MCID: TLR001
MIFTS: 48

Tularemia

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Tularemia

MalaCards integrated aliases for Tularemia:

Name: Tularemia 12 77 54 60 3 15 17 74
Francisella Tularensis Infection 54
Pahvant Valley Plague 54
Deerfly Fever 54
Lemming Fever 54
Ohara Disease 54
Rabbit Fever 54
Yatobyo 54

Characteristics:

Orphanet epidemiological data:

60
tularemia
Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),<1/1000000 (Netherlands),1-9/100000 (Sweden),1-9/100000 (Czech Republic),1-9/100000 (Finland),1-9/1000000 (Austria),<1/1000000 (Belgium),<1/1000000 (Denmark),1-9/1000000 (Croatia),1-9/1000000 (Bulgaria),<1/1000000 (Estonia),<1/1000000 (France),<1/1000000 (Germany),<1/1000000 (Italy),1-9/1000000 (Latvia),<1/1000000 (Lithuania),<1/1000000 (Poland),<1/1000000 (Romania),<1/1000000 (Slovenia),1-9/1000000 (Switzerland),1-9/1000000 (Spain),1-9/100000 (Norway); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2123
ICD9CM 36 021.8
MESH via Orphanet 46 D014406
ICD10 via Orphanet 35 A21.0 A21.1 A21.2 more
UMLS via Orphanet 75 C0041351
Orphanet 60 ORPHA3392

Summaries for Tularemia

NIH Rare Diseases : 54 Tularemia is an infection caused by the bacterium Francisella tularensis. It is more common in rodents and rabbits but has been found in other animals including domestic cats, sheep, birds, and hamsters. Humans can become infected in several different ways: by handling infected animals, through tick or deer fly bites, by drinking contaminated water, or by inhaling contaminated dust or aerosols. Person-to-person transmission has not been reported. The type of tularemia and the particular signs and symptoms vary depending on how the bacteria enter the body. However, fever is seen in most cases. Though tularemia can be life-threatening, most infections can be treated with antibiotics.

MalaCards based summary : Tularemia, also known as francisella tularensis infection, is related to pneumonic tularemia and ulceroglandular tularemia. An important gene associated with Tularemia is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 A primary bacterial infectious disease that has material basis in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues.

CDC : 3 Tularemia takes many forms—Learn the symptoms

Wikipedia : 77 Tularemia, also known as rabbit fever, is an infectious disease caused by the bacterium Francisella... more...

Related Diseases for Tularemia

Diseases related to Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 pneumonic tularemia 34.0 STAB2 TLR2
2 ulceroglandular tularemia 33.2 CASP1 PDE6B STAB2
3 typhoid fever 29.9 CASP1 SLC11A1
4 bacterial infectious disease 29.7 CASP1 MBL2 SLC11A1 TLR2
5 legionellosis 29.3 CASP1 TLR2
6 oculoglandular tularemia 12.5
7 glandular tularemia 12.5
8 typhoidal tularemia 12.5
9 gastrointestinal tularemia 12.4
10 tick infestation 11.1
11 plague 10.5
12 pneumonia 10.4
13 lymphadenitis 10.4
14 cervical adenitis 10.3
15 anthrax disease 10.3
16 brucellosis 10.2
17 q fever 10.2
18 spotted fever 10.2
19 cytokine deficiency 10.2
20 rocky mountain spotted fever 10.2
21 leptospirosis 10.2
22 pasteurellosis 10.2 PDP1 STAB2
23 prosthetic joint infection 10.2 MBL2 TLR2
24 nontuberculous mycobacterial lung disease 10.2 SLC11A1 TLR2
25 vulvovaginal candidiasis 10.1 MBL2 TLR2
26 leprosy 3 10.1 SLC11A1 TLR2
27 neisseria meningitidis infection 10.1 MBL2 TLR2
28 invasive aspergillosis 10.1 MBL2 TLR2
29 testicular disease 10.1 SLC11A1 TLR2
30 pertussis 10.1
31 lyme disease 10.1
32 guillain-barre syndrome 10.1
33 pharyngitis 10.1
34 influenza 10.1
35 meningitis 10.1
36 bacterial vaginosis 10.1 MBL2 TLR2
37 extrapulmonary tuberculosis 10.0 P2RX7 SLC11A1 TLR2
38 epidemic typhus 10.0
39 variola major 10.0
40 lymphoma 10.0
41 endocarditis 10.0
42 tick paralysis 10.0
43 neuritis 10.0
44 smallpox 10.0
45 encephalitis 10.0
46 primary bacterial infectious disease 9.9 PDE6B SLC11A1 TLR2
47 pulmonary tuberculosis 9.9 MBL2 P2RX7 SLC11A1 TLR2
48 mycobacterium tuberculosis 1 9.9 MBL2 P2RX7 SLC11A1 TLR2
49 lymphoma, hodgkin, classic 9.8
50 psoriatic arthritis 9.8

Graphical network of the top 20 diseases related to Tularemia:



Diseases related to Tularemia

Symptoms & Phenotypes for Tularemia

MGI Mouse Phenotypes related to Tularemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 CASP1 MAN2B1 P2RX7 PDE6B PPARA STAB2
2 hematopoietic system MP:0005397 9.86 AIM2 CASP1 MAN2B1 MBL2 P2RX7 PDE6B
3 homeostasis/metabolism MP:0005376 9.81 AIM2 CASP1 MAN2B1 MBL2 P2RX7 PDE6B
4 immune system MP:0005387 9.56 AIM2 CASP1 MAN2B1 MBL2 P2RX7 PPARA
5 renal/urinary system MP:0005367 9.02 CASP1 MAN2B1 MBL2 STAB2 TLR2

Drugs & Therapeutics for Tularemia

Drugs for Tularemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2
2 Vaccines Phase 2
3
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Tularemia Vaccine Comparison Completed NCT01150695 Phase 2
2 Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Completed NCT00584844 Phase 2
3 Continued Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Enrolling by invitation NCT00787826 Phase 2
4 FY15-14: Tularemia Vaccine Protocol (NDBR Lot 4) Not yet recruiting NCT03867162 Phase 2
5 Fever After Tick Bite Study Recruiting NCT03932448

Search NIH Clinical Center for Tularemia

Genetic Tests for Tularemia

Anatomical Context for Tularemia

MalaCards organs/tissues related to Tularemia:

42
Skin, Lymph Node, Testes, T Cells, Neutrophil, Whole Blood, Tonsil

Publications for Tularemia

Articles related to Tularemia:

(show top 50) (show all 1024)
# Title Authors Year
1
Tularemia: an experience of 13 cases including a rare myocarditis in a referral center in Eastern Switzerland (Central Europe) and a review of the literature. ( 30656604 )
2019
2
Nanoparticle Formulation of Moxifloxacin and Intramuscular Route of Delivery Improve Antibiotic Pharmacokinetics and Treatment of Pneumonic Tularemia in a Mouse Model. ( 30480992 )
2019
3
Tularemia ( Francisella tularensis) in a Black-Tailed Prairie Dog ( Cynomys ludovicianus) Colony. ( 30920904 )
2019
4
Phylogenetic Analysis of Francisella tularensis Group A.II Isolates from 5 Patients with Tularemia, Arizona, USA, 2015-2017. ( 31002053 )
2019
5
Clinical characteristics in a sentinel case as well as in a cluster of tularemia patients associated with grape harvest. ( 31071480 )
2019
6
A case of ulceroglandular tularemia presenting with lymphadenopathy and an ulcer on a linear morphoea lesion surrounded by erysipelas. ( 30519119 )
2018
7
Tularemia-induced erythema multiforme minor in an 11-year-old girl. ( 29582465 )
2018
8
Glandular Tularemia. ( 30184456 )
2018
9
Simultaneous Immunodetection of Anthrax, Plague, and Tularemia from Blood Cultures by Use of Multiplexed Suspension Arrays. ( 29386263 )
2018
10
Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. ( 29725025 )
2018
11
Molecular Survey of Tularemia and Plague in Small Mammals From Iran. ( 30042927 )
2018
12
The Cynomolgus Macaque Natural History Model of Pneumonic Tularemia for Predicting Clinical Efficacy Under the Animal Rule. ( 29670861 )
2018
13
Tularemia in interepidemic period. ( 29054578 )
2018
14
Evaluation of In-House and Commercial Serological Tests for Diagnosis of Human Tularemia. ( 29118164 )
2018
15
Prevalence and Seasonality of Fleas Associated With California Ground Squirrels and the Potential Risk of Tularemia in an Outdoor Non-Human Primate Research Facility. ( 29202201 )
2018
16
Usefulness of a single-assay chemiluminescence test (Tularaemia VIRCLIA IgG + IgM monotest) for the diagnosis of human tularemia. Comparison of five serological tests. ( 29280085 )
2018
17
Re-emerging Tularemia in Some Middle East Countries: What Are the Reasons? ( 29445647 )
2018
18
Tularemia in Germany-A Re-emerging Zoonosis. ( 29503812 )
2018
19
Treatment-failure tularemia in children. ( 29563944 )
2018
20
Revisiting Francisella tularensis subsp. holarctica, Causative Agent of Tularemia in Germany With Bioinformatics: New Insights in Genome Structure, DNA Methylation and Comparative Phylogenetic Analysis. ( 29593661 )
2018
21
Population Genomics of Francisella tularensis subsp. holarctica and its Implication on the Eco-Epidemiology of Tularemia in Switzerland. ( 29623260 )
2018
22
A case of typhoidal tularemia in a male Japanese farmer. ( 29635071 )
2018
23
Difficulty in the Clinical Diagnosis of Tularemia: Highlighting the Importance of a Physical Exam. ( 29686920 )
2018
24
Human Dose-Response Data for Francisella tularensis and a Dose- and Time-Dependent Mathematical Model of Early-Phase Fever Associated with Tularemia After Inhalation Exposure. ( 29694682 )
2018
25
Case Report: Atypical Cutaneous Manifestations of Tularemia after Horsefly Bite. ( 29714156 )
2018
26
Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent F. tularensis subsp. tularensis. ( 29868510 )
2018
27
An Improved Tobacco Mosaic Virus (TMV)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia. ( 29922267 )
2018
28
Towards integrated surveillance of zoonoses: spatiotemporal joint modeling of rodent population data and human tularemia cases in Finland. ( 29976146 )
2018
29
Oropharyngeal Tularemia from Freshly Pressed Grape Must. ( 29996079 )
2018
30
Coinfections identified from metagenomic analysis of cervical lymph nodes from tularemia patients. ( 29996780 )
2018
31
Paenibacillus assamensis in Joint Fluid of Man with Suspected Tularemia, China. ( 30016244 )
2018
32
From Squirrels to Biological Weapons: The Early History of Tularemia. ( 30146078 )
2018
33
Tetracyclines for Treatment of Tularemia: A Case Series. ( 30191155 )
2018
34
Tularemia transmission to humans: a multifaceted surveillance approach. ( 30249311 )
2018
35
A case report of human tularemia from Iran. ( 30483377 )
2018
36
First Case of Tularemia Reported in Portugal: Probably of Imported Origin. ( 30510927 )
2018
37
Tularemia: diagnosis of an unexpected oculoglandular case in a non-endemic area by universal PCR. ( 30595228 )
2018
38
An O-Antigen Glycoconjugate Vaccine Produced Using Protein Glycan Coupling Technology Is Protective in an Inhalational Rat Model of Tularemia. ( 30622981 )
2018
39
Temporal Requirement for Pulmonary Resident and Circulating T Cells during Virulent Francisella tularensis Infection. ( 29980611 )
2018
40
A Novel Stochastic Multi-Scale Model of Francisella tularensis Infection to Predict Risk of Infection in a Laboratory. ( 30034369 )
2018
41
Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality. ( 30046592 )
2018
42
Early cellular responses of germ-free and specific-pathogen-free mice to Francisella tularensis infection. ( 30055244 )
2018
43
Severe glandular tularemia in a patient treated with anti-tumour necrosis factor for psoriatic arthritis. ( 28450199 )
2017
44
A Field Study of Plague and Tularemia in Rodents, Western Iran. ( 28165869 )
2017
45
The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4. ( 27939130 )
2017
46
Notes from the Field: Fatal Pneumonic Tularemia Associated with Dog Exposure - Arizona, June 2016. ( 28837551 )
2017
47
First case of severe pneumonic tularemia in an immunocompetent patient in the Netherlands. ( 28956784 )
2017
48
Protection of vaccinated mice against pneumonic tularemia is associated with an early memory sentinel-response in the lung. ( 29102170 )
2017
49
Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. ( 27630217 )
2017
50
High-risk regions and outbreak modelling of tularemia in humans. ( 27806741 )
2017

Variations for Tularemia

Expression for Tularemia

Search GEO for disease gene expression data for Tularemia.

Pathways for Tularemia

GO Terms for Tularemia

Cellular components related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 AIM2 inflammasome complex GO:0097169 8.62 AIM2 CASP1

Biological processes related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.58 MBL2 SLC11A1 STAB2
2 inflammatory response GO:0006954 9.56 AIM2 P2RX7 SLC11A1 TLR2
3 response to lipopolysaccharide GO:0032496 9.5 P2RX7 SLC11A1 TLR2
4 positive regulation of phagocytosis GO:0050766 9.37 MBL2 SLC11A1
5 positive regulation of interleukin-1 beta production GO:0032731 9.16 AIM2 P2RX7
6 positive regulation of interleukin-1 beta secretion GO:0050718 9.13 AIM2 CASP1 P2RX7
7 defense response to Gram-positive bacterium GO:0050830 8.92 MBL2 P2RX7 STAB2 TLR2

Molecular functions related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.13 P2RX7 PPARA TLR2
2 lipopolysaccharide binding GO:0001530 8.62 P2RX7 TLR2

Sources for Tularemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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