MCID: TLR001
MIFTS: 56

Tularemia

Categories: Infectious diseases, Mental diseases, Rare diseases, Skin diseases

Aliases & Classifications for Tularemia

MalaCards integrated aliases for Tularemia:

Name: Tularemia 12 73 20 58 3 15 17 70
Francisella Tularensis Infection 20 3
Pahvant Valley Plague 20
Deerfly Fever 20
Lemming Fever 20
Ohara Disease 20
Rabbit Fever 20
Yatobyo 20

Characteristics:

Orphanet epidemiological data:

58
tularemia
Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),<1/1000000 (Netherlands),1-9/100000 (Sweden),1-9/100000 (Czech Republic),1-9/100000 (Finland),1-9/1000000 (Austria),<1/1000000 (Belgium),<1/1000000 (Denmark),1-9/1000000 (Croatia),1-9/1000000 (Bulgaria),<1/1000000 (Estonia),<1/1000000 (France),<1/1000000 (Germany),<1/1000000 (Italy),1-9/1000000 (Latvia),<1/1000000 (Lithuania),<1/1000000 (Poland),<1/1000000 (Romania),<1/1000000 (Slovenia),1-9/1000000 (Switzerland),1-9/1000000 (Spain),1-9/100000 (Norway); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Tularemia

CDC : 3 Tularemia is a disease that can infect animals and people. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. People can become infected in several ways, including: Tick and deer fly bites Skin contact with infected animals Drinking contaminated water Inhaling contaminated aerosols or agricultural and landscaping dust Laboratory exposure In addition, people could be exposed as a result of bioterrorism. Symptoms vary depending how the person was infected. Tularemia can be life-threatening, but most infections can be treated successfully with antibiotics. Steps to prevent tularemia include: Using insect repellent Wearing gloves when handling sick or dead animals Avoiding mowing over dead animals In the United States, naturally occurring infections have been reported from all states except Hawaii.

MalaCards based summary : Tularemia, also known as francisella tularensis infection, is related to oculoglandular tularemia and ulceroglandular tularemia. An important gene associated with Tularemia is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung, and related phenotypes are fever and arthralgia

Disease Ontology : 12 A primary bacterial infectious disease that has material basis in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues.

GARD : 20 Tularemia is an infection caused by the bacterium Francisella tularensis. It is more common in rodents and rabbits but has been found in other animals including domestic cats, sheep, birds, and hamsters. Humans can become infected in several different ways: by handling infected animals, through tick or deer fly bites, by drinking contaminated water, or by inhaling contaminated dust or aerosols. Person-to-person transmission has not been reported. The type of tularemia and the particular signs and symptoms vary depending on how the bacteria enter the body. However, fever is seen in most cases. Though tularemia can be life-threatening, most infections can be treated with antibiotics.

Wikipedia : 73 Tularemia, also known as rabbit fever, is an infectious disease caused by the bacterium Francisella... more...

Related Diseases for Tularemia

Diseases related to Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 588)
# Related Disease Score Top Affiliating Genes
1 oculoglandular tularemia 32.6 TLR2 PDP1 CLPB
2 ulceroglandular tularemia 32.6 SCGB1D1 PDP1 PDE6B
3 typhoidal tularemia 32.4 SCGB1D1 PDP1 PDE6B CLPB
4 gastrointestinal tularemia 32.3 TLR4 TLR2 SLC11A1 PDP1 CLPB
5 brucellosis 31.1 TNF TLR4 SLC11A1
6 pneumonic tularemia 30.6 TNF TLR4 TLR2 SCGB1D1 IL1B FTL
7 cervical adenitis 30.5 PDE6B IL1B HSPD1 CD4
8 suppurative lymphadenitis 30.4 PDE6B CD4 CCR6
9 leptospirosis 30.4 TNF TLR2 IL1B
10 tonsillitis 30.3 TNF TLR4 TLR2 IL1B
11 lymphadenitis 30.3 TNF TLR4 SLC11A1 IL1B CD4 CCR6
12 conjunctivitis 30.3 TNF TLR4 NLRC4
13 variola major 30.3 CD8A CD4
14 pharyngitis 30.2 TNF IL1B CD8A CD4
15 endocarditis 30.1 TNF TLR2 HSPD1
16 plague 30.1 TNF TLR4 TLR2 IL1B CD8A CD4
17 lyme disease 30.1 TNF TLR2 IL1B HSPD1
18 typhoid fever 30.0 TNF TLR4 SLC11A1 IL1B CCR6 CASP1
19 dacryoadenitis 30.0 CD8A CD4 CCR6
20 ehrlichiosis 30.0 HSPD1 CD8A CD4
21 pericarditis 29.9 TNF P2RX7 IL1B
22 pneumonia 29.9 TNF TLR4 TLR2 MBL2 IL1B
23 melioidosis 29.9 TNF TLR4 TLR2
24 pulmonary tuberculosis 29.9 TNF TLR2 SLC11A1 P2RX7 MBL2
25 epidemic typhus 29.8 TNF HSPD1 CD8A CD4
26 prosthetic joint infection 29.8 TLR4 TLR2 MBL2 IL1B
27 cellulitis 29.8 TNF CD8A CD4 CCR6
28 syphilis 29.8 TNF CD8A CD4 CCR6
29 q fever 29.8 TNF TLR4 TLR2 SLC11A1 P2RX7 MBL2
30 extrapulmonary tuberculosis 29.7 TLR2 SLC11A1 P2RX7 MBL2 IL1B
31 scrub typhus 29.7 TNF TLR4 TLR2 IL1B
32 glanders 29.7 TLR4 HSPD1 CD8A CD4
33 exanthem 29.7 TNF IL1B CD8A CD4 CCR6
34 pleurisy 29.7 TNF TLR4 TLR2
35 bronchopneumonia 29.7 TNF TLR4 IL1B CD8A CD4
36 coccidioidomycosis 29.7 TLR4 MBL2 CD4 CCR6
37 allergic disease 29.7 TNF TLR4 TLR2 IL1B CCR6
38 aortitis 29.6 TNF IL1B CD4
39 neutropenia 29.6 TNF MBL2 IL1B CLPB
40 bronchiectasis 29.6 TNF TLR2 MBL2 IL1B
41 pyelonephritis 29.6 TNF TLR4 IL1B
42 granulomatous hepatitis 29.6 TNF CD8A CD4
43 enterocolitis 29.6 TNF TLR4 NLRC4
44 hantavirus hemorrhagic fever with renal syndrome 29.6 TNF CD8A CD4
45 meningitis 29.5 TNF TLR4 TLR2 MBL2 IL1B CASP1
46 rubella 29.5 TNF TLR4 IL1B
47 chronic granulomatous disease 29.5 TNF SLC11A1 IL1B CASP1
48 bilirubin metabolic disorder 29.5 TNF IL1B CD8A CD4
49 viral hepatitis 29.5 TNF TLR4 TLR2 IL1B
50 sarcoidosis 1 29.5 TNF SLC11A1 IL1B CD8A CD4 CCR6

Graphical network of the top 20 diseases related to Tularemia:



Diseases related to Tularemia

Symptoms & Phenotypes for Tularemia

Human phenotypes related to Tularemia:

58 31 (show all 40)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
2 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
3 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
4 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
5 tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0001649
6 pneumonia 58 31 frequent (33%) Frequent (79-30%) HP:0002090
7 leukocytosis 58 31 frequent (33%) Frequent (79-30%) HP:0001974
8 chills 58 31 frequent (33%) Frequent (79-30%) HP:0025143
9 asthenia 58 31 frequent (33%) Frequent (79-30%) HP:0025406
10 increased circulating antibody level 31 frequent (33%) HP:0010702
11 anemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001903
12 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
13 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
14 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
15 respiratory distress 58 31 occasional (7.5%) Occasional (29-5%) HP:0002098
16 pleural effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0002202
17 pulmonary infiltrates 58 31 occasional (7.5%) Occasional (29-5%) HP:0002113
18 cervical lymphadenopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0025289
19 oral ulcer 58 31 occasional (7.5%) Occasional (29-5%) HP:0000155
20 neck pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0030833
21 localized skin lesion 58 31 occasional (7.5%) Occasional (29-5%) HP:0011355
22 pharyngitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0025439
23 behavioral abnormality 58 31 very rare (1%) Very rare (<4-1%) HP:0000708
24 otitis media 58 31 very rare (1%) Very rare (<4-1%) HP:0000388
25 conjunctivitis 58 31 very rare (1%) Very rare (<4-1%) HP:0000509
26 meningitis 58 31 very rare (1%) Very rare (<4-1%) HP:0001287
27 mediastinal lymphadenopathy 58 31 very rare (1%) Very rare (<4-1%) HP:0100721
28 confusion 58 31 very rare (1%) Very rare (<4-1%) HP:0001289
29 erythema nodosum 58 31 very rare (1%) Very rare (<4-1%) HP:0012219
30 ocular pain 58 31 very rare (1%) Very rare (<4-1%) HP:0200026
31 brain abscess 58 31 very rare (1%) Very rare (<4-1%) HP:0030049
32 conjunctival hyperemia 58 31 very rare (1%) Very rare (<4-1%) HP:0030953
33 cutaneous abscess 58 31 very rare (1%) Very rare (<4-1%) HP:0031292
34 abnormal nasopharyngeal adenoid morphology 31 very rare (1%) HP:3000033
35 abnormality of the nervous system 58 Very rare (<4-1%)
36 inflammatory abnormality of the eye 58 Very rare (<4-1%)
37 increased antibody level in blood 58 Frequent (79-30%)
38 lymphadenopathy 58 Occasional (29-5%)
39 abnormal pulmonary thoracic imaging finding 58 Occasional (29-5%)
40 abnormality of nasopharyngeal adenoids 58 Very rare (<4-1%)

MGI Mouse Phenotypes related to Tularemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.19 AIM2 CASP1 CCR6 CD4 CD8A FTL
2 cellular MP:0005384 10.1 AIM2 CASP1 CD4 CD8A HSPD1 NLRC4
3 homeostasis/metabolism MP:0005376 10.03 AIM2 CASP1 CCR6 CD4 FTL IL1B
4 immune system MP:0005387 9.83 AIM2 CASP1 CCR6 CD4 CD8A FTL
5 integument MP:0010771 9.4 CASP1 CD4 CD8A HSPD1 IL1B P2RX7

Drugs & Therapeutics for Tularemia

Drugs for Tularemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2
2 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Longitudinal Phase 2 Study for the Continued Evaluation of the Safety and Immunogenicity of a Live Francisella Tularensis Vaccine, NDBR 101, Lot 4 Completed NCT00584844 Phase 2
2 A Phase II, Multi-Center, Double-Blind, Randomized Trial Comparing the Safety and Immunogenicity of a Francisella Tularensis Live Vaccine Strain (LVS) Vaccine Produced by DynPort Vaccine Company (DVC-LVS) to a LVS Vaccine in Use by the United States Army Medical Research Institute of Infectious Diseases (USAMRIID-LVS) Completed NCT01150695 Phase 2
3 A Longitudinal Phase 2 Study for the Continued Evaluation of the Safety and Immunogenicity of a Live Francisella Tularensis Vaccine, NDBR 101, Lot 4 in Healthy Adults At-Risk for Exposure to Francisella Tularensis Enrolling by invitation NCT00787826 Phase 2
4 Phase 2 Open-Label Safety and Immunogenicity Study of Tularemia Vaccine, Live, Attenuated (NDBR 101, Lot 4) in Adult Subjects at Risk of Exposure to Tularemia Bacteria Not yet recruiting NCT03867162 Phase 2

Search NIH Clinical Center for Tularemia

Genetic Tests for Tularemia

Anatomical Context for Tularemia

MalaCards organs/tissues related to Tularemia:

40
Skin, Bone, Lung, Lymph Node, T Cells, Kidney, Eye

Publications for Tularemia

Articles related to Tularemia:

(show top 50) (show all 3133)
# Title Authors PMID Year
1
Amoebae can promote the survival of Francisella species in the aquatic environment. 61
33538648 2021
2
Tularemia in Children. 61
33399432 2021
3
Francisella tularensis human infections in a village of northwest Iran. 61
33789598 2021
4
Identification of MHC Class I bound peptides of Francisella tularensis Live Vaccine Strain using mass spectrometry. 61
33238185 2021
5
Finafloxacin is an effective treatment for inhalational tularemia and plague in mouse models of infection. 61
33753342 2021
6
Central Nervous System Vasculitis Due to an Endemic Zoonosis in Turkey; Tularemia. 61
33795957 2021
7
Analyses of tularemia cases and their long-term results. 61
33797535 2021
8
Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19-like disease in hamsters. 61
33785745 2021
9
Likely Geographic Distributional Shifts among Medically Important Tick Species and Tick-Associated Diseases under Climate Change in North America: A Review. 61
33807736 2021
10
Survey on tick distribution and tick-borne pathogens in Daejeon and adjacent areas in South Korea. 61
33774480 2021
11
A Case Report of Oculoglandular Tularemia-Chasing Zebras Among Potential Diagnoses. 61
32949503 2021
12
Utilization of a tetracycline-inducible system for high-level expression of recombinant proteins in Francisella tularensis LVS. 61
33610608 2021
13
Francisella tularensis survey among ranchers and livestock in western Iran. 61
33302236 2021
14
A Rare Case of Spontaneous Splenic Rupture Secondary to Tularemia Following a Cat Bite. 61
33717752 2021
15
[Mediastinal lymphadenopathy: Do not forget tularemia!] 61
33581986 2021
16
Tularemia: a re-emerging tick-borne infectious disease. 61
32989563 2021
17
Factors Affecting Cervical Lymph Node Suppuration in Oropharyngeal Tularemia Cases. 61
33645188 2021
18
Characterization of Tularemia Cases in Slovenia with Multiple-Locus Variable-Number Tandem Repeat Analysis. 61
33601964 2021
19
High-resolution melting PCR assay as a powerful tool for the epidemiological surveillance of tularemia in Western Europe. 61
33556556 2021
20
Long-Term Survival of Virulent Tularemia Pathogens outside a Host in Conditions That Mimic Natural Aquatic Environments. 61
33397692 2021
21
A Francisella tularensis L,D-carboxypeptidase plays important roles in cell morphology, envelope integrity, and virulence. 61
33469978 2021
22
Structural and functional analysis of the Francisella lysine decarboxylase as a key actor in oxidative stress resistance. 61
33441661 2021
23
Dose-Response Modeling: Extrapolating From Experimental Data to Real-World Populations. 61
32966638 2021
24
Neurologic Manifestations of the World Health Organization's List of Pandemic and Epidemic Diseases. 61
33692745 2021
25
Vector-borne diseases in Iran: epidemiology and key challenges. 61
33438476 2021
26
A Space-Time Permutation Scan Statistic for Evaluating County-Level Tickborne Disease Clusters in Indiana, 2009-2016. 61
33156708 2021
27
Inguinal Ulceroglandular Tularemia Caused by Francisella tularensis Subspecies holarctica, Canada. 61
33755005 2021
28
A Francisella tularensis Chitinase Contributes to Bacterial Persistence and Replication in Two Major U.S. Tick Vectors. 61
33321814 2020
29
Molecular Characterisation of Cytochrome Oxidase I and Internal Transcribed Spacer 2 Fragments of Culiseta longiareolata. 61
33269558 2020
30
Evaluation of the Biotoxis qPCR Detection Kit for Francisella tularensis Detection in Clinical and Environmental Samples. 61
33115844 2020
31
Genotyping of Francisella tularensis subsp. holarctica from Hares in Germany. 61
33291395 2020
32
Behavioral characteristics and endosymbionts of two potential tularemia and Rocky Mountain spotted fever tick vectors. 61
33207056 2020
33
Exploring the Niche of Rickettsia montanensis (Rickettsiales: Rickettsiaceae) Infection of the American Dog Tick (Acari: Ixodidae), Using Multiple Species Distribution Model Approaches. 61
33274379 2020
34
Characterization of Schu S4 aro mutants as live attenuated tularemia vaccine candidates. 61
32241221 2020
35
Tularemia as a Mosquito-Borne Disease. 61
33374861 2020
36
Tularemia in Children and Adolescents. 61
33003104 2020
37
Virulence of Francisella tularensis Subspecies holarctica Biovar japonica and Phenotypic Change during Serial Passages on Artificial Media. 61
33261098 2020
38
Complete Genome Sequences of Two Strains of Francisella tularensis subsp. holarctica bv. japonica. 61
33154017 2020
39
Complete Genome Sequences of Allofrancisella inopinata SYSU YG23 and Allofrancisella frigidaquae SYSU 10HL1970, Isolated from Water from Cooling Systems in China. 61
33239460 2020
40
Genetic Traces of the Francisella tularensis Colonization of Spain, 1998-2020. 61
33202547 2020
41
Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19 disease in hamsters. 61
33236013 2020
42
Erratum: Blume, C., et al. Modulation of Human Airway Barrier Functions during Burkholderia thailandensis and Francisella tularensis Infection Running Title: Airway Barrier Functions during Bacterial Infections. Pathogens 2016, 5, 53. 61
33256268 2020
43
Tularemia: A Case Series of Patients Diagnosed at the National Reference Center for Rickettsioses From 2008 to 2017. 61
33209946 2020
44
Atg5-Deficient Mice Infected with Francisella tularensis LVS Demonstrate Increased Survival and Less Severe Pathology in Internal Organs. 61
33036147 2020
45
Control of Francisellatularensis Virulence at Gene Level: Network of Transcription Factors. 61
33096715 2020
46
The Sensor Kinase QseC Regulates the Unlinked PmrA Response Regulator and Downstream Gene Expression in Francisella. 61
32839173 2020
47
Transcriptome Sequencing Data Sets of Human Lung Epithelial Cells in the Course of Francisella tularensis Infection. 61
33060276 2020
48
Mechanisms Affecting the Acquisition, Persistence and Transmission of Francisella tularensis in Ticks. 61
33114018 2020
49
Emerging Natural Focal Infectious Diseases in Russia: A Medical-Geographical Study. 61
33143199 2020
50
Genetic engineering and bacterial pathogenesis against the vectorial capacity of mosquitoes. 61
32679245 2020

Variations for Tularemia

Expression for Tularemia

Search GEO for disease gene expression data for Tularemia.

Pathways for Tularemia

Pathways related to Tularemia according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 TNF TLR4 TLR2 SLC11A1 P2RX7 NLRC4
2
Show member pathways
13.15 TNF TLR4 TLR2 PPARA MBL2 IL1B
3
Show member pathways
12.81 TNF IL1B HSPD1 CD8A CD4
4
Show member pathways
12.78 TNF TLR4 TLR2 IL1B CASP1
5
Show member pathways
12.72 TNF TLR4 TLR2 NLRC4 IL1B CASP1
6
Show member pathways
12.58 TNF TLR4 TLR2 IL1B CD4
7
Show member pathways
12.57 TNF TLR4 TLR2 IL1B CASP1
8 12.55 TNF TLR2 IL1B CD8A AIM2
9
Show member pathways
12.53 TNF TLR4 TLR2 IL1B CD8A CD4
10 12.4 TNF TLR4 NLRC4 IL1B CASP1
11
Show member pathways
12.3 TLR2 SLC11A1 CD4 CCR6
12
Show member pathways
12.23 TNF TLR4 TLR2 IL1B
13
Show member pathways
12.21 TNF TLR4 TLR2 P2RX7 NLRC4 IL1B
14 12.19 TNF TLR4 TLR2 IL1B HSPD1
15
Show member pathways
12.17 TNF TLR4 TLR2 IL1B
16
Show member pathways
12.12 TNF TLR4 IL1B FTL CASP1
17
Show member pathways
11.99 P2RX7 NLRC4 CASP1 AIM2
18 11.96 TNF TLR4 P2RX7 NLRC4 IL1B CASP1
19 11.93 TNF TLR4 TLR2 IL1B
20 11.9 TNF IL1B CD8A CD4
21 11.86 TNF TLR4 TLR2 IL1B
22
Show member pathways
11.84 TLR4 TLR2 IL1B CD4
23 11.75 TNF TLR4 IL1B CASP1
24 11.72 TNF IL1B CD8A CD4
25 11.67 TNF IL1B CD8A CD4 CCR6
26 11.64 TNF TLR4 TLR2 CCR6
27 11.64 TNF TLR4 NLRC4 IL1B CD8A CD4
28
Show member pathways
11.6 TNF TLR4 TLR2 IL1B CD4
29 11.48 TNF TLR4 TLR2 IL1B
30 11.44 TNF TLR4 TLR2 IL1B
31 11.35 TNF TLR4 IL1B
32 11.32 NLRC4 IL1B CASP1 AIM2
33 11.26 TNF IL1B CD4
34 11.1 TNF IL1B CASP1
35 10.92 TNF TLR4 TLR2 NLRC4 IL1B HSPD1
36 10.5 IL1B CASP1

GO Terms for Tularemia

Cellular components related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.77 TNF TLR4 CD8A CD4 CCR6
2 membrane raft GO:0045121 9.71 TNF TLR2 HSPD1 CD4
3 integral component of plasma membrane GO:0005887 9.56 TNF TLR4 TLR2 SLC11A1 P2RX7 CD8A
4 AIM2 inflammasome complex GO:0097169 9.32 CASP1 AIM2
5 IPAF inflammasome complex GO:0072557 9.26 NLRC4 CASP1
6 cell surface GO:0009986 9.17 TNF TLR4 TLR2 MBL2 HSPD1 CD4
7 lipopolysaccharide receptor complex GO:0046696 9.16 TLR4 HSPD1

Biological processes related to Tularemia according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.12 TLR4 TLR2 NLRC4 MBL2 CD8A CD4
2 positive regulation of gene expression GO:0010628 10.07 TNF TLR4 TLR2 SLC11A1 P2RX7 IL1B
3 inflammatory response GO:0006954 9.98 TNF TLR4 TLR2 SLC11A1 NLRC4 IL1B
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 TNF TLR4 CD4 CASP1
5 defense response to bacterium GO:0042742 9.97 TNF TLR4 SLC11A1 NLRC4 MBL2
6 response to hypoxia GO:0001666 9.96 TLR2 PPARA HSPD1 CASP1
7 cellular response to lipopolysaccharide GO:0071222 9.96 TNF TLR4 IL1B CASP1
8 defense response to Gram-negative bacterium GO:0050829 9.87 TLR4 SLC11A1 CD4
9 positive regulation of JNK cascade GO:0046330 9.86 TNF TLR4 IL1B
10 cellular response to mechanical stimulus GO:0071260 9.86 TLR4 IL1B CASP1
11 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.85 TNF NLRC4 HSPD1 CASP1
12 positive regulation of cytokine production GO:0001819 9.84 TNF SLC11A1 CASP1
13 positive regulation of phagocytosis GO:0050766 9.82 TNF SLC11A1 IL1B
14 T cell activation GO:0042110 9.82 HSPD1 CD8A CD4
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 TNF TLR4 IL1B
16 apoptotic signaling pathway GO:0097190 9.81 TNF TLR4 P2RX7 CASP1
17 positive regulation of interleukin-12 production GO:0032735 9.8 TLR4 TLR2 HSPD1
18 positive regulation of chemokine production GO:0032722 9.8 TNF TLR4 TLR2
19 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 TNF TLR4 TLR2 IL1B
20 positive regulation of inflammatory response GO:0050729 9.8 TNF TLR4 TLR2 IL1B HSPD1
21 response to lipopolysaccharide GO:0032496 9.8 TLR4 TLR2 SLC11A1 IL1B HSPD1 CASP1
22 positive regulation of interleukin-10 production GO:0032733 9.79 TLR4 TLR2 HSPD1
23 positive regulation of interleukin-8 production GO:0032757 9.78 TNF TLR4 TLR2 IL1B
24 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.77 TLR4 TLR2 HSPD1
25 positive regulation of interleukin-6 production GO:0032755 9.77 TNF TLR4 TLR2 IL1B HSPD1
26 activation of innate immune response GO:0002218 9.76 TLR4 NLRC4 AIM2
27 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 TNF TLR4 TLR2 IL1B
28 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 TNF TLR4 TLR2 NLRC4 IL1B AIM2
29 response to ATP GO:0033198 9.71 P2RX7 HSPD1 CASP1
30 positive regulation of neuroinflammatory response GO:0150078 9.7 TNF IL1B
31 pyroptosis GO:0070269 9.7 NLRC4 CASP1 AIM2
32 I-kappaB phosphorylation GO:0007252 9.69 TLR4 TLR2
33 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.68 TNF TLR4
34 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
35 cellular response to lipoteichoic acid GO:0071223 9.68 TLR4 TLR2
36 interleukin-1 beta production GO:0032611 9.67 TLR4 CASP1
37 vascular endothelial growth factor production GO:0010573 9.67 TNF IL1B
38 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
39 sequestering of triglyceride GO:0030730 9.63 TNF IL1B
40 positive regulation of matrix metallopeptidase secretion GO:1904466 9.61 TLR4 TLR2
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 TNF IL1B
42 immune response GO:0006955 9.61 TNF TLR4 TLR2 SLC11A1 IL1B CD8A
43 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.56 TLR4 TLR2
44 positive regulation of interferon-gamma production GO:0032729 9.55 TNF TLR4 SLC11A1 IL1B HSPD1
45 positive regulation of interleukin-1 beta production GO:0032731 9.1 TNF TLR4 P2RX7 NLRC4 CASP1 AIM2

Molecular functions related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.3 TNF TLR4 TLR2 SCGB1D1 PPARA PDP1
2 identical protein binding GO:0042802 9.81 TNF TLR4 TLR2 P2RX7 NLRC4 FTL
3 signaling receptor activity GO:0038023 9.35 TLR4 TLR2 PPARA CD4 CCR6
4 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
5 lipopolysaccharide binding GO:0001530 8.92 TLR4 TLR2 P2RX7 HSPD1

Sources for Tularemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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