Aliases & Classifications for Tubulin, Beta

MalaCards integrated aliases for Tubulin, Beta:

Name: Tubulin, Beta 56 29

External Ids:

OMIM 56 301850

Summaries for Tubulin, Beta

MalaCards based summary : Tubulin, Beta is related to cortical dysplasia, complex, with other brain malformations 1 and cortical dysplasia, complex, with other brain malformations 7. An important gene associated with Tubulin, Beta is TUBB (Tubulin Beta Class I), and among its related pathways/superpathways are Metabolism of proteins and Chaperonin-mediated protein folding. Affiliated tissues include brain, liver and lung, and related phenotype is Increased number of mitotic cells.

More information from OMIM: 301850

Related Diseases for Tubulin, Beta

Graphical network of the top 20 diseases related to Tubulin, Beta:



Diseases related to Tubulin, Beta

Symptoms & Phenotypes for Tubulin, Beta

Clinical features from OMIM:

301850

GenomeRNAi Phenotypes related to Tubulin, Beta according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased number of mitotic cells GR00098-A-3 8.8 TUBB TUBB2B TUBB4B

Drugs & Therapeutics for Tubulin, Beta

Search Clinical Trials , NIH Clinical Center for Tubulin, Beta

Genetic Tests for Tubulin, Beta

Genetic tests related to Tubulin, Beta:

# Genetic test Affiliating Genes
1 Tubulin, Beta 29

Anatomical Context for Tubulin, Beta

MalaCards organs/tissues related to Tubulin, Beta:

40
Brain, Liver, Lung, Skin, Cortex, Spinal Cord, Retina

Publications for Tubulin, Beta

Articles related to Tubulin, Beta:

(show top 50) (show all 311)
# Title Authors PMID Year
1
ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression. 61
31187490 2020
2
Proteome of cat semen obtained after urethral catheterization. 61
31518731 2020
3
Early expression of Tubulin Beta-III in avian cranial neural crest cells. 61
31369820 2019
4
CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis. 61
31818185 2019
5
Targeted genomic integration of EGFP under tubulin beta 3 class III promoter and mEos2 under tryptophan hydroxylase 2 promoter does not produce sufficient levels of reporter gene expression. 61
31106442 2019
6
RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. 61
30957628 2019
7
Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden and PD-L1 expression in cancer patients. 61
31479512 2019
8
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease. 61
31462148 2019
9
Chronic mild stress leads to aberrant glucose energy metabolism in depressed Macaca fascicularis models. 61
31108306 2019
10
TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction. 61
30767704 2019
11
Selection and validation of appropriate reference genes for real-time quantitative PCR analysis in Momordica charantia. 61
31054374 2019
12
Long-term iron exposure causes widespread molecular alterations associated with memory impairment in mice. 61
31136779 2019
13
FOCAD loss impacts microtubule assembly, G2/M progression and patient survival in astrocytic gliomas. 61
31473790 2019
14
MIR145-3p promotes autophagy and enhances bortezomib sensitivity in multiple myeloma by targeting HDAC4. 61
31242129 2019
15
Selectively high efficacy of eribulin against high-grade invasive recurrent and/or metastatic squamous cell carcinoma of the head and neck. 61
31186718 2019
16
2,3',4,4',5-Pentachlorobiphenyl induced autophagy of the thyrocytes via DAPK2/PKD/VPS34 pathway. 61
31020377 2019
17
PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. 61
31177901 2019
18
Proteomic characterization of early lung response to breast cancer metastasis in mice. 61
30763573 2019
19
Protease-activated receptor-2 regulates glial scar formation via JNK signaling. 61
30628825 2019
20
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells. 61
30990357 2019
21
Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). 61
30983487 2019
22
Integrative Analyses of Genes Associated with Subcutaneous Insulin Resistance. 61
30678306 2019
23
Gene Expression and DNA Methylation Alterations During Non-alcoholic Steatohepatitis-Associated Liver Carcinogenesis. 61
31191608 2019
24
Identification of Ocular Autoantigens Associated With Juvenile Idiopathic Arthritis-Associated Uveitis. 61
31447836 2019
25
TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology. 61
30446499 2018
26
Primordial germ cells do not migrate along nerve fibres in marmoset monkey and mouse embryos 61
30390611 2018
27
Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol. 61
30497457 2018
28
Proteome of the periovulatory oviduct and uterus of goats as related to nutritional balance. 61
29885005 2018
29
Mutation analysis of the TUBB8 gene in primary infertile women with arrest in oocyte maturation. 61
29671363 2018
30
Novel aminochromone derivative inhibits tumor growth on xenograft model of lung cancer in mice. 61
30637230 2018
31
Human oocyte maturation arrest caused by a novel missense mutation in TUBB8. 61
29877102 2018
32
Investigation of serum biomarkers in primary gout patients using iTRAQ-based screening. 61
29600944 2018
33
miRNA-125b-5p Suppresses Hypothyroidism Development by Targeting Signal Transducer and Activator of Transcription 3. 61
30027933 2018
34
Identification of differentially regulated deceitful proteins in SH-SY5Y cells engineered with Tet-regulated protein expression system. 61
29600520 2018
35
A novel mutation in the TUBB8 gene is associated with complete cleavage failure in fertilized eggs. 61
29704226 2018
36
Postmortem Diagnostic Exome Sequencing Identifies a De Novo TUBB3 Alteration in a Newborn With Prenatally Diagnosed Hydrocephalus and Suspected Walker-Warburg Syndrome. 61
29187032 2018
37
Dystonia-4 (DYT4)-associated TUBB4A mutants exhibit disorganized microtubule networks and inhibit neuronal process growth. 61
29127012 2018
38
Structural study of the bladder in fetuses with prune belly syndrome. 61
28598513 2018
39
Mitochondrial distribution violation and nuclear indentations in neurons differentiated from iPSCs of Huntington's disease patients. 61
30679892 2018
40
TUBB4A mutations result in specific neuronal and oligodendrocytic defects that closely match clinically distinct phenotypes. 61
28973395 2017
41
Promotion of the Unfolding Protein Response in Orexin/Dynorphin Neurons in Sudden Infant Death Syndrome (SIDS): Elevated pPERK and ATF4 Expression. 61
27796753 2017
42
Coordinate expression of pan-neuronal and functional signature genes in sympathetic neurons. 61
28936781 2017
43
Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization. 61
28814507 2017
44
Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages. 61
28648944 2017
45
Mutation analysis of the TUBB8 gene in nine infertile women with oocyte maturation arrest. 61
28652098 2017
46
Editor's Highlight: Development of Novel Neural Embryonic Stem CellTests for High-Throughput Screening of Embryotoxic Chemicals. 61
28903496 2017
47
Transcriptional profiling of human neural precursors post alcohol exposure reveals impaired neurogenesis via dysregulation of ERK signaling and miR-145. 61
28833141 2017
48
Identification of Endogenous Reference Genes for RT-qPCR Expression Analysis in Urochloa brizantha Under Abiotic Stresses. 61
28819216 2017
49
Early-life decline in neurogenesis markers and age-related changes of TrkB splice variant expression in the human subependymal zone. 61
28612959 2017
50
[A report of atypical hypomyelinating leukodystrophy with atrophy of the basal ganglia and cerebellum caused by a de novo mutation in tubulin beta 4A (TUBB4A) gene and literature review]. 61
28592043 2017

Variations for Tubulin, Beta

Expression for Tubulin, Beta

Search GEO for disease gene expression data for Tubulin, Beta.

Pathways for Tubulin, Beta

Pathways related to Tubulin, Beta according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B TUBB2A
2
Show member pathways
12.43 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B TUBB2A
3
Show member pathways
12.33 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
4 12.33 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
5
Show member pathways
12.29 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
6
Show member pathways
12.24 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
7 12.24 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
8
Show member pathways
12.22 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
9
Show member pathways
12.11 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B TUBB2A
10 11.92 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
11 11.79 TUBB3 TUBB2A TUBB1
12
Show member pathways
11.64 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
13 11.25 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B

GO Terms for Tubulin, Beta

Cellular components related to Tubulin, Beta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.91 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
2 extracellular exosome GO:0070062 9.76 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2A
3 cytoskeleton GO:0005856 9.61 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
4 azurophil granule lumen GO:0035578 9.37 TUBB4B TUBB
5 extracellular vesicle GO:1903561 9.32 TUBB4B TUBB2A
6 microtubule GO:0005874 9.28 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B

Biological processes related to Tubulin, Beta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based process GO:0007017 9.81 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
2 cytoskeleton organization GO:0007010 9.73 TUBB8 TUBB6 TUBB4A TUBB3 TUBB2B TUBB
3 mitotic cell cycle GO:0000278 9.61 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
4 G2/M transition of mitotic cell cycle GO:0000086 9.58 TUBB4B TUBB4A TUBB
5 ciliary basal body-plasma membrane docking GO:0097711 9.54 TUBB4B TUBB4A TUBB
6 regulation of G2/M transition of mitotic cell cycle GO:0010389 9.5 TUBB4B TUBB4A TUBB
7 spindle assembly GO:0051225 9.46 TUBB1 TUBB
8 natural killer cell mediated cytotoxicity GO:0042267 9.43 TUBB4B TUBB
9 microtubule cytoskeleton organization GO:0000226 9.28 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B

Molecular functions related to Tubulin, Beta according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.81 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
2 structural constituent of cytoskeleton GO:0005200 9.61 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
3 nucleotide binding GO:0000166 9.5 TUBB4B TUBB4A TUBB
4 GTPase activity GO:0003924 9.28 TUBB8 TUBB6 TUBB4B TUBB4A TUBB3 TUBB2B
5 MHC class I protein binding GO:0042288 9.26 TUBB4B TUBB

Sources for Tubulin, Beta

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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