MCID: TLR001
MIFTS: 48

Tularemia

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Tularemia

MalaCards integrated aliases for Tularemia:

Name: Tularemia 12 76 53 59 3 15 73
Francisella Tularensis Infection 53
Pahvant Valley Plague 53
Deerfly Fever 53
Lemming Fever 53
Ohara Disease 53
Rabbit Fever 53
Yatobyo 53

Characteristics:

Orphanet epidemiological data:

59
tularemia
Prevalence: 1-9/1000000 (Europe),<1/1000000 (United Kingdom),<1/1000000 (Netherlands),1-9/100000 (Sweden),1-9/100000 (Czech Republic),1-9/100000 (Finland),1-9/1000000 (Austria),<1/1000000 (Belgium),<1/1000000 (Denmark),1-9/1000000 (Croatia),1-9/1000000 (Bulgaria),<1/1000000 (Estonia),<1/1000000 (France),<1/1000000 (Germany),<1/1000000 (Italy),1-9/1000000 (Latvia),<1/1000000 (Lithuania),<1/1000000 (Poland),<1/1000000 (Romania),<1/1000000 (Slovenia),1-9/1000000 (Switzerland),1-9/1000000 (Spain),1-9/100000 (Norway); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2123
ICD9CM 35 021.8
Orphanet 59 ORPHA3392
ICD10 via Orphanet 34 A21.0 A21.1 A21.2 more
MESH via Orphanet 45 D014406
UMLS via Orphanet 74 C0041351

Summaries for Tularemia

NIH Rare Diseases : 53 Tularemia is an infection caused by the bacterium Francisella tularensis. It is more common in rodents and rabbits but has been found in other animals including domestic cats, sheep, birds, and hamsters. Humans can become infected in several different ways: by handling infected animals, through tick or deer fly bites, by drinking contaminated water, or by inhaling contaminated dust or aerosols. Person-to-person transmission has not been reported. The type of tularemia and the particular signs and symptoms vary depending on how the bacteria enter the body. However, fever is seen in most cases. Though tularemia can be life-threatening, most infections can be treated with antibiotics.

MalaCards based summary : Tularemia, also known as francisella tularensis infection, is related to pneumonic tularemia and ulceroglandular tularemia. An important gene associated with Tularemia is SLC11A1 (Solute Carrier Family 11 Member 1), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and testes, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 A primary bacterial infectious disease that has material basis in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues.

CDC : 3 Tularemia is a disease of animals and humans caused by the bacterium Francisella tularensis. Rabbits, hares, and rodents are especially susceptible and often die in large numbers during outbreaks. Humans can become infected through several routes, including:

Wikipedia : 76 Tularemia, also known as rabbit fever, is an infectious disease caused by the bacterium Francisella... more...

Related Diseases for Tularemia

Diseases related to Tularemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 pneumonic tularemia 33.8 FTL STAB2 TLR2
2 ulceroglandular tularemia 33.3 CASP1 PDE6B STAB2
3 bacterial infectious disease 29.9 CASP1 MBL2 SLC11A1 TLR2
4 typhoid fever 29.8 CASP1 SLC11A1
5 legionellosis 29.4 CASP1 TLR2
6 oculoglandular tularemia 12.4
7 glandular tularemia 12.4
8 typhoidal tularemia 12.4
9 gastrointestinal tularemia 12.3
10 tick infestation 11.0
11 plague 10.4
12 pneumonia 10.4
13 lymphadenitis 10.4
14 cervical adenitis 10.2
15 brucellosis 10.2
16 q fever 10.2
17 spotted fever 10.2
18 rocky mountain spotted fever 10.2
19 leptospirosis 10.2
20 prosthetic joint infection 10.1 MBL2 TLR2
21 nontuberculous mycobacterial lung disease 10.1 SLC11A1 TLR2
22 vulvovaginal candidiasis 10.1 MBL2 TLR2
23 neisseria meningitidis infection 10.1 MBL2 TLR2
24 invasive aspergillosis 10.1 MBL2 TLR2
25 pasteurellosis 10.1 PDP1 STAB2
26 testicular disease 10.1 SLC11A1 TLR2
27 pertussis 10.1
28 pharyngitis 10.1
29 influenza 10.1
30 meningitis 10.1
31 bacterial vaginosis 10.1 MBL2 TLR2
32 lymphoma 10.0
33 endocarditis 10.0
34 tick paralysis 10.0
35 guillain-barre syndrome 10.0
36 neuritis 10.0
37 smallpox 10.0
38 encephalitis 10.0
39 extrapulmonary tuberculosis 10.0 MBL2 P2RX7 SLC11A1 TLR2
40 pulmonary tuberculosis 10.0 MBL2 P2RX7 SLC11A1 TLR2
41 mycobacterium tuberculosis 1 9.9 MBL2 P2RX7 SLC11A1 TLR2
42 primary bacterial infectious disease 9.9 PDE6B SLC11A1 TLR2
43 lymphoma, hodgkin, classic 9.8
44 psoriatic arthritis 9.8
45 myocardial infarction 9.8
46 legionnaire disease 9.8
47 graft-versus-host disease 9.8
48 acute myocardial infarction 9.8
49 adult respiratory distress syndrome 9.8
50 arthritis 9.8

Graphical network of the top 20 diseases related to Tularemia:



Diseases related to Tularemia

Symptoms & Phenotypes for Tularemia

MGI Mouse Phenotypes related to Tularemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 CASP1 MAN2B1 P2RX7 PDE6B PPARA STAB2
2 hematopoietic system MP:0005397 9.76 AIM2 CASP1 MAN2B1 MBL2 P2RX7 PDE6B
3 homeostasis/metabolism MP:0005376 9.61 AIM2 CASP1 MAN2B1 MBL2 P2RX7 PDE6B
4 immune system MP:0005387 9.23 AIM2 CASP1 MAN2B1 MBL2 P2RX7 PPARA

Drugs & Therapeutics for Tularemia

Drugs for Tularemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Tularemia Vaccine Comparison Completed NCT01150695 Phase 2
2 Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Completed NCT00584844 Phase 2
3 Continued Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine Enrolling by invitation NCT00787826 Phase 2

Search NIH Clinical Center for Tularemia

Genetic Tests for Tularemia

Anatomical Context for Tularemia

MalaCards organs/tissues related to Tularemia:

41
Skin, Lymph Node, Testes, T Cells, Lung, Neutrophil, Tonsil

Publications for Tularemia

Articles related to Tularemia:

(show top 50) (show all 1020)
# Title Authors Year
1
Human Dose-Response Data for Francisella tularensis and a Dose- and Time-Dependent Mathematical Model of Early-Phase Fever Associated with Tularemia After Inhalation Exposure. ( 29694682 )
2018
2
Re-emerging Tularemia in Some Middle East Countries: What Are the Reasons? ( 29445647 )
2018
3
Tularemia in interepidemic period. ( 29054578 )
2018
4
Towards integrated surveillance of zoonoses: spatiotemporal joint modeling of rodent population data and human tularemia cases in Finland. ( 29976146 )
2018
5
Evaluation of In-House and Commercial Serological Tests for Diagnosis of Human Tularemia. ( 29118164 )
2018
6
Case Report: Atypical Cutaneous Manifestations of Tularemia after Horsefly Bite. ( 29714156 )
2018
7
Tularemia-induced erythema multiforme minor in an 11-year-old girl. ( 29582465 )
2018
8
Simultaneous immunodetection of anthrax, plague and tularemia from blood cultures utilizing multiplexed suspension arrays. ( 29386263 )
2018
9
A case of typhoidal tularemia in a male Japanese farmer. ( 29635071 )
2018
10
An Improved Tobacco Mosaic Virus (TMV)-Conjugated Multiantigen Subunit Vaccine Against Respiratory Tularemia. ( 29922267 )
2018
11
Tularemia in Germany-A Re-emerging Zoonosis. ( 29503812 )
2018
12
Treatment-failure tularemia in children. ( 29563944 )
2018
13
Population Genomics of <i>Francisella tularensis</i> subsp. <i>holarctica</i> and its Implication on the Eco-Epidemiology of Tularemia in Switzerland. ( 29623260 )
2018
14
Revisiting <i>Francisella tularensis</i> subsp. <i>holarctica</i>, Causative Agent of Tularemia in Germany With Bioinformatics: New Insights in Genome Structure, DNA Methylation and Comparative Phylogenetic Analysis. ( 29593661 )
2018
15
Single vector platform vaccine protects against lethal respiratory challenge with Tier 1 select agents of anthrax, plague, and tularemia. ( 29725025 )
2018
16
Live Attenuated Tularemia Vaccines for Protection Against Respiratory Challenge With Virulent <i>F. tularensis</i> subsp. <i>tularensis</i>. ( 29868510 )
2018
17
The Cynomolgus Macaque Natural History Model of Pneumonic Tularemia for Predicting Clinical Efficacy Under the Animal Rule. ( 29670861 )
2018
18
Difficulty in the Clinical Diagnosis of Tularemia: Highlighting the Importance of a Physical Exam. ( 29686920 )
2018
19
A case of ulceroglandular tularemia presenting with lymphadenopathy and an ulcer on a linear morphoea lesion surrounded by erysipelas. ( 30519119 )
2018
20
Glandular Tularemia. ( 30184456 )
2018
21
Molecular Survey of Tularemia and Plague in Small Mammals From Iran. ( 30042927 )
2018
22
Nanoparticle formulation of moxifloxacin and intramuscular route of delivery improve antibiotic pharmacokinetics and treatment of pneumonic tularemia in a mouse model. ( 30480992 )
2018
23
Oropharyngeal Tularemia from Freshly Pressed Grape Must. ( 29996079 )
2018
24
Coinfections identified from metagenomic analysis of cervical lymph nodes from tularemia patients. ( 29996780 )
2018
25
Paenibacillus assamensis in Joint Fluid of Man with Suspected Tularemia, China. ( 30016244 )
2018
26
From Squirrels to Biological Weapons: The Early History of Tularemia. ( 30146078 )
2018
27
Tetracyclines for Treatment of Tularemia: A Case Series. ( 30191155 )
2018
28
Tularemia transmission to humans: a multifaceted surveillance approach. ( 30249311 )
2018
29
A case report of human tularemia from Iran. ( 30483377 )
2018
30
First Case of Tularemia Reported in Portugal: Probably of Imported Origin. ( 30510927 )
2018
31
Temporal Requirement for Pulmonary Resident and Circulating T Cells during Virulent Francisella tularensis Infection. ( 29980611 )
2018
32
A Novel Stochastic Multi-Scale Model of Francisella tularensis Infection to Predict Risk of Infection in a Laboratory. ( 30034369 )
2018
33
Obesity Exacerbates the Cytokine Storm Elicited by Francisella tularensis Infection of Females and Is Associated with Increased Mortality. ( 30046592 )
2018
34
Early cellular responses of germ-free and specific-pathogen-free mice to Francisella tularensis infection. ( 30055244 )
2018
35
Rare Cause of Pleuropnemonia: Tularemia Disease. ( 29017676 )
2017
36
Clinical Characteristics of Ulceroglandular Tularemia in Two Bulgarian Regions, 2014-2015: a Report of Five Cases. ( 29341950 )
2017
37
A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia. ( 28328947 )
2017
38
Human Cases of Tularemia in Armenia, 1996-2012. ( 28722639 )
2017
39
Irruptive mammal host populations shape tularemia epidemiology. ( 29145508 )
2017
40
Atypical Presentations of Tularemia. ( 28813752 )
2017
41
Prevalence and Seasonality of Fleas Associated With California Ground Squirrels and the Potential Risk of Tularemia in an Outdoor Non-Human Primate Research Facility. ( 29202201 )
2017
42
High-risk regions and outbreak modelling of tularemia in humans. ( 27806741 )
2017
43
First case of severe pneumonic tularemia in an immunocompetent patient in the Netherlands. ( 28956784 )
2017
44
Protection of vaccinated mice against pneumonic tularemia is associated with an early memory sentinel-response in the lung. ( 29102170 )
2017
45
Notes from the Field: Fatal Pneumonic Tularemia Associated with Dog Exposure - Arizona, June 2016. ( 28837551 )
2017
46
A Field Study of Plague and Tularemia in Rodents, Western Iran. ( 28165869 )
2017
47
The Natural History of Pneumonic Tularemia in Female Fischer 344 Rats after Inhalational Exposure to Aerosolized Francisella tularensis Subspecies tularensis Strain SCHU S4. ( 27939130 )
2017
48
Tularemia vaccine: Safety, reactogenicity, &amp;quot;Take&amp;quot; skin reactions, and antibody responses following vaccination with a new lot of the Francisella tularensis live vaccine strain - A phase 2 randomized clinical Trial. ( 28750854 )
2017
49
Imaging Findings of Ulceroglandular Tularemia. ( 28580063 )
2017
50
Expansion and retention of pulmonary CD4(+) T cells after prime boost vaccination correlates with improved longevity and strength of immunity against tularemia. ( 28372827 )
2017

Variations for Tularemia

Expression for Tularemia

Search GEO for disease gene expression data for Tularemia.

Pathways for Tularemia

GO Terms for Tularemia

Cellular components related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 AIM2 inflammasome complex GO:0097169 8.62 AIM2 CASP1

Biological processes related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.71 FTL MAN2B1 SLC11A1 TLR2
2 defense response to bacterium GO:0042742 9.65 MBL2 SLC11A1 STAB2
3 inflammatory response GO:0006954 9.56 AIM2 P2RX7 SLC11A1 TLR2
4 response to lipopolysaccharide GO:0032496 9.54 P2RX7 SLC11A1 TLR2
5 positive regulation of phagocytosis GO:0050766 9.46 MBL2 SLC11A1
6 iron ion homeostasis GO:0055072 9.43 FTL SLC11A1
7 iron ion transport GO:0006826 9.32 FTL SLC11A1
8 positive regulation of interleukin-1 beta production GO:0032731 9.16 AIM2 P2RX7
9 positive regulation of interleukin-1 beta secretion GO:0050718 9.13 AIM2 CASP1 P2RX7
10 defense response to Gram-positive bacterium GO:0050830 8.92 MBL2 P2RX7 STAB2 TLR2

Molecular functions related to Tularemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.13 P2RX7 PPARA TLR2
2 lipopolysaccharide binding GO:0001530 8.62 P2RX7 TLR2

Sources for Tularemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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