MCID: TNG001
MIFTS: 42

Tungiasis

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Tungiasis

MalaCards integrated aliases for Tungiasis:

Name: Tungiasis 12 76 53 59 44 15
Tunga Penetrans Infestation 73
Sarcopsylla Penetrans 53
Tunga Penetrans 53
Chigger Flea 53
S Penetrans 53
T Penetrans 53

Characteristics:

Orphanet epidemiological data:

59
tungiasis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050266
MeSH 44 D058285
Orphanet 59 ORPHA879
UMLS via Orphanet 74 C0277356
MESH via Orphanet 45 D058285
ICD10 via Orphanet 34 B88.1
ICD10 33 B88.1
UMLS 73 C0277356

Summaries for Tungiasis

Disease Ontology : 12 A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

MalaCards based summary : Tungiasis, also known as tunga penetrans infestation, is related to scabies and trichuriasis. An important gene associated with Tungiasis is NDUFS3 (NADH:Ubiquinone Oxidoreductase Core Subunit S3), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. Affiliated tissues include skin, lung and bone.

Wikipedia : 76 Tungiasis (also known as nigua,pio and bicho de pie, or pique or sand flea disease) is an inflammatory... more...

Related Diseases for Tungiasis

Diseases related to Tungiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 scabies 29.9 CXCL8 IL10
2 trichuriasis 29.6 CXCL8 IL10 TNF
3 skin disease 29.6 CXCL8 IL10 IL4 TNF
4 malaria 29.3 CXCL8 IL10 IL4 TNF
5 dermatitis 10.4
6 cutaneous larva migrans 10.2
7 neuritis 10.1 IL4 TNF
8 autoimmune myocarditis 10.1 IL4 TNF
9 allergic conjunctivitis 10.1 CXCL8 IL4
10 scleritis 10.1 IL4 TNF
11 conjunctivitis 10.1 CXCL8 IL4
12 silicosis 10.1 CXCL8 TNF
13 chorioamnionitis 10.1 CXCL8 TNF
14 pleurisy 10.1 CXCL8 TNF
15 pneumoconiosis 10.1 CXCL8 TNF
16 hemorrhagic fever with renal syndrome 10.1 CXCL8 TNF
17 obstructive jaundice 10.1 CXCL8 TNF
18 duodenal ulcer 10.1 CXCL8 TNF
19 severe acute respiratory syndrome 10.1 CXCL8 TNF
20 bacterial vaginosis 10.1 CXCL8 TNF
21 avian influenza 10.1 CXCL8 TNF
22 atrophic gastritis 10.1 CXCL8 TNF
23 acute respiratory distress syndrome 10.1 CXCL8 TNF
24 lichen disease 10.1 IL4 TNF
25 papillary conjunctivitis 10.1 CXCL8 IL4
26 giant papillary conjunctivitis 10.1 CXCL8 IL4
27 conjunctival disease 10.1 IL4 TNF
28 exudative glomerulonephritis 10.1 CXCL8 TNF
29 streptococcal toxic-shock syndrome 10.1 CXCL8 TNF
30 cardiac sarcoidosis 10.0 CXCL8 TNF
31 ige responsiveness, atopic 10.0 IL10 IL4
32 immune deficiency disease 10.0 IL10 IL4
33 respiratory allergy 10.0 IL10 IL4
34 haemophilus influenzae 10.0 CXCL8 TNF
35 nasal cavity disease 10.0 IL10 IL4
36 food allergy 10.0 IL10 IL4
37 mitral valve disease 10.0 IL10 IL4
38 crohn's colitis 10.0 CXCL8 TNF
39 meconium aspiration syndrome 10.0 CXCL8 TNF
40 mycobacterium abscessus 10.0 CXCL8 TNF
41 louse-borne relapsing fever 10.0 CXCL8 TNF
42 endometrial disease 10.0 CXCL8 TNF
43 dental pulp disease 10.0 CXCL8 TNF
44 periodontosis 10.0 CXCL8 TNF
45 melioidosis 10.0 IL10 TNF
46 primary progressive multiple sclerosis 10.0 IL10 TNF
47 filariasis 10.0 IL10 TNF
48 lepromatous leprosy 10.0 IL10 TNF
49 hepatitis a 10.0 IL10 TNF
50 echinococcosis 10.0 IL10 TNF

Graphical network of the top 20 diseases related to Tungiasis:



Diseases related to Tungiasis

Symptoms & Phenotypes for Tungiasis

Drugs & Therapeutics for Tungiasis

Search Clinical Trials , NIH Clinical Center for Tungiasis

Cochrane evidence based reviews: tungiasis

Genetic Tests for Tungiasis

Anatomical Context for Tungiasis

MalaCards organs/tissues related to Tungiasis:

41
Skin, Lung, Bone, Heart, Lymph Node, Eye, Spinal Cord

Publications for Tungiasis

Articles related to Tungiasis:

(show top 50) (show all 161)
# Title Authors Year
1
Dermoscopic Features of Tungiasis. ( 29430724 )
2018
2
Tungiasis Presenting as Onychomycosis: Probably the First Report of Flea Infestation of the Nail Observed Using Modified Potassium Hydroxide Mount Technique. ( 29736361 )
2018
3
Animal and human tungiasis-related knowledge and treatment practices among animal keeping households in Bugiri District, South-Eastern Uganda. ( 29017876 )
2018
4
Cutaneous larva migrans and tungiasis: infestations of the affluent society. ( 29417800 )
2018
5
Tungiasis-related life quality impairment in children living in rural Kenya. ( 29309411 )
2018
6
Tungiasis: A Rare Parasitic Infestation in Genitals of a Native Male from Kathmandu. ( 29353907 )
2018
7
Imported Tungiasis in a Non-endemic Country. ( 29984767 )
2018
8
Prevalence and risk factors of tungiasis among children of Wensho district, southern Ethiopia. ( 30200882 )
2018
9
A traveller's wart: tungiasis. ( 30295440 )
2018
10
Tungiasis in a Colombian patient. ( 28286017 )
2017
11
The prevalence and association with health-related quality of life of tungiasis and scabies in schoolchildren in southern Ethiopia. ( 28771469 )
2017
12
Treatment of tungiasis with a two-component dimeticone: a comparison between moistening the whole foot and directly targeting the embedded sand fleas. ( 28293130 )
2017
13
Disseminated tungiasis. ( 29166519 )
2017
14
Not a simple plantar wart: A case of tungiasis. ( 28924985 )
2017
15
Prevalence, intensity and risk factors of tungiasis in Kilifi County, Kenya: I. Results from a community-based study. ( 28991909 )
2017
16
Tungiasis: a poorly-known diagnosis in Europe. Two paradigmatic cases from Portugal. ( 29264904 )
2017
17
Tungiasis: Outbreak investigation of a zoonosis during overseas deployment. ( 29386713 )
2017
18
High-resolution infrared thermography: a new tool to assess tungiasis-associated inflammation of the skin. ( 28919835 )
2017
19
Secondary bacterial infections and antibiotic resistance among tungiasis patients in Western, Kenya. ( 28886013 )
2017
20
Canine tungiasis: High prevalence in a tourist region in Bahia state, Brazil. ( 28364835 )
2017
21
Control of Tungiasis in Absence of a Roadmap: Grassroots and Global Approaches. ( 30270889 )
2017
22
Tungiasis-associated morbidity in pigs and dogs in endemic villages of Uganda. ( 26817587 )
2016
23
Tungiasis: diagnosis at a glance. ( 26880125 )
2016
24
Tungiasis in Italy: An imported case of Tunga penetrans and review of the literature. ( 26876782 )
2016
25
Successful Treatment of Severe Tungiasis in Pigs Using a Topical Aerosol Containing Chlorfenvinphos, Dichlorphos and Gentian Violet. ( 27727268 )
2016
26
Two Severe Cases of Tungiasis in Goat Kids in Uganda. ( 27012871 )
2016
27
Disseminated tungiasis in a 78-year-old woman from Tanzania: a case report. ( 27998311 )
2016
28
Prevalence and clinical aspects of tungiasis in south-west Nigerian schoolchildren. ( 27402650 )
2016
29
Bullous tungiasis. ( 27068598 )
2016
30
Prevalence and risk factors associated with tungiasis in Mayuge district, Eastern Uganda. ( 27642416 )
2016
31
Animal Reservoirs of Zoonotic Tungiasis in Endemic Rural Villages of Uganda. ( 26473360 )
2015
32
Tungiasis: A Neglected Disease Related to Poverty. ( 26861421 )
2015
33
Tungiasis Outbreak in Travelers From Madagascar. ( 26031478 )
2015
34
Pathology and diagnosis of proliferative and ulcerative dermatitis associated with Tunga penetrans infestation in cattle. ( 25525141 )
2015
35
Epidemiology of tunga penetrans infestation in selected areas in Kiharu constituency, Murang'a County, Kenya. ( 28883944 )
2015
36
Dermoscopy in tungiasis. ( 25035378 )
2014
37
Tungiasis: "the greatest curse that has ever afflicted Africa". ( 25007105 )
2014
38
Tungiasis-a neglected disease with many challenges for global public health. ( 25356978 )
2014
39
Tungiasis in Haiti: a case series of 383 patients. ( 24601858 )
2014
40
Treatment of Tungiasis with dimeticone: a proof-of-principle study in rural Kenya. ( 25079375 )
2014
41
Tungiasis in Northern Tanzania: a clinical report from Qameyu village, Babati District, Manyara Region. ( 25390058 )
2014
42
Tungiasis presenting as a soft tissue oral lesion. ( 25186303 )
2014
43
Tungiasis under dermoscopy: in vivo and ex vivo examination of the cutaneous infestation due to Tunga penetrans. ( 24068146 )
2013
44
Histopathological features of tungiasis in Peru. ( 23478579 )
2013
45
Regression of severe tungiasis-associated morbidity after prevention of re-infestation: a case series from rural Madagascar. ( 24043689 )
2013
46
Prevention of tungiasis and tungiasis-associated morbidity using the plant-based repellent Zanzarin: a randomized, controlled field study in rural Madagascar. ( 24069481 )
2013
47
Tungiasis - A Janus-faced parasitic skin disease. ( 24211240 )
2013
48
Two Cases of Imported Tungiasis with Severe Superinfection. ( 24352215 )
2013
49
A hemorrhagic-crusted papule with a central crater on the heel. Tungiasis. ( 23986152 )
2013
50
Tungiasis (sand flea disease): a parasitic disease with particular challenges for public health. ( 22941398 )
2013

Variations for Tungiasis

Expression for Tungiasis

Search GEO for disease gene expression data for Tungiasis.

Pathways for Tungiasis

Pathways related to Tungiasis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 CXCL8 IL10 IL4 TNF
2
Show member pathways
12.39 IL10 IL4 TNF
3
Show member pathways
12.36 IL10 IL4 TNF
4 12.33 IL10 IL4 TNF
5
Show member pathways
12.21 IL10 IL4 TNF
6
Show member pathways
12.11 CXCL8 IL4 TNF
7
Show member pathways
12.04 IL10 IL4 TNF
8
Show member pathways
12.01 CXCL8 IL10 IL4 TNF
9
Show member pathways
11.96 CXCL8 IL4 TNF
10 11.95 CXCL8 IL10 TNF
11
Show member pathways
11.84 CXCL8 IL10 IL4
12 11.79 CXCL8 IL4 TNF
13 11.76 IL10 IL4 TNF
14 11.67 CXCL8 IL10 TNF
15 11.56 IL10 IL4 TNF
16
Show member pathways
11.51 CXCL8 IL4 TNF
17 11.49 CXCL8 IL10 TNF
18 11.43 IL10 IL4 TNF
19 11.39 CXCL8 TNF
20 11.34 CXCL8 IL4 TNF
21 11.31 CXCL8 IL10 IL4 TNF
22 11.3 IL10 IL4
23 11.19 CXCL8 IL10 TNF
24 11.18 IL10 TNF
25 11.17 IL10 TNF
26 11.12 IL4 TNF
27 11.03 IL10 IL4
28 10.98 CXCL8 TNF
29 10.86 CXCL8 TNF
30 10.79 CXCL8 IL10 IL4 TNF
31 10.79 IL10 IL4 TNF
32 10.75 CXCL8 IL10 IL4 TNF
33 10.61 CXCL8 IL10 IL4 TNF

GO Terms for Tungiasis

Cellular components related to Tungiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CXCL8 DPT IL10 IL4 TNF

Biological processes related to Tungiasis according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.78 CXCL8 IL10 TNF
2 immune response GO:0006955 9.78 CXCL8 IL10 IL4 TNF
3 regulation of signaling receptor activity GO:0010469 9.73 CXCL8 IL10 IL4 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.7 CXCL8 IL10 TNF
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.6 IL10 TNF
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.59 IL10 IL4
7 negative regulation of mitotic cell cycle GO:0045930 9.58 IL10 TNF
8 negative regulation of interleukin-6 production GO:0032715 9.58 IL10 TNF
9 positive regulation of cytokine secretion GO:0050715 9.57 IL10 TNF
10 regulation of synapse organization GO:0050807 9.56 IL10 TNF
11 cytokine-mediated signaling pathway GO:0019221 9.56 CXCL8 IL10 IL4 TNF
12 leukocyte chemotaxis GO:0030595 9.55 CXCL8 IL10
13 embryonic digestive tract development GO:0048566 9.54 CXCL8 TNF
14 negative regulation of growth of symbiont in host GO:0044130 9.51 IL10 TNF
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 IL10 TNF
16 response to molecule of bacterial origin GO:0002237 9.46 CXCL8 IL10
17 endothelial cell apoptotic process GO:0072577 9.4 IL10 TNF
18 positive regulation of MHC class II biosynthetic process GO:0045348 9.37 IL10 IL4
19 negative regulation of cytokine secretion involved in immune response GO:0002740 9.32 IL10 TNF
20 regulation of isotype switching GO:0045191 9.16 IL10 IL4
21 type 2 immune response GO:0042092 8.96 IL10 IL4
22 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Tungiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL10 IL4 TNF

Sources for Tungiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....