MCID: TNG001
MIFTS: 38

Tungiasis

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Tungiasis

MalaCards integrated aliases for Tungiasis:

Name: Tungiasis 12 73 20 58 44 15 17
Tunga Penetrans Infestation 70
Sarcopsylla Penetrans 20
Tunga Penetrans 20
Chigger Flea 20
S Penetrans 20
T Penetrans 20

Characteristics:

Orphanet epidemiological data:

58
tungiasis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050266
MeSH 44 D058285
ICD10 32 B88.1
MESH via Orphanet 45 D058285
ICD10 via Orphanet 33 B88.1
UMLS via Orphanet 71 C0277356
Orphanet 58 ORPHA879
UMLS 70 C0277356

Summaries for Tungiasis

Disease Ontology : 12 A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

MalaCards based summary : Tungiasis, also known as tunga penetrans infestation, is related to parasitic ectoparasitic infectious disease and typhoid fever. An important gene associated with Tungiasis is SAT1 (Spermidine/Spermine N1-Acetyltransferase 1), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Affiliated tissues include skin.

Wikipedia : 73 Tungiasis is an inflammatory skin disease caused by infection with the female ectoparasitic Tunga... more...

Related Diseases for Tungiasis

Diseases related to Tungiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 565)
# Related Disease Score Top Affiliating Genes
1 parasitic ectoparasitic infectious disease 30.0 MT-CO2 IL4 CD4
2 typhoid fever 29.7 TNF IL1B IFNG
3 pyoderma 29.5 TNF IL1B CXCL8
4 scabies 29.5 IL10 CXCL8 CD4
5 filariasis 29.4 TNF IL10 IFNG
6 tetanus 29.4 TNF NSF IL4 IL1B IL10 IFNG
7 mansonelliasis 29.3 IL10 IFNG CXCL8
8 skin disease 29.2 TNF IL4 IL1B IL10 IFNG CXCL8
9 plague 29.1 TNF IL1B IL10 CD4
10 epidemic typhus 29.1 TNF PPP1R14A IL10 CD4 AFF2
11 leishmaniasis 28.9 TNF IL4 IL1B IL10 IFNG
12 viral hepatitis 28.9 TNF IL4 IL1B IL10 IFNG
13 disease by infectious agent 28.6 TNF IL4 IL1B IL10 IFNG CD4
14 neuritis 28.6 TNF MIF IL4 IL1B IL10 IFNG
15 leprosy 3 28.1 TNF IL4 IL1B IL10 IFNG CXCL8
16 dermatitis 28.1 TNF IL4 IL1B IL10 IFNG CXCL8
17 bacterial infectious disease 27.9 TNF MIF IL1B IL10 IFNG CXCL8
18 indian tick typhus 10.3 PPP1R14A AFF2
19 cytokine deficiency 10.3
20 japanese spotted fever 10.3 PPP1R14A AFF2
21 b-cell growth factor 10.3 IL4 IFNG
22 atopic keratoconjunctivitis 10.2 IL4 IFNG
23 autoimmune myocarditis 10.2 TNF IFNG
24 polyarticular juvenile idiopathic arthritis 10.2 TNF IFNG
25 necrotic uveal melanoma 10.2 IFNG CD4
26 skeletal tuberculosis 10.2 TNF IFNG
27 pediculus humanus corporis infestation 10.2 PPP1R14A AFF2
28 rheumatoid arthritis interstitial lung disease 10.2 TNF CD4
29 chronic beryllium disease 10.2 TNF IFNG
30 type 1 diabetes mellitus 23 10.2 TNF CD4
31 panophthalmitis 10.2 IFNG CD4
32 ocular tuberculosis 10.2 IFNG CD4
33 physiological polycythemia 10.2 TNF IL1B
34 meningovascular neurosyphilis 10.2 TNF CD4
35 bacillary angiomatosis 10.2 PPP1R14A CD4
36 myiasis 10.2
37 cutaneous larva migrans 10.2
38 penicilliosis 10.2 IFNG CD4
39 posttransplant acute limbic encephalitis 10.2
40 overgrowth syndrome 10.2
41 pemphigoid 10.2 TNF IL4 IFNG
42 suppurative lymphadenitis 10.2 IFNG CD4
43 vulvar vestibulitis syndrome 10.2 TNF IL1B
44 kashin-beck disease 10.1 TNF IL1B
45 scleritis 10.1 TNF IL4 IFNG
46 latex allergy 10.1 TNF IL4 IFNG
47 soft tissue sarcoma 10.1 TNF IFNG
48 microscopic colitis 10.1 TNF IL4 IFNG
49 blepharoconjunctivitis 10.1 IL4 CD4
50 keratosis 10.1

Graphical network of the top 20 diseases related to Tungiasis:



Diseases related to Tungiasis

Symptoms & Phenotypes for Tungiasis

Drugs & Therapeutics for Tungiasis

Search Clinical Trials , NIH Clinical Center for Tungiasis

Cochrane evidence based reviews: tungiasis

Genetic Tests for Tungiasis

Anatomical Context for Tungiasis

MalaCards organs/tissues related to Tungiasis:

40
Skin

Publications for Tungiasis

Articles related to Tungiasis:

(show top 50) (show all 300)
# Title Authors PMID Year
1
Clinical and macroscopic morphological features of canine tungiasis. 61
33474585 2021
2
Clinical and pathological aspects of first report of Tunga penetrans infestation on southern brown howler monkey (Alouatta guariba clamitans) in Rio Grande do Sul, Brazil. 61
32926759 2020
3
Assessing the potentials of two local topical ointments as affordable treatment against tungiasis infestation: A self-experimentation in Igbokoda, Nigeria. 61
32743082 2020
4
Epidemiology of tungiasis in sub-saharan Africa: a systematic review and meta-analysis. 61
32909926 2020
5
Tungiasis: Another Traveler's Concern. 61
32268143 2020
6
Mapping the Geographic Distribution of Tungiasis in Sub-Saharan Africa. 61
32722011 2020
7
Tungiasis in a returning traveller from the tropics. 61
31164240 2020
8
Spectrum of skin diseases in Amerindian villages of the Upper Oyapock, French Guiana. 61
32227343 2020
9
A traveller's wart: tungiasis. 61
30295440 2020
10
Efficacy and safety of dimeticones in the treatment of epidermal parasitic skin diseases with special emphasis on tungiasis: an evidence-based critical review. 61
32105621 2020
11
Ectoparasites: Pediculosis and tungiasis. 61
31306729 2020
12
Efficacy of a mixture of neem seed oil (Azadirachta indica) and coconut oil (Cocos nucifera) for topical treatment of tungiasis. A randomized controlled, proof-of-principle study. 61
31756189 2019
13
Cutaneous larva migrans and tungiasis: infestations of the affluent society. 61
29417800 2019
14
Prevalence and factors associated with intestinal parasitic infection among under-five children in and around Haro Dumal Town, Bale Zone, Ethiopia. 61
31656180 2019
15
Factors associated with tungiasis among primary school children: a cross-sectional study in a rural district in Rwanda. 61
31464600 2019
16
Tungiasis. 61
31411640 2019
17
Travelers' tropical skin diseases: Challenges and interventions. 61
30216601 2019
18
Tungiasis: a highly neglected disease among neglected diseases. Case series from Nduta refugee camp (Tanzania). 61
31281659 2019
19
Tungiasis, a rare case of plantar inflammatory disease, a review of travelers skin lesions for emergency providers. 61
30922527 2019
20
Seasonal variation and persistence of tungiasis infestation in dogs in an endemic community, Bahia State (Brazil): longitudinal study. 61
30976966 2019
21
Prevalence, intensity and risk factors of tungiasis in Kilifi County, Kenya II: Results from a school-based observational study. 61
31095558 2019
22
Tungiasis. 61
30943340 2019
23
Clinical and histopathologic study of 39 patients with imported tungiasis. 61
30632189 2019
24
Image Gallery: Tungiasis in four steps. 61
30933336 2019
25
Spatial distribution, prevalence and potential risk factors of Tungiasis in Vihiga County, Kenya. 61
30860992 2019
26
Very severe tungiasis in Amerindians in the Amazon lowland of Colombia: A case series. 61
30730885 2019
27
Tungiasis infestation of dermis fat graft in an anophthalmic socket. 61
30930673 2019
28
Imported Tungiasis in a Non-endemic Country. 61
29984767 2018
29
Prevalence and risk factors of tungiasis among children of Wensho district, southern Ethiopia. 61
30200882 2018
30
Dermoscopic features of tungiasis. 61
29430724 2018
31
Global output of research on epidermal parasitic skin diseases from 1967 to 2017. 61
30078380 2018
32
Not a simple plantar wart: a case of tungiasis. 61
28924985 2018
33
Tungiasis Presenting as Onychomycosis: Probably the First Report of Flea Infestation of the Nail Observed Using Modified Potassium Hydroxide Mount Technique. 61
29736361 2018
34
Tungiasis: A Rare Parasitic Infestation in Genitals of a Native Male from Kathmandu. 61
29353907 2018
35
Tungiasis-related life quality impairment in children living in rural Kenya. 61
29309411 2018
36
[Update of knowledge on Neglected Diseases in Haiti: Mansonelliasis, Tungiasis, Leprosy, and Anthrax]. 61
30763500 2018
37
Animal and human tungiasis-related knowledge and treatment practices among animal keeping households in Bugiri District, South-Eastern Uganda. 61
29017876 2018
38
Tungiasis: a poorly-known diagnosis in Europe. Two paradigmatic cases from Portugal. 61
29264904 2017
39
Tunga penetrans in Giant anteater (Myrmecophaga tridactyla) from Argentina. 61
31014605 2017
40
Tungiasis: Outbreak investigation of a zoonosis during overseas deployment. 61
29386713 2017
41
Prevalence, intensity and risk factors of tungiasis in Kilifi County, Kenya: I. Results from a community-based study. 61
28991909 2017
42
Secondary bacterial infections and antibiotic resistance among tungiasis patients in Western, Kenya. 61
28886013 2017
43
Disseminated tungiasis. 61
29166519 2017
44
The prevalence and association with health-related quality of life of tungiasis and scabies in schoolchildren in southern Ethiopia. 61
28771469 2017
45
Control of Tungiasis in Absence of a Roadmap: Grassroots and Global Approaches. 61
30270889 2017
46
Tungiasis in a Colombian patient. 61
28286017 2017
47
High intensity of Tunga penetrans infection causing severe disease among pigs in Busoga, South Eastern Uganda. 61
28662705 2017
48
Canine tungiasis: High prevalence in a tourist region in Bahia state, Brazil. 61
28364835 2017
49
Treatment of tungiasis with a two-component dimeticone: a comparison between moistening the whole foot and directly targeting the embedded sand fleas. 61
28293130 2017
50
High-resolution infrared thermography: a new tool to assess tungiasis-associated inflammation of the skin. 61
28919835 2017

Variations for Tungiasis

Expression for Tungiasis

Search GEO for disease gene expression data for Tungiasis.

Pathways for Tungiasis

Pathways related to Tungiasis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 TNF PPP1R14A MIF IL4 IL1B IL10
2
Show member pathways
13.35 TNF IL4 IL1B IL10 IFNG CXCL8
3
Show member pathways
12.82 TNF IL4 IL1B IL10 IFNG CXCL8
4
Show member pathways
12.64 TNF IL4 IL10 IFNG CD4
5
Show member pathways
12.61 CD4 IFNG IL10 IL1B IL4 TNF
6
Show member pathways
12.6 TNF IL1B IL10 IFNG CD4
7
Show member pathways
12.6 CD4 IFNG IL10 IL1B IL4 TNF
8 12.57 TNF IL4 IL1B IL10 IFNG
9
Show member pathways
12.36 TNF IL4 IL1B IFNG CXCL8
10
Show member pathways
12.34 TNF MIF IL1B IFNG CXCL8
11
Show member pathways
12.33 TNF IL4 IL1B IFNG
12
Show member pathways
12.28 TNF IL4 IL1B IL10 IFNG
13
Show member pathways
12.25 CXCL8 IFNG IL10 IL1B IL4 TNF
14 12.24 TNF IL1B IL10 IFNG
15
Show member pathways
12.19 CXCL8 IFNG IL1B IL4 TNF
16 12.18 TNF IL1B IL10 CXCL8
17 12.09 TNF IL1B IL10 CXCL8 CD4
18
Show member pathways
12 IL4 IL1B IFNG CD4
19 11.99 CD4 IFNG IL10 IL4 TNF
20 11.97 CXCL8 IL10 IL1B IL4 TNF
21 11.93 TNF IL4 IL1B CD4
22 11.9 TNF IL1B IFNG CXCL8
23
Show member pathways
11.89 IL4 IL1B IFNG CD4
24 11.88 CXCL8 IFNG IL10 IL1B TNF
25 11.8 TNF IL1B IL10 CXCL8
26 11.79 IL4 IFNG CXCL8
27
Show member pathways
11.79 TNF IL4 IFNG CXCL8
28
Show member pathways
11.71 CD4 IFNG IL10 IL1B TNF
29 11.71 TNF MIF IL4 IL1B IFNG CXCL8
30 11.7 CXCL8 IL1B IL4 TNF
31 11.69 TNF IL4 IL10
32 11.67 TNF IL1B IL10 IFNG CD4
33 11.62 TNF IL1B CXCL8
34
Show member pathways
11.57 CXCL8 IFNG IL1B MIF TNF
35 11.54 TNF IL1B IFNG
36 11.54 TNF IL1B IFNG
37 11.51 IL4 IL10 IFNG CD4
38 11.5 TNF IL1B IFNG
39 11.42 TNF IL1B IL10 IFNG CXCL8
40
Show member pathways
11.39 TNF IL10 IFNG
41 11.37 TNF IL1B IL10
42 11.36 IFNG IL10 IL1B TNF
43 11.34 TNF IL4 IL1B IL10 CXCL8
44 11.34 CD4 IFNG IL10 IL1B IL4 TNF
45 11.26 IFNG IL1B IL4 TNF
46 11.24 IL4 IL10 IFNG
47 11 TNF IL4 IL1B IL10 CXCL8
48 10.78 IL4 IL1B
49 10.56 CD4 IFNG IL10 IL1B IL4 TNF

GO Terms for Tungiasis

Cellular components related to Tungiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNF MIF IL4 IL1B IL10 IFNG

Biological processes related to Tungiasis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.05 TNF IL4 IL1B IFNG CXCL8
2 positive regulation of protein phosphorylation GO:0001934 9.92 TNF IL1B IFNG CD4
3 negative regulation of gene expression GO:0010629 9.89 TNF MIF IFNG CXCL8 AFF2
4 cellular response to lipopolysaccharide GO:0071222 9.87 TNF IL1B IL10 CXCL8
5 positive regulation of inflammatory response GO:0050729 9.86 TNF IL1B IFNG
6 positive regulation of interleukin-6 production GO:0032755 9.85 TNF IL1B IFNG
7 B cell differentiation GO:0030183 9.83 IL4 IL10 DNAJB9
8 regulation of insulin secretion GO:0050796 9.82 TNF IL1B IFNG
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.82 TNF IL4 IFNG
10 response to glucocorticoid GO:0051384 9.81 TNF IL10 BCHE
11 positive regulation of T cell proliferation GO:0042102 9.8 IL4 IL1B CD4
12 positive regulation of phagocytosis GO:0050766 9.73 TNF IL1B IFNG
13 interleukin-12-mediated signaling pathway GO:0035722 9.72 MIF IL10 IFNG
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 TNF IL1B IFNG
15 positive regulation of signaling receptor activity GO:2000273 9.68 IL10 IFNG
16 positive regulation of neuroinflammatory response GO:0150078 9.67 TNF IL1B
17 negative regulation of amyloid-beta clearance GO:1900222 9.67 TNF IFNG
18 response to molecule of bacterial origin GO:0002237 9.67 IL10 CXCL8
19 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
20 negative regulation of synaptic transmission GO:0050805 9.66 IL1B BCHE
21 microglial cell activation GO:0001774 9.65 TNF IL4 IFNG
22 endothelial cell apoptotic process GO:0072577 9.64 TNF IL10
23 cytokine-mediated signaling pathway GO:0019221 9.63 TNF IL4 IL1B IL10 CXCL8 CD4
24 vascular endothelial growth factor production GO:0010573 9.62 TNF IL1B
25 positive regulation of mononuclear cell migration GO:0071677 9.61 TNF IL4
26 negative regulation of cytokine production involved in immune response GO:0002719 9.61 TNF IL10
27 positive regulation of cellular respiration GO:1901857 9.6 IL4 IFNG
28 neuroinflammatory response GO:0150076 9.59 IL4 IFNG
29 type 2 immune response GO:0042092 9.58 IL4 IL10
30 positive regulation of fever generation GO:0031622 9.58 TNF IL1B
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 TNF IL1B IFNG
32 positive regulation of cytokine production GO:0001819 9.56 TNF MIF IL10 IFNG
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 TNF IL1B IL10
34 sequestering of triglyceride GO:0030730 9.52 TNF IL1B
35 regulation of isotype switching GO:0045191 9.51 IL4 IL10
36 positive regulation of MHC class II biosynthetic process GO:0045348 9.5 IL4 IL10 IFNG
37 immune response GO:0006955 9.5 TNF IL4 IL1B IL10 IFNG CXCL8
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 TNF IFNG
39 positive regulation of nitrogen compound metabolic process GO:0051173 9.43 TNF IFNG
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 TNF IL1B IFNG

Molecular functions related to Tungiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 TNF MIF IL4 IL1B IL10 IFNG

Sources for Tungiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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