MCID: TNG001
MIFTS: 40

Tungiasis

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Tungiasis

MalaCards integrated aliases for Tungiasis:

Name: Tungiasis 12 77 54 60 45 15 17
Tunga Penetrans Infestation 74
Sarcopsylla Penetrans 54
Tunga Penetrans 54
Chigger Flea 54
S Penetrans 54
T Penetrans 54

Characteristics:

Orphanet epidemiological data:

60
tungiasis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050266
MeSH 45 D058285
ICD10 34 B88.1
MESH via Orphanet 46 D058285
ICD10 via Orphanet 35 B88.1
UMLS via Orphanet 75 C0277356
Orphanet 60 ORPHA879
UMLS 74 C0277356

Summaries for Tungiasis

Disease Ontology : 12 A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

MalaCards based summary : Tungiasis, also known as tunga penetrans infestation, is related to trichuriasis and scabies. An important gene associated with Tungiasis is MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. Affiliated tissues include skin.

Wikipedia : 77 Tungiasis (also known as nigua,pio and bicho de pie, or pique or sand flea disease) is an inflammatory... more...

Related Diseases for Tungiasis

Diseases related to Tungiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 207)
# Related Disease Score Top Affiliating Genes
1 trichuriasis 29.9 IL10 TNF
2 scabies 29.8 CXCL8 IL10
3 skin disease 29.3 CXCL8 IL10 IL4 TNF
4 malaria 29.0 CXCL8 IL10 IL4 TNF
5 dermatitis 10.4
6 cutaneous larva migrans 10.2
7 scleritis 10.2 IL4 TNF
8 allergic conjunctivitis 10.2 CXCL8 IL4
9 pleurisy 10.1 CXCL8 TNF
10 hemorrhagic fever with renal syndrome 10.1 CXCL8 TNF
11 bacterial vaginosis 10.1 CXCL8 TNF
12 acute respiratory distress syndrome 10.1 CXCL8 TNF
13 lichen disease 10.1 IL4 TNF
14 papillary conjunctivitis 10.1 CXCL8 IL4
15 giant papillary conjunctivitis 10.1 CXCL8 IL4
16 conjunctival disease 10.1 IL4 TNF
17 exudative glomerulonephritis 10.1 CXCL8 TNF
18 streptococcal toxic-shock syndrome 10.1 CXCL8 TNF
19 cardiac sarcoidosis 10.1 CXCL8 TNF
20 haemophilus influenzae 10.1 CXCL8 TNF
21 crohn's colitis 10.0 CXCL8 TNF
22 meconium aspiration syndrome 10.0 CXCL8 TNF
23 nasal cavity disease 10.0 IL10 IL4
24 mycobacterium abscessus 10.0 CXCL8 TNF
25 louse-borne relapsing fever 10.0 CXCL8 TNF
26 endometrial disease 10.0 CXCL8 TNF
27 dental pulp disease 10.0 CXCL8 TNF
28 periodontosis 10.0 CXCL8 TNF
29 pleural tuberculosis 10.0 CXCL8 TNF
30 tuberculous meningitis 10.0 CXCL8 TNF
31 melioidosis 10.0 IL10 TNF
32 primary progressive multiple sclerosis 10.0 IL10 TNF
33 echinococcosis 10.0 IL10 TNF
34 testicular disease 10.0 IL10 TNF
35 uveal disease 10.0 IL10 TNF
36 mixed connective tissue disease 10.0 IL10 TNF
37 reactive arthritis 10.0 IL10 TNF
38 lymph node disease 10.0 IL10 TNF
39 hyperlucent lung 10.0 IL10 IL4
40 glaucomatocyclitic crisis 10.0 CXCL8 TNF
41 rasmussen encephalitis 10.0 IL4 TNF
42 nickel allergic contact dermatitis 10.0 IL10 IL4
43 klippel-trenaunay-weber syndrome 10.0
44 myiasis 10.0
45 typhoid fever 10.0
46 plantar wart 10.0
47 yellow fever 10.0
48 retinitis pigmentosa 22 10.0 IL10 IL4
49 baylisascariasis 10.0 IL10 IL4
50 pulpitis 10.0 CXCL8 TNF

Graphical network of the top 20 diseases related to Tungiasis:



Diseases related to Tungiasis

Symptoms & Phenotypes for Tungiasis

Drugs & Therapeutics for Tungiasis

Search Clinical Trials , NIH Clinical Center for Tungiasis

Cochrane evidence based reviews: tungiasis

Genetic Tests for Tungiasis

Anatomical Context for Tungiasis

MalaCards organs/tissues related to Tungiasis:

42
Skin

Publications for Tungiasis

Articles related to Tungiasis:

(show top 50) (show all 164)
# Title Authors Year
1
Clinical and histopathologic study of 39 patients with imported tungiasis. ( 30632189 )
2019
2
Very severe tungiasis in Amerindians in the Amazon lowland of Colombia: A case series. ( 30730885 )
2019
3
Spatial distribution, prevalence and potential risk factors of Tungiasis in Vihiga County, Kenya. ( 30860992 )
2019
4
Dermoscopic Features of Tungiasis. ( 29430724 )
2018
5
Tungiasis Presenting as Onychomycosis: Probably the First Report of Flea Infestation of the Nail Observed Using Modified Potassium Hydroxide Mount Technique. ( 29736361 )
2018
6
Animal and human tungiasis-related knowledge and treatment practices among animal keeping households in Bugiri District, South-Eastern Uganda. ( 29017876 )
2018
7
Cutaneous larva migrans and tungiasis: infestations of the affluent society. ( 29417800 )
2018
8
Tungiasis-related life quality impairment in children living in rural Kenya. ( 29309411 )
2018
9
Tungiasis: A Rare Parasitic Infestation in Genitals of a Native Male from Kathmandu. ( 29353907 )
2018
10
Imported Tungiasis in a Non-endemic Country. ( 29984767 )
2018
11
Prevalence and risk factors of tungiasis among children of Wensho district, southern Ethiopia. ( 30200882 )
2018
12
A traveller's wart: tungiasis. ( 30295440 )
2018
13
Tungiasis in a Colombian patient. ( 28286017 )
2017
14
The prevalence and association with health-related quality of life of tungiasis and scabies in schoolchildren in southern Ethiopia. ( 28771469 )
2017
15
Treatment of tungiasis with a two-component dimeticone: a comparison between moistening the whole foot and directly targeting the embedded sand fleas. ( 28293130 )
2017
16
Disseminated tungiasis. ( 29166519 )
2017
17
Not a simple plantar wart: A case of tungiasis. ( 28924985 )
2017
18
Prevalence, intensity and risk factors of tungiasis in Kilifi County, Kenya: I. Results from a community-based study. ( 28991909 )
2017
19
Tungiasis: a poorly-known diagnosis in Europe. Two paradigmatic cases from Portugal. ( 29264904 )
2017
20
Tungiasis: Outbreak investigation of a zoonosis during overseas deployment. ( 29386713 )
2017
21
High-resolution infrared thermography: a new tool to assess tungiasis-associated inflammation of the skin. ( 28919835 )
2017
22
Secondary bacterial infections and antibiotic resistance among tungiasis patients in Western, Kenya. ( 28886013 )
2017
23
Canine tungiasis: High prevalence in a tourist region in Bahia state, Brazil. ( 28364835 )
2017
24
Control of Tungiasis in Absence of a Roadmap: Grassroots and Global Approaches. ( 30270889 )
2017
25
Tungiasis-associated morbidity in pigs and dogs in endemic villages of Uganda. ( 26817587 )
2016
26
Tungiasis: diagnosis at a glance. ( 26880125 )
2016
27
Tungiasis in Italy: An imported case of Tunga penetrans and review of the literature. ( 26876782 )
2016
28
Successful Treatment of Severe Tungiasis in Pigs Using a Topical Aerosol Containing Chlorfenvinphos, Dichlorphos and Gentian Violet. ( 27727268 )
2016
29
Two Severe Cases of Tungiasis in Goat Kids in Uganda. ( 27012871 )
2016
30
Disseminated tungiasis in a 78-year-old woman from Tanzania: a case report. ( 27998311 )
2016
31
Prevalence and clinical aspects of tungiasis in south-west Nigerian schoolchildren. ( 27402650 )
2016
32
Bullous tungiasis. ( 27068598 )
2016
33
Prevalence and risk factors associated with tungiasis in Mayuge district, Eastern Uganda. ( 27642416 )
2016
34
Animal Reservoirs of Zoonotic Tungiasis in Endemic Rural Villages of Uganda. ( 26473360 )
2015
35
Tungiasis: A Neglected Disease Related to Poverty. ( 26861421 )
2015
36
Tungiasis Outbreak in Travelers From Madagascar. ( 26031478 )
2015
37
Pathology and diagnosis of proliferative and ulcerative dermatitis associated with Tunga penetrans infestation in cattle. ( 25525141 )
2015
38
Epidemiology of tunga penetrans infestation in selected areas in Kiharu constituency, Murang'a County, Kenya. ( 28883944 )
2015
39
Dermoscopy in tungiasis. ( 25035378 )
2014
40
Tungiasis: "the greatest curse that has ever afflicted Africa". ( 25007105 )
2014
41
Tungiasis-a neglected disease with many challenges for global public health. ( 25356978 )
2014
42
Tungiasis in Haiti: a case series of 383 patients. ( 24601858 )
2014
43
Treatment of Tungiasis with dimeticone: a proof-of-principle study in rural Kenya. ( 25079375 )
2014
44
Tungiasis in Northern Tanzania: a clinical report from Qameyu village, Babati District, Manyara Region. ( 25390058 )
2014
45
Tungiasis presenting as a soft tissue oral lesion. ( 25186303 )
2014
46
Tungiasis under dermoscopy: in vivo and ex vivo examination of the cutaneous infestation due to Tunga penetrans. ( 24068146 )
2013
47
Histopathological features of tungiasis in Peru. ( 23478579 )
2013
48
Regression of severe tungiasis-associated morbidity after prevention of re-infestation: a case series from rural Madagascar. ( 24043689 )
2013
49
Prevention of tungiasis and tungiasis-associated morbidity using the plant-based repellent Zanzarin: a randomized, controlled field study in rural Madagascar. ( 24069481 )
2013
50
Tungiasis - A Janus-faced parasitic skin disease. ( 24211240 )
2013

Variations for Tungiasis

Expression for Tungiasis

Search GEO for disease gene expression data for Tungiasis.

Pathways for Tungiasis

Pathways related to Tungiasis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 CXCL8 IL10 IL4 TNF
2
Show member pathways
12.22 IL10 IL4 TNF
3
Show member pathways
12.12 CXCL8 IL4 TNF
4
Show member pathways
12.03 IL10 IL4 TNF
5
Show member pathways
12.01 CXCL8 IL10 IL4 TNF
6
Show member pathways
11.96 CXCL8 IL4 TNF
7 11.95 CXCL8 IL10 TNF
8 11.79 CXCL8 IL4 TNF
9 11.76 IL10 IL4 TNF
10 11.67 CXCL8 IL10 TNF
11 11.56 IL10 IL4 TNF
12
Show member pathways
11.51 CXCL8 IL4 TNF
13 11.49 CXCL8 IL10 TNF
14 11.43 IL10 IL4 TNF
15 11.34 CXCL8 IL4 TNF
16 11.31 CXCL8 IL10 IL4 TNF
17 11.3 IL10 IL4
18 11.2 IL10 TNF
19 11.19 CXCL8 IL10 TNF
20 11.17 IL10 TNF
21 11.12 IL4 TNF
22 11.01 IL10 IL4
23 10.97 CXCL8 TNF
24 10.83 CXCL8 TNF
25 10.79 CXCL8 IL10 IL4 TNF
26 10.79 IL10 IL4 TNF
27 10.78 CXCL8 IL10 IL4 TNF
28 10.61 CXCL8 IL10 IL4 TNF

GO Terms for Tungiasis

Biological processes related to Tungiasis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 CXCL8 IL10 IL4 TNF
2 regulation of signaling receptor activity GO:0010469 9.76 CXCL8 IL10 IL4 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.71 CXCL8 IL10 TNF
4 cytokine-mediated signaling pathway GO:0019221 9.62 CXCL8 IL10 IL4 TNF
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.59 IL10 IL4
6 negative regulation of mitotic cell cycle GO:0045930 9.58 IL10 TNF
7 negative regulation of interleukin-6 production GO:0032715 9.58 IL10 TNF
8 positive regulation of cytokine secretion GO:0050715 9.57 IL10 TNF
9 regulation of synapse organization GO:0050807 9.56 IL10 TNF
10 leukocyte chemotaxis GO:0030595 9.55 CXCL8 IL10
11 embryonic digestive tract development GO:0048566 9.51 CXCL8 TNF
12 negative regulation of growth of symbiont in host GO:0044130 9.49 IL10 TNF
13 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 IL10 TNF
14 response to molecule of bacterial origin GO:0002237 9.43 CXCL8 IL10
15 endothelial cell apoptotic process GO:0072577 9.4 IL10 TNF
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.37 IL10 IL4
17 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 IL10 TNF
18 regulation of isotype switching GO:0045191 9.16 IL10 IL4
19 type 2 immune response GO:0042092 8.96 IL10 IL4
20 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Tungiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL10 IL4 TNF

Sources for Tungiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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