TBM
MCID: TBR011
MIFTS: 48

Tuberculous Meningitis (TBM)

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Tuberculous Meningitis

MalaCards integrated aliases for Tuberculous Meningitis:

Name: Tuberculous Meningitis 20 58 32
Tubercular Meningitis 20 58
Tuberculosis, Meningeal 70
Meningitis Tuberculous 54
Tb Meningitis 20
Tbm 58

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare infectious diseases


External Ids:

ICD10 32 A17.0
Orphanet 58 ORPHA499004
UMLS 70 C0041318

Summaries for Tuberculous Meningitis

MalaCards based summary : Tuberculous Meningitis, also known as tubercular meningitis, is related to extrapulmonary tuberculosis and miliary tuberculosis. An important gene associated with Tuberculous Meningitis is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, pituitary and eye, and related phenotypes are cellular and immune system

Wikipedia : 73 Tuberculous meningitis is also known as TB meningitis or tubercular meningitis. Tuberculous meningitis... more...

Related Diseases for Tuberculous Meningitis

Diseases related to Tuberculous Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 650)
# Related Disease Score Top Affiliating Genes
1 extrapulmonary tuberculosis 32.2 TLR2 CCL2 ADA
2 miliary tuberculosis 31.6 TNF ENO2 ADA
3 viral meningitis 31.3 CXCL8 CCL2 ADA
4 central nervous system tuberculosis 31.2 TNF MMP9 ADA
5 aseptic meningitis 31.2 TNF CXCL8 CCL3 ADA
6 meningitis 31.1 VEGFA TNF TLR2 MMP9 LYZ LTA4H
7 encephalitis 31.0 TNF TLR2 CCL3 CCL2
8 hydrocephalus 31.0 VEGFA TNF TGFB1 ENO2
9 bacterial meningitis 31.0 TNF TLR2 MMP9 CXCL8 CCL2
10 pulmonary tuberculosis 30.9 TNF TLR2 NAT2 CCL3 CCL2 ADA
11 myelitis 30.8 TNF MMP9 CXCL8
12 fungal meningitis 30.8 TNF CXCL8 CCL3
13 neurosyphilis 30.7 TLR2 CXCL8
14 mycobacterium tuberculosis 1 30.6 TNF TLR2 NAT2 CCL3 ADA
15 mycobacterium marinum 30.6 TLR2 CXCL8
16 sarcoidosis 1 30.6 TNF CCL3 CCL2 ADA
17 immune deficiency disease 30.5 TNF TLR2 CCL3 CCL2 ADA
18 transverse myelitis 30.4 TNF MMP9 CXCL8
19 endometritis 30.4 TNF TLR2 CXCL8
20 pericarditis 30.4 TNF ENO2 CXCL8 ADA
21 mycobacterium kansasii 30.3 TLR2 CXCL8
22 otitis media 30.3 TNF TLR2 CXCL8
23 congenital cytomegalovirus 30.3 TNF TLR2 CCL2
24 haemophilus influenzae 30.2 TNF TLR2 CXCL8
25 paracoccidioidomycosis 30.2 TNF TLR2 CXCL8
26 bronchopneumonia 30.2 TNF CXCL8 CCL3
27 exanthem 30.2 VEGFA TNF CXCL8
28 optic neuritis 30.2 VEGFA TNF CXCL8
29 endocarditis 30.1 TNF TLR2 CXCL8
30 toxic shock syndrome 30.1 TNF TLR2 CXCL8
31 visceral leishmaniasis 30.1 TNF TLR2 CXCL8 ADA
32 bacterial infectious disease 30.0 TNF TLR2 CXCL8 CCL3 CCL2
33 viral encephalitis 30.0 VEGFA TNF CXCL8 CCL2
34 central nervous system disease 30.0 TNF MMP9 MIR29A CCL2
35 toxoplasmosis 30.0 TNF TLR2 TGFB1 CCL3
36 gastroenteritis 30.0 TNF MMP9 CXCL8
37 juvenile rheumatoid arthritis 30.0 TNF CXCL8 CCL2
38 candidiasis 29.9 TNF TLR2 CXCL8
39 pleural tuberculosis 29.9 TNF CXCL8 CCL3 CCL2 ADA
40 kawasaki disease 29.9 TNF MMP9 CCL2
41 brucellosis 29.8 TNF TGFB1 CXCL8 ADA
42 pulmonary edema 29.8 TNF NPPA CXCL8
43 pneumonia 29.8 TNF TLR2 CXCL8 CCL3 CCL2
44 cystitis 29.8 VEGFA TNF CXCL8 CCL2
45 human immunodeficiency virus type 1 29.8 TNF CCL3 CCL2 ALOX5 ADA
46 rheumatic heart disease 29.7 TNF TLR2 TGFB1
47 viral hepatitis 29.7 TNF TLR2 TGFB1 GGT1
48 pericardial effusion 29.6 VEGFA NPPA ADA
49 peritonitis 29.6 TNF TLR2 CXCL8 CCL3 CCL2 ADA
50 secondary progressive multiple sclerosis 29.6 VEGFA MMP9 ENO2 CCL2

Graphical network of the top 20 diseases related to Tuberculous Meningitis:



Diseases related to Tuberculous Meningitis

Symptoms & Phenotypes for Tuberculous Meningitis

MGI Mouse Phenotypes related to Tuberculous Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.17 ADA ALOX5 ENO2 GGT1 LYZ MMP9
2 immune system MP:0005387 10.11 ADA ALOX5 CCL2 GGT1 LTA4H LYZ
3 digestive/alimentary MP:0005381 9.95 ADA LYZ MMP9 TGFB1 TLR2 TNF
4 muscle MP:0005369 9.92 ADA LYZ MMP9 NPPA TGFB1 TLR2
5 renal/urinary system MP:0005367 9.86 ADA GGT1 LYZ MMP9 NPPA TGFB1
6 reproductive system MP:0005389 9.81 ADA GGT1 LYZ MMP9 NAT2 NELL2
7 respiratory system MP:0005388 9.56 ADA ENO2 LYZ MMP9 TGFB1 TLR2
8 skeleton MP:0005390 9.28 ADA ALOX5 GGT1 LYZ MMP9 TGFB1

Drugs & Therapeutics for Tuberculous Meningitis

Drugs for Tuberculous Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3 Gastrointestinal Agents Phase 4
4 Antiemetics Phase 4
5 Hormone Antagonists Phase 4
6 glucocorticoids Phase 4
7 Hormones Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 Anti-Inflammatory Agents Phase 4
10
protease inhibitors Phase 4
11 BB 1101 Phase 4
12 HIV Protease Inhibitors Phase 4
13
Rifampicin Approved Phase 3 13292-46-1 5381226 5458213
14
Linezolid Approved, Investigational Phase 3 165800-03-3 441401
15
Pyrazinamide Approved, Investigational Phase 3 98-96-4 1046
16
Ethambutol Approved Phase 3 74-55-5 3279 14052
17
Isoniazid Approved, Investigational Phase 3 54-85-3 3767
18
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
19
Mesna Approved, Investigational Phase 2, Phase 3 3375-50-6 598
20
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
21
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 65-23-6 1054
22 Vitamin B 6 Phase 2, Phase 3
23 Antitubercular Agents Phase 3
24 Liver Extracts Phase 3
25 Analgesics, Non-Narcotic Phase 3
26 Fibrinolytic Agents Phase 3
27 Analgesics Phase 3
28 Cyclooxygenase Inhibitors Phase 3
29 Antipyretics Phase 3
30 Platelet Aggregation Inhibitors Phase 3
31 Anti-Inflammatory Agents, Non-Steroidal Phase 3
32 Antirheumatic Agents Phase 2, Phase 3
33 Immunosuppressive Agents Phase 2, Phase 3
34 Immunologic Factors Phase 2, Phase 3
35 Alkylating Agents Phase 2, Phase 3
36
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3 66-72-8 1050
37
Moxifloxacin Approved, Investigational Phase 2 354812-41-2, 151096-09-2 152946
38
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
39
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
40 Norgestimate, ethinyl estradiol drug combination Phase 2
41 Anti-Bacterial Agents Phase 2
42 Anti-Infective Agents Phase 2
43 Antibiotics, Antitubercular Phase 2
44
Zidovudine Approved 30516-87-1 35370
45
Lamivudine Approved, Investigational 134678-17-4 60825
46
Efavirenz Approved, Investigational 154598-52-4 64139
47 Reverse Transcriptase Inhibitors
48 Cytochrome P-450 Enzyme Inhibitors
49 Anti-Retroviral Agents
50 Antiviral Agents

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
2 A Randomized Double Blinded Phase 2b Clinical Trial Comparing Standard Dose With Two Higher Doses of Rifampicin for Treatment of Adults With Tuberculous Meningitis Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
3 A Randomized Double Blind Placebo Controlled Non-inferiority Trial of Adjunctive Dexamethasone for the Treatment of HIV-uninfected Adults With Tuberculous Meningitis Stratified by Leukotriene A4 Hydrolase Genotype Recruiting NCT03100786 Phase 3 Dexamethasone
4 A Randomized Double Blind Placebo Controlled Trial of Adjunctive Dexamethasone for the Treatment of HIV-infected Adults With Tuberculous Meningitis Recruiting NCT03092817 Phase 3 Dexamethasone
5 Intensified Tuberculosis Treatment to Reduce the Mortality of HIV-infected and Uninfected Patients With Tuberculosis Meningitis: a Phase III Randomized Controlled Trial (Acronym: INTENSE-TBM) Recruiting NCT04145258 Phase 3 Aspirin;Placebo of aspirin;WHO TBM treatment;Intensified TBM treatment
6 Efficacy and Safety of Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in Central Nervous System Tuberculosis- A Randomized Double Blinded Placebo Controlled Trial Not yet recruiting NCT04620772 Phase 2, Phase 3 Cyclophosphamide injection
7 Explorative PK Study Comparing 600 mg Rifampicin i.v. With 750 mg and 900 mg Rifampicin Oral in Tuberculous Meningitis Patients Completed NCT01802502 Phase 2 Rifampicin intravenous;Oral rifampicin
8 Comparison of Intensive Treatment Regimens and Standard Treatment Regimen for Tuberculous Meningitis: Pharmacokinetics, Pharmacodynamics and Tolerability Study Completed NCT01158755 Phase 2 Moxifloxacin
9 Phase I/II Randomized, Open-label Trial to Evaluate the PK, Safety, and Outcomes of Treatment Including High Dose Rifampicin +/- Levofloxacin vs Standard Treatment for Pediatric Tuberculous Meningitis (TBM) Completed NCT02958709 Phase 1, Phase 2 High-dose: RIF, INH, PZA, EMB;High dose: RIF, INH, PZA, LEVO;Standard of care: RIF, INH, PZA, EMB
10 A Pilot Phase II Randomized Controlled Double Blind Trial of 81mg Aspirin Daily vs. 1000 mg Aspirin Daily vs. Placebo as Adjunctive Therapy in HIV Negative Adults With Tuberculous Meningitis Completed NCT02237365 Phase 2 81mg aspirin;1000mg aspirin;Placebo
11 Phase IIA Trial of the Safety and Tolerability of Increased Dose Rifampicin and Adjunctive Linezolid With or Without Aspirin, for HIV-associated Tuberculous Meningitis Recruiting NCT03927313 Phase 2 Linezolid;High dose rifampicin;Aspirin;Standard of Care anti-tuberculous therapy;Dexamethasone
12 Short Intervention and Measurement of Pharmacokinetics of Linezolid in Tuberculosis Meningitis: a Pharmacokinetics and Safety/Tolerability Study Not yet recruiting NCT03537495 Phase 2 Linezolid
13 Pharmacokinetics and Tolerability of Adjunctive Linezolid for the Treatment of Tuberculous Meningitis Not yet recruiting NCT04021121 Phase 2 LZD;High dose RIF;Standard dose RIF
14 Randomised Controlled Trial of Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Unknown status NCT00433719 Combivir and efavirenz
15 Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis Unknown status NCT03898635 Linezolid
16 Diagnosis of Tuberculous Meningitis by a Secretory Antigenic Target 6 (ESAT-6) in CSF Completed NCT01371916
17 Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone Completed NCT01317654
18 Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis Based on N-Acetyltransferase Type 2 Genotyping Recruiting NCT03787940 Isoniazid
19 Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis Recruiting NCT04308928
20 Integrating the Diagnosis and Management of HIV-associated Central Nervous System (CNS) Infections Into Routine Health Services in Low and Middle Income Countries (LMICs) Recruiting NCT03226379

Search NIH Clinical Center for Tuberculous Meningitis

Genetic Tests for Tuberculous Meningitis

Anatomical Context for Tuberculous Meningitis

MalaCards organs/tissues related to Tuberculous Meningitis:

40
Spinal Cord, Pituitary, Eye, Liver, Lymph Node, Endothelial, T Cells

Publications for Tuberculous Meningitis

Articles related to Tuberculous Meningitis:

(show top 50) (show all 5578)
# Title Authors PMID Year
1
Comparative analysis of cerebrospinal fluid adenosine deaminase in tuberculous and non-tuberculous meningitis. 54 61
20399005 2010
2
To compare CSF adenosine deaminase levels and CSF-PCR for tuberculous meningitis. 54 61
20347212 2010
3
Adenosine deaminase and tuberculous meningitis--a systematic review with meta-analysis. 61 54
20001225 2010
4
[A case of listeria meningitis showed high levels of adenosine deaminase in cerebrospinal fluid]. 61 54
19928691 2009
5
Comparison of an adenosine deaminase assay with ELISA for the diagnosis of tuberculous meningitis infection. 54 61
17767115 2007
6
Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in adults. 61 54
17333738 2006
7
Cerebrospinal fluid adenosine deaminase activity: a complimentary tool in the early diagnosis of tuberculous meningitis. 61 54
16571142 2006
8
Cerebrospinal fluid adenosine deaminase levels and adverse neurological outcome in pediatric tuberculous meningitis. 61 54
16091897 2005
9
Adenosine deaminase activity in cerebrospinal fluid of HIV-infected patients: limited value for diagnosis of tuberculous meningitis. 61 54
15141333 2004
10
The possible role of cerebrospinal fluid adenosine deaminase activity in the diagnosis of tuberculous meningitis in adults. 54 61
11792470 2002
11
Shortfalls in the use of adenosine deaminase in tuberculous meningitis. 61 54
11444331 2001
12
Significance of cerebrospinal fluid adenosine deaminase isoenzymes in tuberculous (TB) meningitis. 54 61
11574950 2001
13
[Diagnosis of tuberculosis meningitis by detection of adenosine deaminase activity and amplification of nucleotide sequences with PCR]. 61 54
11899709 2001
14
[Treatment of tuberculous meningitis: marker of cure]. 54 61
9558655 1998
15
Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in children. 61 54
8699576 1996
16
[Usefulness of adenosine deaminase determination in cerebrospinal fluid for the diagnosis of meningeal tuberculosis: 4 years experience at a public hospital]. 61 54
9008944 1996
17
The use of adenosine deaminase activity as a biochemical marker for the diagnosis of tuberculous meningitis. 54 61
8935128 1995
18
Cerebrospinal fluid adenosine deaminase activity and C-reactive protein in tuberculous and partially treated bacterial meningitis. 54 61
8635832 1995
19
Adenosine deaminase activity in the CSF of patients with aseptic meningitis: utility in the diagnosis of tuberculous meningitis or neurobrucellosis. 61 54
7756471 1995
20
[Time-course of adenosine deaminase activity in the cerebrospinal fluid in patients with tuberculous meningitis]. 54 61
7837719 1994
21
[The activities of 3 enzymes in serum and cerebrospinal fluid for diagnosis of tuberculous meningitis]. 61 54
8403061 1993
22
[Adenosine deaminase. False negatives in tuberculous meningitis]. 54 61
1419094 1992
23
Atypical presentations of tuberculous meningitis--a case report. 54 61
1654188 1991
24
Diagnostic value of cerebrospinal fluid adenosine deaminase determination. 54 61
2028233 1991
25
The role of optic nerve sheath diameter ultrasound in brain infection. 61
33728383 2021
26
Eight-and-a-half syndrome caused by tuberculous meningitis: a case report. 61
33146815 2021
27
Value of next-generation sequencing in early diagnosis of patients with tuberculous meningitis. 61
33631643 2021
28
Is cerebral salt wasting related to sympathetic dysregulation in tuberculous meningitis? 61
33516801 2021
29
High-dose oral and intravenous rifampicin for the treatment of tuberculous meningitis in predominantly HIV-positive Ugandan adults: a phase II open-label randomised controlled trial. 61
33693537 2021
30
A comparison of the accuracy of the CapitalBio Mycobacterium real-time polymerase chain reaction and the Xpert MTB/RIF assay for the diagnosis of tuberculous meningitis. 61
33352329 2021
31
The impact of common Smurf1 gene variants on the risk, clinical characteristics and short-term prognosis of tuberculous meningitis. 61
33711518 2021
32
Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone. 61
33658385 2021
33
Meningitis as a recurrent manifestation of anti-AQP4/anti-MOG negative neuromyelitis optica spectrum disorder: a case report. 61
33750325 2021
34
Tuberculous meningitis mimicking Creutzfeldt-Jakob disease. 61
32747046 2021
35
Thalidomide Use for Complicated Central Nervous System Tuberculosis in Children: Insights From an Observational Cohort. 61
33283220 2021
36
Diagnostic accuracy of Xpert MTB/RIF for tuberculous meningitis: systematic review and meta-analysis. 61
33164243 2021
37
MR vessel wall imaging in tubercular meningitis. 61
33638692 2021
38
The protean manifestations of central nervous system IgG4-related hypertrophic pachymeningitis: a report of two cases. 61
33536053 2021
39
Clinical efficacy of metagenomic next-generation sequencing for rapid detection of Mycobacterium tuberculosis in smear-negative extrapulmonary specimens in a high tuberculosis burden area. 61
33227518 2021
40
Central nervous system tuberculosis. 61
33387702 2021
41
Cortical Venous Thrombosis Complicating Tubercular Meningitis. 61
33645195 2021
42
Evaluation of CSF pyrosequencing to diagnose tuberculous meningitis: A retrospective diagnostic accuracy study. 61
33421910 2021
43
Cerebrospinal fluid IL-1β is elevated in tuberculous meningitis patients but not associated with mortality. 61
33202351 2021
44
A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis. 61
33416499 2021
45
Tuberculous Meningitis Presenting as Cerebral Salt Wasting Syndrome: A Review of Literature with Clinical Approach to Hyponatremia. 61
33642300 2021
46
Use of Infliximab to Treat Paradoxical Tuberculous Meningitis Reactions. 61
33542942 2021
47
Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in a clinical practice setting of China. 61
33516988 2021
48
Fujifilm SILVAMP TB LAM assay on cerebrospinal fluid for the detection of tuberculous meningitis in HIV-infected adults. 61
33388751 2021
49
A novel bedside rule-in test for tuberculous meningitis in HIV-infected adults. 61
33403391 2021
50
Severe paradoxical reaction in tuberculous meningitis. 61
33299795 2021

Variations for Tuberculous Meningitis

Expression for Tuberculous Meningitis

Search GEO for disease gene expression data for Tuberculous Meningitis.

Pathways for Tuberculous Meningitis

Pathways related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 VEGFA TNF TLR2 TGFB1 MMP9 LYZ
2
Show member pathways
13.28 VEGFA TNF TGFB1 MMP9 CXCL8 CCL3
3
Show member pathways
13.14 TNF TLR2 TGFB1 MMP9 CXCL8 CCL3
4
Show member pathways
12.88 VEGFA TNF TLR2 CXCL8 CCL3 CCL2
5
Show member pathways
12.29 TNF CXCL8 CCL3 CCL2
6
Show member pathways
12.28 TNF GGT1 CCL2 ALOX5
7
Show member pathways
12.26 TNF TLR2 MMP9 CXCL8 CCL2
8 12.22 VEGFA TNF TLR2 TGFB1 MMP9
9
Show member pathways
12.2 TNF TLR2 TGFB1 ALOX5
10 12.07 VEGFA TNF TLR2 TGFB1 MMP9
11 12.04 VEGFA TNF MMP9 CCL2
12 11.86 TNF TLR2 TGFB1 CXCL8
13 11.85 TNF TGFB1 MMP9 CXCL8 CCL2
14 11.79 TGFB1 MMP9 CCL2
15
Show member pathways
11.72 TNF TLR2 TGFB1
16 11.72 VEGFA TNF TGFB1 CXCL8 CCL2
17 11.69 VEGFA MMP9 CXCL8
18 11.64 TNF TLR2 TGFB1
19 11.63 VEGFA TGFB1 MMP9
20
Show member pathways
11.58 VEGFA TNF MMP9 CXCL8
21 11.56 TNF TLR2 CXCL8
22 11.56 VEGFA TNF TGFB1 MMP9 CXCL8 CCL2
23 11.5 VEGFA TGFB1 CXCL8
24 11.47 TNF TLR2 CCL2
25 11.43 TNF TGFB1 MMP9 CXCL8 CCL3 CCL2
26 11.42 TNF CXCL8 CCL3 CCL2
27 11.35 TNF TLR2 TGFB1 CXCL8 CCL2
28
Show member pathways
11.32 TNF TGFB1 CCL3
29 11.28 MMP9 CXCL8 CCL2
30 11.14 VEGFA TNF TLR2 TGFB1 CXCL8 CCL3
31 11.13 TLR2 MMP9 CCL2
32 11.09 LTA4H GGT1 ALOX5
33 10.96 TNF TGFB1 CXCL8 CCL3 CCL2
34 10.87 TNF CCL3 CCL2
35 10.82 TNF TGFB1
36 10.48 LTA4H GGT1 ALOX5

GO Terms for Tuberculous Meningitis

Cellular components related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VEGFA TNF TGFB1 NPPA NELL2 MMP9
2 extracellular space GO:0005615 9.47 VEGFA TNF TGFB1 NPPA MMP9 MIR29A
3 tertiary granule lumen GO:1904724 9.33 MMP9 LYZ LTA4H

Biological processes related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.02 TNF TLR2 CXCL8 CCL3 CCL2
2 neutrophil degranulation GO:0043312 10 TLR2 MMP9 LYZ LTA4H ALOX5
3 MAPK cascade GO:0000165 9.97 TNF TGFB1 CCL3 CCL2
4 positive regulation of cell migration GO:0030335 9.93 VEGFA TGFB1 MMP9 MIR29A CCL3
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 VEGFA TNF TGFB1 CCL3 CCL2
6 positive regulation of gene expression GO:0010628 9.91 VEGFA TNF TLR2 TGFB1 MIR29A CXCL8
7 positive regulation of protein phosphorylation GO:0001934 9.9 VEGFA TNF TGFB1 MMP9
8 positive regulation of protein kinase B signaling GO:0051897 9.88 VEGFA TNF TGFB1 MIR29A CCL3
9 negative regulation of gene expression GO:0010629 9.88 VEGFA TNF TGFB1 MIR29A CXCL8 CCL3
10 cellular response to interferon-gamma GO:0071346 9.85 TLR2 CCL3 CCL2
11 positive regulation of inflammatory response GO:0050729 9.85 TNF TLR2 CCL3
12 response to hypoxia GO:0001666 9.85 VEGFA TLR2 TGFB1 NPPA ADA
13 regulation of inflammatory response GO:0050727 9.84 TNF GGT1 ALOX5
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 VEGFA TNF TGFB1
15 cellular response to interleukin-1 GO:0071347 9.81 CXCL8 CCL3 CCL2
16 neutrophil chemotaxis GO:0030593 9.8 CXCL8 CCL3 CCL2
17 cellular response to organic cyclic compound GO:0071407 9.8 TNF TGFB1 CCL3 CCL2
18 chemokine-mediated signaling pathway GO:0070098 9.79 CXCL8 CCL3 CCL2
19 positive regulation of MAP kinase activity GO:0043406 9.77 VEGFA TNF TGFB1
20 humoral immune response GO:0006959 9.76 TNF CCL2 ALOX5
21 inflammatory response GO:0006954 9.76 TNF TLR2 TGFB1 LYZ CXCL8 CCL3
22 positive regulation of protein complex assembly GO:0031334 9.74 VEGFA TNF TGFB1
23 embryonic digestive tract development GO:0048566 9.69 TNF CXCL8 ADA
24 macrophage chemotaxis GO:0048246 9.68 CCL3 CCL2
25 PERK-mediated unfolded protein response GO:0036499 9.67 CXCL8 CCL2
26 response to cholesterol GO:0070723 9.66 TGFB1 CCL3
27 surfactant homeostasis GO:0043129 9.66 VEGFA TGFB1
28 leukotriene biosynthetic process GO:0019370 9.65 LTA4H ALOX5
29 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.65 TNF TGFB1
30 positive regulation of vascular permeability GO:0043117 9.64 VEGFA TGFB1
31 response to molecule of bacterial origin GO:0002237 9.64 TLR2 CXCL8
32 negative regulation of vascular wound healing GO:0061044 9.62 TNF ALOX5
33 protein kinase B signaling GO:0043491 9.62 TNF TGFB1 CCL3 CCL2
34 cell activation GO:0001775 9.61 TLR2 TGFB1 CCL3
35 positive regulation of mononuclear cell migration GO:0071677 9.58 TNF TGFB1
36 astrocyte cell migration GO:0043615 9.56 CCL3 CCL2
37 leukotriene metabolic process GO:0006691 9.56 TLR2 LTA4H GGT1 ALOX5
38 positive regulation of leukocyte adhesion to arterial endothelial cell GO:1904999 9.55 TNF ALOX5
39 lipopolysaccharide-mediated signaling pathway GO:0031663 9.35 TNF TLR2 TGFB1 CCL3 CCL2
40 cytokine-mediated signaling pathway GO:0019221 9.23 VEGFA TNF TGFB1 MMP9 CXCL8 CCL3

Molecular functions related to Tuberculous Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.13 CXCL8 CCL3 CCL2
2 cytokine activity GO:0005125 9.1 VEGFA TNF TGFB1 CXCL8 CCL3 CCL2

Sources for Tuberculous Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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