Aliases & Classifications for Tubulin, Beta

MalaCards integrated aliases for Tubulin, Beta:

Name: Tubulin, Beta 57 29

External Ids:

OMIM® 57 301850

Summaries for Tubulin, Beta

MalaCards based summary : Tubulin, Beta is related to cortical dysplasia, complex, with other brain malformations 1 and cortical dysplasia, complex, with other brain malformations 7. An important gene associated with Tubulin, Beta is TUBB (Tubulin Beta Class I), and among its related pathways/superpathways are Metabolism of proteins and Pathways of neurodegeneration - multiple diseases. Affiliated tissues include brain, lung and liver, and related phenotype is Increased number of mitotic cells.

More information from OMIM: 301850

Related Diseases for Tubulin, Beta

Diseases related to Tubulin, Beta via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 cortical dysplasia, complex, with other brain malformations 1 31.5 TUBB3 TUBB2B
2 cortical dysplasia, complex, with other brain malformations 7 11.1
3 macrothrombocytopenia, autosomal dominant, tubb1-related 11.1
4 cortical dysplasia, complex, with other brain malformations 5 11.1
5 cortical dysplasia, complex, with other brain malformations 6 11.1
6 torsion dystonia 4 11.1
7 gastric cancer 10.0
8 tubulinopathy-associated dysgyria 9.9 TUBB3 TUBB2B
9 neuroblastoma 1 9.9
10 mesothelioma, malignant 9.8
11 wilms tumor 1 9.8
12 ataxia and polyneuropathy, adult-onset 9.8
13 aging 9.8
14 alacrima, achalasia, and mental retardation syndrome 9.8
15 hypomyelinating leukodystrophy 9.8
16 mild cognitive impairment 9.8
17 rapidly involuting congenital hemangioma 9.8
18 leukodystrophy 9.8
19 squamous cell carcinoma 9.8
20 basal cell carcinoma 9.8
21 benign mesothelioma 9.8
22 glioblastoma 9.8
23 carcinosarcoma 9.8
24 pleomorphic adenoma 9.8
25 infertility 9.8
26 ovarian carcinosarcoma 9.8
27 adenoma 9.8
28 neuroblastoma 9.8
29 spasticity 9.8
30 tubulinopathy 9.8 TUBB3 TUBB2B TUBB
31 congenital ptosis 9.7 TUBB6 TUBB2B
32 lissencephaly 9.7 TUBB3 TUBB2B TUBB
33 duane retraction syndrome 9.7 TUBB6 TUBB2B
34 breast cancer 9.7
35 colorectal cancer 9.7
36 dengue hemorrhagic fever 9.7
37 spastic ataxia 9.7 TUBB6 TUBB2A
38 tukel syndrome 8.4 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B TUBB2A

Graphical network of the top 20 diseases related to Tubulin, Beta:



Diseases related to Tubulin, Beta

Symptoms & Phenotypes for Tubulin, Beta

Clinical features from OMIM®:

301850 (Updated 05-Apr-2021)

GenomeRNAi Phenotypes related to Tubulin, Beta according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased number of mitotic cells GR00098-A-3 8.8 TUBB TUBB2B TUBB4B

Drugs & Therapeutics for Tubulin, Beta

Search Clinical Trials , NIH Clinical Center for Tubulin, Beta

Genetic Tests for Tubulin, Beta

Genetic tests related to Tubulin, Beta:

# Genetic test Affiliating Genes
1 Tubulin, Beta 29

Anatomical Context for Tubulin, Beta

MalaCards organs/tissues related to Tubulin, Beta:

40
Brain, Lung, Liver, Cortex, Skin, Spinal Cord, Kidney

Publications for Tubulin, Beta

Articles related to Tubulin, Beta:

(show top 50) (show all 346)
# Title Authors PMID Year
1
Insights into the similarities and differences of whiteleg shrimp pre-soaked with sodium tripolyphosphate and sodium trimetaphosphate during frozen storage. 61
33516993 2021
2
An immunostaining panel of C-reactive protein, N-cadherin, and S100 calcium binding protein P is useful for intrahepatic cholangiocarcinoma subtyping. 61
33321161 2021
3
Transcriptome analyses and weighted gene coexpression network analysis reveal key pathways and genes involved in the rapid cold resistance of the Chinese white wax scale insect. 61
33687102 2021
4
Associations between TUBB-WWOX SNPs, their haplotypes, gene-gene, and gene-environment interactions and dyslipidemia. 61
33612478 2021
5
Enhanced neural differentiation of neural stem cells by sustained release of Shh from TG2 gene-modified EMSC co-culture in vitro. 61
33245424 2021
6
Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects. 61
33009822 2021
7
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress. 61
33459145 2021
8
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes. 61
33404293 2021
9
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy. 61
33455530 2021
10
Coated nanodiamonds interact with tubulin beta-III negative cells of adult brain tissue. 61
33272020 2020
11
PLK1 (polo like kinase 1)-dependent autophagy facilitates gefitinib-induced hepatotoxicity by degrading COX6A1 (cytochrome c oxidase subunit 6A1). 61
33315519 2020
12
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons. 61
33111641 2020
13
Identification and rescue of a novel TUBB8 mutation that causes the first mitotic division defects and infertility. 61
32949002 2020
14
Circular RNA circ_C16orf62 Suppresses Cell Growth in Gastric Cancer by miR-421/Tubulin beta-2A Chain (TUBB2A) Axis. 61
33006960 2020
15
Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs. 61
33034545 2020
16
Distinctive roles of syntaxin binding protein 4 and its action target, TP63, in lung squamous cell carcinoma: a theranostic study for the precision medicine. 61
32993587 2020
17
Identification of novel TUBB1 variants in patients with macrothrombocytopenia. 61
32892537 2020
18
CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis. 61
31818185 2020
19
Characterization of Seed Proteome Profile of Wild and Cultivated Chickpeas of India. 61
32914710 2020
20
Improving glucose metabolism in the auditory cortex delays the aging of auditory function of guinea pig. 61
32592712 2020
21
Neural differentiation of canine mesenchymal stem cells/multipotent mesenchymal stromal cells. 61
32778115 2020
22
Antibodies Against ARHGDIB and ARHGDIB Gene Expression Associate With Kidney Allograft Outcome. 61
31651716 2020
23
Long-term defects of nasal epithelium barrier functions in patients with nasopharyngeal carcinoma post chemo-radiotherapy. 61
32353641 2020
24
Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden and PD-L1 expression in cancer patients. 61
31479512 2020
25
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease. 61
31462148 2020
26
An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGFA, NOS1, and CTNNB1. 61
32579471 2020
27
Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport. 61
32397873 2020
28
Morphological differences between regenerating salivary glands after salivary gland duct ligation and embryonic salivary glands. 61
32061835 2020
29
Selection and validation of reliable reference genes for Tolypocladium guangdongense gene expression analysis under differentially developmental stages and temperature stresses. 61
31978511 2020
30
MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4. 61
31242129 2020
31
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. 61
31177901 2020
32
Axonal precursor miRNAs hitchhike on endosomes and locally regulate the development of neural circuits. 61
32073171 2020
33
ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression. 61
31187490 2020
34
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells. 61
30990357 2020
35
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). 61
30983487 2020
36
Novel Discoveries Targeting Pathogenic Gut Microbes and New Therapies in Pancreatic Cancer: Does Pathogenic E. coli Infection Cause Pancreatic Cancer Progression Modulated by TUBB/Rho/ROCK Signaling Pathway? A Bioinformatic Analysis. 61
32461969 2020
37
Proteomic profiling of peripheral blood mononuclear cells isolated from patients with tuberculosis and diabetes copathogenesis - A pilot study. 61
33156824 2020
38
FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas. 61
31473790 2020
39
Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma. 61
33193654 2020
40
Selection of the Reference Gene for Expression Normalization in Papaver somniferum L. under Abiotic Stress and Hormone Treatment. 61
31979407 2020
41
Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats. 61
32742258 2020
42
Maternal whole blood mRNA signatures identify women at risk of early preeclampsia: a longitudinal study. 61
31900005 2020
43
Proteome of cat semen obtained after urethral catheterization. 61
31518731 2020
44
Crosstalk between Mitochondria and Cytoskeleton in Cardiac Cells. 61
31963121 2020
45
Selection of Suitable Reference Genes for qPCR Gene Expression Analysis of HepG2 and L02 in Four Different Liver Cell Injured Models. 61
32733961 2020
46
Early expression of Tubulin Beta-III in avian cranial neural crest cells. 61
31369820 2019
47
Trypanosoma vivax infection in sheep: Different patterns of virulence and pathogenicity associated with differentially expressed proteomes. 61
32904712 2019
48
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. 61
30957628 2019
49
Targeted genomic integration of EGFP under tubulin beta 3 class III promoter and mEos2 under tryptophan hydroxylase 2 promoter does not produce sufficient levels of reporter gene expression. 61
31106442 2019
50
Chronic mild stress leads to aberrant glucose energy metabolism in depressed Macaca fascicularis models. 61
31108306 2019

Variations for Tubulin, Beta

Expression for Tubulin, Beta

Search GEO for disease gene expression data for Tubulin, Beta.

Pathways for Tubulin, Beta

Pathways related to Tubulin, Beta according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B TUBB2A
2
Show member pathways
13.36 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
3
Show member pathways
13.35 TUBB6 TUBB3 TUBB2B TUBB2A TUBB1
4
Show member pathways
13.04 TUBB6 TUBB3 TUBB2B TUBB2A TUBB1
5
Show member pathways
12.85 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
6
Show member pathways
12.83 TUBB6 TUBB3 TUBB2B TUBB2A TUBB1
7
Show member pathways
12.76 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
8
Show member pathways
12.74 TUBB6 TUBB3 TUBB2B TUBB2A TUBB1
9
Show member pathways
12.44 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B TUBB2A
10
Show member pathways
12.31 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
11
Show member pathways
12.29 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
12
Show member pathways
12.22 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
13
Show member pathways
12.22 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
14 12.2 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
15
Show member pathways
12.13 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B TUBB2A
16 12.04 TUBB6 TUBB3 TUBB2B TUBB2A TUBB1
17 11.92 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
18
Show member pathways
11.64 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
19 11.25 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B

GO Terms for Tubulin, Beta

Cellular components related to Tubulin, Beta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.91 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
2 extracellular exosome GO:0070062 9.76 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2A
3 cytoskeleton GO:0005856 9.61 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
4 azurophil granule lumen GO:0035578 9.32 TUBB4B TUBB
5 microtubule GO:0005874 9.28 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B

Biological processes related to Tubulin, Beta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based process GO:0007017 9.81 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
2 cytoskeleton organization GO:0007010 9.73 TUBB8 TUBB6 TUBB4A TUBB3 TUBB2B TUBB
3 mitotic cell cycle GO:0000278 9.61 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
4 G2/M transition of mitotic cell cycle GO:0000086 9.58 TUBB4B TUBB4A TUBB
5 ciliary basal body-plasma membrane docking GO:0097711 9.54 TUBB4B TUBB4A TUBB
6 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.5 TUBB4B TUBB4A TUBB
7 spindle assembly GO:0051225 9.46 TUBB1 TUBB
8 natural killer cell mediated cytotoxicity GO:0042267 9.43 TUBB4B TUBB
9 microtubule cytoskeleton organization GO:0000226 9.28 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B

Molecular functions related to Tubulin, Beta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.91 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
2 GTP binding GO:0005525 9.81 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
3 structural constituent of cytoskeleton GO:0005200 9.61 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
4 MHC class I protein binding GO:0042288 9.32 TUBB4B TUBB
5 GTPase activity GO:0003924 9.28 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B

Sources for Tubulin, Beta

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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