MCID: TBR011
MIFTS: 55

Tuberculous Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Tuberculous Meningitis

MalaCards integrated aliases for Tuberculous Meningitis:

Name: Tuberculous Meningitis 54 60
Tubercular Meningitis 54 60
Tuberculosis, Meningeal 74
Meningitis Tuberculous 56
Tb Meningitis 54
Tbm 60

Classifications:



External Ids:

ICD10 34 A17.0
Orphanet 60 ORPHA499004
UMLS 74 C0041318

Summaries for Tuberculous Meningitis

MalaCards based summary : Tuberculous Meningitis, also known as tubercular meningitis, is related to extrapulmonary tuberculosis and miliary tuberculosis. An important gene associated with Tuberculous Meningitis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and spinal cord, and related phenotypes are cellular and cardiovascular system

Wikipedia : 77 Tuberculous meningitis is also known as TB meningitis or tubercular meningitis. Tuberculous meningitis... more...

Related Diseases for Tuberculous Meningitis

Diseases related to Tuberculous Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 279)
# Related Disease Score Top Affiliating Genes
1 extrapulmonary tuberculosis 32.8 ADA CCL2 TLR2
2 miliary tuberculosis 31.2 ADA ENO2 TNF
3 meningitis 31.0 ADA CCL2 CCL3 CXCL8 LYZ MMP9
4 bacterial meningitis 30.6 CXCL8 MMP9 TLR2 TNF
5 transverse myelitis 30.5 CXCL8 MMP9 TNF
6 mycobacterium marinum 30.4 CXCL8 TLR2
7 pulmonary tuberculosis 30.2 ADA CCL3 NAT2 TLR2 TNF
8 cystitis 30.1 CCL2 CXCL8 TNF
9 mycobacterium tuberculosis 1 30.1 ADA NAT2 TLR2 TNF
10 endocarditis 30.1 CXCL8 TLR2 TNF
11 visceral leishmaniasis 30.0 CXCL8 TLR2 TNF
12 otitis media 30.0 CXCL8 TLR2 TNF
13 peritonitis 29.7 ADA CCL2 CXCL8 TLR2 TNF
14 arthritis 29.7 CCL2 CXCL8 MMP9 TGFB1 TNF
15 pleurisy 29.6 ADA ALOX5 CCL2 CXCL8 ENO2 TNF
16 neurosyphilis 29.6 CXCL8 TLR2
17 behcet syndrome 29.5 ADA CCL3 CXCL8 TNF
18 human immunodeficiency virus type 1 29.3 ADA ALOX5 CCL2 CCL3 TNF
19 pneumonia 29.2 CCL2 CCL3 CXCL8 TLR2 TNF
20 malaria 28.2 CCL2 CCL3 CXCL8 MMP9 TGFB1 TLR2
21 tuberculous peritonitis 11.2
22 bronchomalacia 11.1
23 hydrocephalus 10.7
24 congenital hydrocephalus 10.5
25 exudative glomerulonephritis 10.5 CXCL8 TNF
26 1,4-phenylenediamine allergic contact dermatitis 10.4 NAT2 TNF
27 autoimmune inner ear disease 10.4 MMP9 TNF
28 mycobacterium chelonae 10.4 CXCL8 TLR2
29 uveoparotid fever 10.4 LYZ TNF
30 herpes simplex virus keratitis 10.4 CCL2 CXCL8
31 congenital granular cell tumor 10.4 ENO2 LYZ
32 tungiasis 10.3 CXCL8 TNF
33 arachnoiditis 10.3
34 auditory system cancer 10.3 ENO2 LYZ
35 pyelonephritis 10.3 CCL2 CXCL8 TNF
36 periodontosis 10.3 CXCL8 MMP9 TNF
37 severe acute respiratory syndrome 10.3 CCL2 CXCL8 TNF
38 pyoderma 10.3 CXCL8 MMP9 TNF
39 vibratory urticaria 10.3 CXCL8 MMP9
40 bronchial disease 10.3 ALOX5 CXCL8 TNF
41 trench fever 10.3 TLR2 TNF
42 bronchiolitis obliterans 10.3 CXCL8 MMP9 TNF
43 alcoholic hepatitis 10.3 CCL2 CXCL8 TNF
44 allergic contact dermatitis 10.3 CXCL8 NAT2 TNF
45 syringomyelia 10.3
46 bone inflammation disease 10.3 CCL2 CXCL8 TNF
47 haemophilus influenzae 10.3 CXCL8 TLR2 TNF
48 mycobacterium abscessus 10.3 CXCL8 TLR2 TNF
49 mycobacterium kansasii 10.3 CXCL8 TLR2
50 middle ear disease 10.3 CXCL8 TLR2 TNF

Graphical network of the top 20 diseases related to Tuberculous Meningitis:



Diseases related to Tuberculous Meningitis

Symptoms & Phenotypes for Tuberculous Meningitis

MGI Mouse Phenotypes related to Tuberculous Meningitis:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ADA ALOX5 ENO2 GGT1 LYZ MMP9
2 cardiovascular system MP:0005385 10.15 ADA ALOX5 LYZ MMP9 NPPA TGFB1
3 immune system MP:0005387 10.14 ADA ALOX5 CCL2 GGT1 LTA4H LYZ
4 hematopoietic system MP:0005397 10.13 ADA ALOX5 GGT1 LYZ MMP9 NPPA
5 digestive/alimentary MP:0005381 10 ADA LYZ MMP9 TGFB1 TLR2 TNF
6 muscle MP:0005369 9.91 ADA MMP9 NPPA TGFB1 TLR2 TNF
7 renal/urinary system MP:0005367 9.86 ADA GGT1 LYZ MMP9 NPPA TGFB1
8 neoplasm MP:0002006 9.8 LYZ MMP9 TGFB1 TLR2 TNF VEGFA
9 reproductive system MP:0005389 9.76 ADA GGT1 LYZ MMP9 NAT2 TGFB1
10 respiratory system MP:0005388 9.56 ADA ENO2 LYZ MMP9 TGFB1 TLR2
11 skeleton MP:0005390 9.28 ADA ALOX5 GGT1 LYZ MMP9 TGFB1

Drugs & Therapeutics for Tuberculous Meningitis

Drugs for Tuberculous Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
3 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
4 BB 1101 Phase 4,Phase 2,Phase 3
5 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
6 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
7 Antiemetics Phase 4,Phase 2,Phase 3
8 glucocorticoids Phase 4,Phase 2,Phase 3
9 Autonomic Agents Phase 4,Phase 2,Phase 3
10 Hormone Antagonists Phase 4,Phase 2,Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
12
protease inhibitors Phase 4,Phase 2,Phase 3
13 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
14 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
15 Hormones Phase 4,Phase 2,Phase 3
16
Ethambutol Approved Phase 2, Phase 3,Phase 1 74-55-5 14052 3279
17
Rifampicin Approved Phase 2, Phase 3,Phase 1 13292-46-1 5381226 5458213
18
Pyrazinamide Approved, Investigational Phase 2, Phase 3,Phase 1 98-96-4 1046
19
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 65-23-6 1054
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
21 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3,Phase 1,Not Applicable
22 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Not Applicable
23 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 1,Not Applicable
24 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
25 Vitamin B9 Phase 2, Phase 3
26 Antitubercular Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
27 Trace Elements Phase 2, Phase 3
28 Folate Phase 2, Phase 3
29 Nutrients Phase 2, Phase 3
30 Micronutrients Phase 2, Phase 3
31 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1,Not Applicable
32 Vitamin B Complex Phase 2, Phase 3
33 Vitamins Phase 2, Phase 3
34 Vitamin B 6 Phase 2, Phase 3
35 Liver Extracts Phase 3
36
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3 66-72-8 1050
37
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
38
Norgestimate Approved, Investigational Phase 2 35189-28-7 6540478
39
Polyestradiol phosphate Approved Phase 2 28014-46-2
40
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
41
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
42
Moxifloxacin Approved, Investigational Phase 2 354812-41-2, 151096-09-2 152946
43
Isoniazid Approved, Investigational Phase 1, Phase 2,Phase 2,Not Applicable 54-85-3 3767
44
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
45
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
46
Linezolid Approved, Investigational Phase 2 165800-03-3 441401
47
BCG vaccine Investigational Phase 2
48 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2,Not Applicable
49 Analgesics Phase 2
50 Anti-Inflammatory Agents, Non-Steroidal Phase 2

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
2 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
3 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
4 Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Recruiting NCT03092817 Phase 3 Dexamethasone
5 Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Recruiting NCT03100786 Phase 3 Dexamethasone
6 A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis Completed NCT02237365 Phase 2 81mg aspirin;1000mg aspirin;Placebo
7 Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Completed NCT01802502 Phase 2 Rifampicin intravenous;Oral rifampicin
8 Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study Completed NCT01158755 Phase 2 Moxifloxacin
9 Safety and Immunogenicity of MVA85A Prime and Bacille Calmette-Guerin Boost Vaccination Completed NCT01650389 Phase 2
10 Optimizing Treatment to Improve TBM Outcomes in Children Recruiting NCT02958709 Phase 1, Phase 2 High-dose: RIF, INH, PZA, EMB;High dose: RIF, INH, PZA, LEVO;Standard of care: RIF, INH, PZA, EMB
11 Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM Not yet recruiting NCT03927313 Phase 2 Linezolid;High dose rifampicin;Aspirin;Standard of Care anti-tuberculous therapy;Dexamethasone
12 Pharmacokinetic Study of Linezolid for TB Meningitis Not yet recruiting NCT03537495 Phase 2 Linezolid
13 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
14 Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Unknown status NCT00433719 Not Applicable Combivir and efavirenz
15 Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF Completed NCT01371916
16 Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone Completed NCT01317654
17 Meningitis With Cerebral Vasculitis in Children Completed NCT03595761
18 Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis Recruiting NCT03898635 Linezolid
19 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
20 Diagnostics and Pharmacotherapy for Severe Forms of TB (DMID 15-0100) Enrolling by invitation NCT03559582
21 Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis Not yet recruiting NCT03787940 Not Applicable Isoniazid

Search NIH Clinical Center for Tuberculous Meningitis

Genetic Tests for Tuberculous Meningitis

Anatomical Context for Tuberculous Meningitis

MalaCards organs/tissues related to Tuberculous Meningitis:

42
Testes, Brain, Spinal Cord, T Cells, Pituitary, Endothelial, Neutrophil

Publications for Tuberculous Meningitis

Articles related to Tuberculous Meningitis:

(show top 50) (show all 2144)
# Title Authors Year
1
Complications of tuberculous meningitis in magnetic resonance imaging in a patient with systemic lupus erythematosus. ( 31103223 )
2019
2
A systematic review and meta-analysis of the diagnostic accuracy of nucleic acid amplification tests in cerebrospinal fluid for tuberculous meningitis. ( 30944198 )
2019
3
Dynamic prediction of death in patients with tuberculous meningitis using time-updated Glasgow coma score and plasma sodium measurements. ( 30944929 )
2019
4
Role of Oxidative Stress in Tuberculous Meningitis: a Clinico-Radiological Correlation. ( 30976988 )
2019
5
Structural switching electrochemical DNA aptasensor for the rapid diagnosis of tuberculous meningitis. ( 30988611 )
2019
6
Acute ischemic stroke in young adults with tuberculous meningitis. ( 31039747 )
2019
7
Tuberculous meningitis: A neglected tropical disease? ( 31041130 )
2019
8
Attainment of Target Rifampin Concentrations in Cerebrospinal Fluid during Treatment of Tuberculous Meningitis. ( 31051278 )
2019
9
Intracranial Artery Injury in HIV-negative Tuberculous Meningitis : A High-Resolution Vessel Wall Imaging Study. ( 31053877 )
2019
10
Comments on magnetic resonance venographic findings in patients with tuberculous meningitis: Predictors and outcome. ( 31071472 )
2019
11
Prevailing practices in the treatment of tuberculous meningitis (TBM): a cross-sectional study. ( 31085623 )
2019
12
Cerebral hemiatrophy: A delayed sequalae of multidrug-resistant tuberculous meningitis. ( 31085899 )
2019
13
The neurocritical care of tuberculous meningitis. ( 31109897 )
2019
14
Paradoxical reaction in HIV-negative tuberculous meningitis patients with spinal involvement. ( 30529369 )
2019
15
Global shortages of BCG vaccine and tuberculous meningitis in children. ( 30554756 )
2019
16
Mortality in hospitalized patients with tuberculous meningitis. ( 30611205 )
2019
17
A Child with Tuberculous Meningitis Complicated by Cortical Venous and Cerebral Sino-Venous Thrombosis. ( 30623313 )
2019
18
The pathogenesis of tuberculous meningitis. ( 30645042 )
2019
19
Grading tuberculous meningitis. ( 30649228 )
2019
20
Immune cell characteristics and cytokine responses in adult HIV-negative tuberculous meningitis: an observational cohort study. ( 30696839 )
2019
21
Ophthalmological manifestation in patients of tuberculous meningitis. ( 30722057 )
2019
22
Multidrug-resistant tuberculous meningitis in a returned traveller. ( 30746823 )
2019
23
Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis. ( 30753686 )
2019
24
A Simple Microfluidic Assay for Diagnosing Tuberculous Meningitis in HIV-Uninfected Patients. ( 30814264 )
2019
25
Leptomeningeal leukaemia misdiagnosed as tubercular meningitis. ( 30842137 )
2019
26
Validation of Mycobacterium tuberculosis real-time polymerase chain reaction for diagnosis of tuberculous meningitis using cerebrospinal fluid samples: a pilot study. ( 30267625 )
2019
27
Pretreatment Cerebrospinal Fluid Bacterial Load Correlates With Inflammatory Response and Predicts Neurological Events During Tuberculous Meningitis Treatment. ( 30299487 )
2019
28
Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis. ( 30159215 )
2018
29
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
30
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
31
Diagnostic scoring system for tuberculous meningitis among adult patients with non-suppurative and non-bacterial meningitis. ( 29705393 )
2018
32
Chiari malformation and tuberculous meningitis: aetiology and management. ( 29622715 )
2018
33
Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults. ( 30182032 )
2018
34
A study of atrial and brain natriuretic peptides in tuberculous meningitis and acute encephalitis. ( 29562995 )
2018
35
Tuberculous Meningitis during Chemotherapy for Advanced Gastric Cancer. ( 29805373 )
2018
36
A Randomized Study Comparing Endoscopic Third Ventriculostomy versus Ventriculoperitoneal Shunt in the Management of Hydrocephalus Due to Tuberculous Meningitis. ( 30459883 )
2018
37
Correlation of Lactate Concentration in Peripheral Plasma and Cerebrospinal Fluid with Glasgow Outcome Scale for Patients with Tuberculous Meningitis Complicated by Acute Hydrocephalus Treated with Fluid Diversions. ( 29248780 )
2018
38
Case Report: Three's a crowd: a case report examining the diagnostic and pharmacokinetic challenges in HIV-tuberculous meningitis-malaria co-infection. ( 30687789 )
2018
39
Pediatric Tubercular Meningitis: A Review. ( 30937075 )
2018
40
Tuberculous meningitis: Challenges in diagnosis and management: Lessons learnt from Prof. Dastur's article published in 1970. ( 30504541 )
2018
41
Does adjunctive corticosteroid and aspirin therapy improve the outcome of tuberculous meningitis? ( 30504561 )
2018
42
Role of aspirin as an adjuvant therapy in tuberculous meningitis in adults: The time has come for a phase III randomized controlled trial. ( 30504562 )
2018
43
Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis. ( 30518610 )
2018
44
Corticosteroid-dependent tuberculous meningitis: A case report. ( 30522040 )
2018
45
Computed tomography thorax abnormalities in immunocompetent patients with tuberculous meningitis: An observational study. ( 30554051 )
2018
46
Tuberculous Meningitis, Vasculitis, and Pericarditis presented by deep coma. ( 30559826 )
2018
47
High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study). ( 30175245 )
2018
48
Generation and application of DNA aptamers against HspX for accurate diagnosis of tuberculous meningitis. ( 30205966 )
2018
49
Tuberculous meningitis diagnosis and treatment in adults: A series of 189 suspected cases. ( 30210618 )
2018
50
Improving the microbiological diagnosis of tuberculous meningitis: A prospective, international, multicentre comparison of conventional and modified Ziehl-Neelsen stain, GeneXpert, and culture of cerebrospinal fluid. ( 30217659 )
2018

Variations for Tuberculous Meningitis

Expression for Tuberculous Meningitis

Search GEO for disease gene expression data for Tuberculous Meningitis.

Pathways for Tuberculous Meningitis

Pathways related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2
Show member pathways
13.3 ALOX5 CCL2 CCL3 CXCL8 MMP9 TGFB1
3
Show member pathways
13.02 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
4
Show member pathways
12.83 CCL2 CCL3 CXCL8 MMP9 TGFB1 TLR2
5
Show member pathways
12.28 ALOX5 CCL2 GGT1 TNF
6
Show member pathways
12.28 CCL2 CXCL8 MMP9 TLR2 TNF
7 12.24 MMP9 TGFB1 TLR2 TNF VEGFA
8
Show member pathways
12.21 ALOX5 TGFB1 TLR2 TNF
9
Show member pathways
12.16 CCL2 CCL3 CXCL8 MMP9 TLR2
10 12.11 MMP9 TGFB1 TLR2 TNF VEGFA
11 12.04 CCL2 MMP9 TNF VEGFA
12 11.89 CCL2 MMP9 TNF
13 11.88 CCL2 CXCL8 MMP9 TGFB1 TNF
14 11.87 CCL3 CXCL8 TGFB1
15 11.85 ENO2 NPPA VEGFA
16 11.84 CXCL8 TGFB1 TLR2 TNF
17 11.78 CCL2 MMP9 TGFB1
18 11.77 CCL2 CXCL8 TGFB1 TNF VEGFA
19 11.69 CXCL8 MMP9 VEGFA
20 11.63 MMP9 TGFB1 VEGFA
21
Show member pathways
11.61 CXCL8 MMP9 TNF VEGFA
22 11.57 CCL2 CCL3 MMP9 TGFB1 TNF
23 11.56 ALOX5 CCL2 CXCL8 MMP9 TGFB1 TNF
24 11.54 CXCL8 TLR2 TNF
25 11.5 CXCL8 TGFB1 VEGFA
26 11.47 CCL2 CCL3 CXCL8 TNF
27 11.46 CCL2 TLR2 TNF
28 11.43 CCL2 CCL3 CXCL8 MMP9 TGFB1 TNF
29 11.34 CCL2 CXCL8 TGFB1 TLR2 TNF
30 11.3 CCL2 CXCL8 MMP9
31 11.15 CCL2 CCL3 CXCL8 TNF
32 11.15 CCL2 MMP9 TLR2
33 11.13 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
34 11.12 ALOX5 GGT1 LTA4H
35 10.96 CCL2 CCL3 CXCL8 TGFB1 TNF
36 10.9 CCL2 CCL3 TNF
37 10.81 TGFB1 TNF
38 10.54 ALOX5 GGT1 LTA4H

GO Terms for Tuberculous Meningitis

Cellular components related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2 cell surface GO:0009986 9.65 ADA TGFB1 TLR2 TNF VEGFA
3 extracellular space GO:0005615 9.47 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2
4 tertiary granule lumen GO:1904724 9.33 LTA4H LYZ MMP9

Biological processes related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.99 ALOX5 LTA4H LYZ MMP9 TLR2
2 positive regulation of gene expression GO:0010628 9.97 CCL3 MIR29A TGFB1 TLR2 TNF VEGFA
3 negative regulation of gene expression GO:0010629 9.93 CCL3 MIR29A TGFB1 TNF VEGFA
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 CCL2 CCL3 TGFB1 TNF
5 positive regulation of cell migration GO:0030335 9.91 CCL3 MIR29A MMP9 TGFB1 VEGFA
6 MAPK cascade GO:0000165 9.9 CCL2 CCL3 TGFB1 TNF
7 positive regulation of protein phosphorylation GO:0001934 9.87 MMP9 TGFB1 TNF VEGFA
8 regulation of signaling receptor activity GO:0010469 9.87 CCL2 CCL3 CXCL8 NPPA TGFB1 TNF
9 positive regulation of protein kinase B signaling GO:0051897 9.86 CCL3 MIR29A TGFB1 TNF
10 cellular response to interferon-gamma GO:0071346 9.84 CCL2 CCL3 TLR2
11 defense response to Gram-positive bacterium GO:0050830 9.84 LYZ TLR2 TNF
12 response to hypoxia GO:0001666 9.83 ADA NPPA TGFB1 TLR2 VEGFA
13 neutrophil chemotaxis GO:0030593 9.82 CCL2 CCL3 CXCL8
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.82 TGFB1 TNF VEGFA
15 cellular response to interleukin-1 GO:0071347 9.81 CCL2 CCL3 CXCL8
16 positive regulation of inflammatory response GO:0050729 9.8 CCL3 TLR2 TNF
17 chemokine-mediated signaling pathway GO:0070098 9.78 CCL2 CCL3 CXCL8
18 positive regulation of MAP kinase activity GO:0043406 9.76 TGFB1 TNF VEGFA
19 cellular response to organic cyclic compound GO:0071407 9.76 CCL2 CCL3 TGFB1 TNF
20 inflammatory response GO:0006954 9.76 ALOX5 CCL2 CCL3 CXCL8 LYZ TGFB1
21 positive regulation of protein complex assembly GO:0031334 9.7 TGFB1 TNF VEGFA
22 positive regulation of calcium ion import GO:0090280 9.68 CCL2 CCL3
23 negative regulation of phagocytosis GO:0050765 9.68 TGFB1 TLR2
24 induction of positive chemotaxis GO:0050930 9.67 CXCL8 VEGFA
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 CCL2 TLR2
26 protein kinase B signaling GO:0043491 9.67 CCL2 CCL3 TGFB1 TNF
27 macrophage chemotaxis GO:0048246 9.66 CCL2 CCL3
28 PERK-mediated unfolded protein response GO:0036499 9.65 CCL2 CXCL8
29 response to molecule of bacterial origin GO:0002237 9.65 CXCL8 TLR2
30 embryonic digestive tract development GO:0048566 9.65 ADA CXCL8 TNF
31 leukotriene biosynthetic process GO:0019370 9.64 ALOX5 LTA4H
32 response to cholesterol GO:0070723 9.62 CCL3 TGFB1
33 astrocyte cell migration GO:0043615 9.58 CCL2 CCL3
34 cell activation GO:0001775 9.58 CCL3 TGFB1 TLR2
35 leukotriene metabolic process GO:0006691 9.56 ALOX5 GGT1 LTA4H TLR2
36 positive regulation of mononuclear cell migration GO:0071677 9.55 TGFB1 TNF
37 lipopolysaccharide-mediated signaling pathway GO:0031663 9.35 CCL2 CCL3 TGFB1 TLR2 TNF
38 cytokine-mediated signaling pathway GO:0019221 9.23 ALOX5 CCL2 CCL3 CXCL8 MMP9 TGFB1
39 immune response GO:0006955 10.01 CCL2 CCL3 CXCL8 TLR2 TNF

Molecular functions related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 CCL3 LYZ MMP9 TGFB1 TLR2 TNF
2 chemokine activity GO:0008009 9.33 CCL2 CCL3 CXCL8
3 cytokine activity GO:0005125 9.1 CCL2 CCL3 CXCL8 TGFB1 TNF VEGFA
4 protein binding GO:0005515 10.16 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2

Sources for Tuberculous Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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