TBM
MCID: TBR011
MIFTS: 55

Tuberculous Meningitis (TBM)

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Tuberculous Meningitis

MalaCards integrated aliases for Tuberculous Meningitis:

Name: Tuberculous Meningitis 54 60
Tubercular Meningitis 54 60
Tuberculosis, Meningeal 74
Meningitis Tuberculous 56
Tb Meningitis 54
Tbm 60

Classifications:



External Ids:

ICD10 34 A17.0
Orphanet 60 ORPHA499004
UMLS 74 C0041318

Summaries for Tuberculous Meningitis

MalaCards based summary : Tuberculous Meningitis, also known as tubercular meningitis, is related to extrapulmonary tuberculosis and miliary tuberculosis. An important gene associated with Tuberculous Meningitis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and spinal cord, and related phenotypes are cellular and cardiovascular system

Wikipedia : 77 Tuberculous meningitis is also known as TB meningitis or tubercular meningitis. Tuberculous meningitis... more...

Related Diseases for Tuberculous Meningitis

Diseases related to Tuberculous Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 extrapulmonary tuberculosis 32.7 ADA CCL2 TLR2
2 miliary tuberculosis 31.2 ADA ENO2 TNF
3 meningitis 30.9 ADA CCL2 CCL3 CXCL8 LYZ MMP9
4 bacterial meningitis 30.5 CXCL8 MMP9 TLR2 TNF
5 transverse myelitis 30.5 CXCL8 MMP9 TNF
6 mycobacterium marinum 30.4 CXCL8 TLR2
7 cystitis 30.1 CCL2 CXCL8 TNF
8 mycobacterium tuberculosis 1 30.0 ADA NAT2 TLR2 TNF
9 endocarditis 30.0 CXCL8 TLR2 TNF
10 pulmonary tuberculosis 30.0 ADA CCL3 NAT2 TLR2 TNF
11 visceral leishmaniasis 30.0 CXCL8 TLR2 TNF
12 otitis media 29.9 CXCL8 TLR2 TNF
13 arthritis 29.6 CCL2 CXCL8 MMP9 TGFB1 TNF
14 pleurisy 29.6 ADA ALOX5 CCL2 CXCL8 ENO2 TNF
15 neurosyphilis 29.5 CXCL8 TLR2
16 pneumonia 29.1 CCL2 CCL3 CXCL8 TLR2 TNF
17 malaria 28.3 CCL2 CCL3 CXCL8 MMP9 TGFB1 TLR2
18 tracheobronchomalacia 12.3
19 tuberculous peritonitis 11.2
20 bronchomalacia 11.1
21 hydrocephalus 10.7
22 exudative glomerulonephritis 10.5 CXCL8 TNF
23 autoimmune inner ear disease 10.4 MMP9 TNF
24 herpes simplex virus keratitis 10.4 CCL2 CXCL8
25 uveoparotid fever 10.4 LYZ TNF
26 tungiasis 10.3 CXCL8 TNF
27 congenital granular cell tumor 10.3 ENO2 LYZ
28 mycobacterium chelonae 10.3 CXCL8 TLR2
29 1,4-phenylenediamine allergic contact dermatitis 10.3 NAT2 TNF
30 large cell carcinoma with rhabdoid phenotype 10.3 ENO2 VEGFA
31 pyelonephritis 10.3 CCL2 CXCL8 TNF
32 severe acute respiratory syndrome 10.3 CCL2 CXCL8 TNF
33 arachnoiditis 10.3
34 periodontosis 10.3 CXCL8 MMP9 TNF
35 pyoderma 10.3 CXCL8 MMP9 TNF
36 vibratory urticaria 10.3 CXCL8 MMP9
37 auditory system cancer 10.3 ENO2 LYZ
38 alcoholic hepatitis 10.3 CCL2 CXCL8 TNF
39 bronchiolitis obliterans 10.3 CXCL8 MMP9 TNF
40 bone inflammation disease 10.3 CCL2 CXCL8 TNF
41 bronchial disease 10.3 ALOX5 CXCL8 TNF
42 syringomyelia 10.3
43 pulmonary edema 10.3 CXCL8 NPPA TNF
44 macular holes 10.3 CCL2 CXCL8 VEGFA
45 clonorchiasis 10.3 CXCL8 TGFB1 TNF
46 angiokeratoma circumscriptum 10.3 MMP9 VEGFA
47 trench fever 10.3 TLR2 TNF
48 prostatitis 10.3 CXCL8 TGFB1 TNF
49 interstitial nephritis 10.3
50 haemophilus influenzae 10.3 CXCL8 TLR2 TNF

Graphical network of the top 20 diseases related to Tuberculous Meningitis:



Diseases related to Tuberculous Meningitis

Symptoms & Phenotypes for Tuberculous Meningitis

MGI Mouse Phenotypes related to Tuberculous Meningitis:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 ADA ALOX5 ENO2 GGT1 LYZ MMP9
2 cardiovascular system MP:0005385 10.15 ADA ALOX5 LYZ MMP9 NPPA TGFB1
3 immune system MP:0005387 10.14 ADA ALOX5 CCL2 GGT1 LTA4H LYZ
4 hematopoietic system MP:0005397 10.13 ADA ALOX5 GGT1 LYZ MMP9 NPPA
5 digestive/alimentary MP:0005381 10 ADA LYZ MMP9 TGFB1 TLR2 TNF
6 muscle MP:0005369 9.91 ADA MMP9 NPPA TGFB1 TLR2 TNF
7 renal/urinary system MP:0005367 9.86 ADA GGT1 LYZ MMP9 NPPA TGFB1
8 neoplasm MP:0002006 9.8 LYZ MMP9 TGFB1 TLR2 TNF VEGFA
9 reproductive system MP:0005389 9.76 ADA GGT1 LYZ MMP9 NAT2 TGFB1
10 respiratory system MP:0005388 9.56 ADA ENO2 LYZ MMP9 TGFB1 TLR2
11 skeleton MP:0005390 9.28 ADA ALOX5 GGT1 LYZ MMP9 TGFB1

Drugs & Therapeutics for Tuberculous Meningitis

Drugs for Tuberculous Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
3 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
4 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
5 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
6 Hormones Phase 4,Phase 2,Phase 3
7
protease inhibitors Phase 4,Phase 2,Phase 3
8 Autonomic Agents Phase 4,Phase 2,Phase 3
9 BB 1101 Phase 4,Phase 2,Phase 3
10 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
11 Hormone Antagonists Phase 4,Phase 2,Phase 3
12 Antiemetics Phase 4,Phase 2,Phase 3
13 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
14 glucocorticoids Phase 4,Phase 2,Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
16
Pyrazinamide Approved, Investigational Phase 2, Phase 3,Phase 1 98-96-4 1046
17
Rifampicin Approved Phase 2, Phase 3,Phase 1 13292-46-1 5381226 5458213
18
Ethambutol Approved Phase 2, Phase 3,Phase 1 74-55-5 3279 14052
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
20
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 65-23-6 1054
21 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 1,Not Applicable
22 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3,Phase 1,Not Applicable
23 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Not Applicable
24 Vitamin B 6 Phase 2, Phase 3
25 Antitubercular Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
26 Vitamin B9 Phase 2, Phase 3
27 Folate Phase 2, Phase 3
28 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
29 Micronutrients Phase 2, Phase 3
30 Nutrients Phase 2, Phase 3
31 Vitamin B Complex Phase 2, Phase 3
32 Trace Elements Phase 2, Phase 3
33 Vitamins Phase 2, Phase 3
34 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1,Not Applicable
35 Liver Extracts Phase 3
36
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3 66-72-8 1050
37
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
38
Moxifloxacin Approved, Investigational Phase 2 354812-41-2, 151096-09-2 152946
39
Norgestimate Approved, Investigational Phase 2 35189-28-7 6540478
40
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
41
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
42
Polyestradiol phosphate Approved Phase 2 28014-46-2
43
Isoniazid Approved, Investigational Phase 1, Phase 2,Phase 2,Not Applicable 54-85-3 3767
44
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
45
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
46
Linezolid Approved, Investigational Phase 2 165800-03-3 441401
47
BCG vaccine Investigational Phase 2
48 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2,Not Applicable
49 Analgesics Phase 2
50 Platelet Aggregation Inhibitors Phase 2

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
2 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
3 Treatment Duration for Abdominal Tuberculosis Completed NCT01124929 Phase 3 RNTCP Category I treatment for 6 months;RNTCP Category I treatment for 9months
4 Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Recruiting NCT03092817 Phase 3 Dexamethasone
5 Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Recruiting NCT03100786 Phase 3 Dexamethasone
6 A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis Completed NCT02237365 Phase 2 81mg aspirin;1000mg aspirin;Placebo
7 Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Completed NCT01802502 Phase 2 Rifampicin intravenous;Oral rifampicin
8 Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study Completed NCT01158755 Phase 2 Moxifloxacin
9 Safety and Immunogenicity of MVA85A Prime and Bacille Calmette-Guerin Boost Vaccination Completed NCT01650389 Phase 2
10 Optimizing Treatment to Improve TBM Outcomes in Children Recruiting NCT02958709 Phase 1, Phase 2 High-dose: RIF, INH, PZA, EMB;High dose: RIF, INH, PZA, LEVO;Standard of care: RIF, INH, PZA, EMB
11 Pharmacokinetic Study of Linezolid for TB Meningitis Not yet recruiting NCT03537495 Phase 2 Linezolid
12 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
13 Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Unknown status NCT00433719 Not Applicable Combivir and efavirenz
14 Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF Completed NCT01371916
15 Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone Completed NCT01317654
16 Meningitis With Cerebral Vasculitis in Children Completed NCT03595761
17 Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis Recruiting NCT03898635 Linezolid
18 Driving Reduced AIDS-associated Meningo-encephalitis Mortality Recruiting NCT03226379
19 Diagnostics and Pharmacotherapy for Severe Forms of TB (DMID 15-0100) Enrolling by invitation NCT03559582
20 Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis Not yet recruiting NCT03787940 Not Applicable Isoniazid

Search NIH Clinical Center for Tuberculous Meningitis

Genetic Tests for Tuberculous Meningitis

Anatomical Context for Tuberculous Meningitis

MalaCards organs/tissues related to Tuberculous Meningitis:

42
Testes, Brain, Spinal Cord, T Cells, Bone, Endothelial, Neutrophil

Publications for Tuberculous Meningitis

Articles related to Tuberculous Meningitis:

(show top 50) (show all 2123)
# Title Authors Year
1
A Child with Tuberculous Meningitis Complicated by Cortical Venous and Cerebral Sino-Venous Thrombosis. ( 30623313 )
2019
2
The pathogenesis of tuberculous meningitis. ( 30645042 )
2019
3
Grading tuberculous meningitis. ( 30649228 )
2019
4
Immune cell characteristics and cytokine responses in adult HIV-negative tuberculous meningitis: an observational cohort study. ( 30696839 )
2019
5
Ophthalmological manifestation in patients of tuberculous meningitis. ( 30722057 )
2019
6
Multidrug-resistant tuberculous meningitis in a returned traveller. ( 30746823 )
2019
7
Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis. ( 30753686 )
2019
8
A simple microfluidic assay for diagnosing tuberculous meningitis in HIV-uninfected patients. ( 30814264 )
2019
9
Leptomeningeal leukaemia misdiagnosed as tubercular meningitis. ( 30842137 )
2019
10
Global shortages of BCG vaccine and tuberculous meningitis in children. ( 30554756 )
2019
11
Mortality in hospitalized patients with tuberculous meningitis. ( 30611205 )
2019
12
Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. ( 29395996 )
2018
13
Paradoxical Reaction in a Patient with Co-Occurring Tuberculous Meningitis and Pott's Disease. ( 29907737 )
2018
14
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
15
Diagnosis of tuberculous meningitis with invasive pulmonary sampling. ( 29303733 )
2018
16
Development of a clinical prediction rule for tuberculous meningitis in adults in Lima, Peru. ( 29446860 )
2018
17
Use of Linezolid in a Child With Tuberculous Meningitis. ( 29652742 )
2018
18
Absence of cerebrospinal fluid pleocytosis in tuberculous meningitis is a common occurrence in HIV co-infection and a predictor of poor outcomes. ( 29391245 )
2018
19
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
20
A study of atrial and brain natriuretic peptides in tuberculous meningitis and acute encephalitis. ( 29562995 )
2018
21
Microbiological diagnosis of adult tuberculous meningitis in a ten-year cohort in Indonesia. ( 29444749 )
2018
22
Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome. ( 29297432 )
2018
23
Xpert MTB/RIF<sup>Ar</sup> assay for the diagnosis of HIV-related tuberculous meningitis in SALo Paulo, Brazil. ( 29862958 )
2018
24
Diagnostic accuracy of nucleic acid amplification based assays for tuberculous meningitis: A meta-analysis. ( 29758242 )
2018
25
Diagnostic test accuracy of adenosine deaminase for tuberculous meningitis: A systematic review and meta-analysis - An update. ( 29807089 )
2018
26
Diffuse Leptomeningeal Glioneural Tumour Simulating Tuberculous Meningitis in a 13-Year-Old Girl. ( 29301133 )
2018
27
Comparative whole-genome sequence analysis of Mycobacterium tuberculosis isolated from tuberculous meningitis and pulmonary tuberculosis patients. ( 29559684 )
2018
28
Mycobacterium marinum Infection in Zebrafish and Microglia Imitates the Early Stage of Tuberculous Meningitis. ( 29352446 )
2018
29
CSF protein concentration associated with ventriculoperitoneal shunt obstruction in tuberculous meningitis. ( 29914605 )
2018
30
Diagnostic scoring system for tuberculous meningitis among adult patients with non-suppurative and non-bacterial meningitis. ( 29705393 )
2018
31
Predicting mortality of tuberculous meningitis. ( 29860408 )
2018
32
Tuberculous Meningitis during Chemotherapy for Advanced Gastric Cancer. ( 29805373 )
2018
33
Late-onset paradoxical reactions 10A years after treatment for tuberculous meningitis in an HIV-negative patient: a case report. ( 29980175 )
2018
34
Progress on Diagnosis of Tuberculous Meningitis. ( 29536453 )
2018
35
Tuberculous meningitis is associated with higher cerebrospinal HIV-1 viral loads compared to other HIV-1-associated meningitides. ( 29394269 )
2018
36
Is drug-induced hepatitis related to the severity of tuberculous meningitis? ( 29438557 )
2018
37
Expression of autophagy-related genes in cerebrospinal fluid of patients with tuberculous meningitis. ( 29805485 )
2018
38
Correction: optic disc swelling in a patient with tuberculous meningitis: a diagnostic challenge. ( 29348273 )
2018
39
Could omics unlock the secret of surviving tuberculous meningitis? ( 29398390 )
2018
40
Isoniazid and rifampicin heteroresistant Mycobacterium tuberculosis isolated from tuberculous meningitis patients in India. ( 29332649 )
2018
41
Tuberculous meningitis: a roadmap for advancing basic and translational research. ( 29777209 )
2018
42
Chiari malformation and tuberculous meningitis: aetiology and management. ( 29622715 )
2018
43
Evaluation of the GeneXpert MTB/RIF in patients with presumptive tuberculous meningitis. ( 29912907 )
2018
44
Clinical presentations and outcomes of the children with tuberculous meningitis: An experience at a tertiary care hospital. ( 29371710 )
2018
45
Human immunodeficiency virus in patients with tuberculous meningitis: systematic review and meta-analysis. ( 29660820 )
2018
46
Hypovolemia due to cerebral salt wasting may contribute to stroke in tuberculous meningitis. ( 29635544 )
2018
47
Neuromarker Levels Also Predict Mortality in Adult Tuberculous Meningitis. ( 29617975 )
2018
48
Conduction Aphasia as Initial Manifestation of Tuberculous Meningitis. ( 30159215 )
2018
49
Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults. ( 30182032 )
2018
50
A Randomized Study Comparing Endoscopic Third Ventriculostomy versus Ventriculoperitoneal Shunt in the Management of Hydrocephalus Due to Tuberculous Meningitis. ( 30459883 )
2018

Variations for Tuberculous Meningitis

Expression for Tuberculous Meningitis

Search GEO for disease gene expression data for Tuberculous Meningitis.

Pathways for Tuberculous Meningitis

Pathways related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2
Show member pathways
13.3 ALOX5 CCL2 CCL3 CXCL8 MMP9 TGFB1
3
Show member pathways
13.11 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
4
Show member pathways
12.83 CCL2 CCL3 CXCL8 MMP9 TGFB1 TLR2
5
Show member pathways
12.28 ALOX5 CCL2 GGT1 TNF
6
Show member pathways
12.28 CCL2 CXCL8 MMP9 TLR2 TNF
7 12.24 MMP9 TGFB1 TLR2 TNF VEGFA
8
Show member pathways
12.21 ALOX5 TGFB1 TLR2 TNF
9
Show member pathways
12.16 CCL2 CCL3 CXCL8 MMP9 TLR2
10 12.11 MMP9 TGFB1 TLR2 TNF VEGFA
11 12.04 CCL2 MMP9 TNF VEGFA
12 11.89 CCL2 MMP9 TNF
13 11.88 CCL2 CXCL8 MMP9 TGFB1 TNF
14 11.87 CCL3 CXCL8 TGFB1
15 11.85 ENO2 NPPA VEGFA
16 11.84 CXCL8 TGFB1 TLR2 TNF
17 11.78 CCL2 MMP9 TGFB1
18 11.77 CCL2 CXCL8 TGFB1 TNF VEGFA
19 11.69 CXCL8 MMP9 VEGFA
20 11.63 MMP9 TGFB1 VEGFA
21
Show member pathways
11.61 CXCL8 MMP9 TNF VEGFA
22 11.57 CCL2 CCL3 MMP9 TGFB1 TNF
23 11.56 ALOX5 CCL2 CXCL8 MMP9 TGFB1 TNF
24 11.54 CXCL8 TLR2 TNF
25 11.5 CXCL8 TGFB1 VEGFA
26 11.47 CCL2 CCL3 CXCL8 TNF
27 11.46 CCL2 TLR2 TNF
28 11.43 CCL2 CCL3 CXCL8 MMP9 TGFB1 TNF
29 11.34 CCL2 CXCL8 TGFB1 TLR2 TNF
30 11.3 CCL2 CXCL8 MMP9
31 11.15 CCL2 CCL3 CXCL8 TNF
32 11.15 CCL2 MMP9 TLR2
33 11.13 CCL2 CCL3 CXCL8 TGFB1 TLR2 TNF
34 11.12 ALOX5 GGT1 LTA4H
35 10.96 CCL2 CCL3 CXCL8 TGFB1 TNF
36 10.9 CCL2 CCL3 TNF
37 10.81 TGFB1 TNF
38 10.54 ALOX5 GGT1 LTA4H

GO Terms for Tuberculous Meningitis

Cellular components related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ALOX5 CCL2 CCL3 CXCL8 LTA4H LYZ
2 cell surface GO:0009986 9.65 ADA TGFB1 TLR2 TNF VEGFA
3 extracellular space GO:0005615 9.47 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2
4 tertiary granule lumen GO:1904724 9.33 LTA4H LYZ MMP9

Biological processes related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.99 ALOX5 LTA4H LYZ MMP9 TLR2
2 positive regulation of gene expression GO:0010628 9.97 CCL3 MIR29A TGFB1 TLR2 TNF VEGFA
3 negative regulation of gene expression GO:0010629 9.93 CCL3 MIR29A TGFB1 TNF VEGFA
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 CCL2 CCL3 TGFB1 TNF
5 positive regulation of cell migration GO:0030335 9.91 CCL3 MIR29A MMP9 TGFB1 VEGFA
6 MAPK cascade GO:0000165 9.9 CCL2 CCL3 TGFB1 TNF
7 positive regulation of protein phosphorylation GO:0001934 9.87 MMP9 TGFB1 TNF VEGFA
8 regulation of signaling receptor activity GO:0010469 9.87 CCL2 CCL3 CXCL8 NPPA TGFB1 TNF
9 positive regulation of protein kinase B signaling GO:0051897 9.86 CCL3 MIR29A TGFB1 TNF
10 cellular response to interferon-gamma GO:0071346 9.84 CCL2 CCL3 TLR2
11 defense response to Gram-positive bacterium GO:0050830 9.84 LYZ TLR2 TNF
12 response to hypoxia GO:0001666 9.83 ADA NPPA TGFB1 TLR2 VEGFA
13 neutrophil chemotaxis GO:0030593 9.82 CCL2 CCL3 CXCL8
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.82 TGFB1 TNF VEGFA
15 cellular response to interleukin-1 GO:0071347 9.81 CCL2 CCL3 CXCL8
16 positive regulation of inflammatory response GO:0050729 9.8 CCL3 TLR2 TNF
17 chemokine-mediated signaling pathway GO:0070098 9.78 CCL2 CCL3 CXCL8
18 positive regulation of MAP kinase activity GO:0043406 9.76 TGFB1 TNF VEGFA
19 cellular response to organic cyclic compound GO:0071407 9.76 CCL2 CCL3 TGFB1 TNF
20 inflammatory response GO:0006954 9.76 ALOX5 CCL2 CCL3 CXCL8 LYZ TGFB1
21 positive regulation of protein complex assembly GO:0031334 9.7 TGFB1 TNF VEGFA
22 positive regulation of calcium ion import GO:0090280 9.68 CCL2 CCL3
23 negative regulation of phagocytosis GO:0050765 9.68 TGFB1 TLR2
24 induction of positive chemotaxis GO:0050930 9.67 CXCL8 VEGFA
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 CCL2 TLR2
26 protein kinase B signaling GO:0043491 9.67 CCL2 CCL3 TGFB1 TNF
27 macrophage chemotaxis GO:0048246 9.66 CCL2 CCL3
28 PERK-mediated unfolded protein response GO:0036499 9.65 CCL2 CXCL8
29 response to molecule of bacterial origin GO:0002237 9.65 CXCL8 TLR2
30 embryonic digestive tract development GO:0048566 9.65 ADA CXCL8 TNF
31 leukotriene biosynthetic process GO:0019370 9.64 ALOX5 LTA4H
32 response to cholesterol GO:0070723 9.62 CCL3 TGFB1
33 astrocyte cell migration GO:0043615 9.58 CCL2 CCL3
34 cell activation GO:0001775 9.58 CCL3 TGFB1 TLR2
35 leukotriene metabolic process GO:0006691 9.56 ALOX5 GGT1 LTA4H TLR2
36 positive regulation of mononuclear cell migration GO:0071677 9.55 TGFB1 TNF
37 lipopolysaccharide-mediated signaling pathway GO:0031663 9.35 CCL2 CCL3 TGFB1 TLR2 TNF
38 cytokine-mediated signaling pathway GO:0019221 9.23 ALOX5 CCL2 CCL3 CXCL8 MMP9 TGFB1
39 immune response GO:0006955 10.01 CCL2 CCL3 CXCL8 TLR2 TNF

Molecular functions related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 CCL3 LYZ MMP9 TGFB1 TLR2 TNF
2 chemokine activity GO:0008009 9.33 CCL2 CCL3 CXCL8
3 cytokine activity GO:0005125 9.1 CCL2 CCL3 CXCL8 TGFB1 TNF VEGFA
4 protein binding GO:0005515 10.16 ADA ALOX5 CCL2 CCL3 CXCL8 ENO2

Sources for Tuberculous Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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