MCID: TBL003
MIFTS: 35

Tubular Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Tubular Adenocarcinoma

MalaCards integrated aliases for Tubular Adenocarcinoma:

Name: Tubular Adenocarcinoma 12 15
Adenocarcinoma, Tubular 73
Adenocarcinoma Tubular 55
Tubular Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4929
MeSH 44 D000230
NCIt 50 C65192
SNOMED-CT 68 4631006
UMLS 73 C0205645

Summaries for Tubular Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.

MalaCards based summary : Tubular Adenocarcinoma, also known as adenocarcinoma, tubular, is related to gastric tubular adenocarcinoma and hepatoid adenocarcinoma. An important gene associated with Tubular Adenocarcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways are Gastric cancer and Signaling by ERBB4. The drugs Gemcitabine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, pancreas and thymus, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Related Diseases for Tubular Adenocarcinoma

Diseases related to Tubular Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 331)
# Related Disease Score Top Affiliating Genes
1 gastric tubular adenocarcinoma 33.3 CDX2 CHGA MUC1 MUC2 SYP
2 hepatoid adenocarcinoma 30.4 AFP CDX2 MUC1
3 thymus adenocarcinoma 30.0 CDX2 KRT20
4 microglandular adenosis 29.9 ERBB2 PGR
5 carcinoid syndrome 29.8 CHGA SYP
6 microinvasive gastric cancer 29.8 CDH1 CDX2 MUC2
7 carcinosarcoma 29.7 ERBB2 MUC1 PGR
8 breast secretory carcinoma 29.7 ERBB2 PGR
9 in situ carcinoma 29.6 CDH1 ERBB2 ESR1 PGR
10 small cell carcinoma 29.5 CHGA KRT20 SYP
11 large cell neuroendocrine carcinoma 29.5 CHGA KRT20 SYP
12 breast fibroadenoma 29.5 ERBB2 ESR1 PGR
13 ductal carcinoma in situ 29.4 CDH1 ERBB2 ESR1 MUC1 PGR
14 barrett esophagus 29.4 CDX2 ERBB2 KRT20 MUC2
15 lobular neoplasia 29.2 CDH1 ERBB2 ESR1 MUC1
16 gastric cancer 29.2 AFP CDH1 CDX2 ERBB2 KRT20 MUC2
17 adenocarcinoma 10.6
18 mucinous intrahepatic cholangiocarcinoma 10.3 CDX2 MUC2
19 adult teratoma 10.3 AFP CHGA
20 duodenum adenocarcinoma 10.3 CDX2 MUC2
21 epithelioid malignant peripheral nerve sheath tumor 10.3 CHGA MUC1
22 tumor of exocrine pancreas 10.3 MUC1 MUC2
23 pancreatic intraductal papillary-mucinous neoplasm 10.3 MUC1 MUC2
24 sclerosing hepatic carcinoma 10.3 AFP CHGA
25 bile duct mucoepidermoid carcinoma 10.3 MUC1 MUC2
26 chronic ethmoiditis 10.3 MUC1 MUC2
27 chronic cholangitis 10.3 CDX2 MUC2
28 pancreatic acinar cell adenocarcinoma 10.2 AFP CHGA
29 liver sarcoma 10.2 AFP CHGA
30 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 CDX2 MUC2
31 mucinous tubular and spindle renal cell carcinoma 10.2 MUC1 MUC2
32 breast mucoepidermoid carcinoma 10.2 MUC1 PGR
33 superior mesenteric artery syndrome 10.2 CDX2 MUC2
34 endosalpingiosis 10.2 MUC1 PGR
35 ethmoid sinusitis 10.2 MUC1 MUC2
36 mixed hepatoblastoma 10.2 AFP PGR
37 embryoma 10.2 AFP CDX2
38 ureter small cell carcinoma 10.2 CHGA SYP
39 colloid carcinoma of the pancreas 10.2 MUC1 MUC2
40 endodermal sinus tumor 10.2 AFP CHGA
41 esophageal neuroendocrine tumor 10.2 CHGA SYP
42 urinary bladder small cell neuroendocrine carcinoma 10.2 CHGA SYP
43 auditory system cancer 10.2 CHGA SYP
44 acinar cell cystadenocarcinoma 10.2 CHGA SYP
45 peritoneal serous adenocarcinoma 10.2 CHGA SYP
46 cellular ependymoma 10.2 CHGA SYP
47 gallbladder small cell carcinoma 10.2 CHGA SYP
48 primary hepatic neuroendocrine carcinoma 10.2 CHGA SYP
49 nonseminomatous germ cell tumor 10.2 AFP ERBB2
50 gastrointestinal neuroendocrine tumor 10.2 CHGA SYP

Graphical network of the top 20 diseases related to Tubular Adenocarcinoma:



Diseases related to Tubular Adenocarcinoma

Symptoms & Phenotypes for Tubular Adenocarcinoma

MGI Mouse Phenotypes related to Tubular Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 CDH1 CDX2 CHGA ERBB2 ESR1 MUC2
2 endocrine/exocrine gland MP:0005379 9.86 AFP CDH1 CDX2 CHGA ERBB2 ESR1
3 neoplasm MP:0002006 9.7 AFP CDH1 CDX2 ERBB2 ESR1 MUC2
4 normal MP:0002873 9.43 CDH1 CDX2 ERBB2 ESR1 PGR SYP
5 reproductive system MP:0005389 9.17 AFP CDH1 CDX2 CHGA ERBB2 ESR1

Drugs & Therapeutics for Tubular Adenocarcinoma

Drugs for Tubular Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved 95058-81-4 60750
2 Anti-Infective Agents
3 Immunosuppressive Agents
4 Antimetabolites, Antineoplastic
5 Immunologic Factors
6 Antimetabolites
7 Antiviral Agents
8 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Modulation of the Immune Response in Patients With Pancreatic Tubular Adenocarcinoma Unknown status NCT01021800 Phase 2
2 Influence of Gemcitabine Treatment on Immunological and Serological Profile in Patients With Pancreatic Cancer Unknown status NCT00947102
3 Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 Lesions Recruiting NCT02638935 Not Applicable

Search NIH Clinical Center for Tubular Adenocarcinoma

Genetic Tests for Tubular Adenocarcinoma

Anatomical Context for Tubular Adenocarcinoma

MalaCards organs/tissues related to Tubular Adenocarcinoma:

41
Kidney, Pancreas, Thymus, B Cells, Lung, Ovary, Appendix

Publications for Tubular Adenocarcinoma

Articles related to Tubular Adenocarcinoma:

(show all 37)
# Title Authors Year
1
MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma. ( 30531928 )
2018
2
Endocytoscopy of Superficial Nonampullary Duodenal Epithelial Tumor: Two Cases of Tubular Adenocarcinoma and Adenoma. ( 29109501 )
2017
3
Effectiveness of Magnifying Narrow-Band Imaging Endoscopy for Differential Diagnosis between the High-Risk Mixed-Type and Low-Risk Simple-Type of Low-Grade, Well-Differentiated Gastric Tubular Adenocarcinoma. ( 27127502 )
2016
4
A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature. ( 26040775 )
2015
5
Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer. ( 25730011 )
2015
6
Triple composite tumor of stomach: a rare combination of alpha fetoprotein positive hepatoid adenocarcinoma, tubular adenocarcinoma and large cell neuroendocrine carcinoma. ( 24739843 )
2014
7
Serine protease inhibitor Kazal type 1 and epidermal growth factor receptor are expressed in pancreatic tubular adenocarcinoma, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. ( 23475261 )
2013
8
Synchronous occurrence of advanced neuroendocrine carcinoma and tubular adenocarcinoma of the rectum. ( 23626511 )
2013
9
Thymic papillo-tubular adenocarcinoma containing a cyst: report of a case. ( 22407350 )
2012
10
Diffusion-weighted imaging findings of mucinous carcinoma arising in the ano-rectal region: comparison of apparent diffusion coefficient with that of tubular adenocarcinoma. ( 22173559 )
2012
11
Synchronous occurrence of early neuroendocrine carcinoma and tubular adenocarcinoma in the stomach. ( 26182399 )
2012
12
Combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus. ( 20952273 )
2011
13
Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions. ( 21487870 )
2011
14
Synchronous malignant B-cell lymphoma and gastric tubular adenocarcinoma associated with paraneoplastic cutaneous vasculitis: hypereosinophilic syndrome with mixed cryoglobulinemia is an important sign of paraneoplastic syndrome. ( 21139921 )
2009
15
Cystic duct tubular adenocarcinoma. ( 19923822 )
2009
16
Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach. ( 18506939 )
2008
17
Tubular adenocarcinoma of the thymus: case report and review of the literature. ( 16959713 )
2006
18
Intraductal tubular adenocarcinoma of the pancreas diagnosed before surgery by transpapillary biopsy: case report and review. ( 15729258 )
2005
19
A comparative clinical study of gallbladder tubular adenocarcinoma according to the grade of differentiation. ( 15549451 )
2004
20
Neuroendocrine differentiation of periodic-acid Schiff and Alcian blue-negative signet-ring cell-like cells and tubular adenocarcinoma cells within a gastric cancer. ( 15513370 )
2004
21
What is your diagnosis? Tubular adenocarcinoma causing hematuria. ( 15049570 )
2004
22
Primary coexistent neuroendocrine carcinoma, hepatoid adenocarcinoma, and tubular adenocarcinoma of the stomach with focal trophoblastic differentiation in metastatic lymph nodes. ( 12858843 )
2003
23
Histogenesis of hepatoid adenocarcinoma of the stomach: molecular evidence of identical origin with coexistent tubular adenocarcinoma. ( 12845645 )
2003
24
A gastric carcinosarcoma with neuroendocrine cell differentiation and undifferentiated spindle-shaped sarcoma component possibly progressing from the conventional tubular adenocarcinoma; an immunohistochemical and ultrastructural study. ( 12536318 )
2003
25
A unique early gastric tubular adenocarcinoma arising from a pre-existent carcinoid tumor in a patient with a more than 20-year history of type A gastritis: an immunohistochemical and ultrastructural study. ( 12117270 )
2002
26
Cytologic features of tubular adenocarcinoma of the breast by aspiration biopsy. ( 11747222 )
2001
27
Histochemical determination of stereoselectivity of esterases in normal pancreas and pancreatic tubular adenocarcinoma of hamsters. ( 9554581 )
1998
28
Primary tubular adenocarcinoma arising in the duodenal limb of reconstructed gastroduodenostomy for signet-ring cell carcinoma of the stomach. ( 8574340 )
1995
29
Combined choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma in the oesophagus. ( 8548132 )
1995
30
"Very well differentiated tubular adenocarcinoma" of the stomach: its endoscopic and histopathological characteristics. ( 8007422 )
1994
31
Trisomy 1 in a canine mammary tubular adenocarcinoma, complex type. ( 8333114 )
1993
32
Leukemoid blood response and bone infarcts in a dog with renal tubular adenocarcinoma. ( 2276960 )
1990
33
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. ( 2101677 )
1990
34
Tubular adenocarcinoma of the apex of the tongue. ( 2642963 )
1989
35
Mammary tubular adenocarcinoma in a galago. ( 2811286 )
1989
36
Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. ( 3281095 )
1988
37
Malignant Tumours of the Kidney: Report of a Case of Tubular Adenocarcinoma of the Kidney. ( 29014083 )
1944

Variations for Tubular Adenocarcinoma

Expression for Tubular Adenocarcinoma

Search GEO for disease gene expression data for Tubular Adenocarcinoma.

Pathways for Tubular Adenocarcinoma

Pathways related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 CDH1 CDX2 ERBB2 ESR1 MUC2 PGR
2
Show member pathways
11.17 ERBB2 ESR1 PGR
3 10.65 CDH1 ERBB2

GO Terms for Tubular Adenocarcinoma

Biological processes related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ovulation from ovarian follicle GO:0001542 8.62 AFP PGR

Molecular functions related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 CDH1 ERBB2 ESR1 PGR SYP
2 steroid binding GO:0005496 8.96 ESR1 PGR

Sources for Tubular Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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