MCID: TBL003
MIFTS: 42

Tubular Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Tubular Adenocarcinoma

MalaCards integrated aliases for Tubular Adenocarcinoma:

Name: Tubular Adenocarcinoma 12 15
Adenocarcinoma, Tubular 73
Adenocarcinoma Tubular 55
Tubular Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4929
MeSH 44 D000230
NCIt 50 C65192
SNOMED-CT 68 4631006
UMLS 73 C0205645

Summaries for Tubular Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.

MalaCards based summary : Tubular Adenocarcinoma, also known as adenocarcinoma, tubular, is related to gastric tubular adenocarcinoma and thymus adenocarcinoma. An important gene associated with Tubular Adenocarcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways are Pathways in cancer and Glioma. The drugs Gemcitabine and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include pancreas, thymus and tongue, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Tubular Adenocarcinoma

Diseases related to Tubular Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 255)
# Related Disease Score Top Affiliating Genes
1 gastric tubular adenocarcinoma 33.4 CDX2 CHGA MUC1 MUC2
2 thymus adenocarcinoma 30.4 CDX2 KRT20
3 hepatoid adenocarcinoma 29.9 AFP CDX2 EGFR MUC1
4 large cell neuroendocrine carcinoma 29.9 CHGA EGFR KRT20
5 small cell carcinoma 29.9 CHGA EGFR KRT20
6 adenocarcinoma 29.7 CDH1 EGFR ERBB2 MUC1
7 microglandular adenosis 29.6 EGFR ERBB2 PGR
8 microinvasive gastric cancer 29.6 CDH1 CDX2 MUC2
9 gastric cancer 28.4 CDH1 CDX2 EGFR ERBB2 MUC2
10 barrett esophagus 27.8 CDH1 CDX2 ERBB2 KRT20 MUC2
11 mucinous intrahepatic cholangiocarcinoma 10.8 CDX2 MUC2
12 adult teratoma 10.8 AFP CHGA
13 epithelioid malignant peripheral nerve sheath tumor 10.7 CHGA MUC1
14 malignant peritoneal mesothelioma 10.7 EGFR MUC1
15 sclerosing hepatic carcinoma 10.7 AFP CHGA
16 chordoid meningioma 10.7 CHGA MUC1
17 pancreatic intraductal papillary-mucinous neoplasm 10.7 MUC1 MUC2
18 tumor of exocrine pancreas 10.7 MUC1 MUC2
19 bronchiolo-alveolar adenocarcinoma 10.7 CDX2 EGFR
20 bile duct mucoepidermoid carcinoma 10.7 MUC1 MUC2
21 pancreatic acinar cell adenocarcinoma 10.7 AFP CHGA
22 chronic ethmoiditis 10.7 MUC1 MUC2
23 pulmonary blastoma 10.7 CHGA EGFR
24 chronic cholangitis 10.7 CDX2 MUC2
25 tn polyagglutination syndrome 10.7 MUC1 MUC2
26 liver sarcoma 10.6 AFP CHGA
27 olfactory groove meningioma 10.6 CHGA PGR
28 pancreatic serous cystadenoma 10.6 CHGA PGR
29 breast intraductal proliferative lesion 10.6 EGFR ERBB2
30 ovarian large-cell neuroendocrine carcinoma 10.6 CHGA KRT20
31 adenoma of the pancreas 10.6 CHGA KRT20
32 pancreatoblastoma 10.6 AFP CHGA
33 mucinous ovarian cystadenoma 10.6 CDX2 MUC1
34 small cell carcinoma of the bladder 10.6 CHGA KRT20
35 polyposis, skin pigmentation, alopecia, and fingernail changes 10.6 CDX2 MUC2
36 mixed hepatoblastoma 10.6 AFP PGR
37 endosalpingiosis 10.5 MUC1 PGR
38 anterior cranial fossa meningioma 10.5 CHGA PGR
39 mucinous tubular and spindle renal cell carcinoma 10.5 MUC1 MUC2
40 ethmoid sinusitis 10.5 MUC1 MUC2
41 appendix adenocarcinoma 10.5 CDX2 KRT20
42 malignant mixed mullerian tumor 10.5 MUC1 PGR
43 glandular cystitis 10.5 CDX2 KRT20
44 colloid carcinoma of the pancreas 10.5 MUC1 MUC2
45 superior mesenteric artery syndrome 10.5 CDX2 MUC2
46 nonseminomatous germ cell tumor 10.5 AFP ERBB2
47 sclerosing hemangioma 10.5 CHGA MUC1
48 bladder adenocarcinoma 10.4 CDX2 KRT20
49 jejunal adenocarcinoma 10.4 CDX2 KRT20
50 scirrhous adenocarcinoma 10.4 ERBB2 PGR

Graphical network of the top 20 diseases related to Tubular Adenocarcinoma:



Diseases related to Tubular Adenocarcinoma

Symptoms & Phenotypes for Tubular Adenocarcinoma

MGI Mouse Phenotypes related to Tubular Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.08 MUC2 PGR ESR1 CHGA EGFR CDH1
2 endocrine/exocrine gland MP:0005379 10.06 MUC2 PGR CHGA AFP EGFR CDH1
3 homeostasis/metabolism MP:0005376 10.02 MUC2 PGR ESR1 CHGA AFP EGFR
4 digestive/alimentary MP:0005381 9.93 MUC2 ESR1 EGFR CDH1 ERBB2 CDX2
5 embryo MP:0005380 9.91 ESR1 PGR EGFR CDH1 ERBB2 CDX2
6 mortality/aging MP:0010768 9.91 MUC2 PGR ESR1 CHGA AFP EGFR
7 neoplasm MP:0002006 9.76 MUC2 PGR AFP EGFR CDH1 ERBB2
8 limbs/digits/tail MP:0005371 9.72 PGR ESR1 EGFR ERBB2 CDX2
9 normal MP:0002873 9.43 ESR1 PGR CDX2 EGFR CDH1 ERBB2
10 reproductive system MP:0005389 9.23 PGR ESR1 CHGA AFP EGFR CDH1

Drugs & Therapeutics for Tubular Adenocarcinoma

Drugs for Tubular Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved 95058-81-4 60750
2 Immunosuppressive Agents
3 Anti-Infective Agents
4 Antimetabolites
5 Antiviral Agents
6 Antimetabolites, Antineoplastic
7 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Modulation of the Immune Response in Patients With Pancreatic Tubular Adenocarcinoma Unknown status NCT01021800 Phase 2
2 Influence of Gemcitabine Treatment on Immunological and Serological Profile in Patients With Pancreatic Cancer Unknown status NCT00947102
3 Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 Lesions Recruiting NCT02638935 Not Applicable

Search NIH Clinical Center for Tubular Adenocarcinoma

Genetic Tests for Tubular Adenocarcinoma

Anatomical Context for Tubular Adenocarcinoma

MalaCards organs/tissues related to Tubular Adenocarcinoma:

41
Pancreas, Thymus, Tongue, B Cells, Lymph Node, Bone

Publications for Tubular Adenocarcinoma

Articles related to Tubular Adenocarcinoma:

(show all 34)
# Title Authors Year
1
Endocytoscopy of Superficial Nonampullary Duodenal Epithelial Tumor: Two Cases of Tubular Adenocarcinoma and Adenoma. ( 29109501 )
2017
2
Effectiveness of Magnifying Narrow-Band Imaging Endoscopy for Differential Diagnosis between the High-Risk Mixed-Type and Low-Risk Simple-Type of Low-Grade, Well-Differentiated Gastric Tubular Adenocarcinoma. ( 27127502 )
2016
3
A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature. ( 26040775 )
2015
4
Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer. ( 25730011 )
2015
5
Triple composite tumor of stomach: a rare combination of alpha fetoprotein positive hepatoid adenocarcinoma, tubular adenocarcinoma and large cell neuroendocrine carcinoma. ( 24739843 )
2014
6
Serine protease inhibitor Kazal type 1 and epidermal growth factor receptor are expressed in pancreatic tubular adenocarcinoma, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. ( 23475261 )
2013
7
Synchronous occurrence of advanced neuroendocrine carcinoma and tubular adenocarcinoma of the rectum. ( 23626511 )
2013
8
Thymic papillo-tubular adenocarcinoma containing a cyst: report of a case. ( 22407350 )
2012
9
Diffusion-weighted imaging findings of mucinous carcinoma arising in the ano-rectal region: comparison of apparent diffusion coefficient with that of tubular adenocarcinoma. ( 22173559 )
2012
10
Synchronous occurrence of early neuroendocrine carcinoma and tubular adenocarcinoma in the stomach. ( 26182399 )
2012
11
Combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus. ( 20952273 )
2011
12
Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions. ( 21487870 )
2011
13
Synchronous malignant B-cell lymphoma and gastric tubular adenocarcinoma associated with paraneoplastic cutaneous vasculitis: hypereosinophilic syndrome with mixed cryoglobulinemia is an important sign of paraneoplastic syndrome. ( 21139921 )
2009
14
Cystic duct tubular adenocarcinoma. ( 19923822 )
2009
15
Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach. ( 18506939 )
2008
16
Tubular adenocarcinoma of the thymus: case report and review of the literature. ( 16959713 )
2006
17
Intraductal tubular adenocarcinoma of the pancreas diagnosed before surgery by transpapillary biopsy: case report and review. ( 15729258 )
2005
18
A comparative clinical study of gallbladder tubular adenocarcinoma according to the grade of differentiation. ( 15549451 )
2004
19
Neuroendocrine differentiation of periodic-acid Schiff and Alcian blue-negative signet-ring cell-like cells and tubular adenocarcinoma cells within a gastric cancer. ( 15513370 )
2004
20
What is your diagnosis? Tubular adenocarcinoma causing hematuria. ( 15049570 )
2004
21
Primary coexistent neuroendocrine carcinoma, hepatoid adenocarcinoma, and tubular adenocarcinoma of the stomach with focal trophoblastic differentiation in metastatic lymph nodes. ( 12858843 )
2003
22
Histogenesis of hepatoid adenocarcinoma of the stomach: molecular evidence of identical origin with coexistent tubular adenocarcinoma. ( 12845645 )
2003
23
A gastric carcinosarcoma with neuroendocrine cell differentiation and undifferentiated spindle-shaped sarcoma component possibly progressing from the conventional tubular adenocarcinoma; an immunohistochemical and ultrastructural study. ( 12536318 )
2003
24
A unique early gastric tubular adenocarcinoma arising from a pre-existent carcinoid tumor in a patient with a more than 20-year history of type A gastritis: an immunohistochemical and ultrastructural study. ( 12117270 )
2002
25
Cytologic features of tubular adenocarcinoma of the breast by aspiration biopsy. ( 11747222 )
2001
26
Histochemical determination of stereoselectivity of esterases in normal pancreas and pancreatic tubular adenocarcinoma of hamsters. ( 9554581 )
1998
27
Primary tubular adenocarcinoma arising in the duodenal limb of reconstructed gastroduodenostomy for signet-ring cell carcinoma of the stomach. ( 8574340 )
1995
28
Combined choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma in the oesophagus. ( 8548132 )
1995
29
Trisomy 1 in a canine mammary tubular adenocarcinoma, complex type. ( 8333114 )
1993
30
Leukemoid blood response and bone infarcts in a dog with renal tubular adenocarcinoma. ( 2276960 )
1990
31
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. ( 2101677 )
1990
32
Tubular adenocarcinoma of the apex of the tongue. ( 2642963 )
1989
33
Mammary tubular adenocarcinoma in a galago. ( 2811286 )
1989
34
Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. ( 3281095 )
1988

Variations for Tubular Adenocarcinoma

Expression for Tubular Adenocarcinoma

Search GEO for disease gene expression data for Tubular Adenocarcinoma.

Pathways for Tubular Adenocarcinoma

Pathways related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1 12.52 CDH1 EGFR ERBB2 ESR1
2
Show member pathways
12.43 CDH1 EGFR ERBB2 ESR1
3
Show member pathways
12.19 CDH1 EGFR ERBB2 MUC1
4 12 EGFR ERBB2 ESR1
5 11.84 CDH1 EGFR ESR1
6
Show member pathways
11.83 CDH1 CDX2 EGFR ERBB2 ESR1 MUC2
7
Show member pathways
11.51 EGFR ERBB2 ESR1
8 11.36 CDH1 EGFR ERBB2
9 11.29 CDH1 EGFR ERBB2
10
Show member pathways
11.29 EGFR ERBB2 ESR1 PGR
11 10.99 EGFR ERBB2
12 10.82 CDH1 EGFR ERBB2
13 10.71 CDH1 EGFR

GO Terms for Tubular Adenocarcinoma

Biological processes related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.43 EGFR ERBB2 ESR1
2 regulation of cell motility GO:2000145 9.37 EGFR ERBB2
3 regulation of ERK1 and ERK2 cascade GO:0070372 9.32 EGFR ERBB2
4 negative regulation of ERBB signaling pathway GO:1901185 9.16 EGFR ERBB2
5 phosphatidylinositol phosphorylation GO:0046854 9.13 EGFR ERBB2 ESR1
6 ovulation from ovarian follicle GO:0001542 8.62 AFP PGR

Molecular functions related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.65 CDH1 EGFR ERBB2 ESR1 PGR
2 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.16 EGFR ERBB2
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.13 EGFR ERBB2 ESR1
4 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR ESR1

Sources for Tubular Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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