Aliases & Classifications for Tubulin, Beta

MalaCards integrated aliases for Tubulin, Beta:

Name: Tubulin, Beta 58 30

External Ids:

OMIM 58 301850

Summaries for Tubulin, Beta

MalaCards based summary : Tubulin, Beta is related to colorectal cancer and neuroblastoma. An important gene associated with Tubulin, Beta is TUBB (Tubulin Beta Class I), and among its related pathways/superpathways are Metabolism of proteins and Development Slit-Robo signaling. Affiliated tissues include brain and fetal brain, and related phenotype is Increased number of mitotic cells.

Description from OMIM: 301850

Related Diseases for Tubulin, Beta

Graphical network of the top 20 diseases related to Tubulin, Beta:



Diseases related to Tubulin, Beta

Symptoms & Phenotypes for Tubulin, Beta

Clinical features from OMIM:

301850

GenomeRNAi Phenotypes related to Tubulin, Beta according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased number of mitotic cells GR00098-A-3 8.8 TUBB TUBB2B TUBB4B

Drugs & Therapeutics for Tubulin, Beta

Search Clinical Trials , NIH Clinical Center for Tubulin, Beta

Genetic Tests for Tubulin, Beta

Genetic tests related to Tubulin, Beta:

# Genetic test Affiliating Genes
1 Tubulin, Beta 30

Anatomical Context for Tubulin, Beta

MalaCards organs/tissues related to Tubulin, Beta:

42
Brain, Fetal Brain

Publications for Tubulin, Beta

Articles related to Tubulin, Beta:

(show all 11)
# Title Authors Year
1
Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages. ( 28648944 )
2017
2
A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization. ( 27594048 )
2017
3
Identification alpha-2-HS-glycoprotein precursor and tubulin beta chain as serology diagnosis biomarker of colorectal cancer. ( 24618180 )
2014
4
Tubulin beta chain, filamin A alpha isoform 1, and cytochrome b-c1 complex subunit 1 as serological diagnostic biomarkers of esophageal squamous cell carcinoma: a proteomics study. ( 23496306 )
2013
5
Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. ( 22209775 )
2012
6
1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination. ( 20067570 )
2010
7
Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration? ( 19545277 )
2009
8
Fenretinide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells is associated with the differential expression of Hsp70, 14-3-3, pax-6, tubulin beta-III, NSE, and bag-1 proteins. ( 17110918 )
2006
9
Expression of tubulin beta II in neural stem/progenitor cells and radial fibers during human fetal brain development. ( 12695551 )
2003
10
The solution conformation of tubulin-beta(422-434)-NH2 and its Nac-DATADEQG-NH2 fragment based on NMR. ( 1863694 )
1991
11
Immunofluorescence distribution of alpha tubulin, beta tubulin and microtubule-associated protein 2 during in vitro maturation of cerebellar granule cell neurones. ( 6382049 )
1984

Variations for Tubulin, Beta

Expression for Tubulin, Beta

Search GEO for disease gene expression data for Tubulin, Beta.

Pathways for Tubulin, Beta

Pathways related to Tubulin, Beta according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B
2
Show member pathways
12.47 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
3
Show member pathways
12.39 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B
4
Show member pathways
12.29 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
5
Show member pathways
12.06 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B
6
Show member pathways
12.05 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
7 12.03 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
8 11.99 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
9
Show member pathways
11.77 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
10 11.76 TUBB1 TUBB2A TUBB3
11
Show member pathways
11.5 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
12 11.07 TUBB1 TUBB2A TUBB3

GO Terms for Tubulin, Beta

Cellular components related to Tubulin, Beta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.91 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
2 extracellular exosome GO:0070062 9.76 TUBB TUBB1 TUBB2A TUBB3 TUBB4A TUBB4B
3 cytoskeleton GO:0005856 9.61 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
4 azurophil granule lumen GO:0035578 9.37 TUBB TUBB4B
5 extracellular vesicle GO:1903561 9.32 TUBB2A TUBB4B
6 microtubule GO:0005874 9.28 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A

Biological processes related to Tubulin, Beta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule cytoskeleton organization GO:0000226 9.81 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
2 cytoskeleton organization GO:0007010 9.65 TUBB TUBB3 TUBB4A TUBB6 TUBB8
3 microtubule-based process GO:0007017 9.61 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
4 G2/M transition of mitotic cell cycle GO:0000086 9.58 TUBB TUBB4A TUBB4B
5 ciliary basal body-plasma membrane docking GO:0097711 9.54 TUBB TUBB4A TUBB4B
6 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.5 TUBB TUBB4A TUBB4B
7 spindle assembly GO:0051225 9.46 TUBB TUBB1
8 natural killer cell mediated cytotoxicity GO:0042267 9.43 TUBB TUBB4B
9 mitotic cell cycle GO:0000278 9.28 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A

Molecular functions related to Tubulin, Beta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.81 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
2 GTPase activity GO:0003924 9.61 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
3 nucleotide binding GO:0000166 9.5 TUBB TUBB4A TUBB4B
4 structural constituent of cytoskeleton GO:0005200 9.28 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A
5 MHC class I protein binding GO:0042288 9.26 TUBB TUBB4B

Sources for Tubulin, Beta

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
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38 KEGG
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41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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