MCID: TMR001
MIFTS: 30

Tumor of Exocrine Pancreas

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Tumor of Exocrine Pancreas

MalaCards integrated aliases for Tumor of Exocrine Pancreas:

Name: Tumor of Exocrine Pancreas 12 15 71
Malignant Neoplasm of the Exocrine Pancreas 12
Malignant Tumour of Exocrine Pancreas 12
Malignant Tumor of Exocrine Pancreas 12
Tumour of Exocrine Pancreas 12
Pancreatic Exocrine Tumour 12
Pancreatic Exocrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1795
NCIt 49 C4445 C7430
SNOMED-CT 67 254604005 255088001
UMLS 71 C0345920 C0346648

Summaries for Tumor of Exocrine Pancreas

MalaCards based summary : Tumor of Exocrine Pancreas, also known as malignant neoplasm of the exocrine pancreas, is related to pancreatic cancer and gastric tubular adenocarcinoma. An important gene associated with Tumor of Exocrine Pancreas is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Metabolism of proteins and Toll-like Receptor Signaling Pathway. Affiliated tissues include pancreas, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Tumor of Exocrine Pancreas

Diseases related to Tumor of Exocrine Pancreas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 319)
# Related Disease Score Top Affiliating Genes
1 pancreatic cancer 26.9 TP53 SMAD4 MUC6 MUC5AC MUC1 KRAS
2 gastric tubular adenocarcinoma 10.5 MUC6 MUC5AC
3 cobblestone retinal degeneration 10.4 KRAS HRAS
4 ampulla of vater neoplasm 10.4 KRAS HRAS
5 periampullary adenoma 10.4 KRAS HRAS
6 colloid carcinoma of the pancreas 10.4 MUC5AC MUC1
7 adenosquamous lung carcinoma 10.4 KRAS HRAS
8 acneiform dermatitis 10.4 KRAS HRAS
9 gastritis, familial giant hypertrophic 10.4 MUC6 MUC5AC
10 myh-associated polyposis 10.4 KRAS HRAS
11 mucinous lung adenocarcinoma 10.4 KRAS HRAS
12 anal gland adenocarcinoma 10.4 MUC5AC CDX2
13 anal canal adenocarcinoma 10.4 MUC5AC CDX2
14 pancreatic acinar cell adenocarcinoma 10.4 KRAS HRAS
15 mucinous tubular and spindle renal cell carcinoma 10.4 MUC6 MUC1
16 syringocystadenoma papilliferum 10.3 MUC1 KRAS
17 filamentary keratitis 10.3 MUC5AC MUC1
18 limbal stem cell deficiency 10.3 MUC5AC MUC1
19 core binding factor acute myeloid leukemia 10.3 KRAS HRAS
20 lung carcinoma in situ 10.3 KRAS HRAS
21 colorectal cancer, hereditary nonpolyposis, type 8 10.3 MUC5AC MUC1
22 paronychia 10.3 KRAS HRAS
23 pulmonary adenocarcinoma in situ 10.3 KRAS HRAS
24 chronic ethmoiditis 10.3 MUC6 MUC5AC MUC1
25 solid adenocarcinoma with mucin production 10.3 MUC6 MUC5AC MUC1
26 complete androgen insensitivity syndrome 10.3 MUC5AC MUC1
27 schimmelpenning-feuerstein-mims syndrome 10.3 KRAS HRAS GNAS
28 colorectal cancer 1 10.3 MUC6 MUC5AC MUC1
29 nevus, epidermal 10.3 KRAS HRAS GNAS
30 intrahepatic biliary papillomatosis 10.2 MUC5AC MUC1 KRAS
31 malignant peritoneal mesothelioma 10.2 MUC1 CDKN2A
32 pancreatic serous cystadenoma 10.2 MUC6 CEACAM5
33 endometrial mucinous adenocarcinoma 10.2 MUC1 CDKN2A
34 anal canal paget's disease 10.2 CDX2 CDKN2A
35 nasal cavity adenocarcinoma 10.2 KRAS HRAS CDX2
36 calcinosis 10.2 MUC5AC MUC1 GNAS
37 eccrine porocarcinoma 10.2 MUC1 CEACAM5
38 oculoectodermal syndrome 10.2 KRAS HRAS
39 immature teratoma of ovary 10.2 KRAS CEACAM5
40 sigmoid neoplasm 10.2 KRAS CEACAM5
41 bile acid synthesis defect, congenital, 5 10.2 KRAS CEACAM5
42 plasmablastic lymphoma 10.2 MUC1 CDKN2A
43 ampulla of vater adenocarcinoma 10.2 MUC5AC MUC1 CDX2
44 nodular hidradenoma 10.1 MUC1 CEACAM5
45 lipid-rich breast carcinoma 10.1 MUC1 CEACAM5
46 anal paget's disease 10.1 CEACAM5 CDX2
47 ureter adenocarcinoma 10.1 CEACAM5 CDX2
48 laryngeal mucoepidermoid carcinoma 10.1 CEACAM5 CDX2
49 epstein-barr virus-associated gastric carcinoma 10.1 MUC6 MUC5AC CDKN2A
50 mucinous adenofibroma 10.1 CEACAM5 CDX2

Graphical network of the top 20 diseases related to Tumor of Exocrine Pancreas:



Diseases related to Tumor of Exocrine Pancreas

Symptoms & Phenotypes for Tumor of Exocrine Pancreas

MGI Mouse Phenotypes related to Tumor of Exocrine Pancreas:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 A4GNT CDKN2A CDX2 HRAS KRAS MUC5AC
2 endocrine/exocrine gland MP:0005379 9.76 CDKN2A CDX2 GNAS HRAS KRAS RNF43
3 neoplasm MP:0002006 9.61 A4GNT CDKN2A CDX2 GNAS HRAS KRAS
4 normal MP:0002873 9.17 CDX2 GNAS HRAS KRAS RBM10 SMAD4

Drugs & Therapeutics for Tumor of Exocrine Pancreas

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study of Distal Pancreatectomy With Partial Splenectomy for Pancreatic Tumors Arising in the Body and Tail of the Pancreas Withdrawn NCT01412684

Search NIH Clinical Center for Tumor of Exocrine Pancreas

Genetic Tests for Tumor of Exocrine Pancreas

Anatomical Context for Tumor of Exocrine Pancreas

MalaCards organs/tissues related to Tumor of Exocrine Pancreas:

40
Pancreas

Publications for Tumor of Exocrine Pancreas

Articles related to Tumor of Exocrine Pancreas:

# Title Authors PMID Year
1
Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement: Two case reports and literature review. 61
28930825 2017

Variations for Tumor of Exocrine Pancreas

Expression for Tumor of Exocrine Pancreas

Search GEO for disease gene expression data for Tumor of Exocrine Pancreas.

Pathways for Tumor of Exocrine Pancreas

Pathways related to Tumor of Exocrine Pancreas according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 TP53 SMAD4 MUC6 MUC5AC MUC1 CEACAM5
2
Show member pathways
12.94 TP53 SMAD4 KRAS HRAS GNAS
3
Show member pathways
12.79 TP53 KRAS HRAS GNAS CDKN2A
4
Show member pathways
12.74 TP53 SMAD4 KRAS HRAS CDKN2A
5 12.57 TP53 SMAD4 KRAS HRAS GNAS CDKN2A
6
Show member pathways
12.52 TP53 KRAS HRAS GNAS CDKN2A
7 12.4 TP53 KRAS HRAS CDKN2A
8
Show member pathways
12.4 TP53 SMAD4 KRAS HRAS CDX2 CDKN2A
9
Show member pathways
12.32 TP53 SMAD4 MUC1 KRAS HRAS
10 12.17 TP53 KRAS HRAS CDKN2A
11
Show member pathways
12.13 MUC6 MUC5AC MUC1 KRAS HRAS
12
Show member pathways
12.11 MUC6 MUC5AC MUC1 A4GNT
13 12.05 TP53 SMAD4 KRAS GNAS
14 11.99 TP53 KRAS HRAS CDKN2A
15
Show member pathways
11.97 SMAD4 KRAS HRAS
16 11.97 SMAD4 KRAS HRAS
17 11.91 TP53 KRAS HRAS
18 11.89 TP53 KRAS HRAS
19 11.89 TP53 SMAD4 KRAS HRAS CDKN2A
20 11.87 KRAS HRAS GNAS
21
Show member pathways
11.85 KRAS HRAS GNAS
22
Show member pathways
11.84 MUC6 MUC5AC MUC1
23 11.79 SMAD4 KRAS HRAS
24 11.78 TP53 KRAS HRAS CDKN2A
25 11.73 KRAS HRAS GNAS
26 11.73 TP53 SMAD4 HRAS CDKN2A
27 11.61 TP53 KRAS HRAS
28 11.58 TP53 KRAS HRAS
29 11.52 KRAS HRAS GNAS
30 11.13 SMAD4 KRAS HRAS
31 11.12 TP53 KRAS HRAS CDKN2A
32 11.08 TP53 SMAD4 KRAS HRAS CDKN2A
33 10.96 KRAS HRAS
34 10.74 KRAS HRAS

GO Terms for Tumor of Exocrine Pancreas

Cellular components related to Tumor of Exocrine Pancreas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC6 MUC5AC MUC1

Biological processes related to Tumor of Exocrine Pancreas according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.67 TP53 HRAS CDKN2A
2 negative regulation of cell growth GO:0030308 9.65 TP53 SMAD4 CDKN2A
3 negative regulation of cell proliferation GO:0008285 9.65 TP53 SMAD4 RBM10 HRAS CDKN2A
4 positive regulation of cellular senescence GO:2000774 9.51 KRAS CDKN2A
5 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.46 TP53 MUC1
6 Ras protein signal transduction GO:0007265 9.46 TP53 KRAS HRAS CDKN2A
7 replicative senescence GO:0090399 9.43 TP53 CDKN2A
8 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.4 RBM10 CDKN2A
9 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.37 TP53 MUC1
10 response to isolation stress GO:0035900 9.32 KRAS HRAS
11 O-glycan processing GO:0016266 9.26 MUC6 MUC5AC MUC1 A4GNT
12 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 MUC6 MUC5AC MUC1 KRAS HRAS

Sources for Tumor of Exocrine Pancreas

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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