MCID: TLR001
MIFTS: 44

Tularemia

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Tularemia

MalaCards integrated aliases for Tularemia:

Name: Tularemia 12 76 53 59 3 44 15 73
Francisella Tularensis Infection 53
Pahvant Valley Plague 53
Deerfly Fever 53
Lemming Fever 53
Ohara Disease 53
Rabbit Fever 53
Yatobyo 53

Characteristics:

Orphanet epidemiological data:

59
tularemia
Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),<1/1000000 (Netherlands),1-9/100000 (Sweden),1-9/100000 (Czech Republic),1-9/100000 (Finland),1-9/1000000 (Austria),<1/1000000 (Belgium),<1/1000000 (Denmark),1-9/1000000 (Croatia),1-9/1000000 (Bulgaria),<1/1000000 (Estonia),<1/1000000 (France),<1/1000000 (Germany),<1/1000000 (Italy),1-9/1000000 (Latvia),<1/1000000 (Lithuania),<1/1000000 (Poland),<1/1000000 (Romania),<1/1000000 (Slovenia),1-9/1000000 (Switzerland),1-9/1000000 (Spain),1-9/100000 (Norway); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2123
ICD9CM 35 021.8
MeSH 44 D014406
Orphanet 59 ORPHA3392
ICD10 via Orphanet 34 A21.0 A21.1 A21.2 more
MESH via Orphanet 45 D014406
UMLS via Orphanet 74 C0041351

Summaries for Tularemia

NIH Rare Diseases : 53 Tularemia is an infection caused by the bacterium Francisella tularensis. It is more common in rodents and rabbits but has been found in other animals including domestic cats, sheep, birds, and hamsters. Humans can become infected in several different ways: by handling infected animals, through tick or deer fly bites, by drinking contaminated water, or by inhaling contaminated dust or aerosols. Person-to-person transmission has not been reported. The type of tularemia and the particular signs and symptoms vary depending on how the bacteria enter the body. However, fever is seen in most cases. Though tularemia can be life-threatening, most infections can be treated with antibiotics.

MalaCards based summary : Tularemia, also known as francisella tularensis infection, is related to pneumonic tularemia and ulceroglandular tularemia. An important gene associated with Tularemia is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes.

Disease Ontology : 12 A primary bacterial infectious disease that has material basis in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues.

CDC : 3 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Wikipedia : 76 Tularemia, also known as rabbit fever, is an infectious disease caused by the bacterium Francisella... more...

Related Diseases for Tularemia

Diseases related to Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 pneumonic tularemia 33.6 FTL STAB2 TLR2
2 ulceroglandular tularemia 32.2 CASP1 PDE6B STAB2
3 oculoglandular tularemia 12.3
4 glandular tularemia 12.3
5 typhoidal tularemia 12.3
6 gastrointestinal tularemia 12.2
7 tick infestation 11.2
8 prosthetic joint infection 10.4 MBL2 TLR2
9 nontuberculous mycobacterial lung disease 10.4 SLC11A1 TLR2
10 neisseria meningitidis infection 10.4 MBL2 TLR2
11 rheumatic fever 10.3 MBL2 TLR2
12 bacterial vaginosis 10.3 MBL2 TLR2
13 plague 10.2
14 cervicitis 10.2
15 lymphadenitis 10.2
16 pneumonia 10.2
17 cervical adenitis 10.1
18 q fever 10.0
19 leptospirosis 10.0
20 spotted fever 10.0
21 hepatitis 9.9
22 rocky mountain spotted fever 9.9
23 brucellosis 9.9
24 pharyngitis 9.9
25 influenza 9.9
26 extrapulmonary tuberculosis 9.9 MBL2 P2RX7 SLC11A1 TLR2
27 leprosy 3 9.9 HSPE1 SLC11A1 TLR2
28 pulmonary tuberculosis 9.8 MBL2 P2RX7 SLC11A1 TLR2
29 lymphoma 9.8
30 endocarditis 9.8
31 tick paralysis 9.8
32 listeriosis 9.8
33 smallpox 9.8
34 meningitis 9.8
35 transmitted_by 9.8
36 typhoid fever 9.8 CASP1 SLC11A1
37 legionellosis 9.8 CASP1 TLR2
38 lymphoma, hodgkin, classic 9.7
39 psoriatic arthritis 9.7
40 myocardial infarction 9.7
41 legionnaire disease 9.7
42 graft-versus-host disease 9.7
43 acute myocardial infarction 9.7
44 adult respiratory distress syndrome 9.7
45 arthritis 9.7
46 chronic granulomatous disease 9.7
47 japanese spotted fever 9.7
48 tick-borne encephalitis 9.7
49 erythema multiforme 9.7
50 infective endocarditis 9.7

Graphical network of the top 20 diseases related to Tularemia:



Diseases related to Tularemia

Symptoms & Phenotypes for Tularemia

Drugs & Therapeutics for Tularemia

Drugs for Tularemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Tularemia Vaccine Comparison Completed NCT01150695 Phase 2
2 Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Completed NCT00584844 Phase 2
3 Continued Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Enrolling by invitation NCT00787826 Phase 2

Search NIH Clinical Center for Tularemia

Cochrane evidence based reviews: tularemia

Genetic Tests for Tularemia

Anatomical Context for Tularemia

MalaCards organs/tissues related to Tularemia:

41
Skin, Lymph Node, Testes, T Cells, Myeloid, Neutrophil, Lung

Publications for Tularemia

Articles related to Tularemia:

(show top 50) (show all 634)
# Title Authors Year
1
Human Dose-Response Data for Francisella tularensis and a Dose- and Time-Dependent Mathematical Model of Early-Phase Fever Associated with Tularemia After Inhalation Exposure. ( 29694682 )
2018
2
Re-emerging Tularemia in Some Middle East Countries: What Are the Reasons? ( 29445647 )
2018
3
Tularemia in interepidemic period. ( 29054578 )
2018
4
Towards integrated surveillance of zoonoses: spatiotemporal joint modeling of rodent population data and human tularemia cases in Finland. ( 29976146 )
2018
5
Evaluation of In-House and Commercial Serological Tests for Diagnosis of Human Tularemia. ( 29118164 )
2018
6
Case Report: Atypical Cutaneous Manifestations of Tularemia after Horsefly Bite. ( 29714156 )
2018
7
Tularemia-induced erythema multiforme minor in an 11-year-old girl. ( 29582465 )
2018
8
Simultaneous immunodetection of anthrax, plague and tularemia from blood cultures utilizing multiplexed suspension arrays. ( 29386263 )
2018
9
A case of typhoidal tularemia in a male Japanese farmer. ( 29635071 )
2018
10
An Improved Tobacco Mosaic Virus (TMV)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia. ( 29922267 )
2018
11
Tularemia in Germany-A Re-emerging Zoonosis. ( 29503812 )
2018
12
Treatment-failure tularemia in children. ( 29563944 )
2018
13
Population Genomics of <i>Francisella tularensis</i> subsp. <i>holarctica</i> and its Implication on the Eco-Epidemiology of Tularemia in Switzerland. ( 29623260 )
2018
14
Revisiting <i>Francisella tularensis</i> subsp. <i>holarctica</i>, Causative Agent of Tularemia in Germany With Bioinformatics: New Insights in Genome Structure, DNA Methylation and Comparative Phylogenetic Analysis. ( 29593661 )
2018
15
Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. ( 29725025 )
2018
16
Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent <i>F. tularensis</i> subsp. <i>tularensis</i>. ( 29868510 )
2018
17
The Cynomolgus Macaque Natural History Model of Pneumonic Tularemia for Predicting Clinical Efficacy Under the Animal Rule. ( 29670861 )
2018
18
Difficulty in the Clinical Diagnosis of Tularemia: Highlighting the Importance of a Physical Exam. ( 29686920 )
2018
19
Rare Cause of Pleuropnemonia: Tularemia Disease. ( 29017676 )
2017
20
Clinical Characteristics of Ulceroglandular Tularemia in Two Bulgarian Regions, 2014-2015: a Report of Five Cases. ( 29341950 )
2017
21
A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia. ( 28328947 )
2017
22
Human Cases of Tularemia in Armenia, 1996-2012. ( 28722639 )
2017
23
Irruptive mammal host populations shape tularemia epidemiology. ( 29145508 )
2017
24
Atypical Presentations of Tularemia. ( 28813752 )
2017
25
Prevalence and Seasonality of Fleas Associated With California Ground Squirrels and the Potential Risk of Tularemia in an Outdoor Non-Human Primate Research Facility. ( 29202201 )
2017
26
High-risk regions and outbreak modelling of tularemia in humans. ( 27806741 )
2017
27
First case of severe pneumonic tularemia in an immunocompetent patient in the Netherlands. ( 28956784 )
2017
28
Protection of vaccinated mice against pneumonic tularemia is associated with an early memory sentinel-response in the lung. ( 29102170 )
2017
29
Notes from the Field: Fatal Pneumonic Tularemia Associated with Dog Exposure - Arizona, June 2016. ( 28837551 )
2017
30
A Field Study of Plague and Tularemia in Rodents, Western Iran. ( 28165869 )
2017
31
The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4. ( 27939130 )
2017
32
Tularemia vaccine: Safety, reactogenicity, &amp;quot;Take&amp;quot; skin reactions, and antibody responses following vaccination with a new lot of the Francisella tularensis live vaccine strain - A phase 2 randomized clinical Trial. ( 28750854 )
2017
33
Imaging Findings of Ulceroglandular Tularemia. ( 28580063 )
2017
34
Expansion and retention of pulmonary CD4(+) T cells after prime boost vaccination correlates with improved longevity and strength of immunity against tularemia. ( 28372827 )
2017
35
Usefulness of a single-assay chemiluminescence test (Tularaemia VIRCLIA IgGa88+a88IgM monotest) for the diagnosis of human tularemia. Comparison of five serological tests. ( 29280085 )
2017
36
Tularemia presenting as pulmonary nodules in an immunocompromised patient. ( 28405072 )
2017
37
Severe glandular tularemia in a patient treated with anti-tumour necrosis factor for psoriatic arthritis. ( 28450199 )
2017
38
Sulfonamide inhibition profiles of the I^-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia. ( 28511911 )
2017
39
Anion inhibitors of the I^-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis. ( 28754318 )
2017
40
Necroptotic debris including damaged mitochondria elicits sepsis-like syndrome during late-phase tularemia. ( 28955505 )
2017
41
Tularemia ( 28613655 )
2017
42
Variation in Tularemia Clinical Manifestations-Arkansas, 2009-2013. ( 28480295 )
2017
43
Introduction and persistence of tularemia in Bulgaria. ( 28649303 )
2017
44
Tularemia presenting as suspected necrotic arachnidism. ( 28396776 )
2017
45
Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice. ( 27246117 )
2016
46
Predicting tularemia with clinical, laboratory and demographical findings in the ED. ( 26577431 )
2016
47
The prevalence of tularemia in occupational groups that have contact with animals. ( 27511510 )
2016
48
Intracellular Delivery: Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice (Small 27/2016). ( 27412305 )
2016
49
A Bioluminescent Francisella tularensis SCHU S4 Strain Enables Noninvasive Tracking of Bacterial Dissemination and the Evaluation of Antibiotics in an Inhalational Mouse Model of Tularemia. ( 27671061 )
2016
50
First Pediatric Case of Tularemia after a Coyote Bite. ( 26885419 )
2016

Variations for Tularemia

Expression for Tularemia

Search GEO for disease gene expression data for Tularemia.

Pathways for Tularemia

GO Terms for Tularemia

Cellular components related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 AIM2 inflammasome complex GO:0097169 8.62 AIM2 CASP1

Biological processes related to Tularemia according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.76 AIM2 P2RX7 SLC11A1 TLR2
2 defense response to bacterium GO:0042742 9.72 MBL2 SLC11A1 STAB2
3 response to hypoxia GO:0001666 9.67 CASP1 PPARA TLR2
4 response to lipopolysaccharide GO:0032496 9.62 CASP1 P2RX7 SLC11A1 TLR2
5 positive regulation of interleukin-6 production GO:0032755 9.56 P2RX7 TLR2
6 iron ion homeostasis GO:0055072 9.54 FTL SLC11A1
7 positive regulation of phagocytosis GO:0050766 9.52 MBL2 SLC11A1
8 positive regulation of cytokine secretion GO:0050715 9.51 CASP1 P2RX7
9 response to ATP GO:0033198 9.48 CASP1 P2RX7
10 iron ion transport GO:0006826 9.43 FTL SLC11A1
11 pyroptosis GO:0070269 9.4 AIM2 CASP1
12 positive regulation of interleukin-1 beta production GO:0032731 9.37 AIM2 P2RX7
13 response to bacterium GO:0009617 9.33 CASP1 P2RX7 SLC11A1
14 positive regulation of interleukin-1 alpha secretion GO:0050717 9.26 CASP1 P2RX7
15 positive regulation of interleukin-1 beta secretion GO:0050718 9.13 AIM2 CASP1 P2RX7
16 defense response to Gram-positive bacterium GO:0050830 8.92 MBL2 P2RX7 STAB2 TLR2

Molecular functions related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.73 AIM2 CASP1 CLPB FTL HSPE1 MBL2
2 lipopolysaccharide binding GO:0001530 8.62 P2RX7 TLR2

Sources for Tularemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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