MCID: TBL003
MIFTS: 40

Tubular Adenocarcinoma

Categories: Cancer diseases

Aliases & Classifications for Tubular Adenocarcinoma

MalaCards integrated aliases for Tubular Adenocarcinoma:

Name: Tubular Adenocarcinoma 12 15 17
Adenocarcinoma, Tubular 70
Adenocarcinoma Tubular 54
Tubular Carcinoma 12

Classifications:



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Disease Ontology 12 DOID:4929
MeSH 44 D000230
NCIt 50 C65192
SNOMED-CT 67 4631006
UMLS 70 C0205645

Summaries for Tubular Adenocarcinoma

Disease Ontology : 12 An adenocarcinoma that derives from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.

MalaCards based summary : Tubular Adenocarcinoma, also known as adenocarcinoma, tubular, is related to gastric tubular adenocarcinoma and hepatoid adenocarcinoma. An important gene associated with Tubular Adenocarcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Proteoglycans in cancer. The drug Gemcitabine has been mentioned in the context of this disorder. Affiliated tissues include breast, colon and pancreas, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Tubular Adenocarcinoma

Diseases related to Tubular Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 659)
# Related Disease Score Top Affiliating Genes
1 gastric tubular adenocarcinoma 32.5 MUC5AC MIR21
2 hepatoid adenocarcinoma 30.5 MUC1 EGFR CDX2 AFP
3 thymus adenocarcinoma 30.0 KRT20 CEACAM5 CDX2
4 carcinoid syndrome 29.9 SYP ENO2 CHGA
5 microinvasive gastric cancer 29.9 MUC5AC ERBB2 CEACAM5 CDX2 CDH1 AFP
6 comedo carcinoma 29.9 PGR ESR1 ERBB2
7 lobular neoplasia 29.9 PGR MUC1 ESR1 ERBB2 CTNNB1 CDH1
8 in situ carcinoma 29.9 PGR MUC1 ESR1 ERBB2 EGFR CTNNB1
9 gynecomastia 29.8 PGR ESR1 ERBB2
10 acinar cell carcinoma 29.7 KRT7 CTNNB1 CHGA AFP
11 microglandular adenosis 29.6 PGR ESR1 ERBB2 EGFR CDH1
12 adenosquamous carcinoma 29.5 SYP MUC1 KRT7 EGFR CEACAM5
13 adenocarcinoma 29.4 MUC1 KRT7 KRT20 ERBB2 EGFR CTNNB1
14 ductal carcinoma in situ 29.4 PGR MUC1 MME ESR1 ERBB2 EGFR
15 gastric adenocarcinoma 29.3 KRT20 ERBB2 CTNNB1 CEACAM5 CDX2 CDH1
16 pancreatic ductal adenocarcinoma 29.3 MUC1 MIR21 ERBB2 EGFR CTNNB1 CDH1
17 mucinous cystadenocarcinoma 29.3 MUC2 MUC1 KRT7 KRT20 CEACAM5
18 breast fibroadenoma 29.3 PGR MME ESR1 ERBB2
19 gallbladder cancer 29.3 ERBB2 EGFR CTNNB1 CEACAM5 CDX2 CDH1
20 lymphoepithelioma-like carcinoma 29.1 MUC1 KRT7 KRT20 ENO2 EGFR CDH1
21 breast malignant phyllodes tumor 29.1 PGR MME ESR1 ERBB2 EGFR
22 basaloid squamous cell carcinoma 29.0 SYP KRT7 KRT20 ENO2 EGFR CHGA
23 cystadenocarcinoma 29.0 PGR MUC5AC MUC2 MUC1 KRT7 ERBB2
24 cystic teratoma 28.9 SYP MUC5AC KRT7 KRT20 ENO2 CDX2
25 neuroendocrine carcinoma 28.9 SYP MUC1 KRT7 KRT20 ENO2 CHGA
26 small cell carcinoma 28.9 SYP MUC1 KRT7 KRT20 ERBB2 ENO2
27 mature teratoma 28.9 SYP KRT7 ERBB2 ENO2 CEACAM5 AFP
28 esophageal cancer 28.9 MUC1 MIR21 ERBB2 EGFR CTNNB1 CEACAM5
29 large cell neuroendocrine carcinoma 28.8 SYP KRT7 KRT20 ERBB2 ENO2 EGFR
30 barrett esophagus 28.7 MUC5AC MUC2 KRT7 KRT20 ERBB2 CTNNB1
31 adenoma 28.7 SYP MUC5AC MUC1 KRT7 KRT20 CTNNB1
32 breast ductal carcinoma 28.7 PGR MUC5AC MUC1 KRT7 ESR1 ERBB2
33 breast adenocarcinoma 28.5 SYP PGR KRT7 ESR1 ERBB2 ENO2
34 carcinosarcoma 28.4 PGR MUC1 MME KRT7 ERBB2 EGFR
35 benign teratoma 28.3 SYP MUC1 KRT7 KRT20 ENO2 CHGA
36 signet ring cell adenocarcinoma 28.2 MUC5AC MUC2 MUC1 KRT7 KRT20 ERBB2
37 cystadenoma 27.9 SYP PGR MUC5AC MUC1 MME KRT7
38 gastric cancer 27.4 PGR MUC5AC MUC2 MUC1 MIR21 KRT20
39 malignant peritoneal mesothelioma 10.4 MUC1 EGFR
40 colloid carcinoma of the pancreas 10.4 MUC5AC MUC1
41 pancreatic signet ring cell adenocarcinoma 10.4 MUC5AC MUC1
42 chronic ethmoiditis 10.4 MUC5AC MUC1
43 esophagus verrucous carcinoma 10.4 EGFR CDH1
44 scrotum paget's disease 10.4 MUC1 KRT7
45 anal canal paget's disease 10.4 KRT7 CDX2
46 gastric signet ring cell adenocarcinoma 10.4 KRT7 CDX2
47 nonseminomatous germ cell tumor 10.3 ERBB2 AFP
48 liver lipoma 10.3 CEACAM5 AFP
49 adenosquamous colon carcinoma 10.3 KRT7 CDX2
50 sebaceous breast carcinoma 10.3 ERBB2 CEACAM5

Graphical network of the top 20 diseases related to Tubular Adenocarcinoma:



Diseases related to Tubular Adenocarcinoma

Symptoms & Phenotypes for Tubular Adenocarcinoma

MGI Mouse Phenotypes related to Tubular Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10 AFP CDH1 CDX2 CHGA CTNNB1 EGFR
2 homeostasis/metabolism MP:0005376 10 AFP CDH1 CDX2 CHGA CTNNB1 EGFR
3 digestive/alimentary MP:0005381 9.97 CDH1 CDX2 CTNNB1 EGFR ERBB2 ESR1
4 neoplasm MP:0002006 9.61 AFP CDH1 CDX2 CTNNB1 EGFR ERBB2
5 no phenotypic analysis MP:0003012 9.17 CDH1 CHGA CTNNB1 EGFR ESR1 PGR

Drugs & Therapeutics for Tubular Adenocarcinoma

Drugs for Tubular Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved 95058-81-4 60750

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Modulation of the Immune Response in Patients With Pancreatic Tubular Adenocarcinoma Unknown status NCT01021800 Phase 2
2 Observational Study - Influence of Gemcitabine Treatment on Immunological and Serological Profile in Patients With Pancreatic Tubular Carcinoma Unknown status NCT00947102

Search NIH Clinical Center for Tubular Adenocarcinoma

Genetic Tests for Tubular Adenocarcinoma

Anatomical Context for Tubular Adenocarcinoma

MalaCards organs/tissues related to Tubular Adenocarcinoma:

40
Breast, Colon, Pancreas, Lymph Node, Liver, Small Intestine, Kidney

Publications for Tubular Adenocarcinoma

Articles related to Tubular Adenocarcinoma:

(show top 50) (show all 1305)
# Title Authors PMID Year
1
Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach. 61 54
19680592 2010
2
[A case of metastatic breast cancer with liver metastasis effectively treated with capecitabine and vinorelbine]. 61 54
19223759 2009
3
Tubular carcinoma and grade 1 (well-differentiated) invasive ductal carcinoma: comparison of flat epithelial atypia and other intra-epithelial lesions. 54 61
18801081 2008
4
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast. 61 54
18254778 2008
5
Fine needle aspiration cytologic findings of micropapillary carcinoma in the lung: a case report. 61 54
17718135 2007
6
The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study. 61 54
17143261 2007
7
[Expression of Smo protein and the downstream transcription factor Gli1 protein in Sonic hedgehog signal transduction pathway in gastric carcinoma]. 54 61
17259107 2006
8
HER-2 amplification in tubular carcinoma of the breast. 54 61
16753605 2006
9
Study of Sonic hedgehog signaling pathway related molecules in gastric carcinoma. 54 61
16810741 2006
10
p63 and CD10: reliable markers in discriminating benign sclerosing lesions from tubular carcinoma of the breast? 61 54
16540734 2006
11
Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct--an immunohistochemical study of 110 cases of hepatolithiasis. 61 54
16360234 2006
12
Intrahepatic cholangiocarcinoma detected by elevated levels of alpha-fetoprotein-L3 after hepatectomy for hepatocellular carcinoma in a patient with Budd-Chiari syndrome. 61 54
16119710 2005
13
Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance. 61 54
15378790 2004
14
[P63 protein in the diagnosis of breast tubular carcinoma]. 61 54
15567947 2004
15
Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma. 61 54
11777208 2001
16
Collecting duct carcinoma of the kidney associated with the sickle cell trait. 61 54
11501235 2001
17
Expression of neural cell adhesion molecule in pancreatic cancer. 61 54
11249065 2001
18
A case of synchronous double primary lung cancer with neuroendocrine features. 61 54
10340047 1999
19
A case of small cell carcinoma of the stomach. 61 54
9058136 1997
20
Alpha-fetoprotein, carcinoembryonic antigen, and carbohydrate antigen 19-9-producing gallbladder cancer. 61 54
8887046 1996
21
Factors influencing growth rate of recurrent stomach cancers as determined by analysis of serum carcinoembryonic antigen. 54 61
7889481 1995
22
Overexpression of c-erbB-2 protein in gastric cancer. Its correlation with long-term survival of patients. 61 54
7902202 1993
23
Immunohistochemical and biochemical measurement of estrogen and progesterone receptors in primary breast cancer. Correlation of histopathology and prognostic factors. 54 61
8328824 1993
24
[Colon adenocarcinoma with neuroendocrine and squamous cell differentiation. A case report]. 54 61
1307207 1992
25
[The relationship between carcinoembryonic antigen (CEA) expression and histogenesis of gastric cancer (application of immunohistochemical and mucin histochemical techniques)]. 61 54
1327687 1992
26
Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines. 61
33644423 2021
27
Neuroendocrine carcinoma and mixed neuroendocrine‒non-neuroendocrine neoplasm of the stomach: a clinicopathological and exome sequencing study. 61
33359239 2021
28
Breast tubular carcinoma at parasternal and retro-nipple area: Two case reports. 61
33725968 2021
29
The successful use of disparate pedicle types for bilateral therapeutic mammaplasties during breast conservation surgery. 61
33732428 2021
30
A case of Epstein-Barr virus-associated lymphoepithelioma-like carcinoma of the colon. 61
33792098 2021
31
Prognostic Impact of Radiation Therapy in Tubular Carcinoma of the Breast. 61
33753158 2021
32
A case of early rectal carcinoma with submucosal tumor-like morphology. 61
33751405 2021
33
[A Case of Gastric Cancer Which Caused Severe Anemia(Hemoglobin 1.8 g/dL)]. 61
33790158 2021
34
Breast cancer detection by dedicated breast positron emission tomography according to the World Health Organization classification of breast tumors. 61
33685728 2021
35
68Ga PSMA Uptake at Roux-en-Y Eso-jejunostomy Junction Mimicking the Recurrence of Gastric Carcinoma in PET/CT. 61
33586413 2021
36
Evaluation of immunohistopathological profile of tubular and solid canine mammary carcinomas. 61
33609969 2021
37
Mixed histology poses a greater risk for noncurative endoscopic resection in early gastric cancers regardless of the predominant histologic types. 61
32804856 2021
38
Constitutional mismatch repair deficiency in childhood colorectal cancer harboring a de novo variant in the MSH6 gene: a case report. 61
33568103 2021
39
NTRK fusion-positive colorectal cancer in Japanese population. 61
33631044 2021
40
An Autopsy Case of Anaplastic Carcinoma of the Pancreas in a 39-Year-Old Woman that Developed from Hereditary Pancreatitis. 61
33587725 2021
41
Clinicopathological features and lymph node metastasis risk in early gastric cancer with WHO criteria in China: 304 cases analysis. 61
33157382 2021
42
[A Case of Duodenal Adenocarcinoma in the Third Portion Treated with Partial Duodenectomy]. 61
33597385 2021
43
Two cases of gastric adenocarcinoma with enteroblastic differentiation resected by endoscopic submucosal dissection. 61
33629257 2021
44
Gastric poorly cohesive carcinoma: differentiation from tubular adenocarcinoma using nomograms based on CT findings in the 40 s late arterial phase. 61
33569616 2021
45
Long-term survival after surgical resection of metachronous lung, brain and thyroid gland metastases from rectal cancer: A case report. 61
33497998 2021
46
BMI-adjusted prognosis of signet ring cell carcinoma in patients undergoing radical gastrectomy for gastric adenocarcinoma. 61
32467008 2021
47
A Gastric Intramucosal Mixed Adenocarcinoma-Neuroendocrine Tumor. 61
33790721 2021
48
Relationship between HER2 expression and tumor interstitial angiogenesis in primary gastric cancer and its effect on prognosis. 61
33253925 2021
49
[A Case of Advanced Gastric Cancer with Peritoneal Dissemination after Gastrectomy Successfully Treated with Paclitaxel plus Ramucirumab]. 61
33468738 2021
50
Intrahepatic cholangiocarcinoma with a tumor thrombus extending from the inferior vena cava to the right atrium: a case report. 61
33409719 2021

Variations for Tubular Adenocarcinoma

Expression for Tubular Adenocarcinoma

Search GEO for disease gene expression data for Tubular Adenocarcinoma.

Pathways for Tubular Adenocarcinoma

GO Terms for Tubular Adenocarcinoma

Cellular components related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 SPINK1 MUC5AC MUC2 MUC1 MIR21 ENO2
2 perinuclear region of cytoplasm GO:0048471 9.73 SYP ERBB2 EGFR CTNNB1 CHGA CDH1
3 basolateral plasma membrane GO:0016323 9.67 ERBB2 EGFR CTNNB1 CEACAM5
4 flotillin complex GO:0016600 9.32 CTNNB1 CDH1
5 extracellular exosome GO:0070062 9.32 SPINK1 MUC5AC MUC1 MME MIR21 KRT7
6 mucus layer GO:0070701 8.96 MUC5AC MUC2

Biological processes related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to growth factor stimulus GO:0071363 9.58 ERBB2 EGFR CTNNB1
2 positive regulation of protein kinase B signaling GO:0051897 9.56 MIR21 ESR1 ERBB2 EGFR
3 O-glycan processing GO:0016266 9.5 MUC5AC MUC2 MUC1
4 intracellular steroid hormone receptor signaling pathway GO:0030518 9.46 PGR ESR1
5 endothelial tube morphogenesis GO:0061154 9.43 MIR21 CTNNB1
6 entry of bacterium into host cell GO:0035635 9.37 CTNNB1 CDH1
7 negative regulation of ERBB signaling pathway GO:1901185 9.16 ERBB2 EGFR
8 ovulation from ovarian follicle GO:0001542 8.96 PGR AFP
9 cellular response to indole-3-methanol GO:0071681 8.62 CTNNB1 CDH1

Molecular functions related to Tubular Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.13 PGR ESR1 EGFR
2 nitric-oxide synthase regulator activity GO:0030235 8.62 ESR1 EGFR

Sources for Tubular Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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