TBM
MCID: TBR011
MIFTS: 55

Tuberculous Meningitis (TBM)

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Tuberculous Meningitis

MalaCards integrated aliases for Tuberculous Meningitis:

Name: Tuberculous Meningitis 53 59
Tubercular Meningitis 53 59
Tuberculosis, Meningeal 73
Meningitis Tuberculous 55
Tb Meningitis 53
Tbm 59

Classifications:



External Ids:

Orphanet 59 ORPHA499004
ICD10 33 A17.0
UMLS 73 C0041318

Summaries for Tuberculous Meningitis

MalaCards based summary : Tuberculous Meningitis, also known as tubercular meningitis, is related to extrapulmonary tuberculosis and meningitis. An important gene associated with Tuberculous Meningitis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and spinal cord, and related phenotypes are cellular and cardiovascular system

Wikipedia : 76 Tuberculous meningitis is also known as TB meningitis or tubercular meningitis. Tuberculous meningitis... more...

Related Diseases for Tuberculous Meningitis

Diseases related to Tuberculous Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 253)
# Related Disease Score Top Affiliating Genes
1 extrapulmonary tuberculosis 32.5 ADA CCL2 TLR2
2 meningitis 31.3 ADA CCL2 CCL3 CXCL8 LYZ MMP9
3 miliary tuberculosis 31.0 ADA ENO2 TNF
4 bacterial meningitis 30.4 CXCL8 MMP9 TLR2 TNF
5 transverse myelitis 30.3 CXCL8 MMP9 TNF
6 mycobacterium marinum 30.2 CXCL8 TLR2
7 otitis media 30.2 CXCL8 TLR2 TNF
8 pulmonary tuberculosis 30.0 ADA CCL3 NAT2 TLR2 TNF
9 mycobacterium tuberculosis 1 30.0 ADA NAT2 TLR2 TNF
10 endocarditis 29.9 CXCL8 TLR2 TNF
11 visceral leishmaniasis 29.9 CXCL8 TLR2 TNF
12 pleurisy 29.6 ADA ALOX5 CCL2 CXCL8 ENO2 TNF
13 arthritis 29.6 CCL2 CXCL8 MMP9 TGFB1 TNF
14 leishmaniasis 29.6 CCL2 CXCL8 TGFB1 TLR2 TNF
15 neurosyphilis 29.6 CXCL8 TLR2
16 tracheobronchomalacia 12.3
17 tuberculous peritonitis 11.2
18 bronchomalacia 11.1
19 hydrocephalus 10.6
20 arachnoiditis 10.3
21 exudative glomerulonephritis 10.3 CXCL8 TNF
22 1,4-phenylenediamine allergic contact dermatitis 10.3 NAT2 TNF
23 uveoparotid fever 10.3 LYZ TNF
24 herpes simplex virus keratitis 10.2 CCL2 CXCL8
25 stroke, ischemic 10.2
26 syringomyelia 10.2
27 congenital granular cell tumor 10.2 ENO2 LYZ
28 autoimmune inner ear disease 10.2 MMP9 TNF
29 interstitial nephritis 10.2
30 tungiasis 10.2 CXCL8 TNF
31 autoimmune myocarditis 10.2 NPPA TNF
32 mycobacterium chelonae 10.2 CXCL8 TLR2
33 auditory system cancer 10.2 ENO2 LYZ
34 pyelonephritis 10.2 CCL2 CXCL8 TNF
35 severe acute respiratory syndrome 10.2 CCL2 CXCL8 TNF
36 alcoholic hepatitis 10.2 CCL2 CXCL8 TNF
37 cystitis 10.2 CCL2 CXCL8 TNF
38 bone inflammation disease 10.2 CCL2 CXCL8 TNF
39 bronchial disease 10.2 ALOX5 CXCL8 TNF
40 pulmonary edema 10.2 CXCL8 NPPA TNF
41 allergic contact dermatitis 10.2 CXCL8 NAT2 TNF
42 periodontosis 10.2 CXCL8 MMP9 TNF
43 human immunodeficiency virus infectious disease 10.2
44 scleritis 10.2 CCL2 MMP9 TNF
45 vibratory urticaria 10.2 CXCL8 MMP9
46 trench fever 10.2 TLR2 TNF
47 clonorchiasis 10.2 CXCL8 TGFB1 TNF
48 bronchiolitis obliterans 10.2 CXCL8 MMP9 TNF
49 mycobacterium kansasii 10.2 CXCL8 TLR2
50 streptococcal toxic-shock syndrome 10.2 CXCL8 TNF

Graphical network of the top 20 diseases related to Tuberculous Meningitis:



Diseases related to Tuberculous Meningitis

Symptoms & Phenotypes for Tuberculous Meningitis

MGI Mouse Phenotypes related to Tuberculous Meningitis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ADA ALOX5 ENO2 GGT1 LYZ MMP9
2 cardiovascular system MP:0005385 10.15 ADA ALOX5 LYZ MMP9 NPPA TGFB1
3 immune system MP:0005387 10.14 ADA ALOX5 CCL2 GGT1 LTA4H LYZ
4 hematopoietic system MP:0005397 10.13 ADA ALOX5 GGT1 LYZ MMP9 NPPA
5 digestive/alimentary MP:0005381 10 ADA LYZ MMP9 TGFB1 TLR2 TNF
6 muscle MP:0005369 9.91 ADA MMP9 NPPA TGFB1 TLR2 TNF
7 renal/urinary system MP:0005367 9.86 ADA GGT1 LYZ MMP9 NPPA TGFB1
8 neoplasm MP:0002006 9.8 LYZ MMP9 TGFB1 TLR2 TNF VEGFA
9 reproductive system MP:0005389 9.76 ADA GGT1 LYZ MMP9 NAT2 TGFB1
10 respiratory system MP:0005388 9.56 ADA ENO2 LYZ MMP9 TGFB1 TLR2
11 skeleton MP:0005390 9.28 ADA ALOX5 GGT1 LYZ MMP9 TGFB1

Drugs & Therapeutics for Tuberculous Meningitis

Drugs for Tuberculous Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 1177-87-3
3 Hormone Antagonists Phase 4,Phase 2,Phase 3
4 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
5 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
6 Autonomic Agents Phase 4,Phase 2,Phase 3
7 Hormones Phase 4,Phase 2,Phase 3
8 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
9 Antiemetics Phase 4,Phase 2,Phase 3
10 BB 1101 Phase 4,Phase 2,Phase 3
11 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
12
protease inhibitors Phase 4,Phase 2,Phase 3
13 glucocorticoids Phase 4,Phase 2,Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
15 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
16
Ethambutol Approved Phase 2, Phase 3,Phase 1 74-55-5 3279 14052
17
Rifampicin Approved Phase 2, Phase 3,Phase 1 13292-46-1 5458213 5381226
18
Pyrazinamide Approved, Investigational Phase 2, Phase 3,Phase 1 98-96-4 1046
19
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 65-23-6 1054
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
21 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 1,Not Applicable
22 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Not Applicable
23 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3,Phase 1,Not Applicable
24 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
25 Vitamin B Complex Phase 2, Phase 3
26 Trace Elements Phase 2, Phase 3
27 Vitamins Phase 2, Phase 3
28 Vitamin B9 Phase 2, Phase 3
29 Micronutrients Phase 2, Phase 3
30 Folate Phase 2, Phase 3
31 Vitamin B 6 Phase 2, Phase 3
32 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
33 Antitubercular Agents Phase 2, Phase 3,Phase 3,Phase 1
34 Liver Extracts Phase 3
35
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3 66-72-8 1050
36
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
37
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
38 Estradiol valerate Approved, Investigational, Vet_approved Phase 2 979-32-8
39
Polyestradiol phosphate Approved Phase 2 28014-46-2
40
Moxifloxacin Approved, Investigational Phase 2 354812-41-2, 151096-09-2 152946
41
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
42
Norgestimate Approved, Investigational Phase 2 35189-28-7 6540478
43
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
44
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
45
Isoniazid Approved, Investigational Phase 1, Phase 2,Phase 2 54-85-3 3767
46
Linezolid Approved, Investigational Phase 2 165800-03-3 441401
47
BCG vaccine Investigational Phase 2
48 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2,Not Applicable
49 Analgesics Phase 2
50 Fibrinolytic Agents Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
2 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
3 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
4 Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Recruiting NCT03092817 Phase 3 Dexamethasone
5 Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Recruiting NCT03100786 Phase 3 Dexamethasone
6 A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis Completed NCT02237365 Phase 2 81mg aspirin;1000mg aspirin;Placebo
7 Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Completed NCT01802502 Phase 2 Rifampicin intravenous;Oral rifampicin
8 Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study Completed NCT01158755 Phase 2 Moxifloxacin
9 Safety and Immunogenicity of MVA85A Prime and Bacille Calmette-Guerin Boost Vaccination Completed NCT01650389 Phase 2
10 Optimizing Treatment to Improve TBM Outcomes in Children Recruiting NCT02958709 Phase 1, Phase 2 High-dose: RIF, INH, PZA, EMB;High dose: RIF, INH, PZA, LEVO;Standard of care: RIF, INH, PZA, EMB
11 Pharmacokinetic Study of Linezolid for TB Meningitis Not yet recruiting NCT03537495 Phase 2 Linezolid
12 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
13 Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Unknown status NCT00433719 Not Applicable Combivir and efavirenz
14 Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF Completed NCT01371916
15 Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone Completed NCT01317654
16 Meningitis With Cerebral Vasculitis in Children Completed NCT03595761
17 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
18 Diagnostics and Pharmacotherapy for Severe Forms of TB (DMID 15-0100) Enrolling by invitation NCT03559582
19 Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis Not yet recruiting NCT03787940 Not Applicable Isoniazid

Search NIH Clinical Center for Tuberculous Meningitis

Genetic Tests for Tuberculous Meningitis

Anatomical Context for Tuberculous Meningitis

MalaCards organs/tissues related to Tuberculous Meningitis:

41
Testes, Brain, Spinal Cord, Liver, T Cells, Lung, Bone

Publications for Tuberculous Meningitis

Articles related to Tuberculous Meningitis:

(show top 50) (show all 1162)
# Title Authors Year
1
Global shortages of BCG vaccine and tuberculous meningitis in children. ( 30554756 )
2019
2
Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. ( 29395996 )
2018
3
Paradoxical Reaction in a Patient with Co-Occurring Tuberculous Meningitis and Pott's Disease. ( 29907737 )
2018
4
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
5
Diagnosis of tuberculous meningitis with invasive pulmonary sampling. ( 29303733 )
2018
6
Development of a clinical prediction rule for tuberculous meningitis in adults in Lima, Peru. ( 29446860 )
2018
7
Use of Linezolid in a Child With Tuberculous Meningitis. ( 29652742 )
2018
8
Absence of cerebrospinal fluid pleocytosis in tuberculous meningitis is a common occurrence in HIV co-infection and a predictor of poor outcomes. ( 29391245 )
2018
9
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
10
A study of atrial and brain natriuretic peptides in tuberculous meningitis and acute encephalitis. ( 29562995 )
2018
11
Microbiological diagnosis of adult tuberculous meningitis in a ten-year cohort in Indonesia. ( 29444749 )
2018
12
Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome. ( 29297432 )
2018
13
Xpert MTB/RIF<sup>Ar</sup> assay for the diagnosis of HIV-related tuberculous meningitis in SALo Paulo, Brazil. ( 29862958 )
2018
14
Diagnostic accuracy of nucleic acid amplification based assays for tuberculous meningitis: A meta-analysis. ( 29758242 )
2018
15
Diagnostic test accuracy of adenosine deaminase for tuberculous meningitis: A systematic review and meta-analysis - An update. ( 29807089 )
2018
16
Diffuse Leptomeningeal Glioneural Tumour Simulating Tuberculous Meningitis in a 13-Year-Old Girl. ( 29301133 )
2018
17
Comparative whole-genome sequence analysis of Mycobacterium tuberculosis isolated from tuberculous meningitis and pulmonary tuberculosis patients. ( 29559684 )
2018
18
Mycobacterium marinum Infection in Zebrafish and Microglia Imitates the Early Stage of Tuberculous Meningitis. ( 29352446 )
2018
19
CSF protein concentration associated with ventriculoperitoneal shunt obstruction in tuberculous meningitis. ( 29914605 )
2018
20
Diagnostic scoring system for tuberculous meningitis among adult patients with non-suppurative and non-bacterial meningitis. ( 29705393 )
2018
21
Predicting mortality of tuberculous meningitis. ( 29860408 )
2018
22
Tuberculous Meningitis during Chemotherapy for Advanced Gastric Cancer. ( 29805373 )
2018
23
Late-onset paradoxical reactions 10A years after treatment for tuberculous meningitis in an HIV-negative patient: a case report. ( 29980175 )
2018
24
Progress on Diagnosis of Tuberculous Meningitis. ( 29536453 )
2018
25
Tuberculous meningitis is associated with higher cerebrospinal HIV-1 viral loads compared to other HIV-1-associated meningitides. ( 29394269 )
2018
26
Is drug-induced hepatitis related to the severity of tuberculous meningitis? ( 29438557 )
2018
27
Expression of autophagy-related genes in cerebrospinal fluid of patients with tuberculous meningitis. ( 29805485 )
2018
28
Correction: optic disc swelling in a patient with tuberculous meningitis: a diagnostic challenge. ( 29348273 )
2018
29
Could omics unlock the secret of surviving tuberculous meningitis? ( 29398390 )
2018
30
Isoniazid and rifampicin heteroresistant Mycobacterium tuberculosis isolated from tuberculous meningitis patients in India. ( 29332649 )
2018
31
Tuberculous meningitis: a roadmap for advancing basic and translational research. ( 29777209 )
2018
32
Chiari malformation and tuberculous meningitis: aetiology and management. ( 29622715 )
2018
33
Evaluation of the GeneXpert MTB/RIF in patients with presumptive tuberculous meningitis. ( 29912907 )
2018
34
Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis. ( 30159215 )
2018
35
Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults. ( 30182032 )
2018
36
A Randomized Study Comparing Endoscopic Third Ventriculostomy versus Ventriculoperitoneal Shunt in the Management of Hydrocephalus Due to Tuberculous Meningitis. ( 30459883 )
2018
37
Diagnostic accuracy of cerebrospinal fluid adenosine deaminase in detecting Tuberculous Meningitis. ( 30344579 )
2018
38
Frequency and Impact of Cerebral Infarctions in Patients With Tuberculous Meningitis. ( 30355085 )
2018
39
Management of complex tuberculosis cases: a focus on drug-resistant tuberculous meningitis. ( 30359140 )
2018
40
Adjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST ACT): Study protocol for a randomised double blind placebo controlled non-inferiority trial. ( 30363837 )
2018
41
Seizures in tuberculous meningitis. ( 30396007 )
2018
42
Rupture of a Middle Meningeal Artery Pseudoaneurysm in Moyamoya Syndrome Related with Tuberculous Meningitis. ( 30397591 )
2018
43
Intensified antibiotic treatment of tuberculous meningitis. ( 30474434 )
2018
44
Cerebrospinal Fluid Lactate in Tubercular Meningitis: Diagnostic or Prognostic Marker. ( 30477060 )
2018
45
Tuberculous meningitis: Challenges in diagnosis and management: Lessons learnt from Prof. Dastur's article published in 1970. ( 30504541 )
2018
46
Does adjunctive corticosteroid and aspirin therapy improve the outcome of tuberculous meningitis? ( 30504561 )
2018
47
Role of aspirin as an adjuvant therapy in tuberculous meningitis in adults: The time has come for a phase III randomized controlled trial. ( 30504562 )
2018
48
Comparative evaluation of Xpert MTB/RIF assay with multiplex polymerase chain reaction for the diagnosis of tuberculous meningitis. ( 30514512 )
2018
49
Noninvasive 11C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis. ( 30518610 )
2018
50
Corticosteroid-dependent tuberculous meningitis: A case report. ( 30522040 )
2018

Variations for Tuberculous Meningitis

Expression for Tuberculous Meningitis

Search GEO for disease gene expression data for Tuberculous Meningitis.

Pathways for Tuberculous Meningitis

Pathways related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2
Show member pathways
13.3 ALOX5 CCL2 CCL3 CXCL8 MMP9 TGFB1
3
Show member pathways
12.94 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
4
Show member pathways
12.92 CCL2 CCL3 CXCL8 MMP9 TGFB1 TLR2
5
Show member pathways
12.28 ALOX5 CCL2 GGT1 TNF
6
Show member pathways
12.28 CCL2 CXCL8 MMP9 TLR2 TNF
7 12.24 MMP9 TGFB1 TLR2 TNF VEGFA
8
Show member pathways
12.21 ALOX5 TGFB1 TLR2 TNF
9
Show member pathways
12.16 CCL2 CCL3 CXCL8 MMP9 TLR2
10 12.11 MMP9 TGFB1 TLR2 TNF VEGFA
11 12.04 CCL2 MMP9 TNF VEGFA
12 11.89 CCL2 MMP9 TNF
13 11.88 CCL2 CXCL8 MMP9 TGFB1 TNF
14 11.87 CCL3 CXCL8 TGFB1
15 11.85 ENO2 NPPA VEGFA
16 11.84 CXCL8 TGFB1 TLR2 TNF
17 11.78 CCL2 MMP9 TGFB1
18 11.76 CCL2 CXCL8 TGFB1 TNF VEGFA
19 11.69 CXCL8 MMP9 VEGFA
20 11.63 MMP9 TGFB1 VEGFA
21
Show member pathways
11.61 CXCL8 MMP9 TNF VEGFA
22 11.57 CCL2 CCL3 MMP9 TGFB1 TNF
23 11.56 ALOX5 CCL2 CXCL8 MMP9 TGFB1 TNF
24 11.54 CXCL8 TLR2 TNF
25 11.5 CXCL8 TGFB1 VEGFA
26 11.47 CCL2 CCL3 CXCL8 TNF
27 11.46 CCL2 TLR2 TNF
28 11.43 CCL2 CCL3 CXCL8 MMP9 TGFB1 TNF
29 11.34 CCL2 CXCL8 TGFB1 TLR2 TNF
30 11.3 CCL2 CXCL8 MMP9
31 11.15 CCL2 CCL3 CXCL8 TNF
32 11.15 CCL2 MMP9 TLR2
33 11.12 ALOX5 GGT1 LTA4H
34 11.12 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
35 10.96 CCL2 CCL3 CXCL8 TGFB1 TNF
36 10.9 CCL2 CCL3 TNF
37 10.81 TGFB1 TNF
38 10.54 ALOX5 GGT1 LTA4H

GO Terms for Tuberculous Meningitis

Cellular components related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2 cell surface GO:0009986 9.65 ADA TGFB1 TLR2 TNF VEGFA
3 extracellular space GO:0005615 9.47 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2
4 tertiary granule lumen GO:1904724 9.33 LTA4H LYZ MMP9

Biological processes related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.99 ALOX5 LTA4H LYZ MMP9 TLR2
2 positive regulation of gene expression GO:0010628 9.97 CCL3 MIR29A TGFB1 TLR2 TNF VEGFA
3 negative regulation of gene expression GO:0010629 9.93 CCL3 MIR29A TGFB1 TNF VEGFA
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 CCL2 CCL3 TGFB1 TNF
5 positive regulation of cell migration GO:0030335 9.91 CCL3 MIR29A MMP9 TGFB1 VEGFA
6 regulation of signaling receptor activity GO:0010469 9.91 CCL2 CCL3 CXCL8 NPPA TGFB1 TNF
7 MAPK cascade GO:0000165 9.9 CCL2 CCL3 TGFB1 TNF
8 positive regulation of protein phosphorylation GO:0001934 9.87 MMP9 TGFB1 TNF VEGFA
9 positive regulation of protein kinase B signaling GO:0051897 9.86 CCL3 MIR29A TGFB1 TNF
10 cellular response to interferon-gamma GO:0071346 9.84 CCL2 CCL3 TLR2
11 defense response to Gram-positive bacterium GO:0050830 9.84 LYZ TLR2 TNF
12 response to hypoxia GO:0001666 9.83 ADA NPPA TGFB1 TLR2 VEGFA
13 neutrophil chemotaxis GO:0030593 9.82 CCL2 CCL3 CXCL8
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.82 TGFB1 TNF VEGFA
15 cellular response to interleukin-1 GO:0071347 9.81 CCL2 CCL3 CXCL8
16 positive regulation of inflammatory response GO:0050729 9.8 CCL3 TLR2 TNF
17 chemokine-mediated signaling pathway GO:0070098 9.78 CCL2 CCL3 CXCL8
18 positive regulation of MAP kinase activity GO:0043406 9.76 TGFB1 TNF VEGFA
19 cellular response to organic cyclic compound GO:0071407 9.76 CCL2 CCL3 TGFB1 TNF
20 inflammatory response GO:0006954 9.76 ALOX5 CCL2 CCL3 CXCL8 LYZ TGFB1
21 positive regulation of protein complex assembly GO:0031334 9.7 TGFB1 TNF VEGFA
22 positive regulation of calcium ion import GO:0090280 9.68 CCL2 CCL3
23 negative regulation of phagocytosis GO:0050765 9.68 TGFB1 TLR2
24 induction of positive chemotaxis GO:0050930 9.67 CXCL8 VEGFA
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 CCL2 TLR2
26 macrophage chemotaxis GO:0048246 9.66 CCL2 CCL3
27 PERK-mediated unfolded protein response GO:0036499 9.65 CCL2 CXCL8
28 response to molecule of bacterial origin GO:0002237 9.65 CXCL8 TLR2
29 embryonic digestive tract development GO:0048566 9.65 ADA CXCL8 TNF
30 leukotriene biosynthetic process GO:0019370 9.64 ALOX5 LTA4H
31 response to cholesterol GO:0070723 9.62 CCL3 TGFB1
32 protein kinase B signaling GO:0043491 9.62 CCL2 CCL3 TGFB1 TNF
33 astrocyte cell migration GO:0043615 9.58 CCL2 CCL3
34 cell activation GO:0001775 9.58 CCL3 TGFB1 TLR2
35 leukotriene metabolic process GO:0006691 9.56 ALOX5 GGT1 LTA4H TLR2
36 positive regulation of mononuclear cell migration GO:0071677 9.55 TGFB1 TNF
37 lipopolysaccharide-mediated signaling pathway GO:0031663 9.35 CCL2 CCL3 TGFB1 TLR2 TNF
38 cytokine-mediated signaling pathway GO:0019221 9.23 ALOX5 CCL2 CCL3 CXCL8 MMP9 TGFB1
39 immune response GO:0006955 10.01 CCL2 CCL3 CXCL8 TLR2 TNF

Molecular functions related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 CCL3 LYZ MMP9 TGFB1 TLR2 TNF
2 chemokine activity GO:0008009 9.33 CCL2 CCL3 CXCL8
3 cytokine activity GO:0005125 9.1 CCL2 CCL3 CXCL8 TGFB1 TNF VEGFA
4 protein binding GO:0005515 10.16 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2

Sources for Tuberculous Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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