MCID: TNG001
MIFTS: 39

Tungiasis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Tungiasis

MalaCards integrated aliases for Tungiasis:

Name: Tungiasis 12 76 53 59 15
Tunga Penetrans Infestation 73
Sarcopsylla Penetrans 53
Tunga Penetrans 53
Chigger Flea 53
S Penetrans 53
T Penetrans 53

Characteristics:

Orphanet epidemiological data:

59
tungiasis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050266
Orphanet 59 ORPHA879
UMLS via Orphanet 74 C0277356
MESH via Orphanet 45 D058285
ICD10 via Orphanet 34 B88.1
ICD10 33 B88.1
UMLS 73 C0277356

Summaries for Tungiasis

Disease Ontology : 12 A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

MalaCards based summary : Tungiasis, also known as tunga penetrans infestation, is related to scabies and trichuriasis. An important gene associated with Tungiasis is NDUFS3 (NADH:Ubiquinone Oxidoreductase Core Subunit S3), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. Affiliated tissues include skin.

Wikipedia : 76 Tungiasis (also known as nigua,pio and bicho de pie, or pique or sand flea disease) is an inflammatory... more...

Related Diseases for Tungiasis

Diseases related to Tungiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
# Related Disease Score Top Affiliating Genes
1 scabies 29.5 CXCL8 IL10
2 trichuriasis 28.7 CXCL8 IL10 TNF
3 skin disease 28.1 CXCL8 IL10 IL4 TNF
4 malaria 27.8 CXCL8 IL10 IL4 TNF
5 scleritis 10.4 IL4 TNF
6 microscopic colitis 10.4 IL4 TNF
7 commensal bacterial infectious disease 10.4 DPT TNF
8 lichen disease 10.3 IL4 TNF
9 rasmussen encephalitis 10.3 IL4 TNF
10 papillary conjunctivitis 10.3 CXCL8 IL4
11 giant papillary conjunctivitis 10.3 CXCL8 IL4
12 opisthorchiasis 10.3 CXCL8 IL4
13 streptococcal toxic-shock syndrome 10.2 CXCL8 TNF
14 haemophilus influenzae 10.2 CXCL8 TNF
15 crohn's colitis 10.2 CXCL8 TNF
16 leukocyte disease 10.2 IL4 TNF
17 meconium aspiration syndrome 10.2 CXCL8 TNF
18 mycobacterium abscessus 10.2 CXCL8 TNF
19 louse-borne relapsing fever 10.2 CXCL8 TNF
20 dental pulp disease 10.2 CXCL8 TNF
21 neuritis 10.1 IL4 TNF
22 pleural tuberculosis 10.1 CXCL8 TNF
23 tuberculous meningitis 10.1 CXCL8 TNF
24 pulpitis 10.1 CXCL8 TNF
25 allergic conjunctivitis 10.1 CXCL8 IL4
26 middle ear disease 10.1 CXCL8 TNF
27 pyoderma gangrenosum 10.1 CXCL8 TNF
28 pyoderma 10.1 CXCL8 TNF
29 perinatal necrotizing enterocolitis 10.1 CXCL8 TNF
30 fasciitis 10.1 CXCL8 TNF
31 interstitial cystitis 10.1 CXCL8 IL4
32 pleurisy 10.1 CXCL8 TNF
33 hyperlucent lung 10.1 IL10 IL4
34 uterine anomalies 10.1 CXCL8 TNF
35 cutaneous larva migrans 10.1
36 immunoglobulin a deficiency 1 10.1 IL10 IL4
37 acute respiratory distress syndrome 10.0 CXCL8 TNF
38 bacterial vaginosis 10.0 CXCL8 TNF
39 retinitis pigmentosa 22 10.0 IL10 IL4
40 baylisascariasis 10.0 IL10 IL4
41 apple allergy 10.0 IL10 IL4
42 beta-lactam allergy 10.0 IL10 IL4
43 buruli ulcer 10.0 IL10 IL4
44 punctate inner choroidopathy 10.0 IL10 TNF
45 bardet-biedl syndrome 15 10.0 IL10 IL4
46 genital herpes 10.0 IL10 IL4
47 avian influenza 10.0 CXCL8 TNF
48 microscopic polyangiitis 10.0 IL10 TNF
49 multifocal choroiditis 10.0 IL10 TNF
50 transient hypogammaglobulinemia 10.0 IL10 TNF

Graphical network of the top 20 diseases related to Tungiasis:



Diseases related to Tungiasis

Symptoms & Phenotypes for Tungiasis

Drugs & Therapeutics for Tungiasis

Search Clinical Trials , NIH Clinical Center for Tungiasis

Genetic Tests for Tungiasis

Anatomical Context for Tungiasis

MalaCards organs/tissues related to Tungiasis:

41
Skin

Publications for Tungiasis

Articles related to Tungiasis:

(show top 50) (show all 150)
# Title Authors Year
1
Dermoscopic Features of Tungiasis. ( 29430724 )
2018
2
Tungiasis Presenting as Onychomycosis: Probably the First Report of Flea Infestation of the Nail Observed Using Modified Potassium Hydroxide Mount Technique. ( 29736361 )
2018
3
Animal and human tungiasis-related knowledge and treatment practices among animal keeping households in Bugiri District, South-Eastern Uganda. ( 29017876 )
2018
4
Cutaneous larva migrans and tungiasis: infestations of the affluent society. ( 29417800 )
2018
5
Tungiasis-related life quality impairment in children living in rural Kenya. ( 29309411 )
2018
6
Tungiasis: A Rare Parasitic Infestation in Genitals of a Native Male from Kathmandu. ( 29353907 )
2018
7
Tungiasis in a Colombian patient. ( 28286017 )
2017
8
The prevalence and association with health-related quality of life of tungiasis and scabies in schoolchildren in southern Ethiopia. ( 28771469 )
2017
9
Treatment of tungiasis with a two-component dimeticone: a comparison between moistening the whole foot and directly targeting the embedded sand fleas. ( 28293130 )
2017
10
Disseminated tungiasis. ( 29166519 )
2017
11
Not a simple plantar wart: A case of tungiasis. ( 28924985 )
2017
12
Prevalence, intensity and risk factors of tungiasis in Kilifi County, Kenya: I. Results from a community-based study. ( 28991909 )
2017
13
Tungiasis: a poorly-known diagnosis in Europe. Two paradigmatic cases from Portugal. ( 29264904 )
2017
14
Tungiasis: Outbreak investigation of a zoonosis during overseas deployment. ( 29386713 )
2017
15
High-resolution infrared thermography: a new tool to assess tungiasis-associated inflammation of the skin. ( 28919835 )
2017
16
Secondary bacterial infections and antibiotic resistance among tungiasis patients in Western, Kenya. ( 28886013 )
2017
17
Canine tungiasis: High prevalence in a tourist region in Bahia state, Brazil. ( 28364835 )
2017
18
Tungiasis-associated morbidity in pigs and dogs in endemic villages of Uganda. ( 26817587 )
2016
19
Tungiasis: diagnosis at a glance. ( 26880125 )
2016
20
Tungiasis in Italy: An imported case of Tunga penetrans and review of the literature. ( 26876782 )
2016
21
Successful Treatment of Severe Tungiasis in Pigs Using a Topical Aerosol Containing Chlorfenvinphos, Dichlorphos and Gentian Violet. ( 27727268 )
2016
22
Two Severe Cases of Tungiasis in Goat Kids in Uganda. ( 27012871 )
2016
23
Disseminated tungiasis in a 78-year-old woman from Tanzania: a case report. ( 27998311 )
2016
24
Prevalence and clinical aspects of tungiasis in south-west Nigerian schoolchildren. ( 27402650 )
2016
25
Bullous tungiasis. ( 27068598 )
2016
26
Prevalence and risk factors associated with tungiasis in Mayuge district, Eastern Uganda. ( 27642416 )
2016
27
Animal Reservoirs of Zoonotic Tungiasis in Endemic Rural Villages of Uganda. ( 26473360 )
2015
28
Tungiasis: A Neglected Disease Related to Poverty. ( 26861421 )
2015
29
Tungiasis Outbreak in Travelers From Madagascar. ( 26031478 )
2015
30
Dermoscopy in tungiasis. ( 25035378 )
2014
31
Tungiasis: "the greatest curse that has ever afflicted Africa". ( 25007105 )
2014
32
Tungiasis-a neglected disease with many challenges for global public health. ( 25356978 )
2014
33
Tungiasis in Haiti: a case series of 383 patients. ( 24601858 )
2014
34
Treatment of Tungiasis with dimeticone: a proof-of-principle study in rural Kenya. ( 25079375 )
2014
35
Tungiasis in Northern Tanzania: a clinical report from Qameyu village, Babati District, Manyara Region. ( 25390058 )
2014
36
Tungiasis presenting as a soft tissue oral lesion. ( 25186303 )
2014
37
Tungiasis under dermoscopy: in vivo and ex vivo examination of the cutaneous infestation due to Tunga penetrans. ( 24068146 )
2013
38
Histopathological features of tungiasis in Peru. ( 23478579 )
2013
39
Regression of severe tungiasis-associated morbidity after prevention of re-infestation: a case series from rural Madagascar. ( 24043689 )
2013
40
Prevention of tungiasis and tungiasis-associated morbidity using the plant-based repellent Zanzarin: a randomized, controlled field study in rural Madagascar. ( 24069481 )
2013
41
Tungiasis - A Janus-faced parasitic skin disease. ( 24211240 )
2013
42
Two Cases of Imported Tungiasis with Severe Superinfection. ( 24352215 )
2013
43
A hemorrhagic-crusted papule with a central crater on the heel. Tungiasis. ( 23986152 )
2013
44
Tungiasis (sand flea disease): a parasitic disease with particular challenges for public health. ( 22941398 )
2013
45
Tungiasis: a neglected epidermal parasitic skin disease of marginalized populations--a call for global science and policy. ( 23949241 )
2013
46
Jigger flea infestation (tungiasis) in rural western Tanzania: high prevalence and severe morbidity. ( 22305586 )
2012
47
Outbreak of tungiasis following a trip to Ethiopia. ( 23031181 )
2012
48
A patient returning from Africa finds a mass imbedded in the skin of her right foot. Tungiasis. ( 23045600 )
2012
49
Tungiasis in a free-ranging jaguar (Panthera onca) population in Brazil. ( 21863398 )
2012
50
Dermoscopy: Ex vivo visualization of fleas head and bag of eggs confirms the diagnosis of Tungiasis. ( 22571560 )
2012

Variations for Tungiasis

Expression for Tungiasis

Search GEO for disease gene expression data for Tungiasis.

Pathways for Tungiasis

Pathways related to Tungiasis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 CXCL8 IL10 IL4 TNF
2 12.32 IL10 IL4 TNF
3
Show member pathways
12.26 CXCL8 IL10 IL4 TNF
4
Show member pathways
12.21 IL10 IL4 TNF
5
Show member pathways
12.19 IL10 IL4 TNF
6
Show member pathways
12.09 CXCL8 IL4 TNF
7
Show member pathways
12.02 IL10 IL4 TNF
8
Show member pathways
11.93 CXCL8 IL4 TNF
9 11.91 CXCL8 IL10 TNF
10
Show member pathways
11.83 CXCL8 IL10 IL4
11 11.77 CXCL8 IL4 TNF
12 11.74 IL10 IL4 TNF
13 11.64 CXCL8 IL10 TNF
14 11.54 IL10 IL4 TNF
15
Show member pathways
11.49 CXCL8 IL4 TNF
16 11.46 CXCL8 IL10 TNF
17 11.38 CXCL8 TNF
18 11.31 CXCL8 IL10 IL4 TNF
19 11.3 CXCL8 IL4 TNF
20 11.29 IL10 IL4
21 11.17 IL10 TNF
22 11.16 IL10 TNF
23 11.12 CXCL8 IL10 TNF
24 11.1 IL4 TNF
25 11.01 IL10 IL4
26 10.96 CXCL8 TNF
27 10.83 CXCL8 TNF
28 10.81 IL10 IL4 TNF
29 10.61 CXCL8 IL10 IL4 TNF

GO Terms for Tungiasis

Cellular components related to Tungiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CXCL8 DPT IL10 IL4 TNF

Biological processes related to Tungiasis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.78 CXCL8 IL10 IL4 TNF
2 regulation of signaling receptor activity GO:0010469 9.73 CXCL8 IL10 IL4 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.69 CXCL8 IL10 TNF
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.58 IL10 TNF
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 IL10 IL4
6 negative regulation of mitotic cell cycle GO:0045930 9.57 IL10 TNF
7 positive regulation of cytokine secretion GO:0050715 9.56 IL10 TNF
8 negative regulation of interleukin-6 production GO:0032715 9.55 IL10 TNF
9 embryonic digestive tract development GO:0048566 9.54 CXCL8 TNF
10 negative regulation of growth of symbiont in host GO:0044130 9.52 IL10 TNF
11 response to molecule of bacterial origin GO:0002237 9.49 CXCL8 IL10
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.46 IL10 TNF
13 cytokine-mediated signaling pathway GO:0019221 9.46 CXCL8 IL10 IL4 TNF
14 endothelial cell apoptotic process GO:0072577 9.4 IL10 TNF
15 positive regulation of MHC class II biosynthetic process GO:0045348 9.37 IL10 IL4
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.32 IL10 TNF
17 type 2 immune response GO:0042092 9.26 IL10 IL4
18 regulation of isotype switching GO:0045191 8.96 IL10 IL4
19 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Tungiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL10 IL4 TNF

Sources for Tungiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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