MCID: TBL003
MIFTS: 40

Tubular Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Tubular Adenocarcinoma

MalaCards integrated aliases for Tubular Adenocarcinoma:

Name: Tubular Adenocarcinoma 12 15 17
Adenocarcinoma, Tubular 74
Adenocarcinoma Tubular 56
Tubular Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4929
MeSH 45 D000230
NCIt 51 C65192
SNOMED-CT 69 4631006
UMLS 74 C0205645

Summaries for Tubular Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.

MalaCards based summary : Tubular Adenocarcinoma, also known as adenocarcinoma, tubular, is related to gastric tubular adenocarcinoma and hepatoid adenocarcinoma. An important gene associated with Tubular Adenocarcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways are Cytoskeletal Signaling and Gastric cancer. The drugs Rabeprazole and Proton Pump Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include thymus, ovary and kidney, and related phenotypes are Decreased viability in esophageal squamous lineage and endocrine/exocrine gland

Related Diseases for Tubular Adenocarcinoma

Diseases related to Tubular Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 370)
# Related Disease Score Top Affiliating Genes
1 gastric tubular adenocarcinoma 33.1 CDX2 CHGA KRT7 MUC1 SYP
2 hepatoid adenocarcinoma 30.6 AFP CDX2 MUC1
3 microglandular adenosis 30.1 ERBB2 PGR
4 in situ carcinoma 30.0 CDH1 ERBB2 ESR1 PGR
5 microinvasive gastric cancer 30.0 CDH1 CDX2
6 carcinoid syndrome 29.9 CHGA SYP
7 breast fibroadenoma 29.6 ERBB2 ESR1 PGR
8 thymus adenocarcinoma 29.6 CDX2 KRT20 KRT7
9 breast secretory carcinoma 29.5 ERBB2 KRT7 PGR
10 ductal carcinoma in situ 29.4 CDH1 ERBB2 ESR1 MUC1 PGR
11 carcinosarcoma 29.4 ERBB2 KRT7 MUC1 PGR
12 lobular neoplasia 29.3 CDH1 ERBB2 ESR1 MUC1
13 gastric cancer 29.1 AFP CDH1 CDX2 ERBB2 KRT20
14 barrett esophagus 29.0 CDX2 ERBB2 KRT20 KRT7
15 small cell carcinoma 28.9 CHGA KRT20 KRT7 SYP
16 large cell neuroendocrine carcinoma 28.9 CHGA KRT20 KRT7 SYP
17 adenocarcinoma 10.6
18 adult teratoma 10.4 AFP CHGA
19 epithelioid malignant peripheral nerve sheath tumor 10.4 CHGA MUC1
20 sclerosing hepatic carcinoma 10.4 AFP CHGA
21 pancreatic acinar cell adenocarcinoma 10.4 AFP CHGA
22 liver sarcoma 10.4 AFP CHGA
23 breast mucoepidermoid carcinoma 10.4 MUC1 PGR
24 mixed hepatoblastoma 10.4 AFP PGR
25 embryoma 10.4 AFP CDX2
26 nonseminomatous germ cell tumor 10.3 AFP ERBB2
27 scirrhous adenocarcinoma 10.3 ERBB2 PGR
28 endodermal sinus tumor 10.3 AFP CHGA
29 breast apocrine carcinoma 10.3 ERBB2 PGR
30 intracystic papillary adenoma 10.3 ERBB2 PGR
31 breast metaplastic carcinoma 10.3 ERBB2 PGR
32 ureter small cell carcinoma 10.3 CHGA SYP
33 progesterone-receptor negative breast cancer 10.3 ERBB2 PGR
34 esophageal neuroendocrine tumor 10.3 CHGA SYP
35 urinary bladder small cell neuroendocrine carcinoma 10.3 CHGA SYP
36 auditory system cancer 10.3 CHGA SYP
37 acinar cell cystadenocarcinoma 10.3 CHGA SYP
38 biphasic synovial sarcoma 10.3 CDH1 MUC1
39 peritoneal serous adenocarcinoma 10.3 CHGA SYP
40 cellular ependymoma 10.3 CHGA SYP
41 primary hepatic neuroendocrine carcinoma 10.3 CHGA SYP
42 gastrointestinal neuroendocrine tumor 10.3 CHGA SYP
43 syringoma 10.3 ESR1 MUC1
44 pulmonary large cell neuroendocrine carcinoma 10.3 CHGA SYP
45 atypical follicular adenoma 10.3 CHGA SYP
46 cauda equina neoplasm 10.3 CHGA SYP
47 esophagus adenocarcinoma 10.3 CDX2 ERBB2
48 uterine body mixed cancer 10.3 ERBB2 PGR
49 sarcomatoid renal cell carcinoma 10.3 CDH1 MUC1
50 sinonasal undifferentiated carcinoma 10.3 MUC1 SYP

Graphical network of the top 20 diseases related to Tubular Adenocarcinoma:



Diseases related to Tubular Adenocarcinoma

Symptoms & Phenotypes for Tubular Adenocarcinoma

GenomeRNAi Phenotypes related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.17 AFP CDH1 CHGA ERBB2 ESR1 KRT7

MGI Mouse Phenotypes related to Tubular Adenocarcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 AFP CDH1 CDX2 CHGA ERBB2 ESR1
2 neoplasm MP:0002006 9.63 AFP CDH1 CDX2 ERBB2 ESR1 PGR
3 normal MP:0002873 9.43 CDH1 CDX2 ERBB2 ESR1 PGR SYP
4 reproductive system MP:0005389 9.17 AFP CDH1 CDX2 CHGA ERBB2 ESR1

Drugs & Therapeutics for Tubular Adenocarcinoma

Drugs for Tubular Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
2 Proton Pump Inhibitors Phase 4
3 Antacids Phase 4
4 Anti-Ulcer Agents Phase 4
5 Gastrointestinal Agents Phase 4
6
Gemcitabine Approved 95058-81-4 60750
7 Immunologic Factors
8 Anti-Infective Agents
9 Antimetabolites, Antineoplastic
10 Antimetabolites
11 Antiviral Agents
12 Immunosuppressive Agents
13 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Oral Rabeprazole on the Prevention of Ulcer Bleeding Following Endoscopic Mucosal Resection Completed NCT00844675 Phase 4 rabeprazole;placebo
2 Modulation of the Immune Response in Patients With Pancreatic Tubular Adenocarcinoma Unknown status NCT01021800 Phase 2
3 Influence of Gemcitabine Treatment on Immunological and Serological Profile in Patients With Pancreatic Cancer Unknown status NCT00947102
4 Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 Lesions Recruiting NCT02638935 Not Applicable

Search NIH Clinical Center for Tubular Adenocarcinoma

Genetic Tests for Tubular Adenocarcinoma

Anatomical Context for Tubular Adenocarcinoma

MalaCards organs/tissues related to Tubular Adenocarcinoma:

42
Thymus, Ovary, Kidney, Testis, Appendix, Pancreas, Colon

Publications for Tubular Adenocarcinoma

Articles related to Tubular Adenocarcinoma:

(show all 41)
# Title Authors Year
1
Successful ex-vivo probe-based confocal laser endomicroscopy of a superficial nonampullary duodenal epithelial tumor with dripping of food additives: a case of tubular adenocarcinoma. ( 30899892 )
2019
2
A Case of Synchronous Three Gastric Fundic Gland Polyps with Low-grade Dysplasia Treated with Endoscopic Mucosal Resection after Being Diagnosed to be Tubular Adenocarcinoma Based on a Biopsy Specimen. ( 30918177 )
2019
3
Oncolytic activity of canine distemper virus in canine mammary tubular adenocarcinoma cells. ( 30756476 )
2019
4
Endoscopic and clinicopathological features of intramucosal, histologically mixed-type, low-grade, well-differentiated gastric tubular adenocarcinoma with the potential for late-onset lymph node metastasis. ( 30587141 )
2018
5
MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma. ( 30531928 )
2018
6
Endocytoscopy of Superficial Nonampullary Duodenal Epithelial Tumor: Two Cases of Tubular Adenocarcinoma and Adenoma. ( 29109501 )
2017
7
Effectiveness of Magnifying Narrow-Band Imaging Endoscopy for Differential Diagnosis between the High-Risk Mixed-Type and Low-Risk Simple-Type of Low-Grade, Well-Differentiated Gastric Tubular Adenocarcinoma. ( 27127502 )
2016
8
Differential microRNA expression in signet-ring cell carcinoma compared with tubular adenocarcinoma of human gastric cancer. ( 25730011 )
2015
9
A Rare Case of Primary Tubular Adenocarcinoma of the Thymus, Enteric Immunophenotype: A Case Study and Review of the Literature. ( 26040775 )
2015
10
Triple composite tumor of stomach: a rare combination of alpha fetoprotein positive hepatoid adenocarcinoma, tubular adenocarcinoma and large cell neuroendocrine carcinoma. ( 24739843 )
2014
11
Synchronous occurrence of advanced neuroendocrine carcinoma and tubular adenocarcinoma of the rectum. ( 23626511 )
2013
12
Serine protease inhibitor Kazal type 1 and epidermal growth factor receptor are expressed in pancreatic tubular adenocarcinoma, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. ( 23475261 )
2013
13
Synchronous occurrence of early neuroendocrine carcinoma and tubular adenocarcinoma in the stomach. ( 26182399 )
2012
14
Diffusion-weighted imaging findings of mucinous carcinoma arising in the ano-rectal region: comparison of apparent diffusion coefficient with that of tubular adenocarcinoma. ( 22173559 )
2012
15
Thymic papillo-tubular adenocarcinoma containing a cyst: report of a case. ( 22407350 )
2012
16
Combined tubular adenocarcinoma and hepatoid adenocarcinoma arising in Barrett esophagus. ( 20952273 )
2011
17
Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions. ( 21487870 )
2011
18
Synchronous malignant B-cell lymphoma and gastric tubular adenocarcinoma associated with paraneoplastic cutaneous vasculitis: hypereosinophilic syndrome with mixed cryoglobulinemia is an important sign of paraneoplastic syndrome. ( 21139921 )
2009
19
Cystic duct tubular adenocarcinoma. ( 19923822 )
2009
20
Combined choriocarcinoma, neuroendocrine cell carcinoma and tubular adenocarcinoma in the stomach. ( 18506939 )
2008
21
Tubular adenocarcinoma of the thymus: case report and review of the literature. ( 16959713 )
2006
22
Intraductal tubular adenocarcinoma of the pancreas diagnosed before surgery by transpapillary biopsy: case report and review. ( 15729258 )
2005
23
What is your diagnosis? Tubular adenocarcinoma causing hematuria. ( 15049570 )
2004
24
Neuroendocrine differentiation of periodic-acid Schiff and Alcian blue-negative signet-ring cell-like cells and tubular adenocarcinoma cells within a gastric cancer. ( 15513370 )
2004
25
A comparative clinical study of gallbladder tubular adenocarcinoma according to the grade of differentiation. ( 15549451 )
2004
26
A gastric carcinosarcoma with neuroendocrine cell differentiation and undifferentiated spindle-shaped sarcoma component possibly progressing from the conventional tubular adenocarcinoma; an immunohistochemical and ultrastructural study. ( 12536318 )
2003
27
Primary coexistent neuroendocrine carcinoma, hepatoid adenocarcinoma, and tubular adenocarcinoma of the stomach with focal trophoblastic differentiation in metastatic lymph nodes. ( 12858843 )
2003
28
Histogenesis of hepatoid adenocarcinoma of the stomach: molecular evidence of identical origin with coexistent tubular adenocarcinoma. ( 12845645 )
2003
29
A unique early gastric tubular adenocarcinoma arising from a pre-existent carcinoid tumor in a patient with a more than 20-year history of type A gastritis: an immunohistochemical and ultrastructural study. ( 12117270 )
2002
30
Cytologic features of tubular adenocarcinoma of the breast by aspiration biopsy. ( 11747222 )
2001
31
Histochemical determination of stereoselectivity of esterases in normal pancreas and pancreatic tubular adenocarcinoma of hamsters. ( 9554581 )
1998
32
Combined choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma in the oesophagus. ( 8548132 )
1995
33
Primary tubular adenocarcinoma arising in the duodenal limb of reconstructed gastroduodenostomy for signet-ring cell carcinoma of the stomach. ( 8574340 )
1995
34
"Very well differentiated tubular adenocarcinoma" of the stomach: its endoscopic and histopathological characteristics. ( 8007422 )
1994
35
Trisomy 1 in a canine mammary tubular adenocarcinoma, complex type. ( 8333114 )
1993
36
A microglandular adenosis-like lesion simulating tubular adenocarcinoma of the breast. A case report with cytological and histological appearances. ( 2101677 )
1990
37
Leukemoid blood response and bone infarcts in a dog with renal tubular adenocarcinoma. ( 2276960 )
1990
38
Tubular adenocarcinoma of the apex of the tongue. ( 2642963 )
1989
39
Mammary tubular adenocarcinoma in a galago. ( 2811286 )
1989
40
Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue. ( 3281095 )
1988
41
Malignant Tumours of the Kidney: Report of a Case of Tubular Adenocarcinoma of the Kidney. ( 29014083 )
1944

Variations for Tubular Adenocarcinoma

Expression for Tubular Adenocarcinoma

Search GEO for disease gene expression data for Tubular Adenocarcinoma.

Pathways for Tubular Adenocarcinoma

Pathways related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 CDH1 KRT20 KRT7 MUC1
2
Show member pathways
11.69 CDH1 CDX2 ERBB2 ESR1 PGR
3
Show member pathways
11.37 ERBB2 ESR1 PGR
4 10.75 CDH1 ERBB2

GO Terms for Tubular Adenocarcinoma

Biological processes related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ovulation from ovarian follicle GO:0001542 8.62 AFP PGR

Molecular functions related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 CDH1 ERBB2 ESR1 PGR SYP
2 steroid binding GO:0005496 8.96 ESR1 PGR

Sources for Tubular Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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