MCID: TMR001
MIFTS: 25

Tumor of Exocrine Pancreas

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Tumor of Exocrine Pancreas

MalaCards integrated aliases for Tumor of Exocrine Pancreas:

Name: Tumor of Exocrine Pancreas 12 15 74
Malignant Neoplasm of the Exocrine Pancreas 12
Malignant Tumor of Exocrine Pancreas 12
Pancreatic Exocrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1795
NCIt 51 C4445 C7430

Summaries for Tumor of Exocrine Pancreas

MalaCards based summary : Tumor of Exocrine Pancreas, also known as malignant neoplasm of the exocrine pancreas, is related to solid adenocarcinoma with mucin production and chronic ethmoiditis. An important gene associated with Tumor of Exocrine Pancreas is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways is Diseases of glycosylation. The drugs Gemcitabine and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include pancreas.

Related Diseases for Tumor of Exocrine Pancreas

Diseases related to Tumor of Exocrine Pancreas via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 solid adenocarcinoma with mucin production 10.1 MUC1 MUC6
2 chronic ethmoiditis 10.1 MUC1 MUC6
3 microcystic adenoma 10.1 MUC1 MUC6
4 bile duct cystadenocarcinoma 10.1 MUC1 MUC6
5 appendix disease 10.1 GNAS MUC6
6 adenomyoma 10.1 MUC1 MUC6
7 mucinous tubular and spindle renal cell carcinoma 10.1 MUC1 MUC6
8 biliary papillomatosis 10.1 MUC1 MUC6
9 ethmoid sinusitis 10.1 MUC1 MUC6
10 duodenum cancer 10.1 MUC1 MUC6
11 pseudomyxoma peritonei 10.1 MUC1 MUC6
12 gastric tubular adenocarcinoma 10.1 MUC1 MUC6
13 mixed ductal-endocrine carcinoma 10.1 MUC1 MUC6
14 signet ring cell adenocarcinoma 10.1 MUC1 MUC6
15 ampulla of vater cancer 10.1 MUC1 MUC6
16 pancreatic ductal carcinoma 10.1 MUC1 MUC6
17 villous adenoma 10.1 GNAS MUC1
18 cystadenoma 10.0 MUC1 MUC6
19 colorectal cancer 1 10.0 MUC1 MUC6
20 osteofibrous dysplasia 10.0 GNAS MUC1
21 cholecystitis 10.0 MUC1 MUC6
22 sinonasal undifferentiated carcinoma 9.9 MKI67 MUC1
23 endometrial mucinous adenocarcinoma 9.9 MKI67 MUC1
24 polymorphous low-grade adenocarcinoma 9.9 MKI67 MUC1
25 appendix cancer 9.8 GNAS MUC1 MUC6
26 malignant fibroxanthoma 9.8 MKI67 MUC1
27 meningioma, radiation-induced 9.8 MKI67 MUC1
28 endocrine gland cancer 9.8 GNAS MUC1
29 cavernous hemangioma 9.8 MKI67 MUC1
30 ependymoma 9.7 MKI67 MUC1
31 ductal carcinoma in situ 9.7 MKI67 MUC1
32 large intestine cancer 9.7 GNAS MUC1 RNF43
33 mucoepidermoid carcinoma 9.7 MKI67 MUC1
34 barrett esophagus 9.6 MKI67 MUC6
35 pancreatic intraductal papillary-mucinous neoplasm 9.5 GNAS MUC1 MUC6 RNF43
36 pancreas adenocarcinoma 9.5 GNAS MUC1 MUC6 RNF43

Graphical network of the top 20 diseases related to Tumor of Exocrine Pancreas:



Diseases related to Tumor of Exocrine Pancreas

Symptoms & Phenotypes for Tumor of Exocrine Pancreas

Drugs & Therapeutics for Tumor of Exocrine Pancreas

Drugs for Tumor of Exocrine Pancreas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
2
Capecitabine Approved, Investigational Phase 1, Phase 2 154361-50-9 60953
3
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 6857599 5310940 9887054 43805
4 Antimetabolites Phase 2,Phase 1
5 Anti-Infective Agents Phase 2,Phase 1
6 Immunologic Factors Phase 2,Phase 1
7 Antimetabolites, Antineoplastic Phase 2,Phase 1
8 Immunosuppressive Agents Phase 2,Phase 1
9 Antiviral Agents Phase 2,Phase 1
10
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
11 Albumin-Bound Paclitaxel Phase 1
12 Antimitotic Agents Phase 1
13 Pharmaceutical Solutions Phase 1
14 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Safety and Tolerability of PCI-27483 in Patients With Pancreatic Cancer Patients Receiving Treatment With Gemcitabine Completed NCT01020006 Phase 2 PCI-27483;Gemcitabine
2 Gemcitabine, Oxaliplatin and Capecitabine in Patients With Advanced Cholangiocarcinoma Completed NCT00350961 Phase 1, Phase 2 Gemcitabine;Oxaliplatin;Capecitabine
3 Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors Recruiting NCT03485209 Phase 2 tisotumab vedotin
4 CEND-1 in Combination With Nabpaclitaxel and Gemcitabine in Metastatic Pancreatic Cancer Recruiting NCT03517176 Phase 1 CEND-1;Nab-paclitaxel;Gemcitabine
5 Evaluation of Survival Prognostic Factors for Patients With Exocrine Pancreatic Cancer Resectable or Potentially Resectable Recruiting NCT02818907 Not Applicable
6 Distal Pancreatectomy With Partial Splenectomy for Pancreatic Tumors Withdrawn NCT01412684

Search NIH Clinical Center for Tumor of Exocrine Pancreas

Genetic Tests for Tumor of Exocrine Pancreas

Anatomical Context for Tumor of Exocrine Pancreas

MalaCards organs/tissues related to Tumor of Exocrine Pancreas:

42
Pancreas

Publications for Tumor of Exocrine Pancreas

Variations for Tumor of Exocrine Pancreas

Expression for Tumor of Exocrine Pancreas

Search GEO for disease gene expression data for Tumor of Exocrine Pancreas.

Pathways for Tumor of Exocrine Pancreas

Pathways related to Tumor of Exocrine Pancreas according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.79 MUC1 MUC6

GO Terms for Tumor of Exocrine Pancreas

Cellular components related to Tumor of Exocrine Pancreas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.62 MUC1 MUC6

Biological processes related to Tumor of Exocrine Pancreas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.96 MUC1 MUC6
2 O-glycan processing GO:0016266 8.62 MUC1 MUC6

Sources for Tumor of Exocrine Pancreas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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