 CXCL8 TNF
41 spinal cord injury 10.6 MMP9 TGFB1 TNF
42 bone inflammation disease 10.6 CCL2 CXCL8 TNF
43 female reproductive system disease 10.5 CXCL8 TNF VEGFA
44 angiokeratoma circumscriptum 10.5 MMP9 VEGFA
45 pelvic inflammatory disease 10.5 CCL2 MMP9 TLR2
46 beryllium disease 10.5 TGFB1 TNF
47 congenital granular cell tumor 10.5 ENO2 LYZ
48 critical limb ischemia 10.5 TNF VEGFA
49 macular holes 10.5 CCL2 CXCL8 VEGFA
50 large cell carcinoma with rhabdoid phenotype 10.5 ENO2 VEGFA

Graphical network of the top 20 diseases related to Tuberculous Meningitis:



Diseases related to Tuberculous Meningitis

Symptoms & Phenotypes for Tuberculous Meningitis

MGI Mouse Phenotypes related to Tuberculous Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.14 ADA ALOX5 CCL2 GGT1 LTA4H LYZ
2 cardiovascular system MP:0005385 10.13 ADA ALOX5 LYZ MMP9 NPPA TGFB1
3 hematopoietic system MP:0005397 10.13 LYZ MMP9 NPPA TGFB1 TLR2 TNF
4 digestive/alimentary MP:0005381 10 ADA LYZ MMP9 TGFB1 TLR2 TNF
5 muscle MP:0005369 9.91 ADA MMP9 NPPA TGFB1 TLR2 TNF
6 renal/urinary system MP:0005367 9.86 ADA GGT1 LYZ MMP9 NPPA TGFB1
7 neoplasm MP:0002006 9.8 LYZ MMP9 TGFB1 TLR2 TNF VEGFA
8 reproductive system MP:0005389 9.76 ADA GGT1 LYZ MMP9 NAT2 TGFB1
9 respiratory system MP:0005388 9.56 MMP9 TGFB1 TLR2 TNF VEGFA ADA
10 skeleton MP:0005390 9.28 ADA ALOX5 GGT1 LYZ MMP9 TGFB1

Drugs & Therapeutics for Tuberculous Meningitis

Drugs for Tuberculous Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
2 Dexamethasone acetate Phase 4,Phase 2,Phase 3 1177-87-3
3 glucocorticoids Phase 4,Phase 2,Phase 3
4
protease inhibitors Phase 4,Phase 2,Phase 3
5 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
6 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
7 Hormone Antagonists Phase 4,Phase 2,Phase 3
8 Hormones Phase 4,Phase 2,Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
10 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
11 Antiemetics Phase 4,Phase 2,Phase 3
12 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
13 BB 1101 Phase 4,Phase 2,Phase 3
14 Autonomic Agents Phase 4,Phase 2,Phase 3
15 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
16
Rifampicin Approved Phase 2, Phase 3,Phase 1 13292-46-1 5458213 5381226
17
Ethambutol Approved Phase 2, Phase 3,Phase 1 74-55-5 3279 14052
18
Pyrazinamide Approved, Investigational Phase 2, Phase 3,Phase 1 98-96-4 1046
19
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 65-23-6 1054
20
Pyridoxal Approved, Nutraceutical Phase 2, Phase 3 66-72-8 1050
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
22 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3,Phase 1,Not Applicable
23 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 1,Not Applicable
24 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Not Applicable
25 Micronutrients Phase 2, Phase 3
26 Trace Elements Phase 2, Phase 3
27 Vitamin B 6 Phase 2, Phase 3
28 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
29 Vitamin B Complex Phase 2, Phase 3
30 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
31 Vitamins Phase 2, Phase 3
32 Antitubercular Agents Phase 2, Phase 3,Phase 3,Phase 1
33 Liver Extracts Phase 3
34 Folate Nutraceutical Phase 2, Phase 3
35 Vitamin B9 Nutraceutical Phase 2, Phase 3
36
Moxifloxacin Approved, Investigational Phase 2 354812-41-2, 151096-09-2 152946
37
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
38 Estradiol valerate Approved, Investigational, Vet_approved Phase 2 979-32-8
39
Norgestimate Approved, Investigational Phase 2 35189-28-7 6540478
40
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
41
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
42
Polyestradiol phosphate Approved Phase 2 28014-46-2
43
Isoniazid Approved, Investigational Phase 1, Phase 2 54-85-3 3767
44
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
45
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
46
BCG vaccine Investigational Phase 2
47 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2,Not Applicable
48 Analgesics Phase 2
49 Fibrinolytic Agents Phase 2
50 Adjuvants, Immunologic Phase 2

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Not yet recruiting NCT02588196 Phase 4 Dexamethasone acetate
2 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
3 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
4 Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Recruiting NCT03092817 Phase 3 Dexamethasone
5 Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Recruiting NCT03100786 Phase 3 Dexamethasone
6 A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis Completed NCT02237365 Phase 2 81mg aspirin;1000mg aspirin;Placebo
7 Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Completed NCT01802502 Phase 2 Rifampicin intravenous;Oral rifampicin
8 Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study Completed NCT01158755 Phase 2 Moxifloxacin
9 Safety and Immunogenicity of MVA85A Prime and Bacille Calmette-Guerin Boost Vaccination Completed NCT01650389 Phase 2
10 Optimizing Treatment to Improve TBM Outcomes in Children Recruiting NCT02958709 Phase 1, Phase 2 High-dose: RIF, INH, PZA, EMB;High dose: RIF, INH, PZA, LEVO;Standard of care: RIF, INH, PZA, EMB
11 Pharmacokinetic Study of Linezolid for TB Meningitis Not yet recruiting NCT03537495 Phase 2 Linezolid
12 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
13 Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Unknown status NCT00433719 Not Applicable Combivir and efavirenz
14 Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF Completed NCT01371916
15 Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone Completed NCT01317654
16 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
17 Diagnostics and Pharmacotherapy for Severe Forms of TB (DMID 15-0100) Enrolling by invitation NCT03559582

Search NIH Clinical Center for Tuberculous Meningitis

Genetic Tests for Tuberculous Meningitis

Anatomical Context for Tuberculous Meningitis

MalaCards organs/tissues related to Tuberculous Meningitis:

41
Testes, Brain, T Cells, Spinal Cord, Liver, Endothelial, B Cells

Publications for Tuberculous Meningitis

Articles related to Tuberculous Meningitis:

(show top 50) (show all 729)
# Title Authors Year
1
Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. ( 29395996 )
2018
2
Paradoxical Reaction in a Patient with Co-Occurring Tuberculous Meningitis and Pott's Disease. ( 29907737 )
2018
3
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
4
Diagnosis of tuberculous meningitis with invasive pulmonary sampling. ( 29303733 )
2018
5
Development of a clinical prediction rule for tuberculous meningitis in adults in Lima, Peru. ( 29446860 )
2018
6
Use of Linezolid in a Child With Tuberculous Meningitis. ( 29652742 )
2018
7
Absence of cerebrospinal fluid pleocytosis in tuberculous meningitis is a common occurrence in HIV co-infection and a predictor of poor outcomes. ( 29391245 )
2018
8
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
9
A study of atrial and brain natriuretic peptides in tuberculous meningitis and acute encephalitis. ( 29562995 )
2018
10
Microbiological diagnosis of adult tuberculous meningitis in a ten-year cohort in Indonesia. ( 29444749 )
2018
11
Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome. ( 29297432 )
2018
12
Xpert MTB/RIF<sup>Ar</sup> assay for the diagnosis of HIV-related tuberculous meningitis in SALo Paulo, Brazil. ( 29862958 )
2018
13
Diagnostic accuracy of nucleic acid amplification based assays for tuberculous meningitis: A meta-analysis. ( 29758242 )
2018
14
Diagnostic test accuracy of adenosine deaminase for tuberculous meningitis: A systematic review and meta-analysis - An update. ( 29807089 )
2018
15
Diffuse Leptomeningeal Glioneural Tumour Simulating Tuberculous Meningitis in a 13-Year-Old Girl. ( 29301133 )
2018
16
Comparative whole-genome sequence analysis of Mycobacterium tuberculosis isolated from tuberculous meningitis and pulmonary tuberculosis patients. ( 29559684 )
2018
17
Mycobacterium marinum Infection in Zebrafish and Microglia Imitates the Early Stage of Tuberculous Meningitis. ( 29352446 )
2018
18
CSF protein concentration associated with ventriculoperitoneal shunt obstruction in tuberculous meningitis. ( 29914605 )
2018
19
Diagnostic scoring system for tuberculous meningitis among adult patients with non-suppurative and non-bacterial meningitis. ( 29705393 )
2018
20
Predicting mortality of tuberculous meningitis. ( 29860408 )
2018
21
Tuberculous Meningitis during Chemotherapy for Advanced Gastric Cancer. ( 29805373 )
2018
22
Late-onset paradoxical reactions 10A years after treatment for tuberculous meningitis in an HIV-negative patient: a case report. ( 29980175 )
2018
23
Progress on Diagnosis of Tuberculous Meningitis. ( 29536453 )
2018
24
Tuberculous meningitis is associated with higher cerebrospinal HIV-1 viral loads compared to other HIV-1-associated meningitides. ( 29394269 )
2018
25
Is drug-induced hepatitis related to the severity of tuberculous meningitis? ( 29438557 )
2018
26
Expression of autophagy-related genes in cerebrospinal fluid of patients with tuberculous meningitis. ( 29805485 )
2018
27
Correction: optic disc swelling in a patient with tuberculous meningitis: a diagnostic challenge. ( 29348273 )
2018
28
Could omics unlock the secret of surviving tuberculous meningitis? ( 29398390 )
2018
29
Isoniazid and rifampicin heteroresistant Mycobacterium tuberculosis isolated from tuberculous meningitis patients in India. ( 29332649 )
2018
30
Tuberculous meningitis: a roadmap for advancing basic and translational research. ( 29777209 )
2018
31
Chiari malformation and tuberculous meningitis: aetiology and management. ( 29622715 )
2018
32
Evaluation of the GeneXpert MTB/RIF in patients with presumptive tuberculous meningitis. ( 29912907 )
2018
33
Clinical presentations and outcomes of the children with tuberculous meningitis: An experience at a tertiary care hospital. ( 29371710 )
2018
34
Human immunodeficiency virus in patients with tuberculous meningitis: systematic review and meta-analysis. ( 29660820 )
2018
35
Hypovolemia due to cerebral salt wasting may contribute to stroke in tuberculous meningitis. ( 29635544 )
2018
36
Neuromarker Levels Also Predict Mortality in Adult Tuberculous Meningitis. ( 29617975 )
2018
37
Cerebrospinal Fluid Leukotriene B4 and Soluble Tumor Necrosis Factor Receptor II Levels and Treatment Outcome in Tuberculous Meningitis. ( 28859433 )
2017
38
Cytokines do play a role in pathogenesis of tuberculous meningitis: A prospective study from a tertiary care center in India. ( 28716226 )
2017
39
A study of neuroendocrine dysfunction in patients of tuberculous meningitis. ( 28716240 )
2017
40
Rapid Development of Intracranial Aneurysm Associated with Tuberculous Meningitis. ( 29391085 )
2017
41
The application of IS6110-baced loop-mediated isothermal amplification (LAMP) in the early diagnosis of tuberculous meningitis. ( 28915693 )
2017
42
Predictors of adverse outcome in patients of tuberculous meningitis in a multi-centric study from India. ( 28941852 )
2017
43
Contribution of brain CT in the diagnosis of tuberculous meningitis: a case report from Djibouti. ( 28721934 )
2017
44
A predictive score followed by nucleic acid amplification for adult tuberculous meningitis diagnosis in Southern Brazil. ( 28716254 )
2017
45
Unusual case of tuberculous meningitis with discordant ventricular and lumbar cerebrospinal fluid; lessons in the era of world-wide migration. ( 28805285 )
2017
46
Diagnosis of tuberculous meningitis: Current scenario from a Tertiary Neurocare Centre in India. ( 28709486 )
2017
47
Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia. ( 28419315 )
2017
48
Cerebrospinal fluid matrix metalloproteinase 9 levels, blood-brain barrier permeability, and treatment outcome in tuberculous meningitis. ( 28704492 )
2017
49
Optic disc swelling in a patient with tuberculous meningitis: a diagnostic challenge. ( 28794092 )
2017
50
Tuberculous meningitis and hydrocephalus in Filippino de' Medici. ( 28504108 )
2017

Variations for Tuberculous Meningitis

Expression for Tuberculous Meningitis

Search GEO for disease gene expression data for Tuberculous Meningitis.

Pathways for Tuberculous Meningitis

Pathways related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2
Show member pathways
13.29 ALOX5 CCL2 CCL3 CXCL8 MMP9 TGFB1
3
Show member pathways
12.94 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
4
Show member pathways
12.45 CXCL8 MMP9 TGFB1 TLR2 TNF VEGFA
5
Show member pathways
12.27 ALOX5 CCL2 GGT1 TNF
6
Show member pathways
12.27 CCL2 CXCL8 MMP9 TLR2 TNF
7 12.23 MMP9 TGFB1 TLR2 TNF VEGFA
8
Show member pathways
12.2 ALOX5 TGFB1 TLR2 TNF
9 12.09 MMP9 TGFB1 TLR2 TNF VEGFA
10 12.04 CCL2 MMP9 TNF VEGFA
11 11.87 CCL2 MMP9 TNF
12 11.86 CCL3 CXCL8 TGFB1
13 11.85 CCL2 CXCL8 MMP9 TGFB1 TNF
14 11.83 ENO2 NPPA VEGFA
15 11.83 CXCL8 TGFB1 TLR2 TNF
16 11.77 CCL2 MMP9 TGFB1
17 11.72 CCL2 CXCL8 TGFB1 TNF VEGFA
18 11.68 CXCL8 MMP9 VEGFA
19 11.62 MMP9 TGFB1 VEGFA
20
Show member pathways
11.6 CXCL8 MMP9 TNF VEGFA
21 11.56 ALOX5 CCL2 CXCL8 MMP9 TGFB1 TNF
22 11.53 CXCL8 TLR2 TNF
23 11.49 CXCL8 TGFB1 VEGFA
24 11.46 CCL2 TLR2 TNF
25 11.43 CCL2 CCL3 CXCL8 MMP9 TGFB1 TNF
26 11.42 CCL2 CCL3 CXCL8 TNF
27 11.34 CCL2 CXCL8 TGFB1 TLR2 TNF
28 11.29 CCL2 CXCL8 MMP9
29 11.14 CCL2 MMP9 TLR2
30 11.12 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
31 11.11 ALOX5 GGT1 LTA4H
32 10.89 CCL2 CCL3 TNF
33 10.8 TGFB1 TNF
34 10.48 ALOX5 GGT1 LTA4H

GO Terms for Tuberculous Meningitis

Cellular components related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2 cell surface GO:0009986 9.65 ADA TGFB1 TLR2 TNF VEGFA
3 extracellular space GO:0005615 9.47 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2
4 tertiary granule lumen GO:1904724 9.33 LTA4H LYZ MMP9

Biological processes related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.95 CCL2 CCL3 TGFB1 TNF
2 positive regulation of gene expression GO:0010628 9.93 CCL3 MIR29A TGFB1 TLR2 TNF VEGFA
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 CCL2 CCL3 TGFB1 TNF
4 negative regulation of gene expression GO:0010629 9.92 CCL3 MIR29A TGFB1 TNF VEGFA
5 positive regulation of cell migration GO:0030335 9.91 CCL3 MIR29A MMP9 TGFB1 VEGFA
6 positive regulation of protein phosphorylation GO:0001934 9.87 MMP9 TGFB1 TNF VEGFA
7 regulation of signaling receptor activity GO:0010469 9.87 CCL2 CCL3 CXCL8 NPPA TGFB1 TNF
8 positive regulation of protein kinase B signaling GO:0051897 9.86 CCL3 MIR29A TGFB1 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.84 LYZ TLR2 TNF
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.81 TGFB1 TNF VEGFA
11 cellular response to interleukin-1 GO:0071347 9.8 CCL2 CCL3 CXCL8
12 response to hypoxia GO:0001666 9.8 ADA NPPA TGFB1 TLR2 VEGFA
13 chemokine-mediated signaling pathway GO:0070098 9.78 CCL2 CCL3 CXCL8
14 neutrophil chemotaxis GO:0030593 9.77 CCL2 CCL3 CXCL8
15 positive regulation of MAP kinase activity GO:0043406 9.76 TGFB1 TNF VEGFA
16 inflammatory response GO:0006954 9.76 ALOX5 CCL2 CCL3 CXCL8 LYZ TGFB1
17 cellular response to organic cyclic compound GO:0071407 9.73 CCL2 CCL3 TGFB1 TNF
18 positive regulation of protein complex assembly GO:0031334 9.71 TGFB1 TNF VEGFA
19 positive regulation of calcium ion import GO:0090280 9.67 CCL2 CCL3
20 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 CCL2 TLR2
21 embryonic digestive tract development GO:0048566 9.67 ADA CXCL8 TNF
22 protein kinase B signaling GO:0043491 9.67 CCL2 CCL3 TGFB1 TNF
23 induction of positive chemotaxis GO:0050930 9.66 CXCL8 VEGFA
24 response to molecule of bacterial origin GO:0002237 9.66 CXCL8 TLR2
25 macrophage chemotaxis GO:0048246 9.65 CCL2 CCL3
26 negative regulation of phagocytosis GO:0050765 9.65 TGFB1 TLR2
27 cell activation GO:0001775 9.65 CCL3 TGFB1 TLR2
28 PERK-mediated unfolded protein response GO:0036499 9.64 CCL2 CXCL8
29 leukotriene biosynthetic process GO:0019370 9.63 ALOX5 LTA4H
30 response to cholesterol GO:0070723 9.62 CCL3 TGFB1
31 astrocyte cell migration GO:0043615 9.58 CCL2 CCL3
32 leukotriene metabolic process GO:0006691 9.56 ALOX5 GGT1 LTA4H TLR2
33 positive regulation of mononuclear cell migration GO:0071677 9.55 TGFB1 TNF
34 lipopolysaccharide-mediated signaling pathway GO:0031663 9.35 CCL2 CCL3 TGFB1 TLR2 TNF
35 cytokine-mediated signaling pathway GO:0019221 9.23 ALOX5 CCL2 CCL3 CXCL8 MMP9 TGFB1
36 immune response GO:0006955 10.01 CCL2 CCL3 CXCL8 TLR2 TNF
37 neutrophil degranulation GO:0043312 10 ALOX5 LTA4H LYZ MMP9 TLR2

Molecular functions related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.73 CCL3 LYZ MMP9 TGFB1 TNF VEGFA
2 chemokine activity GO:0008009 9.13 CCL2 CCL3 CXCL8
3 cytokine activity GO:0005125 9.1 CCL2 CCL3 CXCL8 TGFB1 TNF VEGFA
4 protein binding GO:0005515 10.06 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2

Sources for Tuberculous Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....